MCID: UPP004
MIFTS: 36

Upper Respiratory Tract Disease

Categories: Respiratory diseases

Aliases & Classifications for Upper Respiratory Tract Disease

MalaCards integrated aliases for Upper Respiratory Tract Disease:

Name: Upper Respiratory Tract Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:974
ICD9CM 34 478.1 478.19
ICD10 32 J39.8 J39.9
UMLS 71 C0029581

Summaries for Upper Respiratory Tract Disease

Disease Ontology : 12 A respiratory system disease which involves the upper respiratory tract.

MalaCards based summary : Upper Respiratory Tract Disease is related to laryngeal disease and mycobacterium tuberculosis 1. An important gene associated with Upper Respiratory Tract Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and Parkinsons Disease Pathway. The drugs leucovorin and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and thyroid.

Related Diseases for Upper Respiratory Tract Disease

Diseases related to Upper Respiratory Tract Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 laryngeal disease 31.4 MIR93 MIR744 MIR34C MIR27A MIR21 MIR20A
2 mycobacterium tuberculosis 1 30.9 MIR21 ICOSLG H2AC18 CCR6
3 tonsillitis 11.5
4 pharyngitis 11.5
5 adenoiditis 11.2
6 laryngotracheitis 11.2
7 uvulitis 11.2
8 adenoid hypertrophy 11.2
9 common cold 11.2
10 acute laryngopharyngitis 11.2
11 scarlet fever 11.2
12 epiglottitis 11.2
13 thyroid gland anaplastic carcinoma 10.8 MIR34C MIR30A MIR17
14 extrinsic cardiomyopathy 10.8 MIR21 ICOSLG H2AC18 CCR6
15 parasitic helminthiasis infectious disease 10.8 MIR21 ICOSLG H2AC18 CCR6
16 spinal cord disease 10.7 MIR142 ICOSLG H2AC18 CCR6
17 idiopathic interstitial pneumonia 10.7 MIR21 MIR199A1 MIR142 CCR6
18 lymphatic system cancer 10.7 MIR17 MIR142 ICOSLG H2AC18 CCR6
19 skin melanoma 10.7 MIR29C MIR199A1 ICOSLG H2AC18 CCR6
20 heart conduction disease 10.7 MIR21 MIR199A1 MIR142 H2AC18
21 listeriosis 10.7 ICOSLG H2AC18 CCR6
22 serous cystadenocarcinoma 10.7 MIR30A MIR199A1 H2AC18
23 thymus gland disease 10.7 MIR125A ICOSLG H2AC18 CCR6
24 bone resorption disease 10.7 MIR199A1 MIR142 H2AC18 CCR6
25 uveal disease 10.7 MIR9-1 MIR199A1 MIR142 ICOSLG H2AC18 CCR6
26 autoimmune disease of endocrine system 10.7 MIR125A ICOSLG H2AC18 CCR6
27 bone remodeling disease 10.7 MIR199A1 MIR142 H2AC18 CCR6
28 coccidiosis 10.7 ICOSLG H2AC18 CCR6
29 thymus cancer 10.7 MIR125A ICOSLG H2AC18 CCR6
30 gallbladder disease 10.7 MIR29C MIR199A1 MIR17 MIR143 MIR142
31 iga glomerulonephritis 10.7 MIR30A ICOSLG CCR6
32 autoimmune disease of urogenital tract 10.7 ICOSLG H2AC18 CCR6
33 colonic benign neoplasm 10.7 MIR20A MIR143 H2AC18 CCR6
34 collagen disease 10.7 MIR30A MIR21 MIR142 ICOSLG H2AC18 CCR6
35 bronchial disease 10.7 MIR21 MIR17 MIR142 ICOSLG H2AC18 CCR6
36 intrinsic cardiomyopathy 10.7 MIR30A MIR21 MIR199A1 MIR142 ICOSLG H2AC18
37 esophagus adenocarcinoma 10.7 MIR21 MIR196A1 MIR143
38 pleural cancer 10.7 MIR29C MIR185 MIR17 H2AC18
39 breast carcinoma in situ 10.7 MIR30A MIR17 MIR143 MIR142
40 lymphoma, hodgkin, classic 10.7 MIR30A MIR21 MIR20A ICOSLG CCR6
41 pre-malignant neoplasm 10.7 MIR30A MIR17 MIR142 H2AC18
42 aortic valve disease 2 10.7 MIR21 MIR199A1 MIR17 MIR106B
43 combined t cell and b cell immunodeficiency 10.7 ICOSLG H2AC18 CCR6
44 retinal vascular disease 10.7 MIR30A MIR21 MIR20A MIR199A1 H2AC18
45 tongue disease 10.7 MIR30A MIR21 MIR199A1 MIR196A1 MIR17 CCR6
46 bone cancer 10.7 MIR9-1 MIR27A MIR21 MIR20A MIR199A1
47 marginal zone b-cell lymphoma 10.7 MIR9-1 MIR142 CCR6
48 neuromuscular junction disease 10.7 ICOSLG H2AC18 CCR6
49 feingold syndrome 1 10.7 MIR20A MIR17 MIR106B
50 muscle cancer 10.7 MIR9-1 MIR199A1 MIR196A1 MIR143 H2AC18

