Type 1 Diabetes Mellitus 13 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Type 1 Diabetes Mellitus 13

MalaCards integrated aliases for Type 1 Diabetes Mellitus 13:

Name: Type 1 Diabetes Mellitus 13 ¹² ¹⁵

Diabetes Mellitus, Insulin-Dependent, 13 ⁷³

Insulin-Dependent Diabetes Mellitus 13 ¹²

Iddm13 ¹²

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Endocrine, nutritional and metabolic diseases

Diabetes mellitus

Insulin-dependent diabetes mellitus

External Ids:

Disease Ontology ¹² DOID:0110752

ICD10 ³³ E10

UMLS ⁷³ C1832474

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Summaries for Type 1 Diabetes Mellitus 13

Disease Ontology : ¹² A type 1 diabetes mellituss that has material basis in mutation of the locus at chromosome 2q34.

MalaCards based summary : Type 1 Diabetes Mellitus 13, also known as diabetes mellitus, insulin-dependent, 13, is related to diabetes mellitus, insulin-dependent and rheumatoid arthritis. An important gene associated with Type 1 Diabetes Mellitus 13 is ABCA12 (ATP Binding Cassette Subfamily A Member 12), and among its related pathways/superpathways are ICos-ICosL Pathway in T-Helper Cell and Allograft rejection. Related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

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Related Diseases for Type 1 Diabetes Mellitus 13

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune	Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3	Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5	Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7	Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10	Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12	Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15	Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 13 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)

#	Related Disease	Score	Top Affiliating Genes
1	diabetes mellitus, insulin-dependent	29.2	CTLA4 GAD2 INS PTPRN
2	rheumatoid arthritis	28.4	CD80 CD86 CTLA4 SLC11A1
3	diabetes mellitus, insulin-dependent, 13	11.5
4	autoimmune polyendocrine syndrome, type ii	10.1	GAD2 INS
5	myositis fibrosa	10.0	CD80 CD86
6	arthritis	9.9
7	diabetes mellitus, ketosis-prone	9.9	GAD2 INS
8	stiff-person syndrome	9.9	GAD2 INS
9	type 1 diabetes mellitus 2	9.9	CTLA4 INS
10	exanthema subitum	9.9	CD80 CD86
11	type 1 diabetes mellitus 11	9.8	CTLA4 INS
12	type 1 diabetes mellitus 12	9.6	CTLA4 INS SLC11A1
13	type 1 diabetes mellitus 5	9.6	CTLA4 INS
14	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	9.5	CTLA4 GAD2 INS
15	paracoccidioidomycosis	9.4	CD86 CTLA4
16	type 1 diabetes mellitus 6	9.4	CD80 CD86 INS
17	type 1 diabetes mellitus 7	9.3	INS PTPRN SLC11A1
18	glucose metabolism disease	9.1	GAD2 INS PTPRN
19	acquired metabolic disease	9.1	GAD2 INS PTPRN
20	autoimmune disease	8.9	CD80 CTLA4 GAD2 INS
21	diabetes mellitus	8.0	CTLA4 GAD2 INS PTPRN

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 13:

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Symptoms & Phenotypes for Type 1 Diabetes Mellitus 13

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 13:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.76	ABCA1 CD80 CD86 CTLA4 GAD2 IGFBP5
2	homeostasis/metabolism	MP:0005376	9.65	INS PTPRN VIL1 ABCA1 ABCA12 ABCA4
3	immune system	MP:0005387	9.28	ABCA1 ABCA4 CD80 CD86 CTLA4 GAD2

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Drugs & Therapeutics for Type 1 Diabetes Mellitus 13

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 13

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Genetic Tests for Type 1 Diabetes Mellitus 13

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Anatomical Context for Type 1 Diabetes Mellitus 13

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Publications for Type 1 Diabetes Mellitus 13

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Genes for Type 1 Diabetes Mellitus 13

Genes related to Type 1 Diabetes Mellitus 13 (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ABCA12	ATP Binding Cassette Subfamily A Member 12	Protein Coding	15.7	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	VIL1	Villin 1	Protein Coding	15.62	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	SLC11A1	Solute Carrier Family 11 Member 1	Protein Coding	15.28	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	IGFBP5	Insulin Like Growth Factor Binding Protein 5	Protein Coding	15.13	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	ABCA4	ATP Binding Cassette Subfamily A Member 4	Protein Coding	14.66	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	GAD2	Glutamate Decarboxylase 2	Protein Coding	14.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	14.14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	CD86	CD86 Molecule	Protein Coding	13.72	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	13.66	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	INS	Insulin	Protein Coding	13.62	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	PTPRN	Protein Tyrosine Phosphatase, Receptor Type N	Protein Coding	5.19	DISEASES inferred ¹⁵
12	CD80	CD80 Molecule	Protein Coding	3.82	DISEASES inferred ¹⁵

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Variations for Type 1 Diabetes Mellitus 13

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Expression for Type 1 Diabetes Mellitus 13

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 13.

