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MCID: TYM001
MIFTS: 38

Tympanosclerosis

Categories: Ear diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Tympanosclerosis

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MalaCards integrated aliases for Tympanosclerosis:

Name: Tympanosclerosis 12 15 71 32

Classifications:

MalaCards categories:
Anatomical: Ear diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1214
ICD9CM 34 385.09
ICD10 32 H74.0
UMLS 71 C0155477 C0395887
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Summaries for Tympanosclerosis

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MalaCards based summary : Tympanosclerosis is related to chlamydia pneumonia and chlamydia. An important gene associated with Tympanosclerosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Phospholipase-C Pathway. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone and tongue, and related phenotypes are cellular and cardiovascular system

Wikipedia : 74 Tympanosclerosis is a condition caused by hyalinization and subsequent calcification of subepithelial... more...

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Related Diseases for Tympanosclerosis

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Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 chlamydia pneumonia 30.3 TNF TLR4
2 chlamydia 29.8 TNF TLR4 NOS2
3 deafness, progressive, with stapes fixation 11.3
4 otitis media 10.9
5 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.7
6 cholesteatoma of middle ear 10.7
7 sensorineural hearing loss 10.5
8 suppurative otitis media 10.5
9 chronic purulent otitis media 10.5
10 middle ear disease 10.4
11 otosclerosis 10.3
12 autoimmune myocarditis 10.3 TNF SPP1
13 avascular necrosis 10.3 COL2A1 BMP2
14 kashin-beck disease 10.3 TNF COL2A1
15 dyssegmental dysplasia, silverman-handmaker type 10.3 COL2A1 BMP2
16 atherosclerosis susceptibility 10.3
17 branchiootic syndrome 1 10.3
18 metal allergy 10.2 TNF TLR4
19 x-linked alport syndrome 10.2 COL4A1 COL1A1
20 shwartzman phenomenon 10.2 TNF TLR4
21 superficial basal cell carcinoma 10.2 TNF TLR4
22 pneumonic tularemia 10.2 TNF TLR4
23 streptococcus pneumonia 10.2
24 auditory system disease 10.2
25 pneumonic plague 10.2 TNF TLR4
26 idiopathic neutropenia 10.2 TNF TLR4
27 achondroplasia 10.2 SPP1 COL2A1 COL1A1
28 osteofibrous dysplasia 10.2 SPP1 BMP2
29 epididymis disease 10.2 TNF TLR4
30 taeniasis 10.1 TNF TLR4
31 synovial chondromatosis 10.1 COL2A1 COL1A1 BMP2
32 spondylarthropathy 10.1 TNF TLR4 COL2A1
33 coccidioidomycosis 10.1 TNF TLR4
34 bone development disease 10.1 COL2A1 COL1A1 BMP2
35 urethritis 10.1 TNF TLR4
36 cartilage disease 10.1 TNF COL2A1 BMP2
37 sapho syndrome 10.1 TNF CALCA
38 alcoholic hepatitis 10.1 TNF TLR4 SPP1
39 spotted fever rickettsiosis 10.1 TNF NOS2
40 spinal stenosis 10.1 COL2A1 COL1A1 CALCA
41 carbuncle 10.1 TNF CAT
42 osteonecrosis 10.1 TNF COL2A1 BMP2
43 baritosis 10.0 SPP1 NOS2
44 tendinitis 10.0 TNF SPP1
45 cleft palate, isolated 10.0
46 polykaryocytosis inducer 10.0
47 arterial calcification, generalized, of infancy, 1 10.0
48 hypophosphatemic rickets, x-linked recessive 10.0
49 arterial calcification of infancy 10.0
50 mucositis 10.0

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to Tympanosclerosis
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Symptoms & Phenotypes for Tympanosclerosis