Graphical network of the top 20 diseases related to Upper Respiratory Tract Disease:



Diseases related to Upper Respiratory Tract Disease

Symptoms & Phenotypes for Upper Respiratory Tract Disease

Drugs & Therapeutics for Upper Respiratory Tract Disease

Drugs for Upper Respiratory Tract Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 1, Phase 2 58-05-9 6006 143
2
Sulfamethoxazole Approved Phase 1, Phase 2 723-46-6 5329
3
Trimethoprim Approved, Vet_approved Phase 1, Phase 2 738-70-5 5578
4
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
5 Anti-Infective Agents Phase 1, Phase 2
6 Renal Agents Phase 1, Phase 2
7 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
8 Aluminum hydroxide, magnesium hydroxide, simethicone drug combination Phase 1, Phase 2
9 Folic Acid Antagonists Phase 1, Phase 2
10 Antiparasitic Agents Phase 1, Phase 2
11 Vitamin B Complex Phase 1, Phase 2
12 Antimalarials Phase 1, Phase 2
13 Antiprotozoal Agents Phase 1, Phase 2
14 Vitamin B9 Phase 1, Phase 2
15 Anti-Infective Agents, Urinary Phase 1, Phase 2
16 TEMPO Phase 1, Phase 2
17 Folate Phase 1, Phase 2
18 Trimethoprim, Sulfamethoxazole Drug Combination Phase 1, Phase 2
19 Anti-Bacterial Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trimethoprim-Sulfamethoxazole Effects on the Nasal Microbiome in Granulomatosis With Polyangiitis Recruiting NCT03919435 Phase 1, Phase 2 Trimethoprim Sulfamethoxazole
2 Diagnosing Respiratory Disease in Children Using Smartphone Recordings of Cough Sounds 2 Completed NCT03392363

Search NIH Clinical Center for Upper Respiratory Tract Disease

Genetic Tests for Upper Respiratory Tract Disease

Anatomical Context for Upper Respiratory Tract Disease

MalaCards organs/tissues related to Upper Respiratory Tract Disease:

40
Bone, Skin, Thyroid, B Cells, Colon, Lung, Cervix

Publications for Upper Respiratory Tract Disease

Articles related to Upper Respiratory Tract Disease:

