MCID: TYP007
MIFTS: 67

Typhoid Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Typhoid Fever

MalaCards integrated aliases for Typhoid Fever:

Name: Typhoid Fever 12 53 59 55 3 44 15 73
Typhoid 12 76 53 59 15
Typhoidal Salmonellosis 59
Enteric Fever 53

Characteristics:

Orphanet epidemiological data:

59
typhoid
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),>1/1000 (South East Asia),1-5/10000 (Latin America),1-5/10000 (Africa),1-9/1000000 (North America),1-5/10000 (Oceania),1-9/1000000 (France); Age of onset: All ages; Age of death: adolescent,late childhood;

Classifications:

Orphanet: 59  
Rare infectious diseases


Summaries for Typhoid Fever

Disease Ontology : 12 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in Salmonella enterica subsp enterica serovar Typhi, which is transmitted by ingestion of food or water contaminated with the feces of an infected person. The infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards based summary : Typhoid Fever, also known as typhoid, is related to paratyphoid fever and salmonellosis, and has symptoms including splenomegaly, fever and diarrhea. An important gene associated with Typhoid Fever is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Azithromycin and Cefixime have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and skin, and related phenotypes are ataxia and tremor

CDC : 3 Typhoid fever and paratyphoid fever are life-threatening illnesses caused by Salmonella serotype Typhi and Salmonella serotype Paratyphi, respectively.

Wikipedia : 76 Typhoid fever, also known simply as typhoid, is a bacterial infection due to Salmonella typhi that... more...

Related Diseases for Typhoid Fever

Diseases related to Typhoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 462)
# Related Disease Score Top Affiliating Genes
1 paratyphoid fever 32.4 CASP1 CRP IFNGR1
2 salmonellosis 31.8 ALB CASP1 IFNG IFNGR1 IL1B SLC11A1
3 hepatitis a 30.5 ALB F2 IFNG TNF
4 viral hepatitis 30.3 ALB F2 TNF
5 adult respiratory distress syndrome 30.2 F2 IL6 TNF
6 pleurisy 30.2 CRP IFNG TNF
7 acute pancreatitis 30.1 CFTR CRP IL6
8 human immunodeficiency virus infectious disease 30.1 IFNG IL6 TNF
9 legionnaires' disease 30.1 ALB OMP TLR4 TLR5
10 neuritis 30.1 IFNG IL1B TNF
11 intussusception 30.0 CFTR CRP IL6
12 ileitis 29.9 IL6 TLR4 TLR5 TNF
13 spotted fever 29.9 F2 IFNG TNF
14 hepatitis b 29.8 ALB F2 IFNG TNF
15 aseptic meningitis 29.8 IFNG IL1B TNF
16 appendicitis 29.8 ALB CRP IL1B IL6 TNF
17 brucellosis 29.8 CRP IFNG IL6 SLC11A1 TLR4 TNF
18 scrub typhus 29.8 CRP IL1B TLR4 TNF
19 takayasu arteritis 29.8 CRP IL6 TNF
20 pertussis 29.8 IL1B IL6 TLR4 TNF
21 viral infectious disease 29.7 IFNG IL1B IL6 TNF
22 viral meningitis 29.7 CRP IFNG IL6
23 osteomyelitis 29.7 IFNG IFNGR1 IL1B IL6 TNF
24 legionellosis 29.7 CASP1 IL1B TLR4 TLR5 TNF
25 pyelitis 29.7 CRP IL6 TLR4
26 meningitis 29.7 ALB CRP IFNG IL1B IL6 OMP
27 acute respiratory distress syndrome 29.7 IL1B IL6 LTA TNF
28 hepatitis e 29.6 ALB F2 IFNG TNF
29 lymphadenitis 29.6 IFNG IFNGR1 IL1B SLC11A1 TLR4 TNF
30 reactive arthritis 29.6 CRP IFNG OMP TNF
31 colitis 29.6 IFNG IL1B IL6 TLR4 TNF
32 gastroenteritis 29.6 ALB CRP IL1B IL6 TNF
33 melioidosis 29.6 IFNG IL6 TLR4 TLR5 TNF
34 arthritis 29.6 IFNG IL1B IL6 LTA TNF
35 purpura 29.5 CRP F2 IL6 TNF
36 pneumonia 29.5 CRP IL1B IL6 TLR4 TLR5 TNF
37 malaria 29.5 ALB CASP1 CRP IFNG IFNGR1 IL1B
38 schistosomiasis 29.4 ALB F2 IFNG IFNGR1 TNF
39 hemorrhagic fever 29.4 ALB F2 IFNG IL6 TNF
40 dengue hemorrhagic fever 29.4 ALB F2 IFNG IL6 TNF
41 toxoplasmosis 29.4 IFNG IL1B IL6 TLR4 TNF
42 bone inflammation disease 29.4 CRP IFNG IL1B IL6 TNF
43 bronchitis 29.4 ALB CFTR CRP TNF
44 endocarditis 29.3 ALB CRP F2 IL6 TNF
45 tonsillitis 29.3 IFNG IL1B IL6 LTA TNF
46 aplastic anemia 29.2 ALB IFNG IL6 LTA TNF
47 peritonitis 29.1 ALB CRP F2 IL1B IL6 TNF
48 intestinal disease 29.1 ALB CRP IL1B IL6 TLR4 TNF
49 leptospirosis 29.0 CRP F2 IFNG IL1B IL6 TNF
50 behcet syndrome 28.9 CRP IFNG IL1B IL6 LTA TLR4

Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to Typhoid Fever

Symptoms & Phenotypes for Typhoid Fever

Symptoms:

12
  • splenomegaly
  • fever
  • diarrhea
  • headache
  • leukopenia
  • prostration
  • liver enlargement
  • eruption of rose-colored spots

Human phenotypes related to Typhoid Fever:

59 32 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ataxia 59 32 frequent (33%) Frequent (79-30%) HP:0001251
2 tremor 59 32 occasional (7.5%) Occasional (29-5%) HP:0001337
3 hyperreflexia 59 32 frequent (33%) Frequent (79-30%) HP:0001347
4 constipation 59 32 occasional (7.5%) Occasional (29-5%) HP:0002019
5 encephalitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002383
6 splenomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0001744
7 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
8 hypertonia 59 32 frequent (33%) Frequent (79-30%) HP:0001276
9 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
10 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
11 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
12 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
13 venous thrombosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004936
14 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
15 coma 59 32 occasional (7.5%) Occasional (29-5%) HP:0001259
16 gastrointestinal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002239
17 diarrhea 59 32 occasional (7.5%) Occasional (29-5%) HP:0002014
18 epistaxis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000421
19 macule 59 32 frequent (33%) Frequent (79-30%) HP:0012733
20 skin rash 59 32 frequent (33%) Frequent (79-30%) HP:0000988
21 cough 59 32 occasional (7.5%) Occasional (29-5%) HP:0012735
22 insomnia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100785
23 lethargy 59 32 occasional (7.5%) Occasional (29-5%) HP:0001254
24 headache 59 32 hallmark (90%) Very frequent (99-80%) HP:0002315
25 cardiac arrest 59 32 occasional (7.5%) Occasional (29-5%) HP:0001695
26 interstitial pulmonary abnormality 59 32 occasional (7.5%) Occasional (29-5%) HP:0006530
27 arrhythmia 59 Frequent (79-30%)

GenomeRNAi Phenotypes related to Typhoid Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CASP1 CFTR F2 IL1B LTA TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CASP1 CFTR F2 IL1B LTA TNF

MGI Mouse Phenotypes related to Typhoid Fever:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 CASP1 CRP F2 IFNG IFNGR1 IL1B
2 homeostasis/metabolism MP:0005376 10.32 ALB CASP1 CFTR CRP F2 IFNG
3 behavior/neurological MP:0005386 10.31 CFTR F2 IFNG IFNGR1 IL6 LTA
4 digestive/alimentary MP:0005381 10.28 ALB CASP1 CFTR F2 IFNG IFNGR1
5 hematopoietic system MP:0005397 10.27 CASP1 CFTR F2 IFNG IFNGR1 IL1B
6 immune system MP:0005387 10.27 CASP1 CFTR CRP F2 IFNG IFNGR1
7 cellular MP:0005384 10.25 ALB CASP1 IFNG IFNGR1 IL6 OMP
8 growth/size/body region MP:0005378 10.25 CFTR F2 IFNG IL1B IL6 LTA
9 mortality/aging MP:0010768 10.24 ALB CASP1 CFTR F2 IFNG IFNGR1
10 endocrine/exocrine gland MP:0005379 10.18 ALB CASP1 CFTR IFNG IFNGR1 IL6
11 integument MP:0010771 10.09 CASP1 F2 IFNG IFNGR1 IL1B IL6
12 liver/biliary system MP:0005370 10.06 ALB CFTR IFNG IFNGR1 IL6 LTA
13 nervous system MP:0003631 10 CASP1 F2 IFNG IFNGR1 IL1B IL6
14 neoplasm MP:0002006 9.97 ALB CASP1 IFNG IFNGR1 IL1B IL6
15 reproductive system MP:0005389 9.76 CASP1 CFTR F2 IFNG IFNGR1 IL6
16 respiratory system MP:0005388 9.61 CFTR F2 IFNG IL6 LTA OMP
17 skeleton MP:0005390 9.23 F2 IFNG IFNGR1 IL1B IL6 LTA

Drugs & Therapeutics for Typhoid Fever

Drugs for Typhoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
2
Cefixime Approved, Investigational Phase 4 79350-37-1 5362065 54362
3
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
4
Gatifloxacin Approved, Investigational Phase 4 112811-59-3 5379
5 Antibiotics, Antitubercular Phase 4
6 Anti-Bacterial Agents Phase 4,Phase 3
7 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
8 Antitubercular Agents Phase 4
9 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
10 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
11 Topoisomerase Inhibitors Phase 4
12 Fluoroquinolones Phase 4
13 Nucleic Acid Synthesis Inhibitors Phase 4
14
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
15
Sulfamethoxazole Approved Phase 3 723-46-6 5329
16
Lactitol Investigational Phase 3,Phase 2 585-86-4 3871
17 Antiprotozoal Agents Phase 3,Phase 1,Phase 2
18 Antiparasitic Agents Phase 3,Phase 1,Phase 2
19 Renal Agents Phase 3
20 Anti-Infective Agents, Urinary Phase 3
21 Antimalarials Phase 3
22 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
23
Zinc Approved, Investigational Phase 1, Phase 2 7440-66-6
24
Albendazole Approved, Vet_approved Phase 1, Phase 2 54965-21-8 2082
25
Secnidazole Approved Phase 1, Phase 2 3366-95-8
26
Zinc sulfate Approved, Investigational Phase 1, Phase 2 7733-02-0
27
Metronidazole Approved Phase 1, Phase 2 443-48-1 4173
28
Formaldehyde Approved, Vet_approved Phase 2 50-00-0 712
29
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
30 Pharmaceutical Solutions Phase 1, Phase 2,Phase 2,Not Applicable,Early Phase 1
31 Retinol palmitate Phase 2
32 Immunoglobulins Phase 2,Not Applicable
33 Antibodies Phase 2,Not Applicable
34 retinol Phase 2
35 Trace Elements Phase 1, Phase 2
36 Micronutrients Phase 1, Phase 2
37 Antimitotic Agents Phase 1, Phase 2
38 Astringents Phase 1, Phase 2
39 Anthelmintics Phase 1, Phase 2
40 Dermatologic Agents Phase 1, Phase 2,Not Applicable
41 Heptavalent Pneumococcal Conjugate Vaccine Phase 2,Phase 1
42 Soy Bean Phase 1, Phase 2,Phase 2
43 Lecithin Phase 1, Phase 2,Phase 2
44 Liver Extracts Phase 1, Phase 2
45
Pectin Approved, Investigational, Vet_approved Phase 1 9000-69-5 441476
46
Loperamide Approved Phase 1 53179-11-6 3955
47 Antidiarrheals Phase 1
48 Gastrointestinal Agents Phase 1
49
Cantharidin Approved, Investigational Early Phase 1 56-25-7
50
Ethanol Approved 64-17-5 702

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Typhoid Fever: Combined vs. Single Antibiotic Therapy Unknown status NCT02224040 Phase 4 ceftriaxone;ceftriaxone and azithromycin;azithromycin;azithromycin and cefixime
2 Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Completed NCT00125008 Phase 4
3 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Completed NCT00131820 Phase 4
4 Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Completed NCT00131833 Phase 4
5 Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Completed NCT00125047 Phase 4
6 Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever Completed NCT01421693 Phase 4 Ceftriaxone;Gatifloxacin
7 CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera Recruiting NCT03705585 Phase 4 Vivotif Typhoid Oral Vaccine;Vaxchora
8 Cross-reactive Immunity Elicited by Oral and Parenteral Typhoid Vaccines Recruiting NCT02121145 Phase 4
9 Effects of Aging on Primary and Secondary Vaccine Responses in a 15-Year Longitudinal Cohort Enrolling by invitation NCT03312699 Phase 4
10 Study of a Single Dose of SP093 Typhoid Vi Polysaccharide Vaccine in Japanese Subjects Completed NCT01608815 Phase 3
11 Comparative Study in Healthy Adults Aged 18-50 Yrs Administered With Hepatyrix or Havrix+Typherix or Tiphim Vi, to Compare Reactogenicity & Immunogenicity Completed NCT00197249 Phase 3
12 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3
13 Improving Rotavirus Vaccine Immune Response Completed NCT01825109 Phase 3
14 Nepal Undifferentiated Febrile Illness Trial Recruiting NCT02773407 Phase 3 Azithromycin;Co-trimoxazole
15 Clinical Efficacy of Typhoid Conjugate Vaccine (Vi-TCV) Among Children Age 9 Months Through 12 Years in Blantyre, Malawi Active, not recruiting NCT03299426 Phase 3
16 Dose Ranging Study to Determine the Safety, Reactogenicity and Immunogenicity of Typhoid Fever Vaccine (Ty800) in Healthy Adult Subjects Completed NCT00498654 Phase 2
17 Safety, Immunogenicity and Compatibility With DTP of a Typhoid Fever Vaccine in Infants Completed NCT00342628 Phase 2
18 Immunogenicity, Safety and Tolerability of the Typhoid Fever Vaccine Candidate M01ZH09 in Healthy Adults Completed NCT00679172 Phase 2
19 TY800 Dose Escalation (Typhoid) Completed NCT00269295 Phase 1, Phase 2 Placebo
20 Studies of Immune Responses to Orally Administered Vaccines in Developing Country Completed NCT01019083 Phase 1, Phase 2 Placebo;Placebo;Zinc Sulphate;Albendazole and Secnidazole
21 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Children, Older Infants and Infants Completed NCT01437267 Phase 2
22 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adults, Children, Older Infants and Infants Completed NCT01229176 Phase 2
23 Extension Study of H01_04TP to Evaluate the Booster Response Induced by Vi-CRM197 in Adults Completed NCT01438996 Phase 2
24 Safety and Immunogenicity of Three Formulations of Vi-CRM197 Vaccine Against S. Typhi in Adults (18-40 Years Old) Completed NCT01193907 Phase 2
25 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
26 Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma Patient Completed NCT02338700 Phase 1, Phase 2
27 Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma Patient Completed NCT02338804 Phase 1, Phase 2
28 Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma Patient Completed NCT02338778 Phase 1, Phase 2
29 Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma Patient Completed NCT02338752 Phase 1, Phase 2
30 Typhoid Conjugate Vaccine Trial Among Children Younger Than 2 Years in Ouagadougou, Burkina Faso Recruiting NCT03614533 Phase 2
31 Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine in Indonesian Adults, Adolescents, Children and Infants Recruiting NCT03460405 Phase 2
32 Understanding Typhoid Disease After Vaccination Active, not recruiting NCT01405521 Phase 2
33 Vaccines Against Salmonella Typhi Active, not recruiting NCT02324751 Phase 2
34 Safety, Reactogenicity and Immunogenicity of Vi-DT;Typhoid Conjugate Vaccine Active, not recruiting NCT03527355 Phase 2
35 Vaccines and Dietary Oats in the Treatment of Ulcerative Colitis Terminated NCT00751933 Phase 2
36 Influence of Dietary Nitrate on Vascular Dysfunction and Inflammation Unknown status NCT02715635 Phase 1
37 Safety and Immunogenicity of a Vi-DT Typhoid Conjugate Vaccine Completed NCT02645032 Phase 1
38 CVD 909 Vi Prime Boost Study Completed NCT00326443 Phase 1 Placebo
39 Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine Completed NCT00277147 Phase 1 BB IND 6989
40 Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine (Bio Farma) in Adults and Children (Phase I) Completed NCT03109600 Phase 1
41 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adult (18-40 Years Old) Completed NCT01123941 Phase 1
42 Cellular Immune Responses in Typhoid Fever Patients and Vaccinees Recruiting NCT03600025 Phase 1
43 Effect of Systemic Inflammation on Emotion and Cognition in Patients With Mood Disorder - A Vaccine Study Recruiting NCT03523767 Phase 1
44 Intravesical Ty21a for the Treatment of Patients With Non-muscle-invasive Bladder Cancer (NMIBC) Not yet recruiting NCT03421236 Phase 1
45 Impact of Immune Challenge on Triple Network Connectivity in Humans Unknown status NCT02653235 Not Applicable
46 Investigating the Effects of Typhoid Vaccine on Sleep in Healthy Volunteers Completed NCT02628054 Not Applicable
47 Long Term Protection by and Persistence of Vi Antibodies Induced by Vi-rEPA Conjugate Vaccines in Vietnamese Children Injected at 2-5 Years or at 5-8 Years of Age Completed NCT00386789
48 Phase 4 Study To Assess The Safety Of Vivotif At Different Release Titers Among Travelers Completed NCT02391909
49 Investigation of the Influence of Gender on Cardiovascular Function Completed NCT01582321 Early Phase 1 Cantharidin
50 Role of BCG as Booster Vaccination Completed NCT02175420 Not Applicable

