MCID: TYP007
MIFTS: 67

Typhoid Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Typhoid Fever

MalaCards integrated aliases for Typhoid Fever:

Name: Typhoid Fever 12 54 60 56 3 45 15 17 74
Typhoid 12 77 54 60 15
Typhoidal Salmonellosis 60
Enteric Fever 54

Characteristics:

Orphanet epidemiological data:

60
typhoid
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),>1/1000 (South East Asia),1-5/10000 (Latin America),1-5/10000 (Africa),1-9/1000000 (North America),1-5/10000 (Oceania),1-9/1000000 (France); Age of onset: All ages; Age of death: adolescent,late childhood;

Classifications:

Orphanet: 60  
Rare infectious diseases


Summaries for Typhoid Fever

Disease Ontology : 12 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in Salmonella enterica subsp enterica serovar Typhi, which is transmitted by ingestion of food or water contaminated with the feces of an infected person. The infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards based summary : Typhoid Fever, also known as typhoid, is related to paratyphoid fever and salmonellosis, and has symptoms including splenomegaly, fever and headache. An important gene associated with Typhoid Fever is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cefixime and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone marrow, and related phenotypes are fever and fatigue

CDC : 3 Typhoid fever and paratyphoid fever are life-threatening illnesses caused by Salmonella serotype Typhi and Salmonella serotype Paratyphi, respectively.

Wikipedia : 77 Typhoid fever, also known simply as typhoid, is a bacterial infection due to specific type of Salmonella... more...

Related Diseases for Typhoid Fever

Diseases related to Typhoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 508)
# Related Disease Score Top Affiliating Genes
1 paratyphoid fever 32.5 CASP1 CRP IFNGR1
2 salmonellosis 31.5 ALB CASP1 IFNG IFNGR1 IL1B SLC11A1
3 neuritis 30.6 IFNG IL1B TNF
4 cholecystitis 30.6 ALB F2 GPT
5 variola major 30.5 IFNG TLR4
6 pyomyositis 30.4 CRP GPT
7 pleurisy 30.3 CRP IFNG TNF
8 human immunodeficiency virus infectious disease 30.3 IFNG IL6 TNF
9 adult respiratory distress syndrome 30.3 F2 IL6 TNF
10 hepatitis a 30.2 ALB F2 GPT IFNG TNF
11 intussusception 30.2 CFTR CRP IL6
12 peripheral nervous system disease 30.2 ALB IL6 TNF
13 acute respiratory distress syndrome 30.1 IL1B IL6 TNF
14 arthritis 30.1 IFNG IL1B IL6 TNF
15 acute pancreatitis 30.1 CFTR CRP IL6
16 appendicitis 30.0 ALB CRP IL1B IL6 TNF
17 legionnaires' disease 30.0 ALB OMP TLR4 TLR5
18 viral hepatitis 30.0 ALB F2 GPT TNF
19 acute liver failure 29.9 ALB F2 GPT
20 pertussis 29.9 IL1B IL6 TLR4 TNF
21 takayasu arteritis 29.9 CRP IL6 TNF
22 ileitis 29.9 IL6 TLR4 TLR5 TNF
23 osteomyelitis 29.8 IFNG IFNGR1 IL1B IL6 TNF
24 colitis 29.8 IFNG IL1B IL6 TLR4 TNF
25 spotted fever 29.8 F2 IFNG TNF
26 pericarditis 29.8 CRP IFNG IL1B IL6 TNF
27 haemophilus influenzae 29.8 IL1B OMP TNF
28 bone inflammation disease 29.8 CRP IFNG IL1B IL6 TNF
29 aseptic meningitis 29.8 IFNG IL1B TNF
30 purpura 29.7 CRP F2 IL6 TNF
31 viral meningitis 29.7 CRP IFNG IL6
32 septic arthritis 29.7 CRP TLR4 TLR5
33 pyelitis 29.7 CRP IL6 TLR4
34 reactive arthritis 29.7 CRP IFNG OMP TNF
35 meningitis 29.7 ALB CRP IFNG IL1B IL6 OMP
36 intracranial hypertension 29.7 F2 IL1B TNF
37 aplastic anemia 29.7 ALB IFNG IL6 TNF
38 brucellosis 29.6 CRP IFNG IL6 SLC11A1 TLR4 TNF
39 legionellosis 29.6 CASP1 IL1B TLR4 TLR5 TNF
40 toxoplasmosis 29.6 IFNG IL1B IL6 TLR4 TNF
41 pneumonia 29.6 CRP IL1B IL6 TLR4 TLR5 TNF
42 melioidosis 29.5 IFNG IL6 TLR4 TLR5 TNF
43 tonsillitis 29.5 IFNG IL1B IL6 TNF
44 scrub typhus 29.5 CRP GPT IL1B TLR4 TNF
45 cystitis 29.5 CRP IL6 TLR4 TNF
46 schistosomiasis 29.4 ALB F2 IFNG IFNGR1 TNF
47 lymphadenitis 29.4 IFNG IFNGR1 IL1B SLC11A1 TLR4 TNF
48 hepatitis b 29.4 ALB F2 GPT IFNG TNF
49 gastroenteritis 29.4 ALB CRP IL1B IL6 TNF
50 visceral leishmaniasis 29.4 ALB IFNG SLC11A1 TLR4 TNF

Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to Typhoid Fever

Symptoms & Phenotypes for Typhoid Fever

Human phenotypes related to Typhoid Fever:

60 33 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
2 fatigue 60 33 hallmark (90%) Very frequent (99-80%) HP:0012378
3 abdominal pain 60 33 hallmark (90%) Very frequent (99-80%) HP:0002027
4 headache 60 33 hallmark (90%) Very frequent (99-80%) HP:0002315
5 insomnia 60 33 hallmark (90%) Very frequent (99-80%) HP:0100785
6 ataxia 60 33 frequent (33%) Frequent (79-30%) HP:0001251
7 hyperreflexia 60 33 frequent (33%) Frequent (79-30%) HP:0001347
8 splenomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0001744
9 hepatomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0002240
10 hypertonia 60 33 frequent (33%) Frequent (79-30%) HP:0001276
11 arthralgia 60 33 frequent (33%) Frequent (79-30%) HP:0002829
12 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
13 macule 60 33 frequent (33%) Frequent (79-30%) HP:0012733
14 skin rash 60 33 frequent (33%) Frequent (79-30%) HP:0000988
15 tremor 60 33 occasional (7.5%) Occasional (29-5%) HP:0001337
16 constipation 60 33 occasional (7.5%) Occasional (29-5%) HP:0002019
17 encephalitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002383
18 venous thrombosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0004936
19 coma 60 33 occasional (7.5%) Occasional (29-5%) HP:0001259
20 gastrointestinal hemorrhage 60 33 occasional (7.5%) Occasional (29-5%) HP:0002239
21 diarrhea 60 33 occasional (7.5%) Occasional (29-5%) HP:0002014
22 epistaxis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000421
23 cough 60 33 occasional (7.5%) Occasional (29-5%) HP:0012735
24 lethargy 60 33 occasional (7.5%) Occasional (29-5%) HP:0001254
25 cardiac arrest 60 33 occasional (7.5%) Occasional (29-5%) HP:0001695
26 interstitial pulmonary abnormality 60 33 occasional (7.5%) Occasional (29-5%) HP:0006530
27 arrhythmia 60 Frequent (79-30%)

Symptoms:

12
  • splenomegaly
  • fever
  • headache
  • diarrhea
  • leukopenia
  • prostration
  • liver enlargement
  • eruption of rose-colored spots

MGI Mouse Phenotypes related to Typhoid Fever:

