MCID: TYP024
MIFTS: 35

Type Ii Mixed Cryoglobulinemia

Categories: Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases, Immune diseases, Genetic diseases

Aliases & Classifications for Type Ii Mixed Cryoglobulinemia

Summaries for Type Ii Mixed Cryoglobulinemia

MalaCards based summary : Type Ii Mixed Cryoglobulinemia, also known as mc type ii, is related to cryoglobulinemia and cryoglobulinemia, familial mixed. An important gene associated with Type Ii Mixed Cryoglobulinemia is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. Affiliated tissues include bone, b cells and lymph node, and related phenotypes are hematopoietic system and liver/biliary system

Related Diseases for Type Ii Mixed Cryoglobulinemia

Diseases in the Cryoglobulinemia, Familial Mixed family:

Mixed Cryoglobulinemia Type Iii Type Ii Mixed Cryoglobulinemia

Diseases related to Type Ii Mixed Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 cryoglobulinemia 10.7
2 cryoglobulinemia, familial mixed 10.7
3 limbic encephalitis with lgi1 antibodies 10.4 HLA-DQB1 HLA-DRB1
4 metal allergy 10.4 HLA-DQB1 HLA-DRB1
5 hepatitis 10.4
6 focal epithelial hyperplasia 10.4 HLA-DQB1 HLA-DRB1
7 hypersomnia 10.4 HLA-DQB1 HLA-DRB1
8 lichen planopilaris 10.4 HLA-DQB1 HLA-DRB1
9 hepatitis c 10.4
10 beryllium disease 10.4 HLA-DQB1 HLA-DRB1
11 recurrent respiratory papillomatosis 10.4 HLA-DQB1 HLA-DRB1
12 autoimmune pancreatitis 10.4 HLA-DQB1 HLA-DRB1
13 chronic beryllium disease 10.4 HLA-DQB1 HLA-DRB1
14 pityriasis rosea 10.4 HLA-DQB1 HLA-DRB1
15 lichen sclerosus 10.4 HLA-DQB1 HLA-DRB1
16 hepatitis c virus 10.4
17 whipple disease 10.4 HLA-DQB1 HLA-DRB1
18 acute disseminated encephalomyelitis 10.4 HLA-DQB1 HLA-DRB1
19 pediatric multiple sclerosis 10.4 HLA-DQB1 HLA-DRB1
20 osteonecrosis of the jaw 10.4 HLA-DQB1 HLA-DRB1
21 idiopathic bronchiectasis 10.3 HLA-DQB1 HLA-DRB1
22 peanut allergy 10.3 HLA-DQB1 HLA-DRB1
23 oligoarticular juvenile idiopathic arthritis 10.3 HLA-DQB1 HLA-DRB1
24 panuveitis 10.3 HLA-DQB1 HLA-DRB1
25 geographic tongue 10.3 HLA-DQB1 HLA-DRB1
26 severe hemophilia a 10.3 HLA-DQB1 HLA-DRB1
27 ocular cicatricial pemphigoid 10.2 HLA-DQB1 HLA-DRB1
28 paraneoplastic pemphigus 10.2 HLA-DQB1 HLA-DRB1
29 lymphocytic gastritis 10.2 FAS FASLG
30 lymphoma 10.2
31 lymphomatoid papulosis 10.2 FAS FASLG
32 vasculitis 10.1
33 cartilage-hair hypoplasia 10.1 FAS FASLG
34 acute myocarditis 10.1 FAS FASLG
35 idiopathic neutropenia 10.1 FASLG HLA-DRB1
36 rubella 10.1 HLA-DQB1 HLA-DRB1
37 central nervous system tuberculosis 10.1 FAS FASLG
38 epstein-barr virus-associated gastric carcinoma 10.0 FAS FASLG
39 autoimmune lymphoproliferative syndrome, type v 10.0
40 b-cell lymphomas 10.0
41 glomerulonephritis 10.0
42 silicosis 10.0 FAS FASLG
43 severe cutaneous adverse reaction 9.9 FAS FASLG
44 bullous pemphigoid 9.9 HLA-DQB1 HLA-DRB1
45 pneumoconiosis 9.9 FAS FASLG
46 b-cell expansion with nfkb and t-cell anergy 9.9 CD5 FASLG
47 lymphopenia 9.8 FAS FASLG
48 membranoproliferative glomerulonephritis 9.8
49 cerebritis 9.8
50 lymphoma, hodgkin, classic 9.8

Graphical network of the top 20 diseases related to Type Ii Mixed Cryoglobulinemia:



Diseases related to Type Ii Mixed Cryoglobulinemia

Symptoms & Phenotypes for Type Ii Mixed Cryoglobulinemia

MGI Mouse Phenotypes related to Type Ii Mixed Cryoglobulinemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.55 CD5 FAS FASLG FN1 HLA-DQB1
2 liver/biliary system MP:0005370 9.26 FAS FASLG FN1 HLA-DQB1
3 normal MP:0002873 9.02 CD5 FAS FASLG FN1 HLA-DQB1

Drugs & Therapeutics for Type Ii Mixed Cryoglobulinemia

Search Clinical Trials , NIH Clinical Center for Type Ii Mixed Cryoglobulinemia

Genetic Tests for Type Ii Mixed Cryoglobulinemia

Anatomical Context for Type Ii Mixed Cryoglobulinemia

MalaCards organs/tissues related to Type Ii Mixed Cryoglobulinemia:

41
Bone, B Cells, Lymph Node, Bone Marrow, Liver, Brain

Publications for Type Ii Mixed Cryoglobulinemia

Articles related to Type Ii Mixed Cryoglobulinemia:

(show all 48)
# Title Authors Year
1
Scleritis and retinal vasculitis associated with a type II mixed cryoglobulinemia. ( 24259719 )
2013
2
Molecular signatures of hepatitis C virus (HCV)-induced type II mixed cryoglobulinemia (MCII). ( 23202510 )
2012
3
HCV proteins and immunoglobulin variable gene (IgV) subfamilies in HCV-induced type II mixed cryoglobulinemia: a concurrent pathogenetic role. ( 22690241 )
2012
4
Clinical spectrum, treatment, and outcome of patients with type II mixed cryoglobulinemia without evidence of hepatitis C infection. ( 21239761 )
2011
5
Parvovirus B19-induced type II mixed cryoglobulinemia. ( 21854885 )
2011
6
An experimental type II mixed cryoglobulinemia with renal glomerulopathy in ICR mice triggered by Capillaria hepatica infection. ( 21972091 )
2011
7
HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia. ( 20002609 )
2010
8
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. ( 19758144 )
2009
9
Hepatitis C virus-associated type II mixed cryoglobulinemia vasculitis complicated with membranous proliferative glomerulonephritis. ( 19212913 )
2009
10
Essential type II mixed cryoglobulinemia causing pyoderma gangrenosum-like ulcers. ( 18335149 )
2008
11
Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia. ( 17526550 )
2008
12
Efficacy and risk of rituximab in type II mixed cryoglobulinemia: a significant case report. ( 17936216 )
2007
13
Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus. ( 17936227 )
2007
14
The use of monoclonal antibody (rituximab) in the treatment of type II mixed cryoglobulinemia. ( 17625752 )
2007
15
HCV-related immunocytoma and type II mixed cryoglobulinemia-associated autoantigens. ( 17911427 )
2007
16
Paradoxical brain embolism associated with HCV-related type II mixed cryoglobulinemia. ( 17493820 )
2007
17
HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations. ( 16617326 )
2006
18
Efficacy and safety of rituximab in type II mixed cryoglobulinemia. ( 12560225 )
2003
19
Transfusion-associated TT virus co-infection in patients with hepatitis C virus is associated with type II mixed cryoglobulinemia but not with B-cell non-Hodgkin lymphoma. ( 12691541 )
2003
20
Cerebral vasculitis in a patient with HCV-related type II mixed cryoglobulinemia. ( 12968400 )
2003
21
Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia. ( 12175729 )
2002
22
Rituximab for the treatment of type II mixed cryoglobulinemia. ( 12209536 )
2002
23
Severe cutaneous vasculitis following intravenous infusion of gammaglobulin in a patient with type II mixed cryoglobulinemia. ( 12051404 )
2002
24
[Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia]. ( 11769562 )
2001
25
Membranoproliferative glomerulonephritis and demyelinating neuropathy caused by type II mixed cryoglobulinemia associated with HCV infection. ( 10830181 )
2000
26
Peri-lesional injections of granulocyte-macrophage colony-stimulating factor in the management of chronic leg ulcers in type II mixed cryoglobulinemia. ( 10980654 )
2000
27
Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma. ( 10643704 )
2000
28
Splenectomy may improve the glomerulopathy of type II mixed cryoglobulinemia. ( 10845834 )
2000
29
Rituximab for the treatment of type II mixed cryoglobulinemia. ( 10586221 )
1999
30
Lack of Fas and Fas-L mutations in patients with lymphoproliferative disorders associated with SjAPgren's syndrome and type II mixed cryoglobulinemia. ( 10410268 )
1999
31
Asymptomatic type II mixed cryoglobulinemia with a very high cryocrit level secondary to HCV infection. ( 9779567 )
1998
32
Failure of cyclosporin therapy in type II mixed cryoglobulinemia associated with hepatitis C virus infection. ( 9706447 )
1998
33
Interferon for hepatitis C virus-negative type II mixed cryoglobulinemia. ( 9575053 )
1998
34
GB virus C infection in patients with type II mixed cryoglobulinemia. ( 9382367 )
1997
35
Hepatitis C virus genotype analysis in patients with type II mixed cryoglobulinemia. ( 7503475 )
1996
36
Type II mixed cryoglobulinemia treated with fludarabine. ( 8730157 )
1996
37
Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation. ( 8977256 )
1996
38
Low prevalence of hepatitis E virus in type II mixed cryoglobulinemia. ( 8647527 )
1995
39
Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia. ( 7655017 )
1995
40
Lymph node angiogenesis in lymphoproliferative disorders: type II Mixed cryoglobulinemia as a model. ( 8730490 )
1995
41
HLA expression in type II mixed cryoglobulinemia and chronic hepatitis C virus. ( 8730485 )
1995
42
Lymphoproliferation in type II mixed cryoglobulinemia. ( 8730495 )
1995
43
Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection. ( 8730498 )
1995
44
A pilot study on the effectiveness of cyclosporine in type II mixed cryoglobulinemia. ( 8730507 )
1995
45
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. ( 7524736 )
1994
46
Long-term effects of alpha-interferon therapy for type II mixed cryoglobulinemia. ( 7528704 )
1994
47
High prevalence of hepatitis C virus RNA in the supernatant and the cryoprecipitate of patients with essential and secondary type II mixed cryoglobulinemia. ( 7525697 )
1994
48
Hepatitis C virus infection in type II mixed cryoglobulinemia. ( 8216392 )
1993

Variations for Type Ii Mixed Cryoglobulinemia

Expression for Type Ii Mixed Cryoglobulinemia

Search GEO for disease gene expression data for Type Ii Mixed Cryoglobulinemia.

Pathways for Type Ii Mixed Cryoglobulinemia

Pathways related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 FASLG FN1 HLA-DQB1 HLA-DRB1
2 12.44 FAS FASLG FN1
3
Show member pathways
12.3 FAS FASLG HLA-DQB1 HLA-DRB1
4
Show member pathways
11.95 FAS FASLG HLA-DQB1 HLA-DRB1
5 11.8 FAS FASLG FN1
6
Show member pathways
11.55 FAS FASLG FN1
7 11.51 HLA-DQB1 HLA-DRB1
8
Show member pathways
11.46 FAS FASLG
9 11.39 FAS FASLG
10 11.36 HLA-DQB1 HLA-DRB1
11 11.23 HLA-DQB1 HLA-DRB1
12 11.16 FAS FASLG
13 11.08 FASLG FN1
14 11.05 FAS FASLG
15 10.91 FAS FASLG
16 10.79 CD5 HLA-DQB1 HLA-DRB1

GO Terms for Type Ii Mixed Cryoglobulinemia

Cellular components related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network membrane GO:0032588 9.43 HLA-DQB1 HLA-DRB1
2 external side of plasma membrane GO:0009897 9.43 CD5 FASLG HLA-DRB1
3 endocytic vesicle membrane GO:0030666 9.4 HLA-DQB1 HLA-DRB1
4 ER to Golgi transport vesicle membrane GO:0012507 9.37 HLA-DQB1 HLA-DRB1
5 transport vesicle membrane GO:0030658 9.32 HLA-DQB1 HLA-DRB1
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
8 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 FAS FASLG HLA-DQB1 HLA-DRB1
2 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.54 FAS FASLG
3 interferon-gamma-mediated signaling pathway GO:0060333 9.52 HLA-DQB1 HLA-DRB1
4 extrinsic apoptotic signaling pathway GO:0097191 9.51 FAS FASLG
5 antigen processing and presentation GO:0019882 9.49 HLA-DQB1 HLA-DRB1
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.48 FAS FASLG
7 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.46 FAS FASLG
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.43 HLA-DQB1 HLA-DRB1
9 apoptotic signaling pathway GO:0097190 9.43 CD5 FAS FASLG
10 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.4 FAS FASLG
11 necroptotic signaling pathway GO:0097527 9.32 FAS FASLG
12 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.16 HLA-DQB1 HLA-DRB1
13 T cell costimulation GO:0031295 9.13 CD5 HLA-DQB1 HLA-DRB1
14 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Type Ii Mixed Cryoglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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