MCID: ULC008
MIFTS: 24

Ulcerative Proctitis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Ulcerative Proctitis

MalaCards integrated aliases for Ulcerative Proctitis:

Name: Ulcerative Proctitis 53
Chronic Ulcerative Proctitis 73

Classifications:



External Ids:

ICD10 33 K51.2
UMLS 73 C2937222

Summaries for Ulcerative Proctitis

NIH Rare Diseases : 53 Ulcerative proctitis is a type of ulcerative colitis that affects the rectum. The symptoms of this form of proctitis may include bleeding from the rectum, the need to go to the bathroom frequently, tenesmus, diarrhea or constipation, and rectal pain. People with ulcerative proctitis tend to have episodes when the symptoms worsen and periods without symptoms, although the course of the disease varies among affected individuals. Treatment involves applying 5-aminosalicylic acid (5-ASA) or steroid creams to the rectum. In some cases, an oral version of 5-ASA is used to prevent episodes.

MalaCards based summary : Ulcerative Proctitis, also known as chronic ulcerative proctitis, is related to proctitis and colitis. An important gene associated with Ulcerative Proctitis is CRP (C-Reactive Protein). The drugs Tacrolimus and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include monocytes.

Related Diseases for Ulcerative Proctitis

Diseases related to Ulcerative Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 proctitis 10.9
2 colitis 10.5
3 ulcerative colitis 10.4
4 systemic lupus erythematosus 9.9
5 pelvic organ prolapse 9.9
6 crohn's disease 9.9
7 hemolytic anemia 9.9
8 neutropenia 9.9
9 inflammatory bowel disease 9.9
10 lymphogranuloma venereum 9.9
11 pericarditis 9.9
12 constipation 9.9
13 intestinal pseudo-obstruction 9.9
14 lupus erythematosus 9.9
15 linear iga disease 9.9
16 lymphomatoid papulosis 9.9
17 cytomegalovirus infection 9.9

Graphical network of the top 20 diseases related to Ulcerative Proctitis:



Diseases related to Ulcerative Proctitis

Symptoms & Phenotypes for Ulcerative Proctitis

Drugs & Therapeutics for Ulcerative Proctitis

Drugs for Ulcerative Proctitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
2 Immunologic Factors Phase 4,Phase 3,Phase 2
3 Immunosuppressive Agents Phase 4
4 Calcineurin Inhibitors Phase 4
5
Budesonide Approved Phase 3,Phase 2 51333-22-3 63006 5281004
6 glucocorticoids Phase 3,Phase 2
7 Bronchodilator Agents Phase 3,Phase 2
8 Hormones Phase 3,Phase 2
9 Peripheral Nervous System Agents Phase 3,Phase 2
10 Respiratory System Agents Phase 3,Phase 2
11 Hormone Antagonists Phase 3,Phase 2
12 Anti-Inflammatory Agents Phase 3,Phase 2
13 Autonomic Agents Phase 3,Phase 2
14 Anti-Asthmatic Agents Phase 3,Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
16 Cola Phase 3
17 Vaccines Phase 3,Phase 2
18 Mesalamine Phase 3,Phase 2 89-57-6
19 Analgesics Phase 3,Phase 2
20 Analgesics, Non-Narcotic Phase 3,Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
22 Antirheumatic Agents Phase 3,Phase 2
23
Niclosamide Approved, Investigational, Vet_approved Phase 1, Phase 2 50-65-7 4477
24 Anti-Infective Agents Phase 1, Phase 2
25 Antiparasitic Agents Phase 1, Phase 2
26 Anthelmintics Phase 1, Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis Completed NCT01418131 Phase 4 Rectal tacrolimus;Placebo
2 The Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis Completed NCT01349673 Phase 3 Budesonide Foam
3 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008423 Phase 3 Budesonide;Placebo
4 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008410 Phase 3 Budesonide;Placebo
5 Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049) Completed NCT01345240 Phase 3
6 Efficacy and Safety Study of MAX-002 Suppository Versus Placebo in Mild to Moderate Ulcerative Proctitis Terminated NCT01016262 Phase 3 MAX-002;Placebo;Canasa®
7 Clinical Trial With Mesalamine 1g Suppositories Terminated NCT01172444 Phase 3 Mesalamine;Canasa;Placebo
8 Assessment of Photopill Capsule Treatment for Safety and Feasibility in Ulcerative Proctitis Completed NCT01837615 Phase 2
9 Budesonide vs. Mesalazine vs. Budesonide/Mesalazine Suppository Combination Therapy in Acute Ulcerative Proctitis Completed NCT01966783 Phase 2 Budesonide 2 mg suppository;Budesonide 4 mg suppository;Mesalazine 1 g suppository;Budesonide 2 mg suppository/Mesalazine 1 g suppository
10 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
11 A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis Recruiting NCT03521232 Phase 1, Phase 2 Niclosamide
12 Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis Recruiting NCT03259659