47 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.3 CASP1 CRP F2 IFNG IFNGR1 IL1B
2 homeostasis/metabolism MP:0005376 10.29 ALB CASP1 CFTR CRP F2 IFNG
3 digestive/alimentary MP:0005381 10.28 ALB CASP1 CFTR F2 IFNG IFNGR1
4 behavior/neurological MP:0005386 10.27 CFTR F2 IFNG IFNGR1 IL6 OMP
5 cellular MP:0005384 10.25 ALB CASP1 IFNG IFNGR1 IL6 OMP
6 hematopoietic system MP:0005397 10.24 CASP1 CFTR F2 IFNG IFNGR1 IL1B
7 immune system MP:0005387 10.23 CASP1 CFTR CRP F2 IFNG IFNGR1
8 growth/size/body region MP:0005378 10.21 CFTR F2 IFNG IL1B IL6 OMP
9 mortality/aging MP:0010768 10.21 ALB CASP1 CFTR F2 IFNG IFNGR1
10 endocrine/exocrine gland MP:0005379 10.13 ALB CASP1 CFTR IFNG IFNGR1 IL6
11 integument MP:0010771 10.09 CASP1 F2 IFNG IFNGR1 IL1B IL6
12 liver/biliary system MP:0005370 10.01 ALB CFTR IFNG IFNGR1 IL6 TLR4
13 neoplasm MP:0002006 9.97 ALB CASP1 IFNG IFNGR1 IL1B IL6
14 nervous system MP:0003631 9.96 CASP1 F2 IFNG IFNGR1 IL1B IL6
15 reproductive system MP:0005389 9.76 CASP1 CFTR F2 IFNG IFNGR1 IL6
16 respiratory system MP:0005388 9.56 CFTR F2 IFNG IL6 OMP TLR4
17 skeleton MP:0005390 9.23 F2 GPT IFNG IFNGR1 IL1B IL6

