Aliases & Classifications for Twinning, Dizygotic

MalaCards integrated aliases for Twinning, Dizygotic:

Name: Twinning, Dizygotic 58 56 41
Ovarian Response to Fsh Stimulation 58 13 6

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive vs. multifactorial


Classifications:



External Ids:

OMIM 58 276400
MedGen 43 C0220761

Summaries for Twinning, Dizygotic

MalaCards based summary : Twinning, Dizygotic, also known as ovarian response to fsh stimulation, is related to premature ovarian failure 1 and infertility. An important gene associated with Twinning, Dizygotic is FSHR (Follicle Stimulating Hormone Receptor), and among its related pathways/superpathways is Ovarian Infertility Genes. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include t cells and brain, and related phenotype is neoplasm.

Description from OMIM: 276400

Related Diseases for Twinning, Dizygotic

Diseases related to Twinning, Dizygotic via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 premature ovarian failure 1 9.7 FSHR INHA
2 infertility 9.6 FSHR INHA
3 ovarian cancer 9.5 FSHR INHA

Symptoms & Phenotypes for Twinning, Dizygotic

Symptoms via clinical synopsis from OMIM:

58
Misc:
dizygotic twinning
female line transmission

Clinical features from OMIM:

276400

MGI Mouse Phenotypes related to Twinning, Dizygotic:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.62 FSHR INHA

Drugs & Therapeutics for Twinning, Dizygotic

Drugs for Twinning, Dizygotic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Immunologic Factors Phase 4
3
Metformin Approved Phase 1,Not Applicable 657-24-9 14219 4091
4 Hypoglycemic Agents Phase 1,Not Applicable
5 interferons

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) - Year 1, 2009 Completed NCT01987349 Phase 4
2 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 2, 2010 Completed NCT03022396 Phase 4
3 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 5, 2013 Completed NCT03023176 Phase 4
4 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 4, 2012 Completed NCT03022435 Phase 4
5 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 3, 2011 Completed NCT03022422 Phase 4
6 Genetic and Environmental Factors in the Response to Influenza Vaccination Completed NCT03088904 Phase 4
7 Study of Metformin Pharmacogenetics in Twins Completed NCT01869621 Phase 1 Metformin
8 Impact of Genetics on Metformin Pharmacokinetics Completed NCT00187798 Not Applicable Metformin HCl
9 Heritability of Sleep Homeostasis in Twins Completed NCT02827461
10 Depression, Genes, Cytokines, Chronic Fatigue, Physical Illnesses and Quality of Life Completed NCT02943330
11 Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder Completed NCT00161161
12 Twins Born in Guangzhou Recruiting NCT03331133
13 Food Effects on the Gut Microbiota Active, not recruiting NCT03078283 Not Applicable
14 Characterization of the Facial and Gut Microbiome in Rosacea Not yet recruiting NCT03228927

Search NIH Clinical Center for Twinning, Dizygotic

Genetic Tests for Twinning, Dizygotic

Anatomical Context for Twinning, Dizygotic

MalaCards organs/tissues related to Twinning, Dizygotic:

42
T Cells, Brain

Publications for Twinning, Dizygotic

Articles related to Twinning, Dizygotic:

# Title Authors Year
1
Follicle-stimulating-hormone receptor and twinning. ( 11213123 )
2001
2
Association between mutations of the follicle-stimulating-hormone receptor and repeated twinning. ( 11036902 )
2000
3
Mutational analysis of the follicle-stimulating hormone (FSH) receptor in normal and infertile men: identification and characterization of two discrete FSH receptor isoforms. ( 10022448 )
1999

Variations for Twinning, Dizygotic

ClinVar genetic disease variations for Twinning, Dizygotic:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FSHR NM_000145.3(FSHR): c.919G> A (p.Ala307Thr) single nucleotide variant Benign rs6165 GRCh37 Chromosome 2, 49191041: 49191041
2 FSHR NM_000145.3(FSHR): c.919G> A (p.Ala307Thr) single nucleotide variant Benign rs6165 GRCh38 Chromosome 2, 48963902: 48963902

Expression for Twinning, Dizygotic

Search GEO for disease gene expression data for Twinning, Dizygotic.

Pathways for Twinning, Dizygotic

Pathways related to Twinning, Dizygotic according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 FSHR INHA

GO Terms for Twinning, Dizygotic

Biological processes related to Twinning, Dizygotic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 8.96 FSHR INHA
2 regulation of MAPK cascade GO:0043408 8.62 FSHR INHA

Sources for Twinning, Dizygotic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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