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MGI Mouse Phenotypes related to Tympanosclerosis:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.27 BMP2 CAT COL1A1 COL2A1 COL4A1 NOS2
2 cardiovascular system MP:0005385 10.24 BMP2 COL1A1 COL2A1 COL4A1 NOS2 SOD2
3 homeostasis/metabolism MP:0005376 10.21 BMP2 CAT COL1A1 COL2A1 COL4A1 NOS2
4 growth/size/body region MP:0005378 10.2 BMP2 COL1A1 COL2A1 COL4A1 NOS2 SOD2
5 mortality/aging MP:0010768 10.16 BMP2 CAT COL1A1 COL2A1 COL4A1 NOS2
6 immune system MP:0005387 10.15 BMP2 COL1A1 COL2A1 COL4A1 NOS2 SOD2
7 hematopoietic system MP:0005397 10.13 BMP2 COL1A1 COL4A1 NOS2 SOD2 SPP1
8 adipose tissue MP:0005375 10.07 COL1A1 COL2A1 NOS2 SOD2 TLR4 TNF
9 craniofacial MP:0005382 10.04 BMP2 COL1A1 COL2A1 NOS2 SPP1 TNF
10 digestive/alimentary MP:0005381 10.03 BMP2 COL1A1 COL2A1 NOS2 TLR4 TNF
11 liver/biliary system MP:0005370 10.02 COL1A1 COL2A1 NOS2 SOD2 SPP1 TLR4
12 nervous system MP:0003631 10.02 BMP2 COL1A1 COL2A1 COL4A1 NOS2 SOD2
13 muscle MP:0005369 9.98 COL1A1 COL4A1 NOS2 SOD2 SPP1 TLR4
14 neoplasm MP:0002006 9.95 CAT COL1A1 NOS2 SOD2 SPP1 TLR4
15 hearing/vestibular/ear MP:0005377 9.93 BMP2 COL1A1 COL2A1 SOD2 TLR4
16 renal/urinary system MP:0005367 9.87 COL1A1 COL2A1 COL4A1 NOS2 SOD2 SPP1
17 reproductive system MP:0005389 9.86 BMP2 COL1A1 COL4A1 NOS2 SOD2 SPP1
18 respiratory system MP:0005388 9.7 COL1A1 COL2A1 COL4A1 NOS2 SPP1 TLR4
19 skeleton MP:0005390 9.5 BMP2 COL1A1 COL2A1 NOS2 SPP1 TLR4
20 vision/eye MP:0005391 9.23 COL1A1 COL2A1 COL4A1 NOS2 SOD2 SPP1
Sources

Drugs & Therapeutics for Tympanosclerosis

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Drugs for Tympanosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies
3 Antibodies, Monoclonal

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Withdrawn NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 Suitable Method for Routine Diagnostics of EER in Children With Otitis Media With Effusion Completed NCT02183974
3 Comparison of Three Methods Used in the Diagnosis of Extraesophageal Reflux in Children With Chronic Otitis Media With Effusion Completed NCT02183961

Search NIH Clinical Center for Tympanosclerosis

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Genetic Tests for Tympanosclerosis

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Anatomical Context for Tympanosclerosis

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MalaCards organs/tissues related to Tympanosclerosis:

40
Bone, Tongue
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Publications for Tympanosclerosis

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Articles related to Tympanosclerosis:

(show top 50) (show all 435)
# Title Authors PMID Year
1
Outcomes Following Revision Stapes Surgery in Children: A Single-Surgeon, Single-Center 15-Year Experience. 61
32574481 2020
2
Quantitative assessment of cochlear and vestibular ganglion neurons in temporal bones with chronic otitis media. 61
32488375 2020
3
Microendoscopic Surgery of Middle Ear and Petrous Bone: Benefits Analysis. 61
32511009 2020
4
Use of Mesna in the treatment of ossicular chain fixation related to tympanosclerosis; prospective, clinical study. 61
32451291 2020
5
Factors affecting persistent tympanic membrane perforation after tympanostomy tube removal in children. 61
31786523 2020
6
Körner's septum (petrosquamosal lamina): the anatomical variant or clinical problem? 61
31448811 2020
7
Prevalence of Otitis Media with Effusion in Children with Hearing Loss. 61
31750164 2019
8
Clinical landmarks in chronic otitis media with tympanosclerosis: clinical history may have predictive value in the diagnosis of ossicular chain mobility. 61
31668158 2019
9
The Effect of Nasal Septal Deviation on the Postoperative Hearing Results of Patients With Tympanosclerosis. 61
31578106 2019
10
Outcomes of Primary Pediatric Stapedotomy. 61
31356485 2019
11
[A multi-center retrospective study of ossiculoplasty surgery under oto-endoscope in 45 cases of conductive hearing loss with intact tympanic membrane]. 61
30991774 2019
12
Tophaceous Gout of the Middle Ear: Case Reports and Review of the Literature. 61
31167187 2019
13
Comparison of the Aditus ad Antrum Diameter on CT between Patients with Chronic Otitis Media and Healthy Individuals. 61
32008526 2019
14
[The role of stapedoplasty in the treatment of hearing impairment in the patients presenting with tympanosclerosis]. 61
30938334 2019
15
[Single-stage open tympanoplasty in the form of tympanosclerosis with fixation of the stapes]. 61
31198211 2019
16
[Experiences of second type â…  tympanoplasty]. 61
30716799 2018
17
Metagenomics Analysis of Bacterial Population of Tympanosclerotic Plaques and Cholesteatomas. 61
29688828 2018
18
[The study for the characteristics of secondary acquired cholesteatoma]. 61
30550167 2018
19
Idiopathic, Infectious and Reactive Lesions of the Ear and Temporal Bone. 61
30069844 2018
20
Histopathology of tympanic membranes from patients with ventilation tubes. 61
28774486 2018
21
Different concentrations of mesna application have an effect on the internal ear? 61
29728180 2018
22
[Transcanal endoscopic ear surgery for tympanosclerosis]. 61
29873208 2018
23
Ossicular Chain Reconstruction in a Developing Country. 61
29502435 2018
24
Tympanostomy tubes for serous otitis media and risk of recurrences. 61
29447881 2018
25
Stapes Release in Tympanosclerosis. 61
29210944 2018
26
Minimally invasive laser vibrometry (MIVIB) with a floating mass transducer - A new method for objective evaluation of the middle ear demonstrated on stapes fixation. 61
29190487 2018
27
Use of narrow band imaging and 4K technology in otology and neuro-otology: preliminary experience and feasibility study. 61
29080146 2018
28
Prevalence of chronic ear disease among HIV+ children in Sub-Saharan Africa. 61
29224754 2017
29
Possible role of Dickkopf-1 protein in the pathogenesis of tympanosclerosis in a rat model. 61
28807065 2017
30
The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats. 61
27484331 2017
31
Gene expression profile of collagen types, osteopontin in the tympanic membrane of patients with tympanosclerosis. 61
29068597 2017
32
The role of the nasal and paranasal sinus pathologies on the development of chronic otitis media and its subtypes: A computed tomography study. 61
29072240 2017
33
[Bone conduction in tympanosclerosis patients and its changes after surgery for tympanosclerosis]. 61
29798367 2017
34
The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. 61
28576521 2017
35
Felix tympanoplasty: functional results of a single surgeon's technique in the scope of a literature review on influencing factors. 61
29557559 2017
36
[The prevalence of tympanosclerosis and the effectiveness of its surgical treatment]. 61
28514355 2017
37
[Extragastric symptoms associated with Helicobacter pylori infection]. 61
30299058 2017
38
Pre-operative Indicators of Ossicular Necrosis in Tubotympanic CSOM. 61
27833873 2016
39
Neuroglial Choristoma of the Middle Ear with Massive Tympanosclerosis: A Case Report and Literature Review. 61
27942605 2016
40
Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients. 61
27534583 2016
41
The Efficacy of Adjuvant Intratympanic Steroid Treatment for Otitis Media with Effusion in Children. 61
27413407 2016
42
[Small doses of gentamicin drum indoor injection treatment of intractableMénière disease clinical observation of the impact of the hearing]. 61
29771060 2016
43
Lack of Evidence for Nonotosclerotic Stapes Fixation in Human Temporal Bone Histopathology. 61
26905821 2016
44
Role of Chlamydia pneumoniae and Helicobacteria pylori in the development of tympanosclerosis. 61
25956614 2016
45
Surgical anatomy and pathology of the middle ear. 61
26482007 2016
46
Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis. 61
27959908 2016
47
Tympanosclerosis Presenting as Mass: Workup and Differential. 61
27656306 2016
48
Grommets and speech at three and six years in children born with total cleft or cleft palate. 61
26545794 2015
49
Histological study of the external, middle and inner ear of horses. 61
25283481 2015
50
Surgery of isolated malleus fixation due to tympanosclerosis. 61
25503358 2015
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Variations for Tympanosclerosis

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Expression for Tympanosclerosis

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Search GEO for disease gene expression data for Tympanosclerosis.
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Pathways for Tympanosclerosis

