MCID: UPP004
MIFTS: 43

Upper Respiratory Tract Disease

Categories: Respiratory diseases

Aliases & Classifications for Upper Respiratory Tract Disease

MalaCards integrated aliases for Upper Respiratory Tract Disease:

Name: Upper Respiratory Tract Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:974
ICD9CM 35 478.1 478.19
ICD10 33 J39.8
UMLS 73 C0029581

Summaries for Upper Respiratory Tract Disease

Disease Ontology : 12 A respiratory system disease which involves the upper respiratory tract.

MalaCards based summary : Upper Respiratory Tract Disease is related to tonsillitis and common cold. An important gene associated with Upper Respiratory Tract Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Clarithromycin and Cytochrome P-450 CYP3A Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Upper Respiratory Tract Disease

Diseases related to Upper Respiratory Tract Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 305)
# Related Disease Score Top Affiliating Genes
1 tonsillitis 31.9 CXCL8 IFNG IL4 TLR9 TNF
2 common cold 31.8 CCL11 CXCL8 IL13 IL5 RNASE3 TLR9
3 chlamydia 30.4 CXCL8 IFNG IL10 IL4 TNF
4 conjunctivitis 30.1 CCL11 CXCL8 HRH1 IFNG IL13 IL4
5 adenoiditis 11.0
6 laryngotracheitis 11.0
7 uvulitis 11.0
8 adenoid hypertrophy 11.0
9 acute laryngopharyngitis 11.0
10 pharyngitis 11.0
11 scarlet fever 11.0
12 epiglottitis 11.0
13 loeffler endocarditis 10.4 IL5 RNASE3
14 cytokine deficiency 10.4 IL13 IL5
15 eye lymphoma 10.4 IL10 TLR9
16 pemphigoid gestationis 10.4 CCL11 IL5
17 bagassosis 10.4 CXCL8 IL5
18 tracheitis 10.4 RHNO1 TNF
19 ascaridiasis 10.4 IL10 IL13
20 eosinophilic fasciitis 10.4 IFNG IL5
21 borderline leprosy 10.4 MLLT1 SDHD
22 microscopic polyangiitis 10.4 IL10 TNF
23 multifocal choroiditis 10.4 IL10 TNF
24 punctate inner choroidopathy 10.4 IL10 TNF
25 exudative glomerulonephritis 10.4 CXCL8 TNF
26 palladium allergic contact dermatitis 10.4 IL10 IL17A
27 streptococcal toxic-shock syndrome 10.4 CXCL8 TNF
28 acute transverse myelitis 10.4 CXCL8 IL10
29 arteries, anomalies of 10.4 TLR9 TNF TRPV1
30 staphylococcal toxic shock syndrome 10.4 IFNG TNF
31 acquired metabolic disease 10.4 TLR9 TNF TRPV1
32 pollen allergy 10.4 IL13 IL5 RNASE3
33 yellow fever 10.4 IL4 IL5 TLR9
34 dry eye syndrome 10.4 TLR9 TNF TRPV1
35 intestinal schistosomiasis 10.4 IL13 IL4 IL5
36 urinary system disease 10.4 TLR9 TNF TRPV1
37 acute generalized exanthematous pustulosis 10.4 CXCL8 IL17A
38 chronic tic disorder 10.4 IL13 IL4 IL5
39 glucose metabolism disease 10.4 TLR9 TNF TRPV1
40 night blindness, congenital stationary, type 1a 10.4 CCL11 IL13 IL5
41 cellulitis 10.4 IL5 RNASE3 TNF
42 bullous pemphigoid 10.4 CCL11 IL5 RNASE3
43 chronic eosinophilic pneumonia 10.4 CCL11 IL5 RNASE3
44 stomach disease 10.4 CXCL8 TLR9 TRPV1
45 genital herpes 10.4 IL10 IL4 TLR9
46 beta-lactam allergy 10.4 IL10 IL13 IL4
47 status asthmaticus 10.4 CXCL8 IL5 RNASE3
48 chronic maxillary sinusitis 10.4 MUC5B RHNO1 RNASE3
49 autoimmune gastritis 10.4 IL10 IL4 TNF
50 wells syndrome 10.4 CXCL8 IL5 RNASE3

Graphical network of the top 20 diseases related to Upper Respiratory Tract Disease:



