MCID: UND001
MIFTS: 32

Undifferentiated Embryonal Sarcoma of the Liver

Categories: Liver diseases, Rare diseases, Fetal diseases, Cancer diseases

Aliases & Classifications for Undifferentiated Embryonal Sarcoma of the Liver

MalaCards integrated aliases for Undifferentiated Embryonal Sarcoma of the Liver:

Name: Undifferentiated Embryonal Sarcoma of the Liver 59
Undifferentiated Sarcoma of the Liver 59
Embryonal Sarcoma of the Liver 59
Ues 59

Classifications:

Orphanet: 59  
Rare hepatic diseases


External Ids:

Orphanet 59 ORPHA178315

Summaries for Undifferentiated Embryonal Sarcoma of the Liver

MalaCards based summary : Undifferentiated Embryonal Sarcoma of the Liver, also known as undifferentiated sarcoma of the liver, is related to malignant fibroxanthoma and histiocytoma. An important gene associated with Undifferentiated Embryonal Sarcoma of the Liver is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Regulation of nuclear SMAD2/3 signaling and Bladder cancer. Affiliated tissues include liver, lung and adrenal gland.

Related Diseases for Undifferentiated Embryonal Sarcoma of the Liver

Diseases related to Undifferentiated Embryonal Sarcoma of the Liver via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 malignant fibroxanthoma 28.7 CDK4 MDM2 MYOD1 SERPINA3
2 histiocytoma 28.7 CDK4 MDM2 MYOD1 SERPINA3
3 rhabdomyosarcoma 28.4 CDK4 MDM2 MYOD1 MYOG
4 embryonal sarcoma 27.0 CDK4 MALAT1 MDM2 MYOD1 MYOG PEG3
5 sarcoma 10.9
6 ring chromosome 7 10.5 CDK4 MDM2
7 infiltrating angiolipoma 10.5 CDK4 MDM2
8 spindle cell lipoma 10.5 CDK4 MDM2
9 extraosseous osteosarcoma 10.5 CDK4 MDM2
10 bone osteosarcoma 10.5 CDK4 MDM2
11 lipoblastoma 10.5 CDK4 MDM2
12 mixed liposarcoma 10.5 CDK4 MDM2
13 ischemic fasciitis 10.5 CDK4 MDM2
14 periosteal chondrosarcoma 10.5 CDK4 MDM2
15 atypical lipomatous tumor 10.5 CDK4 MDM2
16 periosteal osteogenic sarcoma 10.5 CDK4 MDM2
17 well-differentiated liposarcoma 10.5 CDK4 MDM2
18 chondroid lipoma 10.4 CDK4 MDM2
19 dedifferentiated liposarcoma 10.4 CDK4 MDM2
20 small cell sarcoma 10.4 CDK4 MDM2
21 infiltrating lipoma 10.4 CDK4 MDM2
22 juxtacortical osteosarcoma 10.4 CDK4 MDM2
23 pleomorphic lipoma 10.4 CDK4 MDM2
24 lipomatosis, multiple 10.4 CDK4 MDM2
25 mesenchymoma 10.4 MDM2 MYOD1
26 peripheral osteosarcoma 10.4 CDK4 MDM2
27 retinal cancer 10.3 CDK4 MDM2
28 sensory system cancer 10.3 CDK4 MDM2
29 ocular cancer 10.2 CDK4 MDM2
30 myxoid liposarcoma 10.2 CDK4 MDM2
31 hepatitis 10.2
32 grade iii astrocytoma 10.1 CDK4 MDM2
33 aging 10.1
34 nervous system cancer 10.1 CDK4 MDM2
35 testicular yolk sac tumor 10.0 MDM2 SERPINA3
36 liposarcoma 10.0 CDK4 MDM2
37 dysphagia 10.0
38 laryngitis 10.0
39 systemic lupus erythematosus 9.9
40 fibrous histiocytoma 9.9
41 hepatoblastoma 9.9
42 appendicitis 9.9
43 lupus erythematosus 9.9
44 malignant fibrous histiocytoma of bone 9.9 CDK4 MDM2 MYOD1
45 melanoma, uveal 9.9 CDK4 MALAT1 MDM2
46 mantle cell lymphoma 9.9 CDK4 MALAT1 MDM2
47 malignant peripheral nerve sheath tumor 9.9 CDK4 MDM2
48 adamantinoma of long bones 9.9 CDK4 MALAT1 MDM2
49 breast rhabdomyosarcoma 9.9 MYOD1 MYOG
50 gallbladder sarcoma 9.9 MYOD1 MYOG

Graphical network of the top 20 diseases related to Undifferentiated Embryonal Sarcoma of the Liver:



Diseases related to Undifferentiated Embryonal Sarcoma of the Liver

Symptoms & Phenotypes for Undifferentiated Embryonal Sarcoma of the Liver

Drugs & Therapeutics for Undifferentiated Embryonal Sarcoma of the Liver

Search Clinical Trials , NIH Clinical Center for Undifferentiated Embryonal Sarcoma of the Liver

Genetic Tests for Undifferentiated Embryonal Sarcoma of the Liver

Anatomical Context for Undifferentiated Embryonal Sarcoma of the Liver

MalaCards organs/tissues related to Undifferentiated Embryonal Sarcoma of the Liver:

41
Liver, Lung, Adrenal Gland, Smooth Muscle, Heart, Brain

Publications for Undifferentiated Embryonal Sarcoma of the Liver

Articles related to Undifferentiated Embryonal Sarcoma of the Liver:

(show top 50) (show all 94)
# Title Authors Year
1
Hanging Undifferentiated Embryonal Sarcoma of the Liver in Adult: an Unusual Presentation of an Aggressive Tumor. ( 29779073 )
2018
2
Undifferentiated Embryonal Sarcoma of the Liver (UESL) in Adolescents: An Unexpected Diagnosis. ( 29702542 )
2018
3
Undifferentiated embryonal sarcoma of the liver in a child: A whole exome sequencing analysis. ( 28539230 )
2017
4
Unresectable Undifferentiated Embryonal Sarcoma of the Liver in an Adult Male Treated with Chemotherapy and Orthotopic Liver Transplantation. ( 29226049 )
2017
5
A case of adult undifferentiated embryonal sarcoma of the liver successfully treated with right trisectionectomy: a case report. ( 28144858 )
2017
6
Undifferentiated embryonal sarcoma of the liver in a young female: treatment with portal vein embolization and liver trisectonectomy. ( 27621753 )
2016
7
A single-center experience with undifferentiated embryonal sarcoma of the liver. ( 27427850 )
2016
8
Undifferentiated Embryonal Sarcoma of the Liver (UESL): A Single-Center Experience and Review of the Literature. ( 26925712 )
2016
9
The Role of Liver Transplantation in Undifferentiated Embryonal Sarcoma of the Liver in Children. ( 27438021 )
2016
10
Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database. ( 27781381 )
2016
11
Undifferentiated embryonal sarcoma of the liver in an adult patient. ( 27377912 )
2016
12
Imaging features of undifferentiated embryonal sarcoma of the liver: a series of 15 children. ( 27562247 )
2016
13
Undifferentiated embryonal sarcoma of the liver with an unusual presentation: case report and review of the literature. ( 27034807 )
2016
14
Repeated hepatic resections and radio-frequency ablations may improve the survival of adult undifferentiated embryonal sarcoma of the liver: report of two cases. ( 26366352 )
2015
15
Undifferentiated embryonal sarcoma of the liver: a concise review. ( 25611111 )
2015
16
Pre-operatively misdiagnosed undifferentiated embryonal sarcoma of the liver: analysis of 16 cases. ( 26807408 )
2015
17
A case of an undifferentiated embryonal sarcoma of the liver mimicking a liver abscess. ( 25364566 )
2014
18
Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: a case report and review of the literature. ( 25603636 )
2014
19
Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver. ( 24762610 )
2014
20
A Rare Case of Childhood Undifferentiated Embryonal Sarcoma of the Liver Managed Successfully. ( 26157829 )
2014
21
Undifferentiated embryonal sarcoma of the liver mistaken for hepatic abscess in an adult. ( 25120683 )
2014
22
Remarkable regression of a lung recurrence from an undifferentiated embryonal sarcoma of the liver treated with a DC vaccine combined with immune cells: a case report. ( 25038546 )
2014
23
Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature. ( 23426588 )
2013
24
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. ( 24073982 )
2013
25
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. ( 24054758 )
2013
26
Characterization of translocations in mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver. ( 24120702 )
2013
27
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. ( 24079623 )
2013
28
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. ( 24210186 )
2013
29
An undifferentiated embryonal sarcoma of the liver containing adipophilin-positive vesicles in an adult with massive sinusoidal invasion. ( 23071865 )
2012
30
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. ( 22551002 )
2012
31
Undifferentiated embryonal sarcoma of the liver in an adult patient: case report. ( 22798120 )
2012
32
Radiologic-pathologic comparison of undifferentiated embryonal sarcoma of the liver in a 61-year-old woman. ( 22421287 )
2012
33
Rare case of adult undifferentiated (embryonal) sarcoma of the liver treated with liver transplantation: excellent long-term survival. ( 25374706 )
2012
34
Undifferentiated embryonal sarcoma of the liver is associated with mesenchymal hamartoma and multiple chromosomal abnormalities: a review of eleven cases. ( 20925497 )
2011
35
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. ( 22146632 )
2011
36
Fine needle aspiration cytology of undifferentiated embryonal sarcoma of the liver. ( 20105209 )
2010
37
Adult primary undifferentiated embryonal sarcoma of the liver: a case report. ( 20137381 )
2010
38
Paradoxical hepatic tumor: Undifferentiated embryonal sarcoma of the liver. ( 20352000 )
2010
39
Primary undifferentiated embryonal sarcoma of the liver mistaken for hydatid disease. ( 20615265 )
2010
40
Diffuse membranous immunoreactivity of CD56 and paranuclear dot-like staining pattern of cytokeratins AE1/3, CAM5.2, and OSCAR in undifferentiated (embryonal) sarcoma of the liver. ( 19809302 )
2010
41
F-18 FDG PET/CT findings in a case of undifferentiated embryonal sarcoma of the liver with lung and adrenal gland metastasis in a child. ( 19352266 )
2009
42
Undifferentiated (embryonal) sarcoma of the liver. ( 19959514 )
2009
43
Undifferentiated (embryonal) sarcoma of the liver: an intriguing diagnosis in a child. ( 19242910 )
2009
44
Diagnosis of undifferentiated embryonal sarcoma of the liver-importance of combined studies of ultrasound and CT scan. ( 19770684 )
2009
45
Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. ( 19278169 )
2009
46
Undifferentiated embryonal sarcoma of the liver. ( 18356418 )
2008
47
Undifferentiated embryonal sarcoma of the liver in a child complicated by haemorrhage. ( 18688607 )
2008
48
Undifferentiated embryonal sarcoma of the liver: case report and literature survey. ( 18836810 )
2008
49
Undifferentiated embryonal sarcoma of the liver in adults. ( 18361435 )
2008
50
Undifferentiated embryonal sarcoma of the liver in adult. ( 18374056 )
2008

Variations for Undifferentiated Embryonal Sarcoma of the Liver

Expression for Undifferentiated Embryonal Sarcoma of the Liver

Search GEO for disease gene expression data for Undifferentiated Embryonal Sarcoma of the Liver.

Pathways for Undifferentiated Embryonal Sarcoma of the Liver

Pathways related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 CDK4 MYOD1
2 11.23 CDK4 MDM2
3
Show member pathways
11.09 MYOD1 MYOG
4 11 MDM2 MYOD1
5 10.82 CDK4 MDM2
6 10.6 CDK4 MDM2
7 10.13 CDK4 MDM2

GO Terms for Undifferentiated Embryonal Sarcoma of the Liver

Cellular components related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 CDK4 MYOD1 MYOG

Biological processes related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cellular response to growth factor stimulus GO:0071363 9.55 MDM2 MYOG
2 skeletal muscle tissue development GO:0007519 9.54 MYOD1 MYOG
3 skeletal muscle cell differentiation GO:0035914 9.52 MYOD1 MYOG
4 positive regulation of cell cycle GO:0045787 9.51 CDK4 MDM2
5 cellular response to estradiol stimulus GO:0071392 9.49 MYOD1 MYOG
6 skeletal muscle fiber development GO:0048741 9.48 MYOD1 MYOG
7 positive regulation of muscle cell differentiation GO:0051149 9.46 MYOD1 MYOG
8 negative regulation of cell cycle arrest GO:0071157 9.43 CDK4 MDM2
9 positive regulation of myoblast differentiation GO:0045663 9.4 MYOD1 MYOG
10 myoblast differentiation GO:0045445 9.37 MYOD1 MYOG
11 positive regulation of myoblast fusion GO:1901741 9.32 MYOD1 MYOG
12 myotube differentiation GO:0014902 9.26 MYOD1 MYOG
13 positive regulation of skeletal muscle fiber development GO:0048743 9.16 MYOD1 MYOG
14 muscle cell fate commitment GO:0042693 8.96 MYOD1 MYOG
15 regulation of gene expression GO:0010468 8.92 CDK4 MDM2 MYOD1 PEG3

Molecular functions related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.26 MYOD1 MYOG
2 core promoter binding GO:0001047 9.16 MYOD1 MYOG
3 chromatin DNA binding GO:0031490 8.96 MYOD1 MYOG
4 E-box binding GO:0070888 8.62 MYOD1 MYOG

Sources for Undifferentiated Embryonal Sarcoma of the Liver

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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