MCID: UMB002
MIFTS: 42

Umbilical Hernia

Categories: Gastrointestinal diseases

Aliases & Classifications for Umbilical Hernia

Summaries for Umbilical Hernia

Disease Ontology : 12 A intestinal disease characterized by the protrusion by part of the intestine though an opening in the abdominal muscles.

MalaCards based summary : Umbilical Hernia, also known as hernia, umbilical, is related to smith-kingsmore syndrome and shprintzen-goldberg craniosynostosis syndrome. An important gene associated with Umbilical Hernia is PLOD1 (Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 1), and among its related pathways/superpathways are MECP2 and Associated Rett Syndrome and EGFR Transactivation by Gastrin. The drugs Ibuprofen and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 An umbilical hernia is a health condition where the abdominal wall behind the navel is damaged. It may... more...

Related Diseases for Umbilical Hernia

Diseases related to Umbilical Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 smith-kingsmore syndrome 11.8
2 shprintzen-goldberg craniosynostosis syndrome 11.3
3 carpenter syndrome 2 11.1
4 hypothyroidism, congenital, nongoitrous, 2 11.0
5 fraser syndrome 1 11.0
6 gapo syndrome 11.0
7 3mc syndrome 3 11.0
8 3mc syndrome 1 11.0
9 3mc syndrome 2 11.0
10 weaver syndrome 11.0
11 mental retardation, x-linked, syndromic, martin-probst type 11.0
12 achondrogenesis, type ib 11.0
13 fontaine progeroid syndrome 11.0
14 chromosome 6q11-q14 deletion syndrome 11.0
15 tatton-brown-rahman syndrome 11.0
16 cohen-gibson syndrome 11.0
17 hyperekplexia 4 11.0
18 simpson-golabi-behmel syndrome 11.0
19 bamforth syndrome 11.0
20 central congenital hypothyroidism 11.0
21 peripheral resistance to thyroid hormones 11.0
22 silver-russell syndrome due to a point mutation 10.4 CDKN1C IGF2
23 hypomelanosis of ito 10.3 IGF2 PLOD1
24 silver-russell syndrome due to an imprinting defect of 11p15 10.3 H19 IGF2
25 silver-russell syndrome due to 11p15 microduplication 10.3 H19 IGF2
26 beckwith-wiedemann syndrome due to imprinting defect of 11p15 10.2 H19 IGF2
27 hereditary wilms' tumor 10.2 CDKN1C IGF2
28 gestational trophoblastic neoplasm 10.2 CDKN1C H19
29 hydatidiform mole, recurrent, 1 10.1 CDKN1C H19
30 trophoblastic neoplasm 10.0 CDKN1C H19
31 liver cirrhosis 10.0
32 kidney cancer 9.9 H19 MTOR
33 fetal macrosomia 9.9 H19 IGF2
34 endometriosis 9.9
35 peritonitis 9.9
36 hemihyperplasia, isolated 9.9 CDKN1C H19 IGF2
37 inguinal hernia 9.8
38 portal hypertension 9.8
39 intestinal perforation 9.8
40 kidney disease 9.8
41 actinomycosis 9.8
42 polycystic kidney disease 9.8
43 urachal cyst 9.8
44 wilms tumor 5 9.8 CDKN1C H19 IGF2
45 silver-russell syndrome 9.8 CDKN1C H19 IGF2
46 hepatoblastoma 9.8 CDKN1C H19 IGF2
47 adrenocortical carcinoma, hereditary 9.8 CDKN1C H19 IGF2
48 omphalocele 9.7 CDKN1C PLOD1
49 beckwith-wiedemann syndrome 9.7 CDKN1C H19 IGF2
50 hernia, hiatus 9.7

Graphical network of the top 20 diseases related to Umbilical Hernia:



Diseases related to Umbilical Hernia

Symptoms & Phenotypes for Umbilical Hernia

GenomeRNAi Phenotypes related to Umbilical Hernia according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.6 MTOR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.6 ELMO2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.6 ELMO2 MTOR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.6 ELMO2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.6 ELMO2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.6 ELMO2 MTOR CDKN1C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.6 CDKN1C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 MTOR
9 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.6 CDKN1C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.6 CDKN1C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.6 CDKN1C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.6 CDKN1C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.6 MTOR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.6 ELMO2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.6 MTOR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.6 ELMO2

