Aliases & Classifications for Tympanosclerosis

MalaCards integrated aliases for Tympanosclerosis:

Name: Tympanosclerosis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1214
ICD9CM 35 385.09
SNOMED-CT 68 111540000
ICD10 33 H74.0

Summaries for Tympanosclerosis

MalaCards based summary : Tympanosclerosis is related to deafness, progressive, with stapes fixation and tympanic membrane disease. An important gene associated with Tympanosclerosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. Affiliated tissues include bone, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

Related Diseases for Tympanosclerosis

Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 deafness, progressive, with stapes fixation 11.0
2 tympanic membrane disease 10.3 COL2A1 SPP1
3 otitis media 10.3
4 diastrophic dysplasia 10.2 BMP2 COL2A1
5 ischemic bone disease 10.2 BMP2 COL2A1
6 bone deterioration disease 10.2 BMP2 COL2A1
7 bone structure disease 10.2 BMP2 COL2A1
8 osteofibrous dysplasia 10.1 BMP2 SPP1
9 pilomyxoid astrocytoma 10.1 COL1A1 COL2A1
10 osteonecrosis 10.0 BMP2 COL2A1
11 spondyloepiphyseal dysplasia congenita 10.0 COL1A1 COL2A1
12 aortic valve disease 1 10.0 BMP2 SPP1
13 bone development disease 10.0 COL1A1 COL2A1
14 dentinogenesis imperfecta 10.0 COL1A1 SPP1
15 collagen disease 10.0 COL1A1 COL2A1
16 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
17 pneumonia 10.0
18 aortic valve disease 2 9.9 BMP2 SPP1
19 brittle bone disorder 9.9 COL1A1 COL2A1
20 autosomal dominant disease 9.8 COL2A1 COL4A1
21 chlamydia 9.8
22 suppurative otitis media 9.8
23 carotid stenosis 9.8
24 auditory system disease 9.8
25 middle ear disease 9.8
26 eustachian tube disease 9.8
27 perilymphatic fistula 9.8
28 bone fracture 9.7 BMP2 TLR4
29 otosclerosis 9.7 BMP2 COL1A1
30 bone disease 9.6 COL1A1 COL2A1 SPP1
31 synovial chondromatosis 9.5 BMP2 COL1A1 COL2A1
32 brachydactyly 9.5 BMP2 COL2A1
33 bone resorption disease 9.5 BMP2 COL1A1 SPP1
34 trehalase deficiency 9.0 COL1A1 COL2A1 COL4A1
35 osteoporosis 9.0 BMP2 COL1A1 COL2A1 SPP1

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to Tympanosclerosis

Symptoms & Phenotypes for Tympanosclerosis

MGI Mouse Phenotypes related to Tympanosclerosis:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 TLR4 SPP1 COL1A1 COL4A1 BMP2 COL2A1
2 cellular MP:0005384 10.05 SPP1 COL4A1 TLR4 COL2A1 COL1A1 BMP2
3 growth/size/body region MP:0005378 10.02 SPP1 COL4A1 TLR4 COL2A1 COL1A1 BMP2
4 behavior/neurological MP:0005386 9.99 SPP1 COL4A1 TLR4 COL2A1 COL1A1
5 homeostasis/metabolism MP:0005376 9.99 SPP1 COL4A1 TLR4 BMP2 COL2A1 COL1A1
6 immune system MP:0005387 9.97 TLR4 SPP1 COL2A1 COL1A1 COL4A1 BMP2
7 hematopoietic system MP:0005397 9.92 SPP1 COL4A1 TLR4 BMP2 COL1A1
8 mortality/aging MP:0010768 9.91 SPP1 COL4A1 TLR4 BMP2 COL2A1 COL1A1
9 craniofacial MP:0005382 9.87 SPP1 BMP2 COL2A1 COL1A1
10 digestive/alimentary MP:0005381 9.86 TLR4 BMP2 COL2A1 COL1A1
11 nervous system MP:0003631 9.85 TLR4 SPP1 COL2A1 COL1A1 COL4A1 BMP2
12 hearing/vestibular/ear MP:0005377 9.84 TLR4 COL2A1 COL1A1 BMP2
13 limbs/digits/tail MP:0005371 9.78 TLR4 BMP2 COL2A1 COL1A1
14 liver/biliary system MP:0005370 9.76 SPP1 TLR4 COL2A1 COL1A1
15 renal/urinary system MP:0005367 9.72 TLR4 SPP1 COL1A1 COL4A1 COL2A1
16 muscle MP:0005369 9.71 SPP1 COL4A1 TLR4 COL1A1
17 reproductive system MP:0005389 9.65 SPP1 COL4A1 TLR4 COL1A1 BMP2
18 respiratory system MP:0005388 9.55 TLR4 SPP1 COL1A1 COL4A1 COL2A1
19 skeleton MP:0005390 9.35 SPP1 TLR4 COL2A1 COL1A1 BMP2
20 vision/eye MP:0005391 8.92 TLR4 COL4A1 COL2A1 COL1A1

