MCID: TYP031
MIFTS: 23

Type 1 Diabetes Mellitus 5

Categories: Metabolic diseases, Endocrine diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 5

MalaCards integrated aliases for Type 1 Diabetes Mellitus 5:

Name: Type 1 Diabetes Mellitus 5 12 15
Diabetes Mellitus, Insulin-Dependent, 5 73
Insulin-Dependent Diabetes Mellitus 5 12
Iddm5 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110744
ICD10 33 E10
UMLS 73 C1838260

Summaries for Type 1 Diabetes Mellitus 5

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the SUMO4 gene on chromosome 6q25.1.

MalaCards based summary : Type 1 Diabetes Mellitus 5, also known as diabetes mellitus, insulin-dependent, 5, is related to diabetes mellitus, insulin-dependent, 5 and type 1 diabetes mellitus 15. An important gene associated with Type 1 Diabetes Mellitus 5 is SUMO4 (Small Ubiquitin-Like Modifier 4), and among its related pathways/superpathways are NF-kappaB Signaling and TNFR1 Pathway. Related phenotypes are immune system and mortality/aging

Related Diseases for Type 1 Diabetes Mellitus 5

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent, 5 32.6 SUMO4 TAB2
2 type 1 diabetes mellitus 15 10.5 HCCS INS
3 autoimmune addison disease 10.3 AIRE CTLA4
4 autoimmune disease of gastrointestinal tract 10.3 CTLA4 TNFRSF10A TNFRSF25
5 type 1 diabetes mellitus 13 10.2 CTLA4 INS
6 autoimmune polyendocrine syndrome, type ii 10.2 AIRE INS
7 type 1 diabetes mellitus 17 10.1 AIRE CTLA4 TNFRSF25
8 type 1 diabetes mellitus 12 10.1 CTLA4 FGF3 INS SUMO4
9 hypoglycemic coma 10.1 HBA2 INS
10 type 1 diabetes mellitus 7 10.0 HBA2 INS
11 type 1 diabetes mellitus 2 10.0 CTLA4 FGF3 INS TNFRSF25
12 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 AIRE CTLA4 INS
13 type 1 diabetes mellitus 18 10.0 LAD1 TNFRSF10A TNFRSF25
14 celiac disease 1 10.0 CTLA4 TNFRSF10A TNFRSF25
15 cholangitis, primary sclerosing 10.0 AIRE FUT2 TNFRSF25
16 type 1 diabetes mellitus 3 9.9 BBX HCCS
17 rheumatoid arthritis 9.9
18 arthritis 9.9
19 diabetes mellitus 9.9
20 pernicious anemia 9.9 AIRE FUT2
21 autoimmune disease of endocrine system 9.8 AIRE CTLA4 TNFRSF10A TNFRSF25
22 hypersensitivity reaction disease 9.8 AIRE CTLA4 TNFRSF10A TNFRSF25
23 type 1 diabetes mellitus 6 9.8 FUT2 HCCS INS NPL
24 adrenal cortical hypofunction 9.7 AIRE TNFRSF25
25 type 1 diabetes mellitus 11 9.7 CTLA4 HBA2 INS TNFRSF25
26 type 1 diabetes mellitus 10 9.5 CTLA4 FUT2 HCCS NPL TNFRSF10A
27 glucose metabolism disease 9.3 HBA2 INS LAD1 TNFRSF25
28 diabetes mellitus, insulin-dependent 9.3 AIRE CTLA4 INS SUMO4 TAB2 TNFRSF25

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 5:



Diseases related to Type 1 Diabetes Mellitus 5

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 5

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 5:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 TAB2 TNFRSF10A TNFRSF25 AIRE BBX CTLA4
2 mortality/aging MP:0010768 9.36 AIRE CTLA4 FGF3 HBA2 HCCS INS

Drugs & Therapeutics for Type 1 Diabetes Mellitus 5

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 5

Genetic Tests for Type 1 Diabetes Mellitus 5

Anatomical Context for Type 1 Diabetes Mellitus 5

Publications for Type 1 Diabetes Mellitus 5

Variations for Type 1 Diabetes Mellitus 5

Expression for Type 1 Diabetes Mellitus 5

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 5.

Pathways for Type 1 Diabetes Mellitus 5

GO Terms for Type 1 Diabetes Mellitus 5

Biological processes related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.43 INS TNFRSF10A TNFRSF25
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.33 INS NFKBIA TAB2
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.13 NFKBIA TNFRSF10A TNFRSF25
4 positive regulation of cellular protein metabolic process GO:0032270 8.62 INS NFKBIA

Molecular functions related to Type 1 Diabetes Mellitus 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.96 TNFRSF10A TNFRSF25
2 protein tag GO:0031386 8.62 SUMO1 SUMO4

Sources for Type 1 Diabetes Mellitus 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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