Search NIH Clinical Center for Typhoid Fever

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: typhoid fever

Genetic Tests for Typhoid Fever

Anatomical Context for Typhoid Fever

MalaCards organs/tissues related to Typhoid Fever:

41
Testes, Liver, Skin, Bone, Bone Marrow, T Cells, Thyroid

Publications for Typhoid Fever

Articles related to Typhoid Fever:

(show top 50) (show all 1475)
# Title Authors Year
1
Raman spectroscopy based differentiation of typhoid and dengue fever in infected human sera. ( 30114579 )
2019
2
Intestinal perforation due to typhoid fever in Karamoja (Uganda). ( 29848809 )
2018
3
Investigation of a typhoid fever epidemic in Moyale Sub-County, Kenya, 2014-2015. ( 29764520 )
2018
4
Typhoid fever causing haemophagocytic lymphohistiocytosis in a non-endemic country - first case report and review of the current literature. ( 29887216 )
2018
5
The Gathering Storm: Is Untreatable Typhoid Fever on the Way? ( 29559573 )
2018
6
Effectiveness of treatment regimens for Typhoid fever in the nalidixic acid-resistant S. typhi (NARST) era in South India. ( 29495943 )
2018
7
Report of Relapse Typhoid Fever Cases from Kolkata, India: Recrudescence or Reinfection? ( 29709977 )
2018
8
Open label comparative trial of mono versus dual antibiotic therapy for Typhoid Fever in adults. ( 29684022 )
2018
9
Changing trends of culture-positive typhoid fever and antimicrobial susceptibility in a tertiary care North Indian Hospital over the last decade. ( 29735830 )
2018
10
Vaccines for preventing typhoid fever. ( 29851031 )
2018
11
Notes from the Field: Typhoid Fever Outbreak - Harare, Zimbabwe, October 2016-March 2017. ( 29565843 )
2018
12
Comparison of Strategies and Incidence Thresholds for Vi Conjugate Vaccines Against Typhoid Fever: A Cost-effectiveness Modeling Study. ( 29444257 )
2018
13
Development of a bivalent conjugate vaccine candidate against malaria transmission and typhoid fever. ( 29681410 )
2018
14
Epidemiology and risk factors for typhoid fever in Central Division, Fiji, 2014-2017: A case-control study. ( 29883448 )
2018
15
Typhoid Fever due to Extended Spectrum <i>I^</i>-Lactamase-Producing <i>Salmonella enterica</i> Serovar Typhi: A Case Report and Literature Review. ( 29666727 )
2018
16
A Traveler's Disease Without Leaving Home: Typhoid Fever. ( 29410237 )
2018
17
Assessment of water, sanitation and hygiene interventions in response to an outbreak of typhoid fever in Neno District, Malawi. ( 29474394 )
2018
18
Activation of coagulation and endothelium with concurrent impairment of anticoagulant mechanisms in patients with typhoid fever. ( 29746945 )
2018
19
Oral immunization with a novel attenuated Salmonella Gallinarum encoding infectious bronchitis virus spike protein induces protective immune responses against fowl typhoid and infectious bronchitis in chickens. ( 30208963 )
2018
20
Community-based prevalence of typhoid fever, typhus, brucellosis and malaria among symptomatic individuals in Afar Region, Ethiopia. ( 30286076 )
2018
21
Typhoid fever complicated by cholecystitis in a 10-year-old boy. ( 30474320 )
2018
22
Determinants of postoperative morbidity and mortality in children managed for typhoid intestinal perforation in Kano Nigeria. ( 29277466 )
2018
23
Dry Gangrene in Children with Typhoid Intestinal Perforation: A Report of Two Cases. ( 30402323 )
2018
24
Hematological abnormalities in patients with malaria and typhoid in Tamale Metropolis of Ghana. ( 29871667 )
2018
25
Typhoid and paratyphoid fever: a call to action. ( 30138141 )
2018
26
The Relationship Between Blood Sample Volume and Diagnostic Sensitivity of Blood Culture for Typhoid and Paratyphoid Fever: A Systematic Review and Meta-Analysis. ( 30307563 )
2018
27
Case Report: Typhoid Fever and Spotted Fever Group Rickettsiosis Presenting Concomitantly in an Indian Immigrant. ( 30062981 )
2018
28
Plasma IgA responses against two Salmonella Typhi antigens identify patients with typhoid fever. ( 30020426 )
2018
29
'Frightening' typhoid fever outbreak spreads in Pakistan. ( 30026207 )
2018
30
Why Is Eradicating Typhoid Fever So Challenging: Implications for Vaccine and Therapeutic Design. ( 30042307 )
2018
31
The Burden of Typhoid Fever in South Africa: The Potential Impact of Selected Interventions. ( 30047360 )
2018
32
Typhoid Fever: Way Forward. ( 30047361 )
2018
33
Typhoid Fever: Tracking the Trend in Nigeria. ( 30047362 )
2018
34
Implementation of Interventions for the Control of Typhoid Fever in Low- and Middle-Income Countries. ( 30047365 )
2018
35
Longitudinal Typhoid Fever Trends in India from 2000 to 2015. ( 30047367 )
2018
36
The Control of Typhoid Fever in Vietnam. ( 30047368 )
2018
37
Introductory Article on Global Burden and Epidemiology of Typhoid Fever. ( 30047370 )
2018
38
Typhoid Fever in Chile 1969-2012: Analysis of an Epidemic and Its Control. ( 30047371 )
2018
39
Typhoid fever: issues in laboratory detection, treatment options & concerns in management in developing countries. ( 30057789 )
2018
40
Typhoid fever: clinical presentation and associated factors in febrile patients visiting Shashemene Referral Hospital, southern Ethiopia. ( 30134970 )
2018
41
Estimating Typhoid Fever Risk Associated with Lack of Access to Safe Water: A Systematic Literature Review. ( 30174699 )
2018
42
Typhoid fever with isolated left lateral rectus palsy. ( 30181402 )
2018
43
Typhoid fever in Santiago, Chile: Insights from a mathematical model utilizing venerable archived data from a successful disease control program. ( 30188904 )
2018
44
Typhoid fever outbreak with severe complications in Yucatan, Mexico. ( 30223978 )
2018
45
Use of whole genome sequencing to complement characterisation of a typhoid fever outbreak among a Marshallese community: Oklahoma, 2015. ( 30236166 )
2018
46
Association between floods and typhoid fever in Yongzhou, China: Effects and vulnerable groups. ( 30241731 )
2018
47
The epidemiology of typhoid fever in the Dhulikhel area, Nepal: A prospective cohort study. ( 30261024 )
2018
48
Typhoid fever outbreak in the Democratic Republic of Congo: Case control and ecological study. ( 30281598 )
2018
49
Case-Fatality Ratio of Blood Culture-Confirmed Typhoid Fever in Dhaka, Bangladesh. ( 30304448 )
2018
50
Travellers take heed: Outbreak of extensively drug resistant (XDR) typhoid fever in Pakistan and a warning from the US CDC. ( 30339826 )
2018

Variations for Typhoid Fever

Expression for Typhoid Fever

Search GEO for disease gene expression data for Typhoid Fever.

