MCID: UPP004
MIFTS: 42

Upper Respiratory Tract Disease

Categories: Respiratory diseases

Aliases & Classifications for Upper Respiratory Tract Disease

MalaCards integrated aliases for Upper Respiratory Tract Disease:

Name: Upper Respiratory Tract Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:974
ICD9CM 35 478.1 478.19
SNOMED-CT 68 195823002 266346007
ICD10 33 J39.8
UMLS 73 C0029581

Summaries for Upper Respiratory Tract Disease

Disease Ontology : 12 A respiratory system disease which involves the upper respiratory tract.

MalaCards based summary : Upper Respiratory Tract Disease is related to tonsillitis and common cold. An important gene associated with Upper Respiratory Tract Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Clarithromycin and Cytochrome P-450 CYP3A Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include testes and brain, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Upper Respiratory Tract Disease

Diseases related to Upper Respiratory Tract Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 217)
# Related Disease Score Top Affiliating Genes
1 tonsillitis 31.9 CD79A CXCL8 IL4 TLR9 TNF
2 common cold 31.0 CCL11 CXCL8 IL13 IL33 IL5 RNASE3
3 chlamydia 30.8 CD79A CXCL8 TNF
4 conjunctivitis 29.7 CCL11 CXCL8 IL13 IL33 IL4 IL5
5 cytokine deficiency 11.0 IL13 IL5
6 chronic interstitial cystitis 11.0 CD79A RNASE3
7 loeffler endocarditis 11.0 IL5 RNASE3
8 intrinsic asthma 11.0 IL4 IL5 RNASE3
9 atopic keratoconjunctivitis 11.0 IL4 IL5 RNASE3
10 paragonimiasis 11.0 IL13 IL5 RNASE3
11 blepharoconjunctivitis 11.0 CCL11 IL4 RNASE3
12 exudative glomerulonephritis 10.9 CD79A CXCL8
13 pemphigoid gestationis 10.9 CCL11 IL5
14 cow milk allergy 10.9 CD79A IL5 RNASE3
15 eosinophilic gastroenteritis 10.9 CCL11 IL5 RNASE3
16 chronic eosinophilic pneumonia 10.9 CCL11 IL5 RNASE3
17 apple allergy 10.9 IL13 IL4 IL5
18 maxillary sinusitis 10.9 CD79A RHNO1 RNASE3
19 intestinal schistosomiasis 10.9 IL13 IL4 IL5
20 chronic tic disorder 10.9 IL13 IL4 IL5
21 parasitic ichthyosporea infectious disease 10.9 CD79A IL4 RHNO1
22 rhinosporidiosis 10.9 CD79A IL4 RHNO1
23 adenoiditis 10.9
24 laryngotracheitis 10.9
25 uvulitis 10.9
26 adenoid hypertrophy 10.9
27 acute laryngopharyngitis 10.9
28 pharyngitis 10.9
29 scarlet fever 10.9
30 epiglottitis 10.9
31 primary amebic meningoencephalitis 10.9 CD79A IL4 IL5
32 tropical endomyocardial fibrosis 10.9 IL4 TNF
33 status asthmaticus 10.9 CXCL8 IL5 RNASE3
34 ascaris lumbricoides infection 10.9 IL13 IL5 TSLP
35 bagassosis 10.9 CXCL8 IL5
36 encapsulated thymoma 10.9 CD79A MUC5B
37 night blindness, congenital stationary, type 1a 10.9 CCL11 IL13 IL5
38 ocular cicatricial pemphigoid 10.9 CD79A IL4 RNASE3
39 wells syndrome 10.9 CXCL8 IL5 RNASE3
40 papillary conjunctivitis 10.9 CCL11 CXCL8 IL4
41 sezary's disease 10.8 IL4 IL5 TLR9
42 anisakiasis 10.8 CD79A RNASE3
43 cough variant asthma 10.8 IL4 IL5 RNASE3 TRPV1
44 interstitial cystitis 10.8 CXCL8 IL4 TRPV1
45 ocular toxoplasmosis 10.8 CD79A IL17A TLR9
46 dermatitis herpetiformis 10.8 CCL11 CD79A IL4
47 invasive aspergillosis 10.8 CD79A CXCL8 TLR9
48 angioimmunoblastic lymphadenopathy with dysproteinemia 10.8 IL13 IL5 TNF
49 yellow fever 10.8 IL17A IL5 TLR9
50 lacrimal apparatus disease 10.8 TLR9 TNF TRPV1

Graphical network of the top 20 diseases related to Upper Respiratory Tract Disease:



Diseases related to Upper Respiratory Tract Disease

Symptoms & Phenotypes for Upper Respiratory Tract Disease

MGI Mouse Phenotypes related to Upper Respiratory Tract Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.17 CCL11 IL4 CD79A IL5 HRH1 IL13
2 homeostasis/metabolism MP:0005376 10.1 IL33 IL4 CD79A IL5 HRH1 IL13
3 immune system MP:0005387 10.06 CCL11 IL4 CD79A CYSLTR1 IL5 HRH1
4 digestive/alimentary MP:0005381 9.97 IL33 IL4 IL5 IL13 IL17A TLR9
5 no phenotypic analysis MP:0003012 9.5 IL33 CD79A IL4 IL13 IL17A TNF
6 respiratory system MP:0005388 9.32 CCL11 IL4 CYSLTR1 IL5 IL13 MUC5B

Drugs & Therapeutics for Upper Respiratory Tract Disease

Drugs for Upper Respiratory Tract Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved 81103-11-9 84029
2 Cytochrome P-450 CYP3A Inhibitors
3 Cytochrome P-450 Enzyme Inhibitors
4 Anti-Bacterial Agents
5 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Treatment With Klacid SR in Patients With Acute Tracheitis, Tracheobronchitis and Bronchitis, Acute Exacerbation of Chronic Bronchitis and Mild Community-acquired Pneumonia in Common Clinical Practice in Ukraine Completed NCT01095978 Clarithromycin (Klacid SR)
2 Diagnosing Respiratory Disease in Children Using Cough Sounds 2 Recruiting NCT03392363

Search NIH Clinical Center for Upper Respiratory Tract Disease

Genetic Tests for Upper Respiratory Tract Disease

Anatomical Context for Upper Respiratory Tract Disease

MalaCards organs/tissues related to Upper Respiratory Tract Disease:

41
Testes, Brain

Publications for Upper Respiratory Tract Disease

Articles related to Upper Respiratory Tract Disease:

(show top 50) (show all 54)
# Title Authors Year
1
High quality draft genome sequences of <i>Mycoplasma agassizii</i> strains PS6<sup>T</sup> and 723 isolated from <i>Gopherus</i> tortoises with upper respiratory tract disease. ( 29725499 )
2018
2
Prevalence of feline herpesvirus-1, feline calicivirus, Chlamydophila felis and Mycoplasma felis DNA and associated risk factors in cats in Spain with upper respiratory tract disease, conjunctivitis and/or gingivostomatitis. ( 26919892 )
2016
3
Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease. ( 27166137 )
2016
4
Sampling sites for detection of feline herpesvirus-1, feline calicivirus and Chlamydia felis in cats with feline upper respiratory tract disease. ( 25660223 )
2015
5
Detection of feline upper respiratory tract disease pathogens using a commercially available real-time PCR test. ( 26324635 )
2015
6
Effects of mycoplasmal upper-respiratory-tract disease on movement and thermoregulatory behavior of gopher tortoises (Gopherus polyphemus) in Georgia, USA. ( 25121399 )
2014
7
Mycoplasmosis and upper respiratory tract disease of tortoises: a review and update. ( 24951264 )
2014
8
Surveillance for upper respiratory tract disease and Mycoplasma in free-ranging gopher tortoises (Gopherus polyphemus) in Georgia, USA. ( 25098305 )
2014
9
An association between Helicobacter pylori and upper respiratory tract disease: fact or fiction? ( 24587622 )
2014
10
Impacts of upper respiratory tract disease on olfactory behavior of the Mojave desert tortoise. ( 24506425 )
2014
11
Mycoplasmal upper respiratory tract disease across the range of the threatened Mojave Desert tortoise: associations with thermal regime and natural antibodies. ( 23579813 )
2013
12
Surveillance of upper respiratory tract disease in owned cats in Australia, 2009-2012. ( 23910025 )
2013
13
Comparison of the efficacy of amoxicillin-clavulanic acid, cefovecin, and doxycycline in the treatment of upper respiratory tract disease in cats housed in an animal shelter. ( 22765368 )
2012
14
Upper respiratory tract disease in captive orangutans (Pongo sp.): prevalence in 20 European zoos and predisposing factors. ( 21770970 )
2011
15
Infectious causes for feline upper respiratory tract disease--a case-control study. ( 20851008 )
2010
16
Flow cytometric method for quantifying viable Mycoplasma agassizii, an agent of upper respiratory tract disease in the desert tortoise (Gopherus agassizii). ( 20132436 )
2010
17
Effects of mycoplasmal upper respiratory tract disease on morbidity and mortality of gopher tortoises in northern and central Florida. ( 20688675 )
2010
18
Detection of bacterial and viral organisms from the conjunctiva of cats with conjunctivitis and upper respiratory tract disease. ( 20817584 )
2010
19
Descriptive epidemiology of feline upper respiratory tract disease in an animal shelter. ( 19782625 )
2009
20
Upper respiratory tract disease, force of infection, and effects on survival of gopher tortoises. ( 19425439 )
2009
21
Risk factors for time to diagnosis of feline upper respiratory tract disease in UK animal adoption shelters. ( 18639946 )
2008
22
Efficacy of pradofloxacin in cats with feline upper respiratory tract disease due to Chlamydophila felis or Mycoplasma infections. ( 18289288 )
2008
23
Prevalence of selected infectious organisms and comparison of two anatomic sampling sites in shelter cats with upper respiratory tract disease. ( 18539065 )
2008
24
An investigation into the role of Chlamydophila spp. in bovine upper respiratory tract disease. ( 16624729 )
2006
25
Nasal levels of nitric oxide as an outcome variable in allergic upper respiratory tract disease: Influence of atopy and hayfever on nNO. ( 17063731 )
2006
26
Factors associated with upper respiratory tract disease caused by feline herpesvirus, feline calicivirus, Chlamydophila felis and Bordetella bronchiseptica in cats: experience from 218 European catteries. ( 15908495 )
2005
27
Correlation of rhinoscopic signs of inflammation with histologic findings in nasal biopsy specimens of cats with or without upper respiratory tract disease. ( 15328715 )
2004
28
Mycoplasma testudineum sp. nov., from a desert tortoise (Gopherus agassizii) with upper respiratory tract disease. ( 15388705 )
2004
29
Occurrence of infectious upper respiratory tract disease and response to vaccination in horses on six sentinel premises in northern Colorado. ( 12553466 )
2003
30
Upper respiratory tract disease in tortoises. ( 14509583 )
2003
31
An etiological investigation of domestic cats with conjunctivitis and upper respiratory tract disease in Japan. ( 11999440 )
2002
32
Feline upper respiratory tract disease. ( 10907225 )
2000
33
A study of feline upper respiratory tract disease with reference to prevalence and risk factors for infection with feline calicivirus and feline herpesvirus. ( 11716607 )
2000
34
Pathology of upper respiratory tract disease of gopher tortoises in Florida. ( 10813609 )
2000
35
Seroepidemiology of upper respiratory tract disease in the desert tortoise in the western Mojave Desert of California. ( 10574531 )
1999
36
Prevalence of feline Chlamydia psittaci and feline herpesvirus 1 in cats with upper respiratory tract disease. ( 10357102 )
1999
37
Upper respiratory tract disease in the gopher tortoise is caused by Mycoplasma agassizii. ( 10364595 )
1999
38
Comparison of Chlamydia psittaci from cats with upper respiratory tract disease by polymerase chain reaction analysis of the ompA gene. ( 9106964 )
1997
39
Upper respiratory tract disease and mycoplasmosis in desert tortoises from Nevada. ( 9391959 )
1997
40
Relationship between clinical signs of upper respiratory tract disease and antibodies to Mycoplasma agassizii in desert tortoises from Nevada. ( 9131556 )
1997
41
Molecular characterization of Pasteurella testudinis isolated from desert tortoises (Gopherus agassizii) with and without upper respiratory tract disease. ( 7563420 )
1995
42
Mycoplasma agassizii causes upper respiratory tract disease in the desert tortoise. ( 7927724 )
1994
43
Detection of antibodies to a pathogenic mycoplasma in desert tortoises (Gopherus agassizii) with upper respiratory tract disease. ( 8314986 )
1993
44
Chronic upper respiratory tract disease of free-ranging desert tortoises (Xerobates agassizii). ( 2067052 )
1991
45
Bacterial adherence and upper respiratory tract disease: a correlation between S. pyogenes attachment and recurrent throat infections. ( 3066104 )
1988
46
Epidemiology of equine upper respiratory tract disease on standardbred racetracks. ( 218705 )
1979
47
Intranasal vaccination against upper respiratory tract disease (U.R.D.) in the cat--II. Results of field studies under enzootic conditions in the Netherlands with a combined vaccine containing live attenuated calici- and herpesvirus. ( 757151 )
1978
48
Intranasal vaccination against upper respiratory tract disease (U.R.D.) in the cat--I. Virological and serological observations in cats suffering from U.R.D. ( 757150 )
1978
49
Office diagnosis of streptococcal upper respiratory tract disease. ( 1091982 )
1975
50
Viral isolation rates during summer from children with acute upper respiratory tract disease and healthy children. ( 4358333 )
1974

Variations for Upper Respiratory Tract Disease

Expression for Upper Respiratory Tract Disease

Search GEO for disease gene expression data for Upper Respiratory Tract Disease.

Pathways for Upper Respiratory Tract Disease

Pathways related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CCL11 CD79A CXCL8 IL13 IL17A IL33
2
Show member pathways
13.64 CCL11 CXCL8 IL13 IL17A IL33 IL4
3
Show member pathways
13.36 CCL11 CXCL8 IL13 IL17A IL4 IL5
4
Show member pathways
13.31 CCL11 CXCL8 IL13 IL17A IL33 IL4
5
Show member pathways
13.25 CCL11 CXCL8 IL13 IL17A IL4 IL5
6
Show member pathways
12.8 CCL11 CXCL8 IL13 IL17A IL4 IL5
7
Show member pathways
12.75 CXCL8 IL13 IL33 IL4 TLR9 TNF
8
Show member pathways
12.57 CXCL8 IL13 IL17A IL4 IL5 TNF
9
Show member pathways
12.53 CD79A IL13 IL4 IL5 MS4A2 TNF
10 12.52 CD79A IL17A IL4 TLR9 TNF
11
Show member pathways
12.41 IL13 IL17A IL4 IL5 TNF
12
Show member pathways
12.36 IL17A IL4 IL5 TNF
13
Show member pathways
12.19 CCL11 CXCL8 IL13 IL17A IL4 IL5
14
Show member pathways
12.17 CXCL8 IL33 MUC5B TNF
15
Show member pathways
12.13 CCL11 CXCL8 IL4 TLR9 TNF
16
Show member pathways
12.04 CCL11 CXCL8 IL13 IL17A IL4 IL5
17 11.94 CD79A IL4 IL5 PTGDR2 TNF
18 11.9 CCL11 CXCL8 IL13 IL17A IL4 TNF
19 11.82 IL4 IL5 TNF
20 11.78 CXCL8 IL17A TNF
21 11.77 CXCL8 IL13 IL4 IL5
22
Show member pathways
11.72 CXCL8 IL4 IL5 TNF
23 11.61 CCL11 IL4 IL5
24 11.5 CCL11 CXCL8 IL13 IL4 IL5 MUC5B
25 11.49 CXCL8 TLR9 TNF
26 11.49 CXCL8 IL13 IL4 TNF
27 11.47 CCL11 CXCL8 TSLP
28 11.46 IL13 IL17A IL33 IL4 IL5 PTGDR2
29 11.38 CCL11 IL13 IL33 IL4 IL5
30 11.23 IL13 IL4 IL5 TNF
31 11.17 IL13 IL4 IL5
32 10.67 IL13 IL17A IL33 IL4 IL5 TNF

GO Terms for Upper Respiratory Tract Disease

Cellular components related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CCL11 CXCL8 IL13 IL17A IL33 IL4
2 external side of plasma membrane GO:0009897 9.63 CD79A IL13 IL17A MS4A2 TNF TRPV1
3 extracellular space GO:0005615 9.4 CCL11 CXCL8 IL13 IL17A IL33 IL4

Biological processes related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.89 CD79A CYSLTR1 MS4A2 TRPV1
2 immune response GO:0006955 9.81 CCL11 CXCL8 IL13 IL17A IL4 IL5
3 cytokine-mediated signaling pathway GO:0019221 9.8 CCL11 CXCL8 IL13 IL17A IL4 IL5
4 chemotaxis GO:0006935 9.78 CCL11 CXCL8 CYSLTR1 PTGDR2
5 cellular response to interleukin-1 GO:0071347 9.72 CCL11 CXCL8 IL17A
6 positive regulation of inflammatory response GO:0050729 9.71 IL33 TLR9 TSLP
7 positive regulation of interleukin-6 production GO:0032755 9.71 IL33 TLR9 TNF TSLP
8 positive regulation of B cell proliferation GO:0030890 9.62 IL13 IL4 IL5 TLR9
9 positive regulation of chemokine production GO:0032722 9.61 TLR9 TNF TSLP
10 regulation of signaling receptor activity GO:0010469 9.61 CCL11 CXCL8 IL13 IL17A IL33 IL4
11 positive regulation of macrophage activation GO:0043032 9.6 IL13 IL33
12 microglial cell activation GO:0001774 9.58 IL13 TRPV1
13 response to molecule of bacterial origin GO:0002237 9.58 CXCL8 TLR9
14 positive regulation of immunoglobulin secretion GO:0051024 9.57 IL33 IL5
15 positive regulation of podosome assembly GO:0071803 9.56 IL5 TNF
16 positive regulation of interleukin-13 production GO:0032736 9.54 IL33 IL4 TSLP
17 positive regulation of interleukin-5 production GO:0032754 9.52 IL33 TSLP
18 positive regulation of immunoglobulin production GO:0002639 9.51 IL13 TLR9
19 type 2 immune response GO:0042092 9.49 IL33 IL4
20 negative regulation of complement-dependent cytotoxicity GO:1903660 9.46 IL13 IL4
21 inflammatory response GO:0006954 9.32 CCL11 CXCL8 HRH1 IL13 IL17A IL5

Molecular functions related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CCL11 CXCL8 IL13 IL17A IL33 IL4

Sources for Upper Respiratory Tract Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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