MCID: UNV002
MIFTS: 26

Univentricular Heart

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Univentricular Heart

Summaries for Univentricular Heart

MalaCards based summary : Univentricular Heart, also known as double inlet left ventricle, is related to univentricular heart with single atrio-ventricular valve and heart disease. An important gene associated with Univentricular Heart is MIR129-2 (MicroRNA 129-2). The drugs Dobutamine and Ambrisentan have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and kidney.

Related Diseases for Univentricular Heart

Graphical network of the top 20 diseases related to Univentricular Heart:



Diseases related to Univentricular Heart

Symptoms & Phenotypes for Univentricular Heart

Drugs & Therapeutics for Univentricular Heart

Drugs for Univentricular Heart (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 97)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dobutamine Approved Phase 4 34368-04-2 36811
2
Ambrisentan Approved, Investigational Phase 4,Phase 2 177036-94-1 6918493
3
Spironolactone Approved Phase 4,Not Applicable 52-01-7, 1952-01-7 5833
4
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
5
Eplerenone Approved Phase 4 107724-20-9 443872 150310
6
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 77-92-9 311
7 Sympathomimetics Phase 4
8 Protective Agents Phase 4,Phase 2,Not Applicable
9 Adrenergic beta-Agonists Phase 4
10 Adrenergic Agonists Phase 4
11 Adrenergic Agents Phase 4
12 Sildenafil Citrate Phase 4,Phase 2,Phase 1 171599-83-0
13 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
14 Peripheral Nervous System Agents Phase 4,Phase 3
15 Autonomic Agents Phase 4
16 Citrate Phase 4,Phase 2,Phase 1
17 Neurotransmitter Agents Phase 4
18 Vasodilator Agents Phase 4,Phase 2,Phase 1
19 Cardiotonic Agents Phase 4,Phase 2
20 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
21 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
22 Hormones Phase 4,Not Applicable
23 Hormone Antagonists Phase 4,Not Applicable
24 Mineralocorticoids Phase 4,Not Applicable
25 Diuretics, Potassium Sparing Phase 4,Not Applicable
26 diuretics Phase 4,Not Applicable
27 Natriuretic Agents Phase 4,Phase 2,Phase 3,Not Applicable
28 Mineralocorticoid Receptor Antagonists Phase 4,Not Applicable
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Not Applicable
30 Adrenergic alpha-1 Receptor Antagonists Phase 4
31 Adrenergic beta-Antagonists Phase 4
32 Adrenergic alpha-Antagonists Phase 4
33 Adrenergic Antagonists Phase 4
34
Enalapril Approved, Vet_approved Phase 3 75847-73-3 5362032 40466924
35
Enalaprilat Approved Phase 3 76420-72-9 6917719
36
Colchicine Approved Phase 2, Phase 3 64-86-8 6167 2833
37
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
38
Rivaroxaban Approved Phase 3 366789-02-8
39
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
40
Udenafil Investigational Phase 3,Phase 1,Phase 2 268203-93-6 6918523
41 HIV Protease Inhibitors Phase 3,Phase 2
42
protease inhibitors Phase 3,Phase 2
43 Angiotensin-Converting Enzyme Inhibitors Phase 3,Phase 2
44 Anticoagulants Phase 3,Phase 1
45 Antimitotic Agents Phase 2, Phase 3
46 Antirheumatic Agents Phase 2, Phase 3,Phase 3
47 Vasoconstrictor Agents Phase 2, Phase 3,Phase 3
48 arginine Phase 2, Phase 3,Phase 3
49 Arginine Vasopressin Phase 2, Phase 3,Phase 3
50 Hemostatics Phase 2, Phase 3,Phase 3

Interventional clinical trials:

(show top 50) (show all 109)
# Name Status NCT ID Phase Drugs
1 Study of Effects of Sildenafil on Patients With Fontan Heart Circulation Completed NCT01815502 Phase 4
2 The Effects of Ambrisentan on Exercise Capacity in Fontan Patients Completed NCT01971580 Phase 4 Ambrisentan
3 Effect of Carvedilol on Exercise Performance in Fontan Patients Recruiting NCT02946892 Phase 4 Carvedilol;Placebo
4 The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart Disease Terminated NCT01971593 Phase 4 Eplerenone
5 Hybrid Versus Norwood Management Strategies in Infants Undergoing Single Ventricle Palliation Unknown status NCT01134302 Phase 3
6 Trial of Angiotensin Converting Enzyme Inhibition in Infants With Single Ventricle--Pediatric Heart Network Completed NCT00113087 Phase 3 Enalapril;Placebo
7 Comparison of Two Types of Shunts in Infants With Single Ventricle Defect Undergoing Staged Reconstruction--Pediatric Heart Network Completed NCT00115934 Phase 3
8 Biventricular Pacing In Patients With Left Ventricular Dysfunction After Cardiovascular Surgery Completed NCT00321295 Phase 3
9 A Extension Study of Udenafil in Adolescents Recruiting NCT03013751 Phase 3 Udenafil
10 Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial) Recruiting NCT02781922 Phase 3
11 Colchicine in Postoperative Fontan Patients Recruiting NCT03575572 Phase 2, Phase 3 Colchicine
12 Early Use of Vasopressin in Post-Fontan Management Recruiting NCT03088345 Phase 2, Phase 3 Vasopressin, Arginine;Placebos
13 Pharmacokinetic, Pharmacodynamic, Safety, and Efficacy Study of Rivaroxaban for Thromboprophylaxis in Pediatric Participants 2 to 8 Years of Age After the Fontan Procedure Recruiting NCT02846532 Phase 3 Rivaroxaban;Acetylsalicylic Acid
14 Fontan Udenafil Exercise Longitudinal Assessment Trial Active, not recruiting NCT02741115 Phase 3 Udenafil;Placebo
15 An Upcoming Clinical Study to Measure the Safety and Impact of a Drug Called Macitentan in Teenage and Adult Fontan Patients. Not yet recruiting NCT03775421 Phase 3 macitentan 10 mg
16 Use of Vasopressin Following the Fontan Operation Suspended NCT02975999 Phase 2, Phase 3 Vasopressin;Normal Saline
17 Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease (PERSEUS) Completed NCT01829750 Phase 2
18 Bosentan Therapy in Children With Functional Single Ventricle Completed NCT01662037 Phase 2 Bosentan
19 Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology. Completed NCT01292551 Phase 2 Bosentan;Placebo
20 Pharmacokinetic/Pharmacodynamic Study of Udenafil in Adolescents Completed NCT02201342 Phase 1, Phase 2 Udenafil
21 Pathophysiological Mechanisms of Hepatopulmonary Influence in the Fontan Circulation Completed NCT00263406 Phase 2 Administration of an ACE-inhibitor or not
22 Sildenafil After the Fontan Operation Completed NCT00507819 Phase 2 Sildenafil;Placebo
23 Transfusion Strategies in Pediatric Cardiothoracic Surgery Completed NCT00350220 Phase 2
24 Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle Recruiting NCT03079401 Phase 1, Phase 2
25 Ambrisentan in Single Ventricle Active, not recruiting NCT02080637 Phase 2 Ambrisentan
26 Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome (AutoCell-S2) Not yet recruiting NCT03779711 Phase 2
27 Effects of Perioperative Nesiritide or Milrinone Infusion on Recovery From Fontan Surgery Terminated NCT00543309 Phase 2 nesiritide;milrinone;placebo
28 Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle Physiology Completed NCT01273857 Phase 1
29 Sildenafil in Single Ventricle Patients Completed NCT01169519 Phase 1 Sildenafil by injection;Sildenafil by injection;Sildenafil by injection;Sildenafil by injection
30 Effect of Tadalafil on Exercise Capacity in Pediatric Fontan Patients Completed NCT01291069 Phase 1 Tadalafil Citrate;Sugar pill
31 A Pilot Study Investigating the Clinical Use of Tissue Engineered Vascular Grafts in Congenital Heart Surgery Completed NCT01034007 Phase 1
32 Liothyronine in Children With Single Ventricle Congenital Cardiac Malformations Undergoing the Fontan Procedure Completed NCT00004828 Phase 1 liothyronine I 131
33 Feasibility and Efficacy of Portable Non-invasive Negative Pressure Ventilation in Fontan Patients Completed NCT03251742 Phase 1
34 Pilot/Ph I Safety and Efficacy of ODSH in Protein Losing Enteropathy Secondary to Single Ventricle Palliative Surgery Terminated NCT01161641 Phase 1 ODSH at 0.125 mg/kg/h;ODSH at 0.375 mg/kg/h;ODSH at 0.250 mg/kg/h
35 Biomarkers for Feeding Intolerance in Infants With Complex Congenital Heart Defects Undergoing Single Ventricle Staged Palliation Unknown status NCT02995577
36 Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI Techniques Unknown status NCT01107990
37 Cardiovascular, Pulmonary and Skeletal Muscle Evaluation in Late Postoperative Period of the Fontan Surgery Unknown status NCT02283255 Not Applicable
38 Pulmonary Functions Test in Patients After Fontan Operation Unknown status NCT01413308
39 Cardio Pulmonary Exercise Testing in Patients Post the Fontan Palliation in Comparison With Patients With Repaired Congenital Heart Disease and Healthy Volunteers. Unknown status NCT02659462
40 Prospective Analysis of Cerebral Perfusion Using Head Ultrasound and Multi-source-detector Near Infrared Spectroscopy (NIRS) Imaging Unknown status NCT01082536
41 T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart Disease Unknown status NCT02350829 Not Applicable
42 Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction Completed NCT02135081
43 Nutritional Failure in Infants With Single Ventricle Congenital Heart Disease Completed NCT01821287
44 Single Ventricle Outcome Completed NCT00308217
45 Impact of Early Intervention on Maternal Stress in Mothers of Fetuses Diagnosed With Single Ventricle Physiology Completed NCT02462434 Not Applicable
46 Endothelin Blockade in Patients With Single Ventricle Physiology Completed NCT00989911 Not Applicable Bosentan
47 Multisite Feeding Study: Home Surveillance and Feeding Strategies in Infants With Complex Single Ventricle Completed NCT00257517
48 Outcomes of Children With Congenital Single Ventricle Heart Completed NCT00266968
49 Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy Completed NCT00165984
50 Training in Exercise Activities and Motion for Growth Completed NCT01917084 Not Applicable

Search NIH Clinical Center for Univentricular Heart

Genetic Tests for Univentricular Heart

Anatomical Context for Univentricular Heart

MalaCards organs/tissues related to Univentricular Heart:

41
Heart, Lung, Kidney, Liver, Testes, Atrioventricular Node

Publications for Univentricular Heart

Articles related to Univentricular Heart:

(show top 50) (show all 278)
# Title Authors Year
1
Long-Term Effects of Percutaneous Fenestration Following the Fontan Procedure in Adult Patients with Congenital Univentricular Heart. ( 29802801 )
2018
2
Blood-threshold CMR volume analysis of functional univentricular heart. ( 29357037 )
2018
3
Subclavicular arteriovenous fistula for univentricular heart palliation. ( 30070780 )
2018
4
State of the art of the Fontan strategy for treatment of univentricular heart disease. ( 30002816 )
2018
5
Diagnostic accuracy of low-dose dual-source cardiac computed tomography as compared to surgery in univentricular heart patients. ( 29769130 )
2018
6
Anatomy of the Functionally Univentricular Heart. ( 30322358 )
2018
7
Incidence and Outcomes of Patients with Functionally Univentricular Heart Born in Latvia, 2007 to 2015. ( 30344275 )
2018
8
A restrictive ventilatory pattern is common in patients with univentricular heart after Fontan palliation and associated with a reduced exercise capacity and quality of life. ( 30378270 )
2018
9
201Tl Myocardial Perfusion Imaging in a Case of Double-Inlet Left Ventricle: Correlate Anatomic Information of SPECT With MRI. ( 29293140 )
2018
10
An Unusual Combination of Double Inlet Left Ventricle With Discordant Ventriculoarterial Connections and Bilateral Arterial Ducts. ( 29334828 )
2018
11
Extracardiac Conduit Fontan Operation with Reduction Aortoplasty for Left Pulmonary Artery Compression after a Norwood Procedure in a Patient with Double-Inlet Left Ventricle. ( 29430429 )
2018
12
Improvements in exercise capacity following cardiac transplantation in a patient born with double inlet left ventricle. ( 29437740 )
2018
13
Arterial Switch, Ventricular Septation, and Fontan Takedown for Double Inlet Left Ventricle. ( 29673637 )
2018
14
Risk factors for in-hospital shunt thrombosis and mortality in patients weighing less than 3a88kg with functionally univentricular heart undergoing a modified Blalock-Taussig shunt. ( 28520941 )
2017
15
Plasma microvesicle analysis identifies microRNA 129-5p as a biomarker of heart failure in univentricular heart disease. ( 28859128 )
2017
16
Intracoronary Cardiac Progenitor Cells in Single Ventricle Physiology: The PERSEUS (Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease) Randomized Phase 2 Trial. ( 28052915 )
2017
17
Stenting of narrow pulmonary artery banding in a patient with univentricular heart. ( 29057003 )
2017
18
Anomalous origin of the left coronary artery from the right pulmonary artery in a univentricular heart. ( 28651676 )
2017
19
Improved long-term outcomes in double-inlet left ventricle and tricuspid atresia with transposed great arteries: systemic outflow tract obstruction present at birth defines long-term outcome. ( 28329058 )
2017
20
First-stage palliation strategy for univentricular heart disease may impact risk for acute kidney injury. ( 28889816 )
2017
21
Living with functionally univentricular heart: beating the odds? ( 29214833 )
2017
22
Impact of Abernathy malformation on pulmonary circulatory hemodynamics in a univentricular heart. ( 28163439 )
2017
23
A Comparative Study of Histopathological Changes in the Ascending Aorta and the Risk Factors Related to Histopathological Conditions and Aortic Dilatation in Patients with Tetralogy of Fallot and a Functionally Univentricular Heart. ( 29111162 )
2017
24
Intra-Atrial Y-Graft Fontan for Univentricular Heart With Discontinuous Pulmonary Arteries. ( 28696884 )
2017
25
Current Results of Single Ventricle Palliation of Patients With Double Inlet Left Ventricle. ( 28709664 )
2017
26
Transvenous biventricular pacing in double-inlet left ventricle following ventricular septation and atrioventricular valve replacement. ( 28398485 )
2017
27
Stenting of the ductus arteriosus in infants with functionally univentricular heart disease and ductal-dependent pulmonary blood flow: A single-center experience. ( 27862912 )
2016
28
Surgical approach for systemic-pulmonary shunt in neonates with functionally univentricular heart: comparison between sternotomy and thoracotomy. ( 27300351 )
2016
29
Commentary on "Changes in Motor Development During a 4-Year Follow-up on Children With Univentricular Heart Defects". ( 27661240 )
2016
30
Prenatal diagnosis of functionally univentricular heart, associations and perinatal outcomes. ( 27061183 )
2016
31
Comparative Evaluation of Flow Quantification across the Atrioventricular Valve in Patients with Functional Univentricular Heart after Fontan's Surgery and Healthy Controls: Measurement by 4D Flow Magnetic Resonance Imaging and Streamline Visualization. ( 27425568 )
2016
32
Changes in Motor Development During a 4-Year Follow-up on Children With Univentricular Heart Defects. ( 27661239 )
2016
33
Functionally Univentricular Heart With Right Atrial Isomerism and Mixed Total Anomalous Pulmonary Venous Drainage. ( 26701620 )
2016
34
Elevated Low-Shear Blood Viscosity is Associated with Decreased Pulmonary Blood Flow in Children with Univentricular Heart Defects. ( 26888364 )
2016
35
Double inlet left ventricle with unrestricted pulmonary blood flow and survival into adulthood. ( 26795443 )
2016
36
Double inlet left ventricle-ventriculoarterial discordance without surgical treatment. ( 27322861 )
2016
37
Can Univentricular Heart Be Associated with "Rigid Body Rotation"? A Case from the ThreeDimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study. ( 25854450 )
2015
38
Thrombocytosis in the Setting of Isomerism and a Functionally Univentricular Heart. ( 26719826 )
2015
39
Decision-Making for Surgery in the Management of Patients with Univentricular Heart. ( 26284226 )
2015
40
Mechanics of the Functionally Univentricular Heart-How Little Do We Understand and Why Does It Matter? ( 26919793 )
2015
41
Single-stage septation of a univentricular heart: 26 years later. ( 25623904 )
2015
42
Incidental finding of an univentricular heart on echocardiogram in an adult patient. ( 25468956 )
2015
43
Editorial: Univentricular Heart. ( 26442235 )
2015
44
A 74-year-old unoperated univentricular heart: the oldest reported survival. ( 26508431 )
2015
45
Truncus arteriosus, tricuspid atresia and partial anomalous pulmonary venous drainage: a unique form of univentricular heart. ( 25972595 )
2015
46
Evidence for improved outcome for children born with a univentricular heart defect? ( 25904767 )
2015
47
Radiofrequency catheter ablation of atrial tachyarrhythmias after an atrial switch operation in a patient with univentricular heart combined with transposition of the great arteries. ( 25275370 )
2015
48
Heart rate variability in patients undergoing univentricular heart repair. ( 24771727 )
2014
49
The new concept of univentricular heart. ( 25072035 )
2014
50
Anaesthesia in a patient with univentricular heart for emergency craniotomy: A case report. ( 25197131 )
2014

Variations for Univentricular Heart

Expression for Univentricular Heart

Search GEO for disease gene expression data for Univentricular Heart.

Pathways for Univentricular Heart

GO Terms for Univentricular Heart

Sources for Univentricular Heart

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....