MCID: TYP024
MIFTS: 40

Type Ii Mixed Cryoglobulinemia

Categories: Bone diseases, Cardiovascular diseases, Genetic diseases, Immune diseases, Nephrological diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Type Ii Mixed Cryoglobulinemia

Summaries for Type Ii Mixed Cryoglobulinemia

MalaCards based summary : Type Ii Mixed Cryoglobulinemia, also known as mc type ii, is related to autoimmune lymphoproliferative syndrome, type v and cryoglobulinemia, familial mixed. An important gene associated with Type Ii Mixed Cryoglobulinemia is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. Affiliated tissues include testes, lung and bone, and related phenotypes are hematopoietic system and liver/biliary system

Related Diseases for Type Ii Mixed Cryoglobulinemia

Diseases in the Cryoglobulinemia, Familial Mixed family:

Mixed Cryoglobulinemia Type Iii Type Ii Mixed Cryoglobulinemia

Diseases related to Type Ii Mixed Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 autoimmune lymphoproliferative syndrome, type v 30.2 CD5 FAS
2 cryoglobulinemia, familial mixed 10.8
3 cryoglobulinemia 10.8
4 hepatitis 10.6
5 hepatitis c 10.6
6 hepatitis c virus 10.5
7 lymphoma 10.3
8 vasculitis 10.3
9 limbic encephalitis with lgi1 antibodies 10.2 HLA-DQB1 HLA-DRB1
10 narcolepsy 2 10.2 HLA-DQB1 HLA-DRB1
11 narcolepsy 10.2 HLA-DQB1 HLA-DRB1
12 autoimmune polyglandular syndrome type 3 10.2 HLA-DQB1 HLA-DRB1
13 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
14 metal allergy 10.2 HLA-DQB1 HLA-DRB1
15 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
16 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
17 recurrent respiratory papillomatosis 10.2 HLA-DQB1 HLA-DRB1
18 narcolepsy 1 10.2 HLA-DQB1 HLA-DRB1
19 chronic beryllium disease 10.2 HLA-DQB1 HLA-DRB1
20 lichen sclerosus 10.2 HLA-DQB1 HLA-DRB1
21 whipple disease 10.2 HLA-DQB1 HLA-DRB1
22 pityriasis rosea 10.2 HLA-DQB1 HLA-DRB1
23 pediatric multiple sclerosis 10.2 HLA-DQB1 HLA-DRB1
24 microscopic colitis 10.2 HLA-DQB1 HLA-DRB1
25 osteonecrosis of the jaw 10.2 HLA-DQB1 HLA-DRB1
26 idiopathic bronchiectasis 10.2 HLA-DQB1 HLA-DRB1
27 peanut allergy 10.2 HLA-DQB1 HLA-DRB1
28 pure red-cell aplasia 10.1 HLA-DQB1 HLA-DRB1
29 acute disseminated encephalomyelitis 10.1 HLA-DQB1 HLA-DRB1
30 oligoarticular juvenile idiopathic arthritis 10.1 HLA-DQB1 HLA-DRB1
31 glaucomatocyclitic crisis 10.1 HLA-DQB1 HLA-DRB1
32 geographic tongue 10.1 HLA-DQB1 HLA-DRB1
33 panuveitis 10.1 HLA-DQB1 HLA-DRB1
34 b-cell lymphomas 10.1
35 glomerulonephritis 10.1
36 ocular cicatricial pemphigoid 10.1 HLA-DQB1 HLA-DRB1
37 focal epithelial hyperplasia 10.1 HLA-DQB1 HLA-DRB1
38 paraneoplastic pemphigus 10.1 HLA-DQB1 HLA-DRB1
39 rubella 10.0 HLA-DQB1 HLA-DRB1
40 lymphoma, hodgkin, classic 10.0
41 lymphoma, non-hodgkin, familial 10.0
42 liver disease 10.0
43 retinal vasculitis 10.0
44 scleritis 10.0
45 membranoproliferative glomerulonephritis 10.0
46 pyoderma 10.0
47 hepatitis e 10.0
48 proliferative glomerulonephritis 10.0
49 pyoderma gangrenosum 10.0
50 lymphosarcoma 10.0

Graphical network of the top 20 diseases related to Type Ii Mixed Cryoglobulinemia:



Diseases related to Type Ii Mixed Cryoglobulinemia

Symptoms & Phenotypes for Type Ii Mixed Cryoglobulinemia

MGI Mouse Phenotypes related to Type Ii Mixed Cryoglobulinemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.55 CD5 FAS FASLG FN1 HLA-DQB1
2 liver/biliary system MP:0005370 9.26 FAS FASLG FN1 HLA-DQB1
3 normal MP:0002873 9.02 CD5 FAS FASLG FN1 HLA-DQB1

Drugs & Therapeutics for Type Ii Mixed Cryoglobulinemia

Search Clinical Trials , NIH Clinical Center for Type Ii Mixed Cryoglobulinemia

Genetic Tests for Type Ii Mixed Cryoglobulinemia

Anatomical Context for Type Ii Mixed Cryoglobulinemia

MalaCards organs/tissues related to Type Ii Mixed Cryoglobulinemia:

