Ulcer of Lower Limbs disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ulcer of Lower Limbs

MalaCards integrated aliases for Ulcer of Lower Limbs:

Name: Ulcer of Lower Limbs ¹² ¹⁵ ³⁷

Ulcer of Heel and Midfoot ¹²

Ulcer of Lower Limb ¹⁷

Ulcer of Ankle ¹²

Ulcer of Thigh ¹²

Ulcer of Calf ¹²

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the skin and subcutaneous tissue

Other disorders of the skin and subcutaneous tissue

Ulcer of lower limb, not elsewhere classified

External Ids:

Disease Ontology ¹² DOID:8529

ICD10 ³² L97

EFO ¹⁷ EFO_0007068

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Summaries for Ulcer of Lower Limbs

Disease Ontology : ¹² Ulcer of lower limbs is a chronic ulcer of skin where the ulcer is not a decubitus ulcer.

MalaCards based summary : Ulcer of Lower Limbs, also known as ulcer of heel and midfoot, is related to spastic diplegia and radiculopathy. An important gene associated with Ulcer of Lower Limbs is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways is ATF-2 transcription factor network. Affiliated tissues include skin and t cells, and related phenotype is hematopoietic system.

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Related Diseases for Ulcer of Lower Limbs

Diseases related to Ulcer of Lower Limbs via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)

#	Related Disease	Score	Top Affiliating Genes
1	spastic diplegia	10.1	HECTD4 ARG1
2	radiculopathy	10.1	HECTD4 CCL5
3	neurogenic arthropathy	10.1	INS HECTD4
4	asphyxia neonatorum	10.1	INS HECTD4
5	venous insufficiency	10.1
6	nerve compression syndrome	10.1	INS HECTD4
7	decubitus ulcer	10.1	INS HECTD4
8	chronic ulcer of skin	10.0	INS HECTD4
9	q fever	9.9	CCL5 ARG1
10	hirata disease	9.9	TNFRSF10A INS
11	type 1 diabetes mellitus 12	9.9	TNFRSF10A INS
12	barre-lieou syndrome	9.9	HECTD4 DPP4
13	type 1 diabetes mellitus 2	9.9	TNFRSF10A INS
14	gastrointestinal ulceration, recurrent, with dysfunctional platelets	9.9
15	peripheral vascular disease	9.9
16	chronic venous insufficiency	9.9
17	adult syndrome	9.9	WDR20 INS
18	adrenal cortical hypofunction	9.8	TNFRSF10A INS
19	splenic flexure cancer	9.7	INS DPP4
20	hypoglycemic coma	9.7	INS DPP4
21	nasopharyngitis	9.7	INS DPP4
22	maturity-onset diabetes of the young, type 1	9.6	INS DPP4
23	diabetes mellitus, ketosis-prone	9.6	INS DPP4
24	autoimmune disease of endocrine system	9.5	TNFRSF10A INS
25	intermediate coronary syndrome	9.4	INS EEF1A2 DPP4
26	peripheral nervous system disease	9.3	INS HECTD4 DPP4
27	prediabetes syndrome	9.2	INS DPP4
28	celiac disease 1	9.2	TNFRSF10A INS DPP4
29	myocardial infarction	8.9	INS F9 DPP4 CCL5 ARG1
30	hypertension, essential	8.7	INS EEF1A2 DPP4 CCL5 ARG1

Graphical network of the top 20 diseases related to Ulcer of Lower Limbs:

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Symptoms & Phenotypes for Ulcer of Lower Limbs

MGI Mouse Phenotypes related to Ulcer of Lower Limbs:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.23	ARG1 CAPNS1 CCL5 DPP4 EEF1A2 F9

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Drugs & Therapeutics for Ulcer of Lower Limbs

Search Clinical Trials , NIH Clinical Center for Ulcer of Lower Limbs

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Ulcer of Lower Limbs cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Ulcer of Lower Limbs:

Peripheral blood-derived hematopoietic stem cells for leg gangrene

Embryonic/Adult Cultured Cells Related to Ulcer of Lower Limbs:

Peripheral blood-derived hematopoietic stem cells

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Genetic Tests for Ulcer of Lower Limbs

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Anatomical Context for Ulcer of Lower Limbs

MalaCards organs/tissues related to Ulcer of Lower Limbs:

⁴⁰

Skin, T Cells

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Publications for Ulcer of Lower Limbs

Articles related to Ulcer of Lower Limbs:

#	Title	Authors	PMID	Year
1	The Treatment of Low Leg Nonischemic Ulcers With a Traditional Chinese-Pharmaceutical Medium: A Randomized Controlled Multicenter Clinical Study. ⁶¹	Zhang J...Yao C	31111752	2019
2	The association between participation in a pay-for-performance program and macrovascular complications in patients with type 2 diabetes in Taiwan: A nationwide population-based cohort study. ⁶¹	Hsieh HM...Chiu HC	26740347	2016
3	Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease. ⁶¹	Marino G...Barbarisi A	23773718	2013
4	[Clinical study of syndrome differentiation standards for chronic skin ulcer of lower limbs]. ⁶¹	Wang YJ...Que HF	20015434	2009
5	[Biological characteristics of microorganisms for prognosis of trophic ulcers course]. ⁶¹	Kartashova OL...Kirgizova SB	19718833	2009
6	[The value of regulated upon activation normal T cell expressed and secreted in the pathogenesis of varicose ulcer of lower limbs]. ⁶¹	Chen LH...Wang SM	19953896	2009
7	[Clinical efficacy of using ximedon in surgical practice]. ⁶¹	Izmailov SG...Gerasimova MKh	12733496	2002

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Genes for Ulcer of Lower Limbs

Genes related to Ulcer of Lower Limbs (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	9.79	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	ZSCAN32	Zinc Finger And SCAN Domain Containing 32	Protein Coding	6.77	DISEASES inferred ¹⁵
3	HECTD4	HECT Domain E3 Ubiquitin Protein Ligase 4	Protein Coding	5.6	DISEASES inferred ¹⁵
4	CAPNS1	Calpain Small Subunit 1	Protein Coding	4.74	DISEASES inferred ¹⁵
5	SAGE1	Sarcoma Antigen 1	Protein Coding	4.65	DISEASES inferred ¹⁵
6	WDR20	WD Repeat Domain 20	Protein Coding	4.36	DISEASES inferred ¹⁵
7	F9	Coagulation Factor IX	Protein Coding	4.17	DISEASES inferred ¹⁵
8	ARG1	Arginase 1	Protein Coding	3.72	DISEASES inferred ¹⁵
9	EEF1A2	Eukaryotic Translation Elongation Factor 1 Alpha 2	Protein Coding	3.72	DISEASES inferred ¹⁵
10	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	3.67	DISEASES inferred ¹⁵
11	DPP4	Dipeptidyl Peptidase 4	Protein Coding	3.39	DISEASES inferred ¹⁵
12	INS	Insulin	Protein Coding	3.32	DISEASES inferred ¹⁵

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Variations for Ulcer of Lower Limbs

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Expression for Ulcer of Lower Limbs

Search GEO for disease gene expression data for Ulcer of Lower Limbs.

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Pathways for Ulcer of Lower Limbs

Pathways related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	ATF-2 transcription factor network ¹	10.36	INS ARG1

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GO Terms for Ulcer of Lower Limbs

Molecular functions related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.35	TNFRSF10A INS DPP4 CCL5 ARG1
2	protease binding	GO:0002020	8.8	TNFRSF10A INS DPP4

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Sources for Ulcer of Lower Limbs

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia