MCID: UND007
MIFTS: 27

Undifferentiated Connective Tissue Disease

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Undifferentiated Connective Tissue Disease

MalaCards integrated aliases for Undifferentiated Connective Tissue Disease:

Name: Undifferentiated Connective Tissue Disease 53 73
Undifferentiated Connective Tissue Syndrome 53 59
Uctd 53 59

Classifications:



External Ids:

Orphanet 59 ORPHA90002
UMLS via Orphanet 74 C0409999
ICD10 via Orphanet 34 M35.8
UMLS 73 C0409999

Summaries for Undifferentiated Connective Tissue Disease

NIH Rare Diseases : 53 Undifferentiated connective tissue disease is a condition that affects the joints and muscles of the body. A disorder is classified as undifferentiated connective tissue disease when it cannot be classified as another type of connective tissue disease, such as rheumatoid arthritis or lupus. Symptoms of undifferentiated connective tissue disease may vary but include constriction of the blood vessels in the hands and feet, especially in response to cold (Raynaud phenomenon), sensitivity to light, joint pain (arthralgia), muscle weakness, and dryness in the eyes and mouth. Undifferentiated connective tissue disease is most likely to occur in Caucasian women in their 40s-60s. Undifferentiated connective tissue disease is a type of autoimmune disease. This means that the system of the body that is responsible for protection from infection (immune system) is attacking the body itself. The cause of most autoimmune diseases is unknown, but is thought to include both environmental and genetic factors. Diagnosis of undifferentiated connective tissue disease can be obtained through blood tests and imaging (CT scan) of the chest. Treatment includes non-steroidal anti-inflammatory drugs (NSAIDs) and avoiding exposure to extreme temperatures. 

MalaCards based summary : Undifferentiated Connective Tissue Disease, also known as undifferentiated connective tissue syndrome, is related to connective tissue disease and pneumonia. An important gene associated with Undifferentiated Connective Tissue Disease is SSB (Sjogren Syndrome Antigen B). The drugs Vaccines and Immunoglobulin G have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and lung.

Related Diseases for Undifferentiated Connective Tissue Disease

Diseases related to Undifferentiated Connective Tissue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 connective tissue disease 10.8
2 pneumonia 10.2
3 lung disease 10.1
4 scleroderma, familial progressive 10.1
5 interstitial lung disease 10.1
6 systemic lupus erythematosus 10.0
7 lupus erythematosus 10.0
8 biliary cirrhosis, primary, 1 9.9
9 protein-losing enteropathy 9.9
10 vasculitis 9.9
11 rheumatoid arthritis 9.9
12 rheumatic disease 9.9
13 primary biliary cholangitis 9.9
14 enthesopathy 9.9
15 endotheliitis 9.9
16 arthritis 9.9
17 nonspecific interstitial pneumonia 9.9
18 hepatitis 9.9
19 primary biliary cirrhosis 9.9
20 autoimmune disease 9.8
21 pulmonary fibrosis 9.8
22 thyroiditis 9.8
23 lambert-eaton myasthenic syndrome 9.8
24 localized scleroderma 9.8
25 partial lipodystrophy 9.8
26 myositis 9.8
27 pulmonary fibrosis, idiopathic 9.8
28 cardiac tamponade 9.8
29 scleritis 9.8
30 antisynthetase syndrome 9.8
31 lymphocytic vasculitis 9.8
32 heart block, congenital 9.8
33 calcinosis 9.8
34 autoimmune disease 1 9.8
35 fibromyalgia 9.8
36 lipodystrophy, partial, acquired 9.8
37 dermatitis 9.8
38 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
39 idiopathic interstitial pneumonia 9.8
40 primary anetoderma 9.8
41 hepatitis b 9.8
42 mixed connective tissue disease 9.8
43 neuromyelitis optica 9.8
44 atrial standstill 1 9.8

Graphical network of the top 20 diseases related to Undifferentiated Connective Tissue Disease:



Diseases related to Undifferentiated Connective Tissue Disease

Symptoms & Phenotypes for Undifferentiated Connective Tissue Disease

Drugs & Therapeutics for Undifferentiated Connective Tissue Disease

Drugs for Undifferentiated Connective Tissue Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines
2 Immunoglobulin G
3 Antibodies
4 Immunoglobulins
5 Autoantibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Undifferentiated Connective Tissue Disease Registry Recruiting NCT02234388
2 Metabolomic Analysis of Systemic Sclerosis Recruiting NCT02298777
3 Comparative Autoantibody and Immunologic Cell Marker Study Enrolling by invitation NCT02422875

Search NIH Clinical Center for Undifferentiated Connective Tissue Disease

Genetic Tests for Undifferentiated Connective Tissue Disease

Anatomical Context for Undifferentiated Connective Tissue Disease

MalaCards organs/tissues related to Undifferentiated Connective Tissue Disease:

41
Testes, Eye, Lung, Bone, Endothelial, T Cells, Heart

Publications for Undifferentiated Connective Tissue Disease

Articles related to Undifferentiated Connective Tissue Disease:

(show top 50) (show all 86)
# Title Authors Year
1
Overlap of interstitial pneumonia with autoimmune features with undifferentiated connective tissue disease and contribution of UIP to mortality. ( 29320807 )
2018
2
Podocyte Infolding Glomerulopathy (PIG) in a Patient With Undifferentiated Connective Tissue Disease: A CaseA Report. ( 29395482 )
2018
3
Undifferentiated connective tissue disease, fibromyalgia and the environmental factors. ( 28368979 )
2017
4
Undifferentiated connective tissue disease: predictors of evolution into definite disease. ( 28770704 )
2017
5
Cardiac involvement in undifferentiated connective tissue disease at risk for systemic sclerosis (otherwise referred to as very early-early systemic sclerosis): a TDI study. ( 28993902 )
2017
6
Primary anetoderma with undifferentiated connective tissue disease. ( 29447658 )
2017
7
Are the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) and the undifferentiated connective tissue disease (UCTD) related to each other? A case-control study of environmental exposures. ( 28332072 )
2017
8
Intracranial lesion as onset symptom in a patient with early undifferentiated connective tissue disease: a case report. ( 28476103 )
2017
9
The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease: case reports and a review of the literature. ( 27427300 )
2016
10
CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc). ( 27650429 )
2016
11
Application of SLICC classification criteria in undifferentiated connective tissue disease and evolution in systemic lupus erythematosus: analysis of a large monocentric cohort with a long-term follow-up. ( 27703051 )
2016
12
Undifferentiated Connective Tissue Disease, Mixed Connective Tissue Disease, and Overlap Syndromes in Rheumatology. ( 27311225 )
2016
13
Undifferentiated connective tissue disease and interstitial lung disease: Trying to define patterns. ( 27979657 )
2016
14
Undifferentiated Connective Tissue Disease at risk for systemic sclerosis (SSc) (so far referred to as very early/early SSc or pre-SSc). ( 25461837 )
2015
15
Broader criteria of undifferentiated connective tissue disease in idiopathic interstitial pneumonias. ( 25682542 )
2015
16
Mechanic's hands in a woman with undifferentiated connective tissue disease and interstitial lung disease - anti-PL7 positive antisynthetase syndrome: a case report. ( 25888844 )
2015
17
Interstitial pneumonia with autoimmune features and undifferentiated connective tissue disease: Our interdisciplinary rheumatology-pneumology experience, and review of the literature. ( 26384526 )
2015
18
High prevalence of gluten sensitivity in a cohort of patients with undifferentiated connective tissue disease. ( 25781195 )
2015
19
Case Report and Literature Review: Quinacrine-induced Cholestatic Hepatitis in Undifferentiated Connective Tissue Disease. ( 26136554 )
2015
20
Interstitial Pneumonia Related to Undifferentiated Connective Tissue Disease: Pathologic Pattern and Prognosis. ( 25211168 )
2014
21
Vocal fold bamboo nodes in undifferentiated connective tissue disease. ( 25118316 )
2014
22
Impaired endothelial function in patients with undifferentiated connective tissue disease: a follow-up study. ( 24917564 )
2014
23
Cytokine Milieu in Undifferentiated Connective Tissue Disease: a Comprehensive Review. ( 25274451 )
2014
24