Drugs & Therapeutics for Tympanosclerosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c Completed NCT00422851

Search NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

Anatomical Context for Tympanosclerosis

MalaCards organs/tissues related to Tympanosclerosis:

41
Bone

Publications for Tympanosclerosis

Articles related to Tympanosclerosis:

(show top 50) (show all 149)
# Title Authors Year
1
Stapes Release in Tympanosclerosis. ( 29210944 )
2018
2
Possible role of Dickkopf-1 protein in the pathogenesis of tympanosclerosis in a rat model. ( 28807065 )
2017
3
Gene expression profile of collagen types, osteopontin in the tympanic membrane of patients with tympanosclerosis. ( 29068597 )
2017
4
The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. ( 28576521 )
2017
5
Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients. ( 27534583 )
2016
6
Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis. ( 27959908 )
2016
7
Neuroglial Choristoma of the Middle Ear with Massive Tympanosclerosis: A Case Report and Literature Review. ( 27942605 )
2016
8
Tympanosclerosis Presenting as Mass: Workup and Differential. ( 27656306 )
2016
9
The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats. ( 27484331 )
2016
10
Correlation Between Tympanosclerosis and Helicobacter pylori. ( 26568799 )
2015
11
Manubrio-stapedioplasty: new surgical technique for malleus and incus fixation due to tympanosclerosis. ( 25883094 )
2015
12
Does systemic clarithromycin therapy have an inhibitory effect on tympanosclerosis? An experimental animal study. ( 25619629 )
2015
13
Role of Chlamydia pneumoniae and Helicobacteria pylori in the development of tympanosclerosis. ( 25956614 )
2015
14
Increased carotid artery intima-media thickness in patients with tympanosclerosis: Common risk factors with atherosclerosis? ( 25835276 )
2015
15
An Analysis of Surgical Treatment Results of Patients With Tympanosclerosis. ( 26517462 )
2015
16
Efficacy of pre-operative computed tomography evaluation of the tympanic cavity for hearing improvement after stapes surgery for tympanosclerosis with stapes fixation. ( 25706157 )
2015
17
Combining Use of Captopril and Losartan Attenuates the Progress of Streptococcus pneumoniae-Induced Tympanosclerosis through the Suppression of TGF-I^1 Expression. ( 25360706 )
2014
18
The effect of stapes fixation on hearing results in tympanosclerosis treated by mobilization. ( 25472817 )
2014
19
Surgery of isolated malleus fixation due to tympanosclerosis. ( 25503358 )
2014
20
Immunohistochemical investigation of inducible nitric oxide synthase, osteopontin, and calcium-sensing receptor in a myringosclerosis/tympanosclerosis model. ( 24136309 )
2014
21
PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media. ( 25399881 )
2014
22
Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study. ( 24134073 )
2013
23
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. ( 22777961 )
2012
24
Experience with the Vibrant Soundbridge RW-Coupler for round window Vibroplasty with tympanosclerosis. ( 22385350 )
2012
25
[Assessment of Tumor Necrosis Factor alpha gene expression profile in selected structures of middle ear in patients with tympanosclerosis]. ( 23164102 )
2012
26
Serum matrix metalloproteinases and tympanosclerosis. ( 20955636 )
2011
27
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? ( 21888743 )
2011
28
Tympanosclerosis and our surgical results. ( 19771442 )
2010
29
Clinical analysis of intratympanic tympanosclerosis: etiology, ossicular chain findings, and hearing results of surgery. ( 19685361 )
2010
30
Evaluation of the polymorphism in the Toll-like receptor 4 (TLR4) genes of tympanosclerosis patients. ( 19398177 )
2010
31
Is there any relation between coronary atherosclerosis and tympanosclerosis? ( 20382609 )
2010
32
[Expression and localization of macrophages and BMP2 in mucosa of tympanosclerosis]. ( 19670606 )
2009
33
A computational method for the semi-automated quantitative analysis of tympanic membrane perforations and tympanosclerosis. ( 19643399 )
2009
34
Hearing results of surgery for tympanosclerosis. ( 18704475 )
2009
35
Analysis of long-term hearing after tympanosclerosis with total/partial stapedectomy and prosthesis used. ( 18607937 )
2008
36
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. ( 18945497 )
2008
37
Topical application of calcium channel blockers to reduce the progression of experimentally induced myringosclerosis and tympanosclerosis. ( 18176349 )
2008
38
Stapedectomy in tympanosclerosis, hearing results. ( 18454228 )
2008
39
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. ( 18388770 )
2008
40
The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosis. ( 18394718 )
2008
41
Evaluation of plasma fibronectine level as a probable indicator for tympanosclerosis. ( 17470306 )
2008
42
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. ( 17963670 )
2007
43
Malleostapedotomy in tympanosclerosis patients. ( 17524174 )
2007
44
Influence of hypercalcemia in the formation of tympanosclerosis in rats. ( 16371843 )
2006
45
Tympanosclerosis revisited. ( 23120263 )
2006
46
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. ( 16923708 )
2006
47
An analysis of the single-stage tympanoplasty with over-underlay grafting in tympanosclerosis. ( 15129093 )
2004
48
Is carotid stenosis correlated with tympanosclerosis. ( 15507892 )
2004
49
Possible relationship between tympanosclerosis and atherosclerosis. ( 15267174 )
2004
50
Comparison of free radicals and antioxidant enzymes in chronic otitis media with and without tympanosclerosis. ( 14710000 )
2004

