MCID: TYP035
MIFTS: 22

Type 1 Diabetes Mellitus 11

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 11

MalaCards integrated aliases for Type 1 Diabetes Mellitus 11:

Name: Type 1 Diabetes Mellitus 11 12 15
Diabetes Mellitus, Insulin-Dependent, 11 71
Insulin-Dependent Diabetes Mellitus 11 12
Iddm11 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110750
ICD10 32 E10
UMLS 71 C1832605

Summaries for Type 1 Diabetes Mellitus 11

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 14q24.3-q31.

MalaCards based summary : Type 1 Diabetes Mellitus 11, also known as diabetes mellitus, insulin-dependent, 11, is related to diabetes mellitus, insulin-dependent and diabetes mellitus, insulin-dependent, 11. An important gene associated with Type 1 Diabetes Mellitus 11 is SEL1L (SEL1L Adaptor Subunit Of ERAD E3 Ubiquitin Ligase), and among its related pathways/superpathways are Regulation of beta-cell development and Type II diabetes mellitus. Related phenotype is Decreased viability with paclitaxel.

Related Diseases for Type 1 Diabetes Mellitus 11

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18 Rare Diabetes Mellitus Type 1
Rare Diabetes Mellitus Type 2 Rare Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus 11 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent 31.3 SEL1L PDX1 NEUROD1
2 diabetes mellitus, insulin-dependent, 11 12.2
3 diabetes mellitus 11.4
4 type 1 diabetes mellitus 15 10.0 ZFAT-AS1 PSMC3
5 maturity-onset diabetes of the young, type 1 9.7 PDX1 NEUROD1
6 maturity-onset diabetes of the young, type 11 9.7 PDX1 NEUROD1
7 maturity-onset diabetes of the young, type 13 9.7 PDX1 NEUROD1
8 maturity-onset diabetes of the young, type 10 9.7 PDX1 NEUROD1
9 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 9.7 PDX1 NEUROD1
10 maturity-onset diabetes of the young, type 7 9.7 PDX1 NEUROD1
11 maturity-onset diabetes of the young, type 9 9.7 PDX1 NEUROD1
12 maturity-onset diabetes of the young, type 6 9.7 PDX1 NEUROD1
13 maturity-onset diabetes of the young, type 4 9.7 PDX1 NEUROD1
14 maturity-onset diabetes of the young, type 2 9.6 PDX1 NEUROD1
15 renal cysts and diabetes syndrome 9.6 PDX1 NEUROD1
16 maturity-onset diabetes of the young, type 3 9.6 PDX1 NEUROD1
17 pancreatic cystadenoma 9.6 PDX1 NEUROD1
18 pancreatic agenesis 9.6 PDX1 NEUROD1
19 transient neonatal diabetes mellitus 9.5 PDX1 NEUROD1
20 neonatal diabetes mellitus 9.4 PDX1 NEUROD1
21 diabetes mellitus, permanent neonatal 9.2 PDX1 NEUROD1

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 11:



Diseases related to Type 1 Diabetes Mellitus 11

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 11

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00054-A 8.8 NEUROD1 PDX1 PSMC3

Drugs & Therapeutics for Type 1 Diabetes Mellitus 11

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 11

Genetic Tests for Type 1 Diabetes Mellitus 11

Anatomical Context for Type 1 Diabetes Mellitus 11

Publications for Type 1 Diabetes Mellitus 11

Articles related to Type 1 Diabetes Mellitus 11:

# Title Authors PMID Year
1
Clinical spectrum of voltage-gated potassium channel autoimmunity. 61
18474843 2008
2
Improved glycemic control and platelet function abnormalities in diabetic patients with microvascular disease. 61
10647069 2000
3
Plasma endothelin-1 levels in patients with diabetes mellitus with or without vascular complication. 61
1725417 1991
4
Angiotensin converting enzyme inhibitor therapy to decrease microalbuminuria in normotensive children with insulin-dependent diabetes mellitus. 61
2196359 1990

Variations for Type 1 Diabetes Mellitus 11

Expression for Type 1 Diabetes Mellitus 11

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 11.

Pathways for Type 1 Diabetes Mellitus 11

GO Terms for Type 1 Diabetes Mellitus 11

Biological processes related to Type 1 Diabetes Mellitus 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.71 ZFAT PSMC3 PDX1 NEUROD1
2 regulation of insulin secretion GO:0050796 9.37 NEUROD1 ENSA
3 insulin secretion GO:0030073 9.32 PDX1 NEUROD1
4 endocrine pancreas development GO:0031018 9.26 PDX1 NEUROD1
5 nitric oxide mediated signal transduction GO:0007263 9.16 PDX1 NEUROD1
6 negative regulation of type B pancreatic cell apoptotic process GO:2000675 8.96 PDX1 NEUROD1
7 response to glucose GO:0009749 8.8 PDX1 NEUROD1 ENSA

Sources for Type 1 Diabetes Mellitus 11

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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