Aliases & Classifications for Twinning, Dizygotic

MalaCards integrated aliases for Twinning, Dizygotic:

Name: Twinning, Dizygotic 57 54 6 39
Ovarian Response to Fsh Stimulation 57 29 13 6

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal recessive vs. multifactorial


Classifications:



External Ids:

OMIM® 57 276400
MedGen 41 C0220761

Summaries for Twinning, Dizygotic

MalaCards based summary : Twinning, Dizygotic, also known as ovarian response to fsh stimulation, is related to sex cord-gonadal stromal tumor and precocious puberty, male-limited. An important gene associated with Twinning, Dizygotic is FSHR (Follicle Stimulating Hormone Receptor), and among its related pathways/superpathways is Ovarian Infertility Genes. Affiliated tissues include pituitary and breast, and related phenotype is neoplasm.

More information from OMIM: 276400

Related Diseases for Twinning, Dizygotic

Diseases related to Twinning, Dizygotic via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 sex cord-gonadal stromal tumor 9.7 INHA FSHR
2 precocious puberty, male-limited 9.7 INHA FSHR
3 premature menopause 9.6 INHA FSHR
4 male infertility 9.6 INHA FSHR
5 infertility 9.5 INHA FSHR

Graphical network of the top 20 diseases related to Twinning, Dizygotic:



Diseases related to Twinning, Dizygotic

Symptoms & Phenotypes for Twinning, Dizygotic

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Misc:
dizygotic twinning
female line transmission

Clinical features from OMIM®:

276400 (Updated 05-Apr-2021)

MGI Mouse Phenotypes related to Twinning, Dizygotic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.62 FSHR INHA

Drugs & Therapeutics for Twinning, Dizygotic

Search Clinical Trials , NIH Clinical Center for Twinning, Dizygotic

Genetic Tests for Twinning, Dizygotic

Genetic tests related to Twinning, Dizygotic:

# Genetic test Affiliating Genes
1 Ovarian Response to Fsh Stimulation 29

Anatomical Context for Twinning, Dizygotic

MalaCards organs/tissues related to Twinning, Dizygotic:

40
Pituitary, Breast

Publications for Twinning, Dizygotic

Articles related to Twinning, Dizygotic:

