MCID: UMB002
MIFTS: 42

Umbilical Hernia

Categories: Gastrointestinal diseases

Aliases & Classifications for Umbilical Hernia

Summaries for Umbilical Hernia

Disease Ontology : 12 A intestinal disease characterized by the protrusion by part of the intestine though an opening in the abdominal muscles.

MalaCards based summary : Umbilical Hernia, also known as hernia, umbilical, is related to omphalocele and smith-kingsmore syndrome. An important gene associated with Umbilical Hernia is PLOD1 (Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 1). The drugs Ibuprofen and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, uterus and kidney, and related phenotype is muscle.

Wikipedia : 77 An umbilical hernia is a health condition where the abdominal wall behind the navel is damaged. It may... more...

Related Diseases for Umbilical Hernia

Diseases related to Umbilical Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 omphalocele 29.4 CDKN1C PLOD1
2 smith-kingsmore syndrome 12.1
3 shprintzen-goldberg craniosynostosis syndrome 11.5
4 carpenter syndrome 2 11.3
5 hypothyroidism, congenital, nongoitrous, 2 11.1
6 fraser syndrome 1 11.1
7 ehlers-danlos syndrome, dermatosparaxis type 11.1
8 gapo syndrome 11.1
9 3mc syndrome 3 11.1
10 3mc syndrome 1 11.1
11 3mc syndrome 2 11.1
12 weaver syndrome 11.1
13 mental retardation, x-linked, syndromic, martin-probst type 11.1
14 achondrogenesis, type ib 11.1
15 fontaine progeroid syndrome 11.1
16 chromosome 6q11-q14 deletion syndrome 11.1
17 tatton-brown-rahman syndrome 11.1
18 cohen-gibson syndrome 11.1
19 hyperekplexia 4 11.1
20 bamforth syndrome 11.1
21 central congenital hypothyroidism 11.1
22 peripheral resistance to thyroid hormones 11.1
23 progeroid syndrome petty type 11.1
24 simpson-golabi-behmel syndrome 11.1
25 liver cirrhosis 10.3
26 endometriosis 10.2
27 inguinal hernia 10.1
28 liver disease 10.1
29 adenocarcinoma 10.1
30 pancreas adenocarcinoma 10.0
31 appendicitis 10.0
32 hemihyperplasia, isolated 9.9 CDKN1C H19
33 alcoholic liver cirrhosis 9.9
34 polycystic kidney disease 9.9
35 portal hypertension 9.9
36 intestinal perforation 9.9
37 cystadenoma 9.9
38 cystic teratoma 9.9
39 ischemia 9.9
40 teratoma 9.9
41 kidney disease 9.9
42 actinomycosis 9.9
43 urachal cyst 9.9
44 gestational trophoblastic neoplasm 9.9 CDKN1C H19
45 trophoblastic neoplasm 9.9 CDKN1C H19
46 hydatidiform mole, recurrent, 1 9.8 CDKN1C H19
47 diaphragmatic hernia, congenital 9.8
48 hernia, hiatus 9.8
49 intussusception 9.8
50 meckel diverticulum 9.8

Graphical network of the top 20 diseases related to Umbilical Hernia:



Diseases related to Umbilical Hernia

Symptoms & Phenotypes for Umbilical Hernia

MGI Mouse Phenotypes related to Umbilical Hernia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 DNMT3A IDUA MEGF8 MTOR PLOD1

