MCID: TYM001
MIFTS: 36

Tympanosclerosis

Categories: Ear diseases

Aliases & Classifications for Tympanosclerosis

MalaCards integrated aliases for Tympanosclerosis:

Name: Tympanosclerosis 12 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:1214
ICD9CM 34 385.09
SNOMED-CT 67 111540000
ICD10 32 H74.0
UMLS 70 C0155477 C0395887

Summaries for Tympanosclerosis

MalaCards based summary : Tympanosclerosis is related to otosclerosis and chlamydia pneumonia. An important gene associated with Tympanosclerosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Phospholipase-C Pathway. Affiliated tissues include bone and tongue, and related phenotypes are cellular and cardiovascular system

Wikipedia : 73 | name = | synonyms = Myringosclerosis, intratympanic tympanosclerosis | field = ENT surgery | symptoms... more...

Related Diseases for Tympanosclerosis

Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 otosclerosis 30.1 COL1A1 CALCA BMP2
2 chlamydia pneumonia 30.0 TNF TLR4
3 chlamydia 29.4 TNF TLR4 NOS2
4 deafness, progressive, with stapes fixation 10.9
5 otitis media 10.7
6 cholesteatoma of middle ear 10.5
7 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
8 sensorineural hearing loss 10.3
9 suppurative otitis media 10.3
10 chronic purulent otitis media 10.3
11 calcific tendinitis 10.3 SPP1 BMP2
12 dyssegmental dysplasia, silverman-handmaker type 10.3 COL2A1 BMP2
13 pouchitis 10.2 TNF TLR4
14 spondylarthropathy 10.2 TNF TLR4
15 congenital cytomegalovirus 10.2 TNF TLR4
16 superficial basal cell carcinoma 10.2 TNF TLR4
17 enterocolitis 10.2 TNF TLR4
18 osteofibrous dysplasia 10.2 SPP1 BMP2
19 autoimmune myocarditis 10.2 TNF SPP1
20 pneumonic tularemia 10.2 TNF TLR4
21 tularemia 10.2 TNF TLR4
22 dental pulp necrosis 10.2 TNF BMP2
23 pneumonic plague 10.2 TNF TLR4
24 middle ear disease 10.2
25 tendinitis 10.2 TNF SPP1
26 gingival recession 10.2 TNF BMP2
27 iridocyclitis 10.2 TNF TLR4
28 idiopathic neutropenia 10.2 TNF TLR4
29 urethritis 10.2 TNF TLR4
30 neurogenic arthropathy 10.2 COL2A1 CALCA
31 osteogenesis imperfecta, type vii 10.2 SPP1 COL1A1
32 hemorrhagic cystitis 10.2 TNF TLR4
33 chronic pyelonephritis 10.1 TLR4 CALCA
34 atherosclerosis susceptibility 10.1
35 urinary tract infection 10.1 TLR4 CAT
36 alveolar echinococcosis 10.1 TNF TLR4
37 x-linked alport syndrome 10.1 COL4A1 COL1A1
38 epicondylitis 10.1 COL1A1 CALCA
39 cervicitis 10.1 TNF TLR4
40 klebsiella pneumonia 10.1 TNF TLR4
41 synovial chondromatosis 10.1 COL2A1 COL1A1 BMP2
42 bronchopneumonia 10.1 TNF TLR4
43 dental pulp disease 10.1 TNF TLR4 BMP2
44 branchiootic syndrome 1 10.1
45 bone development disease 10.1 COL2A1 COL1A1 BMP2
46 bursitis 10.1 TNF CALCA
47 pyelitis 10.1 TNF TLR4
48 cartilage disease 10.1 TNF COL2A1 BMP2
49 cleidocranial dysplasia 10.1 SPP1 COL1A1 BMP2
50 achondroplasia 10.1 SPP1 COL2A1 COL1A1