Diseases related to Upper Respiratory Tract Disease

Symptoms & Phenotypes for Upper Respiratory Tract Disease

MGI Mouse Phenotypes related to Upper Respiratory Tract Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 CCL11 HRH1 IFNG IL10 IL13 IL17A
2 immune system MP:0005387 10.22 CCL11 CYSLTR1 HRH1 IFNG IL10 IL13
3 growth/size/body region MP:0005378 10.21 HRH1 IFNG IL10 IL13 IL17A IL4
4 homeostasis/metabolism MP:0005376 10.18 HRH1 IFNG IL10 IL13 IL17A IL4
5 digestive/alimentary MP:0005381 10.11 IFNG IL10 IL13 IL17A IL4 IL5
6 liver/biliary system MP:0005370 9.86 HRH1 IFNG IL10 IL4 IL5 MLLT1
7 neoplasm MP:0002006 9.7 IFNG IL10 IL5 MLLT1 SDHD TNF
8 no phenotypic analysis MP:0003012 9.5 IFNG IL10 IL13 IL17A IL4 TNF
9 respiratory system MP:0005388 9.36 CCL11 CYSLTR1 IFNG IL10 IL13 IL17A

Drugs & Therapeutics for Upper Respiratory Tract Disease

Drugs for Upper Respiratory Tract Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved 81103-11-9 84029
2 Cytochrome P-450 CYP3A Inhibitors
3 Cytochrome P-450 Enzyme Inhibitors
4 Anti-Bacterial Agents
5 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosing Respiratory Disease in Children Using Cough Sounds 2 Completed NCT03392363
2 Evaluation of the Treatment With Klacid SR in Patients With Acute Tracheitis, Tracheobronchitis and Bronchitis, Acute Exacerbation of Chronic Bronchitis and Mild Community-acquired Pneumonia in Common Clinical Practice in Ukraine Completed NCT01095978 Clarithromycin (Klacid SR)

Search NIH Clinical Center for Upper Respiratory Tract Disease

Genetic Tests for Upper Respiratory Tract Disease

Anatomical Context for Upper Respiratory Tract Disease

MalaCards organs/tissues related to Upper Respiratory Tract Disease:

41
Brain, Lung, Bone, Heart, Lymph Node, Eye, T Cells

Publications for Upper Respiratory Tract Disease

Articles related to Upper Respiratory Tract Disease:

(show top 50) (show all 54)
# Title Authors Year
1
High quality draft genome sequences of <i>Mycoplasma agassizii</i> strains PS6<sup>T</sup> and 723 isolated from <i>Gopherus</i> tortoises with upper respiratory tract disease. ( 29725499 )
2018
2
Prevalence of feline herpesvirus-1, feline calicivirus, Chlamydophila felis and Mycoplasma felis DNA and associated risk factors in cats in Spain with upper respiratory tract disease, conjunctivitis and/or gingivostomatitis. ( 26919892 )
2016
3
Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease. ( 27166137 )
2016
4
Sampling sites for detection of feline herpesvirus-1, feline calicivirus and Chlamydia felis in cats with feline upper respiratory tract disease. ( 25660223 )
2015
5
Detection of feline upper respiratory tract disease pathogens using a commercially available real-time PCR test. ( 26324635 )
2015
6
Effects of mycoplasmal upper-respiratory-tract disease on movement and thermoregulatory behavior of gopher tortoises (Gopherus polyphemus) in Georgia, USA. ( 25121399 )
2014
7
Mycoplasmosis and upper respiratory tract disease of tortoises: a review and update. ( 24951264 )
2014
8
Surveillance for upper respiratory tract disease and Mycoplasma in free-ranging gopher tortoises (Gopherus polyphemus) in Georgia, USA. ( 25098305 )
2014
9
An association between Helicobacter pylori and upper respiratory tract disease: fact or fiction? ( 24587622 )
2014
10
Impacts of upper respiratory tract disease on olfactory behavior of the Mojave desert tortoise. ( 24506425 )
2014
11
Mycoplasmal upper respiratory tract disease across the range of the threatened Mojave Desert tortoise: associations with thermal regime and natural antibodies. ( 23579813 )
2013
12
Surveillance of upper respiratory tract disease in owned cats in Australia, 2009-2012. ( 23910025 )
2013
13
Comparison of the efficacy of amoxicillin-clavulanic acid, cefovecin, and doxycycline in the treatment of upper respiratory tract disease in cats housed in an animal shelter. ( 22765368 )
2012
14
Upper respiratory tract disease in captive orangutans (Pongo sp.): prevalence in 20 European zoos and predisposing factors. ( 21770970 )
2011
15
Infectious causes for feline upper respiratory tract disease--a case-control study. ( 20851008 )
2010
16
Flow cytometric method for quantifying viable Mycoplasma agassizii, an agent of upper respiratory tract disease in the desert tortoise (Gopherus agassizii). ( 20132436 )
2010
17
Effects of mycoplasmal upper respiratory tract disease on morbidity and mortality of gopher tortoises in northern and central Florida. ( 20688675 )
2010
18
Detection of bacterial and viral organisms from the conjunctiva of cats with conjunctivitis and upper respiratory tract disease. ( 20817584 )
2010
19
Descriptive epidemiology of feline upper respiratory tract disease in an animal shelter. ( 19782625 )
2009
20
Upper respiratory tract disease, force of infection, and effects on survival of gopher tortoises. ( 19425439 )
2009
21
Risk factors for time to diagnosis of feline upper respiratory tract disease in UK animal adoption shelters. ( 18639946 )
2008
22
Efficacy of pradofloxacin in cats with feline upper respiratory tract disease due to Chlamydophila felis or Mycoplasma infections. ( 18289288 )
2008
23
Prevalence of selected infectious organisms and comparison of two anatomic sampling sites in shelter cats with upper respiratory tract disease. ( 18539065 )
2008
24
An investigation into the role of Chlamydophila spp. in bovine upper respiratory tract disease. ( 16624729 )
2006
25
Nasal levels of nitric oxide as an outcome variable in allergic upper respiratory tract disease: Influence of atopy and hayfever on nNO. ( 17063731 )
2006
26
Factors associated with upper respiratory tract disease caused by feline herpesvirus, feline calicivirus, Chlamydophila felis and Bordetella bronchiseptica in cats: experience from 218 European catteries. ( 15908495 )
2005
27
Correlation of rhinoscopic signs of inflammation with histologic findings in nasal biopsy specimens of cats with or without upper respiratory tract disease. ( 15328715 )
2004
28
Mycoplasma testudineum sp. nov., from a desert tortoise (Gopherus agassizii) with upper respiratory tract disease. ( 15388705 )
2004
29
Occurrence of infectious upper respiratory tract disease and response to vaccination in horses on six sentinel premises in northern Colorado. ( 12553466 )
2003
30
Upper respiratory tract disease in tortoises. ( 14509583 )
2003
31
An etiological investigation of domestic cats with conjunctivitis and upper respiratory tract disease in Japan. ( 11999440 )
2002
32
Feline upper respiratory tract disease. ( 10907225 )
2000
33
A study of feline upper respiratory tract disease with reference to prevalence and risk factors for infection with feline calicivirus and feline herpesvirus. ( 11716607 )
2000
34
Pathology of upper respiratory tract disease of gopher tortoises in Florida. ( 10813609 )
2000
35
Seroepidemiology of upper respiratory tract disease in the desert tortoise in the western Mojave Desert of California. ( 10574531 )
1999
36
Prevalence of feline Chlamydia psittaci and feline herpesvirus 1 in cats with upper respiratory tract disease. ( 10357102 )
1999
37
Upper respiratory tract disease in the gopher tortoise is caused by Mycoplasma agassizii. ( 10364595 )
1999
38
Comparison of Chlamydia psittaci from cats with upper respiratory tract disease by polymerase chain reaction analysis of the ompA gene. ( 9106964 )
1997
39
Upper respiratory tract disease and mycoplasmosis in desert tortoises from Nevada. ( 9391959 )
1997
40
Relationship between clinical signs of upper respiratory tract disease and antibodies to Mycoplasma agassizii in desert tortoises from Nevada. ( 9131556 )
1997
41
Molecular characterization of Pasteurella testudinis isolated from desert tortoises (Gopherus agassizii) with and without upper respiratory tract disease. ( 7563420 )
1995
42
Mycoplasma agassizii causes upper respiratory tract disease in the desert tortoise. ( 7927724 )
1994
43
Detection of antibodies to a pathogenic mycoplasma in desert tortoises (Gopherus agassizii) with upper respiratory tract disease. ( 8314986 )
1993
44
Chronic upper respiratory tract disease of free-ranging desert tortoises (Xerobates agassizii). ( 2067052 )
1991
45
Bacterial adherence and upper respiratory tract disease: a correlation between S. pyogenes attachment and recurrent throat infections. ( 3066104 )
1988
46
Epidemiology of equine upper respiratory tract disease on standardbred racetracks. ( 218705 )
1979
47
Intranasal vaccination against upper respiratory tract disease (U.R.D.) in the cat--II. Results of field studies under enzootic conditions in the Netherlands with a combined vaccine containing live attenuated calici- and herpesvirus. ( 757151 )
1978
48
Intranasal vaccination against upper respiratory tract disease (U.R.D.) in the cat--I. Virological and serological observations in cats suffering from U.R.D. ( 757150 )
1978
49
Office diagnosis of streptococcal upper respiratory tract disease. ( 1091982 )
1975
50
Viral isolation rates during summer from children with acute upper respiratory tract disease and healthy children. ( 4358333 )
1974

