MCID: TYP027
MIFTS: 24

Type 1 Diabetes Mellitus 10

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 10

MalaCards integrated aliases for Type 1 Diabetes Mellitus 10:

Name: Type 1 Diabetes Mellitus 10 12 15
Diabetes Mellitus, Insulin-Dependent, 10 74
Insulin-Dependent Diabetes Mellitus 10 12
Iddm10 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110749
ICD10 34 E10
UMLS 74 C1866040

Summaries for Type 1 Diabetes Mellitus 10

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the IL2RA gene on chromosome 10p15.1.

MalaCards based summary : Type 1 Diabetes Mellitus 10, also known as diabetes mellitus, insulin-dependent, 10, is related to diabetes mellitus, insulin-dependent, 10 and congenital aphakia. An important gene associated with Type 1 Diabetes Mellitus 10 is MTPAP (Mitochondrial Poly(A) Polymerase), and among its related pathways/superpathways are Immune response IFN gamma signaling pathway and Rheumatoid arthritis. Related phenotypes are immune system and mortality/aging

Related Diseases for Type 1 Diabetes Mellitus 10

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 10:



Diseases related to Type 1 Diabetes Mellitus 10

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 10

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 10:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.61 APOB CTLA4 CXCL12 FUT2 IL16 IL17A
2 mortality/aging MP:0010768 9.36 APOB CAT CREM CTLA4 CXCL12 HCCS

Drugs & Therapeutics for Type 1 Diabetes Mellitus 10

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 10

Genetic Tests for Type 1 Diabetes Mellitus 10

Anatomical Context for Type 1 Diabetes Mellitus 10

Publications for Type 1 Diabetes Mellitus 10

Articles related to Type 1 Diabetes Mellitus 10:

# Title Authors Year
1
Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. ( 19064853 )
2008

Variations for Type 1 Diabetes Mellitus 10

Expression for Type 1 Diabetes Mellitus 10

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 10.

Pathways for Type 1 Diabetes Mellitus 10

Pathways related to Type 1 Diabetes Mellitus 10 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.27 CXCL12 IL16 IL17A TNFRSF10A
2 10.76 CTLA4 CXCL12 IL17A
3 10.66 CXCL12 IL16 IL17A
4 10.65 CAT SOD2

GO Terms for Type 1 Diabetes Mellitus 10

Cellular components related to Type 1 Diabetes Mellitus 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.17 APOB CAT CXCL12 FUT2 NUDT9 PDCD2

Biological processes related to Type 1 Diabetes Mellitus 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.33 CAT CXCL12 HMOX2
2 response to radiation GO:0009314 9.26 CAT CXCL12
3 regulation of calcium ion transport GO:0051924 8.96 CXCL12 IL16
4 induction of positive chemotaxis GO:0050930 8.62 CXCL12 IL16

Sources for Type 1 Diabetes Mellitus 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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