MCID: URC003
MIFTS: 31

Urachal Adenocarcinoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Urachal Adenocarcinoma

MalaCards integrated aliases for Urachal Adenocarcinoma:

Name: Urachal Adenocarcinoma 20 70
Adenocarcinoma of the Urachus 20

Classifications:



External Ids:

UMLS 70 C2931201

Summaries for Urachal Adenocarcinoma

MalaCards based summary : Urachal Adenocarcinoma, also known as adenocarcinoma of the urachus, is related to appendix adenocarcinoma and mucinous adenocarcinoma. An important gene associated with Urachal Adenocarcinoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are MAPK signaling pathway and G-AlphaQ Signaling. Affiliated tissues include colon, ovary and breast, and related phenotypes are Decreased cell migration and Reduced mammosphere formation

Related Diseases for Urachal Adenocarcinoma

Diseases related to Urachal Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 appendix adenocarcinoma 30.4 KRAS GNAS
2 mucinous adenocarcinoma 30.3 KRAS CEACAM5
3 tubular adenocarcinoma 30.0 CEACAM5 AFP
4 colorectal adenocarcinoma 29.8 KRAS CEACAM5 BRAF
5 adenocarcinoma 29.8 KRAS GNAS CEACAM5 BRAF
6 papillary adenocarcinoma 29.8 KRAS CEACAM5
7 signet ring cell adenocarcinoma 29.6 KRAS CEACAM5
8 adenocarcinoma in situ 29.6 KRAS CEACAM5
9 cystadenoma 29.6 GNAS CEACAM5 AFP
10 adenoma 29.5 KRAS GNAS BRAF
11 pseudomyxoma peritonei 29.3 KRAS GNAS CEACAM5
12 ovarian cystadenocarcinoma 29.3 KRAS GNAS CEACAM5
13 villous adenoma 29.3 KRAS GNAS CEACAM5 BRAF
14 bladder urachal adenocarcinoma 11.3
15 rare tumor 10.3
16 bladder adenocarcinoma 10.3
17 bladder urachal carcinoma 10.3
18 nonseminomatous germ cell tumor 10.2 BRAF AFP
19 tethered spinal cord syndrome 10.2 BRAF AFP
20 liver lipoma 10.2 CEACAM5 AFP
21 bladder cancer 10.1
22 breast mucinous carcinoma 10.1
23 gestational ovarian choriocarcinoma 10.1 CEACAM5 AFP
24 liver inflammatory pseudotumor 10.1 CEACAM5 AFP
25 rectum signet ring adenocarcinoma 10.1 CEACAM5 AFP
26 adult teratoma 10.1 CEACAM5 AFP
27 dermoid cyst of ovary 10.1 CEACAM5 AFP
28 renal pelvis adenocarcinoma 10.1 CEACAM5 AFP
29 bile duct cystadenocarcinoma 10.1 CEACAM5 AFP
30 epididymal neoplasm 10.1 NF1 AFP
31 colonic lymphangioma 10.1 CEACAM5 AFP
32 paratesticular lipoma 10.1 CEACAM5 AFP
33 lipoma of spermatic cord 10.1 CEACAM5 AFP
34 liver leiomyoma 10.1 CEACAM5 AFP
35 esophageal adenoid cystic carcinoma 10.1 CEACAM5 AFP
36 ovarian mixed germ cell neoplasm 10.1 CEACAM5 AFP
37 liver sarcoma 10.1 CEACAM5 AFP
38 sarcomatous intrahepatic cholangiocarcinoma 10.1 CEACAM5 AFP
39 common bile duct disease 10.1 CEACAM5 AFP
40 abdominal tuberculosis 10.1 CEACAM5 AFP
41 mediastinal cancer 10.1 CEACAM5 AFP
42 ovarian benign neoplasm 10.1 CEACAM5 AFP
43 intrahepatic bile duct adenoma 10.1 CEACAM5 AFP
44 klatskin's tumor 10.1 CEACAM5 AFP
45 ovarian germ cell cancer 10.1 CEACAM5 AFP
46 malignant teratoma 10.1 CEACAM5 AFP
47 pilocytic astrocytoma of cerebellum 10.1 NF1 BRAF
48 ovarian cyst 10.1 GNAS AFP
49 hepatic tuberculosis 10.1 CEACAM5 AFP
50 cerebellar astrocytoma 10.1 NF1 BRAF

Graphical network of the top 20 diseases related to Urachal Adenocarcinoma:



Diseases related to Urachal Adenocarcinoma

Symptoms & Phenotypes for Urachal Adenocarcinoma

GenomeRNAi Phenotypes related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-3 8.96 BRAF
2 Reduced mammosphere formation GR00396-S 8.92 AFP BRAF GNAS KRAS

