UES
MCID: UND001
MIFTS: 33

Undifferentiated Embryonal Sarcoma of the Liver (UES)

Categories: Cancer diseases, Fetal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Undifferentiated Embryonal Sarcoma of the Liver

MalaCards integrated aliases for Undifferentiated Embryonal Sarcoma of the Liver:

Name: Undifferentiated Embryonal Sarcoma of the Liver 59
Undifferentiated Sarcoma of the Liver 59
Embryonal Sarcoma of the Liver 59
Ues 59

Classifications:

Orphanet: 59  
Rare hepatic diseases


External Ids:

Orphanet 59 ORPHA178315

Summaries for Undifferentiated Embryonal Sarcoma of the Liver

MalaCards based summary : Undifferentiated Embryonal Sarcoma of the Liver, also known as undifferentiated sarcoma of the liver, is related to embryonal sarcoma and histiocytoma. An important gene associated with Undifferentiated Embryonal Sarcoma of the Liver is CDK4 (Cyclin Dependent Kinase 4), and among its related pathways/superpathways are Regulation of nuclear SMAD2/3 signaling and Bladder cancer. The drugs Arranon and Beleodaq have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain.

Related Diseases for Undifferentiated Embryonal Sarcoma of the Liver

Diseases related to Undifferentiated Embryonal Sarcoma of the Liver via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 embryonal sarcoma 30.2 CDK4 MALAT1 MDM2 MYOD1 MYOG PEG3
2 histiocytoma 30.0 MDM2 MYOD1 SERPINA3
3 rhabdomyosarcoma 29.8 CDK4 MDM2 MYOD1 MYOG
4 malignant fibroxanthoma 29.8 CDK4 MDM2 MYOD1 SERPINA3
5 sarcoma 11.1
6 spindle cell sarcoma 10.3
7 liposarcoma 10.2 CDK4 MDM2
8 laryngitis 10.1
9 dysphagia 10.1
10 ring chromosome 7 10.1 CDK4 MDM2
11 mesenchymoma 10.1 MDM2 MYOD1
12 infiltrating angiolipoma 10.1 CDK4 MDM2
13 spindle cell lipoma 10.1 CDK4 MDM2
14 cellular myxoid liposarcoma 10.1 CDK4 MDM2
15 myxoid liposarcoma 10.1 CDK4 MDM2
16 lipoblastoma 10.1 CDK4 MDM2
17 bone osteosarcoma 10.1 CDK4 MDM2
18 atypical lipomatous tumor 10.1 CDK4 MDM2
19 mixed liposarcoma 10.1 CDK4 MDM2
20 periosteal chondrosarcoma 10.1 CDK4 MDM2
21 chondroid lipoma 10.1 CDK4 MDM2
22 periosteal osteogenic sarcoma 10.1 CDK4 MDM2
23 ischemic fasciitis 10.1 CDK4 MDM2
24 well-differentiated liposarcoma 10.1 CDK4 MDM2
25 dedifferentiated liposarcoma 10.1 CDK4 MDM2
26 small cell sarcoma 10.1 CDK4 MDM2
27 breast rhabdomyosarcoma 10.1 MYOD1 MYOG
28 infiltrating lipoma 10.1 CDK4 MDM2
29 gallbladder sarcoma 10.1 MYOD1 MYOG
30 juxtacortical osteosarcoma 10.1 CDK4 MDM2
31 peripheral osteosarcoma 10.1 CDK4 MDM2
32 inflammatory leiomyosarcoma 10.1 MYOD1 MYOG
33 conventional leiomyosarcoma 10.1 MYOD1 MYOG
34 lipomatosis, multiple 10.1 CDK4 MDM2
35 adult fibrosarcoma 10.1 MYOD1 MYOG
36 retinal cancer 10.1 CDK4 MDM2
37 systemic lupus erythematosus 10.1
38 fibrous histiocytoma 10.1
39 appendicitis 10.1
40 lupus erythematosus 10.1
41 medullomyoblastoma 10.1 MYOD1 MYOG
42 nephrogenic adenofibroma 10.0 MYOD1 MYOG
43 ocular cancer 10.0 CDK4 MDM2
44 extraosseous ewing's sarcoma 10.0 MYOD1 MYOG
45 grade iii astrocytoma 10.0 CDK4 MDM2
46 embryonal rhabdomyosarcoma 10.0 MYOD1 MYOG
47 inflammatory myofibroblastic tumor 10.0 CDK4 MDM2
48 malignant fibrous histiocytoma of bone 10.0 CDK4 MDM2 MYOD1
49 schizencephaly 10.0
50 pemphigus foliaceus 10.0