Drugs & Therapeutics for Typhoid Fever

Drugs for Typhoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefixime Approved, Investigational Phase 4 79350-37-1 5362065 54362
2
Azithromycin Approved Phase 4,Phase 3 83905-01-5 447043 55185
3
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
4
Gatifloxacin Approved, Investigational Phase 4 112811-59-3 5379
5
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
6 Antitubercular Agents Phase 4
7 Antibiotics, Antitubercular Phase 4
8 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
9 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
10 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
11 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Pharmaceutical Solutions Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1
13 Ophthalmic Solutions Phase 4
14 Topoisomerase Inhibitors Phase 4
15 Trace Elements Phase 4,Phase 1,Phase 2
16 Nutrients Phase 4,Phase 1,Phase 2
17 Micronutrients Phase 4,Phase 1,Phase 2
18 Vitamins Phase 4
19 Antioxidants Phase 4
20 Protective Agents Phase 4
21
Sulfamethoxazole Approved Phase 3 723-46-6 5329
22
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
23
Lactitol Investigational Phase 3,Phase 2 585-88-6, 585-86-4 493591
24 Antiparasitic Agents Phase 3,Phase 1,Phase 2
25 Antiprotozoal Agents Phase 3,Phase 1,Phase 2
26 Anti-Infective Agents, Urinary Phase 3
27 Antimalarials Phase 3
28 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
29 Renal Agents Phase 3
30
Zinc sulfate Approved, Investigational Phase 1, Phase 2 7733-02-0
31
Albendazole Approved, Vet_approved Phase 1, Phase 2 54965-21-8 2082
32
Zinc Approved, Investigational Phase 1, Phase 2 7440-66-6 32051
33
Metronidazole Approved Phase 1, Phase 2 443-48-1 4173
34
Secnidazole Approved Phase 1, Phase 2 3366-95-8
35
Lumefantrine Approved Phase 2 82186-77-4 6437380
36
Artemether Approved Phase 2 71963-77-4 68911 119380
37
Formaldehyde Approved, Vet_approved Phase 2 50-00-0 712
38
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
39 Antibodies Phase 2,Not Applicable
40 retinol Phase 2
41 Retinol palmitate Phase 2
42 Immunoglobulins Phase 2,Not Applicable
43 Dermatologic Agents Phase 1, Phase 2,Not Applicable
44 Anthelmintics Phase 1, Phase 2
45 Antimitotic Agents Phase 1, Phase 2
46 Astringents Phase 1, Phase 2
47 Heptavalent Pneumococcal Conjugate Vaccine Phase 2,Phase 1
48 Soy Bean Phase 1, Phase 2,Phase 2
49 Lecithin Phase 1, Phase 2,Phase 2
50 Liver Extracts Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 73)
# Name Status NCT ID Phase Drugs
1 Typhoid Fever: Combined vs. Single Antibiotic Therapy Unknown status NCT02224040 Phase 4 ceftriaxone;ceftriaxone and azithromycin;azithromycin;azithromycin and cefixime
2 Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Completed NCT00125008 Phase 4
3 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Completed NCT00131820 Phase 4
4 Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Completed NCT00131833 Phase 4
5 Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Completed NCT00125047 Phase 4
6 Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever Completed NCT01421693 Phase 4 Ceftriaxone;Gatifloxacin
7 CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera Recruiting NCT03705585 Phase 4 Vivotif Typhoid Oral Vaccine;Vaxchora
8 Cross-reactive Immunity Elicited by Oral and Parenteral Typhoid Vaccines Recruiting NCT02121145 Phase 4
9 Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation Recruiting NCT03889158 Phase 4
10 Effects of Aging on Primary and Secondary Vaccine Responses in a 15-Year Longitudinal Cohort Active, not recruiting NCT03312699 Phase 4
11 Study of a Single Dose of SP093 Typhoid Vi Polysaccharide Vaccine in Japanese Subjects Completed NCT01608815 Phase 3
12 Comparative Study in Healthy Adults Aged 18-50 Yrs Administered With Hepatyrix or Havrix+Typherix or Tiphim Vi, to Compare Reactogenicity & Immunogenicity Completed NCT00197249 Phase 3
13 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3
14 Improving Rotavirus Vaccine Immune Response Completed NCT01825109 Phase 3
15 Nepal Undifferentiated Febrile Illness Trial Recruiting NCT02773407 Phase 3 Azithromycin;Co-trimoxazole