(show top 50) (show all 278)
# Title Authors PMID Year
1
Validation of specific quantitative real-time RT-PCR assay panel for Infectious Bronchitis using synthetic DNA standards and clinical specimens. 61
31712094 2020
2
The clinical benefit of instituting a prospective clinical community-acquired respiratory virus surveillance program in allogeneic hematopoietic stem cell transplantation. 61
31972212 2020
3
Multiple Correspondence Analysis on Amino Acid Properties within the Variable Region of the Capsid Protein Shows Differences between Classical and Virulent Systemic Feline Calicivirus Strains. 61
31771183 2019
4
Cat flu: Broad spectrum polymeric antivirals. 61
31325462 2019
5
Detection of multidrug resistance and extended-spectrum/plasmid-mediated AmpC beta-lactamase genes in Enterobacteriaceae isolates from diseased cats in Italy. 61
31524037 2019
6
A QUANTITATIVE PCR ASSAY FOR A MYCOPLASMA FROM EMYDID TURTLES INDICATES HIGH PREVALENCE IN HEALTHY THREE-TOED BOX TURTLES (TERRAPENE CAROLINA TRIUNGUIS) FROM MISSOURI, USA. 61
30822209 2019
7
Effects of famciclovir in cats with spontaneous acute upper respiratory tract disease. 61
31246133 2019
8
[Treatment of acute viral feline upper respiratory tract infections]. 61
31013527 2019
9
Antimicrobial use for selected diseases in cats in Switzerland. 61
30871537 2019
10
Investigation onto the correlation between systemic antibodies to surface glycoproteins of infectious laryngotracheitis virus (ILTV) and protective immunity. 61
30593375 2019
11
Upper respiratory tract disease and associated diagnostic tests of mycoplasmosis in Alabama populations of Gopher tortoises, Gopherus polyphemus. 61
30951541 2019
12
Genomic sequence and pathogenicity of the first avian metapneumovirus subtype B isolated from chicken in China. 61
30593377 2019
13
Investigation of a Large-Scale Gopher Tortoise ( Gopherus polyphemus) Mortality Event on a Public Conservation Land in Florida, USA. 61
29792758 2018
14
The slow dynamics of mycoplasma infections in a tortoise host reveal heterogeneity pertinent to pathogen transmission and monitoring. 61
30251621 2018
15
Potential Therapeutic Agents for Feline Calicivirus Infection. 61
30115859 2018
16
Calicivirus co-infections in herpesvirus pneumonia in kittens. 61
29871741 2018
17
Transcutaneous immunization with pneumococcal surface protein A in mice. 61
29226330 2018
18
Infectious Laryngotracheitis Virus Viral Chemokine-Binding Protein Glycoprotein G Alters Transcription of Key Inflammatory Mediators In Vitro and In Vivo. 61
29070686 2018
19
Determination of the minimum protective dose of a glycoprotein-G-deficient infectious laryngotracheitis virus vaccine delivered via eye-drop to week-old chickens. 61
30521554 2018
20
Identifying genome-wide immune gene variation underlying infectious disease in wildlife populations - a next generation sequencing approach in the gopher tortoise. 61
29351737 2018
21
Lateral rhinostomy for treatment of severe chronic rhinosinusitis in two rabbits. 61
29244604 2018
22
High quality draft genome sequences of Mycoplasma agassizii strains PS6T and 723 isolated from Gopherus tortoises with upper respiratory tract disease. 61
29725499 2018
23
High quality draft genome sequence of Mycoplasma testudineum strain BH29T, isolated from the respiratory tract of a desert tortoise. 61
29682170 2018
24
[Nasal irrigation: opportunities and disadvantages]. 61
30721193 2018
25
Chronic disease in the Mojave desert tortoise: Host physiology and recrudescence obscure patterns of pathogen transmission. 61
29299243 2017
26
Co-infection does not predict disease signs in Gopherus tortoises. 61
29134096 2017
27
Isolation and phylogenetic analysis of three feline calicivirus strains from domestic cats in Jilin Province, China. 61
28478577 2017
28
Respiratory viruses in transplant recipients: more than just a cold. Clinical syndromes and infection prevention principles. 61
28739424 2017
29
MOLECULAR DETECTION OF INFECTIOUS PATHOGENS OF THE UPPER RESPIRATORY TRACT IN CAPTIVE NONDOMESTIC FELIDS. 61
28749292 2017
30
Evaluation of the ERIC-PCR as a probable method to differentiate Avibacterium paragallinarum serovars. 61
27866411 2017
31
Prevalence of feline herpesvirus-1, feline calicivirus, Chlamydophila felis and Mycoplasma felis DNA and associated risk factors in cats in Spain with upper respiratory tract disease, conjunctivitis and/or gingivostomatitis. 61
26919892 2017
32
Recombinase Polymerase Amplification Assay-A Simple, Fast and Cost-Effective Alternative to Real Time PCR for Specific Detection of Feline Herpesvirus-1. 61
28045956 2017
33
Bacterial microbiome in the nose of healthy cats and in cats with nasal disease. 61
28662139 2017
34
Genetic characterization of equine herpesvirus 1 isolates from abortion outbreaks in India. 61
27699511 2017
35
Upper Respiratory Tract Diseases in Athletes in Different Sports Disciplines. 61
28149415 2016
36
Occurrence of Chlamydophila felis, feline herpesvirus 1 and calcivirus in domestic cats of Iran. 61
28149490 2016
37
Evaluation of intranasal vaccine administration and high-dose interferon- α2b therapy for treatment of chronic upper respiratory tract infections in shelter cats. 61
26269455 2016
38
Chlamydia felis: Lack of association between clinical signs and the presence of the cryptic plasmid. 61
27208751 2016
39
Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease. 61
27166137 2016
40
Equine herpesvirus-1 infection disrupts interferon regulatory factor-3 (IRF-3) signaling pathways in equine endothelial cells. 61
27090619 2016
41
Clinical Mycoplasma sp. Infections in Free-living Three-toed Box Turtles ( Terrapene carolina triunguis) in Missouri, USA. 61
27124328 2016
42
Serological prevalence of human parvovirus B19 in diseases or disordersrelated to different human body systems. 61
27511498 2016
43
European molecular epidemiology and strain diversity of feline calicivirus. 61
26811440 2016
44
The relationship between serum vitamin D and chronic rhinosinusitis: A systematic review. 61
26867526 2016
45
Antiviral effect of lithium chloride on feline calicivirus in vitro. 61
26239340 2015
46
Ability of vaccine strain induced antibodies to neutralize field isolates of caliciviruses from Swedish cats. 61
26655039 2015
47
Sampling sites for detection of feline herpesvirus-1, feline calicivirus and Chlamydia felis in cats with feline upper respiratory tract disease. 61
25660223 2015
48
Detection of feline upper respiratory tract disease pathogens using a commercially available real-time PCR test. 61
26324635 2015
49
Feline calicivirus and other respiratory pathogens in cats with Feline calicivirus-related symptoms and in clinically healthy cats in Switzerland. 61
26566897 2015
50
A review of traditional and contemporary assays for direct and indirect detection of Equid herpesvirus 1 in clinical samples. 61
26472746 2015

