MCID: URC003
MIFTS: 35

Urachal Adenocarcinoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Urachal Adenocarcinoma

MalaCards integrated aliases for Urachal Adenocarcinoma:

Name: Urachal Adenocarcinoma 54 74
Adenocarcinoma of the Urachus 54

Classifications:



External Ids:

UMLS 74 C2931201

Summaries for Urachal Adenocarcinoma

MalaCards based summary : Urachal Adenocarcinoma, also known as adenocarcinoma of the urachus, is related to adenocarcinoma and colorectal adenocarcinoma. An important gene associated with Urachal Adenocarcinoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Pathways in cancer and Beta-Adrenergic Signaling. Affiliated tissues include ovary, colon and breast, and related phenotypes are Decreased cell migration and Increased cell migration

Related Diseases for Urachal Adenocarcinoma

Diseases related to Urachal Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 31.2 BRAF GNAS KRAS
2 colorectal adenocarcinoma 29.8 BRAF CEACAM5 KRAS
3 bladder urachal adenocarcinoma 12.2
4 mucinous adenocarcinoma 10.5
5 degos 'en cocarde' erythrokeratoderma 10.3
6 hyperplastic polyposis syndrome 10.2 BRAF KRAS
7 sigmoid neoplasm 10.1 CEACAM5 KRAS
8 apocrine adenoma 10.1 CEACAM5 KRAS
9 aggressive digital papillary adenocarcinoma 10.1 CEACAM5 KRAS
10 appendix disease 10.1 GNAS KRAS
11 signet ring cell adenocarcinoma 10.1
12 ovarian cystadenocarcinoma 10.1 GNAS KRAS
13 biliary papillomatosis 10.1 CEACAM5 KRAS
14 cardiofaciocutaneous syndrome 1 10.1 BRAF KRAS
15 gastrointestinal system benign neoplasm 10.1 CEACAM5 KRAS
16 ovary adenocarcinoma 10.1 CEACAM5 KRAS
17 intestinal benign neoplasm 10.1 CEACAM5 KRAS
18 ovarian cancer 1 10.1 CEACAM5 KRAS
19 malignant ovarian surface epithelial-stromal neoplasm 10.1 CEACAM5 KRAS
20 mucinous cystadenofibroma 10.0 AFP CEACAM5
21 leukemia, chronic lymphocytic 2 10.0 BRAF KRAS
22 liver lymphoma 10.0 AFP CEACAM5
23 ovary epithelial cancer 10.0 CEACAM5 KRAS
24 melanotic medulloblastoma 10.0 AFP CEACAM5
25 hematocele of tunica vaginalis testis 10.0 AFP CEACAM5
26 bile duct cystadenocarcinoma 10.0 AFP CEACAM5
27 liver sarcoma 10.0 AFP CEACAM5
28 rete testis adenocarcinoma 10.0 AFP CEACAM5
29 rete testis neoplasm 10.0 AFP CEACAM5
30 epidermolysis bullosa, junctional, herlitz type 10.0 AFP CEACAM5
31 extragonadal seminoma 10.0 AFP CEACAM5
32 mixed cell type cancer 10.0 AFP CEACAM5
33 tracheal cancer 10.0 AFP CEACAM5
34 sex cord-gonadal stromal tumor 10.0 AFP GNAS
35 colonic disease 10.0 CEACAM5 KRAS
36 testicular yolk sac tumor 10.0 AFP CEACAM5
37 hepatoid adenocarcinoma 10.0
38 papillary adenocarcinoma 10.0
39 mucosal melanoma 10.0 BRAF NF1
40 leopard syndrome 10.0 BRAF NF1
41 lymphoma 9.9
42 dermatomyositis 9.9
43 cystadenocarcinoma 9.9
44 pseudomyxoma peritonei 9.9
45 mucinous cystadenocarcinoma 9.9
46 breast mucinous carcinoma 9.9
47 adenocarcinoma in situ 9.9
48 appendicitis 9.9
49 lymphosarcoma 9.9
50 gelatinous ascites 9.9

Graphical network of the top 20 diseases related to Urachal Adenocarcinoma:



Diseases related to Urachal Adenocarcinoma

Symptoms & Phenotypes for Urachal Adenocarcinoma

GenomeRNAi Phenotypes related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.33 BRAF KRAS NF1
2 Increased cell migration GR00055-A-3 9.13 BRAF KRAS NF1
3 Reduced mammosphere formation GR00396-S 8.92 AFP BRAF GNAS KRAS

