Type 1 Diabetes Mellitus 5 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Type 1 Diabetes Mellitus 5

MalaCards integrated aliases for Type 1 Diabetes Mellitus 5:

Name: Type 1 Diabetes Mellitus 5 ¹² ¹⁵

Diabetes Mellitus, Insulin-Dependent, 5 ⁷⁴

Insulin-Dependent Diabetes Mellitus 5 ¹²

Iddm5 ¹²

Classifications:

MalaCards categories:
Global: Metabolic diseases Genetic diseases
Anatomical: Endocrine diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Endocrine, nutritional and metabolic diseases

Diabetes mellitus

Insulin-dependent diabetes mellitus

External Ids:

Disease Ontology ¹² DOID:0110744

ICD10 ³⁴ E10

UMLS ⁷⁴ C1838260

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Summaries for Type 1 Diabetes Mellitus 5

Disease Ontology : ¹² A type 1 diabetes mellitus that has material basis in mutation of the SUMO4 gene on chromosome 6q25.1.

MalaCards based summary : Type 1 Diabetes Mellitus 5, also known as diabetes mellitus, insulin-dependent, 5, is related to diabetes mellitus, insulin-dependent, 5 and diabetes mellitus, insulin-dependent. An important gene associated with Type 1 Diabetes Mellitus 5 is SUMO4 (Small Ubiquitin Like Modifier 4), and among its related pathways/superpathways are NF-kappaB Signaling and NF-kB (NFkB) Pathway. Affiliated tissues include t cells, and related phenotypes are no effect and immune system

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Related Diseases for Type 1 Diabetes Mellitus 5

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune	Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3	Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5	Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7	Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10	Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12	Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15	Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)

#	Related Disease	Score	Top Affiliating Genes
1	diabetes mellitus, insulin-dependent, 5	33.2	SUMO4 TAB2
2	diabetes mellitus, insulin-dependent	29.8	AIRE CTLA4 INS SUMO4 TAB2
3	type 1 diabetes mellitus 15	10.3	HCCS INS
4	autoimmune addison disease	10.2	AIRE CTLA4
5	autoimmune disease of gastrointestinal tract	10.2	CTLA4 TNFRSF10A TNFRSF25
6	hirata disease	10.2	INS TNFRSF10A
7	type 1 diabetes mellitus 2	10.2	FGF3 INS TNFRSF25
8	diabetes mellitus, insulin-dependent, 4	10.2
9	diabetes mellitus, insulin-dependent, 8	10.2
10	type 1 diabetes mellitus 13	10.2	CTLA4 INS
11	type 1 diabetes mellitus 17	10.1	AIRE CTLA4 TNFRSF25
12	alpha-thalassemia/mental retardation syndrome, chromosome 16-related	10.1	HBA1 HBA2
13	methemoglobinemia, beta-globin type	10.1	HBA1 HBA2
14	herpangina	10.1	TNFRSF10A TNFRSF25
15	diabetes mellitus, insulin-dependent, 24	10.1	HBA1 HBA2
16	cholangitis, primary sclerosing	10.1	AIRE FUT2 TNFRSF25
17	chorioangioma	10.1	CTLA4 HBA1
18	type 1 diabetes mellitus 12	10.1	CTLA4 FGF3 INS SUMO4
19	type 1 diabetes mellitus 18	10.1	LAD1 TNFRSF10A TNFRSF25
20	hydrops fetalis, nonimmune	10.1	HBA1 HBA2
21	hydrops fetalis	10.1	HBA1 HBA2
22	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	10.1	AIRE CTLA4 INS
23	glutathione peroxidase deficiency	10.0	HBA1 HBA2
24	pernicious anemia	10.0	AIRE FUT2
25	heinz body anemias	10.0	HBA1 HBA2
26	rheumatoid arthritis	10.0
27	diabetes mellitus, insulin-dependent, 3	10.0
28	arthritis	10.0
29	diabetes mellitus	10.0
30	juvenile rheumatoid arthritis	10.0
31	erythrocytosis, familial, 7	10.0	HBA1 HBA2
32	background diabetic retinopathy	10.0	HBA2 INS
33	type 1 diabetes mellitus 3	10.0	BBX HCCS
34	immature cataract	10.0	HBA1 HBA2
35	type 1 diabetes mellitus 6	10.0	FUT2 HCCS INS NPL
36	hypoglycemic coma	9.9	HBA1 HBA2 INS
37	type 1 diabetes mellitus 7	9.9	HBA1 HBA2 INS
38	retinal vascular disease	9.9	HBA1 HBA2 INS
39	type 1 diabetes mellitus 10	9.9	CTLA4 FUT2 HCCS NPL TNFRSF10A
40	autoimmune disease of endocrine system	9.8	AIRE CTLA4 INS TNFRSF10A TNFRSF25
41	diabetic autonomic neuropathy	9.8	HBA2 INS
42	type 1 diabetes mellitus 11	9.6	CTLA4 HBA1 HBA2 INS TNFRSF25
43	glucose metabolism disease	9.5	HBA1 HBA2 INS LAD1 TNFRSF25

