MCID: UMB002
MIFTS: 45

Umbilical Hernia

Categories: Gastrointestinal diseases

Aliases & Classifications for Umbilical Hernia

Summaries for Umbilical Hernia

Disease Ontology : 12 A intestinal disease characterized by the protrusion by part of the intestine though an opening in the abdominal muscles.

MalaCards based summary : Umbilical Hernia, also known as hernia, umbilical, is related to omphalocele and smith-kingsmore syndrome. An important gene associated with Umbilical Hernia is PLOD1 (Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 1), and among its related pathways/superpathways are MECP2 and Associated Rett Syndrome and EGFR Transactivation by Gastrin. The drugs Ibuprofen and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and uterus, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 An umbilical hernia is a health condition where the abdominal wall behind the navel is damaged. It may... more...

Related Diseases for Umbilical Hernia

Diseases related to Umbilical Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 omphalocele 29.5 CDKN1C PLOD1
2 smith-kingsmore syndrome 12.0
3 shprintzen-goldberg craniosynostosis syndrome 11.4
4 carpenter syndrome 2 11.3
5 hypothyroidism, congenital, nongoitrous, 2 11.1
6 fraser syndrome 1 11.1
7 ehlers-danlos syndrome, dermatosparaxis type 11.1
8 gapo syndrome 11.1
9 3mc syndrome 3 11.1
10 3mc syndrome 1 11.1
11 3mc syndrome 2 11.1
12 weaver syndrome 11.1
13 mental retardation, x-linked, syndromic, martin-probst type 11.1
14 achondrogenesis, type ib 11.1
15 fontaine progeroid syndrome 11.1
16 chromosome 6q11-q14 deletion syndrome 11.1
17 tatton-brown-rahman syndrome 11.1
18 cohen-gibson syndrome 11.1
19 hyperekplexia 4 11.1
20 bamforth syndrome 11.1
21 central congenital hypothyroidism 11.1
22 peripheral resistance to thyroid hormones 11.1
23 progeroid syndrome petty type 11.1
24 simpson-golabi-behmel syndrome 11.1
25 liver cirrhosis 10.3
26 endometriosis 10.2
27 inguinal hernia 10.1
28 liver disease 10.1
29 adenocarcinoma 10.1
30 silver-russell syndrome due to a point mutation 10.1 CDKN1C IGF2
31 spastic paraplegia 17, autosomal dominant 10.0 CDKN1C IGF2
32 silver-russell syndrome due to an imprinting defect of 11p15 10.0 H19 IGF2
33 silver-russell syndrome due to 11p15 microduplication 10.0 H19 IGF2
34 beckwith-wiedemann syndrome due to imprinting defect of 11p15 10.0 H19 IGF2
35 pancreas adenocarcinoma 10.0
36 appendicitis 10.0
37 hereditary wilms' tumor 10.0 CDKN1C IGF2
38 gestational trophoblastic neoplasm 10.0 CDKN1C H19
39 trophoblastic neoplasm 10.0 CDKN1C H19
40 fetal macrosomia 10.0 H19 IGF2
41 hydatidiform mole, recurrent, 1 9.9 CDKN1C H19
42 alcoholic liver cirrhosis 9.9
43 polycystic kidney disease 9.9
44 portal hypertension 9.9
45 intestinal perforation 9.9
46 cystadenoma 9.9
47 cystic teratoma 9.9
48 ischemia 9.9
49 teratoma 9.9
50 kidney disease 9.9

Graphical network of the top 20 diseases related to Umbilical Hernia:



Diseases related to Umbilical Hernia

Symptoms & Phenotypes for Umbilical Hernia

GenomeRNAi Phenotypes related to Umbilical Hernia according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.6 MTOR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.6 ELMO2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.6 ELMO2 MTOR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.6 ELMO2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.6 ELMO2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.6 CDKN1C ELMO2 MTOR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.6 CDKN1C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 MTOR
9 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.6 CDKN1C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.6 CDKN1C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.6 CDKN1C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.6 CDKN1C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.6 MTOR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.6 ELMO2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.6 MTOR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.6 ELMO2

MGI Mouse Phenotypes related to Umbilical Hernia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 DNMT3A IGF2 MEGF8 MTOR PLOD1

