T1D21
MCID: TYP054
MIFTS: 32

Type 1 Diabetes Mellitus 21 (T1D21)

Categories: Endocrine diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 21

MalaCards integrated aliases for Type 1 Diabetes Mellitus 21:

Name: Type 1 Diabetes Mellitus 21 57 12 15
Diabetes Mellitus, Insulin-Dependent, 21 57 13
Iddm21 57 12
Diabetes Mellitus, Insulin-Dependent, 21; Iddm21 57
Insulin-Dependent Diabetes Mellitus 21 12
T1d21 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0110758
OMIM® 57 612521
ICD10 32 E10
MedGen 41 C2675865

Summaries for Type 1 Diabetes Mellitus 21

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 6q25.

MalaCards based summary : Type 1 Diabetes Mellitus 21, also known as diabetes mellitus, insulin-dependent, 21, is related to primary cutaneous diffuse large b-cell lymphoma, leg type and primary mediastinal large b-cell lymphoma. An important gene associated with Type 1 Diabetes Mellitus 21 is TAGAP (T Cell Activation RhoGTPase Activating Protein), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Related phenotypes are Reduced mammosphere formation and hematopoietic system

More information from OMIM: 612521

Related Diseases for Type 1 Diabetes Mellitus 21

Diseases in the Diabetes Mellitus family:

Type 1 Diabetes Mellitus 2 Type 2 Diabetes Mellitus
Type 1 Diabetes Mellitus Type 1 Diabetes Mellitus 3
Type 1 Diabetes Mellitus 4 Type 1 Diabetes Mellitus 5
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 11 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 12 Type 2 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 17
Type 2 Diabetes Mellitus 3 Diabetes Mellitus, Congenital Autoimmune
Type 1 Diabetes Mellitus 18 Type 2 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 19 Type 1 Diabetes Mellitus 20
Type 1 Diabetes Mellitus 21 Type 1 Diabetes Mellitus 22
Type 1 Diabetes Mellitus 23 Type 1 Diabetes Mellitus 24
Type 2 Diabetes 5 Rare Diabetes Mellitus Type 1
Rare Diabetes Mellitus Type 2 Rare Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus 21 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 primary cutaneous diffuse large b-cell lymphoma, leg type 10.2 PDCD1LG2 CD274
2 primary mediastinal large b-cell lymphoma 10.2 PDCD1LG2 CD274
3 gray zone lymphoma 10.2 PDCD1LG2 CD274
4 immunodeficiency 27b 10.1 TBX21 GATA3
5 testicular lymphoma 10.1 PDCD1LG2 PDCD1 CD274
6 dermatitis, atopic, 5 10.1 TBX21 GATA3
7 gastroesophageal junction adenocarcinoma 10.1 PDCD1LG2 PDCD1 CD274
8 macular degeneration, age-related, 8 10.1 TBX21 EOMES CD28
9 aneruptive fever 10.1 TBX21 GATA3 CD28
10 myopathy, distal, 1 10.1 PDCD1LG2 PDCD1 CD274
11 autoimmune lymphoproliferative syndrome, type v 10.0 CTLA4 CD28
12 autoimmune disease of gastrointestinal tract 10.0 TBX21 MADCAM1 CTLA4
13 filariasis 10.0 PDCD1LG2 GATA3 CTLA4
14 peripheral t-cell lymphoma 10.0 PDCD1 GATA3 CD274
15 sympathetic ophthalmia 10.0 VCAM1 PDCD1 CTLA4
16 epstein-barr virus-associated gastric carcinoma 10.0 PDCD1LG2 CD274
17 exanthem 9.9 PDCD1 CTLA4 CD274
18 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.9 TBX21 CTLA4 CD28
19 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9 PDCD1 CTLA4 CD274
20 inflammatory bowel disease 18 9.9 CTLA4 CD28
21 allergic disease 9.9 PDCD1 GATA3 CTLA4
22 allergic asthma 9.9 VCAM1 GATA3 CTLA4
23 sezary's disease 9.8 GATA3 CTLA4 CD28
24 anus cancer 9.8 PDCD1 CD274
25 autoimmune peripheral neuropathy 9.8 CD28 CD276
26 myocarditis 9.8 VCAM1 CTLA4 CD274
27 lung non-squamous non-small cell carcinoma 9.8 PDCD1LG2 PDCD1 CTLA4 CD274
28 mixed oligodendroglioma-astrocytoma 9.8 PDCD1 CD276 CD274
29 skin melanoma 9.7 PDCD1LG2 PDCD1 CTLA4 CD274
30 autoimmune disease of central nervous system 9.7 VCAM1 TBX21 CTLA4 CD28
31 autoimmune disease of the nervous system 9.7 VCAM1 TBX21 CTLA4 CD28
32 type 1 diabetes mellitus 9.7 PDCD1 GCG CTLA4 CD28
33 behcet syndrome 9.7 VCAM1 TBX21 CTLA4 CD28
34 angioimmunoblastic t-cell lymphoma 9.7 TBX21 PDCD1LG2 PDCD1 CD28 CD274
35 viral infectious disease 9.7 PDCD1 CTLA4 CD28 CD274
36 bone inflammation disease 9.6 MMP13 CTLA4 CD28
37 celiac disease 1 9.6 TBX21 TAGAP GCG CTLA4 CD28
38 autoimmune disease 9.6 VCAM1 TBX21 PDCD1 CTLA4 CD28
39 autoimmune cardiomyopathy 9.6 PDCD1LG2 PDCD1 CTLA4 CD28 CD274
40 thrombocytopenia 9.5 TBX21 PDCD1 GATA3 CTLA4 CD274
41 aplastic anemia 9.4 VCAM1 TBX21 PDCD1 GATA3 CTLA4 CD28
42 multiple sclerosis 9.4 VCAM1 TAGAP PDCD1 CTLA4 CD28 CD274
43 asthma 9.2 VCAM1 TBX21 IL6R GATA3 CTLA4 CD28
44 rheumatoid arthritis 9.0 VCAM1 TAGAP PDCD1 MMP13 IL6R CTLA4
45 systemic lupus erythematosus 8.9 VCAM1 TBX21 PDCD1 IL6R GATA3 CTLA4
46 inflammatory bowel disease 8.9 VCAM1 TBX21 MMP13 MADCAM1 IL6R GCG

