MCID: URC003
MIFTS: 35

Urachal Adenocarcinoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Urachal Adenocarcinoma

MalaCards integrated aliases for Urachal Adenocarcinoma:

Name: Urachal Adenocarcinoma 54 74
Adenocarcinoma of the Urachus 54

Classifications:



External Ids:

UMLS 74 C2931201

Summaries for Urachal Adenocarcinoma

MalaCards based summary : Urachal Adenocarcinoma, also known as adenocarcinoma of the urachus, is related to adenocarcinoma and ovarian cystadenocarcinoma. An important gene associated with Urachal Adenocarcinoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Pathways in cancer and Beta-Adrenergic Signaling. Affiliated tissues include ovary, colon and testis, and related phenotypes are Decreased cell migration and Increased cell migration

Related Diseases for Urachal Adenocarcinoma

Diseases related to Urachal Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 31.0 BRAF GNAS KRAS
2 ovarian cystadenocarcinoma 30.0 GNAS KRAS
3 colorectal adenocarcinoma 29.7 BRAF CEACAM5 KRAS
4 bladder urachal adenocarcinoma 12.3
5 mucinous adenocarcinoma 10.5
6 appendix adenocarcinoma 10.5
7 degos 'en cocarde' erythrokeratoderma 10.3
8 mucinous cystadenofibroma 10.2 AFP CEACAM5
9 liver lymphoma 10.2 AFP CEACAM5
10 melanotic medulloblastoma 10.2 AFP CEACAM5
11 hematocele of tunica vaginalis testis 10.2 AFP CEACAM5
12 bile duct cystadenocarcinoma 10.2 AFP CEACAM5
13 liver sarcoma 10.1 AFP CEACAM5
14 rete testis adenocarcinoma 10.1 AFP CEACAM5
15 rete testis neoplasm 10.1 AFP CEACAM5
16 hyperplastic polyposis syndrome 10.1 BRAF KRAS
17 epidermolysis bullosa, junctional, herlitz type 10.1 AFP CEACAM5
18 extragonadal seminoma 10.1 AFP CEACAM5
19 mixed cell type cancer 10.1 AFP CEACAM5
20 sigmoid neoplasm 10.1 CEACAM5 KRAS
21 signet ring cell adenocarcinoma 10.1
22 apocrine adenoma 10.1 CEACAM5 KRAS
23 tracheal cancer 10.1 AFP CEACAM5
24 testicular yolk sac tumor 10.1 AFP CEACAM5
25 aggressive digital papillary adenocarcinoma 10.1 CEACAM5 KRAS
26 biliary papillomatosis 10.1 CEACAM5 KRAS
27 bile duct disease 10.1 AFP CEACAM5
28 gastrointestinal system benign neoplasm 10.0 CEACAM5 KRAS
29 ovary adenocarcinoma 10.0 CEACAM5 KRAS
30 intestinal benign neoplasm 10.0 CEACAM5 KRAS
31 cardiofaciocutaneous syndrome 1 10.0 BRAF KRAS
32 biliary tract disease 10.0 AFP CEACAM5
33 sex cord-gonadal stromal tumor 10.0 AFP GNAS
34 appendix disease 10.0 GNAS KRAS
35 ovarian cancer 1 10.0 CEACAM5 KRAS
36 malignant ovarian surface epithelial-stromal neoplasm 10.0 CEACAM5 KRAS
37 testicular germ cell tumor 10.0 AFP BRAF
38 ovary epithelial cancer 10.0 CEACAM5 KRAS
39 leukemia, chronic lymphocytic 2 10.0 BRAF KRAS
40 hepatoid adenocarcinoma 10.0
41 papillary adenocarcinoma 10.0
42 lymphoma 9.9
43 dermatomyositis 9.9
44 bladder lymphoma 9.9
45 cystadenocarcinoma 9.9
46 pseudomyxoma peritonei 9.9
47 mucinous cystadenocarcinoma 9.9
48 breast mucinous carcinoma 9.9
49 adenocarcinoma in situ 9.9
50 appendicitis 9.9

Graphical network of the top 20 diseases related to Urachal Adenocarcinoma:



Diseases related to Urachal Adenocarcinoma

Symptoms & Phenotypes for Urachal Adenocarcinoma

GenomeRNAi Phenotypes related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.33 BRAF KRAS NF1
2 Increased cell migration GR00055-A-3 9.13 BRAF KRAS NF1
3 Reduced mammosphere formation GR00396-S 8.92 AFP BRAF GNAS KRAS

MGI Mouse Phenotypes related to Urachal Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.85 AFP BRAF GNAS KRAS NF1
2 craniofacial MP:0005382 9.78 BRAF GNAS KRAS NF1
3 liver/biliary system MP:0005370 9.77 AFP BRAF GNAS KRAS NF1
4 hearing/vestibular/ear MP:0005377 9.73 BRAF GNAS KRAS NF1
5 limbs/digits/tail MP:0005371 9.71 BRAF GNAS KRAS NF1
6 neoplasm MP:0002006 9.65 AFP BRAF GNAS KRAS NF1
7 muscle MP:0005369 9.62 BRAF GNAS KRAS NF1
8 pigmentation MP:0001186 9.33 BRAF KRAS NF1
9 renal/urinary system MP:0005367 9.26 BRAF GNAS KRAS NF1
10 respiratory system MP:0005388 8.92 BRAF GNAS KRAS NF1

Drugs & Therapeutics for Urachal Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Urachal Adenocarcinoma

Genetic Tests for Urachal Adenocarcinoma

Anatomical Context for Urachal Adenocarcinoma

MalaCards organs/tissues related to Urachal Adenocarcinoma:

42
Ovary, Colon, Testis, Thyroid, Appendix, Brain, Lymph Node

Publications for Urachal Adenocarcinoma

Articles related to Urachal Adenocarcinoma:

(show top 50) (show all 112)
# Title Authors Year
1
Germline BRCA1 Deletion as Driver Mutation for Metastatic Urachal Adenocarcinoma in Patient Who Achieved Complete Response to Rucaparib. ( 30939057 )
2019
2
Invasive non-urachal adenocarcinoma of the bladder: analysis of the National Cancer Database. ( 30030660 )
2019
3
Urachal adenocarcinoma. ( 30219781 )
2018
4
Urachal Adenocarcinoma: A Case Report with Key Imaging Findings and Radiologic-Pathologic Correlation. ( 29682385 )
2018
5
Urachal adenocarcinoma: a rare case report. ( 28228881 )
2017
6
Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma. ( 28285720 )
2017
7
Response to: Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma. ( 28666639 )
2017
8
Response to: Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma: author reply. ( 28666644 )
2017
9
Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma: A rare case report and literature review. ( 27583877 )
2016
10
Hepatoid Adenocarcinoma of the Urachus. ( 27803830 )
2016
11
Urachal Adenocarcinoma in a Dog. ( 27009748 )
2016
12
Whole exome sequencing of urachal adenocarcinoma reveals recurrent NF1 mutations. ( 27078850 )
2016
13
Fine Needle Aspiration Cytology Diagnosis of an Urachal Adenocarcinoma. ( 27190817 )
2016
14
Urachal adenocarcinoma incidentally discovered in a young woman at elective caesarean section. ( 27353172 )
2016
15
Extended partial cystectomy with augmentation cystoplasty in urachal adenocarcinoma: An oncologically favorable but underutilized alternative to radical cystectomy. ( 27453665 )
2016
16
Rare presentation of urachal adenocarcinoma with skip metastasis to colon. ( 27555687 )
2016
17
A comprehensive review of pediatric urachal anomalies and predictive analysis for adult urachal adenocarcinoma. ( 25219697 )
2015
18
Unusual presentation of urachal adenocarcinoma with genitourinary cutaneous metastasis. ( 25337842 )
2015
19
En Bloc Robot-assisted Laparoscopic Partial Cystectomy, Urachal Resection, and Pelvic Lymphadenectomy for Urachal Adenocarcinoma. ( 26029004 )
2015
20
Bladder sparing robot-assisted laparoscopic en bloc resection of urachus and umbilicus for urachal adenocarcinoma. ( 26531120 )
2015
21
Robotic Partial Cystectomy for Primary Urachal Adenocarcinoma of the Urinary Bladder. ( 30263024 )
2015
22
[Urachal adenocarcinoma of the bladder, our experience in 20 years]. ( 25774825 )
2015
23
High-stage urachal adenocarcinoma can be associated with microsatellite instability and KRAS mutations. ( 24355196 )
2014
24
18FDG PET/CT findings in the unusual urachal adenocarcinoma. ( 24566402 )
2014
25
Response to targeted therapy in urachal adenocarcinoma. ( 25568747 )
2014
26
Outcomes of Korean patients with clinically localized urachal or non-urachal adenocarcinoma of the bladder. ( 21458312 )
2013
27
A rare cause of urachal adenocarcinoma: urachal diverticle. ( 23476880 )
2013
28
The different morphologies of urachal adenocarcinoma do not discriminate genomically by micro-RNA expression profiling. ( 23528864 )
2013
29
A rare case of recurrent urachal adenocarcinoma of the bladder. ( 23914577 )
2013
30
Combined modalities treatment of pulmonary metastasis from an urachal adenocarcinoma. ( 24179644 )
2013
31
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for patients with peritoneal carcinomatosis secondary to urachal adenocarcinoma. ( 22271499 )
2012
32
A case of metastatic urachal adenocarcinoma treated with several different chemotherapeutic regimens. ( 22396380 )
2012
33
Urachal adenocarcinoma. Case report and bibliographic review. ( 22619143 )
2012
34
Urachal adenocarcinoma: big dimensions without involvement of the bladder wall. ( 22641501 )
2012
35
Urachal adenocarcinoma: a clinician's guide for treatment. ( 23040259 )
2012
36
Prostatic urethral recurrence of urachal adenocarcinoma. ( 21900110 )
2011
37
Papillary adenocarcinoma of the urachus presenting as an umbilical mass. ( 20648839 )
2010
38
Alpha-methylacyl-coenzyme a racemase-expressing urachal adenocarcinoma of the abdominal wall. ( 20664785 )
2010
39
Urachal adenocarcinoma with late brain metastases. ( 20945591 )
2010
40
Urachal adenocarcinoma metastatic to the ovaries resembling primary ovarian mucinous carcinoma: a case report with the immunohistochemical study. ( 21228934 )
2010
41
Robotic-assisted partial cystectomy with en bloc excision of the urachus and the umbilicus for urachal adenocarcinoma. ( 27628636 )
2010
42
Laparoscopic treatment of mucinous urachal adenocarcinoma with mucocele. ( 19238053 )
2009
43
Urachal adenocarcinoma following kidney transplantation: the first case report. ( 19545760 )
2009
44
Enteric type urachal adenocarcinoma: a case report. ( 19671231 )
2009
45
Robotic assisted laparoscopic partial cystectomy and urachal resection for urachal adenocarcinoma. ( 19860941 )
2009
46
Treatment of metastatic urachal adenocarcinoma in a young woman: a case report. ( 20062662 )
2009
47
Urachal adenocarcinoma. ( 18554640 )
2008
48
Urachal adenocarcinoma masquerading as an urachal cyst. ( 23133041 )
2008
49
Preliminary report of multimodal treatment with ifosfamide, 5-fluorouracil, etoposide and cisplatin (IFEP chemotherapy) against metastatic adenocarcinoma of the urachus. ( 18786207 )
2008
50
Laparoscopic partial cystectomy with en bloc resection of the urachus for urachal adenocarcinoma. ( 17880303 )
2007

