Aliases & Classifications for Ulcerative Stomatitis

MalaCards integrated aliases for Ulcerative Stomatitis:

Name: Ulcerative Stomatitis 12 15 70
Minor Oral Aphthous Ulceration 70
Stomatitis Ulcerative 54
Aphthous Stomatitis 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9673
MeSH 44 D005892
NCIt 50 C35039
SNOMED-CT 67 450005
ICD10 32 K12.1
UMLS 70 C0038363 C0038367 C0585213

Summaries for Ulcerative Stomatitis

MalaCards based summary : Ulcerative Stomatitis, also known as minor oral aphthous ulceration, is related to stomatitis and lichen planus, and has symptoms including snoring and halitosis. An important gene associated with Ulcerative Stomatitis is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Apoptosis Modulation and Signaling and Direct p53 effectors. The drugs Chlorhexidine and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and thymus.

Related Diseases for Ulcerative Stomatitis

Diseases related to Ulcerative Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 stomatitis 10.9
2 lichen planus 10.5
3 oral lichen planus 10.4
4 necrotizing sialometaplasia 10.4 TP63 TP53
5 gingivitis 10.4
6 noma 10.3
7 anal carcinoma in situ 10.3 TP53 CD4
8 wells syndrome 10.3 TP63 TP53
9 penis squamous cell carcinoma 10.3 TP53 CD4
10 neurofibrosarcoma 10.3 TP73 TP53
11 orofacial cleft 8 10.3 TP73 TP63
12 vaginal cancer 10.3 TP53 CD4
13 anal squamous cell carcinoma 10.3 TP73 TP53
14 vulvar disease 10.3 TP53 CD4
15 papilledema 10.2 TP53 CD4
16 myasthenic syndrome, congenital, 17 10.2 TP53 CD8A
17 cork-handlers' disease 10.2 CD8A CD4
18 necrotic uveal melanoma 10.2 CD8A CD4
19 early yaws 10.2 CD8A CD4
20 cervical squamous cell carcinoma 10.2 TP73 TP63 TP53
21 ventilation pneumonitis 10.2 CD8A CD4
22 diffuse infiltrative lymphocytosis syndrome 10.2 CD8A CD4
23 latent syphilis 10.2 CD8A CD4
24 type 1 diabetes mellitus 23 10.2 CD8A CD4
25 autoimmune lymphoproliferative syndrome, type iia 10.2 CD8A CD4
26 parapsoriasis 10.2 CD8A CD4
27 gastroduodenitis 10.2 CD8A CD4
28 duodenitis 10.2 CD8A CD4
29 primary syphilis 10.2 CD8A CD4
30 norwegian scabies 10.2 CD8A CD4
31 bird fancier's lung 10.2 CD8A CD4
32 skin sarcoidosis 10.2 CD8A CD4
33 metal allergy 10.2 CD8A CD4
34 variola major 10.2 CD8A CD4
35 follicular mucinosis 10.2 CD8A CD4
36 tertiary syphilis 10.2 CD8A CD4
37 mucositis 10.2
38 spongiotic dermatitis 10.2 CD8A CD4
39 acute retinal necrosis syndrome 10.2 CD8A CD4
40 cerebral lymphoma 10.2 CD8A CD4
41 oral tuberculosis 10.2 CD8A CD4
42 cerebritis 10.2 CD8A CD4
43 invasive malignant thymoma 10.2 CD8A CD4
44 west nile encephalitis 10.2 CD8A CD4
45 granulomatous hepatitis 10.2 CD8A CD4
46 exanthema subitum 10.2 CD8A CD4
47 immunodeficiency 36 10.2 CD8A CD4
48 viral exanthem 10.2 CD8A CD4
49 secondary syphilis 10.2 CD8A CD4
50 acute interstitial pneumonia 10.2 CD8A CD4

Comorbidity relations with Ulcerative Stomatitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Ulcerative Stomatitis:



Diseases related to Ulcerative Stomatitis

Symptoms & Phenotypes for Ulcerative Stomatitis

UMLS symptoms related to Ulcerative Stomatitis:


