Type 1 Diabetes Mellitus 5 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

T1D5 MCID: TYP031 MIFTS: 48	Type 1 Diabetes Mellitus 5 (T1D5) Categories: Endocrine diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Drugs Expand all tables

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Aliases & Classifications for Type 1 Diabetes Mellitus 5

MalaCards integrated aliases for Type 1 Diabetes Mellitus 5:

Name: Type 1 Diabetes Mellitus 5 ⁵⁷ ¹¹ ²⁸ ⁵ ¹⁴

Latent Autoimmune Diabetes in Adults ¹¹ ⁴³ ¹⁴ ¹⁶ ⁷⁵

Diabetes Mellitus, Insulin-Dependent, 5 ⁵⁷ ⁷³ ¹² ⁷¹

Iddm5 ⁵⁷ ¹¹ ⁷³

Insulin-Dependent Diabetes Mellitus 5 ⁵⁷ ¹¹

Diabetes Mellitus, Insulin-Dependent, Type 5 ³⁸

Type 1.5 Diabetes ¹¹

T1d5 ⁵⁷

Lada ¹¹

Classifications:

MalaCards categories:
Global: Genetic diseases Metabolic diseases Rare diseases
Anatomical: Endocrine diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Endocrine, nutritional and metabolic diseases

Diabetes mellitus

Insulin-dependent diabetes mellitus

External Ids:

Disease Ontology ¹¹ DOID:0080846 DOID:0110744

OMIM® ⁵⁷ 600320

MeSH ⁴³ D000071698 D003922

ICD10 ³¹ E10

MedGen ⁴⁰ C1838260

EFO ¹⁶ EFO_0009706

UMLS ⁷¹ C1838260

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Summaries for Type 1 Diabetes Mellitus 5

UniProtKB/Swiss-Prot: ⁷³ A form of diabetes mellitus, a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

MalaCards based summary: Type 1 Diabetes Mellitus 5, also known as latent autoimmune diabetes in adults, is related to hypothyroidism and hashimoto thyroiditis. An important gene associated with Type 1 Diabetes Mellitus 5 is SUMO4 (Small Ubiquitin Like Modifier 4), and among its related pathways/superpathways are NF-kappaB Signaling and CD28 co-stimulation. The drugs Metformin and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include lymph node, pancreatic islet and thyroid, and related phenotypes are Increased apoptosis and homeostasis/metabolism

Disease Ontology ¹¹ Type 1 diabetes mellitus 5: A type 1 diabetes mellitus that has material basis in mutation of the SUMO4 gene on chromosome 6q25.1.

Latent autoimmune diabetes in adults: A type 1 diabetes mellitus that is characterized by a less intensive autoimmune process, highly variable β-cell destruction, different degrees of insulin resistance and heterogeneous titre and pattern of islet autoantibody, sharing features with both type 1 and type 2 diabetes mellitus.

Wikipedia: ⁷⁵ Slowly evolving immune-mediated diabetes, or latent autoimmune diabetes in adults (LADA), is a form of... more...

More information from OMIM: 600320

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Related Diseases for Type 1 Diabetes Mellitus 5

Diseases in the Diabetes Mellitus family:

Type 1 Diabetes Mellitus 2	Type 2 Diabetes Mellitus
Type 1 Diabetes Mellitus	Type 1 Diabetes Mellitus 3
Type 1 Diabetes Mellitus 4	Type 1 Diabetes Mellitus 5
Type 1 Diabetes Mellitus 7	Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 11	Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 12	Type 2 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 15	Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 10	Type 1 Diabetes Mellitus 17
Type 2 Diabetes Mellitus 3	Diabetes Mellitus, Congenital Autoimmune
Type 1 Diabetes Mellitus 18	Type 2 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 19	Type 1 Diabetes Mellitus 20
Type 1 Diabetes Mellitus 21	Type 1 Diabetes Mellitus 22
Type 1 Diabetes Mellitus 23	Type 1 Diabetes Mellitus 24
Type 2 Diabetes 5	Rare Diabetes Mellitus Type 1
Rare Diabetes Mellitus Type 2	Rare Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)

#	Related Disease	Score	Top Affiliating Genes
1	hypothyroidism	30.6	TG PTPN22 INS HLA-DQB1 CTLA4
2	hashimoto thyroiditis	30.5	TNFRSF25 TG PTPN22 GAD2 CTLA4
3	type 1 diabetes mellitus 3	30.5	SLC30A8 SLC30A10 INS
4	autoimmune polyendocrine syndrome	30.4	TG PTPN22 GAD2
5	vitiligo-associated multiple autoimmune disease susceptibility 1	30.3	TG PTPN22 CTLA4
6	diabetes mellitus, ketosis-prone	30.3	SLC30A8 SLC30A10 PTPRN INSM2 INS GAD2
7	insulinoma	30.3	SLC30A8 PTPRN2 PTPRN INSM2 INS CPE
8	thyroiditis	30.3	TNFRSF25 TG PTPN22 INS HLA-DQB1 HLA-DQA1
9	hirata disease	30.2	TNFRSF10A SLC30A8 SLC30A10 INS HLA-DQA1
10	juvenile rheumatoid arthritis	30.1	PTPN22 HLA-DQB1 HLA-DQA1
11	graves disease 1	30.0	TG INS
12	maturity-onset diabetes of the young	30.0	SLC30A8 SLC30A10 PTPRN INSM2 INS GAD2
13	autoimmune hepatitis	29.9	PTPN22 HLA-DQB1 CTLA4
14	pernicious anemia	29.8	TOR1A TNFRSF25 TG PTPRN PTPN22 INS
15	autoimmune disease	29.3	TG PTPRN PTPN22 INS HLA-DQB1 HLA-DQA1
16	type 1 diabetes mellitus	28.9	TNFRSF25 TG SUMO4 SLC30A10 PTPRN2 PTPRN
17	celiac disease 1	28.5	TOR1A TNFRSF25 TNFRSF10A TG SLC30A8 SLC30A10
18	diabetes mellitus	28.2	TNFRSF25 TG SUMO4 SLC30A8 SH2B3 PTPRN2
19	oto-palatal-digital syndrome	10.7
20	type 2 diabetes mellitus	10.7
21	abdominal obesity-metabolic syndrome 1	10.4
22	49, xxxxy syndrome	10.4
23	down syndrome	10.3
24	microvascular complications of diabetes 5	10.3
25	neuropathy	10.3
26	primary agammaglobulinemia	10.3
27	ulcer of lower limbs	10.3	TNFRSF10A INS
28	juvenile dermatitis herpetiformis	10.3	TNFRSF25 HLA-DQA1
29	adult-onset myasthenia gravis	10.3	HLA-DQA1 CTLA4
30	pemphigoid gestationis	10.3	TNFRSF25 TNFRSF10A
31	amelogenesis imperfecta, type ib	10.3	TNFRSF25 TNFRSF10A
32	podoconiosis	10.2	HLA-DQB1 HLA-DQA1
33	isthmus cancer	10.2	TG PTPRN
34	bleeding disorder, platelet-type, 17	10.2	PTPRN2 INSM2
35	chondromalacia	10.2	TNFRSF10A HLA-DQA1
36	alcohol dependence	10.2
37	erythermalgia, primary	10.2
38	oculodentodigital dysplasia	10.2
39	hypothyroidism, congenital, nongoitrous, 2	10.2
40	microvascular complications of diabetes 1	10.2
41	hypothyroidism, congenital, nongoitrous, 3	10.2
42	microvascular complications of diabetes 2	10.2
43	microvascular complications of diabetes 3	10.2
44	microvascular complications of diabetes 4	10.2
45	microvascular complications of diabetes 6	10.2
46	microvascular complications of diabetes 7	10.2
47	monocarboxylate transporter 1 deficiency	10.2
48	non-alcoholic fatty liver disease	10.2
49	rickets	10.2
50	prediabetes syndrome	10.2

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 5:

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Symptoms & Phenotypes for Type 1 Diabetes Mellitus 5

Clinical features from OMIM®:

600320 (Updated 08-Dec-2022)

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.18	CPE CTLA4 GAD2 HLA-DQA1 HLA-DQB1 INS
2	no effect	GR00402-S-2	10.18	CPE CTLA4 GAD2 HLA-DQA1 INS INSM2
3	Increased apoptosis	GR00093-A-0	9.13	PTPN22 PTPRN PTPRN2

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 5:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.1	CPE CTLA4 GAD2 HLA-DQB1 INS PTPN22
2	endocrine/exocrine gland	MP:0005379	10	CPE CTLA4 GAD2 HLA-DQA1 HLA-DQB1 INS
3	immune system	MP:0005387	9.8	CPE CTLA4 GAD2 HLA-DQA1 HLA-DQB1 INS
4	hematopoietic system	MP:0005397	9.44	CPE CTLA4 HLA-DQA1 HLA-DQB1 INS PTPN22

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Drugs & Therapeutics for Type 1 Diabetes Mellitus 5

Drugs for Type 1 Diabetes Mellitus 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Metformin

Approved

Phase 4

1115-70-4, 657-24-9

4091

Zinc cation

Approved, Experimental, Investigational

Phase 4

7440-66-6, 23713-49-7

32051

Saxagliptin

Approved

Phase 4

361442-04-8

11243969

Cholecalciferol

Approved, Nutraceutical, Vet_approved

Phase 4

67-97-0, 1406-16-2

5280795 10883523

Inulin

Approved, Investigational, Nutraceutical

Phase 4

9005-80-5

24763

Vitamins

Phase 4

Insulin, Globin Zinc

Phase 4

Insulin

Phase 4

Trace Elements

Phase 4

Calciferol

Phase 4

Micronutrients

Phase 4

Hypoglycemic Agents

Phase 4

Hormones

Phase 4

Hormone Antagonists

Phase 4

Calcium, Dietary

Phase 4

HIV Protease Inhibitors

Phase 4

Dipeptidyl-Peptidase IV Inhibitors

Phase 4

Incretins

Phase 4

protease inhibitors

Phase 4

Calcium

Nutraceutical

Phase 4

7440-70-2

271

Aluminum sulfate

Approved

Phase 2

10043-01-3

Aluminum hydroxide

Approved, Investigational

Phase 2

21645-51-2

Glutamic acid

Approved, Nutraceutical

Phase 2

56-86-0

33032

Anti-Ulcer Agents

Phase 2

Adjuvants, Immunologic

Phase 2

Antacids

Phase 2

Gastrointestinal Agents

Phase 2

Immunologic Factors

Phase 2

Sitagliptin Phosphate

Phase 1, Phase 2

654671-77-9

Insulin aspart

Approved

116094-23-6

16132418

Rosiglitazone

Approved, Investigational

122320-73-4, 155141-29-0

77999

Glyburide

Approved

10238-21-8

3488

Repaglinide

Approved, Investigational

135062-02-1

65981

Insulin aspart, insulin aspart protamine drug combination 30:70

Protamines

Autoantibodies

Insulin, Isophane

Isophane Insulin, Human

Isophane insulin, beef

Interventional clinical trials:

(show all 13)

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Controlled, Open-label, Multi-center Study With 104-week Saxagliptin or (and) Vitamin D3 Assessing Protective Effects on Beta Cell Function in Latent Autoimmune Diabetes in Adults (LADA) Treated With Metformin (and Insulin)	Completed	NCT02407899	Phase 4	Saxagliptin;Vitamin D3;Insulin;Metformin
2	Early Insulin Treatment in Patients With Latent Autoimmune Diabetes (LADA)	Completed	NCT01109927	Phase 4	Insulin
3	Effects of Berberine Plus Inulin on Diabetes Care in Patients With Latent Autoimmune Diabetes in Adults: A Randomized Controlled Trial	Not yet recruiting	NCT04698330	Phase 4	Berberine;Inulin;Berberine placebo tablets;Inulin placebo tablets
4	A Pilot Study on Safety, Feasibility and Insulin-promotion by Intra-inguinal Lymph Node Injections of Glutamic Acid Decarboxylase (GAD) in Patients With LADA Type of Diabetes	Completed	NCT04262479	Phase 2	recombinant human glutamic acid dehydrogenase (rhGAD65), formulated in aluminium hydrogel;Vitamin D
5	A Placebo-Controlled Study to Investigate the Impact of Diamyd® on the Diabetes Status of Patients With LADA (Latent Autoimmune Diabetes in Adult)	Completed	NCT00456027	Phase 2	rhGAD65 formulated in Alhydrogel® (Diamyd®)
6	Protective Effects of Sitagliptin on β Cell Function in Patients With Adult-onset Latent Autoimmune Diabetes (LADA)	Completed	NCT01159847	Phase 1, Phase 2	sitagliptin;Insulin
7	Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Investigate the Safety and Tolerability as Well as the Immunological and Clinical Efficacy of Multiple Subcutaneous Doses of DiaPep277 in LADA Subjects	Terminated	NCT00058981	Phase 2	DiaPep277
8	Randomized, Controlled, Parallel-Group Prospective Study to Investigate the Clinical Effectiveness of Early Insulin Treatment in Patients With Latent Autoimmune Diabetes in Adults	Unknown status	NCT00776607		NovoMix 30;Tablet treatment
9	Rosiglitazone Intervention Study in Patients With Type 1.5 Diabetes	Completed	NCT00194896		rosiglitazone;glyburide
10	A Study of the Genetic Causes of Latent Autoimmune Diabetes in Adults	Completed	NCT01793974
11	Detection of Latent Autoimmune Diabetes in Adults, Clinical and Metabolic Profile in Patients Treated at the Diabetes Clinic in a Hospital in the Mexican Southeast.	Completed	NCT05235672
12	Is "Beta Cell Rest" by Insulin Treatment Beneficial Compared to State-of-the Art Enhancers of Insulin Secretion in Preserving Beta Cell Function in Subjects With Latent Autoimmune Diabetes of the Adult (LADA)?	Completed	NCT01140438		metformin+ NPH insulin;metformin + sitagliptin +/- repaglinide
13	Autoimmune Diabetes: Disease Markers and Treatment of Latent Autoimmune Diabetes in Adults (LADA)	Withdrawn	NCT01148238

Search NIH Clinical Center for Type 1 Diabetes Mellitus 5

Cochrane evidence based reviews: latent autoimmune diabetes in adults

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Genetic Tests for Type 1 Diabetes Mellitus 5

Genetic tests related to Type 1 Diabetes Mellitus 5:

#	Genetic test	Affiliating Genes
1	Type 1 Diabetes Mellitus 5 ²⁸	SUMO4

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Anatomical Context for Type 1 Diabetes Mellitus 5

Organs/tissues related to Type 1 Diabetes Mellitus 5:

MalaCards : Lymph Node, Pancreatic Islet, Thyroid, T Cells, Pancreas, Neutrophil, Ovary

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Publications for Type 1 Diabetes Mellitus 5

Articles related to Type 1 Diabetes Mellitus 5:

(show top 50) (show all 863)

#	Title	Authors	PMID	Year
1	A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. ⁶² ⁵⁷ ⁵	Guo D...Wang CY	15247916	2004
2	A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. ⁵⁷ ⁵	Bohren KM...Owerbach D	15123604	2004
3	Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8. ⁶² ⁵⁷	Luo DF...She JX	8733139	1996
4	A genome-wide search for human type 1 diabetes susceptibility genes. ⁶² ⁵⁷	Davies JL...Palmer SM	8072542	1994
5	Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. ⁵	Qu H...Polychronakos C	15678135	2005
6	Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. ⁵	Smyth DJ...Todd JA	15678134	2005
7	Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. ⁵	Park Y...Kim D	15678137	2005
8	Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis. ⁵⁷	Fox CJ...Danska JS	10848492	2000
9	A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. ⁵⁷	Concannon P...Spielman RS	9662408	1998
10	Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults. ⁶²	Edstorp J...Carlsson S	35900371	2023
11	Can SARS-CoV-2 trigger new onset of autoimmune disease in adults? A case-based review. ⁶²	Putry BO...Pasiak TF	36338884	2022
12	The continuous spectrum of glycaemic variability changes with pancreatic islet function: A multicentre cross-sectional study in China. ⁶²	Zhang L...Yang L	36214297	2022
13	Altered brain spontaneous and synchronization activity in latent autoimmune diabetes in adults: A resting-state functional MRI study. ⁶²	Miao Y...Zhu D	36306532	2022
14	Diagnostic camouflage: A case report on Latent autoimmune diabetics of adulthood. ⁶²	Neupane SK...Neupane PK	36268330	2022
15	Genome-resolved analyses show an extensive diversification in key aerobic hydrocarbon-degrading enzymes across bacteria and archaea. ⁶²	Somee MR...Mehrshad M	36203131	2022
16	Linking the region-specific tissue microstructure to the biaxial mechanical properties of the porcine left anterior descending artery. ⁶²	Pineda-Castillo SA...Lee CH	35905825	2022
17	Birthweight, BMI in adulthood and latent autoimmune diabetes in adults: a Mendelian randomisation study. ⁶²	Wei Y...Carlsson S	35606578	2022
18	Adult-onset autoimmune diabetes. ⁶²	Buzzetti R...Boehm BO	36138034	2022
19	Efficacy and safety of sitagliptin and insulin for latent autoimmune diabetes in adults: A systematic review and meta-analysis. ⁶²	Lin T...Liu C	35445591	2022
20	Sphingomyelin profiling in patients with diabetes could be potentially useful as differential diagnostics biomarker: A pilot study. ⁶²	Sokolowska E...Siewko K	35785598	2022
21	Thyroid autoantibody distribution in patients with latent autoimmune diabetes in youth: a multicenter, national survey. ⁶²	Nan X...Zhou Z	36111021	2022
22	Diabetic ketoacidosis as first presentation of latent autoimmune diabetes in adults in a patient with hashitoxicosis as first presentation of Hashimoto's thyroiditis: a case report. ⁶²	Xenou M...Fousteris E	35918735	2022
23	Multifocal Neuroarthropathy of the Knee and Foot Induced by Physical Training of the Lower Extremities in a Patient With Latent Autoimmune Diabetes in Adults. ⁶²	Kojima C...Nakamura J	36148208	2022
24	Latent autoimmune diabetes in youth shows greater autoimmunity than latent autoimmune diabetes in adults: Evidence from a nationwide, multicenter, cross-sectional study. ⁶²	Cheng J...Li X	35451144	2022
25	The Association of CTLA-4 rs231775 and rs3087243 Polymorphisms with Latent Autoimmune Diabetes in Adults: A Meta-Analysis. ⁶²	Pang H...Zhou Z	34822071	2022
26	Locality Adaptive Discriminant Analysis Framework. ⁶²	Li X...Chen M	33502996	2022
27	Locality-Aware Crowd Counting. ⁶²	Zhou JT...Zhu H	33534703	2022
28	Rapid Point-of-Care Test for Determination of C-Peptide Levels. ⁶²	Rao PV...Nagalla SR	33729032	2022
29	Prevalence and factors associated with latent autoimmune diabetes in adults (LADA): a cross-sectional study. ⁶²	Manisha AM...Mbugi EV	35804315	2022
30	Nursing a patient with latent autoimmune diabetes in adults with insulin-related lipodystrophy, allergy, and exogenous insulin autoimmune syndrome: A case report. ⁶²	He F...Dong YX	36051121	2022
31	Atypical Diabetes and Management Considerations. ⁶²	Patil SP	35595479	2022
32	The role of renal damage markers in the diagnosis of early stages of kidney injury in patients with latent autoimmune diabetes in adults. ⁶²	Tsaryk I...Pashkovska N	35928354	2022
33	Small RNAs are differentially expressed in autoimmune and non-autoimmune diabetes and controls. ⁶²	Sorgjerd EP...Asvold BO	35616612	2022
34	Early life Bacillus Calmette-Guerin vaccination and incidence of type 1, type 2, and latent autoimmune diabetes in adulthood. ⁶²	Corsenac P...Rousseau MC	35245655	2022
35	Self-reported Severe and Nonsevere Hypoglycemia in Type 1 Diabetes: Population Surveillance Through the BETTER Patient Engagement Registry: Development and Baseline Characteristics. ⁶²	Brazeau AS...BETTER Study Group	35835670	2022
36	Mutual enhancing learning-based automatic segmentation of CT cardiac substructure. ⁶²	Momin S...Yang X	35447610	2022
37	An Unsuspected Case of Euglycemic Diabetic Ketoacidosis With Twists. ⁶²	Kang CY...Reyes Pinzon V	35573514	2022
38	Prediction of Heat Transfer and Fluid Flow Effects on Entropy Generation in a Monolithic Catalytic Converter Using Large-Eddy Simulation. ⁶²	Li Y...Ries F	35626487	2022
39	Diagnostic Dilemmas and Current Treatment Approaches in Latent Onset Autoimmune Diabetes in Adults: A Concise Review. ⁶²	Chandran L...Chitra V	35331118	2022
40	Erratum. Characteristics of the Gut Microbiota and Metabolism in Patients With Latent Autoimmune Diabetes in Adults: A Case-Control Study. Diabetes Care 2021;44:2738-2746. ⁶²	Fang Y...Yuan H	35020835	2022
41	Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL1-ra and IL-1 beta is associated with progressive disease. ⁶²	Hals IK...Grill V	35066451	2022
42	The Differential Expression of Circular RNAs in Type 2 Diabetes Mellitus and Latent Autoimmune Diabetes in Adults. ⁶²	Ning L...Cai H	35349376	2022
43	Two Fifth-Generation Fighter Pilots Discovered with Latent Autoimmune Diabetes. ⁶²	Zhang JX...Sauerwein TJ	35105428	2022
44	Progression of Diabetic Complications in Subgroups of People with Long Term Diabetes Type 1 According to Clinical Course. ⁶²	Gerdes C...Muller N	32777840	2022
45	A Case of Late Diagnosis of Latent Autoimmune Diabetes in Adults. ⁶²	Costa JR...Abuowda Y	35282513	2022
46	Assessment of Hydrocarbon Degradation Potential in Microbial Communities in Arctic Sea Ice. ⁶²	Peeb A...Truu J	35208784	2022
47	Identification of long-chain alkane-degrading (LadA) monooxygenases in Aspergillus flavus via in silico analysis. ⁶²	Perera M...Jayasena S	36110294	2022
48	Lifestyle or Environmental Influences and Their Interaction With Genetic Susceptibility on the Risk of LADA. ⁶²	Carlsson S	35846274	2022
49	Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients. ⁶²	Zhou Y...Xia J	35242878	2022
50	GAD65 Antibody Epitopes and Genetic Background in Latent Autoimmune Diabetes in Youth (LADY). ⁶²	Peng Y...Zhou Z	35392100	2022

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Genes for Type 1 Diabetes Mellitus 5

Genes related to Type 1 Diabetes Mellitus 5 (2 elite genes):

(show all 25)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	SUMO4	Small Ubiquitin Like Modifier 4	Protein Coding	1063.52	Molecular basis known ⁵⁷ Pathogenic ⁵ Genetic Tests ²⁸ Susceptibility factor ⁵⁷ DISEASES inferred ¹⁴ ¹⁴	15123604 15247916 15678134 (more) 15678135 15678137
2	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	405.6	Pathogenic ⁵ DISEASES inferred ¹⁴	15123604 15247916 15678134 (more) 15678135 15678137
3	INS	Insulin	Protein Coding	12.63	DISEASES inferred ¹⁴ ¹⁴
4	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	11.98	DISEASES inferred ¹⁴ ¹⁴
5	GAD2	Glutamate Decarboxylase 2	Protein Coding	11.92	DISEASES inferred ¹⁴ ¹⁴
6	SLC30A8	Solute Carrier Family 30 Member 8	Protein Coding	11.84	DISEASES inferred ¹⁴ ¹⁴
7	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	11.56	DISEASES inferred ¹⁴ ¹⁴
8	PTPN22	Protein Tyrosine Phosphatase Non-Receptor Type 22	Protein Coding	11.2	DISEASES inferred ¹⁴ ¹⁴
9	SLC30A10	Solute Carrier Family 30 Member 10	Protein Coding	11.03	DISEASES inferred ¹⁴ ¹⁴
10	PTPRN	Protein Tyrosine Phosphatase Receptor Type N	Protein Coding	10.82	DISEASES inferred ¹⁴ ¹⁴
11	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	10.39	DISEASES inferred ¹⁴ ¹⁴
12	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	9.84	DISEASES inferred ¹⁴ ¹⁴
13	INSM2	INSM Transcriptional Repressor 2	Protein Coding	9.83	DISEASES inferred ¹⁴ ¹⁴
14	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	9.82	DISEASES inferred ¹⁴ ¹⁴
15	PTPRN2	Protein Tyrosine Phosphatase Receptor Type N2	Protein Coding	9.18	DISEASES inferred ¹⁴ ¹⁴
16	TOR1A	Torsin Family 1 Member A	Protein Coding	8.78	DISEASES inferred ¹⁴ ¹⁴
17	TG	Thyroglobulin	Protein Coding	8.01	DISEASES inferred ¹⁴ ¹⁴
18	SH2B3	SH2B Adaptor Protein 3	Protein Coding	7.95	DISEASES inferred ¹⁴ ¹⁴
19	CPE	Carboxypeptidase E	Protein Coding	7.92	DISEASES inferred ¹⁴ ¹⁴
20	SOX13	SRY-Box Transcription Factor 13	Protein Coding	7.76	DISEASES inferred ¹⁴ ¹⁴
21	CAPSL	Calcyphosine Like	Protein Coding	7.75	DISEASES inferred ¹⁴ ¹⁴
22	CDKAL1	CDK5 Regulatory Subunit Associated Protein 1 Like 1	Protein Coding	7.74	DISEASES inferred ¹⁴ ¹⁴
23	CTRB2	Chymotrypsinogen B2	Protein Coding	7.73	DISEASES inferred ¹⁴ ¹⁴
24	ICA1	Islet Cell Autoantigen 1	Protein Coding	7.54	DISEASES inferred ¹⁴ ¹⁴
25	FOXP3	Forkhead Box P3	Protein Coding	7.51	DISEASES inferred ¹⁴ ¹⁴

Sources

Variations for Type 1 Diabetes Mellitus 5

ClinVar genetic disease variations for Type 1 Diabetes Mellitus 5:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	TAB2, SUMO4	NM_001002255.2(SUMO4):c.163G>A (p.Val55Met)	SNV	Pathogenic	2062	rs237025	GRCh37: 6:149721690-149721690 GRCh38: 6:149400554-149400554

Sources

Expression for Type 1 Diabetes Mellitus 5

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 5.

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Pathways for Type 1 Diabetes Mellitus 5

Pathways related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ³	12.18	TNFRSF25 TAB2 PTPN22 CTLA4
2	CD28 co-stimulation ⁶⁶ Show member pathways Activation of AKT2 ⁶⁶ CD28 dependent PI3K/Akt signaling ⁶⁶ CD28 dependent Vav1 pathway ⁶⁶ Costimulation by the CD28 family ⁶⁶ CTLA4 Signaling ⁶⁴ VEGFR2 mediated vascular permeability ⁶⁶	11.84	PTPN22 HLA-DQB1 HLA-DQA1 CTLA4
3	TCR signaling (REACTOME) ⁶⁶ Show member pathways Downstream TCR signaling ⁶⁶ Translocation of ZAP-70 to Immunological synapse ⁶⁶	11.63	TAB2 PTPN22 HLA-DQB1 HLA-DQA1
4	Allograft rejection ⁷⁴	11.47	HLA-DQB1 HLA-DQA1 CTLA4
5	Phosphorylation of CD3 and TCR zeta chains ⁶⁶ Show member pathways Generation of second messenger molecules ⁶⁶ PD-1 signaling ⁶⁶	11.33	PTPN22 HLA-DQB1 HLA-DQA1
6	Genes associated with the development of rheumatoid arthritis ⁷⁴	10.66	PTPN22 CTLA4
7	Insulin processing ⁶⁶	10.2	SLC30A8 INS CPE

Sources

GO Terms for Type 1 Diabetes Mellitus 5

Cellular components related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi apparatus	GO:0005794	10.07	TNFRSF10A SLC30A8 SLC30A10 PTPRN HLA-DQA1 GAD2
2	cytoplasmic vesicle	GO:0031410	9.7	TOR1A SLC30A8 PTPRN2 PTPRN GAD2 CPE
3	secretory granule	GO:0030141	9.56	TOR1A SLC30A8 PTPRN2 PTPRN
4	transport vesicle membrane	GO:0030658	9.32	SLC30A8 PTPRN2 PTPRN HLA-DQB1 HLA-DQA1 CPE

Biological processes related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	insulin secretion involved in cellular response to glucose stimulus	GO:0035773	9.62	PTPRN2 PTPRN
2	insulin processing	GO:0030070	9.46	SLC30A8 CPE
3	immunoglobulin production involved in immunoglobulin-mediated immune response	GO:0002381	9.26	HLA-DQB1 HLA-DQA1
4	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	8.96	HLA-DQB1 HLA-DQA1
5	regulation of secretion	GO:0051046	8.92	PTPRN2 PTPRN