MCID: TYP007
MIFTS: 66

Typhoid Fever

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Typhoid Fever

MalaCards integrated aliases for Typhoid Fever:

Name: Typhoid Fever 12 53 59 55 3 44 15 73
Typhoid 12 76 53 59
Typhoidal Salmonellosis 59
Enteric Fever 53

Characteristics:

Orphanet epidemiological data:

59
typhoid
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),>1/1000 (South East Asia),1-5/10000 (Latin America),1-5/10000 (Africa),1-9/1000000 (North America),1-5/10000 (Oceania),1-9/1000000 (France); Age of onset: All ages; Age of death: adolescent,late childhood;

Classifications:

Orphanet: 59  
Rare infectious diseases


Summaries for Typhoid Fever

Disease Ontology : 12 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in Salmonella enterica subsp enterica serovar Typhi, which is transmitted by ingestion of food or water contaminated with the feces of an infected person. The infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards based summary : Typhoid Fever, also known as typhoid, is related to aseptic meningitis and hepatitis a, and has symptoms including fever, diarrhea and prostration. An important gene associated with Typhoid Fever is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Azithromycin and Cefixime have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and skin, and related phenotypes are epistaxis and skin rash

CDC : 3 Typhoid fever is a life-threatening illness caused by the bacterium Salmonella Typhi. An estimated 5,700 cases occur each year in the United States.  Most cases (up to 75%) are acquired while traveling internationally. Typhoid fever is still common in the developing world, where it affects about 21.5 million people each year.

Wikipedia : 76 Typhoid fever, also known simply as typhoid, is a bacterial infection due to Salmonella typhi that... more...

Related Diseases for Typhoid Fever

Diseases related to Typhoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 371)
# Related Disease Score Top Affiliating Genes
1 aseptic meningitis 30.3 IFNG IL1B TNF
2 hepatitis a 30.2 ALB F2 TNF
3 neuritis 30.2 IFNG IL1B TNF
4 salmonellosis 30.1 ALB CASP1 IFNG IFNGR1 IL1B SLC11A1
5 legionnaires' disease 30.0 ALB OMP TLR4 TLR5
6 intussusception 30.0 CFTR CRP IL6
7 ileitis 29.9 IL6 TLR4 TLR5 TNF
8 adult respiratory distress syndrome 29.8 F2 IL6 TNF
9 viral hepatitis 29.7 ALB F2 TNF
10 spotted fever 29.7 F2 IFNG TNF
11 pertussis 29.6 IL1B IL6 TLR4 TNF
12 arthritis 29.6 IFNG IL1B IL6 TNF
13 helicobacter pylori infection 29.5 IFNG IFNGR1 IL1B TLR4 TNF
14 purpura 29.2 CRP F2 TNF
15 hepatitis b 29.2 ALB F2 IFNG TNF
16 appendicitis 29.1 ALB CRP IL1B IL6 TNF
17 brucellosis 28.8 CRP IFNG IL6 SLC11A1 TLR4 TNF
18 systemic lupus erythematosus 28.6 ALB CRP IFNG IL6 TLR5 TNF
19 schistosomiasis 28.6 ALB F2 IFNG IFNGR1 TNF
20 hemorrhagic fever 28.5 ALB F2 IFNG IL6 TNF
21 dengue hemorrhagic fever 28.5 ALB F2 IFNG IL6 TNF
22 gastroenteritis 28.4 ALB CRP IFNG IL1B IL6 TNF
23 meningitis 28.2 ALB CRP IFNG IL1B IL6 OMP
24 osteomyelitis 28.2 CASP1 IFNG IFNGR1 IL1B IL6 TNF
25 peritonitis 27.4 ALB CRP F2 IL1B IL6 TNF
26 malaria 26.1 ALB CASP1 CRP IFNG IFNGR1 IL1B
27 typhoidal tularemia 12.1
28 paratyphoid fever 11.5
29 dengue disease 11.3
30 interferon gamma, receptor 1, deficiency 10.9 IFNG IFNGR1
31 scorpion envenomation 10.9 IL6 TNF
32 leukomalacia 10.8 IL6 TNF
33 angioimmunoblastic lymphadenopathy with dysproteinemia 10.8 IL6 TNF
34 trichosporonosis 10.8 IFNG TNF
35 variola major 10.8 IFNG TLR4
36 critical limb ischemia 10.8 IL6 TNF
37 spondylarthropathy 10.7 TLR4 TNF
38 chronic beryllium disease 10.7 IFNG TNF
39 streptococcal toxic-shock syndrome 10.7 IL6 TNF
40 trench fever 10.7 TLR4 TNF
41 null-cell leukemia 10.7 IL6 TNF
42 b-cell growth factor 10.7 IFNG IL6
43 lepromatous leprosy 10.7 IFNG IFNGR1 TNF
44 gastrointestinal tuberculosis 10.7 ALB IFNG
45 leprosy 3 10.7 IFNG SLC11A1 TNF
46 microscopic colitis 10.7 IFNG IL6 TNF
47 meconium aspiration syndrome 10.7 IFNG IL6 TNF
48 systemic onset juvenile idiopathic arthritis 10.7 IL1B TNF
49 intermediate uveitis 10.6 IFNG IL6 TNF
50 hematopoietic stem cell transplantation 10.6 IFNG IL6 TNF

Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to Typhoid Fever

Symptoms & Phenotypes for Typhoid Fever

Symptoms:

12
  • fever
  • diarrhea
  • prostration
  • headache
  • splenomegaly
  • liver enlargement
  • eruption of rose-colored spots
  • leukopenia

Human phenotypes related to Typhoid Fever:

59 32 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 epistaxis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000421
2 skin rash 59 32 frequent (33%) Frequent (79-30%) HP:0000988
3 ataxia 59 32 frequent (33%) Frequent (79-30%) HP:0001251
4 lethargy 59 32 occasional (7.5%) Occasional (29-5%) HP:0001254
5 coma 59 32 occasional (7.5%) Occasional (29-5%) HP:0001259
6 hypertonia 59 32 frequent (33%) Frequent (79-30%) HP:0001276
7 tremor 59 32 occasional (7.5%) Occasional (29-5%) HP:0001337
8 hyperreflexia 59 32 frequent (33%) Frequent (79-30%) HP:0001347
9 cardiac arrest 59 32 occasional (7.5%) Occasional (29-5%) HP:0001695
10 splenomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0001744
11 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
12 diarrhea 59 32 occasional (7.5%) Occasional (29-5%) HP:0002014
13 constipation 59 32 occasional (7.5%) Occasional (29-5%) HP:0002019
14 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
15 gastrointestinal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002239
16 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
17 headache 59 32 hallmark (90%) Very frequent (99-80%) HP:0002315
18 encephalitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002383
19 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
20 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
21 venous thrombosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004936
22 interstitial pulmonary abnormality 59 32 occasional (7.5%) Occasional (29-5%) HP:0006530
23 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
24 macule 59 32 frequent (33%) Frequent (79-30%) HP:0012733
25 cough 59 32 occasional (7.5%) Occasional (29-5%) HP:0012735
26 insomnia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100785
27 arrhythmia 59 Frequent (79-30%)

MGI Mouse Phenotypes related to Typhoid Fever:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 IFNG CFTR CRP ALB F2 CASP1
2 hematopoietic system MP:0005397 10.26 CASP1 IFNG CFTR F2 RHD IL1B
3 digestive/alimentary MP:0005381 10.25 IFNG CFTR ALB F2 CASP1 SLC11A1
4 cardiovascular system MP:0005385 10.24 F2 CASP1 IFNG CRP IFNGR1 IL1B
5 immune system MP:0005387 10.21 CASP1 IFNG CFTR CRP F2 IL1B
6 behavior/neurological MP:0005386 10.2 F2 IFNG CFTR IL6 IFNGR1 OMP
7 cellular MP:0005384 10.18 CASP1 ALB IL6 IFNGR1 OMP IFNG
8 mortality/aging MP:0010768 10.13 CASP1 IFNG CFTR ALB F2 IFNGR1
9 endocrine/exocrine gland MP:0005379 10.1 CASP1 IFNG CFTR ALB IFNGR1 IL6
10 integument MP:0010771 10.01 F2 CASP1 IFNG IFNGR1 IL1B IL6
11 liver/biliary system MP:0005370 9.97 IFNG CFTR ALB IFNGR1 IL6 TLR5
12 neoplasm MP:0002006 9.91 CASP1 IFNG ALB IL1B SLC11A1 TLR4
13 nervous system MP:0003631 9.81 F2 CASP1 IL6 IFNGR1 OMP IL1B
14 reproductive system MP:0005389 9.56 F2 CASP1 IFNG CFTR IFNGR1 IL6
15 respiratory system MP:0005388 9.23 F2 IFNG CFTR OMP IL6 TLR5