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 5:

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Symptoms & Phenotypes for Type 1 Diabetes Mellitus 5

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	9.9	AIRE BBX CTLA4 FGF3 FUT2 HBA1

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 5:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.36	AIRE BBX CTLA4 FGF3 FUT2 INS

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Drugs & Therapeutics for Type 1 Diabetes Mellitus 5

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 5

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Genetic Tests for Type 1 Diabetes Mellitus 5

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Anatomical Context for Type 1 Diabetes Mellitus 5

MalaCards organs/tissues related to Type 1 Diabetes Mellitus 5:

⁴²

T Cells

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Publications for Type 1 Diabetes Mellitus 5

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Genes for Type 1 Diabetes Mellitus 5

Genes related to Type 1 Diabetes Mellitus 5 (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SUMO4	Small Ubiquitin Like Modifier 4	Protein Coding	18.82	DISEASES inferred ¹⁵
2	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	16.77	DISEASES inferred ¹⁵
3	TULP4	TUB Like Protein 4	Protein Coding	16.52	DISEASES inferred ¹⁵
4	PCMT1	Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase	Protein Coding	15.95	DISEASES inferred ¹⁵
5	FGF3	Fibroblast Growth Factor 3	Protein Coding	15.63	DISEASES inferred ¹⁵
6	HCCS	Holocytochrome C Synthase	Protein Coding	14.76	DISEASES inferred ¹⁵
7	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	14.68	DISEASES inferred ¹⁵
8	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	14.53	DISEASES inferred ¹⁵
9	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	14.46	DISEASES inferred ¹⁵
10	FUT2	Fucosyltransferase 2	Protein Coding	14.28	DISEASES inferred ¹⁵
11	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	14.2	DISEASES inferred ¹⁵
12	NPL	N-Acetylneuraminate Pyruvate Lyase	Protein Coding	14.2	DISEASES inferred ¹⁵
13	INS	Insulin	Protein Coding	14.17	DISEASES inferred ¹⁵
14	AIRE	Autoimmune Regulator	Protein Coding	13.73	DISEASES inferred ¹⁵
15	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	13.47	DISEASES inferred ¹⁵
16	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	13.47	DISEASES inferred ¹⁵
17	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	13.37	DISEASES inferred ¹⁵
18	BBX	BBX High Mobility Group Box Domain Containing	Protein Coding	5.86	DISEASES inferred ¹⁵
19	LAD1	Ladinin 1	Protein Coding	5.03	DISEASES inferred ¹⁵

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Variations for Type 1 Diabetes Mellitus 5

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Expression for Type 1 Diabetes Mellitus 5

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 5.

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Pathways for Type 1 Diabetes Mellitus 5

Pathways related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ⁴	11.77	CTLA4 NFKBIA TAB2 TNFRSF25
2	NF-kB (NFkB) Pathway ⁶⁸	10.66	NFKBIA SUMO1 SUMO4

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GO Terms for Type 1 Diabetes Mellitus 5

Cellular components related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endocytic vesicle lumen	GO:0071682	9.16	HBA1 HBA2
2	hemoglobin complex	GO:0005833	8.96	HBA1 HBA2
3	haptoglobin-hemoglobin complex	GO:0031838	8.62	HBA1 HBA2

Biological processes related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cellular protein metabolic process	GO:0032270	8.96	INS NFKBIA
2	oxygen transport	GO:0015671	8.62	HBA1 HBA2

Molecular functions related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxygen carrier activity	GO:0005344	9.26	HBA1 HBA2
2	organic acid binding	GO:0043177	9.16	HBA1 HBA2
3	protein tag	GO:0031386	8.96	SUMO1 SUMO4
4	haptoglobin binding	GO:0031720	8.62	HBA1 HBA2

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Sources for Type 1 Diabetes Mellitus 5

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹⁶ DrugBank

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¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

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⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia