Type 1 Diabetes Mellitus 13 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Type 1 Diabetes Mellitus 13

MalaCards integrated aliases for Type 1 Diabetes Mellitus 13:

Name: Type 1 Diabetes Mellitus 13 ¹² ¹⁵

Diabetes Mellitus, Insulin-Dependent, 13 ⁷⁴

Insulin-Dependent Diabetes Mellitus 13 ¹²

Iddm13 ¹²

Classifications:

MalaCards categories:
Global: Metabolic diseases Genetic diseases
Anatomical: Endocrine diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Endocrine, nutritional and metabolic diseases

Diabetes mellitus

Insulin-dependent diabetes mellitus

External Ids:

Disease Ontology ¹² DOID:0110752

ICD10 ³⁴ E10

UMLS ⁷⁴ C1832474

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Summaries for Type 1 Diabetes Mellitus 13

Disease Ontology : ¹² A type 1 diabetes mellituss that has material basis in mutation of the locus at chromosome 2q34.

MalaCards based summary : Type 1 Diabetes Mellitus 13, also known as diabetes mellitus, insulin-dependent, 13, is related to diabetes mellitus, insulin-dependent and rheumatoid arthritis. An important gene associated with Type 1 Diabetes Mellitus 13 is ABCA12 (ATP Binding Cassette Subfamily A Member 12), and among its related pathways/superpathways are Allograft rejection and ICos-ICosL Pathway in T-Helper Cell. Related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

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Related Diseases for Type 1 Diabetes Mellitus 13

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune	Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3	Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5	Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7	Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10	Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12	Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15	Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 13 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)

#	Related Disease	Score	Top Affiliating Genes
1	diabetes mellitus, insulin-dependent	31.2	PTPRN GAD2 CTLA4
2	rheumatoid arthritis	29.5	CTLA4 CD86 CD80 SLC11A1
3	diabetes mellitus, insulin-dependent, 13	11.8
4	perrault syndrome 1	11.1
5	type 1 diabetes mellitus 12	10.1	SLC11A1 CTLA4
6	arthritis	10.1
7	type 1 diabetes mellitus 7	10.1	SLC11A1 PTPRN
8	primary biliary cholangitis	10.0	CTLA4 ABCA1
9	sulfamethoxazole allergy	10.0	CD86 CD80
10	type 1 diabetes mellitus 6	10.0	CD86 CD80
11	myositis fibrosa	10.0	CD86 CD80
12	pancreatic cystadenoma	10.0	GAD2 PTPRN
13	autoimmune peripheral neuropathy	9.9	CD80 CD86
14	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	9.9	CTLA4 GAD2
15	exanthema subitum	9.9	CD80 CD86
16	paracoccidioidomycosis	9.8	CD86 CTLA4
17	multiple sclerosis	9.4	CD80 CD86 CTLA4

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 13:

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Symptoms & Phenotypes for Type 1 Diabetes Mellitus 13

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 13:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.7	ABCA1 CD80 CD86 CTLA4 GAD2 IGFBP5
2	homeostasis/metabolism	MP:0005376	9.65	ABCA1 ABCA12 ABCA4 CD86 CTLA4 GAD2
3	immune system	MP:0005387	9.23	ABCA1 ABCA4 CD80 CD86 CTLA4 GAD2

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Drugs & Therapeutics for Type 1 Diabetes Mellitus 13

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 13

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Genetic Tests for Type 1 Diabetes Mellitus 13

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Anatomical Context for Type 1 Diabetes Mellitus 13

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Publications for Type 1 Diabetes Mellitus 13

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Genes for Type 1 Diabetes Mellitus 13

Genes related to Type 1 Diabetes Mellitus 13 (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ABCA12	ATP Binding Cassette Subfamily A Member 12	Protein Coding	15.72	DISEASES inferred ¹⁵
2	VIL1	Villin 1	Protein Coding	15.59	DISEASES inferred ¹⁵
3	SLC11A1	Solute Carrier Family 11 Member 1	Protein Coding	15.19	DISEASES inferred ¹⁵
4	IGFBP5	Insulin Like Growth Factor Binding Protein 5	Protein Coding	15.1	DISEASES inferred ¹⁵
5	ABCA4	ATP Binding Cassette Subfamily A Member 4	Protein Coding	14.64	DISEASES inferred ¹⁵
6	GAD2	Glutamate Decarboxylase 2	Protein Coding	14.25	DISEASES inferred ¹⁵
7	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	14.17	DISEASES inferred ¹⁵
8	CD86	CD86 Molecule	Protein Coding	13.69	DISEASES inferred ¹⁵
9	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	13.37	DISEASES inferred ¹⁵
10	PTPRN	Protein Tyrosine Phosphatase Receptor Type N	Protein Coding	5.2	DISEASES inferred ¹⁵
11	SPON1	Spondin 1	Protein Coding	5.09	DISEASES inferred ¹⁵
12	CD80	CD80 Molecule	Protein Coding	3.72	DISEASES inferred ¹⁵

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Variations for Type 1 Diabetes Mellitus 13

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Expression for Type 1 Diabetes Mellitus 13

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 13.

