UES
MCID: UND001
MIFTS: 31

Undifferentiated Embryonal Sarcoma of the Liver (UES)

Categories: Cancer diseases, Fetal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Undifferentiated Embryonal Sarcoma of the Liver

MalaCards integrated aliases for Undifferentiated Embryonal Sarcoma of the Liver:

Name: Undifferentiated Embryonal Sarcoma of the Liver 58
Undifferentiated Sarcoma of the Liver 58
Embryonal Sarcoma of the Liver 58
Ues 58

Classifications:

Orphanet: 58  
Rare hepatic diseases


External Ids:

Orphanet 58 ORPHA178315

Summaries for Undifferentiated Embryonal Sarcoma of the Liver

MalaCards based summary : Undifferentiated Embryonal Sarcoma of the Liver, also known as undifferentiated sarcoma of the liver, is related to spindle cell sarcoma and sarcoma. An important gene associated with Undifferentiated Embryonal Sarcoma of the Liver is CDK4 (Cyclin Dependent Kinase 4), and among its related pathways/superpathways are DNA Damage and DNA Damage Response. Affiliated tissues include liver, breast and bone, and related phenotype is muscle.

Related Diseases for Undifferentiated Embryonal Sarcoma of the Liver

Diseases related to Undifferentiated Embryonal Sarcoma of the Liver via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 31.3 SERPINA3 MYOG MDM2
2 sarcoma 31.3 TP53 MYOG MDM2 CDK4
3 soft tissue sarcoma 30.8 TP53 MDM2
4 li-fraumeni syndrome 30.2 TP53 MDM2 CDK4
5 hepatoblastoma 30.1 TP53 SERPINA3 MDM2
6 malignant mesenchymoma 30.0 SERPINA3 MYOG MYOD1 MDM2
7 chondrosarcoma 29.7 SERPINA3 MDM2 CDK4
8 rhabdomyosarcoma 29.7 TP53 MYOG MYOD1 MDM2 CDK4
9 malignant astrocytoma 29.6 TP53 SERPINA3 MDM2 CDK4
10 embryonal sarcoma 29.5 TP53 SERPINA3 PEG3 MYOG MYOD1 MDM2
11 embryonal rhabdomyosarcoma 29.3 TP53 MYOG MYOD1 MDM2 CDK4
12 malignant fibrous histiocytoma 29.1 TP53 SERPINA3 MYOG MYOD1 MDM2 CDK4
13 rare tumor 10.7
14 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.6
15 fibrous histiocytoma 10.4
16 dysphagia 10.4
17 liver sarcoma 10.3
18 liver disease 10.3
19 hypereosinophilic syndrome 10.3
20 mediastinum liposarcoma 10.2 MDM2 CDK4
21 gastric liposarcoma 10.2 MDM2 CDK4
22 infiltrating lipoma 10.2 MDM2 CDK4
23 spindle cell liposarcoma 10.2 MDM2 CDK4
24 diffuse lipomatosis 10.2 MDM2 CDK4
25 lipoblastoma 10.2 MDM2 CDK4
26 paratesticular lipoma 10.2 MDM2 CDK4
27 lipoma of spermatic cord 10.2 MDM2 CDK4
28 adult liposarcoma 10.2 MDM2 CDK4
29 mixed liposarcoma 10.2 MDM2 CDK4
30 juxtacortical osteosarcoma 10.2 MDM2 CDK4
31 infiltrating angiolipoma 10.2 MDM2 CDK4
32 extraosseous osteosarcoma 10.2 MDM2 CDK4
33 hereditary melanoma 10.2 MDM2 CDK4
34 spindle cell lipoma 10.2 MDM2 CDK4
35 lymphangioma 10.2
36 cystic lymphangioma 10.2
37 rare lymphatic malformation 10.2
38 myositis ossificans 10.2 MDM2 CDK4
39 ischemic fasciitis 10.2 MDM2 CDK4
40 glioma susceptibility 1 10.2
41 systemic lupus erythematosus 10.2
42 schistosoma mansoni infection, susceptibility/ 10.2
43 li-fraumeni syndrome 2 10.2
44 alpha-1-antitrypsin deficiency 10.2
45 cardiac arrest 10.2
46 osteomalacia 10.2
47 brucellosis 10.2
48 disseminated intravascular coagulation 10.2
49 pericardium cancer 10.2
50 schistosomiasis 10.2

Graphical network of the top 20 diseases related to Undifferentiated Embryonal Sarcoma of the Liver:



Diseases related to Undifferentiated Embryonal Sarcoma of the Liver

Symptoms & Phenotypes for Undifferentiated Embryonal Sarcoma of the Liver

MGI Mouse Phenotypes related to Undifferentiated Embryonal Sarcoma of the Liver:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 CDK4 MDM2 MYOD1 MYOG TP53

Drugs & Therapeutics for Undifferentiated Embryonal Sarcoma of the Liver

Search Clinical Trials , NIH Clinical Center for Undifferentiated Embryonal Sarcoma of the Liver