Variations for Tympanosclerosis

Expression for Tympanosclerosis

Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for Tympanosclerosis

Pathways related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.42 BMP2 COL1A1 COL2A1 COL4A1 SPP1
2
Show member pathways
13.01 COL1A1 COL2A1 COL4A1 SPP1
3
Show member pathways
12.55 BMP2 COL1A1 COL2A1 COL4A1 SPP1
4
Show member pathways
12.5 COL1A1 COL2A1 COL4A1 SPP1
5
Show member pathways
12.47 COL1A1 COL2A1 COL4A1
6
Show member pathways
12.38 COL1A1 COL2A1 COL4A1 SPP1 TLR4
7
Show member pathways
12.27 COL1A1 COL2A1 COL4A1
8
Show member pathways
11.68 BMP2 COL1A1 COL2A1 COL4A1 SPP1
9 11.66 COL2A1 COL4A1 TLR4
10 11.62 BMP2 COL1A1
11
Show member pathways
11.61 COL1A1 COL4A1
12 11.58 COL1A1 COL4A1
13 11.53 COL1A1 COL4A1 TLR4
14
Show member pathways
11.43 COL1A1 COL2A1 COL4A1 SPP1
15 11.36 COL2A1 SPP1
16 11.28 COL1A1 COL2A1 COL4A1
17 11.23 COL1A1 COL4A1
18 11.16 COL1A1 SPP1
19 11.1 COL1A1 COL4A1
20 11.07 COL1A1 SPP1
21 10.78 BMP2 COL2A1

GO Terms for Tympanosclerosis

Cellular components related to Tympanosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.72 BMP2 COL1A1 COL2A1 COL4A1 SPP1
2 extracellular space GO:0005615 9.55 BMP2 COL1A1 COL2A1 COL4A1 SPP1
3 extracellular matrix GO:0031012 9.43 COL1A1 COL2A1 COL4A1
4 basement membrane GO:0005604 9.37 COL2A1 COL4A1
5 collagen trimer GO:0005581 9.13 COL1A1 COL2A1 COL4A1
6 endoplasmic reticulum lumen GO:0005788 8.92 COL1A1 COL2A1 COL4A1 SPP1

Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.77 BMP2 COL1A1 SPP1
2 inflammatory response GO:0006954 9.75 BMP2 SPP1 TLR4
3 activation of MAPK activity GO:0000187 9.61 BMP2 TLR4
4 skeletal system development GO:0001501 9.61 BMP2 COL1A1 COL2A1
5 cellular response to mechanical stimulus GO:0071260 9.59 COL1A1 TLR4
6 cartilage development GO:0051216 9.58 BMP2 COL2A1
7 inner ear development GO:0048839 9.57 BMP2 COL2A1
8 cellular response to amino acid stimulus GO:0071230 9.56 COL1A1 COL4A1
9 positive regulation of epithelial to mesenchymal transition GO:0010718 9.55 BMP2 COL1A1
10 collagen fibril organization GO:0030199 9.54 COL1A1 COL2A1
11 skeletal system morphogenesis GO:0048705 9.52 COL1A1 COL2A1
12 chondrocyte differentiation GO:0002062 9.51 BMP2 COL2A1
13 osteoblast differentiation GO:0001649 9.5 BMP2 COL1A1 SPP1
14 cellular response to BMP stimulus GO:0071773 9.49 BMP2 COL2A1
15 response to steroid hormone GO:0048545 9.48 COL1A1 SPP1
16 endochondral ossification GO:0001958 9.46 COL1A1 COL2A1
17 ossification GO:0001503 9.43 BMP2 COL1A1 COL2A1
18 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.4 COL1A1 COL4A1
19 proteoglycan metabolic process GO:0006029 9.37 BMP2 COL2A1
20 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.16 COL1A1 COL2A1
21 collagen catabolic process GO:0030574 9.13 COL1A1 COL2A1 COL4A1
22 extracellular matrix organization GO:0030198 8.92 COL1A1 COL2A1 COL4A1 SPP1

Molecular functions related to Tympanosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.13 COL1A1 COL2A1 COL4A1
2 platelet-derived growth factor binding GO:0048407 8.8 COL1A1 COL2A1 COL4A1

Sources for Tympanosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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