MCID: ULC005
MIFTS: 35

Ulcer of Lower Limbs

Categories: Skin diseases

Aliases & Classifications for Ulcer of Lower Limbs

MalaCards integrated aliases for Ulcer of Lower Limbs:

Name: Ulcer of Lower Limbs 12 15 37
Ulcer of Heel and Midfoot 12
Ulcer of Lower Limb 17
Ulcer of Ankle 12
Ulcer of Thigh 12
Ulcer of Calf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8529
ICD10 32 L97

Summaries for Ulcer of Lower Limbs

Disease Ontology : 12 Ulcer of lower limbs is a chronic ulcer of skin where the ulcer is not a decubitus ulcer.

MalaCards based summary : Ulcer of Lower Limbs, also known as ulcer of heel and midfoot, is related to obesity-hypoventilation syndrome and gastrointestinal ulceration, recurrent, with dysfunctional platelets. An important gene associated with Ulcer of Lower Limbs is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. Affiliated tissues include skin, and related phenotypes are hematopoietic system and cardiovascular system

Related Diseases for Ulcer of Lower Limbs

Diseases related to Ulcer of Lower Limbs via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 483)
# Related Disease Score Top Affiliating Genes
1 obesity-hypoventilation syndrome 10.3 IL6 CCL5
2 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.3
3 adhesive otitis media 10.2 FGF2 F9
4 meningococcemia 10.2 IL1B CCL5
5 osteosclerotic myeloma 10.2 VEGFA IL6
6 gorham's disease 10.2 VEGFA IL6
7 prosthetic joint infection 10.2 IL6 IL1B
8 periodontitis, chronic 10.2 IL6 IL1B
9 juvenile nasopharyngeal angiofibroma 10.1 VEGFA FGF2
10 uremic pruritus 10.1 IL6 IL1B
11 indolent plasma cell myeloma 10.1 IL6 IL1B
12 suppurative periapical periodontitis 10.1 IL6 IL1B
13 vulvovaginitis 10.1 DPP4 CCL5
14 hypoglycemic coma 10.1 VEGFA DPP4
15 traumatic brain injury 10.1 IL6 IL1B
16 brain injury 10.1 IL6 IL1B
17 idiopathic hypercalciuria 10.1 IL1B FGF2
18 recurrent corneal erosion 10.1 IL6 IL1B
19 near-fatal asthma 10.1 TNF CCL5
20 pseudopterygium 10.1 TNFRSF10A FGF2
21 angiodysplasia 10.1 VEGFA FGF2
22 spotted fever rickettsiosis 10.1 TNF CCL5
23 capillary disease 10.1 VEGFA IL6 FGF2
24 intussusception 10.1 VEGFA IL6 FGF2
25 anaerobic pneumonia 10.0 IL6 IL1B CCL5
26 pericardial effusion 10.0 VEGFA IL6 FGF2
27 diabetic macular edema 10.0 VEGFA IL6 FGF2
28 external pathological resorption 10.0 TNF IL6
29 human cytomegalovirus infection 10.0 IL6 IL1B CCL5
30 placental insufficiency 10.0 VEGFA IL6 FGF2
31 enterocolitis 10.0 TNF IL6
32 breast carcinoma in situ 10.0 VEGFA IL6 FGF2
33 peripheral vascular disease 10.0
34 chronic venous insufficiency 10.0
35 venous insufficiency 10.0
36 orofacial granulomatosis 10.0 TNF CCL5
37 retinal artery occlusion 10.0 VEGFA IL6 F9
38 extrinsic allergic alveolitis 10.0 IL6 IL1B CCL5
39 yellow fever 10.0 IL6 IL1B CCL5
40 idiopathic anterior uveitis 10.0 TNF IL6
41 gastroesophageal junction adenocarcinoma 10.0 VEGFA IL1B
42 streptococcal toxic-shock syndrome 10.0 TNF IL6
43 angioimmunoblastic lymphadenopathy with dysproteinemia 10.0 TNF IL6
44 colorectal adenoma 10.0 VEGFA IL6 GREM1
45 cardiogenic shock 10.0 TNF IL6
46 corneal neovascularization 10.0 VEGFA IL1B FGF2
47 null-cell leukemia 10.0 TNF IL6
48 systemic onset juvenile idiopathic arthritis 10.0 TNF IL6
49 glomeruloid hemangioma 10.0 VEGFA IL6 IL1B
50 posterior urethral valves 10.0 TNF IL6

Graphical network of the top 20 diseases related to Ulcer of Lower Limbs:



Diseases related to Ulcer of Lower Limbs

Symptoms & Phenotypes for Ulcer of Lower Limbs

MGI Mouse Phenotypes related to Ulcer of Lower Limbs:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CAPNS1 CCL5 DPP4 F9 FGF2 IL1B
2 cardiovascular system MP:0005385 10.03 CAPNS1 DPP4 F9 FGF2 IL1B IL6
3 homeostasis/metabolism MP:0005376 10.02 CAPNS1 DPP4 F9 FGF2 GREM1 IL1B
4 cellular MP:0005384 10.01 CAPNS1 DPP4 FGF2 GREM1 IL6 TNF
5 immune system MP:0005387 9.86 CCL5 DPP4 F9 IL1B IL6 TNF
6 mortality/aging MP:0010768 9.85 CAPNS1 DPP4 F9 FGF2 GREM1 IL1B
7 neoplasm MP:0002006 9.43 FGF2 IL1B IL6 TNF TNFRSF10A VEGFA
8 respiratory system MP:0005388 9.1 CAPNS1 DPP4 GREM1 IL6 TNF VEGFA

Drugs & Therapeutics for Ulcer of Lower Limbs

Search Clinical Trials , NIH Clinical Center for Ulcer of Lower Limbs

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ulcer of Lower Limbs cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ulcer of Lower Limbs:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Ulcer of Lower Limbs:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Ulcer of Lower Limbs

Anatomical Context for Ulcer of Lower Limbs

MalaCards organs/tissues related to Ulcer of Lower Limbs:

40
Skin

Publications for Ulcer of Lower Limbs

Articles related to Ulcer of Lower Limbs:

# Title Authors PMID Year
1
[Clinical efficacy and influencing factors of different modes of continuous negative pressure wound therapy on venous ulcer wounds of lower limbs]. 61
33379851 2020
2
The Treatment of Low Leg Nonischemic Ulcers With a Traditional Chinese-Pharmaceutical Medium: A Randomized Controlled Multicenter Clinical Study. 61
31111752 2019
3
The association between participation in a pay-for-performance program and macrovascular complications in patients with type 2 diabetes in Taiwan: A nationwide population-based cohort study. 61
26740347 2016
4
Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease. 61
23773718 2013
5
[Clinical study of syndrome differentiation standards for chronic skin ulcer of lower limbs]. 61
20015434 2009
6
[Biological characteristics of microorganisms for prognosis of trophic ulcers course]. 61
19718833 2009
7
[The value of regulated upon activation normal T cell expressed and secreted in the pathogenesis of varicose ulcer of lower limbs]. 61
19953896 2009
8
[Clinical efficacy of using ximedon in surgical practice]. 61
12733496 2002

Variations for Ulcer of Lower Limbs

Expression for Ulcer of Lower Limbs

Search GEO for disease gene expression data for Ulcer of Lower Limbs.

Pathways for Ulcer of Lower Limbs

Pathways related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 VEGFA TNFRSF10A TNF IL6 IL1B FGF2
2
Show member pathways
13.4 VEGFA TNFRSF10A TNF IL6 IL1B FGF2
3
Show member pathways
13.28 TNFRSF10A TNF IL6 IL1B FGF2 CCL5
4
Show member pathways
13.24 VEGFA TNF IL6 IL1B FGF2 CCL5
5
Show member pathways
13.18 TNFRSF10A TNF IL6 IL1B FGF2 CCL5
6
Show member pathways
13.09 TNFRSF10A TNF IL6 IL1B CCL5
7
Show member pathways
12.96 VEGFA TNFRSF10A TNF IL6 CCL5
8
Show member pathways
12.76 VEGFA TNF IL6 IL1B
9
Show member pathways
12.74 TNF IL6 IL1B CCL5
10 12.71 TNF IL6 IL1B CCL5
11
Show member pathways
12.7 TNFRSF10A TNF IL6 IL1B CCL5
12
Show member pathways
12.68 VEGFA TNF IL6 IL1B FGF2 CCL5
13 12.67 VEGFA TNF IL1B FGF2
14
Show member pathways
12.65 TNFRSF10A TNF IL6 IL1B
15
Show member pathways
12.6 TNF IL6 IL1B FGF2
16
Show member pathways
12.5 TNF IL6 IL1B FGF2
17 12.32 TNF IL1B CCL5 CAPNS1
18
Show member pathways
12.24 TNF IL6 IL1B FGF2
19
Show member pathways
12.24 TNFRSF10A TNF IL6 CCL5
20
Show member pathways
12.23 TNF IL6 IL1B CCL5
21
Show member pathways
12.18 TNF IL6 IL1B FGF2
22
Show member pathways
12.14 TNF IL6 IL1B
23
Show member pathways
12.13 TNFRSF10A TNF IL1B
24 12.12 TNF IL6 IL1B CCL5
25 12.11 VEGFA TNF IL6
26
Show member pathways
12.11 TNF IL6 IL1B
27 12.03 VEGFA TNF IL6 IL1B
28 12.01 VEGFA TNF IL1B
29 12.01 TNF IL6 IL1B
30 11.99 VEGFA IL6 FGF2
31 11.93 TNF IL6 IL1B
32 11.86 TNF IL6 IL1B
33 11.84 TNF IL6 IL1B
34 11.78 TNF IL6 IL1B CCL5
35
Show member pathways
11.71 TNF IL6 IL1B
36 11.7 TNF IL6 IL1B
37 11.69 TNF IL6 IL1B
38 11.67 VEGFA TNF IL6 IL1B
39 11.61 VEGFA TNF IL6 IL1B FGF2
40 11.54 TNF IL6 IL1B
41 11.46 TNF IL6 IL1B
42 11.43 VEGFA IL6 FGF2
43
Show member pathways
11.42 VEGFA TNF IL6 IL1B
44 11.4 TNF IL6 IL1B
45 11.32 VEGFA TNF IL6 IL1B CCL5
46 11.28 TNF IL6 IL1B
47 11.25 TNF IL6 IL1B CCL5
48 11.23 TNF IL6 IL1B
49 11.18 TNF IL6 IL1B
50 11.14 TNF IL6 IL1B

GO Terms for Ulcer of Lower Limbs

Cellular components related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 VEGFA TNF IL6 IL1B GREM1 FGF2
2 cell surface GO:0009986 9.55 VEGFA TNFRSF10A TNF GREM1 DPP4
3 extracellular region GO:0005576 9.28 VEGFA TNF IL6 IL1B GREM1 FGF2

Biological processes related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.21 VEGFA TNFRSF10A IL6 IL1B GREM1 FGF2
2 positive regulation of transcription, DNA-templated GO:0045893 10.07 TNF IL6 IL1B GREM1 FGF2
3 immune response GO:0006955 10.01 TNF IL6 IL1B CCL5
4 inflammatory response GO:0006954 9.99 TNF IL6 IL1B CCL5
5 positive regulation of gene expression GO:0010628 9.98 VEGFA TNF IL6 IL1B FGF2
6 MAPK cascade GO:0000165 9.96 TNF IL1B FGF2 CCL5
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 VEGFA TNF FGF2 CCL5
8 cellular response to lipopolysaccharide GO:0071222 9.89 TNF IL6 IL1B
9 positive regulation of protein phosphorylation GO:0001934 9.89 VEGFA TNF IL1B FGF2
10 animal organ morphogenesis GO:0009887 9.88 TNF GREM1 FGF2
11 activation of MAPK activity GO:0000187 9.87 TNF IL1B FGF2
12 positive regulation of MAPK cascade GO:0043410 9.86 VEGFA IL6 FGF2
13 positive regulation of DNA-binding transcription factor activity GO:0051091 9.86 TNF IL6 IL1B
14 positive regulation of interleukin-6 production GO:0032755 9.85 TNF IL6 IL1B
15 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.84 VEGFA TNF IL6
16 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 TNF IL6 IL1B GREM1
17 cellular response to organic cyclic compound GO:0071407 9.83 TNF IL1B CCL5
18 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TNF IL1B GREM1
19 positive regulation of angiogenesis GO:0045766 9.83 VEGFA IL1B GREM1 FGF2
20 positive regulation of T cell proliferation GO:0042102 9.82 IL6 IL1B CCL5
21 positive regulation of smooth muscle cell proliferation GO:0048661 9.82 TNF IL6 CCL5
22 positive regulation of MAP kinase activity GO:0043406 9.8 VEGFA TNF FGF2
23 positive regulation of interleukin-8 production GO:0032757 9.8 TNF IL6 IL1B
24 positive regulation of cell adhesion GO:0045785 9.79 VEGFA TNF CCL5
25 positive regulation of cell division GO:0051781 9.75 VEGFA IL1B FGF2
26 positive chemotaxis GO:0050918 9.74 VEGFA FGF2 CCL5
27 protein kinase B signaling GO:0043491 9.72 TNF IL1B CCL5
28 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.71 VEGFA GREM1
29 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.71 VEGFA TNF FGF2 CCL5
30 negative regulation of lipid catabolic process GO:0050995 9.7 TNF IL1B
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 TNF IL1B
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 TNF IL1B
33 positive regulation of DNA biosynthetic process GO:2000573 9.69 VEGFA FGF2
34 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.69 TNF IL6
35 positive regulation of JAK-STAT cascade GO:0046427 9.69 TNF IL6 CCL5
36 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
37 negative regulation of lipid storage GO:0010888 9.67 TNF IL6
38 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF IL1B CCL5
39 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 VEGFA TNF IL6 CCL5
40 negative regulation of neurogenesis GO:0050768 9.65 TNF IL6 IL1B
41 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.64 VEGFA GREM1
42 positive regulation of fever generation GO:0031622 9.63 TNF IL1B
43 cell migration involved in sprouting angiogenesis GO:0002042 9.63 VEGFA GREM1 FGF2
44 cytokine-mediated signaling pathway GO:0019221 9.63 VEGFA TNF IL6 IL1B FGF2 CCL5
45 positive regulation of epithelial tube formation GO:1905278 9.61 VEGFA FGF2
46 positive regulation of glial cell proliferation GO:0060252 9.61 TNF IL6 IL1B
47 sequestering of triglyceride GO:0030730 9.6 TNF IL1B
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 TNF IL1B
49 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
50 positive regulation of cell proliferation GO:0008284 9.5 VEGFA IL6 IL1B GREM1 FGF2 DPP4

Molecular functions related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 VEGFA TNFRSF10A TNF FGF2 DPP4 CCL5
2 growth factor activity GO:0008083 9.54 VEGFA IL6 FGF2
3 protease binding GO:0002020 9.43 TNFRSF10A TNF DPP4
4 cytokine activity GO:0005125 9.17 VEGFA TNF IL6 IL1B GREM1 FGF2
5 vascular endothelial growth factor receptor 2 binding GO:0043184 9.16 VEGFA GREM1
6 chemoattractant activity GO:0042056 9.13 VEGFA FGF2 CCL5

Sources for Ulcer of Lower Limbs

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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