MCID: UNC014
MIFTS: 22

Unicentric Castleman Disease

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Unicentric Castleman Disease

MalaCards integrated aliases for Unicentric Castleman Disease:

Name: Unicentric Castleman Disease 20 58
Localized Castleman Disease 20 58
Unicentric Angiofollicular Ganglionic Hyperplasia 20
Localized Angiofollicular Lymphoid Hyperplasia 70
Unicentric Angiofollicular Lymph Hyperplasia 20
Angiolymphoid Hyperplasia 70

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 D47.7
Orphanet 58 ORPHA93685
UMLS 70 C0017531 C3898582

Summaries for Unicentric Castleman Disease

GARD : 20 Unicentric Castleman disease (UCD) is a rare condition that affects the lymph nodes and related tissues. It is a form of Castleman disease that is "localized" to a single set of lymph nodes (as opposed to multicentric Castleman disease which has more widespread effects). UCD often starts as an enlarged lymph node. Depending on the location of this enlarged node, some people will have no additional features of the condition, while others will develop symptoms when it pushes on nearby organs and/or tissues. The exact underlying cause of UCD is currently unknown. Treatment typically includes surgical removal of the affected lymph node.

MalaCards based summary : Unicentric Castleman Disease, also known as localized castleman disease, is related to castleman disease and multicentric castleman disease. An important gene associated with Unicentric Castleman Disease is PDGFRB (Platelet Derived Growth Factor Receptor Beta). Affiliated tissues include lymph node, pancreas and prostate.

Wikipedia : 73 Unicentric Castleman disease is a subtype of Castleman disease (also known as giant lymph node... more...

Related Diseases for Unicentric Castleman Disease

Graphical network of the top 20 diseases related to Unicentric Castleman Disease:



Diseases related to Unicentric Castleman Disease

Symptoms & Phenotypes for Unicentric Castleman Disease

Drugs & Therapeutics for Unicentric Castleman Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Epithelioid Hemangioma of Bone And Soft Tissue: a Benign Tumor With Metastatic Potential Completed NCT03169595

Search NIH Clinical Center for Unicentric Castleman Disease

Inferred drug relations via UMLS 70 / NDF-RT 51 :


siltuximab

Genetic Tests for Unicentric Castleman Disease

Anatomical Context for Unicentric Castleman Disease

MalaCards organs/tissues related to Unicentric Castleman Disease:

40
Lymph Node, Pancreas, Prostate, Tonsil, Bone, Brain, Lung

Publications for Unicentric Castleman Disease

Articles related to Unicentric Castleman Disease:

(show top 50) (show all 87)
# Title Authors PMID Year
1
A 10-year observational single-center study of retroperitoneal unicentric Castleman disease. 61
33725899 2021
2
Unicentric Castleman Disease; the laparoscopic en bloc resection of a hypervascular Giant Lymph Node in the aortacaval zone. 61
33631872 2021
3
Author Correction: The value of multiparameter 18F-FDG PET/CT imaging in differentiating retroperitoneal paragangliomas from unicentric Castleman disease. 61
33623136 2021
4
Autoimmunity Due to Unicentric Castleman Disease Cured by Resection of a Hepatic Mass. 61
31609813 2021
5
UCD with MCD-like inflammatory state: surgical excision is highly effective. 61
33570636 2021
6
International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease. 61
33284946 2020
7
Multicentric Plasma-Cell Type Castleman Disease Masquerading As Hodgkin Lymphoma: A Case Report. 61
33268942 2020
8
Pediatric Unicentric Castleman Disease of the Temporalis Muscle. 61
32790828 2020
9
The value of multiparameter 18F-FDG PET/CT imaging in differentiating retroperitoneal paragangliomas from unicentric Castleman disease. 61
32732920 2020
10
Retroperitoneal Castleman Disease Invading Iliac Vein and Inferior Vena Cava Treated by Tumorectomy with Vascular Repair: A Case Report. 61
31917225 2020
11
Abdominal Mass Caused Failure to Thrive in a Young Boy: Mixed-Type Localized Retroperitoneal Castleman Disease. 61
32884530 2020
12
Unicentric Castleman Disease Mimicking an Autoinflammatory Disorder: A Diagnostic Challenge in a Pediatric Patient With Recurrent Fever. 61
31335823 2020
13
Clinicopathological Profile of Castleman's Disease in Indian Population: Experience From a Tertiary Care Center. 61
32425374 2020
14
A CARE-compliant article: Unicentric Castleman disease presenting as a retroperitoneal mass of the upper edge of the pancreas: A case report. 61
32176100 2020
15
Castleman Disease of the Parotid Gland: A Case Report. 61
31837286 2020
16
[Clinical analysis of 30 cases of Castleman disease with different types of thoracic involvement]. 61
32135633 2020
17
Unicentric Castleman disease, hyaline vascular variant, stromal rich, with increased plasma cells and a high level of serum IL-6: Raising the diagnostic and therapeutic issues. 61
31630065 2019
18
Epidemiological analysis of multicentric and unicentric Castleman disease and TAFRO syndrome in Japan. 61
31708515 2019
19
Unicentric Castleman disease in the lesser omentum: A case report. 61
31350088 2019
20
Treatment of multicentric Castleman disease through combination of tocilizumab, lenalidomide and glucocorticoids: Case report. 61
31725610 2019
21
Treatment and outcome of Unicentric Castleman Disease: a retrospective analysis of 71 cases. 61
31016730 2019
22
Hyaline vascular variant of unicentric Castleman disease of the tonsil: a case report. 61
31253137 2019
23
Recurrent PDGFRB mutations in unicentric Castleman disease. 61
30607019 2019
24
Hyaline vascular-type unicentric Castleman disease presenting as a subcutaneous nodule in a child. 61
30156317 2019
25
[Indolent T-lymphoblastic proliferation in association with localized Castleman disease: A case report]. 61
30554835 2019
26
Development of Castleman Disease in the Paravertebral Space Mimicking a Neurogenic Tumor. 61
30834220 2019
27
Radiologic and Histopathologic Features in an Intracranial Localized Castleman Disease: A Case Report and Review of Literature. 61
30586033 2019
28
Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report. 61
31113603 2019
29
A Case of Unicentric Castleman Disease and Langerhans Cell Histiocytosis: Two Entities in One Lymph Node. 61
30549992 2018
30
ADA2 Deficiency Mimicking Idiopathic Multicentric Castleman Disease. 61
30139808 2018
31
Unicentric Castleman disease presenting as a retroperitoneal peripancreatic mass: A report of two cases and review of literature. 61
30228787 2018
32
Analysis of clinical characteristics and prognosis factors of 71 cases with HIV-negative Castleman's disease: hypoproteinemia is an unfavorable prognostic factor which should be treated appropriately. 61
29736622 2018
33
Next-generation sequencing of idiopathic multicentric and unicentric Castleman disease and follicular dendritic cell sarcomas. 61
29496669 2018
34
Unicentric Castleman Disease. 61
29157620 2018
35
Is tocilizumab a potential therapeutic option for refractory unicentric Castleman disease? 61
28401573 2018
36
Epidemiology of Castleman Disease. 61
29157611 2018
37
Rare finding in peripheral nerve surgery: an unicentric Castleman disease presenting as median nerve tumour. 61
30397634 2018
38
Castleman disease: Case series of two surgical patients from different ends of the disease spectrum with literature review. 61
30399511 2018
39
Unicentric castleman disease complicated by paraneoplastic bronchiolitis obliterans and pemphigus. 61
30128272 2018
40
Resection of unicentric interlobar Castleman disease with following adjuvant radiotherapy. 61
29225882 2017
41
Castleman Disease Presenting as an Abdominal Mass. 61
28584844 2017
42
Hodgkin Lymphoma and Castleman Disease: When One Blood Disease Can Hide Another. 61
28197347 2017
43
Castleman Disease of the Thorax: Clinical, Radiologic, and Pathologic Correlation: From the Radiologic Pathology Archives. 61
27618318 2016
44
Unicentric Castleman Disease: An Unusual Cause of An Isolated Neck Mass. 61
27660550 2016
45
Perivesical unicentric Castleman disease initially suspected to be metastatic prostate cancer. 61
27141204 2016
46
Complete resection of unicentric Castleman disease in the superior mediastinum: A case report. 61
27318017 2016
47
Update and new approaches in the treatment of Castleman disease. 61
27536166 2016
48
Sonographic findings of localized Castleman disease of the abdomen and pelvis. 61
25346169 2015
49
Exuberant cortical thymocyte proliferation mimicking T-lymphoblastic lymphoma within recurrent large inguinal lymph node masses of localized Castleman disease. 61
25953658 2015
50
Case Report Unicentric Castleman disease located in the anterior mediastinum misdiagnosed as invasive thymoma: a case report. 61
26125875 2015

Variations for Unicentric Castleman Disease

Expression for Unicentric Castleman Disease

Search GEO for disease gene expression data for Unicentric Castleman Disease.

Pathways for Unicentric Castleman Disease

GO Terms for Unicentric Castleman Disease

Sources for Unicentric Castleman Disease

3 CDC
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45 MESH via Orphanet
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49 NCI
50 NCIt
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56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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