Variations for Upper Respiratory Tract Disease

Expression for Upper Respiratory Tract Disease

Search GEO for disease gene expression data for Upper Respiratory Tract Disease.

Pathways for Upper Respiratory Tract Disease

Pathways related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 CCL11 CXCL8 IFNG IL10 IL13 IL17A
2
Show member pathways
13.71 CCL11 CXCL8 IFNG IL10 IL13 IL17A
3
Show member pathways
13.57 CCL11 CXCL8 IFNG IL10 IL13 IL17A
4
Show member pathways
13.45 CCL11 CXCL8 IL10 IL13 IL17A IL4
5
Show member pathways
13.4 CCL11 CXCL8 IFNG IL10 IL13 IL17A
6
Show member pathways
13.33 CCL11 CXCL8 IL10 IL13 IL17A IL4
7
Show member pathways
12.88 CCL11 CXCL8 IFNG IL10 IL13 IL17A
8
Show member pathways
12.83 CXCL8 IFNG IL13 IL4 TLR9 TNF
9 12.82 CXCL8 IFNG IL13 IL4 IL5
10
Show member pathways
12.67 IFNG IL10 IL13 IL17A IL4 IL5
11
Show member pathways
12.65 IFNG IL10 IL4 MS4A2 TNF
12 12.62 IFNG IL10 IL17A IL4 TLR9 TNF
13
Show member pathways
12.61 IL13 IL4 IL5 MS4A2 TNF
14
Show member pathways
12.5 IFNG IL10 IL17A IL4 IL5 TNF
15
Show member pathways
12.47 IFNG IL10 IL13 IL4 IL5 TSLP
16
Show member pathways
12.32 CXCL8 IFNG IL10 IL13 IL17A IL4
17
Show member pathways
12.27 IFNG IL10 IL4 TNF
18 12.25 IFNG IL10 TLR9 TNF
19
Show member pathways
12.25 CCL11 CXCL8 IFNG IL4 TLR9 TNF
20 12.2 CXCL8 IL10 IL13 TNF
21
Show member pathways
12.14 CCL11 CXCL8 IFNG IL10 IL13 IL17A
22
Show member pathways
12.14 CCL11 CXCL8 IFNG IL13 IL17A IL4
23
Show member pathways
12.13 IFNG IL10 IL17A TLR9 TNF
24
Show member pathways
12.08 IFNG IL13 IL4 TNF
25 12.08 CCL11 CXCL8 IL10 IL13 IL17A IL4
26 12.07 IFNG IL10 IL4 IL5 TNF
27 12.05 CXCL8 IFNG IL4 TNF
28 11.94 CXCL8 IFNG IL10 TNF
29 11.91 CXCL8 IFNG IL17A TNF
30 11.9 CXCL8 IFNG IL13 IL4 IL5
31 11.87 IL4 IL5 TNF
32
Show member pathways
11.85 CXCL8 IFNG IL4 IL5 TNF
33 11.81 IFNG IL10 TLR9 TNF
34 11.76 CXCL8 IL10 TNF
35 11.76 CCL11 IFNG IL10 IL13 IL17A IL4
36 11.73 CCL11 IL10 IL4 IL5
37
Show member pathways
11.68 CXCL8 IFNG TNF
38 11.64 CXCL8 IL10 IL13 IL4 TNF
39 11.62 CXCL8 IFNG IL10 TLR9 TNF
40 11.6 CCL11 IFNG IL10 IL13 IL4 IL5
41 11.6 CCL11 CXCL8 IL13 IL4 IL5 MUC5B
42 11.54 CCL11 CXCL8 TSLP
43 11.46 IFNG IL10 IL13 IL17A IL4 IL5
44 11.44 IFNG IL10 TLR9 TNF
45 11.37 IFNG IL4 IL5
46 11.31 IFNG IL10 IL13 IL4 IL5
47 11.27 CCL11 CXCL8 IL10 IL13 IL17A IL4
48 11.26 IFNG IL10 IL13 IL4 IL5 TNF
49 11.08 CCL11 CXCL8 IL10 IL13 IL17A IL4
50 10.67 IFNG IL13 IL17A IL4 IL5 TNF

