MCID: UNL002
MIFTS: 33

Unilateral Retinoblastoma

Categories: Neuronal diseases, Cancer diseases, Eye diseases

Aliases & Classifications for Unilateral Retinoblastoma

MalaCards integrated aliases for Unilateral Retinoblastoma:

Name: Unilateral Retinoblastoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4651
NCIt 50 C8714
UMLS 73 C0854915

Summaries for Unilateral Retinoblastoma

Disease Ontology : 12 A retinoblastoma that effects only one eye.

MalaCards based summary : Unilateral Retinoblastoma is related to bilateral retinoblastoma and retinoblastoma. An important gene associated with Unilateral Retinoblastoma is RB1 (RB Transcriptional Corepressor 1), and among its related pathways/superpathways are Mitotic G1-G1/S phases and Adipogenesis. The drugs Etoposide and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include eye, pineal and testes.

Related Diseases for Unilateral Retinoblastoma

Diseases related to Unilateral Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 bilateral retinoblastoma 29.6 RB1 RBL1
2 retinoblastoma 10.6
3 aging 10.0
4 retinal cancer 10.0 RB1 RBL1
5 sensory system cancer 9.9 RB1 RBL1
6 intraocular retinoblastoma 9.9 GREM2 RBL1
7 ocular cancer 9.8 RB1 RBL1
8 pineoblastoma 9.8
9 teratoma 9.8
10 retinitis 9.8
11 ewing's family of tumors 9.8
12 neuroblastoma 9.6
13 peters-plus syndrome 9.6
14 nasopharyngitis 9.6
15 sarcoma 9.6
16 leydig cell tumor 9.6
17 rhabdomyosarcoma 9.6
18 cerebritis 9.6
19 mature teratoma 9.6
20 ovarian germ cell teratoma 9.6
21 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.6
22 nervous system cancer 9.6 RB1 RBL1

Graphical network of the top 20 diseases related to Unilateral Retinoblastoma:



Diseases related to Unilateral Retinoblastoma

Symptoms & Phenotypes for Unilateral Retinoblastoma

Drugs & Therapeutics for Unilateral Retinoblastoma

Drugs for Unilateral Retinoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
2
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
3
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
4
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
5
Mesna Approved, Investigational Phase 3,Phase 2 3375-50-6 598
6
Topotecan Approved, Investigational Phase 3,Phase 2 119413-54-6, 123948-87-8 60700
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
8
Doxil Approved June 1999 Phase 3,Phase 2 31703
9 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
10 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
11 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
12 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
13 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
14 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable
15 topoisomerase I inhibitors Phase 3,Phase 2
16 Anti-Bacterial Agents Phase 3,Phase 2
17 Antibiotics, Antitubercular Phase 3,Phase 2
18 Antirheumatic Agents Phase 3,Phase 2
19 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Not Applicable
20 Anesthetics Phase 3,Phase 2
21
Lenograstim Approved, Investigational Phase 2 135968-09-1
22
Menthol Approved Phase 2 2216-51-5 16666
23
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
24 Adjuvants, Immunologic Phase 2
25
Melphalan Approved Phase 1,Not Applicable 148-82-3 4053 460612
26
Cytarabine Approved, Investigational Not Applicable 147-94-4 6253
27
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
28 Anti-Infective Agents Not Applicable
29 Antimetabolites Not Applicable
30 Antiviral Agents Not Applicable
31 Antimetabolites, Antineoplastic Not Applicable
32 Nitrogen Mustard Compounds Not Applicable
33 phenylalanine Nutraceutical Not Applicable
34 alanine Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vincristine, Carboplatin, and Etoposide or Observation Only in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Retinoblastoma Completed NCT00335738 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
2 Treatment Protocol for Non-Metastatic Unilateral Retinoblastoma Recruiting NCT03475121 Phase 3
3 Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine + Topotecan;Vincristine + Carboplatin + Etoposide;Vincristine + Cyclophosphamide + Doxorubicin;Vincristine+Carboplatin+Etoposide
4 Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009) Recruiting NCT02870907 Phase 2 Etoposide;Vincristine;Carboplatin;Vincristine;Cyclophosphamide;Carboplatin;Etoposide;Carboplatin;Thiotepa;Vincristine;Cyclophosphamide;Carboplatin;Etoposide;Thiotepa
5 Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma Recruiting NCT01783535 Phase 2 vincristine;topotecan;filgrastim;PEG-filgrastim;carboplatin;etoposide;cyclophosphamide;MESNA;doxorubicin
6 Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma Terminated NCT00432445 Phase 2
7 Alternating Systemic Chemotherapy and Intra-Arterial Melphalan Chemotherapy in Children With Intra-Ocular Retinoblastoma Active, not recruiting NCT02116959 Phase 1 Melphalan;Carboplatin;Etoposide;Vincristine
8 Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye Unknown status NCT00360750 Not Applicable carboplatin;cytarabine;etoposide;vincristine sulfate
9 Intra-arterial Melphalan in Treating Younger Patients With Unilateral Retinoblastoma Active, not recruiting NCT02097134 Not Applicable Melphalan