Recurrent epistaxis revealing a non-catheter-related superior vena cava syndrome in a hemodialysis patient: Unmasking undifferentiated connective tissue disease. ( 24434394 )
2014
25
Increased expression of vascular endothelial growth factor in a case of protein-losing enteropathy with undifferentiated connective tissue disease. ( 24899168 )
2014
26
Capillaroscopic pattern in systemic lupus erythematosus and undifferentiated connective tissue disease: what we still have to learn? ( 22527142 )
2013
27
Hepatitis B vaccination and undifferentiated connective tissue disease: another brick in the wall of the autoimmune/inflammatory syndrome induced by adjuvants (Asia). ( 23884184 )
2013
28
Undifferentiated connective tissue disease in a rheumatology center in Cali, Colombia: clinical features of 94 patients followed for a year. ( 22116525 )
2013
29
Assessment of T regulatory cells and expanded profiling of autoantibodies may offer novel biomarkers for the clinical management of systemic sclerosis and undifferentiated connective tissue disease. ( 23818915 )
2013
30
Comparison of characteristics of connective tissue disease-associated interstitial lung diseases, undifferentiated connective tissue disease-associated interstitial lung diseases, and idiopathic pulmonary fibrosis in Chinese Han population: a retrospective study. ( 24171031 )
2013
31
Quality of life as measured by the short-form 36 (SF-36) questionnaire in patients with early systemic sclerosis and undifferentiated connective tissue disease. ( 23442975 )
2013
32
Conductor of regulatory cells: does vitamin D restore the shifted balance of the distinct regulatory cell types in undifferentiated connective tissue disease? ( 23500533 )
2013
33
Intrapleural corticosteroid injection in eosinophilic pleural effusion associated with undifferentiated connective tissue disease. ( 24265645 )
2013
34
Recurrent orbital myositis in undifferentiated connective tissue disease. ( 22840478 )
2013
35
Altered Th17 cells and Th17/regulatory T-cell ratios indicate the subsequent conversion from undifferentiated connective tissue disease to definitive systemic autoimmune disorders. ( 23974054 )
2013
36
An unusual case of undifferentiated connective tissue disease presenting as cardiac tamponade. ( 20013265 )
2012
37
Acute fibrinous and organizing pneumonia and undifferentiated connective tissue disease: a case report. ( 22957292 )
2012
38
Undifferentiated connective tissue disease presenting with prevalent interstitial lung disease: case report and review of literature. ( 21645423 )
2011
39
Pregnancy in patients with undifferentiated connective tissue disease: a prospective case-control study. ( 21813586 )
2011
40
Undifferentiated connective tissue disease with pulmonary involvement. ( 21751630 )
2011
41
Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue disease. ( 20868777 )
2011
42
Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function. ( 20069430 )
2010
43
Undifferentiated connective tissue disease - an unsolved problem:revision of literature and case studies. ( 20378013 )
2010
44
Late onset of pANCA renal and pulmonary vasculitis in a girl affected by undifferentiated connective tissue disease. ( 20133348 )
2010
45
A case of hypertrophic cranial pachymeningitis presenting with scleritis in a patient with undifferentiated connective tissue disease. ( 20514324 )
2010
46
Impaired regulatory T-cell homeostasis due to vitamin D deficiency in undifferentiated connective tissue disease. ( 20615161 )
2010
47
Distinct prognosis of idiopathic nonspecific interstitial pneumonia (NSIP) fulfilling criteria for undifferentiated connective tissue disease (UCTD). ( 20483576 )
2010
48
Neonatal lupus in triplet pregnancy of a patient with undifferentiated connective tissue disease evolving to systemic lupus erythematosus. ( 19276307 )
2009
49
Undifferentiated connective tissue disease: a seven-center cross-sectional study of 184 patients. ( 19390908 )
2009
50
Isotype switching and titer variation of anti-Ro/SSA antibodies over time in 100 patients with undifferentiated connective tissue disease (UCTD). ( 18328157 )
2008

Variations for Undifferentiated Connective Tissue Disease

Expression for Undifferentiated Connective Tissue Disease

Search GEO for disease gene expression data for Undifferentiated Connective Tissue Disease.

Pathways for Undifferentiated Connective Tissue Disease

GO Terms for Undifferentiated Connective Tissue Disease

Sources for Undifferentiated Connective Tissue Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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