Drugs & Therapeutics for Umbilical Hernia

Drugs for Umbilical Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 3,Not Applicable 15687-27-1 3672
2
Bupivacaine Approved, Investigational Phase 2, Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
3 Liver Extracts Phase 3
4 Analgesics Phase 3,Not Applicable
5 Antirheumatic Agents Phase 3,Not Applicable
6 Analgesics, Non-Narcotic Phase 3,Not Applicable
7 Central Nervous System Depressants Phase 3,Phase 2,Not Applicable
8 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
9 Anti-Inflammatory Agents Phase 3,Not Applicable
10 Cyclooxygenase Inhibitors Phase 3,Not Applicable
11 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Not Applicable
12 Narcotics Phase 3
13 Anesthetics, Local Phase 2, Phase 3,Not Applicable
14 Anesthetics Phase 2, Phase 3,Not Applicable
15
Ropivacaine Approved Not Applicable 84057-95-4 71273 175805
16
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
17
Acetaminophen Approved Not Applicable 103-90-2 1983
18
Selenium Approved, Investigational, Vet_approved Not Applicable 7782-49-2
19
Prilocaine Approved 721-50-6 4906
20
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
21
Chloroprocaine Approved 133-16-4 8612
22
Sufentanil Approved, Investigational 56030-54-7 41693
23
Sodium oxybate Approved Not Applicable 502-85-2 5360545
24
Methionine Approved, Nutraceutical Not Applicable 63-68-3 6137
25 Fibrin Tissue Adhesive Not Applicable
26 Hemostatics Not Applicable
27 Coagulants Not Applicable
28 Anesthetics, General Not Applicable
29 Antipyretics Not Applicable
30 Micronutrients Not Applicable
31 Protective Agents Not Applicable
32 Trace Elements Not Applicable
33 Nutrients Not Applicable
34 Antioxidants Not Applicable
35 Analgesics, Opioid
36 Anesthetics, Intravenous
37 Adjuvants, Anesthesia
38 Fluorides Not Applicable

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Conservative Treatment Versus Elective Repair of Umbilical Hernia in Patients With Ascites and Liver Cirrhosis Unknown status NCT01421550 Phase 3
2 Does Preoperative Caldolor Decrease the Requirement for Postoperative Narcotics Unknown status NCT01297829 Phase 3 Intravenous Ibuprofen
3 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3
4 Comparative Study Matching Intraperitoneal Onlay Mesh (IPOM) and Sublay Mesh to Treat Umbilical Hernia Recruiting NCT01201564 Phase 3
5 Caudal Versus Rectus Sheath Study Terminated NCT01394523 Phase 2, Phase 3 Bupivacaine
6 North American Study for the Treatment of Refractory Ascites (NASTRA) Completed NCT00006166 Phase 3
7 Does a Transabdominal Plane Block Decrease Patient Pain After Ventral Hernia Repair? Completed NCT02007096 Phase 2 Transabdominal Plane Block;Non Transabdominal Plane Block
8 Laparoscopic or Conventional Mesh Repair of Incisional and Umbilical Hernia Unknown status NCT00970515 Not Applicable
9 The Flemish Umbilical Nitinol Mesh Trial, a Multicenter Trial Unknown status NCT01543789 Not Applicable
10 The Impact of Medical Clowning on Pain and Stress Level in Pediatric Patients Undergoing Hernia Repair Surgery LAUGH Study. Unknown status NCT01622218 Not Applicable
11 Case-control Study of Mesh-infection After a Size Tailored Hernia Repair With C-Qur V-Patch Unknown status NCT01761708
12 Primary and Secondary Ventral Hernia Repair Using Long-term Resorbable Versus Non-resorbable Large Pore Synthetic Mesh. Unknown status NCT01622725 Not Applicable
13 Intraperitoneal Mesh With 3cm Overlap Versus a Rives-Stoppa Repair With a 6cm Overlap in Hernia Umbilicalis Unknown status NCT00323141 Not Applicable
14 Visible vs. Non-Visible Mesh in Underlay Positon After Repair of Umbilical Hernias Completed NCT03200405 Not Applicable
15 Minimally Invasive Closure of Umbilical Hernias Terminated NCT00706329 Not Applicable
16 Effect of Reoperation for Recurrence After Open Umbilical Hernia Repair Completed NCT01607801
17 Analgesic Efficacy After Umbilical Hernia Repair in Children Completed NCT00578136 Not Applicable Bupivacaine
18 Mesh Versus Suture Repair for Umbilical Hernias Completed NCT00789230 Not Applicable
19 Percutaneous Rectus Sheath Block Versus Intra-operative Rectus Sheath Block for Pediatric Umbilical Hernia Repair Completed NCT02341144 Not Applicable Ropivacaine
20 Ultrasound-guided Rectus Sheath Block for Post-operative Pain Control Following Umbilical Hernia Repair Completed NCT00836134 Not Applicable
21 Risk Factors for Poor Outcome After Epigastric and Umbilical Hernia Repair Completed NCT01665859
22 Postoperative Pain After Pediatric Umbilical Hernia Repair Completed NCT01015053 Not Applicable
23 Chronic Complaints After Small Umbilical Hernia Repair Completed NCT01741740
24 Robotic Utility for Surgical Treatment of Umbilical Hernias Completed NCT02975414
25 Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High-Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric ENT Surgery (The HATT Project) Terminated NCT02095015
26 Self-Expanding Multi-Layered Partially Resorbable Lightweight Polypropylene Mesh Device (Proceed Ventral Patch® Or Pvp®) For The Treatment of Small and Medium Umbilical Ventral Hernias Completed NCT01307696
27 The Effect of Sutures Versus Mesh in Umbilical Hernia Repair Completed NCT01635868
28 Mesh Fixation With Intraperitoneal Tisseel Completed NCT00842842 Not Applicable
29 Abdominal Wall Block Study Recruiting NCT03074240 Not Applicable
30 Natural Orifice Translumenal Endoscopic Surgery (NOTES): Laparoscopic Assisted Transvaginal Ventral Hernia Repair Recruiting NCT01398215
31 Prospective Evaluation of the Proceed Ventral Patch With and Without Laparoscopic Evaluation Completed NCT01183325 Not Applicable
32 Risk of Umbilical Trocar-site Hernia After SILC Cholecystectomy Versus Conventional Cholecystectomy Completed NCT01740973
33 Watchful Waiting of Incisional Hernias Completed NCT00351455 Not Applicable
34 Quality of Life After Laparoscopic Inguinal- Incisional and Umbilical Herniotomy. Completed NCT01289093
35 Prospective Study Of A Size Tailored Approach To Repair Umbilical And Epigastric Primary Ventral Hernias Terminated NCT01639118
36 A Trial Comparing Combination Therapy of Acetaminophen Plus Ibuprofen Versus Tylenol #3 for the Treatment of Pain After Outpatient Surgery Completed NCT00245375 Not Applicable Tylenol #3;Combination Tylenol and Ibuprofen
37 A Cross-specialty Collaboration Platform for Mucopolysaccharidosis Confirmative Diagnosis Not yet recruiting NCT03017677
38 Open Preperitoneal Mesh Versus Retromuscular Mesh Versus Suture Repair for Abdominal Wall Hernias Recruiting NCT03255239 Not Applicable
39 No Need for Neuromuscular Blockade in Daycase Laparoscopic Surgery Completed NCT02782832
40 Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy Active, not recruiting NCT02494336 Not Applicable Ropivacaine
41 Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries Recruiting NCT03666767
42 Prevalence of Sarcopenia and Undernutrition in Patients With Cirrhosis and Abdominal Hernia Recruiting NCT03458845
43 Selenium Supplementation in Pregnancy Completed NCT01465867 Not Applicable
44 A Retrospective Study With Prospective Follow-Up of Laparoscopic Ventral Hernia Repair Utilizing the Bard Sepramesh IP Composite Completed NCT01305473
45 Spinal Anesthesia for Outpatient Abdominal Wall Surgery: Comparison of Bupivacaine, 2-chloroprocaine and Prilocaine Completed NCT02813382 Bupivacaine;Prilocaine;Chloroprocaine
46 Utility of a Supraaponeurotic Mesh as Prophylaxis of the Midline Eventration After an Oncological Colorrectal Resection Recruiting NCT03520465 Not Applicable

