MCID: TYM001
MIFTS: 35

Tympanosclerosis

Categories: Ear diseases

Aliases & Classifications for Tympanosclerosis

MalaCards integrated aliases for Tympanosclerosis:

Name: Tympanosclerosis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1214
ICD9CM 36 385.09
ICD10 34 H74.0

Summaries for Tympanosclerosis

MalaCards based summary : Tympanosclerosis is related to deafness, progressive, with stapes fixation and otitis media. An important gene associated with Tympanosclerosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. Related phenotypes are cardiovascular system and cellular

Wikipedia : 77 Tympanosclerosis is a condition caused by hyalinization and subsequent calcification of subepithelial... more...

Related Diseases for Tympanosclerosis

Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 deafness, progressive, with stapes fixation 11.2
2 otitis media 10.5
3 cholesteatoma of middle ear 10.3
4 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
5 tympanic membrane disease 10.2 COL2A1 COL4A1
6 spondylarthropathy 10.1 COL2A1 TLR4
7 pilomyxoid astrocytoma 10.0 COL1A1 COL2A1
8 chlamydia pneumonia 10.0
9 chlamydia 10.0
10 suppurative otitis media 10.0
11 carotid stenosis 10.0
12 chronic purulent otitis media 10.0
13 middle ear disease 10.0
14 eustachian tube disease 10.0
15 spondyloepiphyseal dysplasia congenita 10.0 COL1A1 COL2A1
16 bone development disease 10.0 COL1A1 COL2A1
17 autosomal dominant disease 10.0 COL2A1 COL4A1
18 dentinogenesis imperfecta 9.9 COL1A1 SPP1
19 brittle bone disorder 9.9 COL1A1 COL2A1
20 diastrophic dysplasia 9.9 BMP2 COL2A1
21 bone deterioration disease 9.9 BMP2 COL2A1
22 ischemic bone disease 9.9 BMP2 COL2A1
23 bone structure disease 9.9 BMP2 COL2A1
24 osteofibrous dysplasia 9.8 BMP2 SPP1
25 osteonecrosis 9.8 BMP2 COL2A1
26 arteriosclerosis 9.8 SPP1 TLR4
27 otosclerosis 9.8 BMP2 COL1A1
28 bone disease 9.8 COL1A1 COL2A1 SPP1
29 aortic valve disease 2 9.7 BMP2 SPP1
30 aortic valve disease 1 9.7 BMP2 SPP1
31 cerebrovascular disease 9.7 COL4A1 TLR4
32 synovial chondromatosis 9.6 BMP2 COL1A1 COL2A1
33 bone resorption disease 9.5 BMP2 COL1A1 SPP1
34 osteoporosis 9.4 BMP2 COL1A1 SPP1

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to Tympanosclerosis

Symptoms & Phenotypes for Tympanosclerosis

MGI Mouse Phenotypes related to Tympanosclerosis:

47 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 BMP2 COL1A1 COL2A1 COL4A1 SPP1 TLR4
2 cellular MP:0005384 10.05 BMP2 COL1A1 COL2A1 COL4A1 SPP1 TLR4
3 growth/size/body region MP:0005378 10.02 BMP2 COL1A1 COL2A1 COL4A1 SPP1 TLR4
4 behavior/neurological MP:0005386 9.99 COL1A1 COL2A1 COL4A1 SPP1 TLR4
5 homeostasis/metabolism MP:0005376 9.99 BMP2 COL1A1 COL2A1 COL4A1 SPP1 TLR4
6 immune system MP:0005387 9.97 BMP2 COL1A1 COL2A1 COL4A1 SPP1 TLR4
7 hematopoietic system MP:0005397 9.92 BMP2 COL1A1 COL4A1 SPP1 TLR4
8 mortality/aging MP:0010768 9.91 BMP2 COL1A1 COL2A1 COL4A1 SPP1 TLR4
9 craniofacial MP:0005382 9.87 BMP2 COL1A1 COL2A1 SPP1
10 digestive/alimentary MP:0005381 9.86 BMP2 COL1A1 COL2A1 TLR4
11 nervous system MP:0003631 9.85 BMP2 COL1A1 COL2A1 COL4A1 SPP1 TLR4
12 hearing/vestibular/ear MP:0005377 9.84 BMP2 COL1A1 COL2A1 TLR4
13 limbs/digits/tail MP:0005371 9.78 BMP2 COL1A1 COL2A1 TLR4
14 liver/biliary system MP:0005370 9.76 COL1A1 COL2A1 SPP1 TLR4
15 renal/urinary system MP:0005367 9.72 COL1A1 COL2A1 COL4A1 SPP1 TLR4
16 muscle MP:0005369 9.71 COL1A1 COL4A1 SPP1 TLR4
17 reproductive system MP:0005389 9.65 BMP2 COL1A1 COL4A1 SPP1 TLR4
18 respiratory system MP:0005388 9.55 COL1A1 COL2A1 COL4A1 SPP1 TLR4
19 skeleton MP:0005390 9.35 BMP2 COL1A1 COL2A1 SPP1 TLR4
20 vision/eye MP:0005391 8.92 COL1A1 COL2A1 COL4A1 TLR4