GO Terms for Upper Respiratory Tract Disease

Cellular components related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 CCL11 CXCL8 IFNG IL10 IL13 IL17A
2 external side of plasma membrane GO:0009897 9.55 IL13 IL17A MS4A2 TNF TRPV1
3 extracellular space GO:0005615 9.4 CCL11 CXCL8 IFNG IL10 IL13 IL17A

Biological processes related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.96 CYSLTR1 IFNG MS4A2 TRPV1
2 defense response to bacterium GO:0042742 9.96 IL10 RNASE3 TLR9 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.86 CCL11 CXCL8 IL10 IL13 IL17A IL4
4 regulation of signaling receptor activity GO:0010469 9.85 CCL11 CXCL8 IFNG IL10 IL13 IL17A
5 cellular response to interleukin-1 GO:0071347 9.83 CCL11 CXCL8 IL17A
6 positive regulation of inflammatory response GO:0050729 9.82 TLR9 TNF TSLP
7 positive regulation of interleukin-6 production GO:0032755 9.79 TLR9 TNF TSLP
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IFNG TNF TRPV1
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.73 IL10 IL13 IL4
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 IFNG IL13 IL4 TSLP
11 immune response GO:0006955 9.7 CCL11 CXCL8 IFNG IL10 IL13 IL17A
12 negative regulation of interleukin-6 production GO:0032715 9.69 IL10 TLR9 TNF
13 positive regulation of podosome assembly GO:0071803 9.66 IL5 TNF
14 positive regulation of osteoclast differentiation GO:0045672 9.65 IFNG IL17A TNF
15 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.64 TLR9 TNF
16 positive regulation of interleukin-13 production GO:0032736 9.64 IL4 TSLP
17 endothelial cell apoptotic process GO:0072577 9.63 IL10 TNF
18 positive regulation of immunoglobulin production GO:0002639 9.63 IL13 TLR9
19 positive regulation of chemokine production GO:0032722 9.63 TLR9 TNF TSLP
20 positive regulation of B cell proliferation GO:0030890 9.62 IL13 IL4 IL5 TLR9
21 negative regulation of interleukin-8 production GO:0032717 9.61 IL10 TLR9
22 positive regulation of MHC class II biosynthetic process GO:0045348 9.61 IL10 IL4
23 microglial cell activation GO:0001774 9.61 IL13 TNF TRPV1
24 negative regulation of cytokine secretion involved in immune response GO:0002740 9.6 IL10 TNF
25 positive regulation of interleukin-23 production GO:0032747 9.59 IFNG IL17A
26 regulation of isotype switching GO:0045191 9.58 IL10 IL4
27 type 2 immune response GO:0042092 9.57 IL10 IL4
28 negative regulation of complement-dependent cytotoxicity GO:1903660 9.55 IL13 IL4
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IFNG TNF
30 response to molecule of bacterial origin GO:0002237 9.54 CXCL8 IL10 TLR9
31 receptor biosynthetic process GO:0032800 9.52 IL10 TNF
32 positive regulation of vitamin D biosynthetic process GO:0060557 9.49 IFNG TNF
33 inflammatory response GO:0006954 9.36 CCL11 CXCL8 HRH1 IL10 IL13 IL17A
34 positive regulation of gene expression GO:0010628 10.02 IFNG IL13 IL4 TLR9 TNF

Molecular functions related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 CCL11 CXCL8 IFNG IL10 IL13 IL17A

Sources for Upper Respiratory Tract Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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