Pathways for Typhoid Fever

Pathways related to Typhoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CASP1 CRP IFNG IFNGR1 IL1B IL6
2
Show member pathways
13.69 CASP1 F2 IFNG IFNGR1 IL1B IL6
3
Show member pathways
13.53 F2 IFNG IFNGR1 IL1B IL6 LTA
4
Show member pathways
13.38 CASP1 IFNG IFNGR1 IL1B IL6 LTA
5
Show member pathways
13.21 IFNG IFNGR1 IL1B TLR4 TLR5 TNF
6
Show member pathways
13.03 CASP1 IFNG IFNGR1 IL1B IL6 TLR4
7
Show member pathways
12.91 IFNG IFNGR1 IL1B IL6 LTA TNF
8
Show member pathways
12.81 CASP1 IFNG IL1B IL6 TLR4 TNF
9
Show member pathways
12.75 IL1B IL6 LTA TLR4 TLR5 TNF
10
Show member pathways
12.72 IFNG IFNGR1 IL1B LTA TNF
11
Show member pathways
12.72 CASP1 IFNG IFNGR1 IL1B IL6 LTA
12
Show member pathways
12.67 CASP1 IL1B LTA TLR4 TLR5 TNF
13
Show member pathways
12.63 F2 IFNG IL1B IL6 TNF
14
Show member pathways
12.58 IFNG IFNGR1 IL1B IL6 TLR4 TLR5
15
Show member pathways
12.44 IFNG IL1B IL6 TNF
16 12.44 IL6 LTA TNF VAC14
17
Show member pathways
12.38 IFNG IFNGR1 IL1B IL6 TLR4 TNF
18
Show member pathways
12.36 CFTR IFNG IL1B IL6 TLR5 TNF
19
Show member pathways
12.31 IFNG IL1B IL6 LTA TNF
20
Show member pathways
12.31 IFNG IFNGR1 IL1B TLR4 TNF
21
Show member pathways
12.3 IL6 TLR4 TLR5 TNF
22
Show member pathways
12.28 CFTR IL1B IL6 TLR5 TNF
23
Show member pathways
12.25 CASP1 IL1B IL6 TNF
24 12.24 IFNG IFNGR1 IL1B IL6 TLR4 TNF
25
Show member pathways
12.2 ALB CRP F2 IFNG IL1B IL6
26
Show member pathways
12.19 CASP1 IFNG IFNGR1 IL1B TLR4 TNF
27 12.15 IFNG IFNGR1 IL6 TLR4 TLR5 TNF
28
Show member pathways
12.12 CASP1 IFNG IFNGR1 IL1B IL6
29 12.1 IFNG IFNGR1 IL1B TNF
30 12.09 IFNG IL1B IL6 TLR4 TNF
31 12.03 IL1B IL6 LTA TNF
32 11.99 IFNG IL6 TNF
33 11.98 IL1B IL6 TNF
34 11.98 IFNG IFNGR1 IL6 TLR4
35 11.95 IL1B LTA TLR4 TNF
36 11.95 IFNG IL1B IL6 TLR4 TNF
37
Show member pathways
11.95 F2 IFNG IL1B IL6 TLR4 TNF
38 11.94 IFNG IL1B IL6
39 11.91 IL1B IL6 TNF
40 11.9 IL1B IL6 TNF
41 11.89 IFNG IL1B IL6 TLR4 TNF
42
Show member pathways
11.88 CFTR IL6 TLR4
43 11.87 IFNG IL1B LTA TNF
44 11.82 IFNG IL1B IL6 TNF
45 11.8 IFNG IL1B IL6 TNF
46 11.8 CASP1 IL1B IL6 TLR4 TNF
47
Show member pathways
11.78 CFTR IFNG IFNGR1 IL1B IL6 TLR4
48
Show member pathways
11.74 IFNG IL1B IL6 TNF
49 11.7 IL1B IL6 TNF
50 11.63 LTA TLR4 TNF

GO Terms for Typhoid Fever

Cellular components related to Typhoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 ALB CRP F2 IFNG IL1B IL6
2 endosome membrane GO:0010008 9.26 CFTR SLC11A1 TLR4 VAC14
3 extracellular space GO:0005615 9.23 ALB CRP F2 IFNG IL1B IL6

Biological processes related to Typhoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 SLC11A1 TLR4 TLR5 TNF
2 positive regulation of gene expression GO:0010628 9.98 CRP IFNG IL1B IL6 SLC11A1 TLR4
3 positive regulation of protein phosphorylation GO:0001934 9.95 F2 IFNG IL1B TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 CASP1 IL1B TLR4 TNF
5 response to lipopolysaccharide GO:0032496 9.94 IL1B LTA SLC11A1 TLR4
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL1B IL6 TLR4 TNF
7 inflammatory response GO:0006954 9.91 CRP IL1B IL6 SLC11A1 TLR4 TLR5
8 activation of MAPK activity GO:0000187 9.89 IL1B TLR4 TNF
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.89 IL1B IL6 TNF
10 response to virus GO:0009615 9.89 IFNG IFNGR1 TNF
11 defense response to Gram-positive bacterium GO:0050830 9.88 CRP IL6 LTA TNF
12 defense response to Gram-negative bacterium GO:0050829 9.87 IL6 SLC11A1 TLR4
13 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR4 TNF
14 regulation of insulin secretion GO:0050796 9.85 IFNG IL1B TNF
15 response to glucocorticoid GO:0051384 9.85 IL1B IL6 TNF
16 apoptotic signaling pathway GO:0097190 9.85 CASP1 TLR4 TNF
17 cellular response to mechanical stimulus GO:0071260 9.85 CASP1 IL1B TLR4 TLR5
18 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.84 IL1B TLR4 TNF
19 positive regulation of interleukin-6 production GO:0032755 9.83 IL1B IL6 TLR4 TNF
20 humoral immune response GO:0006959 9.81 IFNG IL6 LTA TNF
21 positive regulation of phagocytosis GO:0050766 9.8 IL1B SLC11A1 TNF
22 acute-phase response GO:0006953 9.79 CRP F2 IL6
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.79 IL1B TLR4 TNF
24 negative regulation of neurogenesis GO:0050768 9.76 IL1B IL6 TNF
25 positive regulation of chemokine production GO:0032722 9.74 IL6 TLR4 TNF
26 cellular response to lipopolysaccharide GO:0071222 9.73 CASP1 IL1B IL6 TLR4 TLR5 TNF
27 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
28 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
29 negative regulation of growth of symbiont in host GO:0044130 9.71 LTA TNF
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IFNG IL1B TNF
32 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TLR4 TLR5 TNF
33 regulation of cytokine secretion GO:0050707 9.7 TLR4 TLR5
34 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.7 IFNG IFNGR1
35 negative regulation of interleukin-17 production GO:0032700 9.7 IFNG TLR4
36 macrophage activation GO:0042116 9.7 SLC11A1 TLR4
37 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
38 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
39 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
40 negative regulation of lipid storage GO:0010888 9.67 CRP IL6 TNF
41 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
42 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.65 LTA TNF
43 chronic inflammatory response to antigenic stimulus GO:0002439 9.64 IL1B TNF
44 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
45 positive regulation of neuroinflammatory response GO:0150078 9.63 IL1B IL6 TNF
46 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.6 LTA TNF
47 positive regulation of vitamin D biosynthetic process GO:0060557 9.59 IFNG TNF
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.5 IFNG IL1B TNF
49 positive regulation of glial cell proliferation GO:0060252 9.46 IL1B IL6 LTA TNF
50 positive regulation of interferon-gamma production GO:0032729 9.35 IL1B LTA SLC11A1 TLR4 TNF

Molecular functions related to Typhoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL1B IL6 LTA TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR5

Sources for Typhoid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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