MCID: TYP037
MIFTS: 29

Type 1 Diabetes Mellitus 13

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 13

MalaCards integrated aliases for Type 1 Diabetes Mellitus 13:

Name: Type 1 Diabetes Mellitus 13 12 15
Diabetes Mellitus, Insulin-Dependent, 13 73
Insulin-Dependent Diabetes Mellitus 13 12
Iddm13 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110752
ICD10 33 E10
UMLS 73 C1832474

Summaries for Type 1 Diabetes Mellitus 13

Disease Ontology : 12 A type 1 diabetes mellituss that has material basis in mutation of the locus at chromosome 2q34.

MalaCards based summary : Type 1 Diabetes Mellitus 13, also known as diabetes mellitus, insulin-dependent, 13, is related to diabetes mellitus, insulin-dependent and rheumatoid arthritis. An important gene associated with Type 1 Diabetes Mellitus 13 is ABCA12 (ATP Binding Cassette Subfamily A Member 12), and among its related pathways/superpathways are ICos-ICosL Pathway in T-Helper Cell and Allograft rejection. Affiliated tissues include t cells, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Type 1 Diabetes Mellitus 13

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 13 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent 30.9 CTLA4 GAD2 INS PTPRN
2 rheumatoid arthritis 29.7 CD80 CD86 CTLA4 SLC11A1
3 diabetes mellitus, insulin-dependent, 13 11.8
4 perrault syndrome 1 11.1
5 arthritis 10.1
6 autoimmune polyendocrine syndrome, type ii 10.1 GAD2 INS
7 diabetes mellitus, ketosis-prone 10.0 GAD2 INS
8 sulfamethoxazole allergy 10.0 CD80 CD86
9 myositis fibrosa 10.0 CD80 CD86
10 stiff-person syndrome 10.0 GAD2 INS
11 primary biliary cholangitis 10.0 ABCA1 CTLA4
12 autoimmune peripheral neuropathy 10.0 CD80 CD86
13 exanthema subitum 10.0 CD80 CD86
14 type 1 diabetes mellitus 11 10.0 CTLA4 INS
15 type 1 diabetes mellitus 5 9.9 CTLA4 INS
16 type 1 diabetes mellitus 12 9.9 CTLA4 INS SLC11A1
17 maturity-onset diabetes of the young, type 13 9.9 INS PTPRN
18 autoimmune disease of endocrine system 9.9 CTLA4 INS
19 type 1 diabetes mellitus 6 9.9 CD80 CD86 INS
20 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9 CTLA4 GAD2 INS
21 gastrointestinal system benign neoplasm 9.8 INS PTPRN
22 type 1 diabetes mellitus 7 9.8 INS PTPRN SLC11A1
23 immune system disease 9.8 CD80 CD86 CTLA4
24 pancreatic cystadenoma 9.8 GAD2 INS PTPRN
25 paracoccidioidomycosis 9.8 CD86 CTLA4
26 glucose metabolism disease 9.8 GAD2 INS PTPRN
27 maturity-onset diabetes of the young, type 6 9.8 INS PTPRN
28 diabetes mellitus 9.6 CTLA4 GAD2 INS PTPRN
29 autoimmune disease 9.6 CD80 CTLA4 GAD2 INS SLC11A1

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 13:



Diseases related to Type 1 Diabetes Mellitus 13

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 13

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 13:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 ABCA1 CD80 CD86 CTLA4 GAD2 IGFBP5
2 homeostasis/metabolism MP:0005376 9.65 ABCA1 ABCA12 ABCA4 CD86 CTLA4 GAD2
3 immune system MP:0005387 9.28 ABCA1 ABCA4 CD80 CD86 CTLA4 GAD2

Drugs & Therapeutics for Type 1 Diabetes Mellitus 13

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 13

Genetic Tests for Type 1 Diabetes Mellitus 13

Anatomical Context for Type 1 Diabetes Mellitus 13

MalaCards organs/tissues related to Type 1 Diabetes Mellitus 13:

41
T Cells

Publications for Type 1 Diabetes Mellitus 13

Variations for Type 1 Diabetes Mellitus 13

Expression for Type 1 Diabetes Mellitus 13

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 13.

Pathways for Type 1 Diabetes Mellitus 13

GO Terms for Type 1 Diabetes Mellitus 13

Cellular components related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.81 ABCA1 ABCA12 CD80 CD86 CTLA4 GAD2
2 external side of plasma membrane GO:0009897 9.26 ABCA1 CD80 CD86 CTLA4
3 protein complex involved in cell adhesion GO:0098636 8.62 CD80 CTLA4

Biological processes related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.76 CD80 CD86 CTLA4 SLC11A1
2 cellular response to lipopolysaccharide GO:0071222 9.61 ABCA1 CD80 CD86
3 lipid transport GO:0006869 9.58 ABCA1 ABCA12 ABCA4
4 lung alveolus development GO:0048286 9.49 ABCA12 IGFBP5
5 phospholipid translocation GO:0045332 9.48 ABCA1 ABCA4
6 positive regulation of cholesterol efflux GO:0010875 9.37 ABCA1 ABCA12
7 T cell costimulation GO:0031295 9.33 CD80 CD86 CTLA4
8 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.32 CD80 CD86
9 phospholipid efflux GO:0033700 9.26 ABCA1 ABCA12
10 negative regulation of T cell proliferation GO:0042130 9.13 CD80 CD86 CTLA4
11 positive regulation of protein kinase B signaling GO:0051897 8.92 CD80 CD86 IGFBP5 INS

Molecular functions related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.5 ABCA1 ABCA12 ABCA4
2 coreceptor activity GO:0015026 9.26 CD80 CD86
3 phospholipid transporter activity GO:0005548 9.16 ABCA1 ABCA4
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.13 ABCA1 ABCA12 ABCA4
5 lipid transporter activity GO:0005319 8.8 ABCA1 ABCA12 ABCA4

Sources for Type 1 Diabetes Mellitus 13

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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