MGI Mouse Phenotypes related to Umbilical Hernia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 DNMT3A IGF2 MEGF8 MTOR PLOD1

Drugs & Therapeutics for Umbilical Hernia

Drugs for Umbilical Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 3,Not Applicable 15687-27-1 3672
2
Bupivacaine Approved, Investigational Phase 2, Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
3 Liver Extracts Phase 3
4 Analgesics Phase 3,Not Applicable
5 Analgesics, Non-Narcotic Phase 3,Not Applicable
6 Anti-Inflammatory Agents Phase 3,Not Applicable
7 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Not Applicable
8 Antirheumatic Agents Phase 3,Not Applicable
9 Central Nervous System Depressants Phase 3,Phase 2,Not Applicable
10 Cyclooxygenase Inhibitors Phase 3,Not Applicable
11 Narcotics Phase 3
12 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
13 Anesthetics Phase 2, Phase 3,Not Applicable
14 Anesthetics, Local Phase 2, Phase 3,Not Applicable
15
Ropivacaine Approved Not Applicable 84057-95-4 71273 175805
16
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
17
Acetaminophen Approved Not Applicable 103-90-2 1983
18
Selenium Approved, Investigational, Vet_approved Not Applicable 7782-49-2
19
Menthol Approved Not Applicable 2216-51-5 16666
20
Methionine Approved, Nutraceutical Not Applicable 63-68-3 6137
21 Coagulants Not Applicable
22 Fibrin Tissue Adhesive Not Applicable
23 Hemostatics Not Applicable
24 Antipyretics Not Applicable
25 Antioxidants Not Applicable
26 Micronutrients Not Applicable
27 Protective Agents Not Applicable
28 Trace Elements Not Applicable
29 Anesthetics, General Not Applicable

