MCID: TYP035
MIFTS: 29

Type 1 Diabetes Mellitus 11

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 11

MalaCards integrated aliases for Type 1 Diabetes Mellitus 11:

Name: Type 1 Diabetes Mellitus 11 12 15
Diabetes Mellitus, Insulin-Dependent, 11 73
Insulin-Dependent Diabetes Mellitus 11 12
Iddm11 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110750
ICD10 33 E10
UMLS 73 C1832605

Summaries for Type 1 Diabetes Mellitus 11

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 14q24.3-q31.

MalaCards based summary : Type 1 Diabetes Mellitus 11, also known as diabetes mellitus, insulin-dependent, 11, is related to diabetes mellitus, insulin-dependent and diabetes mellitus, insulin-dependent, 11. An important gene associated with Type 1 Diabetes Mellitus 11 is SEL1L (SEL1L, ERAD E3 Ligase Adaptor Subunit), and among its related pathways/superpathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Cardiac Progenitor Differentiation. Affiliated tissues include t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Type 1 Diabetes Mellitus 11

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 11 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent 31.1 CTLA4 HNF1A INS SEL1L TNFRSF25
2 diabetes mellitus, insulin-dependent, 11 11.8
3 perrault syndrome 1 11.1
4 diabetes mellitus 10.1
5 maturity-onset diabetes of the young, type 2 10.1 HNF1A INS
6 maturity-onset diabetes of the young, type 3 10.1 HNF1A INS
7 maturity-onset diabetes of the young, type 13 10.1 HNF1A INS
8 background diabetic retinopathy 10.1 HBA2 INS
9 type 1 diabetes mellitus 17 10.1 CTLA4 TNFRSF25
10 type 1 diabetes mellitus 2 10.1 INS TNFRSF25
11 diabetic autonomic neuropathy 10.1 HBA2 INS
12 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.1 HBA1 HBA2
13 methemoglobinemia, beta-globin type 10.1 HBA1 HBA2
14 diabetes mellitus, insulin-dependent, 24 10.1 HBA1 HBA2
15 hydrops fetalis, nonimmune 10.1 HBA1 HBA2
16 autonomic nervous system disease 10.1 HBA2 INS
17 hydrops fetalis 10.1 HBA1 HBA2
18 glutathione peroxidase deficiency 10.1 HBA1 HBA2
19 immune hydrops fetalis 10.0 HBA1 HBA2
20 maturity-onset diabetes of the young, type 6 10.0 HNF1A INS
21 type 1 diabetes mellitus 12 10.0 CTLA4 INS
22 rubeosis iridis 10.0 HBA2 INS
23 heinz body anemias 10.0 HBA1 HBA2
24 erythrocytosis, familial, 7 10.0 HBA1 HBA2
25 immature cataract 10.0 HBA1 HBA2
26 type 1 diabetes mellitus 13 10.0 CTLA4 INS
27 monogenic diabetes 10.0 HNF1A INS
28 autoimmune disease of gastrointestinal tract 10.0 CTLA4 TNFRSF25
29 maturity-onset diabetes of the young, type 7 10.0 HNF1A INS
30 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 CTLA4 INS
31 alpha thalassemia-intellectual disability syndrome type 1 10.0 HBA1 HBA2
32 hemangioma of intra-abdominal structure 10.0 CTLA4 HBA1
33 hemoglobin h disease 9.9 HBA1 HBA2
34 hemoglobinopathy 9.9 HBA1 HBA2
35 autoimmune disease of endocrine system 9.9 CTLA4 INS TNFRSF25
36 hypoglycemic coma 9.9 HBA1 HBA2 INS
37 microcytic anemia 9.9 HBA1 HBA2
38 type 1 diabetes mellitus 7 9.9 HBA1 HBA2 INS
39 retinal vascular disease 9.9 HBA1 HBA2 INS
40 sickle cell anemia 9.8 HBA1 HBA2
41 type 1 diabetes mellitus 5 9.7 CTLA4 HBA2 INS TNFRSF25
42 chorioangioma 9.7 CTLA4 HBA1 NOTCH1
43 glucose metabolism disease 9.7 HBA1 HBA2 INS TNFRSF25
44 large intestine cancer 9.6 HBA1 INS NOTCH1

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 11:



Diseases related to Type 1 Diabetes Mellitus 11

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 11

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.8 HNF1A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.8 HNF1A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.8 HBA1 HBA2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.8 HNF1A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.8 HNF1A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.8 HNF1A
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.8 HNF1A
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.8 HBA1 HBA2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.8 HBA1 HBA2 HNF1A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.8 HNF1A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 HBA1 HBA2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.53 HBA1 HBA2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.53 NOTCH1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.53 NOTCH1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.53 HBA1 HBA2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.53 NOTCH1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.53 NOTCH1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.53 HBA1 HBA2 NOTCH1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.53 NOTCH1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.53 NOTCH1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.53 NOTCH1

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 11:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.55 CTLA4 HNF1A INS NOTCH1 SEL1L
2 endocrine/exocrine gland MP:0005379 9.43 CTLA4 HNF1A INS NOTCH1 SEL1L TNFRSF25
3 liver/biliary system MP:0005370 9.02 CTLA4 HNF1A INS NOTCH1 SEL1L

Drugs & Therapeutics for Type 1 Diabetes Mellitus 11

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 11

Genetic Tests for Type 1 Diabetes Mellitus 11

Anatomical Context for Type 1 Diabetes Mellitus 11

MalaCards organs/tissues related to Type 1 Diabetes Mellitus 11:

41
T Cells

Publications for Type 1 Diabetes Mellitus 11

Variations for Type 1 Diabetes Mellitus 11

Expression for Type 1 Diabetes Mellitus 11

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 11.

Pathways for Type 1 Diabetes Mellitus 11

GO Terms for Type 1 Diabetes Mellitus 11

Cellular components related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosolic small ribosomal subunit GO:0022627 9.26 HBA1 HBA2
2 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
3 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
4 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of insulin secretion GO:0050796 9.43 ENSA HNF1A
2 negative regulation of catalytic activity GO:0043086 9.4 ENSA NOTCH1
3 embryonic limb morphogenesis GO:0030326 9.37 HNF1A NOTCH1
4 response to hydrogen peroxide GO:0042542 9.32 HBA1 HBA2
5 positive regulation of cell death GO:0010942 9.26 HBA1 HBA2
6 bicarbonate transport GO:0015701 9.16 HBA1 HBA2
7 hydrogen peroxide catabolic process GO:0042744 8.96 HBA1 HBA2
8 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.32 HBA1 HBA2
2 peroxidase activity GO:0004601 9.26 HBA1 HBA2
3 oxygen carrier activity GO:0005344 9.16 HBA1 HBA2
4 organic acid binding GO:0043177 8.96 HBA1 HBA2
5 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Type 1 Diabetes Mellitus 11

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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