Drugs & Therapeutics for Umbilical Hernia

Drugs for Umbilical Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 3,Not Applicable 15687-27-1 3672
2
Bupivacaine Approved, Investigational Phase 2, Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
3 Liver Extracts Phase 3
4 Analgesics Phase 3,Not Applicable
5 Central Nervous System Depressants Phase 3,Phase 2,Not Applicable
6 Anti-Inflammatory Agents Phase 3,Not Applicable
7 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Not Applicable
8 Analgesics, Non-Narcotic Phase 3,Not Applicable
9 Narcotics Phase 3
10 Cyclooxygenase Inhibitors Phase 3,Not Applicable
11 Antirheumatic Agents Phase 3,Not Applicable
12 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
13 Anesthetics, Local Phase 2, Phase 3,Not Applicable
14 Anesthetics Phase 2, Phase 3,Not Applicable
15
Ropivacaine Approved Not Applicable 84057-95-4 175805 71273
16
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
17
Acetaminophen Approved Not Applicable 103-90-2 1983
18
Selenium Approved, Investigational, Vet_approved Not Applicable 7782-49-2
19
Methionine Approved, Nutraceutical Not Applicable 63-68-3 6137
20 Coagulants Not Applicable
21 Hemostatics Not Applicable
22 Fibrin Tissue Adhesive Not Applicable
23 Antipyretics Not Applicable
24 Antioxidants Not Applicable
25 Micronutrients Not Applicable
26 Trace Elements Not Applicable
27 Protective Agents Not Applicable
28 Anesthetics, General Not Applicable

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Conservative Treatment Versus Elective Repair of Umbilical Hernia in Patients With Ascites and Liver Cirrhosis Unknown status NCT01421550 Phase 3
2 Does Preoperative Caldolor Decrease the Requirement for Postoperative Narcotics Unknown status NCT01297829 Phase 3 Intravenous Ibuprofen
3 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3
4 North American Study for the Treatment of Refractory Ascites (NASTRA) Completed NCT00006166 Phase 3
5 Comparative Study Matching Intraperitoneal Onlay Mesh (IPOM) and Sublay Mesh to Treat Umbilical Hernia Recruiting NCT01201564 Phase 3
6 Caudal Versus Rectus Sheath Study Terminated NCT01394523 Phase 2, Phase 3 Bupivacaine
7 Does a Transabdominal Plane Block Decrease Patient Pain After Ventral Hernia Repair? Completed NCT02007096 Phase 2 Transabdominal Plane Block;Non Transabdominal Plane Block
8 Laparoscopic or Conventional Mesh Repair of Incisional and Umbilical Hernia Unknown status NCT00970515 Not Applicable
9 The Flemish Umbilical Nitinol Mesh Trial, a Multicenter Trial Unknown status NCT01543789 Not Applicable
10 The Impact of Medical Clowning on Pain and Stress Level in Pediatric Patients Undergoing Hernia Repair Surgery LAUGH Study. Unknown status NCT01622218 Not Applicable
11 Case-control Study of Mesh-infection After a Size Tailored Hernia Repair With C-Qur V-Patch Unknown status NCT01761708
12 Primary and Secondary Ventral Hernia Repair Using Long-term Resorbable Versus Non-resorbable Large Pore Synthetic Mesh. Unknown status NCT01622725 Not Applicable
13 Visible vs. Non-Visible Mesh in Underlay Positon After Repair of Umbilical Hernias Completed NCT03200405 Not Applicable
14 Effect of Reoperation for Recurrence After Open Umbilical Hernia Repair Completed NCT01607801
15 Analgesic Efficacy After Umbilical Hernia Repair in Children Completed NCT00578136 Not Applicable Bupivacaine
16 Mesh Versus Suture Repair for Umbilical Hernias Completed NCT00789230 Not Applicable
17 Percutaneous Rectus Sheath Block Versus Intra-operative Rectus Sheath Block for Pediatric Umbilical Hernia Repair Completed NCT02341144 Not Applicable Ropivacaine
18 Ultrasound-guided Rectus Sheath Block for Post-operative Pain Control Following Umbilical Hernia Repair Completed NCT00836134 Not Applicable
19 Risk Factors for Poor Outcome After Epigastric and Umbilical Hernia Repair Completed NCT01665859
20 Postoperative Pain After Pediatric Umbilical Hernia Repair Completed NCT01015053 Not Applicable
21 Chronic Complaints After Small Umbilical Hernia Repair Completed NCT01741740
22 Robotic Utility for Surgical Treatment of Umbilical Hernias Completed NCT02975414
23 Self-Expanding Multi-Layered Partially Resorbable Lightweight Polypropylene Mesh Device (Proceed Ventral Patch® Or Pvp®) For The Treatment of Small and Medium Umbilical Ventral Hernias Completed NCT01307696
24 The Effect of Sutures Versus Mesh in Umbilical Hernia Repair Completed NCT01635868
25 Mesh Fixation With Intraperitoneal Tisseel Completed NCT00842842 Not Applicable
26 Prospective Evaluation of the Proceed Ventral Patch With and Without Laparoscopic Evaluation Completed NCT01183325 Not Applicable
27 Risk of Umbilical Trocar-site Hernia After SILC Cholecystectomy Versus Conventional Cholecystectomy Completed NCT01740973
28 Watchful Waiting of Incisional Hernias Completed NCT00351455 Not Applicable
29 Quality of Life After Laparoscopic Inguinal- Incisional and Umbilical Herniotomy. Completed NCT01289093
30 A Trial Comparing Combination Therapy of Acetaminophen Plus Ibuprofen Versus Tylenol #3 for the Treatment of Pain After Outpatient Surgery Completed NCT00245375 Not Applicable Tylenol #3;Combination Tylenol and Ibuprofen
31 No Need for Neuromuscular Blockade in Daycase Laparoscopic Surgery Completed NCT02782832
32 Selenium Supplementation in Pregnancy Completed NCT01465867 Not Applicable
33 A Retrospective Study With Prospective Follow-Up of Laparoscopic Ventral Hernia Repair Utilizing the Bard Sepramesh IP Composite Completed NCT01305473
34 Abdominal Wall Block Study Recruiting NCT03074240 Not Applicable
35 Natural Orifice Translumenal Endoscopic Surgery (NOTES): Laparoscopic Assisted Transvaginal Ventral Hernia Repair Recruiting NCT01398215
36 Open Preperitoneal Mesh Versus Retromuscular Mesh Versus Suture Repair for Abdominal Wall Hernias Recruiting NCT03255239 Not Applicable
37 Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries Recruiting NCT03666767
38 Prevalence of Sarcopenia and Undernutrition in Patients With Cirrhosis and Abdominal Hernia Recruiting NCT03458845
39 Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy Active, not recruiting NCT02494336 Not Applicable Ropivacaine
40 A Cross-specialty Collaboration Platform for Mucopolysaccharidosis Confirmative Diagnosis Not yet recruiting NCT03017677
41 Minimally Invasive Closure of Umbilical Hernias Terminated NCT00706329 Not Applicable
42 Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High-Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric ENT Surgery (The HATT Project) Terminated NCT02095015
43 Prospective Study Of A Size Tailored Approach To Repair Umbilical And Epigastric Primary Ventral Hernias Terminated NCT01639118

Search NIH Clinical Center for Umbilical Hernia

Cochrane evidence based reviews: hernia, umbilical

Genetic Tests for Umbilical Hernia

Genetic tests related to Umbilical Hernia:

# Genetic test Affiliating Genes
1 Umbilical Hernia 29

Anatomical Context for Umbilical Hernia

MalaCards organs/tissues related to Umbilical Hernia:

41
Small Intestine, Liver, Uterus, Kidney, Colon, Pancreas, Thyroid

Publications for Umbilical Hernia

Articles related to Umbilical Hernia:

(show top 50) (show all 522)
# Title Authors Year
1
Commentary on: Concomitant Abdominoplasty and Laparoscopic Umbilical Hernia Repair. ( 29924292 )
2018
2
Mesh migration into an inguinal hernia sac following a laparoscopic umbilical hernia repair. ( 29605843 )
2018
3
Variceal hemorrhage with white nipple sign associated with strangulated umbilical hernia in a patient with cirrhosis. ( 29425783 )
2018
4
Umbilical Hernia with Evisceration. Two Cases and a Review of the Literature. ( 29793813 )
2018
5
Concomitant Abdominoplasty and Laparoscopic Umbilical Hernia Repair. ( 29897393 )
2018
6
Mesh versus suture repair of umbilical hernia in adults: a randomised, double-blind, controlled, multicentre trial. ( 29459021 )
2018
7
Concurrent Umbilical Hernia Repair at the Time of Liver Transplantation: A Six-Year Experience from a Single Institution. ( 29531643 )
2018
8
Safety and effectiveness of umbilical hernia repair in patients with cirrhosis. ( 29589135 )
2018
9
Genome-wide association study reveals a QTL and strong candidate genes for umbilical hernia in pigs on SSC14. ( 29843603 )
2018
10
Importance of mesh overlap on hernia recurrence after open umbilical hernia repair with bilayer prosthesis. ( 29429547 )
2018
11
Umbilical Hernia Repair: Overview of Approaches and Review of Literature. ( 29754622 )
2018
12
Rapidly Growing Pancreatic Adenocarcinoma Presenting as an Irreducible Umbilical Hernia. ( 30009070 )
2018
13
Umbilical Cord Diameter at the Junction of the Body Wall in the Newborn. Is It a Biomarker for Congenital Umbilical Hernia? ( 30148418 )
2018
14
Retrospective analysis of smaller than 3-cm umbilical hernia repair with the lightweight macroporous mesh. ( 30200154 )
2018
15
Transumbilical repair of umbilical hernia in children: The covert scar approach. ( 30274709 )
2018
16
Umbilical hernia repair with composite prosthesis: a single-centre experience. ( 30390145 )
2018
17
Age-dependent outcomes in asymptomatic umbilical hernia repair. ( 30430281 )
2018
18
Practice Variation in Umbilical Hernia Repair Demonstrates a Need for Best Practice Guidelines. ( 30448274 )
2018
19
Lower Risk of Recurrence After Mesh Repair Versus Non-Mesh Sutured Repair in Open Umbilical Hernia Repair: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( 30488767 )
2018
20
National variation in opioid prescribing after pediatric umbilical hernia repair. ( 30509750 )
2018
21
Abdominoplasty with simultaneous laparoscopic umbilical hernia repair: A practical approach to preserve the umbilical vascularization. ( 30527353 )
2018
22
Spontaneous Endometriosis Within a Primary Umbilical Hernia. ( 29164008 )
2017
23
Laparoscopic transabdominal preperitoneal approach for umbilical hernia with rectus diastasis. ( 28727317 )
2017
24
Incarceration of a pedunculated uterine fibroid in an umbilical hernia. ( 28534020 )
2017
25
Simultaneous Abdominoplasty and Umbilical Hernia Repair via Laparoscopy: a Preliminary Report. ( 28704183 )
2017
26
Laparoscopic versus Open Repair of Para-Umbilical Hernia- A Prospective Comparative Study of Short Term Outcomes. ( 28969195 )
2017
27
Percutaneous ultrasound-guided vs. intraoperative rectus sheath block for pediatric umbilical hernia repair: A randomized clinical trial. ( 28377023 )
2017
28
Rupture of Umbilical Hernia with Evisceration in a Newborn - A Case Report. ( 28920027 )
2017
29
A new approach to umbilical hernia repair: the Circular suture technique for defects less than 2 cm. ( 28892467 )
2017
30
Umbilical appearance and patient/parent satisfaction over 5years of follow-up after umbilical hernia repair in children. ( 28629819 )
2017
31
Mesh Versus Patch Repair for Epigastric and Umbilical Hernia (MORPHEUS Trial); One-Year Results of a Randomized Controlled Trial. ( 29026977 )
2017
32
Unusual clinical umbilical hernia: pitfall. ( 28381548 )
2017
33
Spontaneous evisceration of umbilical hernia in a patient with congenital nephrotic syndrome. ( 28507377 )
2017
34
The Effect of Rectus Sheath Block as a Supplement of General Anesthesia on Postoperative Analgesia in Adult Patient Undergoing Umbilical Hernia Repair. ( 29668467 )
2017
35
Surprising Twist in the Plot - Sister Mary Joseph's Nodule of Pancreatic Cancer Mimicking Wound Infection after Umbilical Hernia Repair. ( 28589449 )
2017
36
Postoperative Pain After Laparoscopic Repair of Primary Umbilical Hernia: Titanium Tacks Versus Absorbable Tacks: A Prospective Comparative Cohort Analysis of 80 Patients With a Long-term Follow-up. ( 28915205 )
2017
37
Factors Associated With Long-term Outcomes of Umbilical Hernia Repair. ( 28122076 )
2017
38
Complexity of the "Simple" Umbilical Hernia Repair. ( 28122080 )
2017
39
The Evaluation of the Therapeutic Outcomes of Umbilical Hernia. ( 28833971 )
2017
40
Umbilical Hernia. ( 28586889 )
2017
41
The feasibility of local anesthesia for the surgical treatment of umbilical hernia: a systematic review of the literature. ( 28108822 )
2017
42
Simultaneous Umbilical Hernia Repair with Transumbilical Ventriculoperitoneal Shunt Placement. ( 28208152 )
2017
43
Long-term follow-up results of umbilical hernia repair. ( 29362649 )
2017
44
Umbilical hernia repair in pregnant patients: review of the American College of Surgeons National Surgical Quality Improvement Program. ( 28735364 )
2017
45
Flood Syndrome: Spontaneous Umbilical Hernia Rupture Leaking Ascitic Fluid-A Case Report. ( 28678688 )
2017
46
A genome-wide association study of copy number variations with umbilical hernia in swine. ( 27028052 )
2016
47
Intestinal blood flow assessment by indocyanine green fluorescence imaging in a patient with the incarcerated umbilical hernia: Report of a case. ( 27257484 )
2016
48
A complication to remember: stitch sinus following laparoscopic umbilical hernia repair. ( 27572679 )
2016
49
Mucinous cystadenoma of the appendix presenting as an umbilical hernia: A case report. ( 27313766 )
2016
50
Spontaneous endometriosis associated with an umbilical hernia: A case report and review of the literature. ( 27898348 )
2016

