MCID: TYM002
MIFTS: 25

Tympanic Membrane Disease

Categories: Ear diseases

Aliases & Classifications for Tympanic Membrane Disease

MalaCards integrated aliases for Tympanic Membrane Disease:

Name: Tympanic Membrane Disease 12 15 17
Disorder of Tympanic Membrane 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5782
ICD9CM 35 384.9
SNOMED-CT 68 21426000
UMLS 72 C0041825

Summaries for Tympanic Membrane Disease

MalaCards based summary : Tympanic Membrane Disease, also known as disorder of tympanic membrane, is related to tympanosclerosis and myringitis bullosa hemorrhagica, and has symptoms including tinnitus, earache and paracousis. An important gene associated with Tympanic Membrane Disease is BCAT2 (Branched Chain Amino Acid Transaminase 2), and among its related pathways/superpathways are Phospholipase-C Pathway and PI3K-Akt signaling pathway. Related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Tympanic Membrane Disease

Diseases related to Tympanic Membrane Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 tympanosclerosis 28.3 SPP1 COL4A1 COL2A1
2 myringitis bullosa hemorrhagica 11.3
3 otitis media 9.9
4 bone disease 9.5 SPP1 COL2A1

Symptoms & Phenotypes for Tympanic Membrane Disease

UMLS symptoms related to Tympanic Membrane Disease:


tinnitus, earache, paracousis, dysacusis

MGI Mouse Phenotypes related to Tympanic Membrane Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.72 ATP7A BCAT2 COL2A1 COL4A1 SPP1
2 growth/size/body region MP:0005378 9.65 ATP7A BCAT2 COL2A1 COL4A1 SPP1
3 mortality/aging MP:0010768 9.63 ATP7A BCAT2 COL2A1 COL4A1 MTFMT SPP1
4 renal/urinary system MP:0005367 9.35 ATP7A BCAT2 COL2A1 COL4A1 SPP1
5 respiratory system MP:0005388 8.92 ATP7A COL2A1 COL4A1 SPP1

Drugs & Therapeutics for Tympanic Membrane Disease

Search Clinical Trials , NIH Clinical Center for Tympanic Membrane Disease

Genetic Tests for Tympanic Membrane Disease

Anatomical Context for Tympanic Membrane Disease

Publications for Tympanic Membrane Disease

Articles related to Tympanic Membrane Disease:

# Title Authors PMID Year
1
Acquired cholesteatoma pathogenesis: stepwise explanations. 38
20156369 2010
2
Randomized, double-blind study of the clinical efficacy of 3 days of azithromycin compared with co-amoxiclav for the treatment of acute otitis media. 38
12888586 2003
3
Quantitative analysis of tympanic membrane disease using video-otoscopy. 38
11037834 2000
4
[Tensive disorder of tympanic membrane due to fenestration and its avoidance]. 38
13200937 1954

Variations for Tympanic Membrane Disease

Expression for Tympanic Membrane Disease

Search GEO for disease gene expression data for Tympanic Membrane Disease.

Pathways for Tympanic Membrane Disease

GO Terms for Tympanic Membrane Disease

Cellular components related to Tympanic Membrane Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basement membrane GO:0005604 9.16 COL4A1 COL2A1
2 collagen trimer GO:0005581 8.96 COL4A1 COL2A1
3 endoplasmic reticulum lumen GO:0005788 8.8 SPP1 COL4A1 COL2A1

Biological processes related to Tympanic Membrane Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cartilage development GO:0051216 9.26 COL2A1 ATP7A
2 cellular response to amino acid stimulus GO:0071230 9.16 COL4A1 ATP7A
3 collagen fibril organization GO:0030199 8.96 COL2A1 ATP7A
4 extracellular matrix organization GO:0030198 8.92 SPP1 COL4A1 COL2A1 ATP7A

Molecular functions related to Tympanic Membrane Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.16 COL4A1 COL2A1
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.96 COL4A1 COL2A1
3 platelet-derived growth factor binding GO:0048407 8.62 COL4A1 COL2A1

Sources for Tympanic Membrane Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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