TTTS
MCID: TWN001
MIFTS: 45

Twin-to-Twin Transfusion Syndrome (TTTS)

Categories: Blood diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Twin-to-Twin Transfusion Syndrome

MalaCards integrated aliases for Twin-to-Twin Transfusion Syndrome:

Name: Twin-to-Twin Transfusion Syndrome 40 12 73 20 15 17
Twin to Twin Transfusion Syndrome 20 58
Fetal Blood Loss from Fetal Hemorrhage into Co-Twin 12
Fetus-to-Fetus Placental Transfusion Syndrome 70
Feto-Fetal Transfusion Syndrome 58
Twin Twin Transfusion Syndrome 40
Fetofetal Transfusion Syndrome 20
Fetal Hemorrhage into Co-Twin 12
Twin-to-Twin Blood Transfer 12
Fetal Transfusion Syndrome 20
Twin to Twin Transfusion 12
Fetofetal Transfusion 44
Ttts 20

Classifications:

Orphanet: 58  
Rare haematological diseases
Rare immunological diseases


External Ids:

Disease Ontology 12 DOID:13576
MeSH 44 D005330
NCIt 50 C113824
SNOMED-CT 67 13404009
ICD10 32 O43.02
ICD10 via Orphanet 33 O43.0
Orphanet 58 ORPHA95431
UMLS 70 C2909036

Summaries for Twin-to-Twin Transfusion Syndrome

GARD : 20 Twin to twin transfusion syndrome (TTTS) is a rare condition that occurs during a twin pregnancy when blood moves from one twin (the "donor twin") to the other (the "recipient twin") while in the womb. TTTS is a complication that specifically occurs in identical (monozygotic) twin pregnancies that share the same "egg" sac (monochorionic) that may or may not share the same amniotic sac (monoamniotic). TTTS usually develops between 15 and 26 weeks of pregnancy. The donor twin may be born smaller, with paleness, anemia, and dehydration. The recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. Treatment may require repeated amniocentesis during pregnancy. Fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. After birth, treatment depends on the infant's specific symptoms. The donor twin may need a blood transfusion to treat anemia. The recipient twin may need to have the volume of body fluid reduced. This may involve an exchange transfusion. Medications may be given to treat heart failure in the recipient twin.

MalaCards based summary : Twin-to-Twin Transfusion Syndrome, also known as twin to twin transfusion syndrome, is related to oligohydramnios and anuria. An important gene associated with Twin-to-Twin Transfusion Syndrome is PGF (Placental Growth Factor), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Triamcinolone and Triamcinolone diacetate have been mentioned in the context of this disorder. Affiliated tissues include heart, placenta and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 Twin-to-twin transfusion syndrome (TTTS), also known as feto-fetal transfusion syndrome (FFTS), twin... more...

