MCID: UMB002
MIFTS: 47

Umbilical Hernia

Categories: Gastrointestinal diseases
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Aliases & Classifications for Umbilical Hernia

Summaries for Umbilical Hernia

Disease Ontology: 11 A intestinal disease characterized by the protrusion by part of the intestine though an opening in the abdominal muscles.

MalaCards based summary: Umbilical Hernia, also known as hernia, umbilical, is related to hurler-scheie syndrome and beckwith-wiedemann syndrome. An important gene associated with Umbilical Hernia is PLOD1 (Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 1), and among its related pathways/superpathways are Disease and Endochondral ossification. The drugs Bupivacaine and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and lung, and related phenotypes are nervous system and growth/size/body region

Wikipedia: 75 An umbilical hernia is a health condition where the abdominal wall behind the navel is damaged. It may... more...

Related Diseases for Umbilical Hernia

Diseases related to Umbilical Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
# Related Disease Score Top Affiliating Genes
1 hurler-scheie syndrome 31.9 IDUA ARSB
2 beckwith-wiedemann syndrome 31.1 PLAGL1 KCNQ1OT1 IGF2 HYMAI H19 DYNC1I2
3 inguinal hernia 31.0 IDUA ARSB ACTL6A
4 adult syndrome 30.1 PLAGL1 IGF2 DNMT3A
5 hemihyperplasia, isolated 30.0 KCNQ1OT1 IGF2 H19 CDKN1C
6 omphalocele 29.9 SPECC1L PLOD1 PITX2 KCNQ1OT1 IGF2 DYNC1I2
7 smith-kingsmore syndrome 11.6
8 weaver syndrome 11.3
9 3mc syndrome 11.3
10 gastroschisis 11.3
11 enterocele 11.3
12 shprintzen-goldberg craniosynostosis syndrome 11.2
13 carpenter syndrome 1 11.2
14 scarf syndrome 11.2
15 simpson-golabi-behmel syndrome, type 1 11.2
16 chromosome 6q11-q14 deletion syndrome 11.2
17 carpenter syndrome 2 11.2
18 cohen-gibson syndrome 11.2
19 scheie syndrome 11.1
20 mucopolysaccharidosis, type ii 11.1
21 spondylocostal dysostosis 5 11.1
22 chromosome 9p deletion syndrome 11.1
23 aural atresia, multiple congenital anomalies, and mental retardation 11.1
24 fraser syndrome 1 11.1
25 ehlers-danlos syndrome, dermatosparaxis type 11.1
26 3mc syndrome 3 11.1
27 manitoba oculotrichoanal syndrome 11.1
28 mucolipidosis ii alpha/beta 11.1
29 mucopolysaccharidosis, type vi 11.1
30 mucopolysaccharidosis, type vii 11.1
31 3mc syndrome 1 11.1
32 3mc syndrome 2 11.1
33 martin-probst syndrome 11.1
34 aarskog-scott syndrome 11.1
35 achondrogenesis, type ib 11.1
36 nicolaides-baraitser syndrome 11.1
37 metaphyseal undermodeling, spondylar dysplasia, and overgrowth 11.1
38 fontaine progeroid syndrome 11.1
39 tatton-brown-rahman syndrome 11.1
40 hyperekplexia 4 11.1
41 hennekam syndrome 11.1
42 achondrogenesis 11.1
43 mucopolysaccharidosis iii 11.1
44 mucopolysaccharidosis iv 11.1
45 cutis laxa 11.1
46 diabetes mellitus, 6q24-related transient neonatal 11.1
47 peripheral resistance to thyroid hormones 11.1
48 overgrowth syndrome with 2q37 translocation 11.1
49 distal trisomy 6q 11.1
50 traf7-associated heart defect-digital anomalies-facial dysmorphism-motor and speech delay syndrome 11.1

Graphical network of the top 20 diseases related to Umbilical Hernia:



