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IDDM5
MCID: TYP031
MIFTS: 26

Type 1 Diabetes Mellitus 5 (IDDM5)

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Type 1 Diabetes Mellitus 5

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MalaCards integrated aliases for Type 1 Diabetes Mellitus 5:

Name: Type 1 Diabetes Mellitus 5 12 15
Diabetes Mellitus, Insulin-Dependent, 5 72
Insulin-Dependent Diabetes Mellitus 5 12
Iddm5 12

Classifications:

MalaCards categories:
Global: Metabolic diseases Rare diseases Genetic diseases
Anatomical: Endocrine diseases Reproductive diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:0110744
ICD10 33 E10
UMLS 72 C1838260
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Summaries for Type 1 Diabetes Mellitus 5

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Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the SUMO4 gene on chromosome 6q25.1.

MalaCards based summary : Type 1 Diabetes Mellitus 5, also known as diabetes mellitus, insulin-dependent, 5, is related to diabetes mellitus, insulin-dependent, 5 and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Type 1 Diabetes Mellitus 5 is SUMO4 (Small Ubiquitin Like Modifier 4), and among its related pathways/superpathways are TNFR1 Pathway and NF-kappaB Signaling. Affiliated tissues include heart, and related phenotypes are immune system and mortality/aging

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Related Diseases for Type 1 Diabetes Mellitus 5

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Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18 Rare Diabetes Mellitus Type 1
Rare Diabetes Mellitus Type 2 Rare Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent, 5 33.7 TAB2 SUMO4
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.2 INS CTLA4 AIRE
3 diabetes mellitus, insulin-dependent 29.9 TAB2 SUMO4 INS CTLA4 AIRE
4 type 1 diabetes mellitus 7 29.2 INS HBA2 HBA1
5 type 1 diabetes mellitus 18 10.5 TNFRSF25 TNFRSF10A
6 type 1 diabetes mellitus 15 10.5 INS HCCS
7 hirata disease 10.3 TNFRSF10A INS
8 type 1 diabetes mellitus 3 10.3 HCCS BBX
9 autoimmune addison disease 10.3 CTLA4 AIRE
10 type 1 diabetes mellitus 13 10.3 INS CTLA4
11 autoimmune disease of gastrointestinal tract 10.3 TNFRSF25 TNFRSF10A CTLA4
12 type 1 diabetes mellitus 2 10.3 TNFRSF25 INS FGF3
13 diabetes mellitus, insulin-dependent, 3 10.3
14 diabetes mellitus, insulin-dependent, 4 10.3
15 diabetes mellitus, insulin-dependent, 8 10.3
16 herpangina 10.2 TNFRSF25 TNFRSF10A
17 type 1 diabetes mellitus 17 10.2 TNFRSF25 CTLA4 AIRE
18 rheumatoid arthritis 10.1
19 diabetes mellitus, insulin-dependent, 7 10.1
20 diabetes mellitus, insulin-dependent, 17 10.1
21 juvenile rheumatoid arthritis 10.1
22 diabetes mellitus 10.1
23 type 1 diabetes mellitus 12 10.1 SUMO4 INS FGF3 CTLA4
24 cholangitis, primary sclerosing 10.1 TNFRSF25 FUT2 AIRE
25 chorioangioma 10.0 HBA1 CTLA4
26 diabetic polyneuropathy 10.0
27 polyneuropathy 10.0
28 pernicious anemia 9.9 FUT2 AIRE
29 type 1 diabetes mellitus 6 9.8 NPL INS HCCS FUT2
30 adrenal cortical hypofunction 9.8 TNFRSF25 AIRE
31 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 9.7 HBA2 HBA1
32 background diabetic retinopathy 9.7 INS HBA2
33 methemoglobinemia, beta-globin type 9.7 HBA2 HBA1
34 diabetes mellitus, insulin-dependent, 24 9.7 HBA2 HBA1
35 diabetic autonomic neuropathy 9.7 INS HBA2
36 hydrops fetalis, nonimmune 9.7 HBA2 HBA1
37 hydrops fetalis 9.7 HBA2 HBA1
38 type 1 diabetes mellitus 10 9.7 TNFRSF10A NPL HCCS FUT2 CTLA4
39 glutathione peroxidase deficiency 9.6 HBA2 HBA1
40 erythrocytosis, familial, 7 9.6 HBA2 HBA1
41 heinz body anemias 9.6 HBA2 HBA1
42 immature cataract 9.6 HBA2 HBA1
43 autoimmune disease of endocrine system 9.5 TNFRSF25 TNFRSF10A INS CTLA4 AIRE
44 hypoglycemic coma 9.4 INS HBA2 HBA1
45 retinal vascular disease 9.4 INS HBA2 HBA1
46 glucose metabolism disease 9.1 TNFRSF25 INS HBA2 HBA1
47 type 1 diabetes mellitus 11 8.9 TNFRSF25 INS HBA2 HBA1 CTLA4

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 5:



Diseases related to Type 1 Diabetes Mellitus 5
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Symptoms & Phenotypes for Type 1 Diabetes Mellitus 5

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MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 5:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 AIRE BBX CTLA4 FGF3 FUT2 INS
2 mortality/aging MP:0010768 9.36 AIRE CTLA4 FGF3 HBA2 HCCS INS
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Drugs & Therapeutics for Type 1 Diabetes Mellitus 5

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Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 5

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Genetic Tests for Type 1 Diabetes Mellitus 5

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Anatomical Context for Type 1 Diabetes Mellitus 5

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MalaCards organs/tissues related to Type 1 Diabetes Mellitus 5:

41
Heart
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Publications for Type 1 Diabetes Mellitus 5

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Articles related to Type 1 Diabetes Mellitus 5:

# Title Authors PMID Year
1
Insulin pump therapy: impact on the lives of children/young people with diabetes mellitus and their parents. 38
25108411 2014
2
Metabolic control in children with insulin-dependent diabetes mellitus 5 y after diagnosis. Early detection of patients at risk for poor metabolic control. 38
9736234 1998
3
Results of heart transplantation by extending recipient selection criteria. 38
7995827 1994
4
Visceral afferent neuropathy in diabetic gastroparesis. 38
1797493 1991
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Variations for Type 1 Diabetes Mellitus 5

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Expression for Type 1 Diabetes Mellitus 5

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Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 5.
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Pathways for Type 1 Diabetes Mellitus 5

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Pathways related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
TNFR1 Pathway 64
Show member pathways
 12.34 TNFRSF25 TNFRSF10A TAB2 SUMO1 NFKBIA
2
NF-kappaB Signaling 4
11.77 TNFRSF25 TAB2 NFKBIA CTLA4
3
NF-kB (NFkB) Pathway 67
10.66 SUMO4 SUMO1 NFKBIA
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GO Terms for Type 1 Diabetes Mellitus 5

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Cellular components related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 9.16 HBA2 HBA1
2 hemoglobin complex GO:0005833 8.96 HBA2 HBA1
3 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA2 HBA1

Biological processes related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cellular protein metabolic process GO:0032270 8.96 NFKBIA INS
2 oxygen transport GO:0015671 8.62 HBA2 HBA1

Molecular functions related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen carrier activity GO:0005344 9.26 HBA2 HBA1
2 protein tag GO:0031386 9.16 SUMO4 SUMO1
3 organic acid binding GO:0043177 8.96 HBA2 HBA1
4 haptoglobin binding GO:0031720 8.62 HBA2 HBA1
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Sources for Type 1 Diabetes Mellitus 5

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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