Related Diseases for Twin-to-Twin Transfusion Syndrome

Diseases related to Twin-to-Twin Transfusion Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 oligohydramnios 30.9 REN PGF PAPPA AGTR1
2 anuria 30.9 REN AGTR1
3 tricuspid valve insufficiency 30.6 REN PAPPA
4 proteinuria, chronic benign 30.6 REN FLT1 AGTR1
5 pulmonary edema 30.5 REN NPPA AGTR1
6 arteriovenous malformation 30.5 ENG ANGPT2 ANGPT1
7 placenta disease 30.3 REN PGF PAPPA FLT1
8 congestive heart failure 30.2 REN NPPA AGTR1
9 conn's syndrome 30.1 REN NPPA AGTR1
10 pulmonary hypertension 30.0 REN NPPA ENG ANGPT1 AGTR1
11 placental abruption 30.0 PGF PAPPA FLT1 ENG
12 exudative vitreoretinopathy 1 29.9 VEGFC PGF FLT1 ANGPT2 ANGPT1
13 placental insufficiency 29.9 PGF PAPPA FLT1 ANGPT2 ANGPT1
14 eclampsia 29.8 REN PGF PAPPA FLT1 ENG
15 placenta accreta 29.6 PGF PAPPA FLT1 ANGPT2 ANGPT1
16 pre-eclampsia 29.6 REN PGF PAPPA NPPA FLT1 ENG
17 heart disease 29.3 REN PGF PAPPA NPPA FLT1 ENG
18 polyhydramnios 10.8
19 polycythemia 10.7
20 cerebral palsy 10.7
21 preterm premature rupture of the membranes 10.5
22 hair whorl 10.5
23 enterocolitis 10.5
24 hydrops fetalis, nonimmune 10.5
25 lymphatic malformation 7 10.5
26 perinatal necrotizing enterocolitis 10.4
27 atrial standstill 1 10.4
28 deficiency anemia 10.4
29 periventricular leukomalacia 10.3
30 bronchopulmonary dysplasia 10.3
31 cancer-associated retinopathy 10.3 PGF FLT1
32 epithelioid hemangioendothelioma 10.3 PGF FLT1
33 glomeruloid hemangioma 10.3 FLT1 ENG
34 malignant ciliary body melanoma 10.3 VEGFD FLT1
35 ciliary body cancer 10.3 VEGFD FLT1
36 severe nonproliferative diabetic retinopathy 10.3 REN PGF
37 anal canal squamous cell carcinoma 10.3 VEGFD FLT1
38 milker's nodule 10.3 VEGFC PGF
39 hydrocephalus 10.3
40 blood group, globoside system 10.3 PGF FLT1
41 hypertensive retinopathy 10.3 REN AGTR1
42 acute mountain sickness 10.3 FLT1 AGTR1
43 fibromuscular dysplasia 10.3 REN AGTR1
44 congenital lymphedema 10.3 VEGFD VEGFC
45 angiokeratoma circumscriptum 10.3 FLT1 ANGPT1
46 primary lymphedema 10.3 VEGFD VEGFC
47 diaphragmatic hernia, congenital 10.2
48 down syndrome 10.2
49 constricting bands, congenital 10.2
50 jejunal atresia 10.2

Graphical network of the top 20 diseases related to Twin-to-Twin Transfusion Syndrome:



Diseases related to Twin-to-Twin Transfusion Syndrome

Symptoms & Phenotypes for Twin-to-Twin Transfusion Syndrome

MGI Mouse Phenotypes related to Twin-to-Twin Transfusion Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 AGTR1 ANGPT1 ANGPT2 ENG FLT1 NPPA
2 homeostasis/metabolism MP:0005376 9.36 AGTR1 ANGPT1 ANGPT2 ENG FLT1 NPPA

Drugs & Therapeutics for Twin-to-Twin Transfusion Syndrome

Drugs for Twin-to-Twin Transfusion Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
2 Triamcinolone diacetate Phase 4
3 Immunosuppressive Agents Phase 4
4 Triamcinolone hexacetonide Phase 4
5 triamcinolone acetonide Phase 4
6
Bevacizumab Approved, Investigational Phase 3 216974-75-3
7
Ranibizumab Approved Phase 3 347396-82-1 459903
8
Leuprolide Approved, Investigational Phase 3 53714-56-0 3911 657181
9
Ivermectin Approved, Investigational, Vet_approved Phase 2, Phase 3 70288-86-7 6474909
10 Angiogenesis Inhibitors Phase 3
11 Pharmaceutical Solutions Phase 3
12 Contraceptive Agents Phase 3
13 Ulipristal acetate Phase 3 126784-99-4
14 Antineoplastic Agents, Hormonal Phase 3
15 Antiparasitic Agents Phase 2, Phase 3
16
Lithium carbonate Approved Phase 2 554-13-2
17
Norepinephrine Approved Phase 2 51-41-2 439260
18
Ethanol Approved Phase 2 64-17-5 702
19
Cocaine Approved, Illicit Phase 2 50-36-2 5760 446220
20 Serotonin Uptake Inhibitors Phase 2
21
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202
22
Iron Approved Phase 1 7439-89-6 23925 29936
23
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
24
Imidazole Experimental, Investigational Phase 1 288-32-4 795
25 Immunologic Factors Phase 1
26 Adjuvants, Immunologic Phase 1
27 CPG-oligonucleotide Phase 1
28 Vaccines Phase 1
29 Interferon-gamma Phase 1
30 interferons Phase 1
31 Interleukin-12 Phase 1
32
Formaldehyde Approved, Vet_approved 50-00-0 712
33
Epinephrine Approved, Vet_approved 51-43-4 5816
34
Racepinephrine Approved 329-65-7 838
35
Lidocaine Approved, Vet_approved 137-58-6 3676
36
Methylprednisolone Approved, Vet_approved 83-43-2 6741
37
Methylprednisolone hemisuccinate Approved 2921-57-5
38
Prednisolone Approved, Vet_approved 50-24-8 5755
39
Prednisolone acetate Approved, Vet_approved 52-21-1
40
Prednisone Approved, Vet_approved 53-03-2 5865
41
Prednisolone phosphate Approved, Vet_approved 302-25-0
42
Metronidazole Approved 443-48-1 4173
43
Lamivudine Approved, Investigational 134678-17-4 60825
44
Rebamipide Approved, Investigational 90098-04-7
45
Curcumin Approved, Experimental, Investigational 458-37-7 969516
46
Turmeric Approved, Experimental, Investigational
47
Prednisolone hemisuccinate Experimental 2920-86-7
48 Anesthetics, Local
49 Epinephryl borate
50 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Transpupillary Thermotherapy (TTT) Alone Versus the Combined Therapy Consisting of TTT and Intravitreal Injection of Triamcinolone to Decrease Exudation in Choroidal Melanoma After Proton Beam Therapy Unknown status NCT02379000 Phase 4 Triamcinolone Acetonide
2 A Prospective, Randomized, Controlled Study on Intravitreal Ranibizumab (Lucentis) Combined With Transpupillary Thermotherapy (TTT) for Neovascular Age-related Macular Degeneration (AMD) Completed NCT00599222 Phase 3
3 A Phase III, Randomised, Parallel Group, Double-blind, Double-dummy, Active Comparator-controlled, Multicenter Study to Assess the Efficacy and Safety of PGL4001 vs GnRH-agonist for Pre-operative Ttt of Symptomatic Uterine Myomas Completed NCT00740831 Phase 3 PGL4001;leuprorelin
4 Use of Ivermectin as a Therapeutic Option for Patients With COVID-19 Recruiting NCT04445311 Phase 2, Phase 3 Ivermectin
5 tDCS as an add-on Treatment for Resistant Major Depression in Uni- or Bipolar Patients: a Randomized, Double-blind, Placebo Controlled Study Unknown status NCT01644747 Phase 2
6 Abstinence-Linked Money Management Completed NCT00536900 Phase 2
7 The Stability in Medication Responsiveness During Research Experiments in Parkinson's Disease Completed NCT04185740 Phase 2
8 Phase 1 Study of the Safety and Immunogenicity of Na-GST-1/Alhydrogel, With or Without a CpG ODN Adjuvant, in Healthy Adults Completed NCT02143518 Phase 1
9 A Prospective, Randomized Multicenter Trial of Amnioreduction Vs Selective Fetoscopic Laser Photocoagulation for the Treatment of Severe Twin-Twin Transfusion Syndrome Unknown status NCT00345852
10 Study Title: Emergency Cerclage in Twin Pregnancies at Imminent Risk of Preterm Birth: an Open-Label Randomised Controlled Trial Unknown status NCT03818867