Drugs & Therapeutics for Typhoid Fever

Drugs for Typhoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
2
Cefixime Approved, Investigational Phase 4 79350-37-1 54362 5362065
3
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
4
Gatifloxacin Approved, Investigational Phase 4 112811-59-3 5379
5 Anti-Bacterial Agents Phase 4,Phase 3
6 Antibiotics, Antitubercular Phase 4
7 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
8 Antitubercular Agents Phase 4
9 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
10 Fluoroquinolones Phase 4
11 Nucleic Acid Synthesis Inhibitors Phase 4
12 Topoisomerase Inhibitors Phase 4
13
Sulfamethoxazole Approved Phase 3 723-46-6 5329
14
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
15
Lactitol Investigational Phase 3,Phase 2 585-86-4 3871
16 Antiparasitic Agents Phase 3,Phase 1,Phase 2
17 Antiprotozoal Agents Phase 3,Phase 1,Phase 2
18 Antimalarials Phase 3
19 Renal Agents Phase 3
20 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
21
Albendazole Approved, Vet_approved Phase 1, Phase 2 54965-21-8 2082
22
Metronidazole Approved Phase 1, Phase 2 443-48-1 4173
23
Secnidazole Approved Phase 1, Phase 2 3366-95-8
24
Zinc Approved, Investigational Phase 1, Phase 2 7440-66-6 23994
25
Zinc sulfate Approved, Investigational Phase 1, Phase 2 7733-02-0
26
Formaldehyde Approved, Vet_approved Phase 2 50-00-0 712
27
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
28 Antibodies Phase 2,Not Applicable
29 Immunoglobulins Phase 2,Not Applicable
30 Retinol palmitate Phase 2
31 Pharmaceutical Solutions Phase 1, Phase 2,Not Applicable,Early Phase 1
32 Anthelmintics Phase 1, Phase 2
33 Antimitotic Agents Phase 1, Phase 2
34 Astringents Phase 1, Phase 2
35 Dermatologic Agents Phase 1, Phase 2,Not Applicable
36 Micronutrients Phase 1, Phase 2
37 Trace Elements Phase 1, Phase 2
38 Heptavalent Pneumococcal Conjugate Vaccine Phase 2,Phase 1
39 Liver Extracts Phase 1, Phase 2
40 retinol Nutraceutical Phase 2
41 Lecithin Nutraceutical Phase 1, Phase 2,Phase 2
42 Soy Bean Nutraceutical Phase 1, Phase 2,Phase 2
43
Loperamide Approved Phase 1 53179-11-6 3955
44
Pectin Approved, Investigational, Vet_approved Phase 1 9000-69-5 441476
45 Antidiarrheals Phase 1
46 Gastrointestinal Agents Phase 1
47
Cantharidin Approved, Investigational Early Phase 1 56-25-7
48
Ethanol Approved 64-17-5 702
49
BCG vaccine Investigational Not Applicable
50 Complement System Proteins

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Typhoid Fever: Combined vs. Single Antibiotic Therapy Unknown status NCT02224040 Phase 4 ceftriaxone;ceftriaxone and azithromycin;azithromycin;azithromycin and cefixime
2 Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Completed NCT00125008 Phase 4
3 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Completed NCT00131820 Phase 4
4 Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Completed NCT00131833 Phase 4
5 Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Completed NCT00125047 Phase 4
6 Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever Completed NCT01421693 Phase 4 Ceftriaxone;Gatifloxacin
7 Cross-reactive Immunity Elicited by Oral and Parenteral Typhoid Vaccines Recruiting NCT02121145 Phase 4
8 Effects of Aging on Primary and Secondary Vaccine Responses in a 15-Year Longitudinal Cohort Enrolling by invitation NCT03312699 Phase 4
9 Study of a Single Dose of SP093 Typhoid Vi Polysaccharide Vaccine in Japanese Subjects Completed NCT01608815 Phase 3
10 Comparative Study in Healthy Adults Aged 18-50 Yrs Administered With Hepatyrix or Havrix+Typherix or Tiphim Vi, to Compare Reactogenicity & Immunogenicity Completed NCT00197249 Phase 3
11 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3
12 Improving Rotavirus Vaccine Immune Response Completed NCT01825109 Phase 3
13 Clinical Efficacy of Typhoid Conjugate Vaccine (Vi-TCV) Among Children Age 9 Months Through 12 Years in Blantyre, Malawi Recruiting NCT03299426 Phase 3
14 Nepal Undifferentiated Febrile Illness Trial Recruiting NCT02773407 Phase 3 Azithromycin;Co-trimoxazole
15 Dose Ranging Study to Determine the Safety, Reactogenicity and Immunogenicity of Typhoid Fever Vaccine (Ty800) in Healthy Adult Subjects Completed NCT00498654 Phase 2
16 Safety, Immunogenicity and Compatibility With DTP of a Typhoid Fever Vaccine in Infants Completed NCT00342628 Phase 2
17 Immunogenicity, Safety and Tolerability of the Typhoid Fever Vaccine Candidate M01ZH09 in Healthy Adults Completed NCT00679172 Phase 2
18 TY800 Dose Escalation (Typhoid) Completed NCT00269295 Phase 1, Phase 2 Placebo
19 Studies of Immune Responses to Orally Administered Vaccines in Developing Country Completed NCT01019083 Phase 1, Phase 2 Placebo;Placebo;Zinc Sulphate;Albendazole and Secnidazole
20 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Children, Older Infants and Infants Completed NCT01437267 Phase 2
21 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adults, Children, Older Infants and Infants Completed NCT01229176 Phase 2
22 Extension Study of H01_04TP to Evaluate the Booster Response Induced by Vi-CRM197 in Adults Completed NCT01438996 Phase 2
23 Safety and Immunogenicity of Three Formulations of Vi-CRM197 Vaccine Against S. Typhi in Adults (18-40 Years Old) Completed NCT01193907 Phase 2
24 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
25 Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma Patient Completed NCT02338700 Phase 1, Phase 2
26 Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma Patient Completed NCT02338804 Phase 1, Phase 2
27 Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma Patient Completed NCT02338778 Phase 1, Phase 2
28 Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma Patient Completed NCT02338752 Phase 1, Phase 2
29 Safety, Reactogenicity and Immunogenicity of Vi-DT;Typhoid Conjugate Vaccine Recruiting NCT03527355 Phase 2
30 Understanding Typhoid Disease After Vaccination Active, not recruiting NCT01405521 Phase 2
31 Vaccines Against Salmonella Typhi Active, not recruiting NCT02324751 Phase 2
32 Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine in Indonesian Adults, Adolescents, Children and Infants Not yet recruiting NCT03460405 Phase 2
33 Vaccines and Dietary Oats in the Treatment of Ulcerative Colitis Terminated NCT00751933 Phase 2
34 Safety and Immunogenicity of a Vi-DT Typhoid Conjugate Vaccine Completed NCT02645032 Phase 1
35 CVD 909 Vi Prime Boost Study Completed NCT00326443 Phase 1 Placebo
36 Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine Completed NCT00277147 Phase 1 BB IND 6989
37 Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine (Bio Farma) in Adults and Children (Phase I) Completed NCT03109600 Phase 1
38 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adult (18-40 Years Old) Completed NCT01123941 Phase 1
39 Influence of Dietary Nitrate on Vascular Dysfunction and Inflammation Recruiting NCT02715635 Phase 1
40 Effect of Systemic Inflammation on Emotion and Cognition in Patients With Mood Disorder - A Vaccine Study Recruiting NCT03523767 Phase 1
41 Intravesical Ty21a for the Treatment of Patients With Non-muscle-invasive Bladder Cancer (NMIBC) Not yet recruiting NCT03421236 Phase 1
42 Impact of Immune Challenge on Triple Network Connectivity in Humans Unknown status NCT02653235 Not Applicable
43 Causes of Fever in Bangladeshi Patients Unknown status NCT02339259
44 Investigating the Effects of Typhoid Vaccine on Sleep in Healthy Volunteers Completed NCT02628054 Not Applicable
45 Long Term Protection by and Persistence of Vi Antibodies Induced by Vi-rEPA Conjugate Vaccines in Vietnamese Children Injected at 2-5 Years or at 5-8 Years of Age Completed NCT00386789
46 Phase 4 Study To Assess The Safety Of Vivotif At Different Release Titers Among Travelers Completed NCT02391909
47 Investigation of the Influence of Gender on Cardiovascular Function Completed NCT01582321 Early Phase 1 Cantharidin
48 Role of BCG as Booster Vaccination Completed NCT02175420 Not Applicable
49 Exploratory Study on the Mood and Cytokine Levels in Female Healthy Participants and Major Depressive Disorder Patients Completed NCT01533285 Early Phase 1
50 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable

Search NIH Clinical Center for Typhoid Fever

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: typhoid fever

Genetic Tests for Typhoid Fever

Anatomical Context for Typhoid Fever

MalaCards organs/tissues related to Typhoid Fever:

41
Testes, Liver, Skin, Prostate, Bone, Bone Marrow, Colon

Publications for Typhoid Fever

Articles related to Typhoid Fever:

(show top 50) (show all 699)
# Title Authors Year
1
Intestinal perforation due to typhoid fever in Karamoja (Uganda). ( 29848809 )
2018
2
Investigation of a typhoid fever epidemic in Moyale Sub-County, Kenya, 2014-2015. ( 29764520 )
2018
3
Typhoid fever causing haemophagocytic lymphohistiocytosis in a non-endemic country - first case report and review of the current literature. ( 29887216 )
2018
4
The Gathering Storm: Is Untreatable Typhoid Fever on the Way? ( 29559573 )
2018
5
Effectiveness of treatment regimens for Typhoid fever in the nalidixic acid-resistant S. typhi (NARST) era in South India. ( 29495943 )
2018
6
Report of Relapse Typhoid Fever Cases from Kolkata, India: Recrudescence or Reinfection? ( 29709977 )
2018
7
Open label comparative trial of mono versus dual antibiotic therapy for Typhoid Fever in adults. ( 29684022 )
2018
8
Changing trends of culture-positive typhoid fever and antimicrobial susceptibility in a tertiary care North Indian Hospital over the last decade. ( 29735830 )
2018
9
Vaccines for preventing typhoid fever. ( 29851031 )
2018
10
Notes from the Field: Typhoid Fever Outbreak - Harare, Zimbabwe, October 2016-March 2017. ( 29565843 )
2018
11
Comparison of Strategies and Incidence Thresholds for Vi Conjugate Vaccines Against Typhoid Fever: A Cost-effectiveness Modeling Study. ( 29444257 )
2018
12
Development of a bivalent conjugate vaccine candidate against malaria transmission and typhoid fever. ( 29681410 )
2018
13
Epidemiology and risk factors for typhoid fever in Central Division, Fiji, 2014-2017: A case-control study. ( 29883448 )
2018
14
Typhoid Fever due to Extended Spectrum <i>I^</i>-Lactamase-Producing <i>Salmonella enterica</i> Serovar Typhi: A Case Report and Literature Review. ( 29666727 )
2018
15
A Traveler's Disease Without Leaving Home: Typhoid Fever. ( 29410237 )
2018
16
Assessment of water, sanitation and hygiene interventions in response to an outbreak of typhoid fever in Neno District, Malawi. ( 29474394 )
2018
17
Activation of coagulation and endothelium with concurrent impairment of anticoagulant mechanisms in patients with typhoid fever. ( 29746945 )
2018
18
Encephalitis in a traveller with typhoid fever: efficacy of corticosteroids. ( 29088483 )
2017
19
Expression of intra- and extracellular granzymes in patients with typhoid fever. ( 28749963 )
2017
20
Review of current typhoid fever vaccines, cross-protection against paratyphoid fever, and the European guidelines. ( 28856924 )
2017
21
<i>Salmonella</i> Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model. ( 29387052 )
2017
22
Modelling and Optimal Control of Typhoid Fever Disease with Cost-Effective Strategies. ( 29081828 )
2017
23
A large and persistent outbreak of typhoid fever caused by consuming contaminated water and street-vended beverages: Kampala, Uganda, January - June 2015. ( 28056940 )