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Conservative Treatment Versus Elective Repair of Umbilical Hernia in Patients With Ascites and Liver Cirrhosis Unknown status NCT01421550 Phase 3
2 Does Preoperative Caldolor Decrease the Requirement for Postoperative Narcotics Unknown status NCT01297829 Phase 3 Intravenous Ibuprofen
3 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3
4 North American Study for the Treatment of Refractory Ascites (NASTRA) Completed NCT00006166 Phase 3
5 Comparative Study Matching Intraperitoneal Onlay Mesh (IPOM) and Sublay Mesh to Treat Umbilical Hernia Recruiting NCT01201564 Phase 3
6 Caudal Versus Rectus Sheath Study Terminated NCT01394523 Phase 2, Phase 3 Bupivacaine
7 Does a Transabdominal Plane Block Decrease Patient Pain After Ventral Hernia Repair? Completed NCT02007096 Phase 2 Transabdominal Plane Block;Non Transabdominal Plane Block
8 Laparoscopic or Conventional Mesh Repair of Incisional and Umbilical Hernia Unknown status NCT00970515 Not Applicable
9 The Flemish Umbilical Nitinol Mesh Trial, a Multicenter Trial Unknown status NCT01543789 Not Applicable
10 The Impact of Medical Clowning on Pain and Stress Level in Pediatric Patients Undergoing Hernia Repair Surgery LAUGH Study. Unknown status NCT01622218 Not Applicable
11 Case-control Study of Mesh-infection After a Size Tailored Hernia Repair With C-Qur V-Patch Unknown status NCT01761708
12 Primary and Secondary Ventral Hernia Repair Using Long-term Resorbable Versus Non-resorbable Large Pore Synthetic Mesh. Unknown status NCT01622725 Not Applicable
13 Effect of Reoperation for Recurrence After Open Umbilical Hernia Repair Completed NCT01607801
14 Analgesic Efficacy After Umbilical Hernia Repair in Children Completed NCT00578136 Not Applicable Bupivacaine
15 Mesh Versus Suture Repair for Umbilical Hernias Completed NCT00789230 Not Applicable
16 Percutaneous Rectus Sheath Block Versus Intra-operative Rectus Sheath Block for Pediatric Umbilical Hernia Repair Completed NCT02341144 Not Applicable Ropivacaine
17 Ultrasound-guided Rectus Sheath Block for Post-operative Pain Control Following Umbilical Hernia Repair Completed NCT00836134 Not Applicable
18 Risk Factors for Poor Outcome After Epigastric and Umbilical Hernia Repair Completed NCT01665859
19 Postoperative Pain After Pediatric Umbilical Hernia Repair Completed NCT01015053 Not Applicable
20 Chronic Complaints After Small Umbilical Hernia Repair Completed NCT01741740
21 Self-Expanding Multi-Layered Partially Resorbable Lightweight Polypropylene Mesh Device (Proceed Ventral Patch® Or Pvp®) For The Treatment of Small and Medium Umbilical Ventral Hernias Completed NCT01307696
22 The Effect of Sutures Versus Mesh in Umbilical Hernia Repair Completed NCT01635868
23 Mesh Fixation With Intraperitoneal Tisseel Completed NCT00842842 Not Applicable
24 Prospective Evaluation of the Proceed Ventral Patch With and Without Laparoscopic Evaluation Completed NCT01183325 Not Applicable
25 Risk of Umbilical Trocar-site Hernia After SILC Cholecystectomy Versus Conventional Cholecystectomy Completed NCT01740973
26 Watchful Waiting of Incisional Hernias Completed NCT00351455 Not Applicable
27 Quality of Life After Laparoscopic Inguinal- Incisional and Umbilical Herniotomy. Completed NCT01289093
28 A Trial Comparing Combination Therapy of Acetaminophen Plus Ibuprofen Versus Tylenol #3 for the Treatment of Pain After Outpatient Surgery Completed NCT00245375 Not Applicable Tylenol #3;Combination Tylenol and Ibuprofen
29 No Need for Neuromuscular Blockade in Daycase Laparoscopic Surgery Completed NCT02782832
30 Selenium Supplementation in Pregnancy Completed NCT01465867 Not Applicable
31 A Retrospective Study With Prospective Follow-Up of Laparoscopic Ventral Hernia Repair Utilizing the Bard Sepramesh IP Composite Completed NCT01305473
32 Abdominal Wall Block Study Recruiting NCT03074240 Not Applicable
33 Natural Orifice Translumenal Endoscopic Surgery (NOTES): Laparoscopic Assisted Transvaginal Ventral Hernia Repair Recruiting NCT01398215
34 Open Preperitoneal Mesh Versus Retromuscular Mesh Versus Suture Repair for Abdominal Wall Hernias Recruiting NCT03255239 Not Applicable
35 Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy Recruiting NCT02494336 Not Applicable Ropivacaine
36 Prevalence of Sarcopenia and Undernutrition in Patients With Cirrhosis and Abdominal Hernia Recruiting NCT03458845
37 Visible vs. Non-Visible Mesh in Underlay Positon After Repair of Umbilical Hernias Active, not recruiting NCT03200405 Not Applicable
38 Robotic Utility for Surgical Treatment of Umbilical Hernias Active, not recruiting NCT02975414
39 A Cross-specialty Collaboration Platform for Mucopolysaccharidosis Confirmative Diagnosis Not yet recruiting NCT03017677
40 Minimally Invasive Closure of Umbilical Hernias Terminated NCT00706329 Not Applicable
41 Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High-Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric ENT Surgery (The HATT Project) Terminated NCT02095015
42 Prospective Study Of A Size Tailored Approach To Repair Umbilical And Epigastric Primary Ventral Hernias Terminated NCT01639118

Search NIH Clinical Center for Umbilical Hernia

Cochrane evidence based reviews: hernia, umbilical

Genetic Tests for Umbilical Hernia

Genetic tests related to Umbilical Hernia:

# Genetic test Affiliating Genes
1 Umbilical Hernia 29

Anatomical Context for Umbilical Hernia

MalaCards organs/tissues related to Umbilical Hernia:

41
Small Intestine, Liver, Kidney, Appendix

Publications for Umbilical Hernia

Articles related to Umbilical Hernia:

(show top 50) (show all 107)
# Title Authors Year
1
Commentary on: Concomitant Abdominoplasty and Laparoscopic Umbilical Hernia Repair. ( 29924292 )
2018
2
Mesh migration into an inguinal hernia sac following a laparoscopic umbilical hernia repair. ( 29605843 )
2018
3
Variceal hemorrhage with white nipple sign associated with strangulated umbilical hernia in a patient with cirrhosis. ( 29425783 )
2018
4
Umbilical Hernia with Evisceration. Two Cases and a Review of the Literature. ( 29793813 )
2018
5
Concomitant Abdominoplasty and Laparoscopic Umbilical Hernia Repair. ( 29897393 )
2018
6
Mesh versus suture repair of umbilical hernia in adults: a randomised, double-blind, controlled, multicentre trial. ( 29459021 )
2018
7
Concurrent Umbilical Hernia Repair at the Time of Liver Transplantation: A Six-Year Experience from a Single Institution. ( 29531643 )
2018
8
Safety and effectiveness of umbilical hernia repair in patients with cirrhosis. ( 29589135 )
2018
9
Genome-wide association study reveals a QTL and strong candidate genes for umbilical hernia in pigs on SSC14. ( 29843603 )
2018
10
Importance of mesh overlap on hernia recurrence after open umbilical hernia repair with bilayer prosthesis. ( 29429547 )
2018
11
Umbilical Hernia Repair: Overview of Approaches and Review of Literature. ( 29754622 )
2018
12
Spontaneous Endometriosis Within a Primary Umbilical Hernia. ( 29164008 )
2017
13
Laparoscopic transabdominal preperitoneal approach for umbilical hernia with rectus diastasis. ( 28727317 )
2017
14
Incarceration of a pedunculated uterine fibroid in an umbilical hernia. ( 28534020 )
2017
15
Simultaneous Abdominoplasty and Umbilical Hernia Repair via Laparoscopy: a Preliminary Report. ( 28704183 )
2017
16
Laparoscopic versus Open Repair of Para-Umbilical Hernia- A Prospective Comparative Study of Short Term Outcomes. ( 28969195 )
2017
17
Percutaneous ultrasound-guided vs. intraoperative rectus sheath block for pediatric umbilical hernia repair: A randomized clinical trial. ( 28377023 )
2017
18
Rupture of Umbilical Hernia with Evisceration in a Newborn - A Case Report. ( 28920027 )
2017
19
A new approach to umbilical hernia repair: the Circular suture technique for defects less than 2 cm. ( 28892467 )
2017
20
Umbilical appearance and patient/parent satisfaction over 5years of follow-up after umbilical hernia repair in children. ( 28629819 )
2017
21
Mesh Versus Patch Repair for Epigastric and Umbilical Hernia (MORPHEUS Trial); One-Year Results of a Randomized Controlled Trial. ( 29026977 )
2017
22
Unusual clinical umbilical hernia: pitfall. ( 28381548 )
2017
23
Spontaneous evisceration of umbilical hernia in a patient with congenital nephrotic syndrome. ( 28507377 )
2017
24
The Effect of Rectus Sheath Block as a Supplement of General Anesthesia on Postoperative Analgesia in Adult Patient Undergoing Umbilical Hernia Repair. ( 29668467 )
2017
25
Surprising Twist in the Plot - Sister Mary Joseph's Nodule of Pancreatic Cancer Mimicking Wound Infection after Umbilical Hernia Repair. ( 28589449 )
2017
26
Postoperative Pain After Laparoscopic Repair of Primary Umbilical Hernia: Titanium Tacks Versus Absorbable Tacks: A Prospective Comparative Cohort Analysis of 80 Patients With a Long-term Follow-up. ( 28915205 )
2017
27
Factors Associated With Long-term Outcomes of Umbilical Hernia Repair. ( 28122076 )
2017
28
Complexity of the "Simple" Umbilical Hernia Repair. ( 28122080 )
2017
29
The Evaluation of the Therapeutic Outcomes of Umbilical Hernia. ( 28833971 )
2017
30
Umbilical Hernia. ( 28586889 )
2017
31
The feasibility of local anesthesia for the surgical treatment of umbilical hernia: a systematic review of the literature. ( 28108822 )
2017
32
Simultaneous Umbilical Hernia Repair with Transumbilical Ventriculoperitoneal Shunt Placement. ( 28208152 )
2017
33
Long-term follow-up results of umbilical hernia repair. ( 29362649 )
2017
34
Umbilical hernia repair in pregnant patients: review of the American College of Surgeons National Surgical Quality Improvement Program. ( 28735364 )
2017
35
Flood Syndrome: Spontaneous Umbilical Hernia Rupture Leaking Ascitic Fluid-A Case Report. ( 28678688 )
2017
36
A genome-wide association study of copy number variations with umbilical hernia in swine. ( 27028052 )
2016
37
Intestinal blood flow assessment by indocyanine green fluorescence imaging in a patient with the incarcerated umbilical hernia: Report of a case. ( 27257484 )
2016
38
A complication to remember: stitch sinus following laparoscopic umbilical hernia repair. ( 27572679 )
2016
39
Mucinous cystadenoma of the appendix presenting as an umbilical hernia: A case report. ( 27313766 )
2016
40
Spontaneous endometriosis associated with an umbilical hernia: A case report and review of the literature. ( 27898348 )
2016
41
Elective Surgery of Umbilical Hernia as a First Clinical Manifestation of a Gastrointestinal Stromal Tumor (Gist) - Case Report. ( 27648625 )
2016
42
Umbilical hernia masking primary umbilical endometriosis - a case report. ( 27833977 )
2016
43
Surgical outcome of mesh and suture repair in primary umbilical hernia: postoperative complications and recurrence. ( 26879081 )
2016
44
Intestinal Perforation in Obstructed Umbilical Hernia due to Wedged Plum Seed. ( 27398326 )
2016
45
Severe Hydronephrosis and Perinephric Urinoma with Rupture of Renal Fornix Secondary to Postoperative Urinary Retention following Laparoscopic Umbilical Hernia Repair. ( 27555977 )
2016
46
The Hernia-Neck-Ratio (HNR), a Novel Predictive Factor for Complications of Umbilical Hernia. ( 27194561 )
2016
47
Umbilical hernia following gastroschisis closure: a common event? ( 27344584 )
2016
48
Association of umbilical hernia with volume of ascites in liver cirrhosis: A retrospective observational study. ( 27792277 )
2016
49
Proposed technique for open repair of a small umbilical hernia and rectus divarication with self-gripping mesh. ( 26886012 )
2016
50
A multi-institutional, propensity-score-matched comparison of post-operative outcomes between general anesthesia and monitored anesthesia care with intravenous sedation in umbilical hernia repair. ( 26860730 )
2016