11 An Educational Intervention, the First Step of the Train the Trainer (TTT) Plan, to Improve the Young Endoscopist's Ability to Find the Early Gastric Cancer:Prospective Study With Historical Control Unknown status NCT02385578
12 Assessment of Pulmonary Artery Pressure and Right Sided Hemodynamics in Patients With OSA Before and After CPAP TTT Unknown status NCT03276611
13 Localization of Indicators for Epithelial Mesenchymal Transformation in Gingiva From Chronic Periodontitis Patients as Compared to Healthy Individuals (Case Control Study) Unknown status NCT03462953
14 Fetoscopic Directed Laser Photocoagulation of Communicating Placental Vessels in Twin to Twin Transfusion Syndrome Completed NCT02506049
15 Are Renal Artery Doppler Indices Different Between Monochorionic Diamniotic Twins With Twin-twin Transfusion Syndrome and Monochorionic Diamniotic Twins Without Twin-twin Transfusion Syndrome? Completed NCT03449823
16 Selective Laser Photocoagulation of Communicating Vessels in Twin-Twin Transfusion Syndrome Completed NCT01622049
17 Does the Performance of the Ductus Venosus Doppler at 16 Weeks Allow to Increase the Screening of the Twin-twin Transfusion Syndrome and to Reduce the Neonatal Mortality? Completed NCT03579069
18 Translating Intensive Arm Rehabilitation in Stroke to a Telerehabilitation Format Completed NCT02665052
19 Neonatales Outcome Nach Intrauteriner Laserablation Mit 1.0mm-Optik Bei Fetofetalem Transfusionssyndrom Completed NCT03151915
20 Neurophysiological and Kinematic Predictors of Response in Chronic Stroke Completed NCT04283253
21 A Statewide Trial to Compare Three Training Models for Implementing an EBT Completed NCT02543359
22 Neurophysiological and Kinematic Predictors of Response in Chronic Stroke Completed NCT02658630
23 Short Term Low Dose Corticosteroids for Management of Post Covid-19 Pulmonary Fibrosis Completed NCT04551781 20 Mg Prednisone for 14 days;control
24 Feto-Fetal Transfusion Syndrome in Multiple Pregnancies Recruiting NCT04148859
25 USFetus Randomized Clinical Trial: Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome Recruiting NCT02122328
26 Evaluating Implementation Strategies to Scale-up Transdiagnostic Evidence-based Mental Health Care in Zambia Recruiting NCT03458039
27 The Canadian Underage Substance Use Prevention Trial Recruiting NCT04198974
28 Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise Recruiting NCT03775954
29 Austrian Registry on the Outcome of Monochorionic Multiple Pregnancies: A Multicenter Registry Study Recruiting NCT03171909
30 STT Study : Pediatric Follow-up of Children's From Monochorial-diamniotic Pregnancies Complicated With a Twin-to-twin Syndrome Active, not recruiting NCT02611856
31 The Utility of MRI Scoring to Predict Neurodevelopmental Outcomes in Survivors Active, not recruiting NCT02249624
32 Determination of the "Tissue Transit Time" (TTT) in the MAG3-Tc99 Diuretic Renogram for Risk Stratification of Infants With Ureteropelvic Junction Obstruction - a Multicentric Prospective Observational Study Active, not recruiting NCT03311256
33 A Randomized Clinical Trial Comparing a Tunable-tension Transobturator Tape (TTT) Versus Standard Transobturator Midurethral Tape (TOT) for the Surgical Treatment of Stress Urinary Incontinence in Women Not yet recruiting NCT03958695
34 Effect of Treatment With REbamipide for Helicobacter Pylori Eradication Therapy Not yet recruiting NCT04550858 Rebamipide
35 The Effect of Premedication With Curcumin on Post-Operative Pain in Single Visit Endodontic Treatment of Acute Pulpitis in Mandibular Molars: A Randomized Controlled Trial Not yet recruiting NCT04012424 curcumin group:Curcumin is an ancient coloring spice . Interestingly, it has various pharmacological activities including analgesic, anti-inf
36 Automated Myocardial Performance Index Before, During and After Fetal Surgeries Using Samsung HERA W10 Terminated NCT04140669
37 Arabin Cervical Pessary for Prevention of Preterm Birth in Cases of Twin-to-twin Transfusion Syndrome Treated by Fetoscopic Laser Coagulation: The PECEP Laser Trial Terminated NCT01334489

