UCTD
MCID: UND007
MIFTS: 32

Undifferentiated Connective Tissue Disease (UCTD)

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Undifferentiated Connective Tissue Disease

MalaCards integrated aliases for Undifferentiated Connective Tissue Disease:

Name: Undifferentiated Connective Tissue Disease 54 74
Undifferentiated Connective Tissue Syndrome 54 60
Uctd 54 60

Classifications:



External Ids:

ICD10 via Orphanet 35 M35.8
UMLS via Orphanet 75 C0409999
Orphanet 60 ORPHA90002
UMLS 74 C0409999

Summaries for Undifferentiated Connective Tissue Disease

NIH Rare Diseases : 54 Undifferentiated connective tissue disease (UCTD) is an autoimmune disease that can affect several systems in the body. Connective tissue disease (CTD) is classified as undifferentiated CTD when signs and symptoms are consistent with a CTD, but do not fulfill the diagnostic or classification criteria for one of the previously defined CTDs (for example, rheumatoid arthritis or lupus). Symptoms of UCTD vary, but more common symptoms include Raynaud phenomenon, arthritis, joint pain, fever, and symptoms involving the mucous membranes and skin such as dryness in the eyes and mouth, ulcers in the mouth, sensitivity to sunlight (photosensitivity), or hair loss. Various other symptoms may be present and may additionally involve the lungs, heart, muscles, or nervous system. The underlying cause of UCTD is unknown, but it is a type of autoimmune disease, which means that the immune system malfunctions and mistakenly attacks a person's own healthy tissues. The diagnosis is made by ruling out other conditions that can cause the same symptoms, aided by blood and urine tests, and imaging studies such as X-ray, CT scan, or ultrasound. Treatment usually includes the use of non-steroidal anti-inflammatory drugs (NSAIDs), antimalarial drugs, and/or corticosteroids. People with photosensitivity may be helped by avoiding prolonged exposure to sunlight, and those with Raynaud phenomenon should avoid exposure to extremely cold temperatures.

MalaCards based summary : Undifferentiated Connective Tissue Disease, also known as undifferentiated connective tissue syndrome, is related to connective tissue disease and pneumonia. An important gene associated with Undifferentiated Connective Tissue Disease is VEGFA (Vascular Endothelial Growth Factor A). The drugs Budesonide and Hormones have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and eye.

Related Diseases for Undifferentiated Connective Tissue Disease

Diseases related to Undifferentiated Connective Tissue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 connective tissue disease 11.0
2 pneumonia 10.3
3 scleroderma, familial progressive 10.3
4 lung disease 10.3
5 systemic lupus erythematosus 10.2
6 interstitial lung disease 10.2
7 lupus erythematosus 10.2
8 autoimmune disease 10.1
9 biliary cirrhosis, primary, 1 10.1
10 rheumatoid arthritis 10.1
11 autoimmune disease 1 10.1
12 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
13 arthritis 10.1
14 hepatitis 10.1
15 primary biliary cirrhosis 10.1
16 protein-losing enteropathy 10.1
17 nonspecific interstitial pneumonia 10.1
18 vasculitis 10.1
19 primary biliary cholangitis 10.1
20 spondyloarthropathy 1 9.9
21 atrial standstill 1 9.9
22 myositis 9.9
23 pulmonary fibrosis, idiopathic 9.9
24 raynaud disease 9.9
25 renal glucosuria 9.9
26 heart block, congenital 9.9
27 sjogren syndrome 9.9
28 lipodystrophy, partial, acquired 9.9
29 glomerulonephritis 9.9
30 hepatitis b 9.9
31 neuromyelitis optica 9.9
32 pulmonary fibrosis 9.9
33 lambert-eaton myasthenic syndrome 9.9
34 cardiac tamponade 9.9
35 scleritis 9.9
36 hypothyroidism 9.9
37 calcinosis 9.9
38 dermatitis 9.9
39 idiopathic interstitial pneumonia 9.9
40 purpura 9.9
41 mixed connective tissue disease 9.9
42 spondylitis 9.9
43 localized scleroderma 9.9
44 orbital plasma cell granuloma 9.9
45 antisynthetase syndrome 9.9
46 fibrillary glomerulonephritis 9.9
47 lymphocytic vasculitis 9.9
48 fibromyalgia 9.9
49 primary anetoderma 9.9
50 distal trisomy 3p 9.9

Graphical network of the top 20 diseases related to Undifferentiated Connective Tissue Disease:



Diseases related to Undifferentiated Connective Tissue Disease

Symptoms & Phenotypes for Undifferentiated Connective Tissue Disease

Drugs & Therapeutics for Undifferentiated Connective Tissue Disease

Drugs for Undifferentiated Connective Tissue Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 4 51333-22-3 63006 5281004
2 Hormones Phase 4,Phase 2,Not Applicable
3 Adrenergic beta-Agonists Phase 4
4 Peripheral Nervous System Agents Phase 4,Not Applicable
5 Anti-Inflammatory Agents Phase 4,Not Applicable
6 Adrenergic Agonists Phase 4
7 Adrenergic beta-2 Receptor Agonists Phase 4
8 Anti-Asthmatic Agents Phase 4
9 Autonomic Agents Phase 4
10 Formoterol Fumarate Phase 4
11 Neurotransmitter Agents Phase 4
12 Hormone Antagonists Phase 4,Not Applicable
13 Bronchodilator Agents Phase 4
14 Adrenergic Agents Phase 4
15 Respiratory System Agents Phase 4
16 glucocorticoids Phase 4,Not Applicable
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Not Applicable
18
Calcium Approved, Nutraceutical Phase 2,Not Applicable 7440-70-2 271
19
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2,Not Applicable 1406-16-2
20
Vitamin D3 Approved, Nutraceutical Phase 2,Not Applicable 67-97-0 5280795 6221
21
Ergocalciferol Approved, Nutraceutical Phase 2,Not Applicable 50-14-6 5280793
22 Calcium, Dietary Phase 2,Not Applicable
23 Micronutrients Phase 2,Not Applicable
24 Trace Elements Phase 2,Not Applicable
25 Vitamins Phase 2,Not Applicable
26 Nutrients Phase 2,Not Applicable
27 Ergocalciferols Phase 2,Not Applicable
28 Vitamin D2 Phase 2,Not Applicable
29 Calciferol Phase 2,Not Applicable
30 Bone Density Conservation Agents Phase 2,Not Applicable
31
Metronidazole Approved Not Applicable 443-48-1 4173
32
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
33
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
34
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
35
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
36
Ursodeoxycholic acid Approved, Investigational Not Applicable 128-13-2 31401
37
Azathioprine Approved Not Applicable 446-86-6 2265
38
Heparin Approved, Investigational Not Applicable 9005-49-6 772 46507594
39
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
40
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
41
Enoxaparin Approved Not Applicable 9005-49-6 772
42
Nadroparin Approved, Investigational Not Applicable
43
Hydroxychloroquine Approved Not Applicable 118-42-3 3652
44
Dalteparin Approved Not Applicable 9005-49-6
45
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
46 Albuterol
47 Antiprotozoal Agents Not Applicable
48 Antibiotics, Antitubercular Not Applicable
49 Antiparasitic Agents Not Applicable
50 Anti-Bacterial Agents Not Applicable

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Differences of Small Airways Function Between Chronic Obstructive Pulmonary Disease(COPD) and Asthma-copd Overlap(ACO) Recruiting NCT03563001 Phase 4 Budesonide(160ug) and Formoterol(4.5ug) bid
2 Continuous Positive Airway Pressure Versus Noninvasive Ventilation in Patients With Overlap Syndrome Unknown status NCT01427673 Phase 3
3 This Study Include Asthma Chronic Obstructive Pulmonary Disease (COPD) Overlap Patients.Patients Were Vitamin D Deficient.Age Range 40-70 Years, Smokers.Patients Were Advised to Take Either Placebo or Vitamin D3.Lung Functions and Exercise Tolerance Were Assessed at Baseline and at 26th Weeks. Completed NCT03880734 Phase 2 Cholecalciferol
4 Cardiac Hemodynamics in Overlap Syndrome (COPD With Obstructive Sleep Apnea) Withdrawn NCT01261377 Phase 1, Phase 2 Oxygen
5 The Application of Impulse Oscillometry on the Diagnosis of ACOS,Asthma and COPD. Unknown status NCT03181152
6 Initiation of Non- Invasive Ventilation at Home Versus Hospital Among Patients With Overlap Syndrome Unknown status NCT02363413 Not Applicable
7 Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA Unknown status NCT02244957 Not Applicable Nocturnal oxygen
8 The Mixed Phenotype of Asthma and COPD: the Overlap Syndrome Completed NCT03817333
9 Auto-trilevel Ventilator for Patients With Overlap Syndrome Completed NCT01523197 Not Applicable
10 Non-interventional Study of COPD Patients With Asthma Overlap Syndrome in Viet Nam and Taiwan Completed NCT02878252
11 A Non-interventional Study to Investigate the Current Situation of Asthma-COPD Overlap Syndrome in Patients Over Age 40 With Persistent Airflow Limitation in China Completed NCT02600221
12 Impact of Vitamin D3 Administration on Cardiac Autonomic Tone in Asthma Chronic Obstructive Pulmonary Disease(COPD) Overlap Patients Completed NCT03773809 Not Applicable
13 Evaluation of Inhalation Technique in Patients With COPD, Asthma or ACOS Using a Dry Powder Device (DPI) Completed NCT03275935
14 "Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Identification With Antibiotics in Children" Completed NCT03069976 Not Applicable Metronidazole
15 Undifferentiated Connective Tissue Disease Registry Recruiting NCT02234388
16 Metabolomic Analysis of Systemic Sclerosis Recruiting NCT02298777
17 Noninvasive Positive Pressure Ventilation in Overlap Syndrome Recruiting NCT03184714 Not Applicable
18 Canadian Network for Autoimmune Liver Disease Recruiting NCT03569826
19 Small Airway Obstruction in Asthma, COPD, ACOS Recruiting NCT03423693
20 Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD Recruiting NCT02703207 Not Applicable
21 Remission Induction of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome Recruiting NCT02936596 Not Applicable Ursodeoxycholic acid combination of immunosuppressive agents;Ursodeoxycholic Acid
22 Systematic Approach for the Diagnosis and Treatment of Obstructive Lung Diseases Active, not recruiting NCT02488590 LABA + LAMA;ICS;LABA + LAMA + ICS;LABA + ICS;other
23 Comparative Autoantibody and Immunologic Cell Marker Study Enrolling by invitation NCT02422875
24 Immunosuppressant Regimens for Living Fetuses Study Not yet recruiting NCT03671174 Not Applicable Prednisone;Hydroxychloroquine;Aspirin;low molecular weight heparin
25 Continuous Positive Pressure Versus Bi-level in Overlap Syndrome Not yet recruiting NCT03766542 Not Applicable

