MCID: UPP004
MIFTS: 33

Upper Respiratory Tract Disease

Categories: Respiratory diseases

Aliases & Classifications for Upper Respiratory Tract Disease

MalaCards integrated aliases for Upper Respiratory Tract Disease:

Name: Upper Respiratory Tract Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:974
ICD9CM 34 478.19
SNOMED-CT 67 195823002
ICD10 32 J39.8 J39.9
UMLS 70 C0029581

Summaries for Upper Respiratory Tract Disease

Disease Ontology : 12 A respiratory system disease which involves the upper respiratory tract.

MalaCards based summary : Upper Respiratory Tract Disease is related to disease by infectious agent and tonsillitis. An important gene associated with Upper Respiratory Tract Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and Alzheimers Disease. Affiliated tissues include eye, testes and monocytes.

Related Diseases for Upper Respiratory Tract Disease

Diseases related to Upper Respiratory Tract Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
# Related Disease Score Top Affiliating Genes
1 disease by infectious agent 30.8 MIR93 MIR9-1 MIR30A MIR21 MIR199A1 MIR17
2 tonsillitis 11.1
3 adenoiditis 11.1
4 laryngotracheitis 11.1
5 uvulitis 11.1
6 adenoid hypertrophy 11.1
7 common cold 11.1
8 acute laryngopharyngitis 11.1
9 pharyngitis 11.1
10 scarlet fever 11.1
11 epiglottitis 11.1
12 bacterial infectious disease 10.6 MIR155 ICOSLG H2AC18 CCR6
13 intestinal schistosomiasis 10.6 MIR199A1 ICOSLG CCR6
14 autoimmune disease of urogenital tract 10.6 ICOSLG H2AC18 CCR6
15 ureteral disease 10.6 MIR199A1 MIR142 CCR6
16 klebsiella pneumonia 10.6 ICOSLG H2AC18 CCR6
17 autoimmune disease of exocrine system 10.6 MIR155 ICOSLG H2AC18 CCR6
18 miyoshi muscular dystrophy 1 10.6 MIR30A MIR21 MIR155
19 parasitic helminthiasis infectious disease 10.6 MIR21 ICOSLG H2AC18 CCR6
20 blood protein disease 10.6 MIR17 ICOSLG H2AC18 CCR6
21 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.6 ICOSLG H2AC18 CCR6
22 lichen disease 10.6 MIR31 ICOSLG CCR6
23 hypersensitivity reaction type iv disease 10.6 MIR155 ICOSLG H2AC18 CCR6
24 herpangina 10.6 ICOSLG H2AC18 CCR6
25 spinal cord disease 10.6 MIR142 ICOSLG H2AC18 CCR6
26 mature t-cell and nk-cell lymphoma 10.6 MIR199A1 MIR17 ICOSLG H2AC18 CCR6
27 listeriosis 10.6 ICOSLG H2AC18 CCR6
28 esophagus adenocarcinoma 10.6 MIR21 MIR199A1 MIR143
29 thymus gland disease 10.6 MIR125A ICOSLG H2AC18 CCR6
30 thymus cancer 10.6 MIR125A ICOSLG H2AC18 CCR6
31 coccidiosis 10.5 ICOSLG H2AC18 CCR6
32 aortic valve disease 2 10.5 MIR21 MIR199A1 MIR17 MIR106B
33 autoimmune disease of gastrointestinal tract 10.5 MIR199A1 MIR142 ICOSLG H2AC18 CCR6
34 heart valve disease 10.5 MIR21 MIR199A1 MIR17 H2AC18
35 bacterial pneumonia 10.5 MIR155 ICOSLG H2AC18 CCR6
36 anus disease 10.5 ICOSLG H2AC18 CCR6
37 muscle cancer 10.5 MIR9-1 MIR199A1 MIR142 H2AC18
38 renal fibrosis 10.5 MIR29C MIR21 MIR199A1 MIR155
39 intrinsic cardiomyopathy 10.5 MIR21 MIR199A1 MIR142 ICOSLG H2AC18
40 parasitic protozoa infectious disease 10.5 MIR142 ICOSLG H2AC18 CCR6
41 autoimmune disease of cardiovascular system 10.5 ICOSLG H2AC18 CCR6
42 coronavirus infectious disease 10.5 MIR17 H2AC18 CCR6
43 cervix carcinoma 10.5 MIR199A1 MIR142 H2AC18 CCR6
44 ovarian cystadenocarcinoma 10.5 MIR744 MIR30A MIR17
45 intermediate coronary syndrome 10.5 MIR144 MIR142 MIR106B
46 immunodeficiency with hyper-igm, type 1 10.5 ICOSLG H2AC18 CCR6
47 endocrine organ benign neoplasm 10.5 MIR93 MIR21 MIR199A1 MIR142 H2AC18
48 bone resorption disease 10.5 MIR93 MIR199A1 MIR142 H2AC18 CCR6
49 x-linked recessive disease 10.5 MIR142 ICOSLG H2AC18 CCR6
50 autoimmune disease of endocrine system 10.5 MIR142 MIR125A ICOSLG H2AC18 CCR6

Graphical network of the top 20 diseases related to Upper Respiratory Tract Disease:



Diseases related to Upper Respiratory Tract Disease

Symptoms & Phenotypes for Upper Respiratory Tract Disease

Drugs & Therapeutics for Upper Respiratory Tract Disease

Search Clinical Trials , NIH Clinical Center for Upper Respiratory Tract Disease

Genetic Tests for Upper Respiratory Tract Disease

Anatomical Context for Upper Respiratory Tract Disease

MalaCards organs/tissues related to Upper Respiratory Tract Disease:

40
Eye, Testes, Monocytes, Endothelial, Neutrophil

Publications for Upper Respiratory Tract Disease

Articles related to Upper Respiratory Tract Disease:

(show top 50) (show all 296)
# Title Authors PMID Year
1
Implementation of a screening tool for primary ciliary dyskinesia (PCD) in a pediatric otolaryngology clinic. 61
33388601 2021
2
Pathogenic and Transmission Potential of Wildtype and Chicken Embryo Origin (CEO) Vaccine Revertant Infectious Laryngotracheitis Virus. 61
33805117 2021
3
Feline chaphamaparvovirus in cats with enteritis and upper respiratory tract disease. 61
33559350 2021
4
Mycoplasma agassizii, an opportunistic pathogen of tortoises, shows very little genetic variation across the Mojave and Sonoran Deserts. 61
33534823 2021
5
CLINICAL OPHTHALMIC PARAMETERS OF THE TEXAS TORTOISE (GOPHERUS BERLANDIERI). 61
33480568 2021
6
Novel Inactivated Subtype B Avian Metapneumovirus Vaccine Induced Humoral and Cellular Immune Responses. 61
33327513 2020
7
Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control - a comprehensive review. 61
32315579 2020
8
Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation. 61
32415227 2020
9
Randomized clinical trial to assess the effect of antibiotic therapy on health and growth of preweaned dairy calves diagnosed with respiratory disease using respiratory scoring and lung ultrasound. 61
33222860 2020
10
Comparative Study of the Pathogenesis of Rhinopneumonitis Induced by Intranasal Inoculation of Hamsters with Equine Herpesvirus-9, Equine Herpesvirus-1 strain Ab4p and Zebra-borne Equine Herpesvirus-1. 61
33222872 2020
11
A transient increase in MHC-IIlow monocytes after experimental infection with Avibacterium paragallinarum (serovar B-1) in SPF chickens. 61
32977847 2020
12
A Randomized, Placebo-Controlled Clinical Trial of Famciclovir in Shelter Cats with Naturally Occurring Upper Respiratory Tract Disease. 61
32825039 2020
13
Detection of multidrug resistance and extended-spectrum/plasmid-mediated AmpC beta-lactamase genes in Enterobacteriaceae isolates from diseased cats in Italy. 61
31524037 2020
14
Prevalence of feline herpesvirus-1, feline calicivirus, Chlamydia felis, and Bordetella bronchiseptica in a population of shelter cats on Prince Edward Island. 61
32801452 2020
15
Antimicrobial prescriptions in cats in Switzerland before and after the introduction of an online antimicrobial stewardship tool. 61
32620170 2020
16
Effects of famciclovir in cats with spontaneous acute upper respiratory tract disease. 61
31246133 2020
17
Complete Genome Sequence of an Avian Metapneumovirus Subtype B Strain from Hungary. 61
32381608 2020
18
Novel coronavirus disease (COVID-19) in children 61
32304191 2020
19
The clinical benefit of instituting a prospective clinical community-acquired respiratory virus surveillance program in allogeneic hematopoietic stem cell transplantation. 61
31972212 2020
20
Validation of specific quantitative real-time RT-PCR assay panel for Infectious Bronchitis using synthetic DNA standards and clinical specimens. 61
31712094 2020
21
Bayesian Network Modeling Applied to Feline Calicivirus Infection Among Cats in Switzerland. 61
32175337 2020
22
MANAGEMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME IN A CHILD WITH ADENOVIRUS PNEUMONIA: CASE REPORT AND LITERATURE REVIEW. 61
32187298 2020
23
Multiple Correspondence Analysis on Amino Acid Properties within the Variable Region of the Capsid Protein Shows Differences between Classical and Virulent Systemic Feline Calicivirus Strains. 61
