MCID: TYP037
MIFTS: 26

Type 1 Diabetes Mellitus 13

Categories: Metabolic diseases, Endocrine diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 13

MalaCards integrated aliases for Type 1 Diabetes Mellitus 13:

Name: Type 1 Diabetes Mellitus 13 12 15
Diabetes Mellitus, Insulin-Dependent, 13 73
Insulin-Dependent Diabetes Mellitus 13 12
Iddm13 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110752
ICD10 33 E10
UMLS 73 C1832474

Summaries for Type 1 Diabetes Mellitus 13

Disease Ontology : 12 A type 1 diabetes mellituss that has material basis in mutation of the locus at chromosome 2q34.

MalaCards based summary : Type 1 Diabetes Mellitus 13, also known as diabetes mellitus, insulin-dependent, 13, is related to diabetes mellitus, insulin-dependent and rheumatoid arthritis. An important gene associated with Type 1 Diabetes Mellitus 13 is ABCA12 (ATP Binding Cassette Subfamily A Member 12), and among its related pathways/superpathways are ICos-ICosL Pathway in T-Helper Cell and Allograft rejection. Related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Type 1 Diabetes Mellitus 13

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 13 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent 29.2 CTLA4 GAD2 INS PTPRN
2 rheumatoid arthritis 28.4 CD80 CD86 CTLA4 SLC11A1
3 diabetes mellitus, insulin-dependent, 13 11.5
4 autoimmune polyendocrine syndrome, type ii 10.1 GAD2 INS
5 myositis fibrosa 10.0 CD80 CD86
6 arthritis 9.9
7 diabetes mellitus, ketosis-prone 9.9 GAD2 INS
8 stiff-person syndrome 9.9 GAD2 INS
9 type 1 diabetes mellitus 2 9.9 CTLA4 INS
10 exanthema subitum 9.9 CD80 CD86
11 type 1 diabetes mellitus 11 9.8 CTLA4 INS
12 type 1 diabetes mellitus 12 9.6 CTLA4 INS SLC11A1
13 type 1 diabetes mellitus 5 9.6 CTLA4 INS
14 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.5 CTLA4 GAD2 INS
15 paracoccidioidomycosis 9.4 CD86 CTLA4
16 type 1 diabetes mellitus 6 9.4 CD80 CD86 INS
17 type 1 diabetes mellitus 7 9.3 INS PTPRN SLC11A1
18 glucose metabolism disease 9.1 GAD2 INS PTPRN
19 acquired metabolic disease 9.1 GAD2 INS PTPRN
20 autoimmune disease 8.9 CD80 CTLA4 GAD2 INS
21 diabetes mellitus 8.0 CTLA4 GAD2 INS PTPRN

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 13:



Diseases related to Type 1 Diabetes Mellitus 13

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 13

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 13:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 ABCA1 CD80 CD86 CTLA4 GAD2 IGFBP5
2 homeostasis/metabolism MP:0005376 9.65 INS PTPRN VIL1 ABCA1 ABCA12 ABCA4
3 immune system MP:0005387 9.28 ABCA1 ABCA4 CD80 CD86 CTLA4 GAD2

Drugs & Therapeutics for Type 1 Diabetes Mellitus 13

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 13

Genetic Tests for Type 1 Diabetes Mellitus 13

Anatomical Context for Type 1 Diabetes Mellitus 13

Publications for Type 1 Diabetes Mellitus 13

Variations for Type 1 Diabetes Mellitus 13

Expression for Type 1 Diabetes Mellitus 13

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 13.

Pathways for Type 1 Diabetes Mellitus 13

GO Terms for Type 1 Diabetes Mellitus 13

Cellular components related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.65 ABCA1 ABCA12 CD80 CD86 CTLA4 GAD2
2 external side of plasma membrane GO:0009897 9.46 ABCA1 CD80 CD86 CTLA4
3 protein complex involved in cell adhesion GO:0098636 8.62 CD80 CTLA4

Biological processes related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.78 CD80 CD86 CTLA4 SLC11A1
2 cellular response to lipopolysaccharide GO:0071222 9.61 ABCA1 CD80 CD86
3 lipid transport GO:0006869 9.58 ABCA1 ABCA12 ABCA4
4 response to bacterium GO:0009617 9.51 SLC11A1 VIL1
5 lung alveolus development GO:0048286 9.49 ABCA12 IGFBP5
6 phospholipid translocation GO:0045332 9.46 ABCA1 ABCA4
7 positive regulation of cholesterol efflux GO:0010875 9.37 ABCA1 ABCA12
8 T cell costimulation GO:0031295 9.33 CD80 CD86 CTLA4
9 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.32 CD80 CD86
10 phospholipid efflux GO:0033700 9.26 ABCA1 ABCA12
11 negative regulation of T cell proliferation GO:0042130 9.13 CD80 CD86 CTLA4
12 positive regulation of protein kinase B signaling GO:0051897 8.92 CD80 CD86 IGFBP5 INS

Molecular functions related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.43 ABCA1 ABCA12 ABCA4
2 coreceptor activity GO:0015026 9.16 CD80 CD86
3 phospholipid transporter activity GO:0005548 8.96 ABCA1 ABCA4
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 8.8 ABCA1 ABCA12 ABCA4

Sources for Type 1 Diabetes Mellitus 13

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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