Variations for Urachal Adenocarcinoma

Expression for Urachal Adenocarcinoma

Search GEO for disease gene expression data for Urachal Adenocarcinoma.

Pathways for Urachal Adenocarcinoma

Pathways related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1 12.56 BRAF GNAS KRAS
2
Show member pathways
12.52 BRAF GNAS KRAS
3 12.49 BRAF KRAS NF1
4
Show member pathways
12.45 BRAF GNAS KRAS
5
Show member pathways
12.38 BRAF GNAS KRAS
6
Show member pathways
12.38 BRAF GNAS KRAS
7
Show member pathways
12.15 BRAF GNAS KRAS NF1
8
Show member pathways
12.11 BRAF KRAS NF1
9
Show member pathways
11.99 BRAF KRAS NF1
10
Show member pathways
11.9 BRAF GNAS KRAS NF1
11
Show member pathways
11.87 BRAF GNAS KRAS
12 11.85 BRAF GNAS KRAS
13 11.8 BRAF KRAS NF1
14
Show member pathways
11.71 BRAF KRAS NF1
15 11.6 BRAF GNAS KRAS
16
Show member pathways
11.57 BRAF KRAS
17 11.55 BRAF KRAS NF1
18 11.51 BRAF KRAS
19 11.47 BRAF GNAS
20
Show member pathways
11.44 BRAF KRAS
21 11.44 BRAF GNAS KRAS
22 11.38 BRAF KRAS NF1
23 11.3 BRAF GNAS
24 11.29 BRAF NF1
25 11.28 KRAS NF1
26 11.23 AFP NF1
27 11.22 BRAF KRAS
28 11.11 BRAF GNAS KRAS
29 11.1 BRAF KRAS
30 10.97 BRAF KRAS
31 10.89 BRAF GNAS
32 10.77 BRAF GNAS
33 10.58 BRAF GNAS KRAS

GO Terms for Urachal Adenocarcinoma

Biological processes related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.5 BRAF KRAS NF1
2 liver development GO:0001889 9.43 KRAS NF1
3 Ras protein signal transduction GO:0007265 9.4 KRAS NF1
4 cognition GO:0050890 9.37 GNAS NF1
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.26 KRAS NF1
6 regulation of synaptic transmission, GABAergic GO:0032228 9.16 KRAS NF1
7 visual learning GO:0008542 9.13 BRAF KRAS NF1
8 forebrain astrocyte development GO:0021897 8.62 KRAS NF1

Sources for Urachal Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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