Tympanic Membrane Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Tympanic Membrane Disease

MalaCards integrated aliases for Tympanic Membrane Disease:

Name: Tympanic Membrane Disease ¹² ¹⁵ ¹⁷

Disorder of Tympanic Membrane ⁷²

Classifications:

MalaCards categories:
Anatomical: Ear diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the ear and mastoid process

Diseases of middle ear and mastoid

Other disorders of tympanic membrane

Disorder of tympanic membrane, unspecified

Other specified disorders of tympanic membrane

External Ids:

Disease Ontology ¹² DOID:5782

ICD9CM ³⁵ 384.9

SNOMED-CT ⁶⁸ 21426000

ICD10 ³³ H73 H73.8 H73.9 more

EFO ¹⁷ EFO_0009570

UMLS ⁷² C0041825

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Summaries for Tympanic Membrane Disease

MalaCards based summary : Tympanic Membrane Disease, also known as disorder of tympanic membrane, is related to tympanosclerosis and myringitis bullosa hemorrhagica, and has symptoms including tinnitus, earache and paracousis. An important gene associated with Tympanic Membrane Disease is BCAT2 (Branched Chain Amino Acid Transaminase 2), and among its related pathways/superpathways are Phospholipase-C Pathway and PI3K-Akt signaling pathway. Related phenotypes are behavior/neurological and growth/size/body region

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Related Diseases for Tympanic Membrane Disease

Diseases related to Tympanic Membrane Disease via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	tympanosclerosis	28.3	SPP1 COL4A1 COL2A1
2	myringitis bullosa hemorrhagica	11.3
3	otitis media	9.9
4	bone disease	9.5	SPP1 COL2A1

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Symptoms & Phenotypes for Tympanic Membrane Disease

UMLS symptoms related to Tympanic Membrane Disease:

tinnitus, earache, paracousis, dysacusis

MGI Mouse Phenotypes related to Tympanic Membrane Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.72	ATP7A BCAT2 COL2A1 COL4A1 SPP1
2	growth/size/body region	MP:0005378	9.65	ATP7A BCAT2 COL2A1 COL4A1 SPP1
3	mortality/aging	MP:0010768	9.63	ATP7A BCAT2 COL2A1 COL4A1 MTFMT SPP1
4	renal/urinary system	MP:0005367	9.35	ATP7A BCAT2 COL2A1 COL4A1 SPP1
5	respiratory system	MP:0005388	8.92	ATP7A COL2A1 COL4A1 SPP1

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Drugs & Therapeutics for Tympanic Membrane Disease

Search Clinical Trials , NIH Clinical Center for Tympanic Membrane Disease

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Genetic Tests for Tympanic Membrane Disease

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Anatomical Context for Tympanic Membrane Disease

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Publications for Tympanic Membrane Disease

Articles related to Tympanic Membrane Disease:

#	Title	Authors	PMID	Year
1	Acquired cholesteatoma pathogenesis: stepwise explanations. ³⁸	Louw L	20156369	2010
2	Randomized, double-blind study of the clinical efficacy of 3 days of azithromycin compared with co-amoxiclav for the treatment of acute otitis media. ³⁸	Dunne MW...Shemer A	12888586	2003
3	Quantitative analysis of tympanic membrane disease using video-otoscopy. ³⁸	Jaisinghani VJ...Margolis RH	11037834	2000
4	[Tensive disorder of tympanic membrane due to fenestration and its avoidance]. ³⁸	ALBRECHT R	13200937	1954

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Genes for Tympanic Membrane Disease

Genes related to Tympanic Membrane Disease (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BCAT2	Branched Chain Amino Acid Transaminase 2	Protein Coding	15.59	DISEASES inferred ¹⁵
2	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	14.95	DISEASES inferred ¹⁵
3	MTFMT	Mitochondrial Methionyl-TRNA Formyltransferase	Protein Coding	14.94	DISEASES inferred ¹⁵
4	ATP7A	ATPase Copper Transporting Alpha	Protein Coding	14.66	DISEASES inferred ¹⁵
5	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	14.55	DISEASES inferred ¹⁵
6	SPP1	Secreted Phosphoprotein 1	Protein Coding	14.55	DISEASES inferred ¹⁵

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Variations for Tympanic Membrane Disease

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Expression for Tympanic Membrane Disease

Search GEO for disease gene expression data for Tympanic Membrane Disease.

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Pathways for Tympanic Membrane Disease

Pathways related to Tympanic Membrane Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	12.55	SPP1 COL4A1 COL2A1
2	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.47	SPP1 COL4A1 COL2A1
3	Focal Adhesion ³⁷ ¹ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.35	SPP1 COL4A1 COL2A1
4	Degradation of the extracellular matrix ⁶⁶ Show member pathways Collagen degradation ⁶⁶ Extracellular matrix organization ⁶⁶	12.09	SPP1 COL4A1 COL2A1
5	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²² Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²²	11.65	SPP1 COL4A1 COL2A1
6	Spinal Cord Injury ¹	11.51	COL4A1 COL2A1
7	ECM-receptor interaction ³⁷ Show member pathways Integrin cell surface interactions ⁶⁶	10.99	SPP1 COL4A1 COL2A1
8	Endochondral Ossification ¹	10.97	SPP1 COL2A1
9	Cell adhesion_ECM remodeling ²²	10.74	COL4A1 COL2A1
10	G-protein signaling_Rap2B regulation pathway ²²	10.4	SPP1 COL4A1 COL2A1

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GO Terms for Tympanic Membrane Disease

Cellular components related to Tympanic Membrane Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	basement membrane	GO:0005604	9.16	COL4A1 COL2A1
2	collagen trimer	GO:0005581	8.96	COL4A1 COL2A1
3	endoplasmic reticulum lumen	GO:0005788	8.8	SPP1 COL4A1 COL2A1

Biological processes related to Tympanic Membrane Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cartilage development	GO:0051216	9.26	COL2A1 ATP7A
2	cellular response to amino acid stimulus	GO:0071230	9.16	COL4A1 ATP7A
3	collagen fibril organization	GO:0030199	8.96	COL2A1 ATP7A
4	extracellular matrix organization	GO:0030198	8.92	SPP1 COL4A1 COL2A1 ATP7A

Molecular functions related to Tympanic Membrane Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent	GO:0005201	9.16	COL4A1 COL2A1
2	extracellular matrix structural constituent conferring tensile strength	GO:0030020	8.96	COL4A1 COL2A1
3	platelet-derived growth factor binding	GO:0048407	8.62	COL4A1 COL2A1

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Sources for Tympanic Membrane Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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¹⁶ DrugBank

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

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³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁴ MeSH

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⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia