IDDM6
MCID: TYP032
MIFTS: 28

Type 1 Diabetes Mellitus 6 (IDDM6)

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 6

MalaCards integrated aliases for Type 1 Diabetes Mellitus 6:

Name: Type 1 Diabetes Mellitus 6 12 15
Diabetes Mellitus, Insulin-Dependent, 6 73
Insulin-Dependent Diabetes Mellitus 6 12
Iddm6 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110745
ICD10 33 E10
UMLS 73 C1866041

Summaries for Type 1 Diabetes Mellitus 6

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 18q21.

MalaCards based summary : Type 1 Diabetes Mellitus 6, also known as diabetes mellitus, insulin-dependent, 6, is related to diabetes mellitus, insulin-dependent, 6 and diabetes mellitus, insulin-dependent. An important gene associated with Type 1 Diabetes Mellitus 6 is ZNF236 (Zinc Finger Protein 236), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. Affiliated tissues include tongue, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Type 1 Diabetes Mellitus 6

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent, 6 11.8
2 diabetes mellitus, insulin-dependent 11.1
3 perrault syndrome 1 11.1
4 recurrent hypersomnia 10.1 HLA-DQB2 HLA-DQB1
5 maturity-onset diabetes of the young, type 14 10.1 HLA-DQB2 HLA-DQB1
6 glaucomatocyclitic crisis 10.1 HLA-DQB2 HLA-DQB1
7 geographic tongue 10.0 HLA-DQB2 HLA-DQB1
8 type 1 diabetes mellitus 10 10.0 NPL HCCS FUT2
9 kleine-levin hibernation syndrome 10.0 HLA-DQB2 HLA-DQB1
10 maturity-onset diabetes of the young, type 9 10.0 TCF4 INS
11 sulfamethoxazole allergy 9.9 CD86 CD80
12 myositis fibrosa 9.9 CD86 CD80
13 autoimmune peripheral neuropathy 9.9 CD86 CD80
14 type 1 diabetes mellitus 15 9.9 INS HCCS
15 exanthema subitum 9.9 CD86 CD80
16 type 1 diabetes mellitus 5 9.7 NPL INS HCCS FUT2
17 type 1 diabetes mellitus 13 9.7 INS CD86 CD80
18 large intestine cancer 9.6 INS DCC CD86
19 autoimmune disease 9.5 INS HLA-DQB1 CD80

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 6:



Diseases related to Type 1 Diabetes Mellitus 6

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 6

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 6 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.32 RPSA
2 Decreased viability GR00240-S-1 9.32 CD80 CD86 HCCS RPSA
3 Decreased viability GR00381-A-1 9.32 RPSA
4 Decreased viability GR00402-S-2 9.32 CD80 CD86 HCCS RPSA

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 6:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 CD80 CD86 HLA-DQB1 INS RPSA TCF4
2 hematopoietic system MP:0005397 9.5 CD80 CD86 DCC HLA-DQB1 INS RPSA
3 immune system MP:0005387 9.23 CD80 CD86 DCC FUT2 HLA-DQB1 INS

Drugs & Therapeutics for Type 1 Diabetes Mellitus 6

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 6

Genetic Tests for Type 1 Diabetes Mellitus 6

Anatomical Context for Type 1 Diabetes Mellitus 6

MalaCards organs/tissues related to Type 1 Diabetes Mellitus 6:

41
Tongue

Publications for Type 1 Diabetes Mellitus 6

Variations for Type 1 Diabetes Mellitus 6

Expression for Type 1 Diabetes Mellitus 6

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 6.

Pathways for Type 1 Diabetes Mellitus 6

Pathways related to Type 1 Diabetes Mellitus 6 according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.29 CD80 CD86 HLA-DQB1 HLA-DQB2 INS
2
Show member pathways
12.18 CD80 CD86 HLA-DQB1 HLA-DQB2
3
Show member pathways
12.03 CD80 CD86 HLA-DQB1
4 11.7 CD80 CD86 HLA-DQB1
5 11.39 CD80 CD86 HLA-DQB1
6 11.25 CD80 CD86
7 11.2 CD80 CD86
8 11.18 CD80 CD86 HLA-DQB1
9 11.16 CD80 CD86
10
Show member pathways
11.16 CD80 CD86 HLA-DQB1 HLA-DQB2
11 11 CD80 CD86
12 10.98 CD80 CD86 HLA-DQB1
13 10.95 CD80 CD86

GO Terms for Type 1 Diabetes Mellitus 6

Cellular components related to Type 1 Diabetes Mellitus 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DQB2
2 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DQB2
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DQB2
4 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DQB2

Biological processes related to Type 1 Diabetes Mellitus 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 CD80 CD86 HLA-DQB1 HLA-DQB2
2 carbohydrate metabolic process GO:0005975 9.54 FUT2 INS NPL
3 T cell costimulation GO:0031295 9.46 CD80 CD86
4 antigen processing and presentation GO:0019882 9.43 HLA-DQB1 HLA-DQB2
5 positive regulation of protein kinase B signaling GO:0051897 9.43 CD80 CD86 INS
6 negative regulation of T cell proliferation GO:0042130 9.4 CD80 CD86
7 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.16 HLA-DQB1 HLA-DQB2
8 positive regulation of interleukin-2 biosynthetic process GO:0045086 8.96 CD80 CD86
9 viral entry into host cell GO:0046718 8.8 CD80 CD86 RPSA

Molecular functions related to Type 1 Diabetes Mellitus 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.16 CD80 CD86
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DQB2
3 virus receptor activity GO:0001618 8.8 CD80 CD86 RPSA

Sources for Type 1 Diabetes Mellitus 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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