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Pathways for Type 1 Diabetes Mellitus 13

Pathways related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ¹ ³⁸ Show member pathways Antigen processing and presentation ³⁸ Asthma ³⁸ Autoimmune thyroid disease ³⁸ CTL Mediated Apoptosis ⁶⁵ Graft-versus-host disease ³⁸ Intestinal immune network for IgA production ³⁸ THC Differentiation Pathway ⁶⁵ Type I diabetes mellitus ³⁸ Viral myocarditis ³⁸	12.29	CD80 CD86 CTLA4 GAD2 PTPRN
2	ICos-ICosL Pathway in T-Helper Cell ⁶⁵ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁵ CD28 Signaling in T-Helper Cell ⁶⁵	12.03	CD80 CD86 CTLA4
3	CD28 co-stimulation ⁶⁷ Show member pathways Activation of AKT2 ⁶⁷ CD28 dependent PI3K/Akt signaling ⁶⁷ CD28 dependent Vav1 pathway ⁶⁷ Costimulation by the CD28 family ⁶⁷ VEGFR2 mediated vascular permeability ⁶⁷	11.78	CD80 CD86 CTLA4
4	Cell adhesion molecules (CAMs) ³⁸	11.66	CD80 CD86 CTLA4
5	Rheumatoid arthritis ³⁸	11.39	CD80 CD86 CTLA4
6	B Cell Development Pathways ⁶⁶	11.25	CD80 CD86
7	Interleukin-10 signaling ⁶⁷	11.2	CD80 CD86
8	DNA damage_Role of Brca1 and Brca2 in DNA repair ²³	11.18	CD80 CD86 CTLA4
9	Th2 Differentiation Pathway ⁶⁶	11.16	CD80 CD86
10	Nur77 Signaling in T-Cell ⁶⁵	11	CD80 CD86
11	CTLA4 Signaling ⁶⁵	10.98	CD80 CD86 CTLA4
12	Inflammatory Response Pathway ¹	10.95	CD80 CD86
13	T Cell Co-Signaling Pathway: Ligand-Receptor Interactions ⁶⁶	10.56	CD80 CD86 CTLA4

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GO Terms for Type 1 Diabetes Mellitus 13

Cellular components related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.81	ABCA1 ABCA12 CD80 CD86 CTLA4 GAD2
2	external side of plasma membrane	GO:0009897	9.26	ABCA1 CD80 CD86 CTLA4
3	protein complex involved in cell adhesion	GO:0098636	8.62	CD80 CTLA4

Biological processes related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.76	CD80 CD86 CTLA4 SLC11A1
2	cytokine-mediated signaling pathway	GO:0019221	9.69	CD80 CD86 PTPRN
3	positive regulation of protein kinase B signaling	GO:0051897	9.61	CD80 CD86 IGFBP5
4	cellular response to lipopolysaccharide	GO:0071222	9.58	ABCA1 CD80 CD86
5	lipid transport	GO:0006869	9.54	ABCA1 ABCA12 ABCA4
6	lung alveolus development	GO:0048286	9.49	ABCA12 IGFBP5
7	phospholipid translocation	GO:0045332	9.48	ABCA1 ABCA4
8	positive regulation of cholesterol efflux	GO:0010875	9.32	ABCA1 ABCA12
9	positive regulation of interleukin-2 biosynthetic process	GO:0045086	9.26	CD80 CD86
10	phospholipid efflux	GO:0033700	9.16	ABCA1 ABCA12
11	T cell costimulation	GO:0031295	9.13	CD80 CD86 CTLA4
12	negative regulation of T cell proliferation	GO:0042130	8.8	CD80 CD86 CTLA4

Molecular functions related to Type 1 Diabetes Mellitus 13 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATPase activity	GO:0016887	9.5	ABCA1 ABCA12 ABCA4
2	coreceptor activity	GO:0015026	9.26	CD80 CD86
3	phospholipid transporter activity	GO:0005548	9.16	ABCA1 ABCA4
4	ATPase activity, coupled to transmembrane movement of substances	GO:0042626	9.13	ABCA1 ABCA12 ABCA4
5	lipid transporter activity	GO:0005319	8.8	ABCA1 ABCA12 ABCA4

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Sources for Type 1 Diabetes Mellitus 13

¹ BioSystems

² BitterDB

³ CDC

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²¹ GeneAnalytics

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²³ GeneGo (Thomson Reuters)

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²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

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²⁹ GO

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³³ HPO

³⁴ ICD10

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³⁷ IUPHAR

³⁸ KEGG

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⁴⁹ NCBI Bookshelf

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⁵⁶ Novoseek

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⁷² TGDB

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⁷⁵ UMLS via Orphanet

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⁷⁷ Wikipedia