MCID: TYP028
MIFTS: 23

Type 1 Diabetes Mellitus 2

Categories: Metabolic diseases, Endocrine diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 2

MalaCards integrated aliases for Type 1 Diabetes Mellitus 2:

Name: Type 1 Diabetes Mellitus 2 12 15
Diabetes Mellitus, Insulin-Dependent, 2 73
Insulin-Dependent Diabetes Mellitus 2 12
Iddm2 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110741
ICD10 33 E10
UMLS 73 C1852092

Summaries for Type 1 Diabetes Mellitus 2

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in autosomal dominant inheritance of mutation of the INS gene on chromosome 11p15.5.

MalaCards based summary : Type 1 Diabetes Mellitus 2, also known as diabetes mellitus, insulin-dependent, 2, is related to diabetes mellitus, insulin-dependent, 2 and maturity-onset diabetes of the young, type 10. An important gene associated with Type 1 Diabetes Mellitus 2 is INS (Insulin), and among its related pathways/superpathways are TGF-Beta Pathway and MAPK signaling pathway.

Related Diseases for Type 1 Diabetes Mellitus 2

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent, 2 33.0 INS INS-IGF2
2 maturity-onset diabetes of the young, type 10 10.5 INS INS-IGF2
3 segawa syndrome, autosomal recessive 10.4 INS INS-IGF2
4 hyperproinsulinemia 10.4 INS INS-IGF2
5 hypoglycemic coma 10.4 IGF2 INS
6 hyperinsulinemic hypoglycemia, familial, 2 10.4 IGF2 INS
7 growth restriction, severe, with distinctive facies 10.4 IGF2 INS-IGF2
8 fetal macrosomia 10.3 IGF2 INS
9 adult syndrome 10.3 IGF2 INS
10 islet cell tumor 10.3 IGF2 INS
11 rubeosis iridis 10.3 IGF2 INS
12 endocrine pancreas disease 10.3 IGF2 INS
13 diabetes mellitus, permanent neonatal 10.2 INS INS-IGF2
14 pancreas disease 10.2 IGF2 INS
15 glucose metabolism disease 10.1 INS TNFRSF25
16 acromegaly 10.0 IGF2 INS
17 type 1 diabetes mellitus 4 10.0 FGF3 GIMAP5
18 type 1 diabetes mellitus 13 9.9 CTLA4 INS
19 beckwith-wiedemann syndrome 9.9 IGF2 INS INS-IGF2
20 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8 CTLA4 INS
21 type 1 diabetes mellitus 17 9.8 CTLA4 TNFRSF25
22 autoimmune disease of endocrine system 9.7 CTLA4 TNFRSF25
23 autoimmune disease of gastrointestinal tract 9.6 CTLA4 TNFRSF25
24 insulin-like growth factor i 9.6 IGF2 INS
25 hypersensitivity reaction disease 9.6 CTLA4 TNFRSF25
26 hyperthyroidism 9.5 CTLA4 INS
27 immune system disease 9.5 CTLA4 TNFRSF25
28 type 1 diabetes mellitus 11 9.4 CTLA4 INS TNFRSF25
29 type 1 diabetes mellitus 12 9.2 CTLA4 FGF3 INS
30 ewing sarcoma 8.9 CTLA4 IGF2 INS
31 type 1 diabetes mellitus 5 8.6 CTLA4 FGF3 INS TNFRSF25
32 diabetes mellitus, insulin-dependent 8.3 CTLA4 IGF2 INS INS-IGF2 TNFRSF25

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 2:



Diseases related to Type 1 Diabetes Mellitus 2

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 2

Drugs & Therapeutics for Type 1 Diabetes Mellitus 2

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 2

Genetic Tests for Type 1 Diabetes Mellitus 2

Anatomical Context for Type 1 Diabetes Mellitus 2

Publications for Type 1 Diabetes Mellitus 2

Variations for Type 1 Diabetes Mellitus 2

Expression for Type 1 Diabetes Mellitus 2

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 2.

Pathways for Type 1 Diabetes Mellitus 2

GO Terms for Type 1 Diabetes Mellitus 2

Cellular components related to Type 1 Diabetes Mellitus 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 FGF3 IGF2 INS INS-IGF2 TNFRSF25

Biological processes related to Type 1 Diabetes Mellitus 2 according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.81 FGF3 IGF2 INS INS-IGF2
2 regulation of signaling receptor activity GO:0010469 9.78 FGF3 IGF2 INS INS-IGF2
3 regulation of gene expression GO:0010468 9.73 IGF2 INS INS-IGF2
4 positive regulation of protein kinase B signaling GO:0051897 9.71 FGF3 IGF2 INS
5 activation of MAPK activity GO:0000187 9.67 IGF2 INS INS-IGF2
6 glucose homeostasis GO:0042593 9.63 IGF2 INS INS-IGF2
7 response to organic substance GO:0010033 9.61 IGF2 INS INS-IGF2
8 insulin receptor signaling pathway GO:0008286 9.58 IGF2 INS
9 glucose metabolic process GO:0006006 9.58 IGF2 INS
10 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.58 IGF2 INS INS-IGF2
11 positive regulation of cell division GO:0051781 9.57 FGF3 IGF2
12 positive regulation of mitotic nuclear division GO:0045840 9.55 IGF2 INS
13 response to glucose GO:0009749 9.54 IGF2 INS INS-IGF2
14 positive regulation of glycogen biosynthetic process GO:0045725 9.52 IGF2 INS
15 response to insulin GO:0032868 9.5 IGF2 INS INS-IGF2
16 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.43 IGF2 INS INS-IGF2
17 response to nutrient levels GO:0031667 9.33 IGF2 INS INS-IGF2
18 positive regulation of MAPK cascade GO:0043410 9.26 IGF2 INS INS-IGF2 TNFRSF25
19 positive regulation of insulin receptor signaling pathway GO:0046628 8.8 IGF2 INS INS-IGF2

Molecular functions related to Type 1 Diabetes Mellitus 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 IGF2 INS INS-IGF2
2 insulin receptor binding GO:0005158 9.33 IGF2 INS INS-IGF2
3 insulin-like growth factor receptor binding GO:0005159 9.13 IGF2 INS INS-IGF2
4 receptor activator activity GO:0030546 8.8 IGF2 INS INS-IGF2

Sources for Type 1 Diabetes Mellitus 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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