T1D23
MCID: TYP056
MIFTS: 30

Type 1 Diabetes Mellitus 23 (T1D23)

Categories: Endocrine diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 23

MalaCards integrated aliases for Type 1 Diabetes Mellitus 23:

Name: Type 1 Diabetes Mellitus 23 57 12 15
Diabetes Mellitus, Insulin-Dependent, 23 57 13 70
Iddm23 57 12
Diabetes Mellitus, Insulin-Dependent, 23; Iddm23 57
Insulin-Dependent Diabetes Mellitus 23 12
T1d23 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0110760
OMIM® 57 612622
ICD10 32 E10
MedGen 41 C2675472
UMLS 70 C2675472

Summaries for Type 1 Diabetes Mellitus 23

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 4q27.

MalaCards based summary : Type 1 Diabetes Mellitus 23, also known as diabetes mellitus, insulin-dependent, 23, is related to diabetes mellitus and subacute lymphocytic thyroiditis. An important gene associated with Type 1 Diabetes Mellitus 23 is IDDM23 (Diabetes Mellitus, Insulin-Dependent, 23), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include bone.

More information from OMIM: 612622

Related Diseases for Type 1 Diabetes Mellitus 23

Diseases in the Diabetes Mellitus family:

Type 1 Diabetes Mellitus 2 Type 2 Diabetes Mellitus
Type 1 Diabetes Mellitus Type 1 Diabetes Mellitus 3
Type 1 Diabetes Mellitus 4 Type 1 Diabetes Mellitus 5
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 11 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 12 Type 2 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 17
Type 2 Diabetes Mellitus 3 Diabetes Mellitus, Congenital Autoimmune
Type 1 Diabetes Mellitus 18 Type 2 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 19 Type 1 Diabetes Mellitus 20
Type 1 Diabetes Mellitus 21 Type 1 Diabetes Mellitus 22
Type 1 Diabetes Mellitus 23 Type 1 Diabetes Mellitus 24
Type 2 Diabetes 5 Rare Diabetes Mellitus Type 1
Rare Diabetes Mellitus Type 2 Rare Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus 23 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 375)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus 29.9 TNF SELL INS IDDM23 CD4 AOC3
2 subacute lymphocytic thyroiditis 10.1 SELL CD4
3 scleredema adultorum 10.1 INS CD8A
4 cork-handlers' disease 10.1 CD8A CD4
5 necrotic uveal melanoma 10.1 CD8A CD4
6 early yaws 10.1 CD8A CD4
7 ventilation pneumonitis 10.1 CD8A CD4
8 diffuse infiltrative lymphocytosis syndrome 10.1 CD8A CD4
9 latent syphilis 10.1 CD8A CD4
10 autoimmune lymphoproliferative syndrome, type iia 10.1 CD8A CD4
11 parapsoriasis 10.1 CD8A CD4
12 gastroduodenitis 10.1 CD8A CD4
13 primary syphilis 10.1 CD8A CD4
14 norwegian scabies 10.1 CD8A CD4
15 bird fancier's lung 10.1 CD8A CD4
16 metal allergy 10.1 CD8A CD4
17 variola major 10.1 CD8A CD4
18 follicular mucinosis 10.1 CD8A CD4
19 spongiotic dermatitis 10.1 CD8A CD4
20 acute retinal necrosis syndrome 10.1 CD8A CD4
21 mediastinitis 10.1 INS CD4
22 cerebral lymphoma 10.1 CD8A CD4
23 invasive malignant thymoma 10.0 CD8A CD4
24 west nile encephalitis 10.0 CD8A CD4
25 exanthema subitum 10.0 CD8A CD4
26 immunodeficiency 36 10.0 CD8A CD4
27 secondary syphilis 10.0 CD8A CD4
28 glanders 10.0 CD8A CD4
29 external ear disease 10.0 INS CD4
30 oral hairy leukoplakia 10.0 CD8A CD4
31 esophageal candidiasis 10.0 CD8A CD4
32 diabetic angiopathy 10.0 INS AOC3
33 otitis externa 10.0 INS CD4
34 parotid disease 10.0 CD8A CD4
35 marasmus 10.0 INS CD4
36 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.0 CD8A CD4
37 ulcerative stomatitis 10.0 CD8A CD4
38 west nile fever 10.0 CD8A CD4
39 retinitis pigmentosa 46 10.0 CD8A CD4
40 bell's palsy 10.0 CD8A CD4
41 adenoid hypertrophy 10.0 CD8A CD4
42 nickel allergic contact dermatitis 10.0 CD8A CD4
43 kwashiorkor 10.0 INS CD4
44 monkeypox 10.0 CD8A CD4
45 parotitis 10.0 CD8A CD4
46 suppurative thyroiditis 10.0 INS CD4
47 immunodeficiency 43 10.0 CD8A CD4
48 dacryoadenitis 10.0 CD8A CD4
49 rhinosporidiosis 10.0 CD8A CD4
50 xerophthalmia 10.0 CD8A CD4

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 23:



Diseases related to Type 1 Diabetes Mellitus 23

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 23

Clinical features from OMIM®:

612622 (Updated 05-Apr-2021)

Drugs & Therapeutics for Type 1 Diabetes Mellitus 23

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 23

Genetic Tests for Type 1 Diabetes Mellitus 23

Anatomical Context for Type 1 Diabetes Mellitus 23

MalaCards organs/tissues related to Type 1 Diabetes Mellitus 23:

40
Bone

Publications for Type 1 Diabetes Mellitus 23

Articles related to Type 1 Diabetes Mellitus 23:

# Title Authors PMID Year
1
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. 57
18978792 2008
2
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. 57
17554260 2007
3
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 57
17554300 2007
4
Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes. 57
16775037 2006
5
Age and sex based genetic locus heterogeneity in type 1 diabetes. 57
10699054 2000
6
A genome-wide search for human type 1 diabetes susceptibility genes. 57
8072542 1994
7
Health-related quality of life in type 1 diabetic patients and influence of peripheral nerve involvement. 61
11731877 2001
8
The effect of pramlintide (amylin analogue) treatment on bone metabolism and bone density in patients with type 1 diabetes mellitus. 61
10494873 1999

Variations for Type 1 Diabetes Mellitus 23

Expression for Type 1 Diabetes Mellitus 23

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 23.

Pathways for Type 1 Diabetes Mellitus 23

GO Terms for Type 1 Diabetes Mellitus 23

Biological processes related to Type 1 Diabetes Mellitus 23 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cognition GO:0050890 9.37 TNF INS
2 T cell activation GO:0042110 9.32 CD8A CD4
3 positive regulation of nitric-oxide synthase activity GO:0051000 9.26 TNF INS
4 leukocyte tethering or rolling GO:0050901 9.16 TNF SELL
5 negative regulation of lipid catabolic process GO:0050995 8.96 TNF INS
6 regulation of protein secretion GO:0050708 8.62 TNF INS

Molecular functions related to Type 1 Diabetes Mellitus 23 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.96 CD8A CD4
2 protease binding GO:0002020 8.8 TNF SELL INS

Sources for Type 1 Diabetes Mellitus 23

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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