MCID: ULC008
MIFTS: 23

Ulcerative Proctitis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Ulcerative Proctitis

MalaCards integrated aliases for Ulcerative Proctitis:

Name: Ulcerative Proctitis 54
Chronic Ulcerative Proctitis 74

Classifications:



External Ids:

ICD10 34 K51.2
UMLS 74 C2937222

Summaries for Ulcerative Proctitis

NIH Rare Diseases : 54 Ulcerative proctitis is a type of ulcerative colitis that affects the rectum. The symptoms of this form of proctitis may include bleeding from the rectum, the need to go to the bathroom frequently, tenesmus, diarrhea or constipation, and rectal pain. People with ulcerative proctitis tend to have episodes when the symptoms worsen and periods without symptoms, although the course of the disease varies among affected individuals. Treatment involves applying 5-aminosalicylic acid (5-ASA) or steroid creams to the rectum. In some cases, an oral version of 5-ASA is used to prevent episodes.

MalaCards based summary : Ulcerative Proctitis, also known as chronic ulcerative proctitis, is related to proctitis and colitis. An important gene associated with Ulcerative Proctitis is CRP (C-Reactive Protein). The drugs Tacrolimus and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include monocytes.

Related Diseases for Ulcerative Proctitis

Diseases related to Ulcerative Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 proctitis 11.0
2 colitis 10.5
3 ulcerative colitis 10.4
4 systemic lupus erythematosus 9.9
5 pelvic organ prolapse 9.9
6 gallbladder disease 1 9.9
7 crohn's disease 9.9
8 hemolytic anemia 9.9
9 neutropenia 9.9
10 severe congenital neutropenia 9.9
11 inflammatory bowel disease 9.9
12 lymphogranuloma venereum 9.9
13 pericarditis 9.9
14 constipation 9.9
15 intestinal pseudo-obstruction 9.9
16 lupus erythematosus 9.9
17 irritable bowel syndrome 9.9
18 lymphomatoid papulosis 9.9
19 cytomegalovirus infection 9.9

Graphical network of the top 20 diseases related to Ulcerative Proctitis:



Diseases related to Ulcerative Proctitis

Symptoms & Phenotypes for Ulcerative Proctitis

Drugs & Therapeutics for Ulcerative Proctitis

Drugs for Ulcerative Proctitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 6473866 445643 439492
2 Immunologic Factors Phase 4,Phase 3,Phase 2
3 Calcineurin Inhibitors Phase 4
4 Immunosuppressive Agents Phase 4
5
Budesonide Approved Phase 3,Phase 2 51333-22-3 5281004 63006
6 Anti-Asthmatic Agents Phase 3,Phase 2
7 Autonomic Agents Phase 3,Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
9 Cola Phase 3
10 Bronchodilator Agents Phase 3,Phase 2
11 Hormones Phase 3,Phase 2
12 glucocorticoids Phase 3,Phase 2
13 Respiratory System Agents Phase 3,Phase 2
14 Peripheral Nervous System Agents Phase 3,Phase 2
15 Anti-Inflammatory Agents Phase 3,Phase 2
16 Hormone Antagonists Phase 3,Phase 2
17 Vaccines Phase 3,Phase 2
18 Analgesics Phase 3,Phase 2
19 Mesalamine Phase 3,Phase 2 89-57-6
20 Antirheumatic Agents Phase 3,Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
22 Analgesics, Non-Narcotic Phase 3,Phase 2
23
Niclosamide Approved, Investigational, Vet_approved Phase 1, Phase 2 50-65-7 4477
24 Anthelmintics Phase 1, Phase 2
25 Antiparasitic Agents Phase 1, Phase 2
26 Anti-Infective Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis Completed NCT01418131 Phase 4 Rectal tacrolimus;Placebo
2 The Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis Completed NCT01349673 Phase 3 Budesonide Foam
3 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008423 Phase 3 Budesonide;Placebo
4 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008410 Phase 3 Budesonide;Placebo
5 Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049) Completed NCT01345240 Phase 3
6 Efficacy and Safety Study of MAX-002 Suppository Versus Placebo in Mild to Moderate Ulcerative Proctitis Terminated NCT01016262 Phase 3 MAX-002;Placebo;Canasa®
7 Clinical Trial With Mesalamine 1g Suppositories Terminated NCT01172444 Phase 3 Mesalamine;Canasa;Placebo
8 Assessment of Photopill Capsule Treatment for Safety and Feasibility in Ulcerative Proctitis Completed NCT01837615 Phase 2
9 Budesonide vs. Mesalazine vs. Budesonide/Mesalazine Suppository Combination Therapy in Acute Ulcerative Proctitis Completed NCT01966783 Phase 2 Budesonide 2 mg suppository;Budesonide 4 mg suppository;Mesalazine 1 g suppository;Budesonide 2 mg suppository/Mesalazine 1 g suppository
10 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
11 A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis Recruiting NCT03521232 Phase 1, Phase 2 Niclosamide
12 Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis Recruiting NCT03259659

Search NIH Clinical Center for Ulcerative Proctitis

Genetic Tests for Ulcerative Proctitis

Anatomical Context for Ulcerative Proctitis

MalaCards organs/tissues related to Ulcerative Proctitis:

42
Monocytes

Publications for Ulcerative Proctitis

Articles related to Ulcerative Proctitis:

(show top 50) (show all 113)
# Title Authors Year
1
Budesonide Suppositories Are Effective and Safe for Treating Acute Ulcerative Proctitis. ( 29702300 )
2019
2
Acetarsol in the management of mesalazine-refractory ulcerative proctitis: a tertiary-level care experience. ( 30499784 )
2019
3
Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis. ( 30820433 )
2019
4
Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule-1, in the Treatment for Left-Sided Ulcerative Colitis and Ulcerative Proctitis. ( 29207381 )
2018
5
Efficacy of topical 5-aminosalicylate monotherapy in patients with ulcerative proctitis with skip inflammation. ( 29205498 )
2018
6
Multi Matrix System Mesalazine Plus Rectal Mesalazine in the Treatment of Mild to Moderately Active Ulcerative Proctitis. ( 29339645 )
2018
7
Optimized Management of Ulcerative Proctitis: When and How to Use Mesalazine Suppository. ( 29393142 )
2018
8
Linear IgA bullous dermatosis associated with ulcerative proctitis: treatment challenge. ( 30261573 )
2018
9
Endoscopic progression of ulcerative proctitis to proximal disease. Can we identify predictors of progression? ( 30351984 )
2018
10
Ulcerative proctitis is a frequent location of paediatric-onset UC and not a minor disease: a population-based study. ( 27489240 )
2017
11
Azathioprine for refractory ulcerative proctitis: A retrospective multicenter study. ( 28089625 )
2017
12
Efficacy of Rectal Tacrolimus for Induction Therapy in Patients With Resistant Ulcerative Proctitis. ( 28286194 )
2017
13
Therapeutic requirements in active ulcerative proctitis: A single-centre study. ( 28666605 )
2017
14
Clinical Predictors and Natural History of Disease Extension in Patients with Ulcerative Proctitis. ( 28922252 )
2017
15
The role of confocal laser endomicroscopy in assessing mucosal healing in patients with ulcerative proctitis. ( 29186737 )
2017
16
Clinical pattern and progression of ulcerative proctitis in the Japanese population: a retrospective study of incidence and risk factors influencing progression. ( 26663677 )
2016
17
Baseline Oral 5-ASA Use and Efficacy and Safety of Budesonide Foam in Patients with Ulcerative Proctitis and Ulcerative Proctosigmoiditis: Analysis of 2 Phase 3 Studies. ( 27416045 )
2016
18
Oral 5-Aminosalicylate, Mesalamine Suppository, and Mesalamine Enema as Initial Therapy for Ulcerative Proctitis in Clinical Practice with Quality of Care Implications. ( 27446860 )
2016
19
Improvement of Refractory Ulcerative Proctitis With Sacral Nerve Stimulation. ( 25930972 )
2015
20
Budesonide Foam Has a Favorable Safety Profile for Inducing Remission in Mild-to-Moderate Ulcerative Proctitis or Proctosigmoiditis. ( 26386854 )
2015
21
Oral 5-aminosalicylate, mesalamine suppository and mesalamine enema as initial therapy for ulcerative proctitis in clinical practice with quality of care implications. ( 26469062 )
2015
22
Budesonide foam induces remission in patients with mild to moderate ulcerative proctitis and ulcerative proctosigmoiditis. ( 25644096 )
2015
23
Pathogenesis, diagnosis, and management of ulcerative proctitis, chronic radiation proctopathy, and diversion proctitis. ( 25687266 )
2015
24
