Type 1 Diabetes Mellitus 5 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Type 1 Diabetes Mellitus 5

MalaCards integrated aliases for Type 1 Diabetes Mellitus 5:

Name: Type 1 Diabetes Mellitus 5 ¹² ¹⁵

Diabetes Mellitus, Insulin-Dependent, 5 ⁷³

Insulin-Dependent Diabetes Mellitus 5 ¹²

Iddm5 ¹²

Classifications:

MalaCards categories:
Global: Metabolic diseases Genetic diseases
Anatomical: Endocrine diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Endocrine, nutritional and metabolic diseases

Diabetes mellitus

Insulin-dependent diabetes mellitus

External Ids:

Disease Ontology ¹² DOID:0110744

ICD10 ³³ E10

UMLS ⁷³ C1838260

Sources

Summaries for Type 1 Diabetes Mellitus 5

Disease Ontology : ¹² A type 1 diabetes mellitus that has material basis in mutation of the SUMO4 gene on chromosome 6q25.1.

MalaCards based summary : Type 1 Diabetes Mellitus 5, also known as diabetes mellitus, insulin-dependent, 5, is related to diabetes mellitus, insulin-dependent, 5 and type 1 diabetes mellitus 15. An important gene associated with Type 1 Diabetes Mellitus 5 is SUMO4 (Small Ubiquitin-Like Modifier 4), and among its related pathways/superpathways are TNFR1 Pathway and TRAF Pathway. Affiliated tissues include t cells, and related phenotypes are immune system and mortality/aging

Sources

Related Diseases for Type 1 Diabetes Mellitus 5

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune	Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3	Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5	Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7	Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10	Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12	Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15	Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)

#	Related Disease	Score	Top Affiliating Genes
1	diabetes mellitus, insulin-dependent, 5	32.2	TAB2 SUMO4
2	type 1 diabetes mellitus 15	10.2	INS HCCS
3	type 1 diabetes mellitus 13	10.2	CTLA4 INS
4	hirata disease	10.2	TNFRSF10A INS
5	autoimmune addison disease	10.1	CTLA4 AIRE
6	herpangina	10.1	TNFRSF10A TNFRSF25
7	type 1 diabetes mellitus 2	10.1	TNFRSF25 INS FGF3
8	autoimmune disease of gastrointestinal tract	10.1	TNFRSF25 TNFRSF10A CTLA4
9	neuroretinitis	10.1	CTLA4 TNFRSF10A
10	hypoglycemic coma	10.1	INS HBA2
11	type 1 diabetes mellitus 7	10.1	INS HBA2
12	celiac disease 1	10.1	TNFRSF25 TNFRSF10A CTLA4
13	rheumatoid arthritis	10.1
14	arthritis	10.1
15	diabetes mellitus	10.1
16	pernicious anemia	10.1	AIRE FUT2
17	type 1 diabetes mellitus 17	10.1	TNFRSF25 CTLA4 AIRE
18	type 1 diabetes mellitus 12	10.1	SUMO4 INS FGF3 CTLA4
19	background diabetic retinopathy	10.1	HBA2 INS
20	adrenal cortical hypofunction	10.0	AIRE TNFRSF25
21	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	10.0	INS CTLA4 AIRE
22	diabetic autonomic neuropathy	10.0	HBA2 INS
23	type 1 diabetes mellitus 18	10.0	TNFRSF25 TNFRSF10A LAD1
24	cholangitis, primary sclerosing	10.0	TNFRSF25 FUT2 AIRE
25	type 1 diabetes mellitus 3	10.0	HCCS BBX
26	maturity-onset diabetes of the young, type 13	9.9	INS LAD1
27	immune system disease	9.9	TNFRSF25 TNFRSF10A CTLA4 AIRE
28	type 1 diabetes mellitus 6	9.9	NPL INS HCCS FUT2
29	type 1 diabetes mellitus 11	9.9	TNFRSF25 INS HBA2 CTLA4
30	autonomic nervous system disease	9.9	HBA2 INS
31	type 1 diabetes mellitus 10	9.9	TNFRSF10A NPL HCCS FUT2 CTLA4
32	autoimmune disease of endocrine system	9.8	TNFRSF25 TNFRSF10A INS CTLA4 AIRE
33	glucose metabolism disease	9.8	TNFRSF25 LAD1 INS HBA2
34	diabetes mellitus, insulin-dependent	9.7	TNFRSF25 TNFRSF10A TAB2 SUMO4 INS CTLA4

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 5:

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Symptoms & Phenotypes for Type 1 Diabetes Mellitus 5

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 5:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.7	AIRE BBX CTLA4 FGF3 FUT2 INS
2	mortality/aging	MP:0010768	9.36	AIRE CTLA4 FGF3 HBA2 HCCS INS

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Drugs & Therapeutics for Type 1 Diabetes Mellitus 5

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 5

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Genetic Tests for Type 1 Diabetes Mellitus 5

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Anatomical Context for Type 1 Diabetes Mellitus 5

MalaCards organs/tissues related to Type 1 Diabetes Mellitus 5:

⁴¹

T Cells

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Publications for Type 1 Diabetes Mellitus 5

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Genes for Type 1 Diabetes Mellitus 5

Genes related to Type 1 Diabetes Mellitus 5 (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SUMO4	Small Ubiquitin-Like Modifier 4	Protein Coding	18.8	DISEASES inferred ¹⁵
2	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	16.76	DISEASES inferred ¹⁵
3	TULP4	Tubby Like Protein 4	Protein Coding	16.48	DISEASES inferred ¹⁵
4	PCMT1	Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase	Protein Coding	15.9	DISEASES inferred ¹⁵
5	FGF3	Fibroblast Growth Factor 3	Protein Coding	15.58	DISEASES inferred ¹⁵
6	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	14.77	DISEASES inferred ¹⁵
7	HCCS	Holocytochrome C Synthase	Protein Coding	14.72	DISEASES inferred ¹⁵
8	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	14.66	DISEASES inferred ¹⁵
9	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	14.44	DISEASES inferred ¹⁵
10	INS	Insulin	Protein Coding	14.31	DISEASES inferred ¹⁵
11	FUT2	Fucosyltransferase 2	Protein Coding	14.26	DISEASES inferred ¹⁵
12	SUMO1	Small Ubiquitin-Like Modifier 1	Protein Coding	14.18	DISEASES inferred ¹⁵
13	NPL	N-Acetylneuraminate Pyruvate Lyase	Protein Coding	14.18	DISEASES inferred ¹⁵
14	AIRE	Autoimmune Regulator	Protein Coding	13.7	DISEASES inferred ¹⁵
15	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	13.45	DISEASES inferred ¹⁵
16	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	13.35	DISEASES inferred ¹⁵
17	BBX	BBX, HMG-Box Containing	Protein Coding	5.8	DISEASES inferred ¹⁵
18	LAD1	Ladinin 1	Protein Coding	5.03	DISEASES inferred ¹⁵

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Variations for Type 1 Diabetes Mellitus 5

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Expression for Type 1 Diabetes Mellitus 5

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 5.

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Pathways for Type 1 Diabetes Mellitus 5

Pathways related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ DR3 Signaling ⁶⁴ Fas Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.34	NFKBIA SUMO1 TAB2 TNFRSF10A TNFRSF25
2	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	12.09	NFKBIA TAB2 TNFRSF10A TNFRSF25
3	NF-kappaB Signaling ⁴	11.77	CTLA4 NFKBIA TAB2 TNFRSF25
4	NF-kB (NFkB) Pathway ⁶⁷	10.66	NFKBIA SUMO1 SUMO4

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GO Terms for Type 1 Diabetes Mellitus 5

Biological processes related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cellular protein metabolic process	GO:0032270	8.62	INS NFKBIA

Molecular functions related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein tag	GO:0031386	8.62	SUMO1 SUMO4

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Sources for Type 1 Diabetes Mellitus 5

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

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¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Type 1 Diabetes Mellitus 5 (IDDM5)

Aliases & Classifications for Type 1 Diabetes Mellitus 5

MalaCards integrated aliases for Type 1 Diabetes Mellitus 5:

Classifications:

External Ids:

Summaries for Type 1 Diabetes Mellitus 5

Related Diseases for Type 1 Diabetes Mellitus 5

Diseases in the Diabetes Mellitus family:

Diseases related to Type 1 Diabetes Mellitus 5 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 5:

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 5

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 5:

Drugs & Therapeutics for Type 1 Diabetes Mellitus 5

Genetic Tests for Type 1 Diabetes Mellitus 5

Anatomical Context for Type 1 Diabetes Mellitus 5

MalaCards organs/tissues related to Type 1 Diabetes Mellitus 5:

Publications for Type 1 Diabetes Mellitus 5

Genes for Type 1 Diabetes Mellitus 5

Genes related to Type 1 Diabetes Mellitus 5 (0 elite genes):

Variations for Type 1 Diabetes Mellitus 5

Expression for Type 1 Diabetes Mellitus 5

Pathways for Type 1 Diabetes Mellitus 5

Pathways related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

GO Terms for Type 1 Diabetes Mellitus 5

Biological processes related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

Molecular functions related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

Sources for Type 1 Diabetes Mellitus 5