Ulcer of Lower Limbs disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ULC005 MIFTS: 35	Ulcer of Lower Limbs Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Ulcer of Lower Limbs

MalaCards integrated aliases for Ulcer of Lower Limbs:

Name: Ulcer of Lower Limbs ¹² ¹⁵ ³⁷

Ulcer of Heel and Midfoot ¹²

Ulcer of Lower Limb ¹⁷

Ulcer of Ankle ¹²

Ulcer of Thigh ¹²

Ulcer of Calf ¹²

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the skin and subcutaneous tissue

Other disorders of the skin and subcutaneous tissue

Ulcer of lower limb, not elsewhere classified

External Ids:

Disease Ontology ¹² DOID:8529

ICD10 ³² L97

EFO ¹⁷ EFO_0007068

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Summaries for Ulcer of Lower Limbs

Disease Ontology : ¹² Ulcer of lower limbs is a chronic ulcer of skin where the ulcer is not a decubitus ulcer.

MalaCards based summary : Ulcer of Lower Limbs, also known as ulcer of heel and midfoot, is related to obesity-hypoventilation syndrome and gastrointestinal ulceration, recurrent, with dysfunctional platelets. An important gene associated with Ulcer of Lower Limbs is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. Affiliated tissues include skin, and related phenotypes are hematopoietic system and cardiovascular system

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Related Diseases for Ulcer of Lower Limbs

Diseases related to Ulcer of Lower Limbs via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 483)

#	Related Disease	Score	Top Affiliating Genes
1	obesity-hypoventilation syndrome	10.3	IL6 CCL5
2	gastrointestinal ulceration, recurrent, with dysfunctional platelets	10.3
3	adhesive otitis media	10.2	FGF2 F9
4	meningococcemia	10.2	IL1B CCL5
5	osteosclerotic myeloma	10.2	VEGFA IL6
6	gorham's disease	10.2	VEGFA IL6
7	prosthetic joint infection	10.2	IL6 IL1B
8	periodontitis, chronic	10.2	IL6 IL1B
9	juvenile nasopharyngeal angiofibroma	10.1	VEGFA FGF2
10	uremic pruritus	10.1	IL6 IL1B
11	indolent plasma cell myeloma	10.1	IL6 IL1B
12	suppurative periapical periodontitis	10.1	IL6 IL1B
13	vulvovaginitis	10.1	DPP4 CCL5
14	hypoglycemic coma	10.1	VEGFA DPP4
15	traumatic brain injury	10.1	IL6 IL1B
16	brain injury	10.1	IL6 IL1B
17	idiopathic hypercalciuria	10.1	IL1B FGF2
18	recurrent corneal erosion	10.1	IL6 IL1B
19	near-fatal asthma	10.1	TNF CCL5
20	pseudopterygium	10.1	TNFRSF10A FGF2
21	angiodysplasia	10.1	VEGFA FGF2
22	spotted fever rickettsiosis	10.1	TNF CCL5
23	capillary disease	10.1	VEGFA IL6 FGF2
24	intussusception	10.1	VEGFA IL6 FGF2
25	anaerobic pneumonia	10.0	IL6 IL1B CCL5
26	pericardial effusion	10.0	VEGFA IL6 FGF2
27	diabetic macular edema	10.0	VEGFA IL6 FGF2
28	external pathological resorption	10.0	TNF IL6
29	human cytomegalovirus infection	10.0	IL6 IL1B CCL5
30	placental insufficiency	10.0	VEGFA IL6 FGF2
31	enterocolitis	10.0	TNF IL6
32	breast carcinoma in situ	10.0	VEGFA IL6 FGF2
33	peripheral vascular disease	10.0
34	chronic venous insufficiency	10.0
35	venous insufficiency	10.0
36	orofacial granulomatosis	10.0	TNF CCL5
37	retinal artery occlusion	10.0	VEGFA IL6 F9
38	extrinsic allergic alveolitis	10.0	IL6 IL1B CCL5
39	yellow fever	10.0	IL6 IL1B CCL5
40	idiopathic anterior uveitis	10.0	TNF IL6
41	gastroesophageal junction adenocarcinoma	10.0	VEGFA IL1B
42	streptococcal toxic-shock syndrome	10.0	TNF IL6
43	angioimmunoblastic lymphadenopathy with dysproteinemia	10.0	TNF IL6
44	colorectal adenoma	10.0	VEGFA IL6 GREM1
45	cardiogenic shock	10.0	TNF IL6
46	corneal neovascularization	10.0	VEGFA IL1B FGF2
47	null-cell leukemia	10.0	TNF IL6
48	systemic onset juvenile idiopathic arthritis	10.0	TNF IL6
49	glomeruloid hemangioma	10.0	VEGFA IL6 IL1B
50	posterior urethral valves	10.0	TNF IL6

Graphical network of the top 20 diseases related to Ulcer of Lower Limbs:

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Symptoms & Phenotypes for Ulcer of Lower Limbs

MGI Mouse Phenotypes related to Ulcer of Lower Limbs:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.07	CAPNS1 CCL5 DPP4 F9 FGF2 IL1B
2	cardiovascular system	MP:0005385	10.03	CAPNS1 DPP4 F9 FGF2 IL1B IL6
3	homeostasis/metabolism	MP:0005376	10.02	CAPNS1 DPP4 F9 FGF2 GREM1 IL1B
4	cellular	MP:0005384	10.01	CAPNS1 DPP4 FGF2 GREM1 IL6 TNF
5	immune system	MP:0005387	9.86	CCL5 DPP4 F9 IL1B IL6 TNF
6	mortality/aging	MP:0010768	9.85	CAPNS1 DPP4 F9 FGF2 GREM1 IL1B
7	neoplasm	MP:0002006	9.43	FGF2 IL1B IL6 TNF TNFRSF10A VEGFA
8	respiratory system	MP:0005388	9.1	CAPNS1 DPP4 GREM1 IL6 TNF VEGFA

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Drugs & Therapeutics for Ulcer of Lower Limbs

Search Clinical Trials , NIH Clinical Center for Ulcer of Lower Limbs

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Ulcer of Lower Limbs cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Ulcer of Lower Limbs:

Peripheral blood-derived hematopoietic stem cells for leg gangrene

Embryonic/Adult Cultured Cells Related to Ulcer of Lower Limbs:

Peripheral blood-derived hematopoietic stem cells

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Genetic Tests for Ulcer of Lower Limbs

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Anatomical Context for Ulcer of Lower Limbs

MalaCards organs/tissues related to Ulcer of Lower Limbs:

⁴⁰

Skin

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Publications for Ulcer of Lower Limbs

Articles related to Ulcer of Lower Limbs:

#	Title	Authors	PMID	Year
1	[Clinical efficacy and influencing factors of different modes of continuous negative pressure wound therapy on venous ulcer wounds of lower limbs]. ⁶¹	Yang ML...Li QF	33379851	2020
2	The Treatment of Low Leg Nonischemic Ulcers With a Traditional Chinese-Pharmaceutical Medium: A Randomized Controlled Multicenter Clinical Study. ⁶¹	Zhang J...Yao C	31111752	2019
3	The association between participation in a pay-for-performance program and macrovascular complications in patients with type 2 diabetes in Taiwan: A nationwide population-based cohort study. ⁶¹	Hsieh HM...Chiu HC	26740347	2016
4	Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease. ⁶¹	Marino G...Barbarisi A	23773718	2013
5	[Clinical study of syndrome differentiation standards for chronic skin ulcer of lower limbs]. ⁶¹	Wang YJ...Que HF	20015434	2009
6	[Biological characteristics of microorganisms for prognosis of trophic ulcers course]. ⁶¹	Kartashova OL...Kirgizova SB	19718833	2009
7	[The value of regulated upon activation normal T cell expressed and secreted in the pathogenesis of varicose ulcer of lower limbs]. ⁶¹	Chen LH...Wang SM	19953896	2009
8	[Clinical efficacy of using ximedon in surgical practice]. ⁶¹	Izmailov SG...Gerasimova MKh	12733496	2002

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Genes for Ulcer of Lower Limbs

Genes related to Ulcer of Lower Limbs (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	7.15	GeneCards inferred via : Publications (show sections)
2	CAPNS1	Calpain Small Subunit 1	Protein Coding	5.1	DISEASES inferred ¹⁵
3	FGF2	Fibroblast Growth Factor 2	Protein Coding	4.23	DISEASES inferred ¹⁵
4	GREM1	Gremlin 1, DAN Family BMP Antagonist	Protein Coding	4.14	DISEASES inferred ¹⁵
5	F9	Coagulation Factor IX	Protein Coding	4.02	DISEASES inferred ¹⁵
6	IL6	Interleukin 6	Protein Coding	3.68	DISEASES inferred ¹⁵
7	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	3.59	DISEASES inferred ¹⁵
8	IL1B	Interleukin 1 Beta	Protein Coding	3.59	DISEASES inferred ¹⁵
9	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	3.47	DISEASES inferred ¹⁵
10	TNF	Tumor Necrosis Factor	Protein Coding	3.36	DISEASES inferred ¹⁵
11	DPP4	Dipeptidyl Peptidase 4	Protein Coding	3.21	DISEASES inferred ¹⁵

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Variations for Ulcer of Lower Limbs

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Expression for Ulcer of Lower Limbs

Search GEO for disease gene expression data for Ulcer of Lower Limbs.

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Pathways for Ulcer of Lower Limbs

Pathways related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

(show top 50) (show all 60)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.62	VEGFA TNFRSF10A TNF IL6 IL1B FGF2
2	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.4	VEGFA TNFRSF10A TNF IL6 IL1B FGF2
3	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.28	TNFRSF10A TNF IL6 IL1B FGF2 CCL5
4	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.24	VEGFA TNF IL6 IL1B FGF2 CCL5
5	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.18	TNFRSF10A TNF IL6 IL1B FGF2 CCL5
6	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Lipid and atherosclerosis ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.09	TNFRSF10A TNF IL6 IL1B CCL5
7	TNFR1 Pathway ⁶³ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²³ Apoptosis through Death Receptors ⁶³ Apoptotic Pathways Triggered By HIV1 ⁶³ Death Receptor Signaling ⁶⁶ DR3 Signaling ⁶³ Fas Signaling ⁶³ GITR Pathway ⁶³ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁵ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶³ TNF Signaling ⁶⁶ TRAIL Pathway ⁶³ TWEAK Pathway ⁶³	12.96	VEGFA TNFRSF10A TNF IL6 CCL5
8	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.76	VEGFA TNF IL6 IL1B
9	Prion disease ³⁶ Show member pathways Parkinson disease ³⁶	12.74	TNF IL6 IL1B CCL5
10	Herpes simplex virus 1 infection ³⁶	12.71	TNF IL6 IL1B CCL5
11	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.7	TNFRSF10A TNF IL6 IL1B CCL5
12	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.68	VEGFA TNF IL6 IL1B FGF2 CCL5
13	MAPK signaling pathway ³⁶ ¹	12.67	VEGFA TNF IL1B FGF2
14	Salmonella infection (KEGG) ³⁶ Show member pathways Pathogenic Escherichia coli infection ³⁶	12.65	TNFRSF10A TNF IL6 IL1B
15	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.6	TNF IL6 IL1B FGF2
16	Immune response IL-23 signaling pathway ²³ Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²³ Development PDGF signaling via STATs and NF-kB ²³ IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²³ Rac1/Pak1/p38/MMP-2 pathway ¹	12.5	TNF IL6 IL1B FGF2
17	Shigellosis ³⁶	12.32	TNF IL1B CCL5 CAPNS1
18	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²³ iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.24	TNF IL6 IL1B FGF2
19	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.24	TNFRSF10A TNF IL6 CCL5
20	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.23	TNF IL6 IL1B CCL5
21	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.18	TNF IL6 IL1B FGF2
22	C-type lectin receptor signaling pathway ³⁶ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁴	12.14	TNF IL6 IL1B
23	Necroptosis ³⁶ Show member pathways Nanoparticle triggered regulated necrosis ¹	12.13	TNFRSF10A TNF IL1B
24	NOD-like receptor signaling pathway ³⁶	12.12	TNF IL6 IL1B CCL5
25	Colorectal Cancer Metastasis ⁶³	12.11	VEGFA TNF IL6
26	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	12.11	TNF IL6 IL1B
27	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.03	VEGFA TNF IL6 IL1B
28	Fluid shear stress and atherosclerosis ³⁶	12.01	VEGFA TNF IL1B
29	Yersinia infection ³⁶	12.01	TNF IL6 IL1B
30	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.99	VEGFA IL6 FGF2
31	Spinal Cord Injury ¹	11.93	TNF IL6 IL1B
32	Amoebiasis ³⁶	11.86	TNF IL6 IL1B
33	Hematopoietic cell lineage ³⁶	11.84	TNF IL6 IL1B
34	TNF signaling pathway ³⁶	11.78	TNF IL6 IL1B CCL5
35	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.71	TNF IL6 IL1B
36	Pertussis ³⁶	11.7	TNF IL6 IL1B
37	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.69	TNF IL6 IL1B
38	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.67	VEGFA TNF IL6 IL1B
39	Interleukin-4 and 13 signaling ⁶⁵	11.61	VEGFA TNF IL6 IL1B FGF2
40	Legionellosis ³⁶	11.54	TNF IL6 IL1B
41	Malaria ³⁶	11.46	TNF IL6 IL1B
42	Differentiation Pathway ¹	11.43	VEGFA IL6 FGF2
43	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.42	VEGFA TNF IL6 IL1B
44	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	11.4	TNF IL6 IL1B
45	Rheumatoid arthritis ³⁶	11.32	VEGFA TNF IL6 IL1B CCL5
46	African trypanosomiasis ³⁶	11.28	TNF IL6 IL1B
47	Interleukin-10 signaling ⁶⁵	11.25	TNF IL6 IL1B CCL5
48	IL-10 Pathway ⁶³	11.23	TNF IL6 IL1B
49	Development and heterogeneity of the ILC family ¹	11.18	TNF IL6 IL1B
50	Antifolate resistance ³⁶	11.14	TNF IL6 IL1B

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GO Terms for Ulcer of Lower Limbs

Cellular components related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.56	VEGFA TNF IL6 IL1B GREM1 FGF2
2	cell surface	GO:0009986	9.55	VEGFA TNFRSF10A TNF GREM1 DPP4
3	extracellular region	GO:0005576	9.28	VEGFA TNF IL6 IL1B GREM1 FGF2

Biological processes related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

(show top 50) (show all 52)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.21	VEGFA TNFRSF10A IL6 IL1B GREM1 FGF2
2	positive regulation of transcription, DNA-templated	GO:0045893	10.07	TNF IL6 IL1B GREM1 FGF2
3	immune response	GO:0006955	10.01	TNF IL6 IL1B CCL5
4	inflammatory response	GO:0006954	9.99	TNF IL6 IL1B CCL5
5	positive regulation of gene expression	GO:0010628	9.98	VEGFA TNF IL6 IL1B FGF2
6	MAPK cascade	GO:0000165	9.96	TNF IL1B FGF2 CCL5
7	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.92	VEGFA TNF FGF2 CCL5
8	cellular response to lipopolysaccharide	GO:0071222	9.89	TNF IL6 IL1B
9	positive regulation of protein phosphorylation	GO:0001934	9.89	VEGFA TNF IL1B FGF2
10	animal organ morphogenesis	GO:0009887	9.88	TNF GREM1 FGF2
11	activation of MAPK activity	GO:0000187	9.87	TNF IL1B FGF2
12	positive regulation of MAPK cascade	GO:0043410	9.86	VEGFA IL6 FGF2
13	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.86	TNF IL6 IL1B
14	positive regulation of interleukin-6 production	GO:0032755	9.85	TNF IL6 IL1B
15	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.84	VEGFA TNF IL6
16	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.84	TNF IL6 IL1B GREM1
17	cellular response to organic cyclic compound	GO:0071407	9.83	TNF IL1B CCL5
18	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.83	TNF IL1B GREM1
19	positive regulation of angiogenesis	GO:0045766	9.83	VEGFA IL1B GREM1 FGF2
20	positive regulation of T cell proliferation	GO:0042102	9.82	IL6 IL1B CCL5
21	positive regulation of smooth muscle cell proliferation	GO:0048661	9.82	TNF IL6 CCL5
22	positive regulation of MAP kinase activity	GO:0043406	9.8	VEGFA TNF FGF2
23	positive regulation of interleukin-8 production	GO:0032757	9.8	TNF IL6 IL1B
24	positive regulation of cell adhesion	GO:0045785	9.79	VEGFA TNF CCL5
25	positive regulation of cell division	GO:0051781	9.75	VEGFA IL1B FGF2
26	positive chemotaxis	GO:0050918	9.74	VEGFA FGF2 CCL5
27	protein kinase B signaling	GO:0043491	9.72	TNF IL1B CCL5
28	positive regulation of branching involved in ureteric bud morphogenesis	GO:0090190	9.71	VEGFA GREM1
29	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.71	VEGFA TNF FGF2 CCL5
30	negative regulation of lipid catabolic process	GO:0050995	9.7	TNF IL1B
31	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.7	TNF IL1B
32	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.7	TNF IL1B
33	positive regulation of DNA biosynthetic process	GO:2000573	9.69	VEGFA FGF2
34	positive regulation of leukocyte adhesion to vascular endothelial cell	GO:1904996	9.69	TNF IL6
35	positive regulation of JAK-STAT cascade	GO:0046427	9.69	TNF IL6 CCL5
36	regulation of establishment of endothelial barrier	GO:1903140	9.68	TNF IL1B
37	negative regulation of lipid storage	GO:0010888	9.67	TNF IL6
38	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.67	TNF IL1B CCL5
39	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.67	VEGFA TNF IL6 CCL5
40	negative regulation of neurogenesis	GO:0050768	9.65	TNF IL6 IL1B
41	positive regulation of peptidyl-tyrosine autophosphorylation	GO:1900086	9.64	VEGFA GREM1
42	positive regulation of fever generation	GO:0031622	9.63	TNF IL1B
43	cell migration involved in sprouting angiogenesis	GO:0002042	9.63	VEGFA GREM1 FGF2
44	cytokine-mediated signaling pathway	GO:0019221	9.63	VEGFA TNF IL6 IL1B FGF2 CCL5
45	positive regulation of epithelial tube formation	GO:1905278	9.61	VEGFA FGF2
46	positive regulation of glial cell proliferation	GO:0060252	9.61	TNF IL6 IL1B
47	sequestering of triglyceride	GO:0030730	9.6	TNF IL1B
48	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.56	TNF IL1B
49	positive regulation of neuroinflammatory response	GO:0150078	9.5	TNF IL6 IL1B
50	positive regulation of cell proliferation	GO:0008284	9.5	VEGFA IL6 IL1B GREM1 FGF2 DPP4

Molecular functions related to Ulcer of Lower Limbs according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.8	VEGFA TNFRSF10A TNF FGF2 DPP4 CCL5
2	growth factor activity	GO:0008083	9.54	VEGFA IL6 FGF2
3	protease binding	GO:0002020	9.43	TNFRSF10A TNF DPP4
4	cytokine activity	GO:0005125	9.17	VEGFA TNF IL6 IL1B GREM1 FGF2
5	vascular endothelial growth factor receptor 2 binding	GO:0043184	9.16	VEGFA GREM1
6	chemoattractant activity	GO:0042056	9.13	VEGFA FGF2 CCL5

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Sources for Ulcer of Lower Limbs

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⁷² UniProtKB/Swiss-Prot

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