MCID: TYM002
MIFTS: 22

Tympanic Membrane Disease

Categories: Ear diseases

Aliases & Classifications for Tympanic Membrane Disease

MalaCards integrated aliases for Tympanic Membrane Disease:

Name: Tympanic Membrane Disease 12 15
Disorder of Tympanic Membrane 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5782
ICD9CM 35 384.9
SNOMED-CT 68 21426000
UMLS 73 C0041825

Summaries for Tympanic Membrane Disease

MalaCards based summary : Tympanic Membrane Disease, also known as disorder of tympanic membrane, is related to myringitis bullosa hemorrhagica and tympanosclerosis, and has symptoms including tinnitus, earache and paracousis. An important gene associated with Tympanic Membrane Disease is BCAT2 (Branched Chain Amino Acid Transaminase 2), and among its related pathways/superpathways are PI3K-Akt signaling pathway and ECM-receptor interaction. Related phenotype is renal/urinary system.

Related Diseases for Tympanic Membrane Disease

Diseases related to Tympanic Membrane Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 myringitis bullosa hemorrhagica 11.2
2 tympanosclerosis 9.8 COL2A1 COL4A1
3 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.8 COL4A1 NOTCH1
4 autosomal dominant disease 9.7 COL2A1 COL4A1

Symptoms & Phenotypes for Tympanic Membrane Disease

UMLS symptoms related to Tympanic Membrane Disease:


tinnitus, earache, paracousis, dysacusis

MGI Mouse Phenotypes related to Tympanic Membrane Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 BCAT2 COL2A1 COL4A1 NOTCH1

Drugs & Therapeutics for Tympanic Membrane Disease

Search Clinical Trials , NIH Clinical Center for Tympanic Membrane Disease

Genetic Tests for Tympanic Membrane Disease

Anatomical Context for Tympanic Membrane Disease

Publications for Tympanic Membrane Disease

Articles related to Tympanic Membrane Disease:

# Title Authors Year
1
Quantitative analysis of tympanic membrane disease using video-otoscopy. ( 11037834 )
2000

Variations for Tympanic Membrane Disease

Expression for Tympanic Membrane Disease

Search GEO for disease gene expression data for Tympanic Membrane Disease.

Pathways for Tympanic Membrane Disease

Pathways related to Tympanic Membrane Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.27 COL2A1 COL4A1 NOTCH1
2
Show member pathways
11.5 COL2A1 COL4A1
3 11.23 COL2A1 COL4A1
4 10.96 COL2A1 NOTCH1
5 10.41 COL2A1 COL4A1

GO Terms for Tympanic Membrane Disease

Cellular components related to Tympanic Membrane Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basement membrane GO:0005604 8.96 COL2A1 COL4A1
2 collagen trimer GO:0005581 8.62 COL2A1 COL4A1

Molecular functions related to Tympanic Membrane Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.16 COL2A1 COL4A1
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.96 COL2A1 COL4A1
3 platelet-derived growth factor binding GO:0048407 8.62 COL2A1 COL4A1

Sources for Tympanic Membrane Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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