MCID: TYP037
MIFTS: 27

Type 1 Diabetes Mellitus 13

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 13

MalaCards integrated aliases for Type 1 Diabetes Mellitus 13:

Name: Type 1 Diabetes Mellitus 13 12 15
Diabetes Mellitus, Insulin-Dependent, 13 74
Insulin-Dependent Diabetes Mellitus 13 12
Iddm13 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110752
ICD10 34 E10
UMLS 74 C1832474

Summaries for Type 1 Diabetes Mellitus 13

Disease Ontology : 12 A type 1 diabetes mellituss that has material basis in mutation of the locus at chromosome 2q34.

MalaCards based summary : Type 1 Diabetes Mellitus 13, also known as diabetes mellitus, insulin-dependent, 13, is related to diabetes mellitus, insulin-dependent and rheumatoid arthritis. An important gene associated with Type 1 Diabetes Mellitus 13 is ABCA12 (ATP Binding Cassette Subfamily A Member 12), and among its related pathways/superpathways are Allograft rejection and ICos-ICosL Pathway in T-Helper Cell. Related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Type 1 Diabetes Mellitus 13

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 13:



Diseases related to Type 1 Diabetes Mellitus 13

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 13

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 13:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 ABCA1 CD80 CD86 CTLA4 GAD2 IGFBP5
2 homeostasis/metabolism MP:0005376 9.65 ABCA1 ABCA12 ABCA4 CD86 CTLA4 GAD2
3 immune system MP:0005387 9.23 ABCA1 ABCA4 CD80 CD86 CTLA4 GAD2

Drugs & Therapeutics for Type 1 Diabetes Mellitus 13

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 13

Genetic Tests for Type 1 Diabetes Mellitus 13

Anatomical Context for Type 1 Diabetes Mellitus 13

Publications for Type 1 Diabetes Mellitus 13

Variations for Type 1 Diabetes Mellitus 13

Expression for Type 1 Diabetes Mellitus 13

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 13.

Pathways for Type 1 Diabetes Mellitus 13

GO Terms for Type 1 Diabetes Mellitus 13

Cellular components related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.81 ABCA1 ABCA12 CD80 CD86 CTLA4 GAD2
2 external side of plasma membrane GO:0009897 9.26 ABCA1 CD80 CD86 CTLA4
3 protein complex involved in cell adhesion GO:0098636 8.62 CD80 CTLA4

Biological processes related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.76 CD80 CD86 CTLA4 SLC11A1
2 cytokine-mediated signaling pathway GO:0019221 9.69 CD80 CD86 PTPRN
3 positive regulation of protein kinase B signaling GO:0051897 9.61 CD80 CD86 IGFBP5
4 cellular response to lipopolysaccharide GO:0071222 9.58 ABCA1 CD80 CD86
5 lipid transport GO:0006869 9.54 ABCA1 ABCA12 ABCA4
6 lung alveolus development GO:0048286 9.49 ABCA12 IGFBP5
7 phospholipid translocation GO:0045332 9.48 ABCA1 ABCA4
8 positive regulation of cholesterol efflux GO:0010875 9.32 ABCA1 ABCA12
9 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.26 CD80 CD86
10 phospholipid efflux GO:0033700 9.16 ABCA1 ABCA12
11 T cell costimulation GO:0031295 9.13 CD80 CD86 CTLA4
12 negative regulation of T cell proliferation GO:0042130 8.8 CD80 CD86 CTLA4

Molecular functions related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.5 ABCA1 ABCA12 ABCA4
2 coreceptor activity GO:0015026 9.26 CD80 CD86
3 phospholipid transporter activity GO:0005548 9.16 ABCA1 ABCA4
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.13 ABCA1 ABCA12 ABCA4
5 lipid transporter activity GO:0005319 8.8 ABCA1 ABCA12 ABCA4

Sources for Type 1 Diabetes Mellitus 13

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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