Search NIH Clinical Center for Twin-to-Twin Transfusion Syndrome

Cochrane evidence based reviews: fetofetal transfusion

Genetic Tests for Twin-to-Twin Transfusion Syndrome

Anatomical Context for Twin-to-Twin Transfusion Syndrome

MalaCards organs/tissues related to Twin-to-Twin Transfusion Syndrome:

40
Heart, Placenta, Kidney, Brain, Fetal Brain, Eye, Bone

Publications for Twin-to-Twin Transfusion Syndrome

Articles related to Twin-to-Twin Transfusion Syndrome:

(show top 50) (show all 776)
# Title Authors PMID Year
1
Perinatal outcome after planned vaginal delivery in monochorionic compared with dichorionic twin pregnancy. 61
33078466 2021
2
Perioperative Care of Patients Diagnosed With Twin-to-Twin Transfusion Syndrome Undergoing Laparoscopic-Assisted Fetoscopic Placental Laser Photocoagulation. 61
33788229 2021
3
A novel "video-game" simulator for training fetoscopic laser coagulation of anastomoses in twin-to-twin transfusion syndrome. 61
33694186 2021
4
Twin-to-Twin Transfusion Syndrome: Diagnostic Imaging and Its Role in Staving Off Malpractice Charges and Litigation. 61
33806678 2021
5
Twin-To-Twin Transfusion Syndrome Donor and Recipient and Their Subsequent Cognitive Functioning in Late Childhood as Juvenile Athletes-A Case Study. 61
33806653 2021
6
Perinatal outcome of twin-to-twin transfusion syndrome complicated with incidental septostomy after laser surgery: a systematic review and meta-analysis. 61
33780009 2021
7
Radiofrequency ablation for selective fetal reduction in complicated Monochorionic twins; comparing the outcomes according to the indications. 61
33676436 2021
8
Antenatal management and neonatal outcomes of monochorionic twin pregnancies in a tertiary teaching hospital: a 10-year review. 61
33682597 2021
9
Fetal surgery. 61
33720314 2021
10
Hypertensive disorders of pregnancy in twin gestations complicated by gestational diabetes. 61
31096815 2021
11
A shape-constraint adversarial framework with instance-normalized spatio-temporal features for inter-fetal membrane segmentation. 61
33647785 2021
12
Clinical Significance of Velamentous Cord Insertion Prenatally Diagnosed in Twin Pregnancy. 61
33546368 2021
13
Longer distance between umbilical cord insertions is associated with spontaneous twin anemia polycythemia sequence. 61
32897576 2021
14
[Acute twin to twin transfusion syndrome: case report]. 61
33631885 2021
15
Novel Technique for the Measurement of Fetal Right Modified Myocardial Performance Index Using Synchronized Images of Right Ventricular Inflow and Outflow and Clinical Application to Twin-to-Twin Transfusion Syndrome. 61
33496009 2021
16
Evaluation of cardiac function in the recipient twin in successfully treated twin-to-twin transfusion syndrome using a novel fetal speckle-tracking analysis. 61
33015877 2021
17
Modified fetoscopic laser surgery in twin-to-twin transfusion syndrome with proximate cord insertions: a report of two cases and literature review. 61
30651014 2021
18
Study of the placental characteristics and time of onset of twin-to-twin transfusion syndrome. 61
33068961 2021
19
Monozygotic twins discordant for homologous Robertsonian translocation trisomy 21 of 46, XX, + 21, der (21;21) (q10; q10) in a twin-to-twin transfusion syndrome, case report. 61
33516175 2021
20
Perinatal outcomes of iatrogenic chorioamniotic separation following fetoscopic surgeries: a systematic review and meta-analysis. 61
33428299 2021
21
Feasibility of Umbilical Cord Blood Collection in Neonates at Risk of Brain Damage-A Step Toward Autologous Cell Therapy for a High-risk Population. 61
33631961 2021
22
Inter-twin differences in fetal echocardiographic findings are associated with decreased dual twin survival in twin-twin transfusion syndrome. 61
33455509 2021
23
Twin-twin transfusion syndrome - a University Hospital experience with intrauterine treatment. 61
33503142 2021
24
