MCID: TYP036
MIFTS: 21

Type 1 Diabetes Mellitus 12

Categories: Metabolic diseases, Endocrine diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 12

MalaCards integrated aliases for Type 1 Diabetes Mellitus 12:

Name: Type 1 Diabetes Mellitus 12 12 15
Diabetes Mellitus, Insulin-Dependent, 12 73
Insulin-Dependent Diabetes Mellitus 12 12
Iddm12 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110751
ICD10 33 E10
UMLS 73 C1832392

Summaries for Type 1 Diabetes Mellitus 12

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the CTLA4 gene on chromosome 2q33.2.

MalaCards based summary : Type 1 Diabetes Mellitus 12, also known as diabetes mellitus, insulin-dependent, 12, is related to graves' disease and diabetes mellitus, insulin-dependent, 12. An important gene associated with Type 1 Diabetes Mellitus 12 is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Allograft rejection.

Related Diseases for Type 1 Diabetes Mellitus 12

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 12 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 graves' disease 28.9 CTLA4 HLA-DRB1
2 diabetes mellitus, insulin-dependent, 12 11.1
3 autoimmune addison disease 10.1 CTLA4 HLA-DRB1
4 autoimmune pancreatitis 10.1 CTLA4 HLA-DRB1
5 anca-associated vasculitis 10.1 CTLA4 HLA-DRB1
6 pemphigus foliaceus 10.1 CTLA4 HLA-DRB1
7 sympathetic ophthalmia 10.1 CTLA4 HLA-DRB1
8 severe hemophilia a 10.0 CTLA4 HLA-DRB1
9 rheumatoid factor-negative juvenile idiopathic arthritis 10.0 HLA-DRB1 SLC11A1
10 hypersensitivity reaction disease 10.0 CTLA4 HLA-DRB1
11 autoimmune hepatitis 10.0 CTLA4 HLA-DRB1
12 nontuberculous mycobacterial lung disease 9.9 HLA-DRB1 SLC11A1
13 hypothyroidism 9.9
14 thyroiditis 9.9
15 type 1 diabetes mellitus 11 9.9 CTLA4 INS
16 juvenile rheumatoid arthritis 9.8 HLA-DRB1 SLC11A1
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8 CTLA4 INS
18 pulmonary tuberculosis 9.8 HLA-DRB1 SLC11A1
19 type 1 diabetes mellitus 7 9.7 INS SLC11A1
20 hyperthyroidism 9.7 CTLA4 INS
21 sarcoidosis 1 9.7 HLA-DRB1 SLC11A1
22 leishmaniasis 9.6 HLA-DRB1 SLC11A1
23 type 1 diabetes mellitus 2 9.4 CTLA4 FGF3 INS
24 type 1 diabetes mellitus 13 9.3 CTLA4 INS SLC11A1
25 rheumatoid arthritis 9.2 CTLA4 HLA-DRB1 SLC11A1
26 autoimmune disease 9.1 CTLA4 HLA-DRB1 INS
27 inflammatory bowel disease 9.0 CTLA4 HLA-DRB1 SLC11A1
28 type 1 diabetes mellitus 5 8.8 CTLA4 FGF3 INS SUMO4
29 diabetes mellitus, insulin-dependent 8.6 CTLA4 HLA-DRB1 INS SUMO4
30 diabetes mellitus 8.5 CTLA4 HLA-DRB1 INS SUMO4

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 12:



Diseases related to Type 1 Diabetes Mellitus 12

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 12

Drugs & Therapeutics for Type 1 Diabetes Mellitus 12

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 12

Genetic Tests for Type 1 Diabetes Mellitus 12

Anatomical Context for Type 1 Diabetes Mellitus 12

Publications for Type 1 Diabetes Mellitus 12

Variations for Type 1 Diabetes Mellitus 12

Expression for Type 1 Diabetes Mellitus 12

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 12.

Pathways for Type 1 Diabetes Mellitus 12

GO Terms for Type 1 Diabetes Mellitus 12

Cellular components related to Type 1 Diabetes Mellitus 12 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 late endosome membrane GO:0031902 8.62 HLA-DRB1 SLC11A1

Biological processes related to Type 1 Diabetes Mellitus 12 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.33 CTLA4 HLA-DRB1 SLC11A1
2 wound healing GO:0042060 9.26 INS SLC11A1
3 T cell costimulation GO:0031295 8.96 CTLA4 HLA-DRB1
4 negative regulation of T cell proliferation GO:0042130 8.62 CTLA4 HLA-DRB1

Sources for Type 1 Diabetes Mellitus 12

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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