Graphical network of the top 20 diseases related to Undifferentiated Embryonal Sarcoma of the Liver:



Diseases related to Undifferentiated Embryonal Sarcoma of the Liver

Symptoms & Phenotypes for Undifferentiated Embryonal Sarcoma of the Liver

Drugs & Therapeutics for Undifferentiated Embryonal Sarcoma of the Liver

FDA approved drugs:

(show all 33)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Arranon 18 49 NELARABINE GlaxoSmithKline October 2005
2
Beleodaq 18 49 BELINOSTAT Spectrum Pharmaceuticals July 2014
3
Campath 18 49 ALEMTUZUMAB Berlex Laboratories May 2001
4
Eloxatin 18 49 OXALIPLATIN Sanofi-aventis August 2002
5
Evista 18 49 RALOXIFENE HYDROCHLORIDE Eli Lilly September 2007
6
Farydak 18 49 PANOBINOSTAT LACTATE Novartis February 2015
7
Femara 18 49 LETROZOLE Novartis January 2001
8
Feridex I.V. 18 FERUMOXIDES Advanced Magnetics February 1996
9
Fusilev 18 LEVOLEUCOVORIN CALCIUM Spectrum Pharmaceuticals March of 2008
10
Halaven 18 49 ERIBULIN MESYLATE Eisai November 2010
11
Iressa 18 49 GEFITINIB AstraZeneca May 2003
12
Istodax 18 49 ROMIDEPSIN Gloucester Pharmaceuticals November 2009
13
Jevtana 18 49 CABAZITAXEL sanofi aventis June 2010
14
Nolvadex 18 49 TAMOXIFEN CITRATE AstraZeneca October 1998
15
Synercid I.V. 18 DALFOPRISTIN; QUINUPRISTIN QUINUPRISTIN; DALFOPRISTIN Rhone Poulenc Rorer September 1999
16
Trelstar Depot/ Trelstar LA 18 TRIPTORELIN PAMOATE Debio Rechereche Pharmaceutique, Target Research Associates/ Debiopharm June 2000/ June 2001
17
Trisenox 18 49 ARSENIC TRIOXIDE Cell Therapeutics September 2000
18
UroXatral 18 ALFUZOSIN HYDROCHLORIDE Sanofi-aventis June 2003
19
Vandetanib 18 49 vandetanib AstraZeneca April 2011
20
Visipaque (270 &320) 18 IODIXANOL Nycomed April 1996
21
Votrient 18 49 PAZOPANIB HYDROCHLORIDE GlaxoSmithKline April 2012/ October of 2009
22
Zytiga 18 49 ABIRATERONE ACETATE Centocor Ortho Biotech May 2011
23
Aldurazyme 18 LARONIDASE Genzyme May 2003
24
Anoro Ellipta 18 UMECLIDINIUM BROMIDE; VILANTEROL TRIFENATATE GlaxoSmithKline December of 2013
25
Azmacort 18 TRIAMCINOLONE ACETONIDE Rhone Poulenc Rorer November 1996
26
Breo Ellipta 18 FLUTICASONE FUROATE; VILANTEROL TRIFENATATE GlaxoSmithKline May 2013
27
Dulera 18 FORMOTEROL FUMARATE; MOMETASONE FUROATE Merck June 2010
28
Incruse Ellipta 18 UMECLIDINIUM BROMIDE GlaxoSmithKline May 2014
29
Patanase 18 OLOPATADINE HYDROCHLORIDE Alcon April 2008
30
Spiriva HandiHaler 18 TIOTROPIUM BROMIDE Boehringer Ingelheim February 2004
31
Tygacil 18 TIGECYCLINE Wyeth 2005
32
Visipaque 18 IODIXANOL Nycomed April 1996
33
Zyflo 18 ZILEUTON Abbott Laboratories January 1997

Search Clinical Trials , NIH Clinical Center for Undifferentiated Embryonal Sarcoma of the Liver

Genetic Tests for Undifferentiated Embryonal Sarcoma of the Liver

Anatomical Context for Undifferentiated Embryonal Sarcoma of the Liver

MalaCards organs/tissues related to Undifferentiated Embryonal Sarcoma of the Liver:

41
Liver, Lung, Brain, Kidney, Bone, Prostate, Skeletal Muscle

Publications for Undifferentiated Embryonal Sarcoma of the Liver

Articles related to Undifferentiated Embryonal Sarcoma of the Liver:

(show top 50) (show all 98)
# Title Authors Year
1
Hanging Undifferentiated Embryonal Sarcoma of the Liver in Adult: an Unusual Presentation of an Aggressive Tumor. ( 29779073 )
2018
2
Undifferentiated Embryonal Sarcoma of the Liver (UESL) in Adolescents: An Unexpected Diagnosis. ( 29702542 )
2018
3
Undifferentiated embryonal sarcoma of the liver in adult patient: A report of two cases. ( 30215049 )
2018
4
Pulmonary Metastases from an Undifferentiated Embryonal Sarcoma of the Liver: A Case Report and Review. ( 30254779 )
2018
5
Undifferentiated Embryonal Sarcoma of the Liver in an Adult Patient. ( 30258736 )
2018
6
Undifferentiated embryonal sarcoma of the liver in a child: A whole exome sequencing analysis. ( 28539230 )
2017
7
Unresectable Undifferentiated Embryonal Sarcoma of the Liver in an Adult Male Treated with Chemotherapy and Orthotopic Liver Transplantation. ( 29226049 )
2017
8
A case of adult undifferentiated embryonal sarcoma of the liver successfully treated with right trisectionectomy: a case report. ( 28144858 )
2017
9
Undifferentiated embryonal sarcoma of the liver in a young female: treatment with portal vein embolization and liver trisectonectomy. ( 27621753 )
2016
10
A single-center experience with undifferentiated embryonal sarcoma of the liver. ( 27427850 )
2016
11
Undifferentiated Embryonal Sarcoma of the Liver (UESL): A Single-Center Experience and Review of the Literature. ( 26925712 )
2016
12
The Role of Liver Transplantation in Undifferentiated Embryonal Sarcoma of the Liver in Children. ( 27438021 )
2016
13
Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database. ( 27781381 )
2016
14
Undifferentiated embryonal sarcoma of the liver in an adult patient. ( 27377912 )
2016
15
Imaging features of undifferentiated embryonal sarcoma of the liver: a series of 15 children. ( 27562247 )
2016
16
Undifferentiated embryonal sarcoma of the liver with an unusual presentation: case report and review of the literature. ( 27034807 )
2016
17
Repeated hepatic resections and radio-frequency ablations may improve the survival of adult undifferentiated embryonal sarcoma of the liver: report of two cases. ( 26366352 )
2015
18
Undifferentiated embryonal sarcoma of the liver: a concise review. ( 25611111 )
2015
19
Pre-operatively misdiagnosed undifferentiated embryonal sarcoma of the liver: analysis of 16 cases. ( 26807408 )
2015
20
A case of an undifferentiated embryonal sarcoma of the liver mimicking a liver abscess. ( 25364566 )
2014
21
Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: a case report and review of the literature. ( 25603636 )
2014
22
Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver. ( 24762610 )
2014
23
A Rare Case of Childhood Undifferentiated Embryonal Sarcoma of the Liver Managed Successfully. ( 26157829 )
2014
24
Undifferentiated embryonal sarcoma of the liver mistaken for hepatic abscess in an adult. ( 25120683 )
2014
25
Remarkable regression of a lung recurrence from an undifferentiated embryonal sarcoma of the liver treated with a DC vaccine combined with immune cells: a case report. ( 25038546 )
2014
26
Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature. ( 23426588 )
2013
27
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. ( 24073982 )
2013
28
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. ( 24054758 )
2013
29
Characterization of translocations in mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver. ( 24120702 )
2013
30
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. ( 24079623 )
2013
31
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. ( 24210186 )
2013
32
An undifferentiated embryonal sarcoma of the liver containing adipophilin-positive vesicles in an adult with massive sinusoidal invasion. ( 23071865 )
2012
33
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. ( 22551002 )
2012
34
Undifferentiated embryonal sarcoma of the liver in an adult patient: case report. ( 22798120 )
2012
35
Radiologic-pathologic comparison of undifferentiated embryonal sarcoma of the liver in a 61-year-old woman. ( 22421287 )
2012
36
Rare case of adult undifferentiated (embryonal) sarcoma of the liver treated with liver transplantation: excellent long-term survival. ( 25374706 )
2012
37
Undifferentiated embryonal sarcoma of the liver is associated with mesenchymal hamartoma and multiple chromosomal abnormalities: a review of eleven cases. ( 20925497 )
2011
38
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. ( 22146632 )
2011
39
Fine needle aspiration cytology of undifferentiated embryonal sarcoma of the liver. ( 20105209 )
2010
40
Adult primary undifferentiated embryonal sarcoma of the liver: a case report. ( 20137381 )
2010
41
Paradoxical hepatic tumor: Undifferentiated embryonal sarcoma of the liver. ( 20352000 )
2010
42
Primary undifferentiated embryonal sarcoma of the liver mistaken for hydatid disease. ( 20615265 )
2010
43
Diffuse membranous immunoreactivity of CD56 and paranuclear dot-like staining pattern of cytokeratins AE1/3, CAM5.2, and OSCAR in undifferentiated (embryonal) sarcoma of the liver. ( 19809302 )
2010
44
F-18 FDG PET/CT findings in a case of undifferentiated embryonal sarcoma of the liver with lung and adrenal gland metastasis in a child. ( 19352266 )
2009
45
Undifferentiated (embryonal) sarcoma of the liver. ( 19959514 )
2009
46
Undifferentiated (embryonal) sarcoma of the liver: an intriguing diagnosis in a child. ( 19242910 )
2009
47
Diagnosis of undifferentiated embryonal sarcoma of the liver-importance of combined studies of ultrasound and CT scan. ( 19770684 )
2009
48
Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. ( 19278169 )
2009
49
Undifferentiated embryonal sarcoma of the liver. ( 18356418 )
2008
50
Undifferentiated embryonal sarcoma of the liver in a child complicated by haemorrhage. ( 18688607 )
2008

Variations for Undifferentiated Embryonal Sarcoma of the Liver

Expression for Undifferentiated Embryonal Sarcoma of the Liver

Search GEO for disease gene expression data for Undifferentiated Embryonal Sarcoma of the Liver.

Pathways for Undifferentiated Embryonal Sarcoma of the Liver

Pathways related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 CDK4 MYOD1
2 11.23 CDK4 MDM2
3
Show member pathways
11.09 MYOD1 MYOG
4 11 MDM2 MYOD1
5 10.82 CDK4 MDM2
6 10.6 CDK4 MDM2
7 10.13 CDK4 MDM2

GO Terms for Undifferentiated Embryonal Sarcoma of the Liver

Cellular components related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 CDK4 MYOD1 MYOG

Biological processes related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cellular response to growth factor stimulus GO:0071363 9.55 MDM2 MYOG
2 positive regulation of cell cycle GO:0045787 9.54 CDK4 MDM2
3 skeletal muscle tissue development GO:0007519 9.52 MYOD1 MYOG
4 skeletal muscle cell differentiation GO:0035914 9.51 MYOD1 MYOG
5 cellular response to estradiol stimulus GO:0071392 9.49 MYOD1 MYOG
6 positive regulation of muscle cell differentiation GO:0051149 9.48 MYOD1 MYOG
7 skeletal muscle fiber development GO:0048741 9.46 MYOD1 MYOG
8 negative regulation of cell cycle arrest GO:0071157 9.43 CDK4 MDM2
9 positive regulation of myoblast differentiation GO:0045663 9.4 MYOD1 MYOG
10 myoblast differentiation GO:0045445 9.37 MYOD1 MYOG
11 positive regulation of myoblast fusion GO:1901741 9.32 MYOD1 MYOG
12 myotube differentiation GO:0014902 9.26 MYOD1 MYOG
13 positive regulation of skeletal muscle fiber development GO:0048743 9.16 MYOD1 MYOG
14 muscle cell fate commitment GO:0042693 8.96 MYOD1 MYOG
15 regulation of gene expression GO:0010468 8.92 CDK4 MDM2 MYOD1 PEG3

Molecular functions related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.16 MYOD1 MYOG
2 chromatin DNA binding GO:0031490 8.96 MYOD1 MYOG
3 E-box binding GO:0070888 8.62 MYOD1 MYOG

Sources for Undifferentiated Embryonal Sarcoma of the Liver

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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