IDDM2
MCID: TYP028
MIFTS: 24

Type 1 Diabetes Mellitus 2 (IDDM2)

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 2

MalaCards integrated aliases for Type 1 Diabetes Mellitus 2:

Name: Type 1 Diabetes Mellitus 2 12 15
Diabetes Mellitus, Insulin-Dependent, 2 74
Insulin-Dependent Diabetes Mellitus 2 12
Iddm2 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110741
ICD10 34 E10
UMLS 74 C1852092

Summaries for Type 1 Diabetes Mellitus 2

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in autosomal dominant inheritance of mutation of the INS gene on chromosome 11p15.5.

MalaCards based summary : Type 1 Diabetes Mellitus 2, also known as diabetes mellitus, insulin-dependent, 2, is related to diabetes mellitus, insulin-dependent, 2 and segawa syndrome, autosomal recessive. An important gene associated with Type 1 Diabetes Mellitus 2 is INS-IGF2 (INS-IGF2 Readthrough), and among its related pathways/superpathways are MAPK signaling pathway and Ras signaling pathway. Related phenotype is no phenotypic analysis.

Related Diseases for Type 1 Diabetes Mellitus 2

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent, 2 32.9 INS-IGF2 INS
2 segawa syndrome, autosomal recessive 10.2 INS-IGF2 INS
3 growth restriction, severe, with distinctive facies 10.2 INS-IGF2 IGF2
4 hyperproinsulinemia 10.2 INS INS-IGF2
5 maturity-onset diabetes of the young, type 10 10.2 INS INS-IGF2
6 hypoglycemic coma 10.1 INS IGF2
7 insulinomatosis and diabetes mellitus 10.1 IGF2 INS
8 fetal macrosomia 10.1 IGF2 INS
9 adult syndrome 10.1 IGF2 INS
10 rubeosis iridis 10.1 IGF2 INS
11 islet cell tumor 10.1 IGF2 INS
12 type 1 diabetes mellitus 12 10.1 INS FGF3
13 diabetes mellitus, permanent neonatal 10.1 INS-IGF2 INS
14 diabetes mellitus 10.1
15 hyperglycemia 10.1
16 lymphopenia 10.1
17 lymphomatoid papulosis 10.1
18 hyperinsulinemic hypoglycemia 10.0 INS IGF2
19 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 AIRE INS
20 pancreas disease 10.0 INS IGF2
21 type 1 diabetes mellitus 4 10.0 GIMAP5 FGF3
22 beckwith-wiedemann syndrome 9.9 INS-IGF2 INS IGF2
23 type 1 diabetes mellitus 11 9.9 INS TNFRSF25
24 diabetes mellitus, insulin-dependent 9.9 INS-IGF2 INS AIRE
25 parathyroid gland disease 9.9 AIRE FGF3
26 acromegaly 9.9 INS IGF2
27 type 1 diabetes mellitus 17 9.9 TNFRSF25 AIRE
28 adrenal cortical hypofunction 9.8 AIRE TNFRSF25
29 insulin-like growth factor i 9.8 INS IGF2
30 glucose metabolism disease 9.7 TNFRSF25 INS
31 cholangitis, primary sclerosing 9.7 TNFRSF25 AIRE
32 autoimmune disease of endocrine system 9.7 TNFRSF25 INS AIRE
33 type 1 diabetes mellitus 5 9.3 TNFRSF25 INS FGF3 AIRE

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 2:



Diseases related to Type 1 Diabetes Mellitus 2

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 2

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 2:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.92 AIRE FGF3 IGF2 INS

Drugs & Therapeutics for Type 1 Diabetes Mellitus 2

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 2

Genetic Tests for Type 1 Diabetes Mellitus 2

Anatomical Context for Type 1 Diabetes Mellitus 2

Publications for Type 1 Diabetes Mellitus 2

Variations for Type 1 Diabetes Mellitus 2

Expression for Type 1 Diabetes Mellitus 2

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 2.

Pathways for Type 1 Diabetes Mellitus 2

Pathways related to Type 1 Diabetes Mellitus 2 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.1 FGF3 IGF2 INS
2
Show member pathways
11.97 FGF3 IGF2 INS
3
Show member pathways
11.3 INS INS-IGF2
4 10.75 FGF3 IGF2
5 10.35 IGF2 INS

GO Terms for Type 1 Diabetes Mellitus 2

Cellular components related to Type 1 Diabetes Mellitus 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 FGF3 IGF2 INS INS-IGF2 TNFRSF25

Biological processes related to Type 1 Diabetes Mellitus 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.63 FGF3 IGF2 INS
2 insulin receptor signaling pathway GO:0008286 9.43 IGF2 INS
3 positive regulation of protein kinase B signaling GO:0051897 9.43 FGF3 IGF2 INS
4 glucose metabolic process GO:0006006 9.4 IGF2 INS
5 positive regulation of cell division GO:0051781 9.37 FGF3 IGF2
6 positive regulation of mitotic nuclear division GO:0045840 9.32 IGF2 INS
7 positive regulation of glycogen biosynthetic process GO:0045725 9.16 IGF2 INS
8 positive regulation of insulin receptor signaling pathway GO:0046628 8.96 IGF2 INS
9 regulation of signaling receptor activity GO:0010469 8.92 FGF3 IGF2 INS INS-IGF2

Molecular functions related to Type 1 Diabetes Mellitus 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.16 IGF2 INS
2 insulin-like growth factor receptor binding GO:0005159 8.96 IGF2 INS
3 hormone activity GO:0005179 8.8 IGF2 INS INS-IGF2

Sources for Type 1 Diabetes Mellitus 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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