IDDM6
MCID: TYP032
MIFTS: 25

Type 1 Diabetes Mellitus 6 (IDDM6)

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 6

MalaCards integrated aliases for Type 1 Diabetes Mellitus 6:

Name: Type 1 Diabetes Mellitus 6 12 15
Diabetes Mellitus, Insulin-Dependent, 6 74
Insulin-Dependent Diabetes Mellitus 6 12
Iddm6 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110745
ICD10 34 E10
UMLS 74 C1866041

Summaries for Type 1 Diabetes Mellitus 6

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 18q21.

MalaCards based summary : Type 1 Diabetes Mellitus 6, also known as diabetes mellitus, insulin-dependent, 6, is related to diabetes mellitus, insulin-dependent, 6 and diabetes mellitus, insulin-dependent. An important gene associated with Type 1 Diabetes Mellitus 6 is ZNF236 (Zinc Finger Protein 236), and among its related pathways/superpathways are ICos-ICosL Pathway in T-Helper Cell and CD28 co-stimulation. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Type 1 Diabetes Mellitus 6

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 6:



Diseases related to Type 1 Diabetes Mellitus 6

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 6

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 6 according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.4 RPSA
2 Decreased viability GR00240-S-1 9.4 CD80 CD86 HCCS RPSA SPON1
3 Decreased viability GR00381-A-1 9.4 RPSA
4 Decreased viability GR00402-S-2 9.4 CD80 CD86 HCCS RPSA SPON1

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 6:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 CD80 CD86 DCC FUT2 HLA-DQB1 NPL

Drugs & Therapeutics for Type 1 Diabetes Mellitus 6

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 6

Genetic Tests for Type 1 Diabetes Mellitus 6

Anatomical Context for Type 1 Diabetes Mellitus 6

Publications for Type 1 Diabetes Mellitus 6

Variations for Type 1 Diabetes Mellitus 6

Expression for Type 1 Diabetes Mellitus 6

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 6.

Pathways for Type 1 Diabetes Mellitus 6

GO Terms for Type 1 Diabetes Mellitus 6

Biological processes related to Type 1 Diabetes Mellitus 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.32 CD80 CD86
2 T cell costimulation GO:0031295 9.26 CD80 CD86
3 negative regulation of T cell proliferation GO:0042130 9.16 CD80 CD86
4 positive regulation of interleukin-2 biosynthetic process GO:0045086 8.96 CD80 CD86
5 viral entry into host cell GO:0046718 8.8 CD80 CD86 RPSA

Molecular functions related to Type 1 Diabetes Mellitus 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.96 CD80 CD86
2 virus receptor activity GO:0001618 8.8 CD80 CD86 RPSA

Sources for Type 1 Diabetes Mellitus 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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