Search NIH Clinical Center for Umbilical Hernia

Cochrane evidence based reviews: hernia, umbilical

Genetic Tests for Umbilical Hernia

Genetic tests related to Umbilical Hernia:

# Genetic test Affiliating Genes
1 Umbilical Hernia 30

Anatomical Context for Umbilical Hernia

MalaCards organs/tissues related to Umbilical Hernia:

42
Small Intestine, Uterus, Kidney, Colon, Appendix, Skin, Pancreas

Publications for Umbilical Hernia

Articles related to Umbilical Hernia:

(show top 50) (show all 526)
# Title Authors Year
1
Strangulated umbilical hernia. ( 30656888 )
2019
2
Open mesh versus suture repair of umbilical hernia: Meta-analysis of randomised controlled trials. ( 30682412 )
2019
3
Robotic simple prostatectomy plus panniculectomy and Giant umbilical hernia repair. ( 30735333 )
2019
4
Genome-wide association study identifies variants in the CAPN9 gene associated with umbilical hernia in pigs. ( 30746724 )
2019
5
Commentary on: Concomitant Abdominoplasty and Laparoscopic Umbilical Hernia Repair. ( 29924292 )
2018
6
Mesh migration into an inguinal hernia sac following a laparoscopic umbilical hernia repair. ( 29605843 )
2018
7
Variceal hemorrhage with white nipple sign associated with strangulated umbilical hernia in a patient with cirrhosis. ( 29425783 )
2018
8
Umbilical Hernia with Evisceration. Two Cases and a Review of the Literature. ( 29793813 )
2018
9
Concomitant Abdominoplasty and Laparoscopic Umbilical Hernia Repair. ( 29897393 )
2018
10
Mesh versus suture repair of umbilical hernia in adults: a randomised, double-blind, controlled, multicentre trial. ( 29459021 )
2018
11
Concurrent Umbilical Hernia Repair at the Time of Liver Transplantation: A Six-Year Experience from a Single Institution. ( 29531643 )
2018
12
Safety and effectiveness of umbilical hernia repair in patients with cirrhosis. ( 29589135 )
2018
13
Genome-wide association study reveals a QTL and strong candidate genes for umbilical hernia in pigs on SSC14. ( 29843603 )
2018
14
Importance of mesh overlap on hernia recurrence after open umbilical hernia repair with bilayer prosthesis. ( 29429547 )
2018
15
Umbilical Hernia Repair: Overview of Approaches and Review of Literature. ( 29754622 )
2018
16
Rapidly Growing Pancreatic Adenocarcinoma Presenting as an Irreducible Umbilical Hernia. ( 30009070 )
2018
17
Umbilical Cord Diameter at the Junction of the Body Wall in the Newborn. Is It a Biomarker for Congenital Umbilical Hernia? ( 30148418 )
2018
18
Retrospective analysis of smaller than 3-cm umbilical hernia repair with the lightweight macroporous mesh. ( 30200154 )
2018
19
Transumbilical repair of umbilical hernia in children: The covert scar approach. ( 30274709 )
2018
20
Umbilical hernia repair with composite prosthesis: a single-centre experience. ( 30390145 )
2018
21
Age-dependent outcomes in asymptomatic umbilical hernia repair. ( 30430281 )
2018
22
Practice Variation in Umbilical Hernia Repair Demonstrates a Need for Best Practice Guidelines. ( 30448274 )
2018
23
Lower Risk of Recurrence After Mesh Repair Versus Non-Mesh Sutured Repair in Open Umbilical Hernia Repair: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( 30488767 )
2018
24
National variation in opioid prescribing after pediatric umbilical hernia repair. ( 30509750 )
2018
25
Abdominoplasty with simultaneous laparoscopic umbilical hernia repair: A practical approach to preserve the umbilical vascularization. ( 30527353 )
2018
26
Spontaneous Endometriosis Within a Primary Umbilical Hernia. ( 29164008 )
2017
27
Laparoscopic transabdominal preperitoneal approach for umbilical hernia with rectus diastasis. ( 28727317 )
2017
28
Incarceration of a pedunculated uterine fibroid in an umbilical hernia. ( 28534020 )
2017
29
Simultaneous Abdominoplasty and Umbilical Hernia Repair via Laparoscopy: a Preliminary Report. ( 28704183 )
2017
30
Laparoscopic versus Open Repair of Para-Umbilical Hernia- A Prospective Comparative Study of Short Term Outcomes. ( 28969195 )
2017
31
Percutaneous ultrasound-guided vs. intraoperative rectus sheath block for pediatric umbilical hernia repair: A randomized clinical trial. ( 28377023 )
2017
32
Rupture of Umbilical Hernia with Evisceration in a Newborn - A Case Report. ( 28920027 )
2017
33
A new approach to umbilical hernia repair: the Circular suture technique for defects less than 2 cm. ( 28892467 )
2017
34
Umbilical appearance and patient/parent satisfaction over 5years of follow-up after umbilical hernia repair in children. ( 28629819 )
2017
35
Mesh Versus Patch Repair for Epigastric and Umbilical Hernia (MORPHEUS Trial); One-Year Results of a Randomized Controlled Trial. ( 29026977 )
2017
36
Unusual clinical umbilical hernia: pitfall. ( 28381548 )
2017
37
Spontaneous evisceration of umbilical hernia in a patient with congenital nephrotic syndrome. ( 28507377 )
2017
38
The Effect of Rectus Sheath Block as a Supplement of General Anesthesia on Postoperative Analgesia in Adult Patient Undergoing Umbilical Hernia Repair. ( 29668467 )
2017
39
Surprising Twist in the Plot - Sister Mary Joseph's Nodule of Pancreatic Cancer Mimicking Wound Infection after Umbilical Hernia Repair. ( 28589449 )
2017
40
Postoperative Pain After Laparoscopic Repair of Primary Umbilical Hernia: Titanium Tacks Versus Absorbable Tacks: A Prospective Comparative Cohort Analysis of 80 Patients With a Long-term Follow-up. ( 28915205 )
2017
41
Factors Associated With Long-term Outcomes of Umbilical Hernia Repair. ( 28122076 )
2017
42
Complexity of the "Simple" Umbilical Hernia Repair. ( 28122080 )
2017
43
The Evaluation of the Therapeutic Outcomes of Umbilical Hernia. ( 28833971 )
2017
44
Umbilical Hernia. ( 28586889 )
2017
45
The feasibility of local anesthesia for the surgical treatment of umbilical hernia: a systematic review of the literature. ( 28108822 )
2017
46
Simultaneous Umbilical Hernia Repair with Transumbilical Ventriculoperitoneal Shunt Placement. ( 28208152 )
2017
47
Long-term follow-up results of umbilical hernia repair. ( 29362649 )
2017
48
Umbilical hernia repair in pregnant patients: review of the American College of Surgeons National Surgical Quality Improvement Program. ( 28735364 )
2017
49
Flood Syndrome: Spontaneous Umbilical Hernia Rupture Leaking Ascitic Fluid-A Case Report. ( 28678688 )
2017
50
A genome-wide association study of copy number variations with umbilical hernia in swine. ( 27028052 )
2016