31771183 2019
24
Cat flu: Broad spectrum polymeric antivirals. 61
31325462 2019
25
A QUANTITATIVE PCR ASSAY FOR A MYCOPLASMA FROM EMYDID TURTLES INDICATES HIGH PREVALENCE IN HEALTHY THREE-TOED BOX TURTLES (TERRAPENE CAROLINA TRIUNGUIS) FROM MISSOURI, USA. 61
30822209 2019
26
[Treatment of acute viral feline upper respiratory tract infections]. 61
31013527 2019
27
Antimicrobial use for selected diseases in cats in Switzerland. 61
30871537 2019
28
Genomic sequence and pathogenicity of the first avian metapneumovirus subtype B isolated from chicken in China. 61
30593377 2019
29
Upper respiratory tract disease and associated diagnostic tests of mycoplasmosis in Alabama populations of Gopher tortoises, Gopherus polyphemus. 61
30951541 2019
30
Investigation onto the correlation between systemic antibodies to surface glycoproteins of infectious laryngotracheitis virus (ILTV) and protective immunity. 61
30593375 2019
31
Investigation of a Large-Scale Gopher Tortoise ( Gopherus polyphemus) Mortality Event on a Public Conservation Land in Florida, USA. 61
29792758 2018
32
The slow dynamics of mycoplasma infections in a tortoise host reveal heterogeneity pertinent to pathogen transmission and monitoring. 61
30251621 2018
33
Potential Therapeutic Agents for Feline Calicivirus Infection. 61
30115859 2018
34
Calicivirus co-infections in herpesvirus pneumonia in kittens. 61
29871741 2018
35
Transcutaneous immunization with pneumococcal surface protein A in mice. 61
29226330 2018
36
High quality draft genome sequences of Mycoplasma agassizii strains PS6T and 723 isolated from Gopherus tortoises with upper respiratory tract disease. 61
29725499 2018
37
[Nasal irrigation: opportunities and disadvantages]. 61
30721193 2018
38
Lateral rhinostomy for treatment of severe chronic rhinosinusitis in two rabbits. 61
29244604 2018
39
Infectious Laryngotracheitis Virus Viral Chemokine-Binding Protein Glycoprotein G Alters Transcription of Key Inflammatory Mediators In Vitro and In Vivo. 61
29070686 2018
40
Determination of the minimum protective dose of a glycoprotein-G-deficient infectious laryngotracheitis virus vaccine delivered via eye-drop to week-old chickens. 61
30521554 2018
41
Identifying genome-wide immune gene variation underlying infectious disease in wildlife populations - a next generation sequencing approach in the gopher tortoise. 61
29351737 2018
42
High quality draft genome sequence of Mycoplasma testudineum strain BH29T, isolated from the respiratory tract of a desert tortoise. 61
29682170 2018
43
Chronic disease in the Mojave desert tortoise: Host physiology and recrudescence obscure patterns of pathogen transmission. 61
29299243 2017
44
Co-infection does not predict disease signs in Gopherus tortoises. 61
29134096 2017
45
Isolation and phylogenetic analysis of three feline calicivirus strains from domestic cats in Jilin Province, China. 61
28478577 2017
46
Respiratory viruses in transplant recipients: more than just a cold. Clinical syndromes and infection prevention principles. 61
28739424 2017
47
Evaluation of the ERIC-PCR as a probable method to differentiate Avibacterium paragallinarum serovars. 61
27866411 2017
48
MOLECULAR DETECTION OF INFECTIOUS PATHOGENS OF THE UPPER RESPIRATORY TRACT IN CAPTIVE NONDOMESTIC FELIDS. 61
28749292 2017
49
Prevalence of feline herpesvirus-1, feline calicivirus, Chlamydophila felis and Mycoplasma felis DNA and associated risk factors in cats in Spain with upper respiratory tract disease, conjunctivitis and/or gingivostomatitis. 61
26919892 2017
50
Recombinase Polymerase Amplification Assay-A Simple, Fast and Cost-Effective Alternative to Real Time PCR for Specific Detection of Feline Herpesvirus-1. 61
28045956 2017

Variations for Upper Respiratory Tract Disease

Expression for Upper Respiratory Tract Disease

Search GEO for disease gene expression data for Upper Respiratory Tract Disease.