Diseases related to Umbilical Hernia

Symptoms & Phenotypes for Umbilical Hernia

MGI Mouse Phenotypes related to Umbilical Hernia:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.35 ARSB CDKN1C CHST14 DNMT3A GLI3 IDUA
2 growth/size/body region MP:0005378 10.35 ABCC8 ADAMTS2 ARSB CDKN1C CHST14 DNMT3A
3 cellular MP:0005384 10.28 ACTL6A ADAMTS2 ARSB CDKN1C CHST14 DNMT3A
4 muscle MP:0005369 10.21 ADAMTS2 ARSB CDKN1C DNMT3A IDUA IGF2
5 renal/urinary system MP:0005367 10.18 ARSB CDKN1C CHST14 GLI3 IDUA IGF2
6 embryo MP:0005380 10.16 CDKN1C DNMT3A GLI3 IGF2 KCNQ1OT1 MEGF8
7 limbs/digits/tail MP:0005371 10.15 ARSB CDKN1C CHST14 GLI3 IDUA IGF2
8 cardiovascular system MP:0005385 10.15 ABCC8 ARSB CDKN1C CHST14 GLI3 IDUA
9 craniofacial MP:0005382 10.13 ADAMTS2 ARSB CDKN1C CHST14 GLI3 IDUA
10 behavior/neurological MP:0005386 10.1 ACTL6A ARSB CDKN1C CHST14 DNMT3A DYNC1I2
11 no phenotypic analysis MP:0003012 10.09 ABCC8 GLI3 IGF2 MTOR PITX2 PLAGL1
12 respiratory system MP:0005388 9.96 ADAMTS2 ARSB CDKN1C GLI3 IGF2 KCNQ1OT1
13 skeleton MP:0005390 9.93 ADAMTS2 ARSB CDKN1C CHST14 DNMT3A GLI3
14 vision/eye MP:0005391 9.61 ADAMTS2 ARSB CDKN1C GLI3 IDUA IGF2
15 mortality/aging MP:0010768 9.47 ACTL6A CDKN1C CHST14 DNMT3A GLI3 IDUA

Drugs & Therapeutics for Umbilical Hernia

Drugs for Umbilical Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2
Ibuprofen Approved Phase 3 15687-27-1 3672
3 Liver Extracts Phase 3
4 Cyclooxygenase Inhibitors Phase 3
5 Antirheumatic Agents Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Analgesics, Non-Narcotic Phase 3
8 Anti-Inflammatory Agents Phase 3
9 Narcotics Phase 3
10
Sodium oxybate Approved 502-85-2 23663870
11
Acetaminophen Approved 103-90-2 1983
12
Morphine Approved, Investigational 57-27-2 5288826
13
Ropivacaine Approved 84057-95-4 71273 175805
14
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
15
Prilocaine Approved 721-50-6 4906
16
Sufentanil Approved, Investigational 56030-54-7 41693
17
Chloroprocaine Approved, Investigational 133-16-4 8612
18
Iron Approved 7439-89-6 29936
19 Fluorides
20 Anesthetics, General
21 Analgesics
22 Antipyretics
23 Ferrosoferric Oxide
24 Fibrin Tissue Adhesive
25 Dsuvia
26 Anesthetics, Local
27 Anesthetics
28 Hemostatics
29 Chrysarobin
30 Antibiotics, Antitubercular
31 Anti-Bacterial Agents
32 diuretics