Variations for Umbilical Hernia

ClinVar genetic disease variations for Umbilical Hernia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 complex Pathogenic
2 46;XY;inv(6)(p22q13)dn inversion Pathogenic
3 PLOD1 NM_000302.3(PLOD1): c.1562G> A (p.Trp521Ter) single nucleotide variant Pathogenic rs1057518879 GRCh37 Chromosome 1, 12025628: 12025628
4 PLOD1 NM_000302.3(PLOD1): c.1562G> A (p.Trp521Ter) single nucleotide variant Pathogenic rs1057518879 GRCh38 Chromosome 1, 11965571: 11965571
5 PLOD1 GRCh37/hg19 1p36.22(chr1: 12019879-12028775) copy number gain Pathogenic GRCh37 Chromosome 1, 12019879: 12028775
6 PLOD1 GRCh37/hg19 1p36.22(chr1: 12019879-12028775) copy number gain Pathogenic GRCh37 Chromosome 1, 12019879: 12028775
7 PLOD1 GRCh37/hg19 1p36.22(chr1: 12019879-12028775) copy number gain Pathogenic GRCh37 Chromosome 1, 12019879: 12028775
8 subset of 29 genes:TBX1 GRCh37/hg19 22q11.21(chr22: 18894835-20311763) copy number loss Pathogenic GRCh37 Chromosome 22, 18894835: 20311763
9 ACTL6A NM_004301.4(ACTL6A): c.1129C> T (p.Arg377Trp) single nucleotide variant Likely pathogenic rs868064163 GRCh37 Chromosome 3, 179304340: 179304340
10 ACTL6A NM_004301.4(ACTL6A): c.1129C> T (p.Arg377Trp) single nucleotide variant Likely pathogenic rs868064163 GRCh38 Chromosome 3, 179586552: 179586552

Expression for Umbilical Hernia

Search GEO for disease gene expression data for Umbilical Hernia.

Pathways for Umbilical Hernia

GO Terms for Umbilical Hernia

Biological processes related to Umbilical Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to amino acid stimulus GO:0071230 9.32 DNMT3A MTOR
2 positive regulation of cell death GO:0010942 9.26 DNMT3A MTOR
3 collagen fibril organization GO:0030199 9.16 ADAMTS2 PLOD1
4 response to cocaine GO:0042220 8.96 DNMT3A MTOR
5 spinal cord development GO:0021510 8.62 ACTL6A MTOR

Sources for Umbilical Hernia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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