MGI Mouse Phenotypes related to Urachal Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.72 AFP BRAF GNAS KRAS NF1
2 hearing/vestibular/ear MP:0005377 9.56 BRAF GNAS KRAS NF1
3 limbs/digits/tail MP:0005371 9.46 BRAF GNAS KRAS NF1
4 liver/biliary system MP:0005370 9.35 AFP BRAF GNAS KRAS NF1
5 neoplasm MP:0002006 9.02 AFP BRAF GNAS KRAS NF1

Drugs & Therapeutics for Urachal Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Urachal Adenocarcinoma

Genetic Tests for Urachal Adenocarcinoma

Anatomical Context for Urachal Adenocarcinoma

MalaCards organs/tissues related to Urachal Adenocarcinoma:

40
Colon, Ovary, Breast, Liver, Thyroid, Skin, Appendix

Publications for Urachal Adenocarcinoma

Articles related to Urachal Adenocarcinoma:

(show top 50) (show all 238)
# Title Authors PMID Year
1
Urachal carcinoma revealed by isolated hematuria. 61
33732451 2021
2
Urachal adenocarcinoma. Analysis of 8 years in a third level medical facility. 61
33498072 2021
3
Survival of contemporary patients with non-metastatic urachal vs. non-urachal adenocarcinoma of the urinary bladder. 61
31960108 2020
4
Mucinous urachal adenocarcinoma: A potential nonfluorodeoxyglucose-avid pitfall on 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography. 61
33623517 2020
5
Comparative genomic profiling of glandular bladder tumours. 61
32198650 2020
6
Molecular Genetic Features of Primary Nonurachal Enteric-type Adenocarcinoma, Urachal Adenocarcinoma, Mucinous Adenocarcinoma, and Intestinal Metaplasia/Adenoma: Review of the Literature and Next-generation Sequencing Study. 61
32520749 2020
7
Villous adenoma of the urachus obscuring urachal adenocarcinoma: A case report. 61
32477881 2020
8
Successful surgical management of recurrent urachal adenocarcinoma: A case report. 61
32322529 2020
9
Clinical utility of 18F-FDG PET/CT in staging and treatment planning of urachal adenocarcinoma. 61
32948680 2020
10
Diagnostic Laparoscopy and Abdominal Cytology Reliably Detect Peritoneal Metastases in Patients with Urachal Adenocarcinoma. 61
32052302 2020
11
U-shaped relationship of age at diagnosis and cancer-specific mortality in primary urachal adenocarcinoma: a cohort study. 61
32676391 2020
12
Ex vivo modelling of drug efficacy in a rare metastatic urachal carcinoma. 61
32576176 2020
13
Excision and Reconstruction for Urachal Adenocarcinoma: A Case Report With an Emphasis on Cosmesis. 61
32087210 2020
14
Mutational Profile Using Next-Generation Sequencing May Aid in the Diagnosis and Treatment of Urachal Adenocarcinoma. 61
31496327 2020
15
Urachal adenocarcinoma surgical management - Emphasis on enbloc umbilectomy and urachal remnant excision with negative margins. 61
31641616 2020
16
Successful treatment of locally advanced urachal adenocarcinoma with peri-operative gemcitabine - cisplatin combination therapy: a case report and perspective on targeted therapies. 61
33552573 2020
17
Current Understanding of Urachal Adenocarcinoma and Management Strategy. 61
31989430 2020
18
Radical cystoprostatectomy to treat urachal carcinoma. 61
31656427 2019
19
Long-term survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with peritoneal metastases of urachal cancer. 61
31003721 2019
20
Metastatic urachal cancer treated effectively with gemcitabine/cisplatin combination chemotherapy and radiotherapy: A case report. 61
31281647 2019
21
Cisplatin and S-1 for urachal carcinoma: A single-institution case series. 61
32743398 2019
22
Germline BRCA1 Deletion as Driver Mutation for Metastatic Urachal Adenocarcinoma in Patient Who Achieved Complete Response to Rucaparib. 61
30939057 2019
23
Invasive non-urachal adenocarcinoma of the bladder: analysis of the National Cancer Database. 61
30030660 2019
24
Surgical management of urachal tumors: Can the umbilicus be sparred in localized disease? 61
31105920 2019
25
Brain metastasis from urachal carcinoma. 61
31528487 2019
26
Non-urothelial carcinomas of the bladder. 61
30565306 2019
27
Imaging Features of Urachal Cancer: A Case Report. 61
31850195 2019
28
Urachal mucinous adenocarcinoma in the pelvic wall mimicking endometriosis. 61
30108674 2018
29
Urachal adenocarcinoma. 61
30219781 2018
30
Retrospective analysis of palliative chemotherapy for the patients with bladder adenocarcinoma: Korean Cancer Study Group Genitourinary and Gynecology Cancer Committee. 61
27048257 2018
31
Urachal Adenocarcinoma: A Case Report with Key Imaging Findings and Radiologic-Pathologic Correlation. 61
29682385 2018
32
Telomerase reverse transcriptase (TERT) promoter mutations are rare in urachal cancer. 61
29047227 2017
33
Total Mesenteric Peritonectomy for Peritoneal Metastases (with video). 61
28986751 2017
34
Response to: Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma: author reply. 61
28666644 2017
35
Response to: Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma. 61
28666639 2017
36
Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma. 61
28285720 2017
37
Urachal adenocarcinoma: a rare case report. 61
28228881 2017
38
"Look Before You Leap": Urachal Mass in Adults. 61
28983381 2017
39
Comprehensive Molecular Characterization of Urachal Adenocarcinoma Reveals Commonalities With Colorectal Cancer, Including a Hypermutable Phenotype. 61
32913973 2017
40
Erratum: Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma: A rare case report and literature review: Erratum. 61
31305695 2017
41
Urachal carcinoma: Report of two cases and review of the literature. 61
28123739 2017
42
Erratum: The malignant transformation of retrorectal cystic hamartomas with blood irregular antibodies positive: A case report: Erratum Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma: A rare case report and literature review: Erratum. 61
31265672 2016
43
Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma: A rare case report and literature review. 61
27583877 2016
44
Extended partial cystectomy with augmentation cystoplasty in urachal adenocarcinoma: An oncologically favorable but underutilized alternative to radical cystectomy. 61
27453665 2016
45
Rare presentation of urachal adenocarcinoma with skip metastasis to colon. 61
27555687 2016
46
Urachal adenocarcinoma incidentally discovered in a young woman at elective caesarean section. 61
27353172 2016
47
Urachal Adenocarcinoma in a Dog. 61
27009748 2016
48
Whole exome sequencing of urachal adenocarcinoma reveals recurrent NF1 mutations. 61
27078850 2016
49
[Mucinous adenocarcinoma of the Urachus: A Case Report]. 61
26910316 2016
50
Fine Needle Aspiration Cytology Diagnosis of an Urachal Adenocarcinoma. 61
27190817 2016