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 U/s Guided Oblique Subcostal Transversus Abdominis Plane Block Versus Erector Spinae Plane Block as Pre-emptive Analgesia for Open Umbilical Hernia Repair; Randomized, Double-blinded Controlled Trial Completed NCT04941170 Phase 4 Bupivacain;Bupivacaine
2 Prospective Randomized Multicenter Trial Comparing Laparoscopic (IPOM) vs. Sublay Mesh Plasty for Umbilical Hernia in Adults Terminated NCT01201564 Phase 4
3 Conservative Treatment Versus Elective Repair of the Umbilical Hernia in Patients With Ascites and Liver Cirrhosis, a Randomized Controlled Trial Unknown status NCT01421550 Phase 3
4 Does Preoperative Caldolor Decrease the Requirement for Postoperative Narcotics in Patients Undergoing Laparoscopic or Open Inguinal and/or Umbilical Hernia Repair? A Randomized, Double-Blind, Prospective Trial Unknown status NCT01297829 Phase 3 Intravenous Ibuprofen
5 A Prospective, Double-blinded, Randomized Comparison of Caudal Analgesia Versus Ultrasound Guided Rectus Sheath Blocks for Umbilical Herniorrhaphy in the Pediatric Population Terminated NCT01394523 Phase 2, Phase 3 Bupivacaine
6 Transabdominal Plane (TAP) Blocks in Ventral Hernia Repair Completed NCT02007096 Phase 2 Transabdominal Plane Block;Non Transabdominal Plane Block
7 The Flemish Umbilical Nitinol Mesh Trial, a Multicenter Randomized Controlled Trial. Unknown status NCT01543789
8 Anxiety and Chronic Postsurgical Pain Following Ambulatory Surgery in Children Unknown status NCT04206956
9 Natural Orifice Translumenal Endoscopic Surgery (NOTES): Laparoscopic Assisted Transvaginal Ventral Hernia Repair Unknown status NCT01398215
10 Local Repair of Umbilical Hernia in Cirrhotic Patient Using Intraperitoneal Onlay Mesh Technique Unknown status NCT04088253
11 Case-control Study of Mesh-infection After a Size Tailored Hernia Repair With C-Qur V-Patch Unknown status NCT01761708
12 Randomized Clinical Trial Comparing Open Preperitoneal Mesh, Retromuscular Mesh and Suture Repair for Abdominal Wall Hernias Less Than 3 cm Diameter Unknown status NCT03255239
13 Prospective Randomized Trial to Study the Effectiveness of an Intraperitoneal Mesh With an Overlap of 3cm Versus a Rives-Stoppa Repair With an Overlap of 6cm With Patients With a Hernia Umbilicalis Unknown status NCT00323141
14 Functional Magnetic Resonance Imaging - Blood Oxygenation Level Dependent (MRI-BOLD) of the Feta Lung in Congenital Diaphragmatic and Parietal Malformations Unknown status NCT04186039
15 Utility of a Supraaponeurotic Mesh as Prophylaxis of the Midline Eventration After an Oncological Colorrectal Resection Unknown status NCT03520465
16 Mesh Versus Suture Repair for Umbilical Hernias: a Double Blinded, Randomised Controlled Clinical Trial Completed NCT00789230
17 A Prospective and Randomized Comparison of Ultrasound-guided Transversus Abdominis Plane Versus Rectus Sheath Blocks as a Primary Anesthetic for Abdominal Wall Surgery in Adults. Completed NCT03074240
18 A Randomized Controlled Trial Comparing Combination Therapy of Acetaminophen Plus Ibuprofen Versus Tylenol #3 for the Treatment of Pain After Outpatient Surgery Completed NCT00245375 Tylenol #3;Combination Tylenol and Ibuprofen
19 Watchful Waiting of Incisional Hernias: A Prospective Trial Completed NCT00351455
20 A Randomized-Double Blinded Trial Comparing the Analgesic Efficacy and Side Effects of Rectus Sheath Block vs. Infiltration of Surgical Site for Post Operative Pain Control After Umbilical Hernia Repair Surgery Completed NCT00578136 Bupivacaine
21 Multicenter Prospective Clinical Registry To Evaluate The Safety And Efficacy Of A Self-Expanding Multi-Layered Partially Resorbable Absorbable Lightweight Polypropylene Mesh Device (Proceed Ventral Patch® Or Pvp®) For The Treatment Of Small And Medium Umbilical Ventral Hernias Completed NCT01307696
22 No Need for Neuromuscular Blockade in Day Case Standardised Laparoscopic Surgery. A Consecutive Retrospective Study Completed NCT02782832
23 The Impact of Medical Clowning on Pain and Stress Level in Pediatric Patients Undergoing Hernia Repair Surgery LAUGH Study Completed NCT01622218
24 Effect of Reoperation for Recurrence After Open Surgery for Small Umbilical Hernia With Sutured Mesh or Plastic Surgery. A National Hernia Database Study. Completed NCT01607801
25 Morphological Imaging of Meshes in Underlay Position After Treatment of Primary Umbilical Hernias: a Randomised Controlled Trial Completed NCT03200405
26 Nationwide Prospective Study of Surgical Risk Factors for Poor Outcome After Epigastric and Umbilical Hernia Repair Completed NCT01665859
27 Prospective Observational Cohort Study of Robot-assisted Laparoscopic Hernia Umbilical Hernia Repair (rTARUP) Completed NCT02975414
28 Ultrasound-guided Rectus Sheath Block for Post-operative Pain Control Following Umbilical Hernia Repair Completed NCT00836134
29 High Incidence of Chronic Complaints and Recurrence 5 Years After Simple Sutured Umbilical Hernia Repair Completed NCT01741740
30 Postoperative Pain After Pediatric Umbilical Hernia Repair: a Randomized Clinical Trial of Ultrasound-guided Bilateral Rectus Sheath Blocks Versus Local Anesthetic Infiltration Completed NCT01015053
31 A Prospective, Controlled, Randomized, Patient and Evaluator Blinded Study to Evaluate Pain and Recovery in Patients Undergoing Laparoscopic Umbilical Hernia Repair by Fixing the Mesh With Tisseel Versus Tackers Completed NCT00842842
32 Percutaneous Rectus Sheath Block Versus Intra-operative Rectus Sheath Block for Pediatric Umbilical Hernia Repair: A Prospective, Randomized Study Completed NCT02341144 Ropivacaine
33 Multicentric Evaluation of the Proceed Ventral Patch for Umbilical and Small Primary Ventral Hernias Less Than 3cm Diameter With One Year Follow-up Completed NCT01183325
34 Intrathecal 60mg Prilocaine, Hyperbaric 40mg 9-chloroprocaine and 10.5mg Bupivacaine Each With Added Sufentanil (2µg) for Elective Ambulatory Umbilical and Unilateral Inguinal Herniorrhaphy Completed NCT02813382 Bupivacaine;Prilocaine;Chloroprocaine
35 Health Related Quality of Life of Patients With Abdominal Wall Defects Completed NCT03960320
36 Quality of Life After Laparoscopic Inguinal- Incisional- and Umbilical Herniotomy. Completed NCT01289093
37 Laparoscopic Primary Umbilical Hernia Repair With Routine Defect Closure Using Su2ura Approximation Device Recruiting NCT04393532
38 Randomized Double-blind Controlled Multicenter Trial Comparing Suture and Mesh Repair in Small Umbilical Hernias in Adults Recruiting NCT04231071
39 Erector Spinae Plane Block Versus Oblique Subcostal Transverses Abdominis Plane Block for Controlling Postoperative Pain After Umbilical Hernia Repair Recruiting NCT05286125
40 Omphaloceles and Associated Malformations in Preterm and Term Newborns Recruiting NCT04126863
41 Registry Based, Randomized Controlled Trial Comparing eTEP and Laparoscopic Intraperitoneal Onlay Mesh (IPOM) for Ventral Hernia Repair Active, not recruiting NCT04150796
42 Elective Umbilical Hernia Repair in Patients With Cirrhosis - a Prospective, Controlled Interventional Study Not yet recruiting NCT04687579
43 Prospective Cohort Study on Mesh Shrinkage Measured With MRI After Robot Assisted Laparoscopic Preperitoneal Mesh Repair Using an Iron Oxide Loaded PVDF Mesh Not yet recruiting NCT05576753
44 Paediatric Treatment of Diaphragmatic Eventrations in France: Management Strategies and Long-term Results : an Observational Study. Not yet recruiting NCT04862494
45 A Prospective, Multicenter, Randomized Trial Comparing Laparoscopy VS Conventional Mesh Repair of Incisional and Umbilical Hernia Terminated NCT00970515
46 Study of Minimally Invasive Closure of Umbilical Hernias Terminated NCT00706329
47 Prospective Observational Cohort Study Of A Size Tailored Approach To Repair Umbilical And Epigastric Primary Ventral Hernias Terminated NCT01639118
48 Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric Ear, Nose and Throat (ENT) Surgery (Adenoidectomy and/or Tonsillectomy and/or Tympanostomy) (The HATT Project) Terminated NCT02095015

Search NIH Clinical Center for Umbilical Hernia

Cochrane evidence based reviews: hernia, umbilical

Genetic Tests for Umbilical Hernia

Genetic tests related to Umbilical Hernia:

# Genetic test Affiliating Genes
1 Umbilical Hernia 28

Anatomical Context for Umbilical Hernia

Organs/tissues related to Umbilical Hernia:

MalaCards : Small Intestine, Liver, Lung, Uterus, Appendix, Skin, Colon

Publications for Umbilical Hernia

Articles related to Umbilical Hernia:

(show top 50) (show all 1787)
# Title Authors PMID Year
1
Gangrene of the Colon Ascendens, Colon Transversum, and Lienal Flexure in a Massive Strangulated Umbilical Hernia. 62
36225246 2022
2
[Analysis of clinical features and genetic variants in a child with autosomal recessive cutis laxa due to variants of ATP6V0A2 gene]. 62
36184099 2022
3
Characterization of a Novel Frameshift Mutation Within the TRPS1 Gene Causing Trichorhinophalangeal Syndrome Type 1 in a Kindred Cypriot Family. 62
36093893 2022
4
Acute abdomen with a parasitic smooth muscle tumor of uncertain malignant potential (STUMP) in pregnancy; a unique case report. 62
36265425 2022
5
Recognition and repair of an incidental umbilical hernia repair during abdominoplasty. 62
36268346 2022
6
Expanding the Phenotypic Spectrum of APMR4 Syndrome Caused by a Novel Variant in LSS Gene and Review of Literature. 62
36251212 2022
7
2q37 deletion syndrome in a Colombian patient with macrocephaly: a case report. 62
36192675 2022
8
Umbilical access in laparoscopic surgery in infants less than 3 months: A single institution retrospective review. 62
34872728 2022
9
Umbilical hernia: could it be the 'canary in the coal mine' for a more significant abdominal wall problem? 62
36036361 2022
10
Risk factors for decompensation and death following umbilical hernia repair in patients with end-stage liver disease. 62
36062496 2022
11
Persistent low rates of same-day umbilical hernia repair in Australia over the past 20 years: is there a need to change? 62
35437895 2022
12
Incidental discovery of a giant ovarian cystadenoma. 62
36268316 2022
13
Zheng's anchor suturing technique for safe and cosmetic umbilical incision in transumbilical laparoendoscopic single-site surgeries. 62
36242640 2022
14
Frequency of Potentially Avoidable Surgical Referrals for Asymptomatic Umbilical Hernias in Children. 62
35525211 2022
15
Hernia recurrence after primary repair of small umbilical hernia defects. 62
36182599 2022
16
Operative time tracking for umbilical hernia patients. 62
36068384 2022
17
Multicenter analysis of laparoscopic versus open umbilical hernia repair with mesh: outcomes and quality of life (QoL). 62
35059834 2022
18
Laparoscopic Umbilical Hernia repair in male patients with abdominal obesity. 62
36246693 2022
19
A Program to Reduce Post-Operative Opioid Prescribing at a Veteran's Affairs Hospital. 62
36143098 2022
20
Decreasing opioid prescribing at discharge while maintaining adequate pain management is sustainable. 62
36188337 2022
21
Comparison of rectus sheath block and local anesthetic for analgesia in pediatric umbilical hernia repair: A systematic review and meta-analysis. 62
36086758 2022
22
eTEP inferior access with tailored retromuscular dissection for small to mid-sized umbilical hernia repair with or without inguinal hernia: early experience. 62
35962875 2022
23
A Case of Primary Endometriosis Associated With an Umbilical Hernia. 62
36072205 2022
24
Chances of Mortality Are 3.5-Times Greater in Elderly Patients with Umbilical Hernia Than in Adult Patients: An Analysis of 21,242 Patients. 62
36012037 2022
25
A Prospective Observational Study of Ventral Hernia. 62
36158325 2022
26
Same-Day Surgery Clinic: A model for improving access to care at academic medical centers. 62
36075762 2022
27
Flood Syndrome. 62
36128184 2022
28
Tailored order set in the electronic health record decreases postoperative opioid prescriptions. 62
35430051 2022
29
Suture or Mesh Repair of the Smallest Umbilical Hernias: A Nationwide Database Study. 62
35306587 2022
30
Management of patients with the Intravascular Ventricular Assist System (iVAS) for non-cardiac surgery. 62
35799566 2022
31
Ultrasound-guided caudal blockade and sedation for paediatric surgery: a retrospective cohort study. 62
35460068 2022
32
Long-term reoperation rate following primary ventral hernia repair: a register-based study. 62
35802262 2022
33
The analgesic efficacy of transversus abdominis plane block vs. wound infiltration after inguinal and infra-umbilical hernia repairs: A systematic review and meta-analysis with trial sequential analysis. 62
35131973 2022
34
Queen Caroline's Umbilical Hernia. 62
35796058 2022
35
Prolonged Neonatal Jaundice with umbilical hernia: A cause not to be missed. 62
35168908 2022
36
Risk factors for adverse outcomes in emergency versus nonemergency open umbilical hernia repair and opportunities for elective repair in a national cohort of patients with cirrhosis. 62
35058058 2022
37
Intestinal evisceration and Staphylococcus aureus bacteremia due to ruptured umbilical hernia in a patient with liver cirrhosis: a case report and literature review. 62
35903616 2022
38
Peri-operative Morbidity of Nissen Sleeve Gastrectomy: Prospective Evaluation of a Cohort of 365 Patients, Beyond the Learning Curve. 62
35524904 2022
39
The opioid reduction task force: using the ACHQC Data Registry to combat an epidemic in hernia patients. 62
35039950 2022
40
Expanding the phenotype of ATP6AP1 deficiency. 62
35732497 2022
41
Novel Technique of Laparoscopic e-TEP (Extended View Totally Extraperitoneal Repair) for Umbilical Hernia at a Tertiary Care Centre of Eastern India: a Case Series. 62
36032608 2022
42
Umbilical hernia repair post umbilical cord graft closure of gastroschisis: A cohort study. 62
35580418 2022
43
Flood syndrome: a rare case of spontaneous rupture of umbilical hernia in a cirrhotic patient. 62
35712608 2022
44
Transcatheter arterial embolization for postoperative hemorrhage complicating surgical repair of incarcerated umbilical hernia subsequent to Denver peritoneovenous shunting: A case report. 62
35432676 2022
45
Testing meshes in a computer model of a laparoscopic ventral hernia repair. 62
34528129 2022
46
Comparative evaluation of different techniques for herniorrhaphy in calves. 62
35861963 2022
47
Gross and histopathological evaluation of umbilical outpouchings in pigs. 62
35344801 2022
48
A Novel Modification of Subcutaneous Onlay Endoscopic Repair of Midline Ventral Hernias With Diastasis Recti: An Indian Experience. 62
35859952 2022
49
Perforated jejunal diverticulum as an unsual cause of acute abdomen: A case report. 62
35658300 2022
50
Incidence and risk factors for umbilical incisional hernia after reduced port colorectal surgery (SIL + 1 additional port)-is an umbilical midline approach really a problem? 62
35066629 2022