Genetic Tests for Undifferentiated Embryonal Sarcoma of the Liver

Anatomical Context for Undifferentiated Embryonal Sarcoma of the Liver

MalaCards organs/tissues related to Undifferentiated Embryonal Sarcoma of the Liver:

40
Liver, Breast, Bone, Heart, Prostate, Skeletal Muscle, Tongue

Publications for Undifferentiated Embryonal Sarcoma of the Liver

Articles related to Undifferentiated Embryonal Sarcoma of the Liver:

(show top 50) (show all 181)
# Title Authors PMID Year
1
Undifferentiated embryonal sarcoma of the liver: A rare hepatic tumor and its related characteristic radiological features. 61
33488891 2021
2
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic mass in a pregnant woman. 61
33640792 2021
3
Undifferentiated sarcoma of the liver: Multicenter international experience of the Cooperative Soft-Tissue Sarcoma Group and Polish Paediatric Solid Tumor Group. 61
32706511 2020
4
Undifferentiated Embryonal Sarcoma of the Liver Identified after the Initial Diagnosis of a Hepatic Cyst. 61
32611966 2020
5
Undifferentiated embryonal sarcoma of the liver in adults: Retrospective analysis of a case series and systematic review. 61
32831921 2020
6
Undifferentiated embryonal sarcoma of the liver: Clinical characteristics and outcomes. 61
33195644 2020
7
Long-term survival outcomes of undifferentiated embryonal sarcoma of the liver: a pooled analysis of 308 patients. 61
31957153 2020
8
Undifferentiated embryonal sarcoma of liver: Paradoxical imaging appearance. 61
32489512 2020
9
Tumor-induced osteomalacia in an adolescent with an undifferentiated embryonal sarcoma of the liver. 61
32383825 2020
10
Hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a pathologic review. 61
32647564 2020
11
The genomic landscape of undifferentiated embryonal sarcoma of the liver is typified by C19MC structural rearrangement and overexpression combined with TP53 mutation or loss. 61
32310940 2020
12
Undifferentiated embryonal sarcoma of the liver treated with associating liver partition and portal vein ligation for staged hepatectomy in a young adult: A case report. 61
31874380 2020
13
A risk-based treatment strategy for non-rhabdomyosarcoma soft-tissue sarcomas in patients younger than 30 years (ARST0332): a Children's Oncology Group prospective study. 61
31786124 2020
14
Undifferentiated Embryonal Sarcoma of the Liver Presents as a Molecular Mimic of Parasitic Infection. 61
32140358 2020
15
Undifferentiated Embryonal Sarcoma of the Liver: a Great Masquerader. 61
30714072 2019
16
Report of seven children with undifferentiated embryonal sarcoma of the liver. 61
31503055 2019
17
Hanging Undifferentiated Embryonal Sarcoma of the Liver in Adult: an Unusual Presentation of an Aggressive Tumor. 61
29779073 2019
18
Undifferentiated embryonal sarcoma of the liver mimicking venolymphatic malformation. 61
31011382 2019
19
Undifferentiated Embryonal Sarcoma of the Liver (UESL) in Adolescents: An Unexpected Diagnosis. 61
29702542 2019
20
Undifferentiated embryonal sarcoma of the liver in elderly: Case report and review of the literature. 61
30706877 2019
21
Undifferentiated embryonal sarcoma of the liver in adult patient: A report of two cases. 61
30215049 2018
22
Undifferentiated Embryonal Sarcoma of the Liver in an Adult Patient. 61
30258736 2018
23
[A Case of Adult Undifferentiated Sarcoma of the Liver with Intraatrial Metastasis]. 61
29650847 2018
24
Unexpected Liver Embryonal Sarcoma in the Adult: Diagnosis and Treatment. 61
29971180 2018
25
Pulmonary Metastases from an Undifferentiated Embryonal Sarcoma of the Liver: A Case Report and Review. 61
30254779 2018
26
A case of adult undifferentiated embryonal sarcoma of the liver successfully treated with right trisectionectomy: a case report. 61
28144858 2017
27
Unresectable Undifferentiated Embryonal Sarcoma of the Liver in an Adult Male Treated with Chemotherapy and Orthotopic Liver Transplantation. 61
29226049 2017
28
Undifferentiated embryonal sarcoma of the liver in a child: A whole exome sequencing analysis. 61
28539230 2017
29
Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database. 61
27781381 2017
30
A single-center experience with undifferentiated embryonal sarcoma of the liver. 61
27427850 2016
31
Imaging features of undifferentiated embryonal sarcoma of the liver: a series of 15 children. 61
27562247 2016
32
The Role of Liver Transplantation in Undifferentiated Embryonal Sarcoma of the Liver in Children. 61
27438021 2016
33
Undifferentiated embryonal sarcoma of the liver in a young female: treatment with portal vein embolization and liver trisectonectomy. 61
27621753 2016
34
Undifferentiated embryonal sarcoma of the liver in an adult patient. 61
27377912 2016
35
Undifferentiated Embryonal Sarcoma of the Liver (UESL): A Single-Center Experience and Review of the Literature. 61
26925712 2016
36
Undifferentiated embryonal sarcoma of the liver with an unusual presentation: case report and review of the literature. 61
27034807 2016
37
Undifferentiated Embryonal Sarcoma of Liver. 61
26788276 2015
38
Pre-operatively misdiagnosed undifferentiated embryonal sarcoma of the liver: analysis of 16 cases. 61
26807408 2015
39
Undifferentiated embryonal sarcoma of the liver: a concise review. 61
25611111 2015
40
Pitfalls in the surgical management of undifferentiated sarcoma of the liver and benefits of preoperative chemotherapy. 61
25259441 2015
41
Repeated hepatic resections and radio-frequency ablations may improve the survival of adult undifferentiated embryonal sarcoma of the liver: report of two cases. 61
26366352 2015
42
A case of an undifferentiated embryonal sarcoma of the liver mimicking a liver abscess. 61
25364566 2014
43
Undifferentiated embryonal sarcoma of the liver mistaken for hepatic abscess in an adult. 61
25120683 2014
44
Undifferentiated sarcoma of the liver: a case study of an erythropoietin-secreting tumor. 61
24038117 2014
45
Favorable outcomes after whole abdominopelvic radiation therapy for pediatric and young adult sarcoma. 61
24798662 2014
46
Remarkable regression of a lung recurrence from an undifferentiated embryonal sarcoma of the liver treated with a DC vaccine combined with immune cells: a case report. 61
25038546 2014
47
Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: a case report and review of the literature. 61
25603636 2014
48
Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver. 61
24762610 2014
49
Undifferentiated embryonal sarcoma of liver: a multi-institutional experience with 9 cases. 61
25674229 2014
50
A Rare Case of Childhood Undifferentiated Embryonal Sarcoma of the Liver Managed Successfully. 61
26157829 2014

Variations for Undifferentiated Embryonal Sarcoma of the Liver

Expression for Undifferentiated Embryonal Sarcoma of the Liver

Search GEO for disease gene expression data for Undifferentiated Embryonal Sarcoma of the Liver.

Pathways for Undifferentiated Embryonal Sarcoma of the Liver

GO Terms for Undifferentiated Embryonal Sarcoma of the Liver

Cellular components related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.76 TP53 SERPINA3 PEG3 MYOG MYOD1 MDM2
2 chromatin GO:0000785 9.35 TP53 PEG3 MYOG MYOD1 CDK4
3 transcription factor complex GO:0005667 8.92 TP53 MYOG MYOD1 CDK4

Biological processes related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.99 TP53 PEG3 MYOG MYOD1 MDM2
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.88 TP53 PEG3 MYOG MYOD1 MDM2
3 response to drug GO:0042493 9.79 TP53 MDM2 CDK4
4 skeletal muscle cell differentiation GO:0035914 9.62 MYOG MYOD1
5 regulation of gene expression GO:0010468 9.62 PEG3 MYOD1 MDM2 CDK4
6 positive regulation of cell cycle GO:0045787 9.61 MDM2 CDK4
7 cellular response to hypoxia GO:0071456 9.61 TP53 MDM2 MALAT1
8 cellular response to estradiol stimulus GO:0071392 9.6 MYOG MYOD1
9 positive regulation of cell cycle arrest GO:0071158 9.58 TP53 MYOG
10 response to antibiotic GO:0046677 9.58 TP53 MDM2
11 cellular response to gamma radiation GO:0071480 9.57 TP53 MDM2
12 skeletal muscle fiber development GO:0048741 9.56 MYOG MYOD1
13 skeletal muscle tissue regeneration GO:0043403 9.55 MYOG MYOD1
14 negative regulation of cell cycle arrest GO:0071157 9.54 MDM2 CDK4
15 positive regulation of myoblast differentiation GO:0045663 9.52 MYOG MYOD1
16 positive regulation of protein export from nucleus GO:0046827 9.51 TP53 MDM2
17 myoblast differentiation GO:0045445 9.49 MYOG MYOD1
18 cardiac septum morphogenesis GO:0060411 9.46 TP53 MDM2
19 myotube differentiation GO:0014902 9.4 MYOG MYOD1
20 positive regulation of skeletal muscle fiber development GO:0048743 9.37 MYOG MYOD1
21 cellular response to UV-C GO:0071494 9.26 TP53 MDM2
22 muscle cell fate commitment GO:0042693 9.16 MYOG MYOD1
23 cellular response to actinomycin D GO:0072717 8.96 TP53 MDM2
24 positive regulation of muscle cell differentiation GO:0051149 8.8 MYOG MYOD1 MDM2

Molecular functions related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 9.5 TP53 MYOD1 MDM2
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.46 TP53 MYOG MYOD1 MDM2
3 E-box binding GO:0070888 9.37 MYOG MYOD1
4 disordered domain specific binding GO:0097718 9.26 TP53 MDM2
5 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.26 TP53 PEG3 MYOG MYOD1
6 proximal promoter sequence-specific DNA binding GO:0000987 8.8 TP53 MYOG MYOD1

Sources for Undifferentiated Embryonal Sarcoma of the Liver

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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