Variations for Umbilical Hernia

ClinVar genetic disease variations for Umbilical Hernia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PLOD1 NM_000302.3(PLOD1): c.1562G> A (p.Trp521Ter) single nucleotide variant Pathogenic rs1057518879 GRCh37 Chromosome 1, 12025628: 12025628
2 PLOD1 NM_000302.3(PLOD1): c.1562G> A (p.Trp521Ter) single nucleotide variant Pathogenic rs1057518879 GRCh38 Chromosome 1, 11965571: 11965571
3 PLOD1 GRCh37/hg19 1p36.22(chr1: 12019879-12028775) copy number gain Pathogenic GRCh37 Chromosome 1, 12019879: 12028775
4 PLOD1 GRCh37/hg19 1p36.22(chr1: 12019879-12028775) copy number gain Pathogenic GRCh37 Chromosome 1, 12019879: 12028775
5 PLOD1 GRCh37/hg19 1p36.22(chr1: 12019879-12028775) copy number gain Pathogenic GRCh37 Chromosome 1, 12019879: 12028775
6 subset of 29 genes:TBX1 GRCh37/hg19 22q11.21(chr22: 18894835-20311763) copy number loss Pathogenic GRCh37 Chromosome 22, 18894835: 20311763
7 ACTL6A NM_004301.4(ACTL6A): c.1129C> T (p.Arg377Trp) single nucleotide variant Likely pathogenic rs868064163 GRCh37 Chromosome 3, 179304340: 179304340
8 ACTL6A NM_004301.4(ACTL6A): c.1129C> T (p.Arg377Trp) single nucleotide variant Likely pathogenic rs868064163 GRCh38 Chromosome 3, 179586552: 179586552

Expression for Umbilical Hernia

Search GEO for disease gene expression data for Umbilical Hernia.

Pathways for Umbilical Hernia

Pathways related to Umbilical Hernia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 IGF2 MTOR
2
Show member pathways
10.04 IGF2 MTOR

GO Terms for Umbilical Hernia

Biological processes related to Umbilical Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to amino acid stimulus GO:0071230 9.37 DNMT3A MTOR
2 positive regulation of cell death GO:0010942 9.32 DNMT3A MTOR
3 collagen fibril organization GO:0030199 9.26 ADAMTS2 PLOD1
4 response to cocaine GO:0042220 9.16 DNMT3A MTOR
5 regulation of gene expression by genetic imprinting GO:0006349 8.96 DNMT3A IGF2
6 embryonic placenta morphogenesis GO:0060669 8.62 CDKN1C IGF2

Sources for Umbilical Hernia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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