(show all 44)
# Title Authors PMID Year
1
Dizygotic twinning is not linked to variation at the alpha-inhibin locus on human chromosome 2. 57 54
10999839 2000
2
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility. 57
27132594 2016
3
Familial twinning and fertility in Dutch mothers of twins. 57
19012341 2008
4
Genome-wide linkage scan for spontaneous DZ twinning. 57
16288310 2006
5
IBD sharing around the PPARG locus is not increased in dizygotic twins or their mothers. 57
11479591 2001
6
Childhood cancer incidence in a cohort of twin babies. 57
11384093 2001
7
An epidemiological study of cancer in adult twins born in Norway 1905-1945. 57
11384094 2001
8
Human twinning is not linked to the region of chromosome 4 syntenic with the sheep twinning gene FecB. 57
11343301 2001
9
Follicle-stimulating-hormone receptor and twinning. 6
11213123 2001
10
A region on chromosome 3 is linked to dizygotic twinning. 57
11101833 2000
11
Association between mutations of the follicle-stimulating-hormone receptor and repeated twinning. 6
11036902 2000
12
Mutational analysis of the follicle-stimulating hormone (FSH) receptor in normal and infertile men: identification and characterization of two discrete FSH receptor isoforms. 6
10022448 1999
13
Natural selection on human twinning. 57
9707112 1998
14
Genetic contribution to DZ twinning. 57
8741868 1996
15
Genetic modelling of dizygotic twinning in pedigrees of spontaneous dizygotic twins. 57
8741871 1996
16
Immunological manipulation of ovulation rate for twinning in cattle. 57
7623326 1995
17
The ovine Booroola fecundity gene (FecB) is linked to markers from a region of human chromosome 4q. 57
8401591 1993
18
Pituitary-ovarian function in mothers who have had two sets of dizygotic twins. 57
6427021 1984
19
Familial incidence of twinning. 57
6683788 1983
20
Distribution among relatives of genotypes for twinning. 57
5689275 1968
21
PITUITARY GONADOTROPHIN AND DIZYGOTIC TWINNING. 57
14172355 1964
22
The Relationship Between Serum Delta FSH Level and Ovarian Response in IVF/ICSI Cycles. 61
33224104 2020
23
Postnatal pituitary and follicular activation: a revisited hypothesis in a sheep model. 61
26621920 2016
24
Intraovarian control of early folliculogenesis. 61
25202833 2015
25
Anti-Müllerian hormone concentration in sheep and its dependence of age and independence of BMP15 genotype: an endocrine predictor to select the best donors for embryo biotechnologies. 61
24268018 2014
26
Association of allelic combinations of FSHR gene polymorphisms with ovarian response. 61
23953588 2013
27
Aromatase (CYP19) gene variants influence ovarian response to standard gonadotrophin stimulation. 61
22089263 2012
28
Follicle-stimulating hormone receptor polymorphism (G-29A) is associated with altered level of receptor expression in Granulosa cells. 61
21752882 2011
29
A prospective, randomized, double-blinded study of assisted hatching in women younger than 38 years undergoing in vitro fertilization. 61
19268926 2010
30
Single-nucleotide polymorphisms in the FSH receptor gene and ovarian performance: future role in IVF. 61
20184506 2010
31
Infertility, bilateral multicystic serous cystadenoma and pregnancy. 61
18682003 2008
32
Pharmacogenetics in ovarian stimulation--current concepts. 61
18443324 2008
33
Anti-FSH antibodies associate with poor outcome of ovarian stimulation in IVF. 61
18339255 2008
34
Polymorphism of the FSH receptor and ovarian response to FSH. 61
17544358 2007
35
Clinical and biological parameters influencing implantation: score to determine number of embryos to transfer. 61
16740218 2006
36
Pharmacogenetics in ovarian stimulation - current concepts and future options. 61
16409708 2005
37
Association of inhibin B serum levels with parameters of follicular response in a randomized controlled trial comparing gnRH agonist versus antagonist protocols for ovarian hyperstimulation. 61
15526982 2004
38
Human cumulus-free oocyte maturational profile and in vitro developmental potential after stimulation with recombinant versus urinary FSH. 61
14747172 2004
39
Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction. 61
12398222 2002
40
Mutations in the follicle-stimulating hormone receptor and familial dizygotic twinning. 54
11253976 2001
41
Is there a role for follicle-stimulating-hormone receptor in familial dizygotic twinning? 54
11253961 2001
42
Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype. 61
10999835 2000
43
Monozygotic twinning: an evolutionary hypothesis. 61
7972065 1994
44
Effect of breast-feeding on pituitary-ovarian function after childbirth. 61
1182476 1975

Variations for Twinning, Dizygotic

ClinVar genetic disease variations for Twinning, Dizygotic:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 FSHR NM_000145.3(FSHR):c.919G>A (p.Ala307Thr) SNV drug response 16246 rs6165 GRCh37: 2:49191041-49191041
GRCh38: 2:48963902-48963902
2 FSHR NM_000145.4(FSHR):c.1121T>A (p.Ile374Asn) SNV Uncertain significance 812692 GRCh37: 2:49190839-49190839
GRCh38: 2:48963700-48963700

Expression for Twinning, Dizygotic

Search GEO for disease gene expression data for Twinning, Dizygotic.

Pathways for Twinning, Dizygotic

Pathways related to Twinning, Dizygotic according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 INHA FSHR

GO Terms for Twinning, Dizygotic

Biological processes related to Twinning, Dizygotic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 8.96 INHA FSHR
2 ovarian follicle development GO:0001541 8.62 INHA FSHR

Sources for Twinning, Dizygotic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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