IDDM5
MCID: TYP031
MIFTS: 25

Type 1 Diabetes Mellitus 5 (IDDM5)

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 5

MalaCards integrated aliases for Type 1 Diabetes Mellitus 5:

Name: Type 1 Diabetes Mellitus 5 12 15
Diabetes Mellitus, Insulin-Dependent, 5 74
Insulin-Dependent Diabetes Mellitus 5 12
Iddm5 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110744
ICD10 34 E10
UMLS 74 C1838260

Summaries for Type 1 Diabetes Mellitus 5

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the SUMO4 gene on chromosome 6q25.1.

MalaCards based summary : Type 1 Diabetes Mellitus 5, also known as diabetes mellitus, insulin-dependent, 5, is related to diabetes mellitus, insulin-dependent, 5 and type 1 diabetes mellitus 15. An important gene associated with Type 1 Diabetes Mellitus 5 is SUMO4 (Small Ubiquitin Like Modifier 4), and among its related pathways/superpathways are NF-kappaB Signaling and NF-kB (NFkB) Pathway. Related phenotypes are no effect and immune system

Related Diseases for Type 1 Diabetes Mellitus 5

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent, 5 32.5 SUMO4 TAB2
2 type 1 diabetes mellitus 15 10.3 HCCS INS
3 autoimmune addison disease 10.2 AIRE CTLA4
4 autoimmune disease of gastrointestinal tract 10.2 CTLA4 TNFRSF10A TNFRSF25
5 hirata disease 10.2 INS TNFRSF10A
6 type 1 diabetes mellitus 2 10.2 FGF3 INS TNFRSF25
7 type 1 diabetes mellitus 13 10.2 CTLA4 INS
8 type 1 diabetes mellitus 17 10.1 AIRE CTLA4 TNFRSF25
9 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.1 HBA1 HBA2
10 rheumatoid arthritis 10.1
11 arthritis 10.1
12 diabetes mellitus 10.1
13 methemoglobinemia, beta-globin type 10.1 HBA1 HBA2
14 herpangina 10.1 TNFRSF10A TNFRSF25
15 diabetes mellitus, insulin-dependent, 24 10.1 HBA1 HBA2
16 cholangitis, primary sclerosing 10.1 AIRE FUT2 TNFRSF25
17 chorioangioma 10.1 CTLA4 HBA1
18 type 1 diabetes mellitus 12 10.1 CTLA4 FGF3 INS SUMO4
19 type 1 diabetes mellitus 18 10.1 TNFRSF10A LAD1 TNFRSF25
20 hydrops fetalis, nonimmune 10.1 HBA1 HBA2
21 hydrops fetalis 10.1 HBA1 HBA2
22 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 AIRE CTLA4 INS
23 glutathione peroxidase deficiency 10.0 HBA1 HBA2
24 pernicious anemia 10.0 AIRE FUT2
25 heinz body anemias 10.0 HBA1 HBA2
26 erythrocytosis, familial, 7 10.0 HBA1 HBA2
27 background diabetic retinopathy 10.0 HBA2 INS
28 type 1 diabetes mellitus 3 10.0 BBX HCCS
29 immature cataract 10.0 HBA1 HBA2
30 type 1 diabetes mellitus 6 9.9 NPL INS HCCS FUT2
31 hypoglycemic coma 9.9 HBA1 HBA2 INS
32 type 1 diabetes mellitus 7 9.9 HBA1 HBA2 INS
33 retinal vascular disease 9.9 HBA1 HBA2 INS
34 type 1 diabetes mellitus 10 9.9 CTLA4 FUT2 HCCS NPL TNFRSF10A
35 diabetes mellitus, insulin-dependent 9.8 AIRE CTLA4 INS SUMO4 TAB2
36 autoimmune disease of endocrine system 9.8 AIRE CTLA4 INS TNFRSF10A TNFRSF25
37 diabetic autonomic neuropathy 9.8 HBA2 INS
38 type 1 diabetes mellitus 11 9.6 CTLA4 HBA1 HBA2 INS TNFRSF25
39 glucose metabolism disease 9.4 HBA1 TNFRSF25 LAD1 INS HBA2

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 5:



Diseases related to Type 1 Diabetes Mellitus 5

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 5

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.9 AIRE BBX CTLA4 FGF3 FUT2 HBA1

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 5:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.32 AIRE BBX CTLA4 FUT2 INS NFKBIA

Drugs & Therapeutics for Type 1 Diabetes Mellitus 5

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 5

Genetic Tests for Type 1 Diabetes Mellitus 5

Anatomical Context for Type 1 Diabetes Mellitus 5

Publications for Type 1 Diabetes Mellitus 5

Variations for Type 1 Diabetes Mellitus 5

Expression for Type 1 Diabetes Mellitus 5

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 5.

Pathways for Type 1 Diabetes Mellitus 5

Pathways related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 CTLA4 NFKBIA TAB2 TNFRSF25
2 10.66 NFKBIA SUMO1 SUMO4

GO Terms for Type 1 Diabetes Mellitus 5

Cellular components related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
2 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
3 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cellular protein metabolic process GO:0032270 8.96 INS NFKBIA
2 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen carrier activity GO:0005344 9.26 HBA1 HBA2
2 organic acid binding GO:0043177 9.16 HBA1 HBA2
3 protein tag GO:0031386 8.96 SUMO1 SUMO4
4 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Type 1 Diabetes Mellitus 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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