2017
24
The impact of migration and antimicrobial resistance on the transmission dynamics of typhoid fever in Kathmandu, Nepal: A mathematical modelling study. ( 28475605 )
2017
25
Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia. ( 28130144 )
2017
26
Correction to: A large and persistent outbreak of typhoid fever caused by consuming contaminated water and street-vended beverages: Kampala, Uganda, January - June 2015. ( 29047373 )
2017
27
Detection of typhoid fever by diatom-based optical biosensor. ( 28577141 )
2017
28
Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever. ( 29075261 )
2017
29
Modifiable risk factors for typhoid intestinal perforations during a large outbreak of typhoid fever, Kampala Uganda, 2015. ( 28946853 )
2017
30
A Rare Coincidence of Measles with Typhoid Fever. ( 29104838 )
2017
31
Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol. ( 28827342 )
2017
32
A cross-sectional seroepidemiological survey of typhoid fever in Fiji. ( 28727726 )
2017
33
Development of a synthetic Vi polysaccharide vaccine for typhoid fever. ( 29150208 )
2017
34
Localised transmission hotspots of a typhoid fever outbreak in the Democratic Republic of Congo. ( 29541325 )
2017
35
Comparison of Molecular Detection Method (Nested Polymerase Chain Reaction) with Blood Culture and Paired Widal test for the Rapid Diagnosis of Typhoid Fever. ( 28260765 )
2017
36
Social and Economic Burden Associated With Typhoid Fever in Kathmandu and Surrounding Areas: A Qualitative Study. ( 28973415 )
2017
37
Correction for Alvarez et al., Human genetic variation in<i>VAC14</i>regulates<i>Salmonella</i>invasion and typhoid fever through modulation of cholesterol. ( 29180411 )
2017
38
Typhoid Fever and Acute Appendicitis: A Rare Association Not Yet Fully Formed. ( 29033762 )
2017
39
Environmental Survey of Drinking Water Sources in Kampala, Uganda, during a Typhoid Fever Outbreak. ( 28970225 )
2017
40
Typhoid Fever on the Half Shell. ( 28207076 )
2017
41
An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever. ( 28551371 )
2017
42
Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model. ( 28303138 )
2017
43
Bilateral retinitis following typhoid fever. ( 28405476 )
2017
44
The burden of typhoid fever in low- and middle-income countries: A meta-regression approach. ( 28241011 )
2017
45
Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial. ( 28965718 )
2017
46
Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using a<i>Salmonella</i>Proteome Array. ( 28970824 )
2017
47
Epidemiological characteristics and clinical treatment outcome of typhoid fever in Ningbo China, 2005-2014, PFGE results revealing great proportion of common transmission sources. ( 28367881 )
2017
48
Determination of free polysaccharide in Vi glycoconjugate vaccine against typhoid fever. ( 28282600 )
2017
49
Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa. ( 28483042 )
2017
50
Rhabdomyolysis Complicating Typhoid Fever in a Child and Review of the Literature. ( 28430751 )
2017

Variations for Typhoid Fever

Expression for Typhoid Fever

Search GEO for disease gene expression data for Typhoid Fever.

