MCID: TYP035
MIFTS: 28

Type 1 Diabetes Mellitus 11

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 11

MalaCards integrated aliases for Type 1 Diabetes Mellitus 11:

Name: Type 1 Diabetes Mellitus 11 12 15
Diabetes Mellitus, Insulin-Dependent, 11 74
Insulin-Dependent Diabetes Mellitus 11 12
Iddm11 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110750
ICD10 34 E10
UMLS 74 C1832605

Summaries for Type 1 Diabetes Mellitus 11

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 14q24.3-q31.

MalaCards based summary : Type 1 Diabetes Mellitus 11, also known as diabetes mellitus, insulin-dependent, 11, is related to diabetes mellitus, insulin-dependent and diabetes mellitus, insulin-dependent, 11. An important gene associated with Type 1 Diabetes Mellitus 11 is SEL1L (SEL1L Adaptor Subunit Of ERAD E3 Ubiquitin Ligase), and among its related pathways/superpathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Cardiac Progenitor Differentiation. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Type 1 Diabetes Mellitus 11

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 11 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent 31.1 CTLA4 HNF1A INS
2 diabetes mellitus, insulin-dependent, 11 11.8
3 perrault syndrome 1 11.1
4 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.2 HBA1 HBA2
5 methemoglobinemia, beta-globin type 10.2 HBA1 HBA2
6 diabetes mellitus, insulin-dependent, 24 10.2 HBA1 HBA2
7 hydrops fetalis, nonimmune 10.2 HBA1 HBA2
8 hydrops fetalis 10.2 HBA1 HBA2
9 glutathione peroxidase deficiency 10.2 HBA1 HBA2
10 heinz body anemias 10.2 HBA1 HBA2
11 erythrocytosis, familial, 7 10.2 HBA1 HBA2
12 immature cataract 10.2 HBA1 HBA2
13 diabetes mellitus 10.2
14 alpha thalassemia-intellectual disability syndrome type 1 10.1 HBA1 HBA2
15 type 1 diabetes mellitus 17 10.0 CTLA4 TNFRSF25
16 hemangioma of intra-abdominal structure 10.0 CTLA4 HBA1
17 hemoglobin h disease 10.0 HBA1 HBA2
18 maturity-onset diabetes of the young, type 2 10.0 HNF1A INS
19 maturity-onset diabetes of the young, type 3 9.9 HNF1A INS
20 maturity-onset diabetes of the young, type 13 9.9 HNF1A INS
21 background diabetic retinopathy 9.9 HBA2 INS
22 autoimmune disease of gastrointestinal tract 9.9 CTLA4 TNFRSF25
23 hemoglobinopathy 9.9 HBA1 HBA2
24 diabetic autonomic neuropathy 9.9 HBA2 INS
25 autonomic nervous system disease 9.9 HBA2 INS
26 type 1 diabetes mellitus 2 9.9 INS TNFRSF25
27 rubeosis iridis 9.9 HBA2 INS
28 maturity-onset diabetes of the young, type 6 9.9 HNF1A INS
29 monogenic diabetes 9.9 HNF1A INS
30 maturity-onset diabetes of the young, type 7 9.8 HNF1A INS
31 type 1 diabetes mellitus 12 9.8 CTLA4 INS
32 microcytic anemia 9.8 HBA1 HBA2
33 type 1 diabetes mellitus 13 9.8 CTLA4 INS
34 chorioangioma 9.8 CTLA4 HBA1 NOTCH1
35 hypoglycemic coma 9.8 HBA1 HBA2 INS
36 type 1 diabetes mellitus 7 9.8 HBA1 HBA2 INS
37 retinal vascular disease 9.8 HBA1 HBA2 INS
38 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8 CTLA4 INS
39 autoimmune disease of endocrine system 9.6 CTLA4 INS TNFRSF25
40 glucose metabolism disease 9.5 HBA1 HBA2 INS TNFRSF25
41 large intestine cancer 9.5 HBA1 INS NOTCH1
42 type 1 diabetes mellitus 5 9.4 CTLA4 HBA2 INS TNFRSF25

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 11:



Diseases related to Type 1 Diabetes Mellitus 11

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 11

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

27 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.77 HNF1A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.77 HNF1A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.77 HBA1 HBA2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.77 HNF1A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.77 HNF1A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.77 HNF1A
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.77 HNF1A
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.77 HBA1 HBA2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.77 HBA1 HBA2 HNF1A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.55 HBA1 HBA2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.55 HBA1 HBA2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.55 NOTCH1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.55 NOTCH1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.55 HBA1 HBA2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.55 NOTCH1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.55 NOTCH1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.55 HBA1 HBA2 NOTCH1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.55 NOTCH1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.55 NOTCH1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.55 NOTCH1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.55 NOTCH1

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 11:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.73 CTLA4 HNF1A INS NOTCH1 SEL1L TNFRSF25
2 digestive/alimentary MP:0005381 9.72 CTLA4 HNF1A INS NOTCH1 SEL1L
3 liver/biliary system MP:0005370 9.63 CTLA4 FN1 HNF1A INS NOTCH1 SEL1L
4 mortality/aging MP:0010768 9.56 CTLA4 FN1 HBA2 HNF1A INS NOTCH1
5 skeleton MP:0005390 9.1 CTLA4 FN1 HNF1A INS NOTCH1 SEL1L

Drugs & Therapeutics for Type 1 Diabetes Mellitus 11

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 11

Genetic Tests for Type 1 Diabetes Mellitus 11

Anatomical Context for Type 1 Diabetes Mellitus 11

Publications for Type 1 Diabetes Mellitus 11

Variations for Type 1 Diabetes Mellitus 11

Expression for Type 1 Diabetes Mellitus 11

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 11.

Pathways for Type 1 Diabetes Mellitus 11

GO Terms for Type 1 Diabetes Mellitus 11

Cellular components related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 FN1 HBA1 HBA2 INS NOTCH1 TNFRSF25
2 blood microparticle GO:0072562 9.43 FN1 HBA1 HBA2
3 cytosolic small ribosomal subunit GO:0022627 9.37 HBA1 HBA2
4 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
5 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
6 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 embryonic limb morphogenesis GO:0030326 9.4 HNF1A NOTCH1
2 response to hydrogen peroxide GO:0042542 9.37 HBA1 HBA2
3 positive regulation of cell death GO:0010942 9.32 HBA1 HBA2
4 bicarbonate transport GO:0015701 9.26 HBA1 HBA2
5 acute-phase response GO:0006953 9.16 FN1 INS
6 hydrogen peroxide catabolic process GO:0042744 8.96 HBA1 HBA2
7 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.32 HBA1 HBA2
2 peroxidase activity GO:0004601 9.26 HBA1 HBA2
3 oxygen carrier activity GO:0005344 9.16 HBA1 HBA2
4 organic acid binding GO:0043177 8.96 HBA1 HBA2
5 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Type 1 Diabetes Mellitus 11

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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