TID17
MCID: TYP039
MIFTS: 23

Type 1 Diabetes Mellitus 17 (TID17)

Categories: Endocrine diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 17

MalaCards integrated aliases for Type 1 Diabetes Mellitus 17:

Name: Type 1 Diabetes Mellitus 17 57 12 15
Diabetes Mellitus, Insulin-Dependent, 17 57 13 70
Insulin-Dependent Diabetes Mellitus 17 57 12
Iddm17 57 12
Diabetes Mellitus, Insulin-Dependent, 17; Iddm17 57
Tid17 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0110754
OMIM® 57 603266
ICD10 32 E10
MedGen 41 C1864068
UMLS 70 C1864068

Summaries for Type 1 Diabetes Mellitus 17

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 10q25.

MalaCards based summary : Type 1 Diabetes Mellitus 17, also known as diabetes mellitus, insulin-dependent, 17, is related to diabetes mellitus and type 1 diabetes mellitus. An important gene associated with Type 1 Diabetes Mellitus 17 is IDDM17 (Insulin Dependent Diabetes Mellitus 17), and among its related pathways/superpathways are p53 Signaling and Apoptosis and Autophagy. Affiliated tissues include pancreas and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

More information from OMIM: 603266

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 17

Clinical features from OMIM®:

603266 (Updated 20-May-2021)

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 17 according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.55 CLNK
2 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.55 CLNK
3 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.55 CASP7
4 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.55 CASP7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.55 CLNK
6 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.55 CASP7
7 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.55 CASP7
8 Increased shRNA abundance (Z-score > 2) GR00366-A-206 9.55 CASP7
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.55 CLNK
10 Increased shRNA abundance (Z-score > 2) GR00366-A-216 9.55 CLNK
11 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.55 CLNK
12 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.55 CASP7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.55 CASP7
14 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.55 CASP7 CLNK
15 Increased shRNA abundance (Z-score > 2) GR00366-A-86 9.55 CLNK
16 Increased shRNA abundance (Z-score > 2) GR00366-A-87 9.55 CASP7

Drugs & Therapeutics for Type 1 Diabetes Mellitus 17

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 17

Genetic Tests for Type 1 Diabetes Mellitus 17

Anatomical Context for Type 1 Diabetes Mellitus 17

MalaCards organs/tissues related to Type 1 Diabetes Mellitus 17:

40
Pancreas, Kidney

Publications for Type 1 Diabetes Mellitus 17

Articles related to Type 1 Diabetes Mellitus 17:

# Title Authors PMID Year
1
Evidence for oligogenic inheritance of type 1 diabetes in a large Bedouin Arab family. 57
9788970 1998
2
Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8. 57
8733139 1996
3
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. 57
7581446 1995
4
Tumor marker pyruvate kinase type tumor M2 in patients suffering from diabetic nephropathy. 61
12820364 2003
5
Characterization of adrenal autoantigens recognized by sera from patients with autoimmune polyglandular syndrome (APS) type I. 61
7916911 1994
6
Ophthalmological follow-up of type 1 (insulin-dependent) diabetic patients after kidney and pancreas transplantation. 61
1936705 1991

Variations for Type 1 Diabetes Mellitus 17

Expression for Type 1 Diabetes Mellitus 17

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 17.

Pathways for Type 1 Diabetes Mellitus 17

Pathways related to Type 1 Diabetes Mellitus 17 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.23 CASP7 CASP14
2 11.07 TNFRSF25 CASP7 CASP14

GO Terms for Type 1 Diabetes Mellitus 17

Biological processes related to Type 1 Diabetes Mellitus 17 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 execution phase of apoptosis GO:0097194 8.62 CASP7 CASP14

Molecular functions related to Type 1 Diabetes Mellitus 17 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type peptidase activity GO:0008234 9.16 CASP7 CASP14
2 cysteine-type endopeptidase activity GO:0004197 8.96 CASP7 CASP14
3 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 8.62 CASP7 CASP14

Sources for Type 1 Diabetes Mellitus 17

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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