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MCID: TYP037
MIFTS: 28

Type 1 Diabetes Mellitus 13

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases
Genes Tissues Related diseases Pathways
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Aliases & Classifications for Type 1 Diabetes Mellitus 13

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MalaCards integrated aliases for Type 1 Diabetes Mellitus 13:

Name: Type 1 Diabetes Mellitus 13 12 15
Diabetes Mellitus, Insulin-Dependent, 13 74
Insulin-Dependent Diabetes Mellitus 13 12
Iddm13 12

Classifications:

MalaCards categories:
Global: Metabolic diseases Genetic diseases
Anatomical: Endocrine diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:0110752
ICD10 34 E10
UMLS 74 C1832474
Sources

Summaries for Type 1 Diabetes Mellitus 13

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Disease Ontology : 12 A type 1 diabetes mellituss that has material basis in mutation of the locus at chromosome 2q34.

MalaCards based summary : Type 1 Diabetes Mellitus 13, also known as diabetes mellitus, insulin-dependent, 13, is related to diabetes mellitus, insulin-dependent and rheumatoid arthritis. An important gene associated with Type 1 Diabetes Mellitus 13 is ABCA12 (ATP Binding Cassette Subfamily A Member 12), and among its related pathways/superpathways are Allograft rejection and ICos-ICosL Pathway in T-Helper Cell. Affiliated tissues include t cells, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

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Related Diseases for Type 1 Diabetes Mellitus 13

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Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 13 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent 31.3 CTLA4 GAD2 PTPRN
2 rheumatoid arthritis 29.4 CD80 CD86 CTLA4 SLC11A1
3 diabetes mellitus, insulin-dependent, 13 12.1
4 cone-rod dystrophy and hearing loss 2 11.1
5 diabetes mellitus, insulin-dependent, 12 10.2
6 type 1 diabetes mellitus 12 10.1 CTLA4 SLC11A1
7 diabetes mellitus, insulin-dependent, 7 10.1
8 arthritis 10.1
9 type 1 diabetes mellitus 7 10.1 PTPRN SLC11A1
10 sulfamethoxazole allergy 10.0 CD80 CD86
11 primary biliary cholangitis 10.0 ABCA1 CTLA4
12 type 1 diabetes mellitus 6 10.0 CD80 CD86
13 myositis fibrosa 10.0 CD80 CD86
14 pancreatic cystadenoma 10.0 GAD2 PTPRN
15 autoimmune peripheral neuropathy 9.9 CD80 CD86
16 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9 CTLA4 GAD2
17 exanthema subitum 9.9 CD80 CD86
18 paracoccidioidomycosis 9.8 CD86 CTLA4
19 multiple sclerosis 9.4 CD80 CD86 CTLA4

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 13:



Diseases related to Type 1 Diabetes Mellitus 13
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Symptoms & Phenotypes for Type 1 Diabetes Mellitus 13

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MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 13:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 ABCA1 CD80 CD86 CTLA4 GAD2 IGFBP5
2 homeostasis/metabolism MP:0005376 9.65 ABCA1 ABCA12 ABCA4 CD86 CTLA4 GAD2
3 immune system MP:0005387 9.23 ABCA1 ABCA4 CD80 CD86 CTLA4 GAD2
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Drugs & Therapeutics for Type 1 Diabetes Mellitus 13

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Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 13

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Genetic Tests for Type 1 Diabetes Mellitus 13

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Anatomical Context for Type 1 Diabetes Mellitus 13

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MalaCards organs/tissues related to Type 1 Diabetes Mellitus 13:

42
T Cells
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Publications for Type 1 Diabetes Mellitus 13

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Variations for Type 1 Diabetes Mellitus 13

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Expression for Type 1 Diabetes Mellitus 13

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Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 13.
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Pathways for Type 1 Diabetes Mellitus 13

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Pathways related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 38 1
Show member pathways
 12.29 CD80 CD86 CTLA4 GAD2 PTPRN
2
ICos-ICosL Pathway in T-Helper Cell 65
Show member pathways
 12.03 CD80 CD86 CTLA4
3
CD28 co-stimulation 67
Show member pathways
 11.78 CD80 CD86 CTLA4
4
Cell adhesion molecules (CAMs) 38
11.66 CD80 CD86 CTLA4
5
Rheumatoid arthritis 38
11.39 CD80 CD86 CTLA4
6
B Cell Development Pathways 66
11.25 CD80 CD86
7
Interleukin-10 signaling 67
11.2 CD80 CD86
8
DNA damage_Role of Brca1 and Brca2 in DNA repair 23
11.18 CD80 CD86 CTLA4
9
Th2 Differentiation Pathway 66
11.16 CD80 CD86
10
Nur77 Signaling in T-Cell 65
11 CD80 CD86
11
CTLA4 Signaling 65
10.98 CD80 CD86 CTLA4
12
Inflammatory Response Pathway 1
10.95 CD80 CD86
13
T Cell Co-Signaling Pathway: Ligand-Receptor Interactions 66
10.56 CD80 CD86 CTLA4
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GO Terms for Type 1 Diabetes Mellitus 13

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Cellular components related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.81 ABCA1 ABCA12 CD80 CD86 CTLA4 PTPRN
2 external side of plasma membrane GO:0009897 9.26 ABCA1 CD80 CD86 CTLA4
3 protein complex involved in cell adhesion GO:0098636 8.62 CD80 CTLA4

Biological processes related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.76 CD80 CD86 CTLA4 SLC11A1
2 cytokine-mediated signaling pathway GO:0019221 9.69 CD80 CD86 PTPRN
3 positive regulation of protein kinase B signaling GO:0051897 9.61 IGFBP5 CD80 CD86
4 cellular response to lipopolysaccharide GO:0071222 9.58 ABCA1 CD80 CD86
5 lipid transport GO:0006869 9.54 ABCA1 ABCA12 ABCA4
6 lung alveolus development GO:0048286 9.49 ABCA12 IGFBP5
7 phospholipid translocation GO:0045332 9.48 ABCA1 ABCA4
8 positive regulation of cholesterol efflux GO:0010875 9.32 ABCA1 ABCA12
9 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.26 CD80 CD86
10 phospholipid efflux GO:0033700 9.16 ABCA1 ABCA12
11 T cell costimulation GO:0031295 9.13 CD80 CD86 CTLA4
12 negative regulation of T cell proliferation GO:0042130 8.8 CTLA4 CD86 CD80

Molecular functions related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.5 ABCA1 ABCA12 ABCA4
2 coreceptor activity GO:0015026 9.26 CD80 CD86
3 phospholipid transporter activity GO:0005548 9.16 ABCA1 ABCA4
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.13 ABCA1 ABCA12 ABCA4
5 lipid transporter activity GO:0005319 8.8 ABCA1 ABCA12 ABCA4
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Sources for Type 1 Diabetes Mellitus 13

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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