42
Testes, Lung, Bone, B Cells, Heart, Lymph Node, Spinal Cord

Publications for Type Ii Mixed Cryoglobulinemia

Articles related to Type Ii Mixed Cryoglobulinemia:

(show top 50) (show all 2754)
# Title Authors Year
1
Plasma levels of TNF-α, IL-6, IFN-γ, IL-12, IL-17, IL-22, and IL-23 in achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD). ( 30744559 )
2019
2
Association of atrial fibrillation and gastroesophageal reflux disease: Natural and therapeutic linkage of the two common diseases. ( 30805043 )
2019
3
The effectiveness of mindfulness meditation in relief of symptoms of depression and quality of life in patients with gastroesophageal reflux disease. ( 30864012 )
2019
4
The type of dyspepsia is important in the context of patients with irritable bowel syndrome and gastroesophageal reflux disease. ( 30670341 )
2019
5
Proton pump inhibitor monotherapy is effective to attenuate dyspepsia symptoms associated with gastroesophageal reflux disease: a multicenter prospective observational study. ( 30673836 )
2019
6
Reply to: "The type of dyspepsia is important in the context of patients with irritable bowel syndrome and gastroesophageal reflux disease". ( 30704814 )
2019
7
Correction to: Proton pump inhibitor monotherapy is effective to attenuate dyspepsia symptoms associated with gastroesophageal reflux disease: a multicenter prospective observational study. ( 30859319 )
2019
8
IgG4 is Elevated in Eosinophilic Esophagitis but Not in Gastroesophageal Reflux Disease Patients. ( 30614939 )
2019
9
Gastroesophageal reflux symptoms and microscopic esophagitis in a cohort of consecutive patients affected by atrophic body gastritis: a pilot study. ( 30638085 )
2019
10
Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease. ( 30854351 )
2019
11
Unique Clinical Features of Los Angeles Grade D Esophagitis Suggest That Factors Other Than Gastroesophageal Reflux Contribute to its Pathogenesis. ( 28644313 )
2019
12
Proteomics of acquired pellicle in gastroesophageal reflux disease patients with or without erosive tooth wear. ( 30579861 )
2019
13
Comparison of double-flap and OrVil techniques of laparoscopy-assisted proximal gastrectomy in preventing gastroesophageal reflux: a retrospective cohort study. ( 30612151 )
2019
14
Acid exposure in patients with gastroesophageal reflux disease is associated with esophageal dysmotility. ( 30629802 )
2019
15
Are Diet and Micronutrients Effective in Treating Gastroesophageal Reflux Disease Especially in Women? ( 30646473 )
2019
16
Validation of the Korean Version of the Gastroesophageal Reflux Disease Questionnaire for the Diagnosis of Gastroesophageal Reflux Disease. ( 30646480 )
2019
17
Prevalence of Gastroesophageal Reflux Disease Symptoms in Infants and Children: A Systematic Review. ( 30676525 )
2019
18
Detection of laryngeal carcinoma in the U.S. elderly population with gastroesophageal reflux disease. ( 30681216 )
2019
19
Association between tea consumption and gastroesophageal reflux disease: A meta-analysis. ( 30681584 )
2019
20
Melatonin for the treatment of gastroesophageal reflux disease; protocol for a systematic review and meta-analysis. ( 30681611 )
2019
21
Gastroesophageal reflux disease in a patient with BMI 30kg/m2 and previous endoscopic vertical gastroplasty: Indication for a one anastomosis gastric bypass. ( 30683273 )
2019
22
Do patients with gastroesophageal reflux disease and somatoform tendencies benefit from antireflux surgery? ( 30686906 )
2019
23
Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment. ( 30688703 )
2019
24
Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment. ( 30688704 )
2019
25
The impact of gastroesophageal reflux disease symptoms in scleroderma: effects on sleep quality. ( 30715227 )
2019
26
What is this image? 2019: Image 5 result : Gastroesophageal reflux: An unexpected cause of chest pain identified by review of planar images and coregistered SPECT-CT images. ( 30719654 )
2019
27
Laparoscopic total duodenal diversion in the treatment of complex gastroesophageal reflux disease. ( 30772085 )
2019
28
Prevalence and factors associated with gastroesophageal reflux disease in southern India: A community-based study. ( 30790137 )
2019
29
Gastroesophageal reflux disease (GERD). ( 30795847 )
2019
30
Upper Esophageal Sphincter Dysfunction in Gastroesophageal Reflux Disease. ( 30798361 )
2019
31
Management of gastroesophageal reflux disease. ( 30798984 )
2019
32
Natural history, pathophysiology and evaluation of gastroesophageal reflux disease. ( 30803725 )
2019
33
Real-time MRI for the dynamic assessment of fundoplication failure in patients with gastroesophageal reflux disease. ( 30805702 )
2019
34
Minor psychiatric disorders and objective diagnosis of gastroesophageal reflux disease. ( 30815740 )
2019
35
Correction to: Short-Term Symptomatic Relief in Gastroesophageal Reflux Disease: A Comparative Study of Esomeprazole and Vonoprazan. ( 30815827 )
2019
36
Gastroesophageal Reflux Disease in the Neonatal Intensive Care Unit Infant: Who Needs to Be Treated and What Approach Is Beneficial? ( 30819348 )
2019
37
Gastroesophageal Reflux Induces Protein Adducts in the Esophagus. ( 30827415 )
2019
38
Possible application of trefoil factor family peptides in gastroesophageal reflux and Barrett's esophagus. ( 30831146 )
2019
39
Prenatal use of medications for gastroesophageal reflux disease and early childhood fracture risk. ( 30834583 )
2019
40
Similar Effectiveness of Total and 270° Posterior Fundoplication for the Treatment of Gastroesophageal Reflux Disease. ( 30840051 )
2019
41
Comparison of Laparoscopic 270° Posterior Partial Fundoplication vs Total Fundoplication for the Treatment of Gastroesophageal Reflux Disease: A Randomized Clinical Trial. ( 30840057 )
2019
42
A population-based study on prevalence and risk factors of gastroesophageal reflux disease in the Tibet Autonomous Region, China. ( 30842901 )
2019
43
Clinical and psychological characteristics in GERD patients overlapping with laryngopharyngeal reflux symptoms. ( 30851003 )
2019
44
Association between tea consumption and gastroesophageal reflux disease: A meta-analysis: Erratum. ( 30855514 )
2019
45
Relationship Between Torticollis and Gastroesophageal Reflux Disorder in Infants. ( 30865145 )
2019
46
Radiofrequency ablation is safe and effective in the treatment of Chinese patients with gastroesophageal reflux disease: A single-center prospective study. ( 30873743 )
2019
47
Management of Pediatric Gastroesophageal Reflux Disease. ( 30882857 )
2019
48
Vonoprazan versus proton-pump inhibitors for healing gastroesophageal reflux disease: a systematic review. ( 30883868 )
2019
49
Increased risk of larynx cancer in patients with gastroesophageal reflux disease from a national sample cohort. ( 30884136 )
2019
50
Diagnosis and Management of Gastroesophageal Reflux Disease in Infants and Children: from Guidelines to Clinical Practice. ( 30899687 )
2019

Variations for Type Ii Mixed Cryoglobulinemia

Expression for Type Ii Mixed Cryoglobulinemia

Search GEO for disease gene expression data for Type Ii Mixed Cryoglobulinemia.

Pathways for Type Ii Mixed Cryoglobulinemia

Pathways related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 FASLG FN1 HLA-DQB1 HLA-DRB1
2 12.46 FAS FASLG FN1
3
Show member pathways
12.22 FAS FASLG FN1
4
Show member pathways
12.2 FAS FASLG HLA-DQB1 HLA-DRB1
5 11.8 FAS FASLG FN1
6
Show member pathways
11.74 FAS FASLG HLA-DQB1 HLA-DRB1
7
Show member pathways
11.65 FAS FASLG FN1
8 11.53 HLA-DQB1 HLA-DRB1
9
Show member pathways
11.47 FAS FASLG
10 11.4 FAS FASLG
11 11.38 HLA-DQB1 HLA-DRB1
12 11.31 HLA-DQB1 HLA-DRB1
13 11.16 FAS FASLG
14 11.08 FASLG FN1
15 11.05 FAS FASLG
16 10.94 FAS FASLG
17 10.79 CD5 HLA-DQB1 HLA-DRB1

GO Terms for Type Ii Mixed Cryoglobulinemia

Cellular components related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.5 CD5 FASLG HLA-DRB1
2 trans-Golgi network membrane GO:0032588 9.43 HLA-DQB1 HLA-DRB1
3 endocytic vesicle membrane GO:0030666 9.4 HLA-DQB1 HLA-DRB1
4 ER to Golgi transport vesicle membrane GO:0012507 9.37 HLA-DQB1 HLA-DRB1
5 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DRB1
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
8 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 FAS FASLG HLA-DQB1 HLA-DRB1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.52 HLA-DQB1 HLA-DRB1
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.51 FAS FASLG
4 interferon-gamma-mediated signaling pathway GO:0060333 9.49 HLA-DQB1 HLA-DRB1
5 extrinsic apoptotic signaling pathway GO:0097191 9.48 FAS FASLG
6 antigen processing and presentation GO:0019882 9.46 HLA-DQB1 HLA-DRB1
7 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.43 FAS FASLG
8 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.4 FAS FASLG
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.37 HLA-DQB1 HLA-DRB1
10 necroptotic signaling pathway GO:0097527 9.26 FAS FASLG
11 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.16 HLA-DQB1 HLA-DRB1
12 apoptotic signaling pathway GO:0097190 9.13 CD5 FAS FASLG
13 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Type Ii Mixed Cryoglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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