IDDM7
MCID: TYP033
MIFTS: 26

Type 1 Diabetes Mellitus 7 (IDDM7)

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 7

MalaCards integrated aliases for Type 1 Diabetes Mellitus 7:

Name: Type 1 Diabetes Mellitus 7 12 15
Diabetes Mellitus, Insulin-Dependent, 7 74
Insulin-Dependent Diabetes Mellitus 7 12
Iddm7 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110746
ICD10 34 E10
UMLS 74 C1838259

Summaries for Type 1 Diabetes Mellitus 7

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 2q31.

MalaCards based summary : Type 1 Diabetes Mellitus 7, also known as diabetes mellitus, insulin-dependent, 7, is related to diabetes mellitus, insulin-dependent and diabetes mellitus. An important gene associated with Type 1 Diabetes Mellitus 7 is NEUROD1 (Neuronal Differentiation 1), and among its related pathways/superpathways are Insulin receptor recycling and Glucose / Energy Metabolism. Related phenotypes are Increased shRNA abundance and digestive/alimentary

Related Diseases for Type 1 Diabetes Mellitus 7

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent 30.9 PTPRN INS IGFBP1
2 diabetes mellitus 29.3 PTPRN NEUROD1 INS IGFBP1
3 diabetes mellitus, insulin-dependent, 7 11.8
4 perrault syndrome 1 11.1
5 retinitis pigmentosa 26 10.2 NEUROD1 HMOX2
6 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.1 HBA2 HBA1
7 methemoglobinemia, beta-globin type 10.1 HBA2 HBA1
8 diabetes mellitus, insulin-dependent, 24 10.1 HBA2 HBA1
9 hydrops fetalis, nonimmune 10.1 HBA2 HBA1
10 hydrops fetalis 10.1 HBA2 HBA1
11 glutathione peroxidase deficiency 10.1 HBA2 HBA1
12 erythrocytosis, familial, 7 10.1 HBA2 HBA1
13 heinz body anemias 10.1 HBA2 HBA1
14 immature cataract 10.1 HBA2 HBA1
15 alpha thalassemia-intellectual disability syndrome type 1 10.0 HBA2 HBA1
16 maturity-onset diabetes of the young, type 3 10.0 NEUROD1 INS
17 hemoglobin h disease 9.9 HBA2 HBA1
18 type 1 diabetes mellitus 12 9.9 SLC11A1 INS
19 hemoglobinopathy 9.9 HBA2 HBA1
20 microcytic anemia 9.9 HBA2 HBA1
21 maturity-onset diabetes of the young, type 7 9.9 NEUROD1 INS
22 background diabetic retinopathy 9.9 INS HBA2
23 diabetic autonomic neuropathy 9.9 INS HBA2
24 autonomic nervous system disease 9.8 INS HBA2
25 pancreatic cystadenoma 9.8 PTPRN INS
26 type 1 diabetes mellitus 5 9.8 INS HBA2
27 hyperproinsulinemia 9.8 INS IGFBP1
28 rubeosis iridis 9.8 INS HBA2
29 gastrointestinal system benign neoplasm 9.8 PTPRN INS
30 endocrine pancreas disease 9.8 INS IGFBP1
31 maturity-onset diabetes of the young, type 13 9.7 PTPRN NEUROD1 INS
32 maturity-onset diabetes of the young, type 6 9.7 PTPRN NEUROD1 INS
33 sickle cell anemia 9.7 HBA1 HBA2
34 type 1 diabetes mellitus 13 9.7 SLC11A1 PTPRN INS
35 hypoglycemic coma 9.6 INS HBA2 HBA1
36 type 1 diabetes mellitus 11 9.6 INS HBA2 HBA1
37 retinal vascular disease 9.6 INS HBA2 HBA1
38 hyperandrogenism 9.6 IGFBP1 INS
39 glucose metabolism disease 9.3 PTPRN INS HBA2 HBA1
40 diabetes mellitus, noninsulin-dependent 9.1 PTPRN NEUROD1 INS IGFBP1 HBA1

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 7:



Diseases related to Type 1 Diabetes Mellitus 7

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 7

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 7 according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 HMOX2 INS SLC11A1

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 7:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 GALNT3 HMOX2 INS NEUROD1 SLC11A1

Drugs & Therapeutics for Type 1 Diabetes Mellitus 7

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 7

Genetic Tests for Type 1 Diabetes Mellitus 7

Anatomical Context for Type 1 Diabetes Mellitus 7

Publications for Type 1 Diabetes Mellitus 7

Variations for Type 1 Diabetes Mellitus 7

Expression for Type 1 Diabetes Mellitus 7

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 7.

Pathways for Type 1 Diabetes Mellitus 7

GO Terms for Type 1 Diabetes Mellitus 7

Cellular components related to Type 1 Diabetes Mellitus 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosolic small ribosomal subunit GO:0022627 9.26 HBA1 HBA2
2 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
3 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
4 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Type 1 Diabetes Mellitus 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular iron ion homeostasis GO:0006879 9.46 HMOX2 SLC11A1
2 response to hydrogen peroxide GO:0042542 9.43 HBA1 HBA2
3 positive regulation of cell death GO:0010942 9.4 HBA1 HBA2
4 positive regulation of cell differentiation GO:0045597 9.37 INS NEUROD1
5 bicarbonate transport GO:0015701 9.32 HBA1 HBA2
6 iron ion homeostasis GO:0055072 9.26 HMOX2 SLC11A1
7 insulin secretion GO:0030073 9.16 NEUROD1 PTPRN
8 hydrogen peroxide catabolic process GO:0042744 8.96 HBA1 HBA2
9 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Type 1 Diabetes Mellitus 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.43 HBA1 HBA2 HMOX2
2 oxygen binding GO:0019825 9.37 HBA1 HBA2
3 peroxidase activity GO:0004601 9.32 HBA1 HBA2
4 oxygen carrier activity GO:0005344 9.16 HBA1 HBA2
5 organic acid binding GO:0043177 8.96 HBA1 HBA2
6 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Type 1 Diabetes Mellitus 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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