snoring; halitosis

Drugs & Therapeutics for Ulcerative Stomatitis

Drugs for Ulcerative Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 3 55-56-1 9552079 2713
2
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
3
Apremilast Approved, Investigational Phase 3 608141-41-9 11561674
4
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 68-26-8, 11103-57-4 445354
5 Retinol palmitate Phase 3
6 retinol Phase 3
7 Adjuvants, Immunologic Phase 3
8 Viscosupplements Phase 3
9 Chlorhexidine gluconate Phase 3
10 Protective Agents Phase 3
11 Immunologic Factors Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Analgesics Phase 3
14 Antirheumatic Agents Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Anti-Inflammatory Agents, Non-Steroidal Phase 3
17
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
18
Ibuprofen Approved Phase 2 15687-27-1 3672
19
Histamine Approved, Investigational Phase 2 51-45-6, 75614-87-8 774
20
Promethazine Approved, Investigational Phase 2 60-87-7 4927
21
Zinc Approved, Investigational Phase 2 7440-66-6 32051
22
Zinc sulfate Approved, Investigational Phase 2 7733-02-0
23
Ethanol Approved Phase 2 64-17-5 702
24 Skullcap Phase 1, Phase 2
25 Omega 3 Fatty Acid Phase 2
26 Acidophilus Phase 2
27 Gastrointestinal Agents Phase 2
28 Neurotransmitter Agents Phase 2
29 Hypnotics and Sedatives Phase 2
30 Anesthetics Phase 2
31 Anesthetics, Local Phase 2
32 Antiemetics Phase 2
33 Anti-Allergic Agents Phase 2
34 Cyclooxygenase Inhibitors Phase 2
35 Histamine Antagonists Phase 2
36 Dermatologic Agents Phase 2
37
Histamine Phosphate Phase 2 51-74-1 65513
38 Histamine H1 Antagonists Phase 2
39 Sodium Benzoate Phase 2
40
Chamomile Approved, Experimental, Investigational Phase 1
41
Coumarin Experimental Phase 1 91-64-5 323
42 Parasympatholytics Phase 1
43
Pentoxifylline Approved, Investigational 6493-05-6 4740
44
Dexamethasone Approved, Investigational, Vet_approved Early Phase 1 50-02-2 5743
45
Metronidazole Approved Early Phase 1 443-48-1 4173
46
Nystatin Approved, Vet_approved Early Phase 1 1400-61-9 11953884
47
Dexamethasone acetate Approved, Investigational, Vet_approved Early Phase 1 1177-87-3
48
Tetracycline Approved, Vet_approved Early Phase 1 60-54-8 5353990
49
Zinc oxide Approved Early Phase 1 1314-13-2
50
Cetylpyridinium Approved 7773-52-6

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Prevention of Recurrent Aphthous Stomatitis Using Vitamins Completed NCT00527306 Phase 3
2 Effectiveness of Topical Hyaluronic Acid Versus Chlorhexidine Mouthwashes in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Clinical Trial Completed NCT04265001 Phase 3 Hyaluronic acid in the form of hyaluronan sodium 25 mg/100 ml as a mouthwash
3 Randomized Double Blind Controlled Trial Comparing the Safety and Efficacy of Apremilast Versus Placebo in Severe Forms of Recurrent Aphthous Stomatitis Not yet recruiting NCT04227314 Phase 3 Apremilast;Placebo oral tablet
4 Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome (Acute Pericoronitis, Minor Recurrent Aphthous Stomatitis and Recurrent Herpes Simplex Labialis) Unknown status NCT03469232 Phase 1, Phase 2 Huanglian-Jiedu Decoction
5 Therapeutic Effect of Systemic Omega-3 Polyunsaturated Fatty Acids On Quality of Life in Patients Suffering From Recurrent Aphthous Stomatitis Unresponsive to Topical Therapy. Unknown status NCT01831453 Phase 2 omega-3;placebo
6 Treatment of Idiopathic and Recurrent Aphthous Stomatitis by a Probiotic, the Lactobacillus Rhamnosus Lcr35® : a Randomized, Double Blind and Placebo-controlled Trial Completed NCT02789605 Phase 2 Bacilor;Placebo
7 Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis Completed NCT01652625 Phase 2 Yunnan Baiyao toothpaste;Placebo toothpaste
8 Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis Completed NCT01293968 Phase 2 Ibuprofen, Diphenhydramine and Aluminium MgS;Diphenhydramine and Aluminium MgS
9 Zinc Sulphate in Treatment of Recurrent Aphthous Stomatitis Completed NCT01210014 Phase 2 zinc sulphate 220mg/day in one dosage;placebo: one dosage
10 Muco-bioadhesive Gel Containing Basil Extract (Ocimum Basilicum) in the Management of Recurrent Aphthous Stomatitis: A Randomized Clinical Study Not yet recruiting NCT04710888 Phase 2 use of basil extract gel in treatment of aphthus ulcer
11 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Unknown status NCT02775994 Phase 1 Canakinumab
12 Phase 1 Evaluation of Therapeutic Effect of Chamomilla Tincture Mouthwash on Oral Aphthae Completed NCT01122147 Phase 1 chamomilla tincture mouthwash;placebo mouthwash
13 Characterisation of the Salivary and Faecal Microbiome in Patients With Recurrent Aphthous Stomatitis Before and After Treatment With Probiotics Unknown status NCT02976922
14 Effects of a Night Guard on Aphthous Stomatitis Completed NCT02890524
15 Patient Evaluation and Treatment of Oral Soft Tissue Diseases According to Generally Available, Standard Procedures and Therapeutic Modalities Completed NCT00001601
16 A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis Completed NCT00315679 Pentoxifylline (also known as oxpentifylline)
17 Safety, Galenic Acceptability and Efficacy of GV-328 Lozenges in Children With Oral Aphthosis Completed NCT04677062 GV-328
18 The Effect of 2-DeNT Oral Topical Powder on Minor Recurrent Aphthous Ulcer Completed NCT02142543 Early Phase 1 2-DeNT powder;Placebo Comparator
19 Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis Completed NCT00288769 daily sublingual tablets Vitamin B12 1000 mcg versus placebo
20 Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis : a Randomised Clinical Trial Completed NCT01501409
21 Evaluation of the Effect of Probiotic Lozenges in the Treatment of Recurrent Aphthous Stomatitis: a Randomized, Controlled Clinical Trial Completed NCT04383236 Oracure oral gel
22 Treatment of Recurrent Aphthous Stomatitis With Er,Cr:YSGG Laser Irradiation: A Randomized Controlled Clinical Study Completed NCT02925182
23 Comparison of Curcumin and NanoCurcumin in Recurrent Aphthous Stomatitis Completed NCT04385979
24 A Pilot Study Evaluating the Efficacy of Apremilast in the Treatment of Subjects With Severe Recurrent Aphthous Stomatitis (RAS) Active, not recruiting NCT03690544 Early Phase 1 Apremilast 30mg
25 Influence of Different Doses of the Vitamin B12 on Recurrent Aphthous Stomatitis Terminated NCT01127724 vitamin B12 treatment
26 Salivary Catecholamines in Aphthous Stomatitis Withdrawn NCT00556686

Search NIH Clinical Center for Ulcerative Stomatitis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Thalidomide

Genetic Tests for Ulcerative Stomatitis

Anatomical Context for Ulcerative Stomatitis

MalaCards organs/tissues related to Ulcerative Stomatitis:

40
Bone Marrow, Bone, Thymus, Lung, Skin, Myeloid, Tongue

Publications for Ulcerative Stomatitis

Articles related to Ulcerative Stomatitis:

(show top 50) (show all 184)
# Title Authors PMID Year
1
CUSP/p63 expression in rat and human tissues. 61 54
11532371 2001
2
Characterization of an autoantigen associated with chronic ulcerative stomatitis: the CUSP autoantigen is a member of the p53 family. 61 54
10469295 1999
3
Novel combination therapy of hydroxychloroquine and topical tacrolimus for chronic ulcerative stomatitis. 61
32970835 2021
4
HPLC methods for choloroquine determination in biological samples and pharmaceutical products. 61
33738722 2021
5
Hydroxychloroquine and the treatment of Sjogren syndrome, chronic ulcerative stomatitis, and oral lichen planus in the age of COVID-19. 61
32654931 2021
6
Identification of a Novel α-herpesvirus Associated with Ulcerative Stomatitis in Donkeys. 61
33219790 2020
7
Ulcerative Stomatitis as the Sole Manifestation of Progesterone Hypersensitivity. 61
33274071 2020
8
Prevalence of ulcerative stomatitis in arbovirus infections in a Brazilian Northeast population. 61
33037807 2020
9
Uraemic Encephalopathy in a Persian Cat with Chronic Kidney Disease. 61
33222866 2020
10
Bullous Sweet's syndrome in a patient with ulcerative colitis: a rare case report. 61
32975303 2020
11
A molecular and pathological study of peste des petits ruminants virus (PPRV) from field outbreaks in Palestine, 2017-2019. 61
32145152 2020
12
Immunopathogenesis of canine chronic ulcerative stomatitis. 61
31923271 2020
13
Chronic ulcerative stomatitis: A systematic review of the clinical and microscopic features. 61
31655827 2019
14
Seventeen New Cases of Chronic Ulcerative Stomatitis with Literature Review. 61
30374883 2019
15
Chronic ulcerative stomatitis: A comprehensive review and proposal for diagnostic criteria. 61
30457193 2019
16
Oral lichen planus: A disease or a spectrum of tissue reactions? Types, causes, diagnostic algorhythms, prognosis, management strategies. 61
31090143 2019
17
Chronic ulcerative stomatitis: Case series of an under-recognized entity. 61
30159907 2018
18
Identification of bacteria present in ulcerative stomatitis lesions of captive sea turtles Chelonia mydas. 61
29934703 2018
19
Successful treatment of oral Crohn's disease by anti-TNF-alpha dose escalation - a case report. 61
29914414 2018
20
Is chronic ulcerative stomatitis a variant of lichen planus, or a distinct disease? 61
28186659 2017
21
Clinicopathologic significance of in vivo antinuclear autoantibodies in oral mucosal biopsies. 61
28939244 2017
22
Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis. 61
28113036 2017
23
DIPHTHERITIC STOMATITIS IN YELLOW-EYED PENGUINS (MEGADYPTES ANTIPODES) IN NEW ZEALAND. 61
27788054 2017
24
Atypical methotrexate ulcerative stomatitis with features of lymphoproliferative like disorder: Report of a rare ciprofloxacin-induced case and review of the literature. 61
27957282 2016
25
Unilateral hemorrhagic maculopathy: An uncommon manifestation of hand, foot, and mouth disease. 61
27905343 2016
26
The diagnostic challenges of separating chronic ulcerative stomatitis from oral lichen planus. 61
26337216 2015
27
Transplacental Transmission of Ovine Herpesvirus 2 in Cattle with Sheep-associated Malignant Catarrhal Fever. 61
26604083 2015
28
[Noma]. 61
26235765 2015
29
Oral ulcerations as a sequela of tacrolimus and mycophenolate mofetil therapy. 61
25457894 2014
30
Herpes simplex virus type 1 infection in two pet marmosets in Japan. 61
25649955 2014
31
Experimental infection of sheep and goats with a recent isolate of peste des petits ruminants virus from Kurdistan. 61
24908276 2014
32
Oral lichenoid tissue reactions: diagnosis and classification. 61
24524807 2014
33
[Cowpox virus infection in an alpaca (Vicugna pacos) - clinical symptoms, laboratory diagnostic findings and pathological changes]. 61
24920091 2014
34
Noma in an immunocompromised patient. 61
24192747 2013
35
Ulcerative lesions as a rare cause of laryngotracheitis in the pediatric population. 61
23535210 2013
36
Prevalence of oral lesions of autoimmune etiology in patients with primary Sjogren's syndrome. 61
23279206 2013
37
Cutaneous changes in patients with chronic renal failure on hemodialysis. 61
22335460 2012
38
Erythema multiforme and epitheliotropic T-cell lymphoma in the oral cavity of dogs: 1989 to 2009. 61
22784253 2012
39
Oral manifestations of human immunodeficiency virus in children: An institutional study at highly active antiretroviral therapy centre in India. 61
22923890 2012
40
Tp63 in oral development, neoplasia, and autoimmunity. 61
21646640 2012
41
Chronic ulcerative stomatitis: evidence of autoimmune pathogenesis. 61
21459019 2011
42
Chronic ulcerative stomatitis: a distinct clinical entity? 61
21874892 2011
43
Lamb pays lip service: two cases of ecthyma contagiosum (orf). 61
21515534 2011
44
Debilitating clinical disease in a wild-born captive western lowland gorilla (Gorilla gorilla gorilla) co-infected with varicella zoster virus (VZV) and simian T-lymphotropic virus (STLV). 61
21370655 2010
45
[A toxic reaction of the oral mucosa to alendronate (Fosamax)]. 61
20726498 2010
46
Pathology in practice. Severe, chronic, focal, granulomatous, nodular and ulcerative stomatitis with myxosporidia (Myxobolus sp.). 61
20225971 2010
47
ELISA test for p63 antibodies in chronic ulcerative stomatitis. 61
19682320 2010
48
Oral manifestations of HIV/AIDS in China: a review. 61
19404695 2009
49
Calcifying epithelial odontogenic tumor of the maxilla with ulcerative stomatitis: a case report. 61
18790551 2009
50
Oral ulcers in HIV-positive Peruvian patients: an immunohistochemical and in situ hybridization study. 61
19192057 2009

Variations for Ulcerative Stomatitis

Expression for Ulcerative Stomatitis

Search GEO for disease gene expression data for Ulcerative Stomatitis.

Pathways for Ulcerative Stomatitis

GO Terms for Ulcerative Stomatitis

Biological processes related to Ulcerative Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.56 TP73 TP63 TP53 NOL3
2 regulation of signal transduction by p53 class mediator GO:1901796 9.5 TP73 TP63 TP53
3 positive regulation of cell cycle arrest GO:0071158 9.43 TP73 TP53
4 intrinsic apoptotic signaling pathway GO:0097193 9.4 TP53 NOL3
5 cell aging GO:0007569 9.37 TP63 TP53
6 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.33 TP73 TP63 TP53
7 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.13 TP73 TP63 TP53
8 protein tetramerization GO:0051262 8.8 TP73 TP63 TP53

Molecular functions related to Ulcerative Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 9.13 TP73 TP63 TP53
2 MDM2/MDM4 family protein binding GO:0097371 8.8 TP73 TP63 TP53

Sources for Ulcerative Stomatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....