UCTD
MCID: UND007
MIFTS: 29

Undifferentiated Connective Tissue Disease (UCTD)

Categories: Bone diseases, Rare diseases, Skin diseases

Aliases & Classifications for Undifferentiated Connective Tissue Disease

MalaCards integrated aliases for Undifferentiated Connective Tissue Disease:

Name: Undifferentiated Connective Tissue Disease 20 70
Undifferentiated Connective Tissue Syndrome 20 58
Uctd 20 58

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases


External Ids:

ICD10 via Orphanet 33 M35.8
UMLS via Orphanet 71 C0409999
Orphanet 58 ORPHA90002
UMLS 70 C0409999

Summaries for Undifferentiated Connective Tissue Disease

GARD : 20 Undifferentiated connective tissue disease (UCTD) is an autoimmune disease that can affect several systems in the body. Connective tissue disease (CTD) is classified as undifferentiated CTD when signs and symptoms are consistent with a CTD, but do not fulfill the diagnostic or classification criteria for one of the previously defined CTDs (for example, rheumatoid arthritis or lupus ). Symptoms of UCTD vary, but more common symptoms include Raynaud phenomenon, arthritis, joint pain, fever, and symptoms involving the mucous membranes and skin such as dryness in the eyes and mouth, ulcers in the mouth, sensitivity to sunlight (photosensitivity), or hair loss. Various other symptoms may be present and may additionally involve the lungs, heart, muscles, or nervous system. The underlying cause of UCTD is unknown, but it is a type of autoimmune disease, which means that the immune system malfunctions and mistakenly attacks a person's own healthy tissues. The diagnosis is made by ruling out other conditions that can cause the same symptoms, aided by blood and urine tests, and imaging studies such as X-ray, CT scan, or ultrasound. Treatment usually includes the use of non-steroidal anti-inflammatory drugs (NSAIDs), antimalarial drugs, and/or corticosteroids. People with photosensitivity may be helped by avoiding prolonged exposure to sunlight, and those with Raynaud phenomenon should avoid exposure to extremely cold temperatures.

MalaCards based summary : Undifferentiated Connective Tissue Disease, also known as undifferentiated connective tissue syndrome, is related to connective tissue disease and systemic lupus erythematosus. An important gene associated with Undifferentiated Connective Tissue Disease is SSB (Small RNA Binding Exonuclease Protection Factor La). The drugs Hydroxychloroquine and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and eye.

Wikipedia : 73 Undifferentiated connective tissue disease (UCTD) is a disease in which the body mistakenly attacks its... more...

Related Diseases for Undifferentiated Connective Tissue Disease

Diseases related to Undifferentiated Connective Tissue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 connective tissue disease 31.1 VEGFA SSB
2 systemic lupus erythematosus 29.8 VEGFA SSB
3 raynaud phenomenon 10.7
4 scleroderma, familial progressive 10.7
5 systemic scleroderma 10.6
6 autoimmune disease 10.5
7 lung disease 10.5
8 interstitial lung disease 10.5
9 pulmonary fibrosis, idiopathic 10.4
10 nonspecific interstitial pneumonia 10.4
11 mixed connective tissue disease 10.4
12 pulmonary fibrosis 10.4
13 pneumonia 10.4
14 exanthem 10.4
15 idiopathic interstitial pneumonia 10.4
16 vasculitis 10.4
17 lupus erythematosus 10.4
18 dermatomyositis 10.4
19 neutropenia 10.4
20 rickets 10.3
21 systemic autoimmune disease 10.3
22 myositis 10.3
23 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
24 polymyositis 10.3
25 pre-eclampsia 10.3
26 heart block, congenital 10.2
27 proteinuria, chronic benign 10.2
28 xerophthalmia 10.2
29 protein-losing enteropathy 10.2
30 primary biliary cholangitis 10.2
31 keratoconjunctivitis sicca 10.2
32 eclampsia 10.2
33 hypothyroidism 10.2
34 thrombocytopenia 10.2
35 vascular disease 10.2
36 liver cirrhosis 10.2
37 irritable bowel syndrome 10.2
38 alopecia 10.2
39 hypereosinophilic syndrome 10.2
40 dysphagia 10.2
41 spondyloarthropathy 1 10.0
42 atherosclerosis susceptibility 10.0
43 gastroesophageal reflux 10.0
44 fibrosis of extraocular muscles, congenital, 1 10.0
45 hashimoto thyroiditis 10.0
46 raynaud disease 10.0
47 sarcoidosis 1 10.0
48 temporal arteritis 10.0
49 vasculitis, lymphocytic, nodular 10.0
50 celiac disease 1 10.0

Graphical network of the top 20 diseases related to Undifferentiated Connective Tissue Disease:



Diseases related to Undifferentiated Connective Tissue Disease

Symptoms & Phenotypes for Undifferentiated Connective Tissue Disease

Drugs & Therapeutics for Undifferentiated Connective Tissue Disease

Drugs for Undifferentiated Connective Tissue Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxychloroquine Approved 118-42-3 3652
2
Prednisone Approved, Vet_approved 53-03-2 5865
3
Enoxaparin Approved 9005-49-6 772
4
Nadroparin Approved, Investigational
5
Dalteparin Approved 9005-49-6
6
Aspirin Approved, Vet_approved 50-78-2 2244
7
Heparin Approved, Investigational 9005-49-6 772 9812414
8
Tinzaparin Approved 9041-08-1, 9005-49-6 25244225
9 Fibrinolytic Agents
10 Antirheumatic Agents
11 Hormones
12 Immunosuppressive Agents
13 Antiparasitic Agents
14 Hormone Antagonists
15 Antineoplastic Agents, Hormonal
16 Anti-Inflammatory Agents
17 Cyclooxygenase Inhibitors
18 glucocorticoids
19 Platelet Aggregation Inhibitors
20 Heparin, Low-Molecular-Weight
21 Anti-Infective Agents
22 calcium heparin
23 Antimalarials
24 Antipyretics
25 Calcium, Dietary
26 Antiprotozoal Agents
27 Analgesics
28 Anti-Inflammatory Agents, Non-Steroidal
29 Anticoagulants
30 Analgesics, Non-Narcotic
31
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Three-arm, Multicenter, Open-label Randomized Controlled Trial of Hydroxychloroquine and Low-dose Prednisone on Recurrent Spontaneous Abortion With Undifferentiated Connective Tissue Diseases: Protocol for the Immunosuppressant Regimens for Living FEtuses (ILIFE) Trial Recruiting NCT03671174 Prednisone;Hydroxychloroquine;Aspirin;low molecular weight heparin
2 Undifferentiated Connective Tissue Disease Registry Recruiting NCT02234388

Search NIH Clinical Center for Undifferentiated Connective Tissue Disease

Genetic Tests for Undifferentiated Connective Tissue Disease

Anatomical Context for Undifferentiated Connective Tissue Disease

MalaCards organs/tissues related to Undifferentiated Connective Tissue Disease:

40
Lung, Endothelial, Eye, Thymus, Neutrophil, Heart, Kidney

Publications for Undifferentiated Connective Tissue Disease

Articles related to Undifferentiated Connective Tissue Disease:

(show top 50) (show all 359)
# Title Authors PMID Year
1
Application of SLICC classification criteria in undifferentiated connective tissue disease and evolution in systemic lupus erythematosus: analysis of a large monocentric cohort with a long-term follow-up. 20 61
27703051 2017
2
[Undifferentiated connective tissue disease : what is it ?] 61
33689247 2021
3
Undifferentiated connective tissue disease at risk for systemic sclerosis: Development of a short-term predictive score and a risk stratification tool. 61
33476821 2021
4
The Psychosocial Impact of Undifferentiated Connective Tissue Disease on Patient Health and Well-Being: A Qualitative Study. 61
33657588 2021
5
Porphyria cutanea tarda exacerbation as a paraneoplastic syndrome in vaginal cancer resolved with chemoradiation. 61
33426257 2021
6
Applying SLICC and ACR/EULAR systemic lupus erythematosus classification criteria in a cohort of patients with undifferentiated connective tissue disease. 61
33252299 2021
7
Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease. 61
33557386 2021
8
Efficacy and safety of mycophenolate mofetil in the treatment of rheumatic disease-related interstitial lung disease: a narrative review. 61
33505480 2021
9
Ocular Manifestations in Rheumatoid Arthritis, Connective Tissue Disease, and Vasculitis: A Systematic Review and Metaanalysis. 61
32358156 2021
10
Antiphospholipid autoantibody detection is important in all patients with systemic autoimmune diseases. 61
32693965 2020
11
Endothelial Progenitor Cell CD34+ and CD133+ Concentrations and Soluble HLA-G Concentrations During Pregnancy and in Cord Blood in Undifferentiated Connective Tissue Diseases Compared to Controls. 61
33237511 2020
12
Diffused coronary arteritis in undifferentiated connective tissue disease identified with coronary atherosclerosis T1-weighted charac terization (CATCH). 61
33152059 2020
13
Undifferentiated connective tissue disease at risk for systemic sclerosis: Which patients might be labeled prescleroderma? 61
32942034 2020
14
Performance of the 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus in Asian patients: a single-centre retrospective cohort study in Korea. 61
32083550 2020
15
Classical Examples of the Concept of the ASIA Syndrome. 61
33053910 2020
16
A multicentre study of 244 pregnancies in undifferentiated connective tissue disease: maternal/fetal outcomes and disease evolution. 61
31943123 2020
17
A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial. 61
32907619 2020
18
Metabolic Disturbances in Urinary and Plasma Samples from Seven Different Systemic Autoimmune Diseases Detected by HPLC-ESI-QTOF-MS. 61
32460496 2020
19
Impact of the new 2019 EULAR/ACR classification criteria for Systemic Lupus Erythematosus in a multicenter cohort study of 133 women with undifferentiated connective tissue disease. 61
32702197 2020
20
IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases. 61
32620913 2020
21
State-of-the-art technologies provide new insights linking skin and blood vessel abnormalities in SSc-related disorders. 61
32320708 2020
22
Pregnancy and undifferentiated connective tissue disease: outcome and risk of flare in 100 pregnancies. 61
31593595 2020
23
Comment on: Pregnancy and undifferentiated connective tissue disease: outcome and risk of flare in 100 pregnancies: reply. 61
32176297 2020
24
Comment on: Pregnancy and undifferentiated connective tissue disease: outcome and risk of flare in 100 pregnancies. 61
32176284 2020
25
Vitamin D and connective tissue diseases. 61
32172354 2020
26
Psychological distress and quality of life are improved in autoimmune patients through Tandem-Psychotherapy, combining individual hypnosis and eye movement desensitization and reprocessing (EMDR) treatment for trauma, followed by supportive-expressive group therapy. 61
31858339 2020
27
Mesothelial/monocytic incidental cardiac excrescence in autoimmune disease. 61
31886917 2020
28
Podocyte infolding glomerulopathy with undifferentiated connective tissue disease: a case report. 61
32172632 2020
29
Nailfold capillaroscopy and autoimmune connective tissue diseases in patients from a Portuguese nailfold capillaroscopy clinic. 61
31451935 2020
30
Therapeutic Options for the Treatment of Interstitial Lung Disease Related to Connective Tissue Diseases. A Narrative Review. 61
32028635 2020
31
Coupled Plasma Filtration Adsorption for Treatment of Capillary Leak Syndrome Superimposed to Acute Generalized Exanthematous Pustolosis: A Case Report. 61
32069462 2020
32
Autoantibodies as biomarkers for interstitial lung disease in idiopathic inflammatory myositis and systemic sclerosis: The case of anti-eIF2B antibodies. 61
32743530 2020
33
The clinical phenotype associated with antisynthetase autoantibodies. 61
32322117 2020
34
The frequency of visceral and phenotypic markers in patients with the combination of undifferentiated connective tissue disease and gastroesophageal reflux disease. 61
32759444 2020
35
[A report of clinical characteristics of 2 Chinese pedigrees with haploinsufficiency of A20 and literature review]. 61
31795558 2019
36
Investigation of anti-DFS70 antibody in patients with systemic autoimmune rheumatic diseases. 61
31396837 2019
37
Progranulin autoantibodies in systemic sclerosis and autoimmune connective tissue disorders: A preliminary study. 61
31502765 2019
38
Giant Cell Hepatitis - A Rare Association with Connective Tissue Disease. 61
32467874 2019
39
Hydroxychloroquine-induced renal phospholipidosis resembling Fabry disease in undifferentiated connective tissue disease: A case report. 61
31911921 2019
40
Clinical Impact of Nailfold Capillaroscopy in Daily Clinical Practice. 61
31708452 2019
41
Fatigue severity in anti-nuclear antibody-positive individuals does not correlate with pro-inflammatory cytokine levels or predict imminent progression to symptomatic disease. 61
31685018 2019
42
Only monospecific anti-DFS70 antibodies aid in the exclusion of antinuclear antibody associated rheumatic diseases: an Italian experience. 61
31318689 2019
43
Multicentric reticulohistiocytosis in the course of undifferentiated connective tissue disease. 61
31839786 2019
44
[Clinical value of myositis antibodies in patients with connective tissue disease-associated interstitial lung diseases]. 61
31594111 2019
45
Undifferentiated connective tissue disease at risk of systemic sclerosis: A weighted score to identify patients who will evolve. 61
31323358 2019
46
Mechanic hands: clinical and capillaroscopy manifestations of patients with connective tissue diseases presented with and without mechanic hands. 61
30635856 2019
47
Rhabdomyolysis-induced acute kidney injury in a patient with undifferentiated connective tissue disease: A case report and literature review rhabdomyolysis-induced AKI in a patient with UCTD. 61
31348259 2019
48
Interstitial Pneumonia with Autoimmune Features and Undifferentiated Connective Tissue Disease. 61
31137065 2019
49
Role of lectin pathway complement proteins and genetic variants in organ damage and disease severity of systemic sclerosis: a cross-sectional study. 61
30885245 2019
50
[Venous wall weackness pathogenesis in varicose vein disease]. 61
31626242 2019

Variations for Undifferentiated Connective Tissue Disease

Expression for Undifferentiated Connective Tissue Disease

Search GEO for disease gene expression data for Undifferentiated Connective Tissue Disease.

Pathways for Undifferentiated Connective Tissue Disease

GO Terms for Undifferentiated Connective Tissue Disease

Sources for Undifferentiated Connective Tissue Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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