MCID: UNN001
MIFTS: 11

Unna-Thost Palmoplantar Keratoderma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Unna-Thost Palmoplantar Keratoderma

MalaCards integrated aliases for Unna-Thost Palmoplantar Keratoderma:

Name: Unna-Thost Palmoplantar Keratoderma 52
Diffuse Nonepidermolytic Palmoplantar Keratoderma 52
Thost-Unna Palmoplantar Keratoderma 52
Ppk Diffusa Circumscripta 52
Thost-Unna Disease 52
Diffuse Neppk 52

Classifications:



Summaries for Unna-Thost Palmoplantar Keratoderma

NIH Rare Diseases : 52 Unna-Thost palmoplantar keratoderma is a type of diffuse palmoplantar keratoderma that mostly affects the palms of the hands and soles of the feet. It usually begins in early childhood with redness of the palms and soles. The palms and soles gradually become thicker and develop a yellowish, waxy appearance. Increased sweating (hyperhidrosis ) is quite common and there is a tendency to fungal and bacterial infections of the feet. This condition usually does not extend beyond the hands and feet. It may affect the knuckle pads and nails, but usually does not involve the thin skin on the top of the feet or hands. Unna-Thost palmoplantar keratoderma is inherited in an autosomal dominant fashion and caused by mutations in the KRT1 gene .

MalaCards based summary : Unna-Thost Palmoplantar Keratoderma, also known as diffuse nonepidermolytic palmoplantar keratoderma, is related to palmoplantar keratoderma, nonepidermolytic, focal or diffuse and palmoplantar keratoderma, nonepidermolytic. Affiliated tissues include skin.

Related Diseases for Unna-Thost Palmoplantar Keratoderma

Graphical network of the top 20 diseases related to Unna-Thost Palmoplantar Keratoderma:



Diseases related to Unna-Thost Palmoplantar Keratoderma

Symptoms & Phenotypes for Unna-Thost Palmoplantar Keratoderma

Drugs & Therapeutics for Unna-Thost Palmoplantar Keratoderma

Search Clinical Trials , NIH Clinical Center for Unna-Thost Palmoplantar Keratoderma

Genetic Tests for Unna-Thost Palmoplantar Keratoderma

Anatomical Context for Unna-Thost Palmoplantar Keratoderma

MalaCards organs/tissues related to Unna-Thost Palmoplantar Keratoderma:

40
Skin

Publications for Unna-Thost Palmoplantar Keratoderma

Articles related to Unna-Thost Palmoplantar Keratoderma:

(showing 8, show less)
# Title Authors PMID Year
1
Novel Splice-Site Mutation of KRT1 Underlies Diffuse Palmoplantar Keratoderma in a Large Chinese Pedigree. 61
30452289 2018
2
A novel heterozygous missense mutation of the desmoglein 1 gene in a Chinese family with diffuse nonepidermolytic palmoplantar keratoderma. 61
29770786 2018
3
Autosomal dominant diffuse nonepidermolytic palmoplantar keratoderma due to a recurrent mutation in aquaporin-5. 61
26032342 2016
4
Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. 61
23830519 2013
5
What is your diagnosis? Diffuse nonepidermolytic palmoplantar keratoderma with woolly hair and cardiomyopathy (Naxos-Carvajal syndrome). 61
20486455 2010
6
Diffuse nonepidermolytic palmoplantar keratoderma caused by a recurrent nonsense mutation in DSG1. 61
15897387 2005
7
Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism. 61
10620133 2000
8
Gene for arrhythmogenic right ventricular cardiomyopathy with diffuse nonepidermolytic palmoplantar keratoderma and woolly hair (Naxos disease) maps to 17q21. 61
9610536 1998

Variations for Unna-Thost Palmoplantar Keratoderma

Expression for Unna-Thost Palmoplantar Keratoderma

Search GEO for disease gene expression data for Unna-Thost Palmoplantar Keratoderma.

Pathways for Unna-Thost Palmoplantar Keratoderma

GO Terms for Unna-Thost Palmoplantar Keratoderma

Sources for Unna-Thost Palmoplantar Keratoderma

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