Perinatal outcomes of twin pregnancies complicated by late twin-twin transfusion syndrome: A systematic review and meta-analysis. 61
33337543 2020
25
Fortnightly surveillance of monochorionic diamniotic twins for twin to twin transfusion syndrome: Compliance and effectiveness. 61
32779751 2020
26
Remembering John C. Loehlin: 'Our Field Has Lost a Lion'/Twin Research Reviews: Cognitive Skills and Social Mobility, Risk of Arachnoid Hemorrhage, Heritability of Dental Traits, and Twin-to-Twin Transfusion Syndrome/Media Reports: Identical Twins With Different Health Histories, Twins Born 97 Days Apart, Retiring Twin Tennis Players, TikTok Twins and Twin Reality Stars. 61
33267937 2020
27
Intrauterine fetoscopic laser surgery versus expectant management in stage 1 twin-to-twin transfusion syndrome: an international randomized trial. 61
33248135 2020
28
The prevalence of brain lesions after in utero surgery for twin-to-twin transfusion syndrome on third-trimester MRI: a retrospective cohort study. 61
33210202 2020
29
TTTS-STgan: Stacked Generative Adversarial Networks for TTTS Fetal Surgery Planning Based on 3D Ultrasound. 61
32746107 2020
30
Deep learning-based fetoscopic mosaicking for field-of-view expansion. 61
32808148 2020
31
Segmentation of the placenta and its vascular tree in Doppler ultrasound for fetal surgery planning. 61
32951100 2020
32
Comparison of placental characteristics of twin-twin transfusion syndrome with and without selective intrauterine growth restriction. 61
33203261 2020
33
Cause of intrauterine and neonatal death in twin pregnancies (CoDiT): development of a novel classification system. 61
32359214 2020
34
Prediction of fetal death in selective growth restriction complicating twin-twin transfusion syndrome using standardized definitions. 61
33073885 2020
35
Abdominal circumference discordance for prediction of small for gestational age at birth in twin pregnancies. 61
33043775 2020
36
The Use of Sequential Integrated Screening to Stratify Risk in Monochorionic-Diamniotic Twin Pregnancies. 61
33032330 2020
37
Deep Q-CapsNet Reinforcement Learning Framework for Intrauterine Cavity Segmentation in TTTS Fetal Surgery Planning. 61
32305906 2020
38
Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders. 61
33096092 2020
39
Management of monochorionic twins discordant for structural fetal anomalies. 61
32394424 2020
40
Prediction of Twin-to-Twin Transfusion Syndrome Using Characteristic Waveforms of Ductus Venosus in Recipient Twins. 61
33004103 2020
41
Screening, Management and Delivery in Twin Pregnancy. 61
33017845 2020
42
Outcomes following selective fetoscopic laser ablation for twin-to-twin transfusion syndrome: a single-centre experience. 61
31489429 2020
43
Cerebral Oxygenation in Preterm Infants With Necrotizing Enterocolitis. 61
32848028 2020
44
Comparison of crown-rump length discordance and abnormal cord insertions as first-trimester predictors of poor outcome in monochorionic diamniotic twin pregnancies. 61
32933362 2020
45
Incidence and survival outcomes of monochorionic diamniotic twin pregnancies with twin-to-twin transfusion syndrome presenting without amniotic fluid discordance due to spontaneous septostomy and treated with fetoscopy. 61
32959414 2020
46
Double Trouble: Complications in Twin Pregnancies. 61
32890327 2020
47
Deep learning-based monocular placental pose estimation: towards collaborative robotics in fetoscopy. 61
32350788 2020
48
Mentoring a surgical team towards procedural competence in the early learning curve for selective fetoscopic laser photocoagulation. 61
33047141 2020
49
Perinatal outcomes of twin pregnancies affected by early twin-twin transfusion syndrome: A systematic review and meta-analysis. 61
32162305 2020
50
Prenatal and perinatal outcomes of twin pregnancy discordant for one fetus with nuchal translucency above the 95th percentile. 61
32907415 2020