MGI Mouse Phenotypes related to Urachal Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.85 AFP BRAF GNAS KRAS NF1
2 craniofacial MP:0005382 9.78 BRAF GNAS KRAS NF1
3 liver/biliary system MP:0005370 9.77 AFP BRAF GNAS KRAS NF1
4 hearing/vestibular/ear MP:0005377 9.73 BRAF GNAS KRAS NF1
5 limbs/digits/tail MP:0005371 9.71 BRAF GNAS KRAS NF1
6 neoplasm MP:0002006 9.65 AFP BRAF GNAS KRAS NF1
7 muscle MP:0005369 9.62 BRAF GNAS KRAS NF1
8 pigmentation MP:0001186 9.33 BRAF KRAS NF1
9 renal/urinary system MP:0005367 9.26 BRAF GNAS KRAS NF1
10 respiratory system MP:0005388 8.92 BRAF GNAS KRAS NF1

Drugs & Therapeutics for Urachal Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Urachal Adenocarcinoma

Genetic Tests for Urachal Adenocarcinoma

Anatomical Context for Urachal Adenocarcinoma

MalaCards organs/tissues related to Urachal Adenocarcinoma:

42
Ovary, Colon, Breast, Prostate, Brain, Kidney, Lymph Node

Publications for Urachal Adenocarcinoma

Articles related to Urachal Adenocarcinoma:

(show top 50) (show all 97)
# Title Authors Year
1
Urachal Adenocarcinoma: A Case Report with Key Imaging Findings and Radiologic-Pathologic Correlation. ( 29682385 )
2018
2
Urachal adenocarcinoma. ( 30219781 )
2018
3
Invasive non-urachal adenocarcinoma of the bladder: analysis of the National Cancer Database. ( 30030660 )
2018
4
Response to: Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma: author reply. ( 28666644 )
2017
5
Response to: Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma. ( 28666639 )
2017
6
Urachal adenocarcinoma: a rare case report. ( 28228881 )
2017
7
Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma. ( 28285720 )
2017
8
Whole exome sequencing of urachal adenocarcinoma reveals recurrent NF1 mutations. ( 27078850 )
2016
9
Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma: A rare case report and literature review. ( 27583877 )
2016
10
Fine Needle Aspiration Cytology Diagnosis of an Urachal Adenocarcinoma. ( 27190817 )
2016
11
Rare presentation of urachal adenocarcinoma with skip metastasis to colon. ( 27555687 )
2016
12
Urachal Adenocarcinoma in a Dog. ( 27009748 )
2016
13
Extended partial cystectomy with augmentation cystoplasty in urachal adenocarcinoma: An oncologically favorable but underutilized alternative to radical cystectomy. ( 27453665 )
2016
14
Urachal adenocarcinoma incidentally discovered in a young woman at elective caesarean section. ( 27353172 )
2016
15
Urachal adenocarcinoma of the bladder, our experience in 20 years. ( 25774825 )
2015
16
En Bloc Robot-assisted Laparoscopic Partial Cystectomy, Urachal Resection, and Pelvic Lymphadenectomy for Urachal Adenocarcinoma. ( 26029004 )
2015
17
Bladder sparing robot-assisted laparoscopic en bloc resection of urachus and umbilicus for urachal adenocarcinoma. ( 26531120 )
2015
18
Robotic Partial Cystectomy for Primary Urachal Adenocarcinoma of the Urinary Bladder. ( 30263024 )
2015
19
Response to targeted therapy in urachal adenocarcinoma. ( 25568747 )
2014
20
A Comprehensive Review of Pediatric Urachal Anomalies and Predictive Analysis for Adult Urachal Adenocarcinoma Development. ( 25219697 )
2014
21
Unusual presentation of urachal adenocarcinoma with genitourinary cutaneous metastasis. ( 25337842 )
2014
22
18FDG PET/CT findings in the unusual urachal adenocarcinoma. ( 24566402 )
2014
23
High-stage urachal adenocarcinoma can be associated with microsatellite instability and KRAS mutations. ( 24355196 )
2014
24
A rare cause of urachal adenocarcinoma: urachal diverticle. ( 23476880 )
2013
25
A rare case of recurrent urachal adenocarcinoma of the bladder. ( 23914577 )
2013
26
Outcomes of Korean patients with clinically localized urachal or non-urachal adenocarcinoma of the bladder. ( 21458312 )
2013
27
The different morphologies of urachal adenocarcinoma do not discriminate genomically by micro-RNA expression profiling. ( 23528864 )
2013
28
Combined modalities treatment of pulmonary metastasis from an urachal adenocarcinoma. ( 24179644 )
2013
29
Urachal adenocarcinoma: big dimensions without involvement of the bladder wall. ( 22641501 )
2012
30
A case of metastatic urachal adenocarcinoma treated with several different chemotherapeutic regimens. ( 22396380 )
2012
31
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for patients with peritoneal carcinomatosis secondary to urachal adenocarcinoma. ( 22271499 )
2012
32
Urachal adenocarcinoma. Case report and bibliographic review. ( 22619143 )
2012
33
Urachal adenocarcinoma: a clinician's guide for treatment. ( 23040259 )
2012
34
Prostatic urethral recurrence of urachal adenocarcinoma. ( 21900110 )
2011
35
Urachal adenocarcinoma metastatic to the ovaries resembling primary ovarian mucinous carcinoma: a case report with the immunohistochemical study. ( 21228934 )
2010
36
Alpha-methylacyl-coenzyme a racemase-expressing urachal adenocarcinoma of the abdominal wall. ( 20664785 )
2010
37
Urachal adenocarcinoma with late brain metastases. ( 20945591 )
2010
38
Robotic-assisted partial cystectomy with en bloc excision of the urachus and the umbilicus for urachal adenocarcinoma. ( 27628636 )
2010
39
Urachal adenocarcinoma following kidney transplantation: the first case report. ( 19545760 )
2009
40
Enteric type urachal adenocarcinoma: a case report. ( 19671231 )
2009
41
Laparoscopic treatment of mucinous urachal adenocarcinoma with mucocele. ( 19238053 )
2009
42
Treatment of metastatic urachal adenocarcinoma in a young woman: a case report. ( 20062662 )
2009
43
Robotic assisted laparoscopic partial cystectomy and urachal resection for urachal adenocarcinoma. ( 19860941 )
2009
44
Urachal adenocarcinoma masquerading as an urachal cyst. ( 23133041 )
2008
45
Urachal adenocarcinoma. ( 18554640 )
2008
46
Preliminary report of multimodal treatment with ifosfamide, 5-fluorouracil, etoposide and cisplatin (IFEP chemotherapy) against metastatic adenocarcinoma of the urachus. ( 18786207 )
2008
47
Laparoscopic partial cystectomy with en bloc resection of the urachus for urachal adenocarcinoma. ( 17880303 )
2007
48
Laparoscopic en bloc partial cystectomy with bilateral pelvic lymphadenectomy for urachal adenocarcinoma. ( 16618570 )
2006
49
Urachal adenocarcinoma: incidental finding at the time of surgery for ruptured appendicitis. ( 17212903 )
2006
50
Ovarian metastases from an urachal adenocarcinoma. ( 16257483 )
2006

