MCID: TYP035
MIFTS: 28

Type 1 Diabetes Mellitus 11

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 11

MalaCards integrated aliases for Type 1 Diabetes Mellitus 11:

Name: Type 1 Diabetes Mellitus 11 12 15
Diabetes Mellitus, Insulin-Dependent, 11 72
Insulin-Dependent Diabetes Mellitus 11 12
Iddm11 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110750
ICD10 33 E10
UMLS 72 C1832605

Summaries for Type 1 Diabetes Mellitus 11

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 14q24.3-q31.

MalaCards based summary : Type 1 Diabetes Mellitus 11, also known as diabetes mellitus, insulin-dependent, 11, is related to diabetes mellitus, insulin-dependent and diabetes mellitus, insulin-dependent, 11. An important gene associated with Type 1 Diabetes Mellitus 11 is SEL1L (SEL1L Adaptor Subunit Of ERAD E3 Ubiquitin Ligase), and among its related pathways/superpathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Cardiac Progenitor Differentiation. Related phenotypes are endocrine/exocrine gland and digestive/alimentary

Related Diseases for Type 1 Diabetes Mellitus 11

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18 Rare Diabetes Mellitus Type 1
Rare Diabetes Mellitus Type 2 Rare Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus 11 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent 31.6 INS HNF1A CTLA4
2 diabetes mellitus, insulin-dependent, 11 12.2
3 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.4 HBA2 HBA1
4 methemoglobinemia, beta-globin type 10.4 HBA2 HBA1
5 diabetes mellitus, insulin-dependent, 24 10.4 HBA2 HBA1
6 hydrops fetalis, nonimmune 10.4 HBA2 HBA1
7 hydrops fetalis 10.4 HBA2 HBA1
8 glutathione peroxidase deficiency 10.3 HBA2 HBA1
9 erythrocytosis, familial, 7 10.3 HBA2 HBA1
10 heinz body anemias 10.3 HBA2 HBA1
11 immature cataract 10.3 HBA2 HBA1
12 alpha thalassemia-intellectual disability syndrome type 1 10.1 HBA2 HBA1
13 type 1 diabetes mellitus 17 10.1 TNFRSF25 CTLA4
14 hemangioma of intra-abdominal structure 10.0 HBA1 CTLA4
15 hemoglobin h disease 10.0 HBA2 HBA1
16 maturity-onset diabetes of the young, type 2 10.0 INS HNF1A
17 autoimmune disease of gastrointestinal tract 9.9 TNFRSF25 CTLA4
18 maturity-onset diabetes of the young, type 3 9.9 INS HNF1A
19 hemoglobinopathy 9.9 HBA2 HBA1
20 maturity-onset diabetes of the young, type 13 9.9 INS HNF1A
21 background diabetic retinopathy 9.9 INS HBA2
22 type 1 diabetes mellitus 2 9.9 TNFRSF25 INS
23 diabetic autonomic neuropathy 9.9 INS HBA2
24 autonomic nervous system disease 9.8 INS HBA2
25 maturity-onset diabetes of the young, type 6 9.8 INS HNF1A
26 rubeosis iridis 9.8 INS HBA2
27 monogenic diabetes 9.8 INS HNF1A
28 maturity-onset diabetes of the young, type 7 9.7 INS HNF1A
29 type 1 diabetes mellitus 12 9.7 INS CTLA4
30 microcytic anemia 9.7 HBA2 HBA1
31 chorioangioma 9.7 NOTCH1 HBA1 CTLA4
32 type 1 diabetes mellitus 13 9.7 INS CTLA4
33 hypoglycemic coma 9.6 INS HBA2 HBA1
34 type 1 diabetes mellitus 7 9.6 INS HBA2 HBA1
35 retinal vascular disease 9.6 INS HBA2 HBA1
36 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.6 INS CTLA4
37 autoimmune disease of endocrine system 9.3 TNFRSF25 INS CTLA4
38 glucose metabolism disease 9.2 TNFRSF25 INS HBA2 HBA1
39 large intestine cancer 9.2 NOTCH1 INS HBA1
40 type 1 diabetes mellitus 5 9.0 TNFRSF25 INS HBA2 CTLA4

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 11:



Diseases related to Type 1 Diabetes Mellitus 11

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 11

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 11:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.73 CTLA4 HNF1A INS NOTCH1 SEL1L TNFRSF25
2 digestive/alimentary MP:0005381 9.72 CTLA4 HNF1A INS NOTCH1 SEL1L
3 liver/biliary system MP:0005370 9.63 CTLA4 FN1 HNF1A INS NOTCH1 SEL1L
4 mortality/aging MP:0010768 9.56 CTLA4 FN1 HBA2 HNF1A INS NOTCH1
5 skeleton MP:0005390 9.1 CTLA4 FN1 HNF1A INS NOTCH1 SEL1L

Drugs & Therapeutics for Type 1 Diabetes Mellitus 11

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 11

Genetic Tests for Type 1 Diabetes Mellitus 11

Anatomical Context for Type 1 Diabetes Mellitus 11

Publications for Type 1 Diabetes Mellitus 11

Articles related to Type 1 Diabetes Mellitus 11:

# Title Authors PMID Year
1
Clinical spectrum of voltage-gated potassium channel autoimmunity. 38
18474843 2008
2
Improved glycemic control and platelet function abnormalities in diabetic patients with microvascular disease. 38
10647069 2000
3
Plasma endothelin-1 levels in patients with diabetes mellitus with or without vascular complication. 38
1725417 1991
4
Angiotensin converting enzyme inhibitor therapy to decrease microalbuminuria in normotensive children with insulin-dependent diabetes mellitus. 38
2196359 1990

Variations for Type 1 Diabetes Mellitus 11

Expression for Type 1 Diabetes Mellitus 11

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 11.

Pathways for Type 1 Diabetes Mellitus 11

GO Terms for Type 1 Diabetes Mellitus 11

Cellular components related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNFRSF25 NOTCH1 INS HBA2 HBA1 FN1
2 blood microparticle GO:0072562 9.43 HBA2 HBA1 FN1
3 cytosolic small ribosomal subunit GO:0022627 9.37 HBA2 HBA1
4 endocytic vesicle lumen GO:0071682 9.16 HBA2 HBA1
5 hemoglobin complex GO:0005833 8.96 HBA2 HBA1
6 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA2 HBA1

Biological processes related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 embryonic limb morphogenesis GO:0030326 9.4 NOTCH1 HNF1A
2 response to hydrogen peroxide GO:0042542 9.37 HBA2 HBA1
3 positive regulation of cell death GO:0010942 9.32 HBA2 HBA1
4 bicarbonate transport GO:0015701 9.26 HBA2 HBA1
5 acute-phase response GO:0006953 9.16 INS FN1
6 hydrogen peroxide catabolic process GO:0042744 8.96 HBA2 HBA1
7 oxygen transport GO:0015671 8.62 HBA2 HBA1

Molecular functions related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.32 HBA2 HBA1
2 peroxidase activity GO:0004601 9.26 HBA2 HBA1
3 oxygen carrier activity GO:0005344 9.16 HBA2 HBA1
4 organic acid binding GO:0043177 8.96 HBA2 HBA1
5 haptoglobin binding GO:0031720 8.62 HBA2 HBA1

Sources for Type 1 Diabetes Mellitus 11

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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