16 Clinical Efficacy of Typhoid Conjugate Vaccine (Vi-TCV) Among Children Age 9 Months Through 12 Years in Blantyre, Malawi Active, not recruiting NCT03299426 Phase 3
17 Immune Non-inferiority and Safety of a Vi-DT Typhoid Conjugate Vaccine Not yet recruiting NCT03933098 Phase 3
18 Dose Ranging Study to Determine the Safety, Reactogenicity and Immunogenicity of Typhoid Fever Vaccine (Ty800) in Healthy Adult Subjects Completed NCT00498654 Phase 2
19 Safety, Immunogenicity and Compatibility With DTP of a Typhoid Fever Vaccine in Infants Completed NCT00342628 Phase 2
20 Immunogenicity, Safety and Tolerability of the Typhoid Fever Vaccine Candidate M01ZH09 in Healthy Adults Completed NCT00679172 Phase 2
21 TY800 Dose Escalation (Typhoid) Completed NCT00269295 Phase 1, Phase 2 Placebo
22 Studies of Immune Responses to Orally Administered Vaccines in Developing Country Completed NCT01019083 Phase 1, Phase 2 Placebo;Placebo;Zinc Sulphate;Albendazole and Secnidazole
23 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Children, Older Infants and Infants Completed NCT01437267 Phase 2
24 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adults, Children, Older Infants and Infants Completed NCT01229176 Phase 2
25 Extension Study of H01_04TP to Evaluate the Booster Response Induced by Vi-CRM197 in Adults Completed NCT01438996 Phase 2
26 Safety and Immunogenicity of Three Formulations of Vi-CRM197 Vaccine Against S. Typhi in Adults (18-40 Years Old) Completed NCT01193907 Phase 2
27 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
28 Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma Patient Completed NCT02338700 Phase 1, Phase 2
29 Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma Patient Completed NCT02338804 Phase 1, Phase 2
30 Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma Patient Completed NCT02338778 Phase 1, Phase 2
31 Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma Patient Completed NCT02338752 Phase 1, Phase 2
32 Pfs230D1M-EPA/AS01 Vaccine, a Transmission Blocking Vaccine Against Plasmodium Falciparum, in an Age De-Escalation Trial of Children and a Family Compound Trial in Mali Recruiting NCT03917654 Phase 2
33 Typhoid Conjugate Vaccine Trial Among Children Younger Than 2 Years in Ouagadougou, Burkina Faso Active, not recruiting NCT03614533 Phase 2
34 Understanding Typhoid Disease After Vaccination Active, not recruiting NCT01405521 Phase 2
35 Vaccines Against Salmonella Typhi Active, not recruiting NCT02324751 Phase 2
36 Safety, Reactogenicity and Immunogenicity of Vi-DT;Typhoid Conjugate Vaccine Active, not recruiting NCT03527355 Phase 2
37 Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine in Indonesian Adults, Adolescents, Children and Infants Active, not recruiting NCT03460405 Phase 2
38 Vaccines and Dietary Oats in the Treatment of Ulcerative Colitis Terminated NCT00751933 Phase 2
39 Safety and Immunogenicity of a Vi-DT Typhoid Conjugate Vaccine Completed NCT02645032 Phase 1
40 CVD 909 Vi Prime Boost Study Completed NCT00326443 Phase 1 Placebo
41 Safety and Immunogenicity of Typhax, a Typhoid Vaccine Completed NCT03926455 Phase 1
42 Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine Completed NCT00277147 Phase 1 BB IND 6989
43 Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine (Bio Farma) in Adults and Children (Phase I) Completed NCT03109600 Phase 1
44 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adult (18-40 Years Old) Completed NCT01123941 Phase 1
45 Cellular Immune Responses in Typhoid Fever Patients and Vaccinees Recruiting NCT03600025 Phase 1
46 Influence of Dietary Nitrate on Vascular Dysfunction and Inflammation Recruiting NCT02715635 Phase 1
47 Effect of Systemic Inflammation on Emotion and Cognition in Patients With Mood Disorder - A Vaccine Study Recruiting NCT03523767 Phase 1
48 Intravesical Ty21a for the Treatment of Patients With Non-muscle-invasive Bladder Cancer (NMIBC) Recruiting NCT03421236 Phase 1
49 Safety and Tolerability of Typhoid Conjugate Vaccine (EuTCV) in Healthy Adults Active, not recruiting NCT03956524 Phase 1
50 Impact of Immune Challenge on Triple Network Connectivity in Humans Unknown status NCT02653235 Not Applicable

