MCID: TYP035
MIFTS: 23

Type 1 Diabetes Mellitus 11

Categories: Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 11

MalaCards integrated aliases for Type 1 Diabetes Mellitus 11:

Name: Type 1 Diabetes Mellitus 11 12 15
Diabetes Mellitus, Insulin-Dependent, 11 71
Insulin-Dependent Diabetes Mellitus 11 12
Iddm11 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110750
ICD10 32 E10
UMLS 71 C1832605

Summaries for Type 1 Diabetes Mellitus 11

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 14q24.3-q31.

MalaCards based summary : Type 1 Diabetes Mellitus 11, also known as diabetes mellitus, insulin-dependent, 11, is related to diabetes mellitus, type i and diabetes mellitus. An important gene associated with Type 1 Diabetes Mellitus 11 is SEL1L (SEL1L Adaptor Subunit Of ERAD E3 Ubiquitin Ligase), and among its related pathways/superpathways are Developmental Biology and Glucose / Energy Metabolism. Related phenotype is Decreased viability with paclitaxel.

Related Diseases for Type 1 Diabetes Mellitus 11

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Type I Diabetes Mellitus, Congenital Autoimmune
Type 1 Diabetes Mellitus 2 Type 1 Diabetes Mellitus 3
Type 1 Diabetes Mellitus 4 Type 1 Diabetes Mellitus 5
Type 1 Diabetes Mellitus 6 Type 1 Diabetes Mellitus 7
Type 1 Diabetes Mellitus 8 Type 1 Diabetes Mellitus 10
Type 1 Diabetes Mellitus 11 Type 1 Diabetes Mellitus 12
Type 1 Diabetes Mellitus 13 Type 1 Diabetes Mellitus 15
Type 1 Diabetes Mellitus 17 Type 1 Diabetes Mellitus 18
Rare Diabetes Mellitus Type 1 Rare Diabetes Mellitus Type 2
Rare Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus 11 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, type i 30.9 SEL1L PDX1 NEUROD1 HNF1A
2 diabetes mellitus 30.5 PDX1 NEUROD1 HNF1A CELA2A
3 diabetes mellitus, insulin-dependent, 11 12.2
4 rare diabetes mellitus type 2 9.7 NEUROD1 HNF1A
5 monogenic diabetes 9.6 PDX1 HNF1A
6 maturity-onset diabetes of the young, type 11 9.6 PDX1 NEUROD1
7 maturity-onset diabetes of the young, type 14 9.6 PDX1 NEUROD1
8 maturity-onset diabetes of the young, type 10 9.6 PDX1 NEUROD1
9 maturity-onset diabetes of the young, type 7 9.5 PDX1 NEUROD1
10 maturity-onset diabetes of the young, type 9 9.5 PDX1 NEUROD1
11 diabetes mellitus, permanent neonatal 4 9.5 PDX1 NEUROD1
12 hyperinsulinemic hypoglycemia 9.5 SEL1L PDX1 HNF1A
13 pancreatic agenesis 9.4 PDX1 NEUROD1
14 maturity-onset diabetes of the young 9.3 PDX1 NEUROD1 HNF1A
15 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 9.3 PDX1 NEUROD1 HNF1A
16 pancreatic cystadenoma 9.3 PDX1 NEUROD1
17 maturity-onset diabetes of the young, type 1 9.3 PDX1 NEUROD1 HNF1A
18 maturity-onset diabetes of the young, type 13 9.3 PDX1 NEUROD1 HNF1A
19 maturity-onset diabetes of the young, type 6 9.3 PDX1 NEUROD1 HNF1A
20 maturity-onset diabetes of the young, type 4 9.3 PDX1 NEUROD1 HNF1A
21 maturity-onset diabetes of the young, type 2 9.3 PDX1 NEUROD1 HNF1A
22 renal cysts and diabetes syndrome 9.3 PDX1 NEUROD1 HNF1A
23 maturity-onset diabetes of the young, type 3 9.3 PDX1 NEUROD1 HNF1A
24 neonatal diabetes mellitus 9.3 PDX1 NEUROD1 HNF1A
25 insulinoma 9.2 PDX1 NEUROD1 HNF1A
26 transient neonatal diabetes mellitus 9.2 PDX1 NEUROD1

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 11:



Diseases related to Type 1 Diabetes Mellitus 11

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 11

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00054-A 8.8 NEUROD1 PDX1 PSMC3

Drugs & Therapeutics for Type 1 Diabetes Mellitus 11

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 11

Genetic Tests for Type 1 Diabetes Mellitus 11

Anatomical Context for Type 1 Diabetes Mellitus 11

Publications for Type 1 Diabetes Mellitus 11

Articles related to Type 1 Diabetes Mellitus 11:

# Title Authors PMID Year
1
Clinical spectrum of voltage-gated potassium channel autoimmunity. 61
18474843 2008
2
Improved glycemic control and platelet function abnormalities in diabetic patients with microvascular disease. 61
10647069 2000
3
Plasma endothelin-1 levels in patients with diabetes mellitus with or without vascular complication. 61
1725417 1991
4
Angiotensin converting enzyme inhibitor therapy to decrease microalbuminuria in normotensive children with insulin-dependent diabetes mellitus. 61
2196359 1990

Variations for Type 1 Diabetes Mellitus 11

Expression for Type 1 Diabetes Mellitus 11

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 11.

Pathways for Type 1 Diabetes Mellitus 11

GO Terms for Type 1 Diabetes Mellitus 11

Biological processes related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.78 PSMC3 PDX1 NEUROD1 HNF1A
2 glucose homeostasis GO:0042593 9.54 PDX1 NEUROD1 HNF1A
3 liver development GO:0001889 9.49 PDX1 HNF1A
4 pancreas development GO:0031016 9.46 PDX1 HNF1A
5 blastocyst development GO:0001824 9.43 PSMC3 HNF1A
6 regulation of insulin secretion GO:0050796 9.43 NEUROD1 ENSA CELA2A
7 nitric oxide mediated signal transduction GO:0007263 9.4 PDX1 NEUROD1
8 insulin secretion GO:0030073 9.33 PDX1 NEUROD1 HNF1A
9 negative regulation of type B pancreatic cell apoptotic process GO:2000675 9.32 PDX1 NEUROD1
10 endocrine pancreas development GO:0031018 9.13 PDX1 NEUROD1 HNF1A
11 response to glucose GO:0009749 8.92 PDX1 NEUROD1 HNF1A ENSA

Molecular functions related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.13 PDX1 NEUROD1 HNF1A
2 transcription factor binding GO:0008134 8.8 PDX1 NEUROD1 HNF1A

Sources for Type 1 Diabetes Mellitus 11

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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