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 21:



Diseases related to Type 1 Diabetes Mellitus 21

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 21

Clinical features from OMIM®:

612521 (Updated 05-Mar-2021)

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 21 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD28 HOXD13 IL6R MMP13 NTAN1 VCAM1

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 21:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CD274 CD276 CD28 CTLA4 EOMES GATA3
2 cellular MP:0005384 10.02 CD274 CD28 EOMES GATA3 IL6R MMP13
3 homeostasis/metabolism MP:0005376 9.93 CD274 CD28 CTLA4 EOMES GATA3 IL6R
4 immune system MP:0005387 9.77 CD274 CD276 CD28 CTLA4 EOMES GATA3
5 neoplasm MP:0002006 9.1 CD28 EOMES IL6R PDCD1 PDCD1LG2 TBX21

Drugs & Therapeutics for Type 1 Diabetes Mellitus 21

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 21

Genetic Tests for Type 1 Diabetes Mellitus 21

Anatomical Context for Type 1 Diabetes Mellitus 21

Publications for Type 1 Diabetes Mellitus 21

Articles related to Type 1 Diabetes Mellitus 21:

# Title Authors PMID Year
1
Shared and distinct genetic variants in type 1 diabetes and celiac disease. 57
19073967 2008
2
The effectiveness of the Brush Day and Night programme in improving children's toothbrushing knowledge and behaviour. 61
29660791 2018
3
Prevalence and clinical profile of celiac disease in type 1 diabetes mellitus in north India. 61
21261730 2011
4
The influence of type-1 diabetes mellitus on dentition and oral health in children and adolescents. 61
18581583 2008
5
Autoantibodies in autoimmune polyendocrine syndrome type II. 61
12092456 2002

Variations for Type 1 Diabetes Mellitus 21

Expression for Type 1 Diabetes Mellitus 21

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 21.