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to Tympanosclerosis

Symptoms & Phenotypes for Tympanosclerosis

MGI Mouse Phenotypes related to Tympanosclerosis:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 BMP2 CAT COL1A1 COL2A1 COL4A1 NOS2
2 cardiovascular system MP:0005385 10.16 BMP2 COL1A1 COL2A1 COL4A1 NOS2 SPP1
3 homeostasis/metabolism MP:0005376 10.16 BMP2 CAT COL1A1 COL2A1 COL4A1 NOS2
4 mortality/aging MP:0010768 10.11 BMP2 CAT COL1A1 COL2A1 COL4A1 NOS2
5 immune system MP:0005387 10.1 BMP2 COL1A1 COL2A1 COL4A1 NOS2 SPP1
6 craniofacial MP:0005382 10.01 BMP2 COL1A1 COL2A1 NOS2 SPP1 TNF
7 digestive/alimentary MP:0005381 10 BMP2 COL1A1 COL2A1 NOS2 TLR4 TNF
8 nervous system MP:0003631 9.97 BMP2 COL1A1 COL2A1 COL4A1 NOS2 SPP1
9 liver/biliary system MP:0005370 9.95 COL1A1 COL2A1 NOS2 SPP1 TLR4 TNF
10 muscle MP:0005369 9.91 COL1A1 COL4A1 NOS2 SPP1 TLR4 TNF
11 neoplasm MP:0002006 9.88 CAT COL1A1 NOS2 SPP1 TLR4 TNF
12 renal/urinary system MP:0005367 9.8 COL1A1 COL2A1 COL4A1 NOS2 SPP1 TLR4
13 reproductive system MP:0005389 9.8 BMP2 COL1A1 COL4A1 NOS2 SPP1 TLR4
14 respiratory system MP:0005388 9.7 COL1A1 COL2A1 COL4A1 NOS2 SPP1 TLR4
15 skeleton MP:0005390 9.5 BMP2 COL1A1 COL2A1 NOS2 SPP1 TLR4
16 vision/eye MP:0005391 9.17 COL1A1 COL2A1 COL4A1 NOS2 SPP1 TLR4

Drugs & Therapeutics for Tympanosclerosis

Search Clinical Trials , NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

Anatomical Context for Tympanosclerosis

MalaCards organs/tissues related to Tympanosclerosis:

40
Bone, Tongue

Publications for Tympanosclerosis

Articles related to Tympanosclerosis:

(show top 50) (show all 449)
# Title Authors PMID Year
1
Quantitative assessment of cochlear and vestibular ganglion neurons in temporal bones with chronic otitis media. 61
32488375 2021
2
Endoscopic transcanal management of tympanosclerosis. 61
33609176 2021
3
The Possible Role of Sclerostin in the Pathogenesis of Tympanosclerosis. 61
33508832 2021
4
Role of TGF-β1-mediated epithelial-mesenchymal transition in the pathogenesis of tympanosclerosis. 61
33235615 2021
5
Digital Otoscopy Videos Versus Composite Images: A Reader Study to Compare the Accuracy of ENT Physicians. 61
33170529 2020
6
Tympanosclerosis and atherosclerosis plaques: a comparative analytical study on some new microbiological and immunohistochemical aspects. 61
33140144 2020
7
[An observation of long term effect of one-stage hearing reconstruction on tympanosclerosis]. 61
33254294 2020
8
[Short-term effect of endoscopic one-stage tympanoplasty on tympanosclerosis]. 61
33254290 2020
9
[The long term effect of malleostapedotomy in ossicular chain reconstruction]. 61
33254291 2020
10
Success rates for various graft materials in tympanoplasty - A review. 61
32884562 2020
11
Development and Validation of a Clinical Score for Predicting the Risk of Tympanosclerosis Before Surgery. 61
32894702 2020
12
Is ossicular chain fixation predictable for tympanosclerosis on preoperative temporal bone computed tomography? 61
32944833 2020
13
Type I Tympanoplasty: surgical success and prognostic factors. 61
32862972 2020
14
Use of Mesna in the treatment of ossicular chain fixation related to tympanosclerosis; prospective, clinical study. 61
32451291 2020
15
Outcomes Following Revision Stapes Surgery in Children: A Single-Surgeon, Single-Center 15-Year Experience. 61
32574481 2020
16
[The effect of one-stage tympanoplasty for stapes fixation with tympanosclerosis]. 61
32791632 2020
17
Microendoscopic Surgery of Middle Ear and Petrous Bone: Benefits Analysis. 61
32511009 2020
18
Factors affecting persistent tympanic membrane perforation after tympanostomy tube removal in children. 61
31786523 2020
19
Körner's septum (petrosquamosal lamina): the anatomical variant or clinical problem? 61
31448811 2020
20
Prevalence of Otitis Media with Effusion in Children with Hearing Loss. 61
31750164 2019
21
Clinical landmarks in chronic otitis media with tympanosclerosis: clinical history may have predictive value in the diagnosis of ossicular chain mobility. 61
31668158 2019
22
The Effect of Nasal Septal Deviation on the Postoperative Hearing Results of Patients With Tympanosclerosis. 61
31578106 2019
23
Outcomes of Primary Pediatric Stapedotomy. 61
31356485 2019
24
[A multi-center retrospective study of ossiculoplasty surgery under oto-endoscope in 45 cases of conductive hearing loss with intact tympanic membrane]. 61
30991774 2019
25
Comparison of the Aditus ad Antrum Diameter on CT between Patients with Chronic Otitis Media and Healthy Individuals. 61
32008526 2019
26
Tophaceous Gout of the Middle Ear: Case Reports and Review of the Literature. 61
31167187 2019
27
[Single-stage open tympanoplasty in the form of tympanosclerosis with fixation of the stapes]. 61
31198211 2019
28
[The role of stapedoplasty in the treatment of hearing impairment in the patients presenting with tympanosclerosis]. 61
30938334 2019
29
[Experiences of second type Ⅰ tympanoplasty]. 61
30716799 2018
30
Metagenomics Analysis of Bacterial Population of Tympanosclerotic Plaques and Cholesteatomas. 61
29688828 2018
31
[The study for the characteristics of secondary acquired cholesteatoma]. 61
30550167 2018
32
Idiopathic, Infectious and Reactive Lesions of the Ear and Temporal Bone. 61
30069844 2018
33
Histopathology of tympanic membranes from patients with ventilation tubes. 61
28774486 2018
34
Different concentrations of mesna application have an effect on the internal ear? 61
29728180 2018
35
[Transcanal endoscopic ear surgery for tympanosclerosis]. 61
29873208 2018
36
Ossicular Chain Reconstruction in a Developing Country. 61
29502435 2018
37
Tympanostomy tubes for serous otitis media and risk of recurrences. 61
29447881 2018
38
Stapes Release in Tympanosclerosis. 61
29210944 2018
39
Use of narrow band imaging and 4K technology in otology and neuro-otology: preliminary experience and feasibility study. 61
29080146 2018
40
Minimally invasive laser vibrometry (MIVIB) with a floating mass transducer - A new method for objective evaluation of the middle ear demonstrated on stapes fixation. 61
29190487 2018
41
Prevalence of chronic ear disease among HIV+ children in Sub-Saharan Africa. 61
29224754 2017
42
Possible role of Dickkopf-1 protein in the pathogenesis of tympanosclerosis in a rat model. 61
28807065 2017
43
The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats. 61
27484331 2017
44
Gene expression profile of collagen types, osteopontin in the tympanic membrane of patients with tympanosclerosis. 61
29068597 2017
45
The role of the nasal and paranasal sinus pathologies on the development of chronic otitis media and its subtypes: A computed tomography study. 61
29072240 2017
46
[Bone conduction in tympanosclerosis patients and its changes after surgery for tympanosclerosis]. 61
29798367 2017
47
The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. 61
28576521 2017
48
Felix tympanoplasty: functional results of a single surgeon's technique in the scope of a literature review on influencing factors. 61
29557559 2017
49
[Extragastric symptoms associated with Helicobacter pylori infection]. 61
30299058 2017
50
[The prevalence of tympanosclerosis and the effectiveness of its surgical treatment]. 61
28514355 2017

