MCID: TYP033
MIFTS: 27

Type 1 Diabetes Mellitus 7

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 7

MalaCards integrated aliases for Type 1 Diabetes Mellitus 7:

Name: Type 1 Diabetes Mellitus 7 12 15
Diabetes Mellitus, Insulin-Dependent, 7 74
Insulin-Dependent Diabetes Mellitus 7 12
Iddm7 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110746
ICD10 34 E10
UMLS 74 C1838259

Summaries for Type 1 Diabetes Mellitus 7

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 2q31.

MalaCards based summary : Type 1 Diabetes Mellitus 7, also known as diabetes mellitus, insulin-dependent, 7, is related to diabetes mellitus, insulin-dependent and diabetes mellitus. An important gene associated with Type 1 Diabetes Mellitus 7 is NEUROD1 (Neuronal Differentiation 1), and among its related pathways/superpathways are Insulin receptor recycling and Glucose / Energy Metabolism. Affiliated tissues include pancreas, and related phenotypes are Increased shRNA abundance and digestive/alimentary

Related Diseases for Type 1 Diabetes Mellitus 7

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Type 1 Diabetes Mellitus 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent 31.5 IGFBP1 INS PTPRN
2 diabetes mellitus 29.2 IGFBP1 INS NEUROD1 PTPRN
3 diabetes mellitus, insulin-dependent, 7 12.1
4 cone-rod dystrophy and hearing loss 2 11.1
5 retinitis pigmentosa 26 10.2 HMOX2 NEUROD1
6 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.1 HBA1 HBA2
7 methemoglobinemia, beta-globin type 10.1 HBA1 HBA2
8 diabetes mellitus, insulin-dependent, 24 10.1 HBA1 HBA2
9 hydrops fetalis, nonimmune 10.1 HBA1 HBA2
10 hydrops fetalis 10.1 HBA1 HBA2
11 glutathione peroxidase deficiency 10.1 HBA1 HBA2
12 heinz body anemias 10.1 HBA1 HBA2
13 erythrocytosis, familial, 7 10.1 HBA1 HBA2
14 diabetes mellitus, insulin-dependent, 13 10.1
15 diabetes mellitus, insulin-dependent, 12 10.1
16 immature cataract 10.1 HBA1 HBA2
17 alpha thalassemia-intellectual disability syndrome type 1 10.0 HBA1 HBA2
18 maturity-onset diabetes of the young, type 3 10.0 INS NEUROD1
19 hemoglobin h disease 10.0 HBA1 HBA2
20 type 1 diabetes mellitus 12 9.9 INS SLC11A1
21 hemoglobinopathy 9.9 HBA1 HBA2
22 microcytic anemia 9.9 HBA1 HBA2
23 maturity-onset diabetes of the young, type 7 9.9 INS NEUROD1
24 background diabetic retinopathy 9.9 HBA2 INS
25 diabetic autonomic neuropathy 9.9 HBA2 INS
26 autonomic nervous system disease 9.8 HBA2 INS
27 pancreatic cystadenoma 9.8 INS PTPRN
28 type 1 diabetes mellitus 5 9.8 HBA2 INS
29 rubeosis iridis 9.8 HBA2 INS
30 hyperproinsulinemia 9.8 IGFBP1 INS
31 gastrointestinal system benign neoplasm 9.8 INS PTPRN
32 endocrine pancreas disease 9.7 IGFBP1 INS
33 maturity-onset diabetes of the young, type 13 9.7 INS NEUROD1 PTPRN
34 maturity-onset diabetes of the young, type 6 9.7 INS NEUROD1 PTPRN
35 sickle cell anemia 9.7 HBA1 HBA2
36 type 1 diabetes mellitus 13 9.7 INS PTPRN SLC11A1
37 hypoglycemic coma 9.7 HBA1 HBA2 INS
38 type 1 diabetes mellitus 11 9.6 HBA1 HBA2 INS
39 retinal vascular disease 9.6 HBA1 HBA2 INS
40 hyperandrogenism 9.6 IGFBP1 INS
41 glucose metabolism disease 9.3 HBA1 HBA2 INS PTPRN
42 diabetes mellitus, noninsulin-dependent 9.1 HBA1 IGFBP1 INS NEUROD1 PTPRN

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 7:



Diseases related to Type 1 Diabetes Mellitus 7

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 7

GenomeRNAi Phenotypes related to Type 1 Diabetes Mellitus 7 according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 HMOX2 INS SLC11A1

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus 7:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 GALNT3 HMOX2 INS NEUROD1 SLC11A1

Drugs & Therapeutics for Type 1 Diabetes Mellitus 7

Search Clinical Trials , NIH Clinical Center for Type 1 Diabetes Mellitus 7

Genetic Tests for Type 1 Diabetes Mellitus 7

Anatomical Context for Type 1 Diabetes Mellitus 7

MalaCards organs/tissues related to Type 1 Diabetes Mellitus 7:

42
Pancreas

Publications for Type 1 Diabetes Mellitus 7

Variations for Type 1 Diabetes Mellitus 7

Expression for Type 1 Diabetes Mellitus 7

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 7.

Pathways for Type 1 Diabetes Mellitus 7

GO Terms for Type 1 Diabetes Mellitus 7

Cellular components related to Type 1 Diabetes Mellitus 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosolic small ribosomal subunit GO:0022627 9.26 HBA1 HBA2
2 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
3 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
4 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Type 1 Diabetes Mellitus 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular iron ion homeostasis GO:0006879 9.46 HMOX2 SLC11A1
2 response to hydrogen peroxide GO:0042542 9.43 HBA1 HBA2
3 positive regulation of cell death GO:0010942 9.4 HBA1 HBA2
4 positive regulation of cell differentiation GO:0045597 9.37 INS NEUROD1
5 bicarbonate transport GO:0015701 9.32 HBA1 HBA2
6 iron ion homeostasis GO:0055072 9.26 HMOX2 SLC11A1
7 insulin secretion GO:0030073 9.16 NEUROD1 PTPRN
8 hydrogen peroxide catabolic process GO:0042744 8.96 HBA1 HBA2
9 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Type 1 Diabetes Mellitus 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.43 HBA1 HBA2 HMOX2
2 oxygen binding GO:0019825 9.37 HBA1 HBA2
3 peroxidase activity GO:0004601 9.32 HBA1 HBA2
4 oxygen carrier activity GO:0005344 9.16 HBA1 HBA2
5 organic acid binding GO:0043177 8.96 HBA1 HBA2
6 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Type 1 Diabetes Mellitus 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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