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Pathways related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.57 TNF SPP1 NOS2 COL4A1 COL2A1 COL1A1
2
Phospholipase-C Pathway 63
Show member pathways
 12.84 SPP1 COL4A1 COL2A1 COL1A1 BMP2
3
PI3K-Akt signaling pathway 36
Show member pathways
 12.63 TNF TLR4 SPP1 COL4A1 COL2A1 COL1A1
4
Degradation of the extracellular matrix 65
Show member pathways
 12.46 SPP1 COL4A1 COL2A1 COL1A1 BMP2
5
Tuberculosis 36
12.03 TNF TLR4 NOS2
6
Colorectal Cancer Metastasis 63
11.98 TNF TLR4 NOS2
7
Bacterial infections in CF airways 22
Show member pathways
 11.98 TNF TLR4 NOS2
8
ECM-receptor interaction 36
Show member pathways
 11.86 SPP1 COL4A1 COL2A1 COL1A1
9
AGE-RAGE signaling pathway in diabetic complications 36
11.71 TNF COL4A1 COL1A1
10
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.68 SPP1 COL2A1 BMP2
11
Peroxisome 36
11.61 SOD2 NOS2 CAT
12
Pertussis 36
11.55 TNF TLR4 NOS2
13
Lung fibrosis 1
11.45 TNF SPP1 CALCA
14
Spinal Cord Injury 1
11.43 TNF TLR4 NOS2 COL4A1 COL2A1
15
Cell adhesion_ECM remodeling 22
11.42 COL4A1 COL2A1 COL1A1
16
MSP-RON Signaling 63
11.29 TNF TLR4 NOS2
17
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.11 TNF SPP1 COL1A1 CALCA
18
Amoebiasis 36
11.03 TNF TLR4 NOS2 COL4A1 COL1A1
19
Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway 1
10.9 COL2A1 BMP2
20
Overview of nanoparticle effects 1
10.85 TNF COL4A1
21
G-protein signaling_Rap2B regulation pathway 22
10.64 TNF SPP1 COL4A1 COL2A1 COL1A1 BMP2
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GO Terms for Tympanosclerosis

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Cellular components related to Tympanosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 TNF SPP1 COL4A1 COL2A1 COL1A1 CAT
2 endoplasmic reticulum lumen GO:0005788 9.46 SPP1 COL4A1 COL2A1 COL1A1
3 collagen trimer GO:0005581 9.43 COL4A1 COL2A1 COL1A1
4 phagocytic cup GO:0001891 9.32 TNF TLR4
5 extracellular space GO:0005615 9.23 TNF SPP1 COL4A1 COL2A1 COL1A1 CAT

Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.9 TNF TLR4 RHOXF1 BMP2
2 cellular response to lipopolysaccharide GO:0071222 9.79 TNF TLR4 NOS2
3 response to hypoxia GO:0001666 9.78 NOS2 CAT BMP2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.75 TNF TLR4 CAT
5 skeletal system development GO:0001501 9.74 COL2A1 COL1A1 BMP2
6 response to bacterium GO:0009617 9.72 TLR4 NOS2 BMP2
7 activation of MAPK activity GO:0000187 9.7 TNF TLR4 BMP2
8 negative regulation of osteoclast differentiation GO:0045671 9.61 TLR4 CALCA
9 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.59 TNF TLR4
10 superoxide metabolic process GO:0006801 9.58 SOD2 NOS2
11 positive regulation of chemokine production GO:0032722 9.56 TNF TLR4
12 osteoblast differentiation GO:0001649 9.56 SPP1 COL1A1 CAT BMP2
13 positive regulation of interleukin-8 secretion GO:2000484 9.54 TNF TLR4
14 cellular response to amino acid stimulus GO:0071230 9.54 TNF COL4A1 COL1A1
15 response to hyperoxia GO:0055093 9.51 COL1A1 CAT
16 positive regulation of interleukin-8 production GO:0032757 9.5 TNF TLR4 CALCA
17 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.49 TNF TLR4
18 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.48 TNF TLR4
19 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.46 COL4A1 COL1A1
20 ossification GO:0001503 9.46 SPP1 COL2A1 COL1A1 BMP2
21 proteoglycan metabolic process GO:0006029 9.43 COL2A1 BMP2
22 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.4 COL2A1 COL1A1
23 extracellular matrix organization GO:0030198 9.35 TNF SPP1 COL4A1 COL2A1 COL1A1
24 inflammatory response GO:0006954 9.1 TNF TLR4 SPP1 NOS2 CALCA BMP2

Molecular functions related to Tympanosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 TNF TLR4 SOD2 COL2A1 COL1A1 CAT
2 extracellular matrix structural constituent GO:0005201 9.43 COL4A1 COL2A1 COL1A1
3 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.33 COL4A1 COL2A1 COL1A1
4 platelet-derived growth factor binding GO:0048407 8.8 COL4A1 COL2A1 COL1A1
Sources

Sources for Tympanosclerosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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