A case of appendectomy as main therapeutic intervention for complex co-morbid ulcerative proctitis. ( 25690705 )
2015
25
Successful treatment for ulcerative proctitis with rectal tacrolimus in an 8-year-old girl with intolerance to mesalamine. ( 26185880 )
2014
26
Proximal disease extension and related predicting factors in ulcerative proctitis. ( 24325564 )
2014
27
Gastrointestinal symptoms resembling ulcerative proctitis caused by larvae of the drone fly Eristalis tenax. ( 24766340 )
2014
28
Ulcerative proctitis: an update on the pharmacotherapy and management. ( 24837209 )
2014
29
Drug therapies for ulcerative proctitis: systematic review and meta-analysis. ( 25072502 )
2014
30
Ulcerative proctitis in out-patient practice: an unexpected clinical challenge. ( 25176055 )
2014
31
Comparison of Xilei-san, a Chinese herbal medicine, and dexamethasone in mild/moderate ulcerative proctitis: a double-blind randomized clinical trial. ( 23383973 )
2013
32
A rare case of ulcerative proctitis associated with type B lymphomatoid papulosis and superimposed human cytomegalovirus infection. ( 22715829 )
2012
33
Treatment of new-onset ulcerative colitis and ulcerative proctitis: a retrospective study. ( 22690748 )
2012
34
Placebo controlled evaluation of Xilei San, a herbal preparation in patients with intractable ulcerative proctitis. ( 22775479 )
2012
35
Psoriatic colitis mimicking ulcerative proctitis in an elderly patient. ( 22884084 )
2012
36
Expanding the therapeutic armamentarium of ulcerative proctitis. ( 23167520 )
2012
37
Should maintenance therapy be performed in ulcerative proctitis? How long should it be continued? ( 23576086 )
2012
38
A multicenter, randomized study to evaluate the efficacy and safety of mesalamine suppositories 1 g at bedtime and 500 mg Twice daily in patients with active mild-to-moderate ulcerative proctitis. ( 20676771 )
2011
39
Hydrogen peroxide exposure mimicking ulcerative proctitis. ( 21130717 )
2011
40
Appendicectomy as a potential therapy for refractory ulcerative proctitis. ( 21679209 )
2011
41
Recurrent pericarditis in a patient with ulcerative proctitis due to mesalazine suppositories. ( 20237787 )
2010
42
Efficacy and safety of mesalamine suppositories for treatment of ulcerative proctitis in children and adolescents. ( 20848454 )
2010
43
Infliximab for refractory ulcerative proctitis. ( 20222911 )
2010
44
Clinical trial: a novel high-dose 1 g mesalamine suppository (Salofalk) once daily is as efficacious as a 500-mg suppository thrice daily in active ulcerative proctitis. ( 20310020 )
2010
45
Topically administered infliximab can work in ulcerative proctitis despite the ineffectiveness of intravenous induction therapy. ( 19436284 )
2009
46
Appendicectomy as a therapy for ulcerative proctitis. ( 19584834 )
2009
47
Emerging issues in ulcerative colitis and ulcerative proctitis: individualizing treatment to maximize outcomes. ( 20574506 )
2009
48
Ulcerative proctitis: a review of pharmacotherapy and management. ( 18345952 )
2008
49
A combination of rectal beclomethasone diproprionate and mesalazine in ulcerative proctitis. ( 18415762 )
2008
50
Appendiceal orifice inflammation and ulcerative proctitis. ( 18674731 )
2008

Variations for Ulcerative Proctitis

Expression for Ulcerative Proctitis

Search GEO for disease gene expression data for Ulcerative Proctitis.

Pathways for Ulcerative Proctitis

GO Terms for Ulcerative Proctitis

Sources for Ulcerative Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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