Pathways for Type 1 Diabetes Mellitus 21

Pathways related to Type 1 Diabetes Mellitus 21 according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 VCAM1 TNFRSF14 PDCD1LG2 PDCD1 MADCAM1 IL6R
2
Show member pathways
13.18 VCAM1 TNFRSF14 PDCD1LG2 PDCD1 MADCAM1 CTLA4
3
Show member pathways
12.4 TBX21 IL6R GATA3 CD28
4
Show member pathways
12.37 PDCD1 GATA3 CTLA4 CD28 CD274
5
Show member pathways
11.97 TNFRSF14 PDCD1LG2 PDCD1 CTLA4 CD28 CD274
6 11.93 VCAM1 PDCD1LG2 PDCD1 MADCAM1 CTLA4 CD28
7 11.84 VCAM1 TBX21 PDCD1LG2 PDCD1 GATA3 EOMES
8 11.76 VCAM1 IL6R GATA3
9
Show member pathways
11.72 PDCD1LG2 PDCD1 CD274
10 11.57 TBX21 GATA3 EOMES
11
Show member pathways
11.53 TBX21 GATA3 CD28
12
Show member pathways
11.51 TBX21 GATA3 CTLA4
13 11.32 VCAM1 PDCD1LG2 PDCD1 MADCAM1 CTLA4 CD28
14 11.05 TBX21 GATA3 EOMES
15 10.99 PDCD1 CTLA4 CD28
16 10.77 VCAM1 GATA3

GO Terms for Type 1 Diabetes Mellitus 21

Cellular components related to Type 1 Diabetes Mellitus 21 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.28 VCAM1 TNFRSF14 PDCD1LG2 PDCD1 IL6R CTLA4
2 protein complex involved in cell adhesion GO:0098636 8.96 CTLA4 CD28

Biological processes related to Type 1 Diabetes Mellitus 21 according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.87 TNFRSF14 PDCD1LG2 PDCD1 GATA3 EOMES CTLA4
2 cell surface receptor signaling pathway GO:0007166 9.85 TNFRSF14 PDCD1LG2 CD28 CD274
3 immune response GO:0006955 9.85 TNFRSF14 PDCD1LG2 MADCAM1 CTLA4 CD28 CD274
4 T cell receptor signaling pathway GO:0050852 9.78 GATA3 CTLA4 CD28 CD276
5 adaptive immune response GO:0002250 9.73 TNFRSF14 PDCD1LG2 PDCD1 EOMES CTLA4 CD274
6 humoral immune response GO:0006959 9.67 PDCD1 GATA3 CD28
7 negative regulation of T cell proliferation GO:0042130 9.61 PDCD1LG2 CTLA4 CD274
8 positive regulation of interleukin-4 production GO:0032753 9.59 GATA3 CD28
9 negative regulation of interleukin-10 production GO:0032693 9.58 PDCD1LG2 CD274
10 leukocyte tethering or rolling GO:0050901 9.58 VCAM1 MADCAM1
11 negative regulation of interferon-gamma production GO:0032689 9.58 PDCD1LG2 GATA3 CD274
12 negative regulation of activated T cell proliferation GO:0046007 9.57 PDCD1LG2 CD274
13 regulation of regulatory T cell differentiation GO:0045589 9.56 CTLA4 CD28
14 regulation of immune response GO:0050776 9.55 VCAM1 TBX21 PDCD1 MADCAM1 CD276
15 negative regulation of immune response GO:0050777 9.54 PDCD1 CTLA4
16 regulation of T cell proliferation GO:0042129 9.52 CTLA4 CD28
17 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 TBX21 CD28
18 lymphocyte migration GO:0072676 9.46 TBX21 GATA3
19 positive regulation of T cell proliferation GO:0042102 9.35 VCAM1 PDCD1LG2 CD28 CD276 CD274
20 T cell costimulation GO:0031295 9.1 TNFRSF14 PDCD1LG2 PDCD1 CTLA4 CD28 CD274

Sources for Type 1 Diabetes Mellitus 21

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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