IDDM5
MCID: TYP031
MIFTS: 25

Type 1 Diabetes Mellitus 5 (IDDM5)

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 5

MalaCards integrated aliases for Type 1 Diabetes Mellitus 5:

Name: Type 1 Diabetes Mellitus 5 12 15
Diabetes Mellitus, Insulin-Dependent, 5 73
Insulin-Dependent Diabetes Mellitus 5 12
Iddm5 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110744
ICD10 33 E10
UMLS 73 C1838260

Summaries for Type 1 Diabetes Mellitus 5

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the SUMO4 gene on chromosome 6q25.1.

MalaCards based summary : Type 1 Diabetes Mellitus 5, also known as diabetes mellitus, insulin-dependent, 5, is related to diabetes mellitus, insulin-dependent, 5 and type 1 diabetes mellitus 15. An important gene associated with Type 1 Diabetes Mellitus 5 is SUMO4 (Small Ubiquitin-Like Modifier 4), and among its related pathways/superpathways are TNFR1 Pathway and TRAF Pathway. Affiliated tissues include t cells, and related phenotypes are immune system and mortality/aging

Related Diseases for Type 1 Diabetes Mellitus 5

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent, 5 32.2 TAB2 SUMO4
2 type 1 diabetes mellitus 15 10.2 INS HCCS
3 type 1 diabetes mellitus 13 10.2 CTLA4 INS
4 hirata disease 10.2 TNFRSF10A INS
5 autoimmune addison disease 10.1 CTLA4 AIRE
6 herpangina 10.1 TNFRSF10A TNFRSF25
7 type 1 diabetes mellitus 2 10.1 TNFRSF25 INS FGF3
8 autoimmune disease of gastrointestinal tract 10.1 TNFRSF25 TNFRSF10A CTLA4
9 neuroretinitis 10.1 CTLA4 TNFRSF10A
10 hypoglycemic coma 10.1 INS HBA2
11 type 1 diabetes mellitus 7 10.1 INS HBA2
12 celiac disease 1 10.1 TNFRSF25 TNFRSF10A CTLA4
13 rheumatoid arthritis 10.1
14 arthritis 10.1
15 diabetes mellitus 10.1
16 pernicious anemia 10.1 AIRE FUT2
17 type 1 diabetes mellitus 17 10.1 TNFRSF25 CTLA4 AIRE
18 type 1 diabetes mellitus 12 10.1 SUMO4 INS FGF3 CTLA4
19 background diabetic retinopathy 10.1 HBA2 INS
20 adrenal cortical hypofunction 10.0 AIRE TNFRSF25
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 INS CTLA4 AIRE
22 diabetic autonomic neuropathy 10.0 HBA2 INS
23 type 1 diabetes mellitus 18 10.0 TNFRSF25 TNFRSF10A LAD1
24 cholangitis, primary sclerosing 10.0 TNFRSF25 FUT2 AIRE
25 type 1 diabetes mellitus 3 10.0 HCCS BBX
26 maturity-onset diabetes of the young, type 13 9.9 INS LAD1
27 immune system disease 9.9 TNFRSF25 TNFRSF10A CTLA4 AIRE
28 type 1 diabetes mellitus 6 9.9 NPL INS HCCS FUT2
29 type 1 diabetes mellitus 11 9.9 TNFRSF25 INS HBA2 CTLA4
30 autonomic nervous system disease 9.9 HBA2 INS
31 type 1 diabetes mellitus 10 9.9 TNFRSF10A NPL HCCS FUT2 CTLA4
32 autoimmune disease of endocrine system 9.8 TNFRSF25 TNFRSF10A INS CTLA4 AIRE
33 glucose metabolism disease 9.8 TNFRSF25 LAD1 INS HBA2
34 diabetes mellitus, insulin-dependent 9.7 TNFRSF25 TNFRSF10A TAB2 SUMO4 INS CTLA4

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 5:



Diseases related to Type 1 Diabetes Mellitus 5

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 5

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 5:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 AIRE BBX CTLA4 FGF3 FUT2 INS
2 mortality/aging MP:0010768 9.36 AIRE CTLA4 FGF3 HBA2 HCCS INS

Drugs & Therapeutics for Type 1 Diabetes Mellitus 5

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 5

Genetic Tests for Type 1 Diabetes Mellitus 5

Anatomical Context for Type 1 Diabetes Mellitus 5

MalaCards organs/tissues related to Type 1 Diabetes Mellitus 5:

41
T Cells

Publications for Type 1 Diabetes Mellitus 5

Variations for Type 1 Diabetes Mellitus 5

Expression for Type 1 Diabetes Mellitus 5

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 5.

Pathways for Type 1 Diabetes Mellitus 5

GO Terms for Type 1 Diabetes Mellitus 5

Biological processes related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cellular protein metabolic process GO:0032270 8.62 INS NFKBIA

Molecular functions related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tag GO:0031386 8.62 SUMO1 SUMO4

Sources for Type 1 Diabetes Mellitus 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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