Variations for Umbilical Hernia

ClinVar genetic disease variations for Umbilical Hernia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 complex Pathogenic
2 46;XY;inv(6)(p22q13)dn inversion Pathogenic
3 PLOD1 NM_000302.3(PLOD1): c.1562G> A (p.Trp521Ter) single nucleotide variant Pathogenic rs1057518879 GRCh37 Chromosome 1, 12025628: 12025628
4 PLOD1 NM_000302.3(PLOD1): c.1562G> A (p.Trp521Ter) single nucleotide variant Pathogenic rs1057518879 GRCh38 Chromosome 1, 11965571: 11965571
5 PLOD1 GRCh37/hg19 1p36.22(chr1: 12019879-12028775) copy number gain Pathogenic GRCh37 Chromosome 1, 12019879: 12028775
6 PLOD1 GRCh37/hg19 1p36.22(chr1: 12019879-12028775) copy number gain Pathogenic GRCh37 Chromosome 1, 12019879: 12028775
7 PLOD1 GRCh37/hg19 1p36.22(chr1: 12019879-12028775) copy number gain Pathogenic GRCh37 Chromosome 1, 12019879: 12028775
8 subset of 29 genes:TBX1 GRCh37/hg19 22q11.21(chr22: 18894835-20311763) copy number loss Pathogenic GRCh37 Chromosome 22, 18894835: 20311763

Expression for Umbilical Hernia

Search GEO for disease gene expression data for Umbilical Hernia.

Pathways for Umbilical Hernia

Pathways related to Umbilical Hernia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 IGF2 MTOR
2
Show member pathways
10.04 IGF2 MTOR

GO Terms for Umbilical Hernia

Biological processes related to Umbilical Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 9.37 DNMT3A IGF2
2 regulation of gene expression GO:0010468 9.33 DNMT3A IGF2 MEGF8
3 cellular response to amino acid stimulus GO:0071230 9.32 DNMT3A MTOR
4 positive regulation of cell death GO:0010942 9.26 DNMT3A MTOR
5 response to cocaine GO:0042220 8.96 DNMT3A MTOR
6 regulation of gene expression by genetic imprinting GO:0006349 8.62 DNMT3A IGF2

Sources for Umbilical Hernia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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