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Pathways for Type 1 Diabetes Mellitus 13

Pathways related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	ICos-ICosL Pathway in T-Helper Cell ⁶⁴ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁴ CD28 Signaling in T-Helper Cell ⁶⁴	12.01	CD80 CD86 CTLA4
2	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	11.84	CD80 CD86 CTLA4 GAD2 INS PTPRN
3	CD28 co-stimulation ⁶⁶ Show member pathways Activation of AKT2 ⁶⁶ CD28 dependent PI3K/Akt signaling ⁶⁶ CD28 dependent Vav1 pathway ⁶⁶ Costimulation by the CD28 family ⁶⁶ VEGFR2 mediated vascular permeability ⁶⁶	11.78	CD80 CD86 CTLA4
4	Cell adhesion molecules (CAMs) ³⁷	11.66	CD80 CD86 CTLA4
5	Rheumatoid arthritis ³⁷	11.39	CD80 CD86 CTLA4
6	CTLA4 Signaling ⁶⁴	11.18	CD80 CD86 CTLA4
7	Th2 Differentiation Pathway ⁶⁵	11.14	CD80 CD86
8	Nur77 Signaling in T-Cell ⁶⁴	10.98	CD80 CD86
9	Inflammatory Response Pathway ¹	10.92	CD80 CD86
10	T Cell Co-Signaling Pathway: Ligand-Receptor Interactions ⁶⁵	10.9	CD80 CD86 CTLA4

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GO Terms for Type 1 Diabetes Mellitus 13

Cellular components related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.65	ABCA1 ABCA12 CD80 CD86 CTLA4 GAD2
2	external side of plasma membrane	GO:0009897	9.46	ABCA1 CD80 CD86 CTLA4
3	protein complex involved in cell adhesion	GO:0098636	8.62	CD80 CTLA4

Biological processes related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.78	CD80 CD86 CTLA4 SLC11A1
2	cellular response to lipopolysaccharide	GO:0071222	9.61	ABCA1 CD80 CD86
3	lipid transport	GO:0006869	9.58	ABCA1 ABCA12 ABCA4
4	response to bacterium	GO:0009617	9.51	SLC11A1 VIL1
5	lung alveolus development	GO:0048286	9.49	ABCA12 IGFBP5
6	phospholipid translocation	GO:0045332	9.46	ABCA1 ABCA4
7	positive regulation of cholesterol efflux	GO:0010875	9.37	ABCA1 ABCA12
8	T cell costimulation	GO:0031295	9.33	CD80 CD86 CTLA4
9	positive regulation of interleukin-2 biosynthetic process	GO:0045086	9.32	CD80 CD86
10	phospholipid efflux	GO:0033700	9.26	ABCA1 ABCA12
11	negative regulation of T cell proliferation	GO:0042130	9.13	CD80 CD86 CTLA4
12	positive regulation of protein kinase B signaling	GO:0051897	8.92	CD80 CD86 IGFBP5 INS

Molecular functions related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATPase activity	GO:0016887	9.43	ABCA1 ABCA12 ABCA4
2	coreceptor activity	GO:0015026	9.16	CD80 CD86
3	phospholipid transporter activity	GO:0005548	8.96	ABCA1 ABCA4
4	ATPase activity, coupled to transmembrane movement of substances	GO:0042626	8.8	ABCA1 ABCA12 ABCA4

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Sources for Type 1 Diabetes Mellitus 13

¹ BioSystems

² BitterDB

³ CDC

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¹⁰ dbSNP

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²⁵ Genetics Home Reference

²⁶ GenomeRNAi

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³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

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⁴¹ MalaCards

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⁴⁸ NCBI Bookshelf

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⁵² NIH Clinical Center

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⁵⁵ Novoseek

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⁵⁷ OMIM

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⁵⁹ Orphanet

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⁶¹ PharmGKB

⁶² PubMed

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⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

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⁷⁶ Wikipedia