T2D5
MCID: TYP058
MIFTS: 25

Type 2 Diabetes 5 (T2D5)

Categories: Endocrine diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Type 2 Diabetes 5

MalaCards integrated aliases for Type 2 Diabetes 5:

Name: Type 2 Diabetes 5 57
Diabetes Mellitus, Noninsulin-Dependent, 5 57 29 70
Niddm5 57 72
Diabetes Mellitus, Noninsulin-Dependent, 5; Niddm5 57
Diabetes Mellitus, Noninsulin-Dependent, Type 5 39
Type 2 Diabetes Mellitus 5, Susceptibility to 6
Diabetes Mellitus, Non-Insulin-Dependent, 5 72
T2d5 57

Classifications:



External Ids:

OMIM® 57 616087
MeSH 44 D003924
MedGen 41 CN221135
UMLS 70 C4015183

Summaries for Type 2 Diabetes 5

UniProtKB/Swiss-Prot : 72 Diabetes mellitus, non-insulin-dependent, 5: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

MalaCards based summary : Type 2 Diabetes 5, also known as diabetes mellitus, noninsulin-dependent, 5, is related to diabetes mellitus and yemenite deaf-blind hypopigmentation syndrome. An important gene associated with Type 2 Diabetes 5 is TBC1D4 (TBC1 Domain Family Member 4), and among its related pathways/superpathways are Glucose / Energy Metabolism and Angiopoietin Like Protein 8 Regulatory Pathway. Affiliated tissues include kidney, pancreas and endothelial.

More information from OMIM: 616087

Related Diseases for Type 2 Diabetes 5

Graphical network of the top 20 diseases related to Type 2 Diabetes 5:



Diseases related to Type 2 Diabetes 5

Symptoms & Phenotypes for Type 2 Diabetes 5

Clinical features from OMIM®:

616087 (Updated 05-Apr-2021)

Drugs & Therapeutics for Type 2 Diabetes 5

Search Clinical Trials , NIH Clinical Center for Type 2 Diabetes 5

Genetic Tests for Type 2 Diabetes 5

Genetic tests related to Type 2 Diabetes 5:

# Genetic test Affiliating Genes
1 Diabetes Mellitus, Noninsulin-Dependent, 5 29 TBC1D4

Anatomical Context for Type 2 Diabetes 5

MalaCards organs/tissues related to Type 2 Diabetes 5:

40
Kidney, Pancreas, Endothelial

Publications for Type 2 Diabetes 5

Articles related to Type 2 Diabetes 5:

(show all 34)
# Title Authors PMID Year
1
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes. 57 6
25043022 2014
2
AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. 57
23078342 2013
3
Coronary plaque burden in Turner syndrome a coronary computed tomography angiography study. 61
32613319 2021
4
The Association Between Kidney Disease and Diabetes Remission in Bariatric Surgery Patients With Type 2 Diabetes. 61
31331758 2019
5
Assessment of a Multidisciplinary Intervention in Patients With BMI ≥35 kg/m2 and Recently Diagnosed Type 2 Diabetes. 61
30912810 2019
6
Intensive versus standard multifactorial cardiovascular risk factor control in screen-detected type 2 diabetes: 5-year and longer-term modelled outcomes of the ADDITION-Leicester study. 61
30521699 2019
7
Diabetes-Related Behavior Change Knowledge Transfer to Primary Care Practitioners and Patients: Implementation and Evaluation of a Digital Health Platform. 61
29669705 2018
8
Metabolic syndrome and its predictors in an urban population in Kenya: A cross sectional study. 61
28676116 2017
9
Habitual chocolate intake and type 2 diabetes mellitus in the Maine-Syracuse Longitudinal Study: (1975-2010): Prospective observations. 61
27725277 2017
10
Lack of Independent Association Between Fatty Pancreas and Incidence of Type 2 Diabetes: 5-Year Japanese Cohort Study. 61
27422578 2016
11
Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial. 61
26607942 2016
12
Patient-centred care, health behaviours and cardiovascular risk factor levels in people with recently diagnosed type 2 diabetes: 5-year follow-up of the ADDITION-Plus trial cohort. 61
26739725 2016
13
Visual functioning and health-related quality of life in diabetic patients about to undergo anti-vascular endothelial growth factor treatment for sight-threatening macular edema. 61
26318959 2015
14
Bariatric-metabolic surgery versus conventional medical treatment in obese patients with type 2 diabetes: 5 year follow-up of an open-label, single-centre, randomised controlled trial. 61
26369473 2015
15
Poncet's disease: An unusual presentation of tuberculosis in a diabetic lady. 61
25879013 2015
16
Analysis and improvement of organizational models for the management of patients with type 2 diabetes mellitus: a case study in north-east Italy. 61
24710186 2014
17
Trace glucose fluxes in individuals with prediabetes using stable isotopes. 61
24791882 2014
18
Lifestyle interventions for patients with and at risk for type 2 diabetes: a systematic review and meta-analysis. 61
24126648 2013
19
Hypoadiponectinaemia in diabetes mellitus type 2: molecular mechanisms and clinical significance. 61
21916932 2011
20
Glucose, metformin, and AICAR regulate the expression of G protein-coupled receptor members in INS-1 beta cell. 61
19672815 2009
21
Development of life-expectancy tables for people with type 2 diabetes. 61
19109355 2009
22
Addition of thiazolidinedione or exenatide to oral agents in type 2 diabetes: a meta-analysis. 61
18957626 2008
23
New technologies and therapies in the management of diabetes. 61
17417933 2007
24
Insulin detemir: new drug. A second long-acting insulin analogue: many uncertainties, few advantages. 61
17121210 2006
25
Population pharmacokinetics of metformin in late pregnancy. 61
16418696 2006
26
Nitration of gamma-tocopherol prevents its oxidative metabolism by HepG2 cells. 61
16043020 2005
27
Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. 61
12716738 2003
28
Syndrome W: a new model of hyperinsulinemia, hypertension and midlife weight gain in healthy women with normal glucose tolerance. 61
11975838 2002
29
Declining beta-cell function in type 2 diabetes: 5-year follow-up and immunologic studies of the population of Wadena, MN. 61
11833039 2002
30
Antepartum and early postpartum predictors of type 2 diabetes development in women with gestational diabetes mellitus. 61
11852376 2001
31
Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes : 5-year follow-up of the Hoorn Study. 61
10747342 2000
32
Management of type 2 diabetes: long-awaited evidence of benefits after blood sugar control. 61
11503841 1999
33
Normalization of fasting glycaemia by intravenous GLP-1 ([7-36 amide] or [7-37]) in type 2 diabetic patients. 61
9827848 1998
34
Changes in insulin receptor tyrosine kinase activity associated with metformin treatment of type 2 diabetes. 61
8529763 1995

Variations for Type 2 Diabetes 5

ClinVar genetic disease variations for Type 2 Diabetes 5:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TBC1D4 NM_014832.5(TBC1D4):c.2050C>T (p.Arg684Ter) SNV risk factor 157612 rs61736969 GRCh37: 13:75898521-75898521
GRCh38: 13:75324385-75324385

Expression for Type 2 Diabetes 5

Search GEO for disease gene expression data for Type 2 Diabetes 5.

Pathways for Type 2 Diabetes 5

Pathways related to Type 2 Diabetes 5 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 TBC1D4 INS
2
Show member pathways
11.64 TBC1D4 INS
3
Show member pathways
11 TBC1D4 INS
4 10.09 TBC1D4 INS

GO Terms for Type 2 Diabetes 5

Sources for Type 2 Diabetes 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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