Variations for Tympanosclerosis

Expression for Tympanosclerosis

Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for Tympanosclerosis

Pathways related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 TNF SPP1 NOS2 COL4A1 COL2A1 COL1A1
2
Show member pathways
12.84 SPP1 COL4A1 COL2A1 COL1A1 BMP2
3
Show member pathways
12.68 SPP1 COL4A1 COL2A1 COL1A1
4
Show member pathways
12.63 TNF TLR4 SPP1 COL4A1 COL2A1 COL1A1
5
Show member pathways
12.46 SPP1 COL4A1 COL2A1 COL1A1 BMP2
6 12.1 TNF TLR4 COL1A1
7
Show member pathways
12.06 TNF TLR4 NOS2
8 12.03 TNF TLR4 NOS2
9 11.98 TNF TLR4 NOS2
10
Show member pathways
11.98 TNF TLR4 NOS2
11
Show member pathways
11.86 SPP1 COL4A1 COL2A1 COL1A1
12 11.71 TNF COL4A1 COL1A1
13 11.68 SPP1 COL2A1 BMP2
14 11.57 TNF TLR4 NOS2
15 11.49 TNF TLR4 NOS2
16 11.45 TNF SPP1 CALCA
17 11.43 TNF TLR4 NOS2 COL4A1 COL2A1
18 11.42 COL4A1 COL2A1 COL1A1
19 11.29 TNF TLR4 NOS2
20 11.11 TNF SPP1 COL1A1 CALCA
21 11.03 TNF TLR4 NOS2 COL4A1 COL1A1
22 10.9 COL2A1 BMP2
23 10.85 TNF COL4A1
24 10.64 TNF SPP1 COL4A1 COL2A1 COL1A1 BMP2

GO Terms for Tympanosclerosis

Cellular components related to Tympanosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 TNF SPP1 COL4A1 COL2A1 COL1A1 CAT
2 endoplasmic reticulum lumen GO:0005788 9.46 SPP1 COL4A1 COL2A1 COL1A1
3 collagen trimer GO:0005581 9.43 COL4A1 COL2A1 COL1A1
4 phagocytic cup GO:0001891 9.32 TNF TLR4
5 extracellular space GO:0005615 9.23 TNF SPP1 COL4A1 COL2A1 COL1A1 CAT

Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.86 TNF TLR4 RHOXF1 BMP2
2 response to hypoxia GO:0001666 9.77 NOS2 CAT BMP2
3 cellular response to lipopolysaccharide GO:0071222 9.74 TNF TLR4 NOS2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 TNF TLR4 CAT
5 skeletal system development GO:0001501 9.71 COL2A1 COL1A1 BMP2
6 activation of MAPK activity GO:0000187 9.7 TNF TLR4 BMP2
7 response to bacterium GO:0009617 9.67 TLR4 NOS2 BMP2
8 endochondral ossification GO:0001958 9.61 COL2A1 COL1A1
9 negative regulation of blood pressure GO:0045776 9.6 NOS2 CALCA
10 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.58 TNF TLR4
11 negative regulation of osteoclast differentiation GO:0045671 9.58 TLR4 CALCA
12 ossification GO:0001503 9.56 SPP1 COL2A1 COL1A1 BMP2
13 positive regulation of interleukin-8 production GO:0032757 9.54 TNF TLR4 CALCA
14 response to hyperoxia GO:0055093 9.51 COL1A1 CAT
15 cellular response to amino acid stimulus GO:0071230 9.5 TNF COL4A1 COL1A1
16 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.48 COL4A1 COL1A1
17 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.46 TNF TLR4
18 osteoblast differentiation GO:0001649 9.46 SPP1 COL1A1 CAT BMP2
19 proteoglycan metabolic process GO:0006029 9.43 COL2A1 BMP2
20 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.4 COL2A1 COL1A1
21 extracellular matrix organization GO:0030198 9.35 TNF SPP1 COL4A1 COL2A1 COL1A1
22 inflammatory response GO:0006954 9.1 TNF TLR4 SPP1 NOS2 CALCA BMP2

Molecular functions related to Tympanosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 TNF TLR4 COL2A1 COL1A1 CAT CALCA
2 extracellular matrix structural constituent GO:0005201 9.43 COL4A1 COL2A1 COL1A1
3 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL4A1 COL2A1 COL1A1
4 platelet-derived growth factor binding GO:0048407 8.8 COL4A1 COL2A1 COL1A1

Sources for Tympanosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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