Variations for Umbilical Hernia

ClinVar genetic disease variations for Umbilical Hernia:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 PLOD1 GRCh37/hg19 1p36.22(chr1:12019879-12028775) CN GAIN Pathogenic
523237 GRCh37: 1:12019879-12028775
GRCh38:
2 overlap with 29 genes GRCh37/hg19 22q11.21(chr22:18894835-20311763) CN LOSS Pathogenic
523273 GRCh37: 22:18894835-20311763
GRCh38:
3 PLOD1 NM_000302.4(PLOD1):c.1562G>A (p.Trp521Ter) SNV Pathogenic
374077 rs1057518879 GRCh37: 1:12025628-12025628
GRCh38: 1:11965571-11965571
4 ACTL6A NM_004301.5(ACTL6A):c.1129C>T (p.Arg377Trp) SNV Likely Pathogenic
549661 rs868064163 GRCh37: 3:179304340-179304340
GRCh38: 3:179586552-179586552
5 GLI3 NM_000168.6(GLI3):c.1622C>T (p.Thr541Met) SNV Likely Pathogenic
627565 rs1562667078 GRCh37: 7:42018223-42018223
GRCh38: 7:41978624-41978624

Expression for Umbilical Hernia

Search GEO for disease gene expression data for Umbilical Hernia.

Pathways for Umbilical Hernia

Pathways related to Umbilical Hernia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 MTOR IDUA DYNC1I2 DNMT3A CHST14 CDKN1C
2
Show member pathways
11.23 IGF2 GLI3 CDKN1C

GO Terms for Umbilical Hernia

Biological processes related to Umbilical Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 camera-type eye development GO:0043010 9.65 PITX2 GLI3 CDKN1C
2 response to pH GO:0009268 9.46 ARSB ABCC8
3 embryonic placenta morphogenesis GO:0060669 9.26 IGF2 CDKN1C
4 embryonic heart tube left/right pattern formation GO:0060971 8.92 PITX2 MEGF8

Sources for Umbilical Hernia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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