Search NIH Clinical Center for Typhoid Fever

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: typhoid fever

Genetic Tests for Typhoid Fever

Anatomical Context for Typhoid Fever

MalaCards organs/tissues related to Typhoid Fever:

42
Testes, Skin, Bone Marrow, T Cells, Thyroid, Colon, B Cells

Publications for Typhoid Fever

Articles related to Typhoid Fever:

(show top 50) (show all 3935)
# Title Authors Year
1
Typhoid fever complicated by cholecystitis in a 10-year-old boy. ( 30474320 )
2019
2
Prevalence and co-infection of Malaria and Typhoid in the local population of Faisalabad, Pakistan. ( 30829210 )
2019
3
Salmonella Typhi outer membrane protein STIV is a potential candidate for vaccine development against typhoid and paratyphoid fever. ( 30952553 )
2019
4
Typhoid and Paratyphoid Fever - A Call to Action: Erratum. ( 31021958 )
2019
5
In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate. ( 31021700 )
2019
6
Temporal, spatial and household dynamics of Typhoid fever in Kasese district, Uganda. ( 31009473 )
2019
7
Molecular analysis of clonally related Salmonella Typhi recovered from epidemiologically unrelated cases of typhoid fever, Brazil. ( 30849581 )
2019
8
Global Typhoid Fever Incidence: A Systematic Review and Meta-analysis. ( 30845336 )
2019
9
A Review of the Economic Evidence of Typhoid Fever and Typhoid Vaccines. ( 30845334 )
2019
10
Relapse of typhoid fever following delayed response to meropenem: A case report and review of previously published cases indicating limited clinical efficacy of meropenem for the treatment of typhoid fever. ( 30837820 )
2019
11
Extensively drug-resistant typhoid fever in Pakistan. ( 30833059 )
2019
12
Integrating Typhoid Fever Within the Sustainable Development Goals: Pragmatism or Utopia? ( 30767006 )
2019
13
Progress in Typhoid Fever Epidemiology. ( 30767000 )
2019
14
Notes from the Field: Typhoid Fever Outbreak - Harare, Zimbabwe, October 2017-February 2018. ( 30653487 )
2019
15
Typhoid Fever Accompanied With Hematopoetic Lymphohistiocytosis and Rhabdomyolysis in a Refugee Child. ( 30608489 )
2019
16
Travellers take heed: Outbreak of extensively drug resistant (XDR) typhoid fever in Pakistan and a warning from the US CDC. ( 30339826 )
2019
17
Plasma Immunoglobulin A Responses Against 2 Salmonella Typhi Antigens Identify Patients With Typhoid Fever. ( 30020426 )
2019
18
Typhoid fever causing haemophagocytic lymphohistiocytosis in a non-endemic country - first case report and review of the current literature. ( 29887216 )
2019
19
Drug-resistant typhoid epidemic in Pakistan highlights shortcomings of the public health infrastructure. ( 30623938 )
2019
20
Evidence to Action: The 10th International Conference on Typhoid and Other Invasive Salmonelloses. ( 30766998 )
2019
21
A Global Agenda for Typhoid Control-A Perspective from the Bill & Melinda Gates Foundation. ( 30766999 )
2019
22
Revised Global Typhoid Vaccination Policy. ( 30767001 )
2019
23
Overview of the Typhoid Conjugate Vaccine Pipeline: Current Status and Future Plans. ( 30767002 )
2019
24
Typhoid vaccines: WHO position paper, March 2018 - Recommendations. ( 29661581 )
2019
25
Microbiological features of indigenous typhoid cases in Taiwan and relatedness to imported cases, 2001-2014: A cross-sectional analysis. ( 30300755 )
2019
26
Typhoid conjugate vaccines: a new tool in the fight against antimicrobial resistance. ( 30170987 )
2019
27
XDR Typhoid: The Problem And Its Solution. ( 31094103 )
2019
28
Comparative accuracy of typhoid diagnostic tools: A Bayesian latent-class network analysis. ( 31067228 )
2019
29
Draft Genome Sequences of Four Salmonella enterica subsp. enterica Serovar Gallinarum Strains Isolated from Layer Breeder Flocks in an Outbreak of Fowl Typhoid in Colombia. ( 31023811 )
2019
30
Characteristics of regulatory T-cell populations before and after Ty21a typhoid vaccination in children and adults. ( 30953793 )
2019
31
Diversity of Salmonella Typhi-responsive CD4 and CD8 T cells before and after Ty21a typhoid vaccination in children and adults. ( 30951606 )
2019
32
Unique features in the intracellular transport of typhoid toxin revealed by a genome-wide screen. ( 30951565 )
2019
33
Emergence of a highly resistant typhoid strain: a new global health challenge. ( 30882390 )
2019
34
Logistics of Implementing a Large-scale Typhoid Vaccine Trial in Kathmandu, Nepal. ( 30845335 )
2019
35
Assessing the Impact of a Vi-polysaccharide Conjugate Vaccine in Preventing Typhoid Infection Among Bangladeshi Children: A Protocol for a Phase IIIb Trial. ( 30845333 )
2019
36
Incidence of Typhoid and Paratyphoid Fevers Among Adolescents and Adults in Yangon, Myanmar. ( 30845332 )
2019
37
Antibiotic Resistance and Typhoid. ( 30845331 )
2019
38
A Phase II, Randomized, Double-blind, Controlled Safety and Immunogenicity Trial of Typhoid Conjugate Vaccine in Children Under 2 Years of Age in Ouagadougou, Burkina Faso: A Methods Paper. ( 30845330 )
2019
39
Assessing the Impact of a Vi-polysaccharide Conjugate Vaccine in Preventing Typhoid Infections Among Nepalese Children: A Protocol for a Phase III, Randomized Control Trial. ( 30845329 )
2019
40
Accelerating Typhoid Conjugate Vaccine Introduction: What Can Be Learned From Prior New Vaccine Introduction Initiatives? ( 30845328 )
2019
41
The Time is Now to Control Typhoid. ( 30845327 )
2019
42
The Design and Analysis of Seroefficacy Studies for Typhoid Conjugate Vaccines. ( 30845326 )
2019
43
Epidemiology of Typhoid and Paratyphoid: Implications for Vaccine Policy. ( 30845325 )
2019
44
Predicting the Impact of Typhoid Conjugate Vaccines on Antimicrobial Resistance. ( 30845324 )
2019
45
Community Engagement Before Initiation of Typhoid Conjugate Vaccine Trial in Schools in Two Urban Townships in Blantyre, Malawi: Experience and Lessons. ( 30845322 )
2019
46
Forecasting Demand for the Typhoid Conjugate Vaccine in Low- and Middle-income Countries. ( 30845321 )
2019
47
Typhoid Vaccine Acceleration Consortium Malawi: A Phase III, Randomized, Double-blind, Controlled Trial of the Clinical Efficacy of Typhoid Conjugate Vaccine Among Children in Blantyre, Malawi. ( 30845320 )
2019
48
The Coalition Against Typhoid: Mobilizing a Community for a Global Fight. ( 30845319 )
2019
49
The global burden of enteric fevers in the age of typhoid-conjugate vaccines. ( 30792132 )
2019
50
The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017. ( 30792131 )
2019

Variations for Typhoid Fever

Expression for Typhoid Fever

Search GEO for disease gene expression data for Typhoid Fever.

