MCID: ULC005
MIFTS: 23

Ulcer of Lower Limbs

Categories: Skin diseases

Aliases & Classifications for Ulcer of Lower Limbs

MalaCards integrated aliases for Ulcer of Lower Limbs:

Name: Ulcer of Lower Limbs 12 15 37
Ulcer of Heel and Midfoot 12
Ulcer of Lower Limb 17
Ulcer of Ankle 12
Ulcer of Thigh 12
Ulcer of Calf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8529
ICD10 32 L97

Summaries for Ulcer of Lower Limbs

Disease Ontology : 12 Ulcer of lower limbs is a chronic ulcer of skin where the ulcer is not a decubitus ulcer.

MalaCards based summary : Ulcer of Lower Limbs, also known as ulcer of heel and midfoot, is related to spastic diplegia and radiculopathy. An important gene associated with Ulcer of Lower Limbs is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways is ATF-2 transcription factor network. Affiliated tissues include skin and t cells, and related phenotype is hematopoietic system.

Related Diseases for Ulcer of Lower Limbs

Graphical network of the top 20 diseases related to Ulcer of Lower Limbs:



Diseases related to Ulcer of Lower Limbs

Symptoms & Phenotypes for Ulcer of Lower Limbs

MGI Mouse Phenotypes related to Ulcer of Lower Limbs:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.23 ARG1 CAPNS1 CCL5 DPP4 EEF1A2 F9

Drugs & Therapeutics for Ulcer of Lower Limbs

Search Clinical Trials , NIH Clinical Center for Ulcer of Lower Limbs

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ulcer of Lower Limbs cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ulcer of Lower Limbs:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Ulcer of Lower Limbs:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Ulcer of Lower Limbs

Anatomical Context for Ulcer of Lower Limbs

MalaCards organs/tissues related to Ulcer of Lower Limbs:

40
Skin, T Cells

Publications for Ulcer of Lower Limbs

Articles related to Ulcer of Lower Limbs:

# Title Authors PMID Year
1
The Treatment of Low Leg Nonischemic Ulcers With a Traditional Chinese-Pharmaceutical Medium: A Randomized Controlled Multicenter Clinical Study. 61
31111752 2019
2
The association between participation in a pay-for-performance program and macrovascular complications in patients with type 2 diabetes in Taiwan: A nationwide population-based cohort study. 61
26740347 2016
3
Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease. 61
23773718 2013
4
[Clinical study of syndrome differentiation standards for chronic skin ulcer of lower limbs]. 61
20015434 2009
5
[Biological characteristics of microorganisms for prognosis of trophic ulcers course]. 61
19718833 2009
6
[The value of regulated upon activation normal T cell expressed and secreted in the pathogenesis of varicose ulcer of lower limbs]. 61
19953896 2009
7
[Clinical efficacy of using ximedon in surgical practice]. 61
12733496 2002

Variations for Ulcer of Lower Limbs

Expression for Ulcer of Lower Limbs

Search GEO for disease gene expression data for Ulcer of Lower Limbs.

Pathways for Ulcer of Lower Limbs

Pathways related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.36 INS ARG1

GO Terms for Ulcer of Lower Limbs

Molecular functions related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 TNFRSF10A INS DPP4 CCL5 ARG1
2 protease binding GO:0002020 8.8 TNFRSF10A INS DPP4

Sources for Ulcer of Lower Limbs

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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