Pathways for Typhoid Fever

Pathways related to Typhoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 CASP1 CRP IFNG IFNGR1 IL1B IL6
2
Show member pathways
13.65 CASP1 F2 IFNG IFNGR1 IL1B IL6
3
Show member pathways
13 CASP1 IFNG IFNGR1 IL1B IL6 TLR4
4
Show member pathways
12.86 IFNG IFNGR1 IL1B IL6 TNF
5
Show member pathways
12.83 CASP1 IFNG IFNGR1 IL1B IL6 TLR4
6
Show member pathways
12.82 IFNG IFNGR1 IL1B TLR4 TLR5 TNF
7
Show member pathways
12.79 CASP1 IFNG IL1B IL6 TLR4 TNF
8
Show member pathways
12.71 IL1B IL6 TLR4 TLR5 TNF
9
Show member pathways
12.66 IFNG IFNGR1 IL1B IL6 TNF
10
Show member pathways
12.64 IFNG IFNGR1 IL1B TNF
11
Show member pathways
12.61 F2 IFNG IL1B IL6 TNF
12
Show member pathways
12.55 IFNGR1 IL6 TLR4 TNF
13
Show member pathways
12.55 CASP1 IL1B TLR4 TLR5 TNF
14
Show member pathways
12.42 IFNG IL1B IL6 TNF
15
Show member pathways
12.37 IFNG IFNGR1 IL1B IL6 TLR4 TLR5
16
Show member pathways
12.35 CFTR IFNG IL1B IL6 TLR5 TNF
17
Show member pathways
12.31 IFNG IFNGR1 IL1B TLR4 TNF
18
Show member pathways
12.28 IL6 TLR4 TLR5 TNF
19
Show member pathways
12.27 CFTR IL1B IL6 TLR5 TNF
20
Show member pathways
12.23 CASP1 IL1B IL6 TNF
21
Show member pathways
12.23 IFNG IFNGR1 IL1B IL6 TLR4 TNF
22 12.22 IFNG IFNGR1 IL1B IL6 TLR4 TNF
23
Show member pathways
12.2 ALB CRP F2 IFNG IL1B IL6
24
Show member pathways
12.19 CASP1 IFNG IFNGR1 IL1B TLR4 TNF
25 12.13 IFNG IFNGR1 IL6 TLR4 TLR5 TNF
26
Show member pathways
12.1 CASP1 IFNG IFNGR1 IL1B IL6
27 12.08 IFNG IFNGR1 IL1B TNF
28 12.08 IFNG IL1B IL6 TLR4 TNF
29
Show member pathways
12.07 IFNG IFNGR1 IL1B IL6 TLR4 TLR5
30
Show member pathways
12.01 IL1B TLR4 TLR5
31 11.98 IFNG IL6 TNF
32 11.97 IL1B IL6 TNF
33 11.96 IFNG IFNGR1 IL6 TLR4
34 11.94 IL1B IL6 TNF
35 11.94 IFNG IL1B IL6 TLR4 TNF
36 11.93 IFNG IL1B IL6
37 11.9 IL1B IL6 TNF
38 11.88 IL1B IL6 TNF
39 11.88 IFNG IL1B IL6 TLR4 TNF
40 11.87 IL1B TLR4 TNF
41
Show member pathways
11.86 CFTR IL6 TLR4
42 11.81 IFNG IL1B IL6 TNF
43 11.79 IFNG IL1B TNF
44 11.79 CASP1 IL1B IL6 TLR4 TNF
45
Show member pathways
11.73 IFNG IL1B IL6 TNF
46 11.68 IL1B IL6 TNF
47 11.6 IFNG IL1B TLR4 TNF
48 11.58 IFNG IL6 TNF
49
Show member pathways
11.57 IFNG IFNGR1 TNF
50 11.57 IFNG IL1B IL6 TNF