Variations for Upper Respiratory Tract Disease

Expression for Upper Respiratory Tract Disease

Search GEO for disease gene expression data for Upper Respiratory Tract Disease.

Pathways for Upper Respiratory Tract Disease

Pathways related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 MIR9-1 MIR34C MIR30A MIR29C MIR27A MIR21
2 11.38 MIR34C MIR30A MIR20A MIR17
3 10.96 MIR93 MIR34C MIR27A MIR106B

GO Terms for Upper Respiratory Tract Disease

Cellular components related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.47 MIR93 MIR744 MIR30A MIR29C MIR27A MIR21

Biological processes related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.91 MIR29C MIR27A MIR21 MIR20A MIR185 MIR17
2 positive regulation of angiogenesis GO:0045766 9.88 MIR30A MIR21 MIR20A MIR199A1 MIR143
3 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.76 MIR27A MIR21 MIR20A MIR17
4 negative regulation of protein kinase B signaling GO:0051898 9.74 MIR34C MIR29C MIR20A
5 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.73 MIR21 MIR20A MIR199A1 MIR106B
6 negative regulation of angiogenesis GO:0016525 9.73 MIR29C MIR21 MIR185 MIR143 MIR125A MIR106B
7 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.71 MIR29C MIR20A MIR196A1
8 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.7 MIR27A MIR20A MIR196A1
9 negative regulation of sprouting angiogenesis GO:1903671 9.69 MIR34C MIR20A MIR17
10 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.67 MIR21 MIR20A MIR143
11 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.62 MIR27A MIR199A1 MIR185 MIR17
12 positive regulation of connective tissue replacement GO:1905205 9.58 MIR34C MIR199A1
13 positive regulation of metalloendopeptidase activity GO:1904685 9.58 MIR21 MIR17
14 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.58 MIR20A MIR17 MIR143
15 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.56 MIR21 MIR17
16 negative regulation of low-density lipoprotein receptor activity GO:1905598 9.55 MIR27A MIR185
17 miRNA mediated inhibition of translation GO:0035278 9.5 MIR9-1 MIR30A MIR27A MIR21 MIR20A MIR17
18 gene silencing by miRNA GO:0035195 9.5 MIR106B MIR125A MIR143 MIR17 MIR185 MIR196A1
19 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.46 MIR34C MIR20A MIR199A1 MIR17

Molecular functions related to Upper Respiratory Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.47 MIR93 MIR9-1 MIR30A MIR29C MIR27A MIR21

Sources for Upper Respiratory Tract Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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