Pathways for Upper Respiratory Tract Disease

Pathways related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 MIR9-1 MIR34C MIR31 MIR30A MIR29C MIR21
2 11.43 MIR9-1 MIR34C MIR21 MIR125A
3 11.36 MIR34C MIR30A MIR17
4 11.03 MIR93 MIR34C MIR106B

GO Terms for Upper Respiratory Tract Disease

Cellular components related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 MIR9-1 MIR29C MIR21 MIR17 MIR155 MIR143
2 extracellular vesicle GO:1903561 9.56 MIR93 MIR30A MIR29C MIR21 MIR185 MIR17
3 extracellular space GO:0005615 9.5 MIR93 MIR744 MIR31 MIR30A MIR29C MIR21

Biological processes related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell migration GO:0030336 9.88 MIR93 MIR9-1 MIR29C MIR21
2 positive regulation of angiogenesis GO:0045766 9.85 MIR31 MIR30A MIR21 MIR199A1 MIR143
3 cholesterol homeostasis GO:0042632 9.82 MIR185 MIR155 MIR144
4 negative regulation of gene expression GO:0010629 9.81 MIR93 MIR29C MIR21 MIR185 MIR17 MIR155
5 positive regulation of inflammatory response GO:0050729 9.8 MIR21 MIR155 MIR144
6 negative regulation of angiogenesis GO:0016525 9.8 MIR29C MIR21 MIR185 MIR143 MIR125A MIR106B
7 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.77 MIR29C MIR199A1 MIR155
8 positive regulation of blood vessel endothelial cell migration GO:0043536 9.76 MIR31 MIR30A MIR143
9 negative regulation of interleukin-8 production GO:0032717 9.74 MIR93 MIR155 MIR106B
10 negative regulation of cytokine production involved in inflammatory response GO:1900016 9.72 MIR93 MIR155 MIR125A
11 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.71 MIR21 MIR199A1 MIR106B
12 negative regulation of vascular endothelial growth factor production GO:1904046 9.71 MIR93 MIR199A1 MIR17 MIR125A
13 positive regulation of sprouting angiogenesis GO:1903672 9.7 MIR31 MIR155 MIR125A
14 positive regulation of activated T cell proliferation GO:0042104 9.69 MIR21 MIR155 ICOSLG
15 negative regulation of amyloid precursor protein biosynthetic process GO:0042985 9.67 MIR31 MIR17 MIR144
16 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.67 MIR199A1 MIR185 MIR17 MIR155
17 positive regulation of connective tissue replacement GO:1905205 9.65 MIR34C MIR199A1 MIR155
18 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.64 MIR17 MIR155
19 negative regulation of cytokine-mediated signaling pathway GO:0001960 9.63 MIR21 MIR125A
20 positive regulation of microglial cell activation GO:1903980 9.62 MIR155 MIR142
21 positive regulation of metalloendopeptidase activity GO:1904685 9.62 MIR21 MIR17
22 negative regulation of bicellular tight junction assembly GO:1903347 9.61 MIR155 MIR142
23 negative regulation of regulatory T cell differentiation GO:0045590 9.61 MIR21 MIR155
24 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.61 MIR31 MIR155 MIR125A
25 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.6 MIR21 MIR17
26 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.56 MIR17 MIR143
27 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.56 MIR34C MIR199A1 MIR17 MIR155
28 miRNA mediated inhibition of translation GO:0035278 9.56 MIR9-1 MIR31 MIR29C MIR21 MIR17 MIR155
29 gene silencing by miRNA GO:0035195 9.55 MIR93 MIR9-1 MIR744 MIR34C MIR31 MIR30A

Molecular functions related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.73 MIR93 MIR9-1 MIR31 MIR30A MIR29C MIR21
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.5 MIR93 MIR9-1 MIR31 MIR30A MIR29C MIR21

Sources for Upper Respiratory Tract Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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