T1D24
MCID: TYP057
MIFTS: 25

Type 1 Diabetes Mellitus 24 (T1D24)

Categories: Endocrine diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 24

MalaCards integrated aliases for Type 1 Diabetes Mellitus 24:

Name: Type 1 Diabetes Mellitus 24 57 12 15
Diabetes Mellitus, Insulin-Dependent, 24 57 13
Iddm24 57 12
Diabetes Mellitus, Insulin-Dependent, 24; Iddm24 57
Insulin-Dependent Diabetes Mellitus 24 12
T1d24 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0110761
OMIM® 57 613006
ICD10 32 E10
MedGen 41 C2751697

Summaries for Type 1 Diabetes Mellitus 24

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 10q23.31.

MalaCards based summary : Type 1 Diabetes Mellitus 24, also known as diabetes mellitus, insulin-dependent, 24, is related to diabetes mellitus and type 1 diabetes mellitus 2. An important gene associated with Type 1 Diabetes Mellitus 24 is IDDM24 (Diabetes Mellitus, Insulin-Dependent, 24), and among its related pathways/superpathways are Malaria and African trypanosomiasis.

More information from OMIM: 613006

Related Diseases for Type 1 Diabetes Mellitus 24

Diseases in the Diabetes Mellitus family:

Type 1 Diabetes Mellitus 2 Type 2 Diabetes Mellitus
Type 1 Diabetes Mellitus Type 1 Diabetes Mellitus 3
Type 1 Diabetes Mellitus 4 Type 1 Diabetes Mellitus 5
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 11 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 12 Type 2 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 17
Type 2 Diabetes Mellitus 3 Diabetes Mellitus, Congenital Autoimmune
Type 1 Diabetes Mellitus 18 Type 2 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 19 Type 1 Diabetes Mellitus 20
Type 1 Diabetes Mellitus 21 Type 1 Diabetes Mellitus 22
Type 1 Diabetes Mellitus 23 Type 1 Diabetes Mellitus 24
Type 2 Diabetes 5 Rare Diabetes Mellitus Type 1
Rare Diabetes Mellitus Type 2 Rare Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus 24 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus 29.8 TLR3 LTA IFIH1 IDDM24 HBA1 G6PC2
2 type 1 diabetes mellitus 2 10.2 GIMAP5 G6PC2
3 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.2 HBA2 HBA1
4 glutathione peroxidase deficiency 10.2 HBA2 HBA1
5 immune hydrops fetalis 10.2 HBA2 HBA1
6 alpha thalassemia-intellectual disability syndrome type 1 10.1 HBA2 HBA1
7 erythrocytosis, familial, 7 10.1 HBA2 HBA1
8 methemoglobinemia, beta-globin type 10.1 HBA2 HBA1
9 hypoglycemic coma 10.1 HBA2 HBA1
10 hypochromic microcytic anemia 10.1 HBA2 HBA1
11 hydrops fetalis, nonimmune 10.1 HBA2 HBA1
12 type 1 diabetes mellitus 18 10.1 MAS1L IFIH1
13 splenomegaly 10.1 HBA2 HBA1
14 type 1 diabetes mellitus 4 10.0 TLR3 GIMAP5
15 heinz body anemias 9.9 HBA2 HBA1
16 herpangina 9.8 TLR3 IFIH1
17 subacute sclerosing panencephalitis 9.7 TLR3 IFIH1
18 microphthalmia with limb anomalies 9.6 TLR3 IFIH1
19 type 1 diabetes mellitus 20 9.1 TLR3 MAS1L LTA IFIH1 DACT1

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 24:



Diseases related to Type 1 Diabetes Mellitus 24

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 24

Clinical features from OMIM®:

613006 (Updated 05-Mar-2021)

Drugs & Therapeutics for Type 1 Diabetes Mellitus 24

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 24

Genetic Tests for Type 1 Diabetes Mellitus 24

Anatomical Context for Type 1 Diabetes Mellitus 24

Publications for Type 1 Diabetes Mellitus 24

Articles related to Type 1 Diabetes Mellitus 24:

# Title Authors PMID Year
1
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 57
19430480 2009
2
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. 57
18978792 2008
3
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 57
17554300 2007
4
A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes. 61
17389329 2007

Variations for Type 1 Diabetes Mellitus 24

Expression for Type 1 Diabetes Mellitus 24

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 24.

Pathways for Type 1 Diabetes Mellitus 24

Pathways related to Type 1 Diabetes Mellitus 24 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.85 HBA2 HBA1
2 10.52 HBA2 HBA1
3
Show member pathways
10.17 HBA2 HBA1

GO Terms for Type 1 Diabetes Mellitus 24

Cellular components related to Type 1 Diabetes Mellitus 24 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosolic small ribosomal subunit GO:0022627 9.26 HBA2 HBA1
2 endocytic vesicle lumen GO:0071682 9.16 HBA2 HBA1
3 hemoglobin complex GO:0005833 8.96 HBA2 HBA1
4 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA2 HBA1

Biological processes related to Type 1 Diabetes Mellitus 24 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bicarbonate transport GO:0015701 9.43 HBA2 HBA1
2 positive regulation of interferon-beta production GO:0032728 9.4 TLR3 IFIH1
3 hydrogen peroxide catabolic process GO:0042744 9.37 HBA2 HBA1
4 positive regulation of interferon-alpha production GO:0032727 9.32 TLR3 IFIH1
5 cellular response to exogenous dsRNA GO:0071360 9.26 TLR3 IFIH1
6 oxygen transport GO:0015671 9.16 HBA2 HBA1
7 positive regulation of interleukin-6 production GO:0032755 9.13 TLR3 NLRP10 IFIH1
8 detection of virus GO:0009597 8.62 TLR3 IFIH1

Molecular functions related to Type 1 Diabetes Mellitus 24 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 9.32 HBA2 HBA1
2 oxygen binding GO:0019825 9.26 HBA2 HBA1
3 oxygen carrier activity GO:0005344 9.16 HBA2 HBA1
4 organic acid binding GO:0043177 8.96 HBA2 HBA1
5 haptoglobin binding GO:0031720 8.62 HBA2 HBA1

Sources for Type 1 Diabetes Mellitus 24

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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