T1D3
MCID: TYP029
MIFTS: 24

Type 1 Diabetes Mellitus 3 (T1D3)

Categories: Endocrine diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 3

MalaCards integrated aliases for Type 1 Diabetes Mellitus 3:

Name: Type 1 Diabetes Mellitus 3 57 12 15
Diabetes Mellitus, Insulin-Dependent, 3 57 13 70
Insulin-Dependent Diabetes Mellitus 3 57 12
Iddm3 57 12
Diabetes Mellitus, Insulin-Dependent, 3; Iddm3 57
T1d3 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0110742
OMIM® 57 600318
ICD10 32 E10
MedGen 41 C1838262
UMLS 70 C1838262

Summaries for Type 1 Diabetes Mellitus 3

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 15q26.

MalaCards based summary : Type 1 Diabetes Mellitus 3, also known as diabetes mellitus, insulin-dependent, 3, is related to type 1 diabetes mellitus and diabetes mellitus. An important gene associated with Type 1 Diabetes Mellitus 3 is IDDM3 (Insulin Dependent Diabetes Mellitus 3), and among its related pathways/superpathways is Platinum drug resistance.

More information from OMIM: 600318

Related Diseases for Type 1 Diabetes Mellitus 3

Diseases in the Diabetes Mellitus family:

Type 1 Diabetes Mellitus 2 Type 2 Diabetes Mellitus
Type 1 Diabetes Mellitus Type 1 Diabetes Mellitus 3
Type 1 Diabetes Mellitus 4 Type 1 Diabetes Mellitus 5
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 11 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 12 Type 2 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 17
Type 2 Diabetes Mellitus 3 Diabetes Mellitus, Congenital Autoimmune
Type 1 Diabetes Mellitus 18 Type 2 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 19 Type 1 Diabetes Mellitus 20
Type 1 Diabetes Mellitus 21 Type 1 Diabetes Mellitus 22
Type 1 Diabetes Mellitus 23 Type 1 Diabetes Mellitus 24
Type 2 Diabetes 5 Rare Diabetes Mellitus Type 1
Rare Diabetes Mellitus Type 2 Rare Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 type 1 diabetes mellitus 29.2 SLC30A8 SLC30A10 PTPN22 IL2RA
2 diabetes mellitus 11.1
3 adrenal cortical hypofunction 10.0 SLC30A10 PTPN22
4 barrett's adenocarcinoma 10.0 GSTM5 GSTM2
5 severe combined immunodeficiency 9.9
6 rheumatoid factor-negative polyarticular juvenile idiopathic arthritis 9.9 PTPN22 IL2RA
7 hirata disease 9.9 SLC30A8 SLC30A10
8 type 1 diabetes mellitus 18 9.9 PTPN22 IL2RA
9 oligoarticular juvenile idiopathic arthritis 9.9 PTPN22 IL2RA
10 immunodeficiency 31c 9.9 PTPN22 IL2RA
11 diabetes mellitus, ketosis-prone 9.9 SLC30A8 SLC30A10
12 type 1 diabetes mellitus 2 9.8 PTPN22 IL2RA
13 pancreatic cystadenoma 9.8 SLC30A8 SLC30A10
14 brachydactyly, type c 9.8 SLC30A8 SLC30A10
15 autoimmune disease of endocrine system 9.7 PTPN22 IL2RA
16 vogt-koyanagi-harada disease 9.7 PTPN22 IL2RA
17 gastrointestinal system benign neoplasm 9.6 SLC30A8 SLC30A10
18 celiac disease 1 9.3 SLC30A8 SLC30A10 PTPN22 IL2RA

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 3:



Diseases related to Type 1 Diabetes Mellitus 3

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 3

Clinical features from OMIM®:

600318 (Updated 05-Apr-2021)

Drugs & Therapeutics for Type 1 Diabetes Mellitus 3

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 3

Genetic Tests for Type 1 Diabetes Mellitus 3

Anatomical Context for Type 1 Diabetes Mellitus 3

Publications for Type 1 Diabetes Mellitus 3

Articles related to Type 1 Diabetes Mellitus 3:

# Title Authors PMID Year
1
Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27. 57
7573053 1995
2
A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus. 57
7842018 1994
3
[Cardiovascular autonomic neuropathy and nephropathy in patients with type-1 diabetes mellitus]. 61
15518324 2004

Variations for Type 1 Diabetes Mellitus 3

Expression for Type 1 Diabetes Mellitus 3

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 3.

Pathways for Type 1 Diabetes Mellitus 3

Pathways related to Type 1 Diabetes Mellitus 3 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.49 GSTM5 GSTM2

GO Terms for Type 1 Diabetes Mellitus 3

Cellular components related to Type 1 Diabetes Mellitus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intercellular bridge GO:0045171 8.62 GSTM5 GSTM2

Biological processes related to Type 1 Diabetes Mellitus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.48 SELENOS GSTM2
2 negative regulation of tumor necrosis factor production GO:0032720 9.46 SELENOS PTPN22
3 cation transport GO:0006812 9.43 SLC30A8 SLC30A10
4 negative regulation of interleukin-6 production GO:0032715 9.4 SELENOS PTPN22
5 response to glucose GO:0009749 9.37 SLC30A8 SELENOS
6 glutathione metabolic process GO:0006749 9.32 GSTM5 GSTM2
7 cellular zinc ion homeostasis GO:0006882 9.26 SLC30A8 SLC30A10
8 zinc ion transport GO:0006829 9.16 SLC30A8 SLC30A10
9 glutathione derivative biosynthetic process GO:1901687 8.96 GSTM5 GSTM2
10 zinc ion transmembrane transport GO:0071577 8.62 SLC30A8 SLC30A10

Molecular functions related to Type 1 Diabetes Mellitus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 9.16 GSTM5 GSTM2
2 zinc ion transmembrane transporter activity GO:0005385 8.96 SLC30A8 SLC30A10
3 cation transmembrane transporter activity GO:0008324 8.62 SLC30A8 SLC30A10

Sources for Type 1 Diabetes Mellitus 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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