Variations for Urachal Adenocarcinoma

Expression for Urachal Adenocarcinoma

Search GEO for disease gene expression data for Urachal Adenocarcinoma.

Pathways for Urachal Adenocarcinoma

Pathways related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1 12.51 NF1 KRAS BRAF
2
Show member pathways
12.41 KRAS GNAS BRAF
3
Show member pathways
12.4 KRAS GNAS BRAF
4
Show member pathways
12.39 KRAS GNAS BRAF
5
Show member pathways
12.23 NF1 KRAS BRAF
6
Show member pathways
12.22 KRAS GNAS BRAF
7
Show member pathways
12.11 NF1 KRAS BRAF
8
Show member pathways
12.1 NF1 KRAS GNAS BRAF
9
Show member pathways
12.01 NF1 KRAS BRAF
10 11.89 KRAS GNAS BRAF
11 11.86 KRAS GNAS BRAF
12
Show member pathways
11.86 NF1 KRAS GNAS BRAF
13 11.82 NF1 KRAS BRAF
14
Show member pathways
11.74 NF1 KRAS BRAF
15 11.64 KRAS GNAS BRAF
16 11.6 NF1 KRAS BRAF
17 11.54 KRAS BRAF
18 11.54 NF1 KRAS BRAF
19 11.53 KRAS BRAF
20 11.5 KRAS BRAF
21 11.49 GNAS BRAF
22 11.48 KRAS BRAF
23 11.47 KRAS GNAS BRAF
24
Show member pathways
11.47 KRAS GNAS BRAF
25
Show member pathways
11.46 KRAS BRAF
26
Show member pathways
11.39 KRAS BRAF
27 11.33 GNAS BRAF
28 11.32 NF1 BRAF
29 11.3 NF1 KRAS
30
Show member pathways
11.3 NF1 BRAF
31 11.26 NF1 AFP
32 11.24 KRAS BRAF
33 11.18 KRAS BRAF
34 11.09 KRAS BRAF
35 10.99 KRAS BRAF
36 10.9 GNAS BRAF
37 10.79 GNAS BRAF
38 10.58 KRAS GNAS BRAF

GO Terms for Urachal Adenocarcinoma

Biological processes related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.33 NF1 KRAS BRAF
2 Ras protein signal transduction GO:0007265 9.32 NF1 KRAS
3 cognition GO:0050890 9.26 NF1 GNAS
4 visual learning GO:0008542 9.13 NF1 KRAS BRAF
5 forebrain astrocyte development GO:0021897 8.62 NF1 KRAS

Sources for Urachal Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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