Variations for Urachal Adenocarcinoma

Expression for Urachal Adenocarcinoma

Search GEO for disease gene expression data for Urachal Adenocarcinoma.

Pathways for Urachal Adenocarcinoma

Pathways related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1 12.56 BRAF GNAS KRAS
2
Show member pathways
12.52 BRAF GNAS KRAS
3 12.48 BRAF KRAS NF1
4
Show member pathways
12.45 BRAF GNAS KRAS
5
Show member pathways
12.38 BRAF GNAS KRAS
6
Show member pathways
12.37 BRAF GNAS KRAS
7
Show member pathways
12.15 BRAF GNAS KRAS NF1
8
Show member pathways
12.1 BRAF KRAS NF1
9
Show member pathways
11.9 BRAF GNAS KRAS NF1
10
Show member pathways
11.87 BRAF GNAS KRAS
11 11.85 BRAF GNAS KRAS
12 11.8 BRAF KRAS NF1
13
Show member pathways
11.71 BRAF KRAS NF1
14 11.6 BRAF GNAS KRAS
15
Show member pathways
11.57 BRAF KRAS
16 11.55 BRAF KRAS NF1
17 11.51 BRAF KRAS
18 11.47 BRAF GNAS
19
Show member pathways
11.44 BRAF KRAS
20 11.43 BRAF GNAS KRAS
21 11.38 BRAF KRAS NF1
22 11.3 BRAF GNAS
23 11.28 BRAF NF1
24 11.27 KRAS NF1
25 11.23 AFP NF1
26 11.21 BRAF KRAS
27 11.1 BRAF GNAS KRAS
28 11.09 BRAF KRAS
29 10.96 BRAF KRAS
30 10.87 BRAF GNAS
31 10.77 BRAF GNAS
32 10.58 BRAF GNAS KRAS

GO Terms for Urachal Adenocarcinoma

Biological processes related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.5 BRAF KRAS NF1
2 liver development GO:0001889 9.43 KRAS NF1
3 Ras protein signal transduction GO:0007265 9.4 KRAS NF1
4 cognition GO:0050890 9.37 GNAS NF1
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.26 KRAS NF1
6 regulation of synaptic transmission, GABAergic GO:0032228 9.16 KRAS NF1
7 visual learning GO:0008542 9.13 BRAF KRAS NF1
8 forebrain astrocyte development GO:0021897 8.62 KRAS NF1

Sources for Urachal Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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