MCID: TYM002
MIFTS: 22

Tympanic Membrane Disease

Categories: Ear diseases

Aliases & Classifications for Tympanic Membrane Disease

MalaCards integrated aliases for Tympanic Membrane Disease:

Name: Tympanic Membrane Disease 12 15 17
Disorder of Tympanic Membrane 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5782
ICD9CM 34 384.9
SNOMED-CT 67 21426000
UMLS 71 C0041825

Summaries for Tympanic Membrane Disease

MalaCards based summary : Tympanic Membrane Disease, also known as disorder of tympanic membrane, is related to tympanosclerosis and myringitis bullosa hemorrhagica, and has symptoms including tinnitus, earache and paracousis. An important gene associated with Tympanic Membrane Disease is OXGR1 (Oxoglutarate Receptor 1). Related phenotypes are immune system and hearing/vestibular/ear

Related Diseases for Tympanic Membrane Disease

Diseases related to Tympanic Membrane Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 tympanosclerosis 29.6 OXGR1 COL2A1
2 myringitis bullosa hemorrhagica 11.3
3 otitis media 9.9
4 congenital nervous system abnormality 9.6 TGIF1 MCPH1

Symptoms & Phenotypes for Tympanic Membrane Disease

UMLS symptoms related to Tympanic Membrane Disease:


tinnitus, earache, paracousis, dysacusis

MGI Mouse Phenotypes related to Tympanic Membrane Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.87 COL2A1 FBXO11 MCPH1 OXGR1 RPL38 SH3PXD2B
2 hearing/vestibular/ear MP:0005377 9.85 COL2A1 FBXO11 MCPH1 RPL38 SH3PXD2B TGIF1
3 mortality/aging MP:0010768 9.81 BPIFA3 COL2A1 FBXO11 MCPH1 MTFMT RPL38
4 craniofacial MP:0005382 9.8 COL2A1 FBXO11 RPL38 SH3PXD2B TGIF1
5 limbs/digits/tail MP:0005371 9.65 COL2A1 FBXO11 RPL38 SH3PXD2B TGIF1
6 reproductive system MP:0005389 9.43 BPIFA3 MCPH1 RPL38 SH3PXD2B SPAG6 TGIF1
7 skeleton MP:0005390 9.17 COL2A1 FBXO11 MCPH1 RPL38 SDSL SH3PXD2B

Drugs & Therapeutics for Tympanic Membrane Disease

Search Clinical Trials , NIH Clinical Center for Tympanic Membrane Disease

Genetic Tests for Tympanic Membrane Disease

Anatomical Context for Tympanic Membrane Disease

Publications for Tympanic Membrane Disease

Articles related to Tympanic Membrane Disease:

# Title Authors PMID Year
1
Acquired cholesteatoma pathogenesis: stepwise explanations. 61
20156369 2010
2
Randomized, double-blind study of the clinical efficacy of 3 days of azithromycin compared with co-amoxiclav for the treatment of acute otitis media. 61
12888586 2003
3
Quantitative analysis of tympanic membrane disease using video-otoscopy. 61
11037834 2000
4
[Tensive disorder of tympanic membrane due to fenestration and its avoidance]. 61
13200937 1954

Variations for Tympanic Membrane Disease

Expression for Tympanic Membrane Disease

Search GEO for disease gene expression data for Tympanic Membrane Disease.

Pathways for Tympanic Membrane Disease

GO Terms for Tympanic Membrane Disease

Biological processes related to Tympanic Membrane Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.33 SH3PXD2B RPL38 COL2A1
2 skeletal system morphogenesis GO:0048705 9.26 SH3PXD2B COL2A1
3 sensory perception of sound GO:0007605 9.13 RPL38 FBXO11 COL2A1
4 bone development GO:0060348 8.8 SH3PXD2B MCPH1 COL2A1

Sources for Tympanic Membrane Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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