Search NIH Clinical Center for Ulcerative Proctitis

Genetic Tests for Ulcerative Proctitis

Anatomical Context for Ulcerative Proctitis

MalaCards organs/tissues related to Ulcerative Proctitis:

41
Monocytes

Publications for Ulcerative Proctitis

Articles related to Ulcerative Proctitis:

(show top 50) (show all 115)
# Title Authors Year
1
Budesonide Suppositories Are Effective and Safe for Treating Acute Ulcerative Proctitis. ( 29702300 )
2018
2
Optimized Management of Ulcerative Proctitis: When and How to Use Mesalazine Suppository. ( 29393142 )
2018
3
Multi Matrix System Mesalazine Plus Rectal Mesalazine in the Treatment of Mild to Moderately Active Ulcerative Proctitis. ( 29339645 )
2018
4
Linear IgA bullous dermatosis associated with ulcerative proctitis: treatment challenge. ( 30261573 )
2018
5
Endoscopic progression of ulcerative proctitis to proximal disease. Can we identify predictors of progression? ( 30351984 )
2018
6
Acetarsol in the management of mesalazine-refractory ulcerative proctitis: a tertiary-level care experience. ( 30499784 )
2018
7
Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule-1, in the Treatment for Left-Sided Ulcerative Colitis and Ulcerative Proctitis. ( 29207381 )
2017
8
Efficacy of Rectal Tacrolimus for Induction Therapy in Patients With Resistant Ulcerative Proctitis. ( 28286194 )
2017
9
Therapeutic requirements in active ulcerative proctitis: A single-centre study. ( 28666605 )
2017
10
Efficacy of topical 5-aminosalicylate monotherapy in patients with ulcerative proctitis with skip inflammation. ( 29205498 )
2017
11
The role of confocal laser endomicroscopy in assessing mucosal healing in patients with ulcerative proctitis. ( 29186737 )
2017
12
Clinical Predictors and Natural History of Disease Extension in Patients with Ulcerative Proctitis. ( 28922252 )
2017
13
Azathioprine for refractory ulcerative proctitis: A retrospective multicenter study. ( 28089625 )
2016
14
Oral 5-Aminosalicylate, Mesalamine Suppository, and Mesalamine Enema as Initial Therapy for Ulcerative Proctitis in Clinical Practice with Quality of Care Implications. ( 27446860 )
2016
15
Baseline Oral 5-ASA Use and Efficacy and Safety of Budesonide Foam in Patients with Ulcerative Proctitis and Ulcerative Proctosigmoiditis: Analysis of 2 Phase 3 Studies. ( 27416045 )
2016
16
Ulcerative proctitis is a frequent location of paediatric-onset UC and not a minor disease: a population-based study. ( 27489240 )
2016
17
Clinical pattern and progression of ulcerative proctitis in the Japanese population: a retrospective study of incidence and risk factors influencing progression. ( 26663677 )
2016
18
A case of appendectomy as main therapeutic intervention for complex co-morbid ulcerative proctitis. ( 25690705 )
2015
19
P587. Tacrolimus suppositories in therapy-resistant ulcerative proctitis - a single center experience. ( 25718087 )
2015
20
P461. Therapeutic requirements and health resources in the treatment of clinically active ulcerative proctitis. ( 25717954 )
2015
21
Improvement of Refractory Ulcerative Proctitis With Sacral Nerve Stimulation. ( 25930972 )
2015
22
Oral 5-aminosalicylate, mesalamine suppository and mesalamine enema as initial therapy for ulcerative proctitis in clinical practice with quality of care implications. ( 26469062 )
2015
23
Pathogenesis, diagnosis, and management of ulcerative proctitis, chronic radiation proctopathy, and diversion proctitis. ( 25687266 )
2015
24
P214. Ulcerative Proctitis: Predictors and outcomes of disease extension in UC. ( 25717682 )
2015
25
Budesonide foam induces remission in patients with mild to moderate ulcerative proctitis and ulcerative proctosigmoiditis. ( 25644096 )
2015
26
Budesonide Foam Has a Favorable Safety Profile for Inducing Remission in Mild-to-Moderate Ulcerative Proctitis or Proctosigmoiditis. ( 26386854 )
2015
27
Gastrointestinal symptoms resembling ulcerative proctitis caused by larvae of the drone fly Eristalis tenax. ( 24766340 )
2014
28
Proximal disease extension and related predicting factors in ulcerative proctitis. ( 24325564 )
2014
29
Ulcerative proctitis in out-patient practice: an unexpected clinical challenge. ( 25176055 )
2014
30
Ulcerative proctitis: an update on the pharmacotherapy and management. ( 24837209 )
2014
31
Drug Therapies for Ulcerative Proctitis: Systematic Review and Meta-analysis. ( 25072502 )
2014
32
Successful treatment for ulcerative proctitis with rectal tacrolimus in an 8-year-old girl with intolerance to mesalamine. ( 26185880 )
2014
33
Comparison of Xilei-san, a Chinese herbal medicine, and dexamethasone in mild/moderate ulcerative proctitis: a double-blind randomized clinical trial. ( 23383973 )
2013
34
Expanding the therapeutic armamentarium of ulcerative proctitis. ( 23167520 )
2012
35
Psoriatic colitis mimicking ulcerative proctitis in an elderly patient. ( 22884084 )
2012
36
A rare case of ulcerative proctitis associated with type B lymphomatoid papulosis and superimposed human cytomegalovirus infection. ( 22715829 )
2012
37
Treatment of new-onset ulcerative colitis and ulcerative proctitis: a retrospective study. ( 22690748 )
2012
38
Should maintenance therapy be performed in ulcerative proctitis? How long should it be continued? ( 23576086 )
2012
39
Placebo controlled evaluation of Xilei San, a herbal preparation in patients with intractable ulcerative proctitis. ( 22775479 )
2012
40
Appendicectomy as a potential therapy for refractory ulcerative proctitis. ( 21679209 )
2011
41
Hydrogen peroxide exposure mimicking ulcerative proctitis. ( 21130717 )
2011
42
A multicenter, randomized study to evaluate the efficacy and safety of mesalamine suppositories 1 g at bedtime and 500 mg Twice daily in patients with active mild-to-moderate ulcerative proctitis. ( 20676771 )
2011
43
Infliximab for refractory ulcerative proctitis. ( 20222911 )
2010
44
Recurrent pericarditis in a patient with ulcerative proctitis due to mesalazine suppositories. ( 20237787 )
2010
45
Clinical trial: a novel high-dose 1 g mesalamine suppository (Salofalk) once daily is as efficacious as a 500-mg suppository thrice daily in active ulcerative proctitis. ( 20310020 )
2010
46
Efficacy and safety of mesalamine suppositories for treatment of ulcerative proctitis in children and adolescents. ( 20848454 )
2010
47
Emerging issues in ulcerative colitis and ulcerative proctitis: individualizing treatment to maximize outcomes. ( 20574506 )
2009
48
Appendicectomy as a therapy for ulcerative proctitis. ( 19584834 )
2009
49
Topically administered infliximab can work in ulcerative proctitis despite the ineffectiveness of intravenous induction therapy. ( 19436284 )
2009
50
A combination of rectal beclomethasone diproprionate and mesalazine in ulcerative proctitis. ( 18415762 )
2008

Variations for Ulcerative Proctitis

Expression for Ulcerative Proctitis

Search GEO for disease gene expression data for Ulcerative Proctitis.

Pathways for Ulcerative Proctitis

GO Terms for Ulcerative Proctitis

Sources for Ulcerative Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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