Drugs & Therapeutics for Tympanosclerosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c Completed NCT00422851

Search NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

Anatomical Context for Tympanosclerosis

Publications for Tympanosclerosis

Articles related to Tympanosclerosis:

(show top 50) (show all 151)
# Title Authors Year
1
Stapes Release in Tympanosclerosis. ( 29210944 )
2018
2
The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats. ( 27484331 )
2017
3
Gene expression profile of collagen types, osteopontin in the tympanic membrane of patients with tympanosclerosis. ( 29068597 )
2017
4
Possible role of Dickkopf-1 protein in the pathogenesis of tympanosclerosis in a rat model. ( 28807065 )
2017
5
The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. ( 28576521 )
2017
6
Tympanosclerosis Presenting as Mass: Workup and Differential. ( 27656306 )
2016
7
Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients. ( 27534583 )
2016
8
Neuroglial Choristoma of the Middle Ear with Massive Tympanosclerosis: A Case Report and Literature Review. ( 27942605 )
2016
9
Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis. ( 27959908 )
2016
10
Role of Chlamydia pneumoniae and Helicobacteria pylori in the development of tympanosclerosis. ( 25956614 )
2016
11
Correlation Between Tympanosclerosis and Helicobacter pylori. ( 26568799 )
2015
12
An Analysis of Surgical Treatment Results of Patients With Tympanosclerosis. ( 26517462 )
2015
13
Manubrio-stapedioplasty: new surgical technique for malleus and incus fixation due to tympanosclerosis. ( 25883094 )
2015
14
Increased carotid artery intima-media thickness in patients with tympanosclerosis: Common risk factors with atherosclerosis? ( 25835276 )
2015
15
Efficacy of pre-operative computed tomography evaluation of the tympanic cavity for hearing improvement after stapes surgery for tympanosclerosis with stapes fixation. ( 25706157 )
2015
16
Does systemic clarithromycin therapy have an inhibitory effect on tympanosclerosis? An experimental animal study. ( 25619629 )
2015
17
Surgery of isolated malleus fixation due to tympanosclerosis. ( 25503358 )
2015
18
The effect of stapes fixation on hearing results in tympanosclerosis treated by mobilization. ( 25472817 )
2015
19
Combining use of captopril and losartan attenuates the progress of Streptococcus pneumoniae-induced tympanosclerosis through the suppression of TGF-β1 expression. ( 25360706 )
2014
20
Immunohistochemical investigation of inducible nitric oxide synthase, osteopontin, and calcium-sensing receptor in a myringosclerosis/tympanosclerosis model. ( 24136309 )
2014
21
Morphological alterations in the tympanic membrane affected by tympanosclerosis: ultrastructural study. ( 24134073 )
2014
22
PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media. ( 25399881 )
2014
23
Expressions of TGF-β1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. ( 22777961 )
2012
24
[Assessment of Tumor Necrosis Factor alpha gene expression profile in selected structures of middle ear in patients with tympanosclerosis]. ( 23164102 )
2012
25
Experience with the Vibrant Soundbridge RW-Coupler for round window Vibroplasty with tympanosclerosis. ( 22385350 )
2012
26
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? ( 21888743 )
2011
27
Serum matrix metalloproteinases and tympanosclerosis. ( 20955636 )
2011
28
Is there any relation between coronary atherosclerosis and tympanosclerosis? ( 20382609 )
2010
29
Tympanosclerosis and our surgical results. ( 19771442 )
2010
30
Clinical analysis of intratympanic tympanosclerosis: etiology, ossicular chain findings, and hearing results of surgery. ( 19685361 )
2010
31
Evaluation of the polymorphism in the Toll-like receptor 4 (TLR4) genes of tympanosclerosis patients. ( 19398177 )
2010
32
A computational method for the semi-automated quantitative analysis of tympanic membrane perforations and tympanosclerosis. ( 19643399 )
2009
33
Hearing results of surgery for tympanosclerosis. ( 18704475 )
2009
34
[Expression and localization of macrophages and BMP2 in mucosa of tympanosclerosis]. ( 19670606 )
2009
35
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. ( 18945497 )
2008
36
Analysis of long-term hearing after tympanosclerosis with total/partial stapedectomy and prosthesis used. ( 18607937 )
2008
37
Stapedectomy in tympanosclerosis, hearing results. ( 18454228 )
2008
38
The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosis. ( 18394718 )
2008
39
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. ( 18388770 )
2008
40
Topical application of calcium channel blockers to reduce the progression of experimentally induced myringosclerosis and tympanosclerosis. ( 18176349 )
2008
41
Evaluation of plasma fibronectine level as a probable indicator for tympanosclerosis. ( 17470306 )
2008
42
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. ( 17963670 )
2007
43
Malleostapedotomy in tympanosclerosis patients. ( 17524174 )
2007
44
Tympanosclerosis revisited. ( 23120263 )
2006
45
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. ( 16923708 )
2006
46
Influence of hypercalcemia in the formation of tympanosclerosis in rats. ( 16371843 )
2006
47
Possible relationship between tympanosclerosis and atherosclerosis. ( 15267174 )
2004
48
An analysis of the single-stage tympanoplasty with over-underlay grafting in tympanosclerosis. ( 15129093 )
2004
49
Comparison of free radicals and antioxidant enzymes in chronic otitis media with and without tympanosclerosis. ( 14710000 )
2004
50
Is carotid stenosis correlated with tympanosclerosis. ( 15507892 )
2004

Variations for Tympanosclerosis

Expression for Tympanosclerosis

Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for Tympanosclerosis

Pathways related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.44 BMP2 COL1A1 COL2A1 COL4A1 SPP1
2
Show member pathways
13.02 COL1A1 COL2A1 COL4A1 SPP1
3
Show member pathways
12.66 BMP2 COL1A1 COL2A1 COL4A1 SPP1
4
Show member pathways
12.55 COL1A1 COL2A1 COL4A1 SPP1
5
Show member pathways
12.55 COL1A1 COL2A1 COL4A1 SPP1 TLR4
6
Show member pathways
12.49 COL1A1 COL2A1 COL4A1
7
Show member pathways
12.29 COL1A1 COL2A1 COL4A1
8
Show member pathways
11.76 COL1A1 COL2A1 COL4A1 SPP1 TLR4
9 11.71 COL2A1 COL4A1 TLR4
10
Show member pathways
11.67 BMP2 COL1A1 COL2A1 COL4A1 SPP1
11 11.64 BMP2 COL1A1
12
Show member pathways
11.62 COL1A1 COL4A1
13 11.6 COL1A1 COL4A1
14 11.59 COL1A1 COL4A1 TLR4
15
Show member pathways
11.44 COL1A1 COL2A1 COL4A1 SPP1
16 11.38 COL2A1 SPP1
17 11.37 COL1A1 COL2A1 COL4A1
18 11.26 COL1A1 COL4A1
19 11.19 COL1A1 SPP1
20 11.13 COL1A1 COL4A1
21 11.1 COL1A1 SPP1
22 10.82 BMP2 COL2A1
23 10.46 BMP2 COL1A1 COL2A1 COL4A1 SPP1

GO Terms for Tympanosclerosis

Cellular components related to Tympanosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 BMP2 COL1A1 COL2A1 COL4A1 SPP1
2 extracellular space GO:0005615 9.55 BMP2 COL1A1 COL2A1 COL4A1 SPP1
3 extracellular matrix GO:0031012 9.5 COL1A1 COL2A1 COL4A1
4 collagen-containing extracellular matrix GO:0062023 9.43 COL1A1 COL2A1 COL4A1
5 basement membrane GO:0005604 9.4 COL2A1 COL4A1
6 collagen trimer GO:0005581 9.13 COL1A1 COL2A1 COL4A1
7 endoplasmic reticulum lumen GO:0005788 8.92 COL1A1 COL2A1 COL4A1 SPP1

Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.77 BMP2 COL1A1 SPP1
2 inflammatory response GO:0006954 9.72 BMP2 SPP1 TLR4
3 activation of MAPK activity GO:0000187 9.61 BMP2 TLR4
4 response to bacterium GO:0009617 9.59 BMP2 TLR4
5 cellular response to mechanical stimulus GO:0071260 9.58 COL1A1 TLR4
6 cartilage development GO:0051216 9.58 BMP2 COL2A1
7 skeletal system development GO:0001501 9.58 BMP2 COL1A1 COL2A1
8 cellular response to amino acid stimulus GO:0071230 9.57 COL1A1 COL4A1
9 inner ear development GO:0048839 9.56 BMP2 COL2A1
10 collagen fibril organization GO:0030199 9.54 COL1A1 COL2A1
11 positive regulation of epithelial to mesenchymal transition GO:0010718 9.52 BMP2 COL1A1
12 skeletal system morphogenesis GO:0048705 9.51 COL1A1 COL2A1
13 chondrocyte differentiation GO:0002062 9.49 BMP2 COL2A1
14 cellular response to BMP stimulus GO:0071773 9.48 BMP2 COL2A1
15 response to steroid hormone GO:0048545 9.46 COL1A1 SPP1
16 endochondral ossification GO:0001958 9.43 COL1A1 COL2A1
17 osteoblast differentiation GO:0001649 9.43 BMP2 COL1A1 SPP1
18 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.37 COL1A1 COL4A1
19 ossification GO:0001503 9.33 BMP2 COL1A1 COL2A1
20 proteoglycan metabolic process GO:0006029 9.32 BMP2 COL2A1
21 cartilage development involved in endochondral bone morphogenesis GO:0060351 8.96 COL1A1 COL2A1
22 extracellular matrix organization GO:0030198 8.92 COL1A1 COL2A1 COL4A1 SPP1

Molecular functions related to Tympanosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.33 COL1A1 COL2A1 COL4A1
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL1A1 COL2A1 COL4A1
3 platelet-derived growth factor binding GO:0048407 8.8 COL1A1 COL2A1 COL4A1

Sources for Tympanosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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