Search NIH Clinical Center for Unilateral Retinoblastoma

Genetic Tests for Unilateral Retinoblastoma

Anatomical Context for Unilateral Retinoblastoma

MalaCards organs/tissues related to Unilateral Retinoblastoma:

41
Eye, Pineal, Testes

Publications for Unilateral Retinoblastoma

Articles related to Unilateral Retinoblastoma:

(show top 50) (show all 74)
# Title Authors Year
1
Treatment of Nonmetastatic Unilateral Retinoblastoma in Children. ( 29799944 )
2018
2
Mature Ovarian Teratoma After Treatment for Unilateral Retinoblastoma With Nonmutated RB1. ( 28719514 )
2017
3
Second Primary Rhabdomyosarcoma in Nonhereditary Unilateral Retinoblastoma Not Treated with Radiotherapy. ( 28682022 )
2017
4
Giant retinal tear after intra-arterial chemotherapy for advanced unilateral retinoblastoma. ( 28815057 )
2017
5
MONTE CARLO SIMULATION OF OUT-OF-FIELD ORGAN DOSES AND CANCER RISK IN TANZANIA FOR RADIATION THERAPY OF UNILATERAL RETINOBLASTOMA USING A 60Co UNIT. ( 29216393 )
2017
6
Lack of correlation between age at diagnosis and RB1 mutations for unilateral retinoblastoma: the importance of genetic testing. ( 29286867 )
2017
7
Advanced unilateral retinoblastoma: a case of sparing enucleation treatment failure. ( 27085272 )
2016
8
Unilateral Retinoblastoma Managed With Intravenous Chemotherapy Versus Intra-Arterial Chemotherapy. Outcomes Based on the International Classification of Retinoblastoma. ( 26765038 )
2016
9
Mutation spectrum of RB1 gene in unilateral retinoblastoma cases from Tunisia and correlations with clinical features. ( 25602518 )
2015
10
Uncommon RB1 somatic mutations in a unilateral retinoblastoma patient. ( 26117602 )
2015
11
Advanced Unilateral Retinoblastoma: The Impact of Ophthalmic Artery Chemosurgery on Enucleation Rate and Patient Survival at MSKCC. ( 26709699 )
2015
12
Maternal diet during pregnancy and unilateral retinoblastoma. ( 25542139 )
2015
13
Clinical treatment and prognostic observation for different pathological infiltrations in 537 patients with unilateral retinoblastoma. ( 25316233 )
2014
14
From a Suspicious Cystic Pineal Gland to Pineoblastoma in a Patient with Familial Unilateral Retinoblastoma. ( 24940935 )
2014
15
Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation. ( 24577551 )
2014
16
Sporadic unilateral retinoblastoma or first sign of bilateral disease? ( 23355526 )
2013
17
Multiple atypical recurrent meningiomas 13 years after radiotherapy for unilateral retinoblastoma: case report and review of the literature. ( 23487298 )
2013
18
Results of a multicenter prospective study on the postoperative treatment of unilateral retinoblastoma after primary enucleation. ( 23460706 )
2013
19
A 20.5-Mb germline deletion of 13q13.1-->q14.3 and somatic mutations of the RB1 gene in an 8-year-old girl with unilateral retinoblastoma, developmental delay and mental retardation. ( 22303805 )
2011
20
Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding. ( 22174572 )
2011
21
Ewing's sarcoma as second malignancy following a short latency in unilateral retinoblastoma. ( 21826516 )
2011
22
Unilateral retinoblastoma in an eye with Peters anomaly. ( 20451864 )
2010
23
Results of a prospective study for the treatment of unilateral retinoblastoma. ( 20486172 )
2010
24
Some clinical findings at presentation can predict high-risk pathology features in unilateral retinoblastoma. ( 19415010 )
2009
25
Management and outcome of unilateral retinoblastoma. ( 20006813 )
2009
26
Molecular karyotype of sporadic unilateral retinoblastoma tumors. ( 19491728 )
2009
27
Ki-67 cell proliferation in familial and in esporadic unilateral retinoblastoma: case report. ( 17589712 )
2007
28
Comparison of orbital volumes in enucleated patients with unilateral retinoblastoma: hydroxyapatite implants versus silicone implants. ( 17881992 )
2007
29
Unilateral retinoblastoma, lack of familial history and older age does not exclude germline RB1 gene mutation. ( 16343894 )
2006
30
Age at diagnosis of isolated unilateral retinoblastoma does not distinguish patients with and without a constitutional RB1 gene mutation but is influenced by a parent-of-origin effect. ( 15763650 )
2005
31
Neoadjuvant chemotherapy for extensive unilateral retinoblastoma. ( 12598448 )
2003
32
Leydig cell tumor and mature teratoma: unusual non-ocular tumors associated with sexual pseudo-precocity six years after unilateral retinoblastoma. ( 11920800 )
2002
33
Chemoreduction for unilateral retinoblastoma. ( 12470138 )
2002
34
Electroretinographic changes in the inner retinal layers of the retained eyes of patients with sporadic unilateral retinoblastoma. ( 12187428 )
2002
35
Brief report: conservative treatment in unilateral retinoblastoma: a preliminary report. ( 11984807 )
2002
36
Evaluation of chemoprophylaxis in patients with unilateral retinoblastoma with high-risk features on histopathologic examination. ( 11146725 )
2001
37
Isolated granulocytic myelodysplasia in a child with unilateral retinoblastoma. ( 11020113 )
2000
38
A constitutional homozygous mutation in the RB1 gene in a patient with unilateral retinoblastoma. ( 10991691 )
2000
39
Metachronous tumor development in unilateral retinoblastoma. ( 10887927 )
2000
40
Mutation of the RB1 gene caused unilateral retinoblastoma in early Age. ( 10812163 )
2000
41
Is screening for primitive neuroectodermal tumors in patients with unilateral retinoblastoma necessary? ( 10675872 )
2000
42
RB1 gene mutations in peripheral blood DNA of patients with isolated unilateral retinoblastoma. ( 9973307 )
1999
43
No association between the presence of a constitutional RB1 gene mutation and age in 68 patients with isolated unilateral retinoblastoma. ( 10533490 )
1999
44
Frequency and nature of germline Rb-1 gene mutations in a series of patients with sporadic unilateral retinoblastoma. ( 10673998 )
1999
45
Age at diagnosis to discriminate those patients for whom constitutional DNA sequencing is appropriate in sporadic unilateral retinoblastoma. ( 10023315 )
1998
46
Unilateral retinoblastoma with acquired monosomy 7 and secondary acute myelomonocytic leukemia. ( 9689935 )
1998
47
Unilateral retinoblastoma in an adult. ( 9373097 )
1997
48
Cerebral primitive neuro-ectodermal tumour following treatment of a unilateral retinoblastoma. ( 9309290 )
1997
49
Constitutional RB1-gene mutations in patients with isolated unilateral retinoblastoma. ( 9311732 )
1997
50
Unilateral retinoblastoma in an adult: report of a case and review of the literature. ( 9022103 )
1997

Variations for Unilateral Retinoblastoma

Expression for Unilateral Retinoblastoma

Search GEO for disease gene expression data for Unilateral Retinoblastoma.

Pathways for Unilateral Retinoblastoma

Pathways related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.85 DHFR RB1 RBL1
2 11.49 RB1 RBL1
3 11.27 DHFR RB1
4
Show member pathways
10.97 RB1 RBL1
5 10.66 DHFR RB1 RBL1
6 10.16 RB1 RBL1

GO Terms for Unilateral Retinoblastoma

Cellular components related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 8.62 RB1 RBL1

Biological processes related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell cycle GO:0051726 9.26 RB1 RBL1
2 regulation of mitotic cell cycle GO:0007346 9.16 RB1 RBL1
3 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 8.96 RB1 RBL1
4 regulation of lipid kinase activity GO:0043550 8.62 RB1 RBL1

Molecular functions related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001078 9.16 RB1 RBL1
2 RNA polymerase II activating transcription factor binding GO:0001102 8.96 RB1 RBL1
3 RNA polymerase II regulatory region DNA binding GO:0001012 8.62 RB1 RBL1

Sources for Unilateral Retinoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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