Variations for Twin-to-Twin Transfusion Syndrome

Expression for Twin-to-Twin Transfusion Syndrome

Search GEO for disease gene expression data for Twin-to-Twin Transfusion Syndrome.

Pathways for Twin-to-Twin Transfusion Syndrome

Pathways related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 VEGFD VEGFC PGF FLT1 ANGPT2 ANGPT1
2
Show member pathways
13.2 VEGFD VEGFC PGF FLT1 ANGPT2 ANGPT1
3
Show member pathways
13.1 VEGFD VEGFC PGF FLT1 ANGPT2 ANGPT1
4
Show member pathways
12.82 VEGFD VEGFC REN PGF FLT1 AGTR1
5
Show member pathways
12.75 VEGFD VEGFC PGF FLT1 ANGPT2 ANGPT1
6
Show member pathways
12.51 VEGFD VEGFC PGF FLT1
7 12.4 VEGFD VEGFC PGF FLT1 ANGPT2 ANGPT1
8
Show member pathways
12.28 VEGFD VEGFC PGF FLT1 ANGPT2 ANGPT1
9
Show member pathways
12.21 VEGFD VEGFC PGF FLT1
10
Show member pathways
12.2 VEGFD VEGFC PGF FLT1
11 12.18 VEGFD VEGFC FLT1 AGTR1
12
Show member pathways
12.08 VEGFD VEGFC PGF FLT1
13
Show member pathways
12.04 PSG2 ANGPT2 ANGPT1
14 11.94 VEGFC FLT1 ANGPT2
15 11.71 VEGFD VEGFC AGTR1
16 11.71 NPPA FLT1 ANGPT2 ANGPT1
17
Show member pathways
11.65 VEGFC PGF FLT1
18 11.49 REN NPPA AGTR1
19 11.3 VEGFC REN FLT1 ENG ANGPT2
20 10.99 FLT1 ANGPT1
21 10.98 ENG ANGPT2 AGTR1
22 10.96 VEGFD VEGFC
23 10.7 VEGFD VEGFC PGF FLT1 ANGPT2 ANGPT1
24
Show member pathways
10.13 VEGFD VEGFC PGF FLT1

GO Terms for Twin-to-Twin Transfusion Syndrome

Cellular components related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 VEGFD VEGFC REN PSG2 PGF PAPPA
2 extracellular space GO:0005615 9.32 VEGFD VEGFC REN PGF PAPPA NPPA

Biological processes related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.05 VEGFD VEGFC PGF FLT1 ANGPT2 ANGPT1
2 cell differentiation GO:0030154 10.03 VEGFD VEGFC PGF FLT1 ANGPT2 ANGPT1
3 positive regulation of protein phosphorylation GO:0001934 9.85 VEGFD VEGFC PGF ENG ANGPT1
4 response to hypoxia GO:0001666 9.8 VEGFD VEGFC PGF NPPA ENG ANGPT2
5 female pregnancy GO:0007565 9.74 PSG2 PAPPA NPPA
6 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.73 VEGFD VEGFC PGF FLT1
7 positive regulation of endothelial cell proliferation GO:0001938 9.72 VEGFD VEGFC PGF
8 positive regulation of cell division GO:0051781 9.71 VEGFD VEGFC PGF
9 positive chemotaxis GO:0050918 9.71 VEGFD VEGFC PGF ANGPT1
10 induction of positive chemotaxis GO:0050930 9.65 VEGFD VEGFC PGF
11 positive regulation of angiogenesis GO:0045766 9.63 VEGFD VEGFC PGF FLT1 ENG ANGPT2
12 blood vessel morphogenesis GO:0048514 9.58 FLT1 ANGPT2
13 vascular endothelial growth factor signaling pathway GO:0038084 9.56 VEGFD VEGFC PGF FLT1
14 positive regulation of mast cell chemotaxis GO:0060754 9.54 VEGFD VEGFC PGF
15 glomerulus vasculature development GO:0072012 9.52 ANGPT2 ANGPT1
16 Tie signaling pathway GO:0048014 9.51 ANGPT2 ANGPT1
17 angiogenesis GO:0001525 9.5 VEGFD VEGFC PGF FLT1 ENG ANGPT2
18 renin-angiotensin regulation of aldosterone production GO:0002018 9.49 REN AGTR1
19 sprouting angiogenesis GO:0002040 9.02 VEGFD VEGFC PGF ENG ANGPT1

Molecular functions related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.56 REN NPPA ANGPT2 ANGPT1
2 growth factor activity GO:0008083 9.5 VEGFD VEGFC PGF
3 chemoattractant activity GO:0042056 9.33 VEGFD VEGFC PGF
4 vascular endothelial growth factor receptor 3 binding GO:0043185 8.96 VEGFD VEGFC
5 vascular endothelial growth factor receptor binding GO:0005172 8.8 VEGFD VEGFC PGF

Sources for Twin-to-Twin Transfusion Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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