T1D18
MCID: TYP040
MIFTS: 23

Type 1 Diabetes Mellitus 18 (T1D18)

Categories: Endocrine diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 18

MalaCards integrated aliases for Type 1 Diabetes Mellitus 18:

Name: Type 1 Diabetes Mellitus 18 57 12 15
Diabetes Mellitus, Insulin-Dependent, 18 57 13 70
Insulin-Dependent Diabetes Mellitus 18 57 12
Iddm18 57 12
Diabetes Mellitus, Insulin-Dependent, 18; Iddm18 57
T1d18 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0110755
OMIM® 57 605598
ICD10 32 E10
MedGen 41 C1854125
UMLS 70 C1854125

Summaries for Type 1 Diabetes Mellitus 18

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 5q31.1-q33.1.

MalaCards based summary : Type 1 Diabetes Mellitus 18, also known as diabetes mellitus, insulin-dependent, 18, is related to type 1 diabetes mellitus and diabetes mellitus. An important gene associated with Type 1 Diabetes Mellitus 18 is IDDM18 (Insulin Dependent Diabetes Mellitus 18), and among its related pathways/superpathways is NF-kappaB Signaling.

More information from OMIM: 605598

Related Diseases for Type 1 Diabetes Mellitus 18

Diseases in the Diabetes Mellitus family:

Type 1 Diabetes Mellitus 2 Type 2 Diabetes Mellitus
Type 1 Diabetes Mellitus Type 1 Diabetes Mellitus 3
Type 1 Diabetes Mellitus 4 Type 1 Diabetes Mellitus 5
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 11 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 12 Type 2 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 17
Type 2 Diabetes Mellitus 3 Diabetes Mellitus, Congenital Autoimmune
Type 1 Diabetes Mellitus 18 Type 2 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 19 Type 1 Diabetes Mellitus 20
Type 1 Diabetes Mellitus 21 Type 1 Diabetes Mellitus 22
Type 1 Diabetes Mellitus 23 Type 1 Diabetes Mellitus 24
Type 2 Diabetes 5 Rare Diabetes Mellitus Type 1
Rare Diabetes Mellitus Type 2 Rare Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus 18 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 type 1 diabetes mellitus 29.3 TNFRSF25 PTPN22 IL2RA IFIH1
2 diabetes mellitus 29.0 TNFRSF25 PTPN22 IL2RA IFIH1 IDDM18
3 rheumatoid factor-negative polyarticular juvenile idiopathic arthritis 10.1 PTPN22 IL2RA
4 hypoglycemia 10.1
5 type 1 diabetes mellitus 3 10.1 PTPN22 IL2RA
6 type 1 diabetes mellitus 24 10.0 MAS1L IFIH1
7 oligoarticular juvenile idiopathic arthritis 10.0 PTPN22 IL2RA
8 type 1 diabetes mellitus 20 10.0 MAS1L IFIH1
9 type 1 diabetes mellitus 19 10.0 TRAFD1 IFIH1
10 type 1 diabetes mellitus 12 10.0 TNFRSF25 PTPN22
11 autoimmune polyendocrine syndrome, type ii 9.9 TNFRSF25 PTPN22
12 type 1 diabetes mellitus 5 9.9 TNFRSF25 PTPN22
13 vogt-koyanagi-harada disease 9.9 PTPN22 IL2RA
14 adrenal cortical hypofunction 9.9 TNFRSF25 PTPN22
15 pernicious anemia 9.9 TNFRSF25 PTPN22
16 alopecia areata 9.9 PTPN22 IL2RA
17 adrenal cortex disease 9.9 TNFRSF25 PTPN22
18 autoimmune disease of skin and connective tissue 9.9 TNFRSF25 PTPN22
19 autoimmune disease 9.8 PTPN22 IL2RA IFIH1
20 covid-19 9.8 IL2RA IFIH1
21 autoimmune disease of endocrine system 9.7 TNFRSF25 PTPN22 IL2RA
22 lymphopenia 9.7 PTPN22 IL2RA
23 immunodeficiency 31c 9.5 TNFRSF25 PTPN22 IL2RA IFIH1
24 type 1 diabetes mellitus 2 9.5 TRAFD1 TNFRSF25 PTPN22 IL2RA
25 celiac disease 1 9.5 TNFRSF25 PTPN22 IL2RA IFIH1

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 18:



Diseases related to Type 1 Diabetes Mellitus 18

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 18

Clinical features from OMIM®:

605598 (Updated 05-Apr-2021)

Drugs & Therapeutics for Type 1 Diabetes Mellitus 18

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 18

Genetic Tests for Type 1 Diabetes Mellitus 18

Anatomical Context for Type 1 Diabetes Mellitus 18

Publications for Type 1 Diabetes Mellitus 18

Articles related to Type 1 Diabetes Mellitus 18:

# Title Authors PMID Year
1
Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele. 57
11175794 2001
2
Interleukin 12 and autoimmune diabetes. 57
11175771 2001
3
Prevalence of Celiac disease in Turkish children with type 1 diabetes mellitus and their non-diabetic first-degree relatives. 61
20533110 2010
4
[Relationship between low glomerular filtration rate, hypertension, and microalbuminuria in type 1 diabetes mellitus]. 61
15913038 2005
5
Comparison between continuous subcutaneous insulin infusion and multiple insulin injection therapy in type 1 diabetes mellitus: 18-month follow-up. 61
15251830 2002
6
Normal tissue plasminogen activator and plasminogen activator inhibitor activity in plasma from patients with type 1 diabetes mellitus. 61
1452117 1992

Variations for Type 1 Diabetes Mellitus 18

Expression for Type 1 Diabetes Mellitus 18

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 18.

Pathways for Type 1 Diabetes Mellitus 18

Pathways related to Type 1 Diabetes Mellitus 18 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 TNFRSF25 PTPN22 IL2RA IFIH1

GO Terms for Type 1 Diabetes Mellitus 18

Biological processes related to Type 1 Diabetes Mellitus 18 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interferon-beta production GO:0032728 8.96 PTPN22 IFIH1
2 positive regulation of interferon-alpha production GO:0032727 8.62 PTPN22 IFIH1

Sources for Type 1 Diabetes Mellitus 18

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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