Pathways for Typhoid Fever

Pathways related to Typhoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CASP1 CRP IFNG IFNGR1 IL1B IL6
2
Show member pathways
13.65 CASP1 F2 IFNG IFNGR1 IL1B IL6
3
Show member pathways
13.19 IFNG IFNGR1 IL1B TLR4 TLR5 TNF
4
Show member pathways
13.1 CASP1 IFNG IFNGR1 IL1B IL6 TLR4
5
Show member pathways
12.86 IFNG IFNGR1 IL1B IL6 TNF
6
Show member pathways
12.79 CASP1 IFNG IL1B IL6 TLR4 TNF
7
Show member pathways
12.71 IL1B IL6 TLR4 TLR5 TNF
8
Show member pathways
12.63 CASP1 IL1B TLR4 TLR5 TNF
9
Show member pathways
12.6 F2 IFNG IL1B IL6 TNF
10
Show member pathways
12.56 IFNG IFNGR1 IL1B IL6 TLR4 TLR5
11
Show member pathways
12.55 IFNG IL1B IL6 TNF
12
Show member pathways
12.37 IFNG IFNGR1 IL1B IL6 TLR4 TNF
13
Show member pathways
12.35 CFTR IFNG IL1B IL6 TLR5 TNF
14
Show member pathways
12.3 IFNG IFNGR1 IL1B TLR4 TNF
15
Show member pathways
12.28 IL6 TLR4 TLR5 TNF
16
Show member pathways
12.27 CFTR IL1B IL6 TLR5 TNF
17
Show member pathways
12.25 IFNG IL1B IL6 TNF
18
Show member pathways
12.22 CASP1 IL1B IL6 TNF
19 12.22 IFNG IFNGR1 IL1B IL6 TLR4 TNF
20
Show member pathways
12.2 ALB CRP F2 IFNG IL1B IL6
21
Show member pathways
12.17 CASP1 IFNG IFNGR1 IL1B TLR4 TNF
22 12.13 IFNG IFNGR1 IL6 TLR4 TLR5 TNF
23
Show member pathways
12.09 CASP1 IFNG IFNGR1 IL1B IL6
24 12.08 IFNG IFNGR1 IL1B TNF
25 12.08 IFNG IL1B IL6 TLR4 TNF
26
Show member pathways
12.01 IL1B TLR4 TLR5
27 11.97 IFNG IL6 TNF
28 11.97 IL1B IL6 TNF
29 11.96 IFNG IFNGR1 IL6 TLR4
30 11.95 IL1B IL6 TNF
31
Show member pathways
11.95 F2 IFNG IL1B IL6 TLR4 TNF
32 11.94 IFNG IL1B IL6 TLR4 TNF
33 11.93 IFNG IL1B IL6
34
Show member pathways
11.91 IFNG IFNGR1 IL1B IL6 TLR4 TLR5
35 11.9 IL1B IL6 TNF
36 11.89 IL1B TLR4 TNF
37 11.88 IL1B IL6 TNF
38 11.88 IFNG IL1B IL6 TLR4 TNF
39
Show member pathways
11.86 CFTR IL6 TLR4
40 11.81 IFNG IL1B IL6 TNF
41 11.79 IFNG IL1B TNF
42 11.79 IFNG IL1B IL6 TNF
43 11.79 CASP1 IL1B IL6 TLR4 TNF
44
Show member pathways
11.73 IFNG IL1B IL6 TNF
45 11.68 IL1B IL6 TNF
46 11.6 IFNG IL1B TLR4 TNF
47 11.58 IFNG IL6 TNF
48
Show member pathways
11.57 IFNG IFNGR1 TNF
49 11.57 IFNG IL1B IL6 TNF
50 11.55 IL1B IL6 TNF

GO Terms for Typhoid Fever

Cellular components related to Typhoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome membrane GO:0010008 9.26 CFTR SLC11A1 TLR4 VAC14
2 extracellular space GO:0005615 9.23 ALB CRP F2 GPT IFNG IL1B

Biological processes related to Typhoid Fever according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.97 SLC11A1 TLR4 TLR5 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.97 CASP1 IFNGR1 IL1B IL6 TNF
3 positive regulation of protein phosphorylation GO:0001934 9.93 F2 IFNG IL1B TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 CASP1 IL1B TLR4 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 IL1B IL6 TLR4 TNF
6 positive regulation of gene expression GO:0010628 9.91 CRP IFNG IL1B IL6 SLC11A1 TLR4
7 activation of MAPK activity GO:0000187 9.88 IL1B TLR4 TNF
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 IL1B IL6 TNF
9 response to virus GO:0009615 9.87 IFNG IFNGR1 TNF
10 defense response to Gram-positive bacterium GO:0050830 9.86 CRP IL6 TNF
11 defense response to Gram-negative bacterium GO:0050829 9.85 IL6 SLC11A1 TLR4
12 positive regulation of JNK cascade GO:0046330 9.85 IL1B TLR4 TNF
13 regulation of insulin secretion GO:0050796 9.84 IFNG IL1B TNF
14 apoptotic signaling pathway GO:0097190 9.83 CASP1 TLR4 TNF
15 cellular response to mechanical stimulus GO:0071260 9.83 CASP1 IL1B TLR4 TLR5
16 humoral immune response GO:0006959 9.82 IFNG IL6 TNF
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 IL1B TLR4 TNF
18 inflammatory response GO:0006954 9.8 CRP IL1B IL6 SLC11A1 TLR4 TLR5
19 positive regulation of interleukin-6 production GO:0032755 9.78 IL1B IL6 TLR4 TNF
20 positive regulation of phagocytosis GO:0050766 9.77 IL1B SLC11A1 TNF
21 acute-phase response GO:0006953 9.77 CRP F2 IL6
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 IL1B TLR4 TNF
23 negative regulation of neurogenesis GO:0050768 9.73 IL1B IL6 TNF
24 positive regulation of interferon-gamma production GO:0032729 9.73 IL1B SLC11A1 TLR4 TNF
25 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
26 positive regulation of chemokine production GO:0032722 9.71 IL6 TLR4 TNF
27 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL1B TNF
29 regulation of cytokine secretion GO:0050707 9.69 TLR4 TLR5
30 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.69 IFNG IFNGR1
31 positive regulation of glial cell proliferation GO:0060252 9.69 IL1B IL6 TNF
32 negative regulation of interleukin-17 production GO:0032700 9.68 IFNG TLR4
33 macrophage activation GO:0042116 9.68 SLC11A1 TLR4
34 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 TLR4 TNF
35 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 IFNG IL1B TNF
37 response to glucocorticoid GO:0051384 9.66 IL6 TNF
38 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
39 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
40 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 TNF
41 positive regulation of interleukin-8 production GO:0032757 9.62 IL1B TLR4 TLR5 TNF
42 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
43 positive regulation of neuroinflammatory response GO:0150078 9.58 IL1B IL6 TNF
44 positive regulation of vitamin D biosynthetic process GO:0060557 9.57 IFNG TNF
45 cellular response to lipopolysaccharide GO:0071222 9.43 CASP1 IL1B IL6 TLR4 TLR5 TNF
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.33 IFNG IL1B TNF
47 chronic inflammatory response to antigenic stimulus GO:0002439 9.32 TNF
48 positive regulation of nitric oxide biosynthetic process GO:0045429 9.02 IFNG IL1B TLR4 TLR5 TNF
49 regulation of signaling receptor activity GO:0010469 10.04 F2 IFNG IL1B IL6 TNF
50 immune response GO:0006955 10.02 IFNG IL1B IL6 SLC11A1 TLR4 TNF

Molecular functions related to Typhoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR5
2 cytokine activity GO:0005125 8.92 IFNG IL1B IL6 TNF

Sources for Typhoid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
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45 MeSH
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63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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