GO Terms for Typhoid Fever

Cellular components related to Typhoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB CRP F2 IFNG IL1B IL6
2 extracellular region GO:0005576 9.23 ALB CASP1 CRP F2 IFNG IL1B

Biological processes related to Typhoid Fever according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.95 SLC11A1 TLR4 TLR5 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.95 CASP1 IFNGR1 IL1B IL6 TNF
3 response to lipopolysaccharide GO:0032496 9.93 CASP1 IL1B SLC11A1 TLR4
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 CASP1 IL1B TLR4 TNF
5 positive regulation of protein phosphorylation GO:0001934 9.9 F2 IFNG IL1B TNF
6 activation of MAPK activity GO:0000187 9.88 IL1B TLR4 TNF
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL1B IL6 TLR4 TNF
8 positive regulation of DNA binding transcription factor activity GO:0051091 9.87 IL1B IL6 TNF
9 response to virus GO:0009615 9.87 IFNG IFNGR1 TNF
10 defense response to Gram-positive bacterium GO:0050830 9.87 CRP IL6 TNF
11 defense response to Gram-negative bacterium GO:0050829 9.86 IL6 SLC11A1 TLR4
12 regulation of inflammatory response GO:0050727 9.85 CASP1 TLR4 TNF
13 positive regulation of JNK cascade GO:0046330 9.83 IL1B TLR4 TNF
14 regulation of insulin secretion GO:0050796 9.83 IFNG IL1B TNF
15 humoral immune response GO:0006959 9.82 IFNG IL6 TNF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 IL1B TLR4 TNF
17 cellular response to mechanical stimulus GO:0071260 9.8 CASP1 IL1B TLR4 TLR5
18 cellular response to lipopolysaccharide GO:0071222 9.8 CASP1 IL6 TLR4 TLR5 TNF
19 inflammatory response GO:0006954 9.8 CRP IL1B IL6 SLC11A1 TLR4 TLR5
20 acute-phase response GO:0006953 9.77 CRP F2 IL6
21 positive regulation of interleukin-6 production GO:0032755 9.76 IL1B IL6 TLR4 TNF
22 positive regulation of phagocytosis GO:0050766 9.75 IL1B SLC11A1 TNF
23 response to bacterium GO:0009617 9.74 CASP1 SLC11A1 TLR4
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 IL1B TLR4 TNF
25 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
26 positive regulation of gene expression GO:0010628 9.7 CRP IFNG IL1B IL6 SLC11A1 TLR4
27 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.69 IFNG IFNGR1
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL1B TNF
29 positive regulation of chemokine production GO:0032722 9.69 IL6 TLR4 TNF
30 regulation of cytokine secretion GO:0050707 9.68 TLR4 TLR5
31 negative regulation of interleukin-17 production GO:0032700 9.68 IFNG TLR4
32 membrane hyperpolarization GO:0060081 9.68 CASP1 CFTR
33 macrophage activation GO:0042116 9.67 SLC11A1 TLR4
34 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
35 positive regulation of interferon-gamma production GO:0032729 9.67 IL1B SLC11A1 TLR4 TNF
36 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.66 TLR4 TNF
37 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
38 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IFNG IL1B TNF
39 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
40 interleukin-1 beta production GO:0032611 9.62 CASP1 IL1B
41 positive regulation of interleukin-8 production GO:0032757 9.62 IL1B TLR4 TLR5 TNF
42 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
43 negative regulation of lipid storage GO:0010888 9.61 CRP IL6 TNF
44 positive regulation of vitamin D biosynthetic process GO:0060557 9.54 IFNG TNF
45 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.13 IFNG IL1B TNF
46 positive regulation of nitric oxide biosynthetic process GO:0045429 9.02 IFNG IL1B TLR4 TLR5 TNF
47 regulation of signaling receptor activity GO:0010469 10.04 F2 IFNG IL1B IL6 TNF
48 immune response GO:0006955 10 IFNG IL1B IL6 SLC11A1 TLR4 TNF

Molecular functions related to Typhoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR5
2 cytokine activity GO:0005125 8.92 IFNG IL1B IL6 TNF

Sources for Typhoid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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37 KEGG
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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