Search NIH Clinical Center for Undifferentiated Connective Tissue Disease

Genetic Tests for Undifferentiated Connective Tissue Disease

Anatomical Context for Undifferentiated Connective Tissue Disease

MalaCards organs/tissues related to Undifferentiated Connective Tissue Disease:

42
Testes, Skin, Eye, Bone, Lung, Thyroid, T Cells

Publications for Undifferentiated Connective Tissue Disease

Articles related to Undifferentiated Connective Tissue Disease:

(show top 50) (show all 116)
# Title Authors Year
1
Overlap of interstitial pneumonia with autoimmune features with undifferentiated connective tissue disease and contribution of UIP to mortality. ( 29320807 )
2018
2
Podocyte Infolding Glomerulopathy (PIG) in a Patient With Undifferentiated Connective Tissue Disease: A CaseA Report. ( 29395482 )
2018
3
Acquired renal glucosuria in an undifferentiated connective tissue disease patient with a SLC5A2 heterozygous mutation: A case report. ( 30558067 )
2018
4
Undifferentiated connective tissue disease: state of the art on clinical practice guidelines. ( 30886731 )
2018
5
Undifferentiated connective tissue disease, fibromyalgia and the environmental factors. ( 28368979 )
2017
6
Undifferentiated connective tissue disease: predictors of evolution into definite disease. ( 28770704 )
2017
7
Cardiac involvement in undifferentiated connective tissue disease at risk for systemic sclerosis (otherwise referred to as very early-early systemic sclerosis): a TDI study. ( 28993902 )
2017
8
Primary anetoderma with undifferentiated connective tissue disease. ( 29447658 )
2017
9
Are the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) and the undifferentiated connective tissue disease (UCTD) related to each other? A case-control study of environmental exposures. ( 28332072 )
2017
10
Intracranial lesion as onset symptom in a patient with early undifferentiated connective tissue disease: a case report. ( 28476103 )
2017
11
The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease: case reports and a review of the literature. ( 27427300 )
2016
12
CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc). ( 27650429 )
2016
13
Application of SLICC classification criteria in undifferentiated connective tissue disease and evolution in systemic lupus erythematosus: analysis of a large monocentric cohort with a long-term follow-up. ( 27703051 )
2016
14
Undifferentiated Connective Tissue Disease, Mixed Connective Tissue Disease, and Overlap Syndromes in Rheumatology. ( 27311225 )
2016
15
Undifferentiated connective tissue disease and interstitial lung disease: Trying to define patterns. ( 27979657 )
2016
16
Undifferentiated Connective Tissue Disease at risk for systemic sclerosis (SSc) (so far referred to as very early/early SSc or pre-SSc). ( 25461837 )
2015
17
Broader criteria of undifferentiated connective tissue disease in idiopathic interstitial pneumonias. ( 25682542 )
2015
18
Mechanic's hands in a woman with undifferentiated connective tissue disease and interstitial lung disease - anti-PL7 positive antisynthetase syndrome: a case report. ( 25888844 )
2015
19
Interstitial pneumonia with autoimmune features and undifferentiated connective tissue disease: Our interdisciplinary rheumatology-pneumology experience, and review of the literature. ( 26384526 )
2015
20
High prevalence of gluten sensitivity in a cohort of patients with undifferentiated connective tissue disease. ( 25781195 )
2015
21
Case Report and Literature Review: Quinacrine-induced Cholestatic Hepatitis in Undifferentiated Connective Tissue Disease. ( 26136554 )
2015
22
Interstitial Pneumonia Related to Undifferentiated Connective Tissue Disease: Pathologic Pattern and Prognosis. ( 25211168 )
2014
23
Vocal fold bamboo nodes in undifferentiated connective tissue disease. ( 25118316 )
2014
24
Impaired endothelial function in patients with undifferentiated connective tissue disease: a follow-up study. ( 24917564 )
2014
25
Cytokine Milieu in Undifferentiated Connective Tissue Disease: a Comprehensive Review. ( 25274451 )
2014
26
Recurrent epistaxis revealing a non-catheter-related superior vena cava syndrome in a hemodialysis patient: Unmasking undifferentiated connective tissue disease. ( 24434394 )
2014
27
Increased expression of vascular endothelial growth factor in a case of protein-losing enteropathy with undifferentiated connective tissue disease. ( 24899168 )
2014
28
Capillaroscopic pattern in systemic lupus erythematosus and undifferentiated connective tissue disease: what we still have to learn? ( 22527142 )
2013
29
Hepatitis B vaccination and undifferentiated connective tissue disease: another brick in the wall of the autoimmune/inflammatory syndrome induced by adjuvants (Asia). ( 23884184 )
2013
30
Undifferentiated connective tissue disease in a rheumatology center in Cali, Colombia: clinical features of 94 patients followed for a year. ( 22116525 )
2013
31
Assessment of T regulatory cells and expanded profiling of autoantibodies may offer novel biomarkers for the clinical management of systemic sclerosis and undifferentiated connective tissue disease. ( 23818915 )
2013
32
Comparison of characteristics of connective tissue disease-associated interstitial lung diseases, undifferentiated connective tissue disease-associated interstitial lung diseases, and idiopathic pulmonary fibrosis in Chinese Han population: a retrospective study. ( 24171031 )
2013
33
Quality of life as measured by the short-form 36 (SF-36) questionnaire in patients with early systemic sclerosis and undifferentiated connective tissue disease. ( 23442975 )
2013
34
Conductor of regulatory cells: does vitamin D restore the shifted balance of the distinct regulatory cell types in undifferentiated connective tissue disease? ( 23500533 )
2013
35
Intrapleural corticosteroid injection in eosinophilic pleural effusion associated with undifferentiated connective tissue disease. ( 24265645 )
2013
36
Recurrent orbital myositis in undifferentiated connective tissue disease. ( 22840478 )
2013
37
Altered Th17 cells and Th17/regulatory T-cell ratios indicate the subsequent conversion from undifferentiated connective tissue disease to definitive systemic autoimmune disorders. ( 23974054 )
2013
38
An unusual case of undifferentiated connective tissue disease presenting as cardiac tamponade. ( 20013265 )
2012
39
Acute fibrinous and organizing pneumonia and undifferentiated connective tissue disease: a case report. ( 22957292 )
2012
40
Undifferentiated connective tissue disease presenting with prevalent interstitial lung disease: case report and review of literature. ( 21645423 )
2011
41
Pregnancy in patients with undifferentiated connective tissue disease: a prospective case-control study. ( 21813586 )
2011
42
Undifferentiated connective tissue disease with pulmonary involvement. ( 21751630 )
2011
43
Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue disease. ( 20868777 )
2011
44
Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function. ( 20069430 )
2010
45
Undifferentiated connective tissue disease - an unsolved problem:revision of literature and case studies. ( 20378013 )
2010
46
Late onset of pANCA renal and pulmonary vasculitis in a girl affected by undifferentiated connective tissue disease. ( 20133348 )
2010
47
A case of hypertrophic cranial pachymeningitis presenting with scleritis in a patient with undifferentiated connective tissue disease. ( 20514324 )
2010
48
Impaired regulatory T-cell homeostasis due to vitamin D deficiency in undifferentiated connective tissue disease. ( 20615161 )
2010
49
Distinct prognosis of idiopathic nonspecific interstitial pneumonia (NSIP) fulfilling criteria for undifferentiated connective tissue disease (UCTD). ( 20483576 )
2010
50
Fibrillary glomerulonephritis with prevalent IgA deposition associated with undifferentiated connective tissue disease: A case report. ( 25949407 )
2010

Variations for Undifferentiated Connective Tissue Disease

Expression for Undifferentiated Connective Tissue Disease

Search GEO for disease gene expression data for Undifferentiated Connective Tissue Disease.

Pathways for Undifferentiated Connective Tissue Disease

GO Terms for Undifferentiated Connective Tissue Disease

Molecular functions related to Undifferentiated Connective Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 8.62 SSB VEGFA

Sources for Undifferentiated Connective Tissue Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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