MCID: URC003
MIFTS: 36

Urachal Adenocarcinoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Urachal Adenocarcinoma

MalaCards integrated aliases for Urachal Adenocarcinoma:

Name: Urachal Adenocarcinoma 53 73
Adenocarcinoma of the Urachus 53

Classifications:



External Ids:

UMLS 73 C2931201

Summaries for Urachal Adenocarcinoma

MalaCards based summary : Urachal Adenocarcinoma, also known as adenocarcinoma of the urachus, is related to adenocarcinoma and colorectal adenocarcinoma. An important gene associated with Urachal Adenocarcinoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Pathways in cancer and Beta-Adrenergic Signaling. Affiliated tissues include ovary, colon and liver, and related phenotypes are Decreased cell migration and Increased cell migration

Related Diseases for Urachal Adenocarcinoma

Diseases related to Urachal Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 31.1 BRAF GNAS KRAS
2 colorectal adenocarcinoma 29.8 BRAF CEACAM5 KRAS
3 bladder urachal adenocarcinoma 12.2
4 mucinous adenocarcinoma 10.5
5 degos 'en cocarde' erythrokeratoderma 10.3
6 mucinous cystadenofibroma 10.1 AFP CEACAM5
7 liver lymphoma 10.1 AFP CEACAM5
8 melanotic medulloblastoma 10.1 AFP CEACAM5
9 signet ring cell adenocarcinoma 10.1
10 hematocele of tunica vaginalis testis 10.1 AFP CEACAM5
11 bile duct cystadenocarcinoma 10.1 AFP CEACAM5
12 liver sarcoma 10.1 AFP CEACAM5
13 rete testis adenocarcinoma 10.1 AFP CEACAM5
14 rete testis neoplasm 10.1 AFP CEACAM5
15 epidermolysis bullosa, junctional, herlitz type 10.1 AFP CEACAM5
16 hyperplastic polyposis syndrome 10.1 BRAF KRAS
17 extragonadal seminoma 10.1 AFP CEACAM5
18 syringocystadenoma papilliferum 10.1 BRAF KRAS
19 mixed cell type cancer 10.1 AFP CEACAM5
20 sigmoid neoplasm 10.1 CEACAM5 KRAS
21 tracheal cancer 10.1 AFP CEACAM5
22 apocrine adenoma 10.1 CEACAM5 KRAS
23 testicular yolk sac tumor 10.1 AFP CEACAM5
24 aggressive digital papillary adenocarcinoma 10.1 CEACAM5 KRAS
25 biliary papillomatosis 10.1 CEACAM5 KRAS
26 bile duct disease 10.0 AFP CEACAM5
27 gastrointestinal system benign neoplasm 10.0 CEACAM5 KRAS
28 biliary tract disease 10.0 AFP CEACAM5
29 ovary adenocarcinoma 10.0 CEACAM5 KRAS
30 cardiofaciocutaneous syndrome 1 10.0 BRAF KRAS
31 intestinal benign neoplasm 10.0 CEACAM5 KRAS
32 sex cord-gonadal stromal tumor 10.0 AFP GNAS
33 appendix disease 10.0 GNAS KRAS
34 ovarian cancer 1 10.0 CEACAM5 KRAS
35 malignant ovarian surface epithelial-stromal neoplasm 10.0 CEACAM5 KRAS
36 ovarian cystadenocarcinoma 10.0 GNAS KRAS
37 ovary epithelial cancer 10.0 CEACAM5 KRAS
38 leukemia, chronic lymphocytic 2 10.0 BRAF KRAS
39 colonic disease 10.0 CEACAM5 KRAS
40 testicular germ cell tumor 10.0 AFP BRAF
41 intrahepatic cholangiocarcinoma 10.0 AFP KRAS
42 gallbladder disease 10.0 CEACAM5 KRAS
43 mucosal melanoma 10.0 BRAF NF1
44 rectal neoplasm 10.0 CEACAM5 KRAS
45 leopard syndrome 10.0 BRAF NF1
46 mature teratoma 10.0 AFP BRAF KRAS
47 hepatoid adenocarcinoma 10.0
48 papillary adenocarcinoma 10.0
49 tolosa-hunt syndrome 10.0 CEACAM5 NF1
50 respiratory system cancer 9.9 CEACAM5 KRAS

Graphical network of the top 20 diseases related to Urachal Adenocarcinoma:



Diseases related to Urachal Adenocarcinoma

Symptoms & Phenotypes for Urachal Adenocarcinoma

GenomeRNAi Phenotypes related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.33 BRAF KRAS NF1
2 Increased cell migration GR00055-A-3 9.13 BRAF KRAS NF1
3 Reduced mammosphere formation GR00396-S 8.92 AFP BRAF GNAS KRAS

MGI Mouse Phenotypes related to Urachal Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.85 AFP BRAF GNAS KRAS NF1
2 craniofacial MP:0005382 9.78 BRAF GNAS KRAS NF1
3 liver/biliary system MP:0005370 9.77 AFP BRAF GNAS KRAS NF1
4 hearing/vestibular/ear MP:0005377 9.73 BRAF GNAS KRAS NF1
5 limbs/digits/tail MP:0005371 9.71 BRAF GNAS KRAS NF1
6 neoplasm MP:0002006 9.65 AFP BRAF GNAS KRAS NF1
7 muscle MP:0005369 9.62 BRAF GNAS KRAS NF1
8 pigmentation MP:0001186 9.33 BRAF KRAS NF1
9 renal/urinary system MP:0005367 9.26 BRAF GNAS KRAS NF1
10 respiratory system MP:0005388 8.92 BRAF GNAS KRAS NF1

Drugs & Therapeutics for Urachal Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Urachal Adenocarcinoma

Genetic Tests for Urachal Adenocarcinoma

Anatomical Context for Urachal Adenocarcinoma

MalaCards organs/tissues related to Urachal Adenocarcinoma:

41
Ovary, Colon, Liver, Bone, Thyroid, Testis, Cerebellum

Publications for Urachal Adenocarcinoma

Articles related to Urachal Adenocarcinoma:

(show top 50) (show all 97)
# Title Authors Year
1
Urachal Adenocarcinoma: A Case Report with Key Imaging Findings and Radiologic-Pathologic Correlation. ( 29682385 )
2018
2
Urachal adenocarcinoma. ( 30219781 )
2018
3
Invasive non-urachal adenocarcinoma of the bladder: analysis of the National Cancer Database. ( 30030660 )
2018
4
Response to: Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma: author reply. ( 28666644 )
2017
5
Response to: Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma. ( 28666639 )
2017
6
Urachal adenocarcinoma: a rare case report. ( 28228881 )
2017
7
Absence of GNAS and BRAF mutations but presence of KRAS mutation in urachal adenocarcinoma. ( 28285720 )
2017
8
Whole exome sequencing of urachal adenocarcinoma reveals recurrent NF1 mutations. ( 27078850 )
2016
9
Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma: A rare case report and literature review. ( 27583877 )
2016
10
Fine Needle Aspiration Cytology Diagnosis of an Urachal Adenocarcinoma. ( 27190817 )
2016
11
Rare presentation of urachal adenocarcinoma with skip metastasis to colon. ( 27555687 )
2016
12
Urachal Adenocarcinoma in a Dog. ( 27009748 )
2016
13
Extended partial cystectomy with augmentation cystoplasty in urachal adenocarcinoma: An oncologically favorable but underutilized alternative to radical cystectomy. ( 27453665 )
2016
14
Urachal adenocarcinoma incidentally discovered in a young woman at elective caesarean section. ( 27353172 )
2016
15
Urachal adenocarcinoma of the bladder, our experience in 20 years. ( 25774825 )
2015
16
En Bloc Robot-assisted Laparoscopic Partial Cystectomy, Urachal Resection, and Pelvic Lymphadenectomy for Urachal Adenocarcinoma. ( 26029004 )
2015
17
Bladder sparing robot-assisted laparoscopic en bloc resection of urachus and umbilicus for urachal adenocarcinoma. ( 26531120 )
2015
18
Robotic Partial Cystectomy for Primary Urachal Adenocarcinoma of the Urinary Bladder. ( 30263024 )
2015
19
Response to targeted therapy in urachal adenocarcinoma. ( 25568747 )
2014
20
A Comprehensive Review of Pediatric Urachal Anomalies and Predictive Analysis for Adult Urachal Adenocarcinoma Development. ( 25219697 )
2014
21
Unusual presentation of urachal adenocarcinoma with genitourinary cutaneous metastasis. ( 25337842 )
2014
22
18FDG PET/CT findings in the unusual urachal adenocarcinoma. ( 24566402 )
2014
23
High-stage urachal adenocarcinoma can be associated with microsatellite instability and KRAS mutations. ( 24355196 )
2014
24
A rare cause of urachal adenocarcinoma: urachal diverticle. ( 23476880 )
2013
25
A rare case of recurrent urachal adenocarcinoma of the bladder. ( 23914577 )
2013
26
Outcomes of Korean patients with clinically localized urachal or non-urachal adenocarcinoma of the bladder. ( 21458312 )
2013
27
The different morphologies of urachal adenocarcinoma do not discriminate genomically by micro-RNA expression profiling. ( 23528864 )
2013
28
Combined modalities treatment of pulmonary metastasis from an urachal adenocarcinoma. ( 24179644 )
2013
29
Urachal adenocarcinoma: big dimensions without involvement of the bladder wall. ( 22641501 )
2012
30
A case of metastatic urachal adenocarcinoma treated with several different chemotherapeutic regimens. ( 22396380 )
2012
31
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for patients with peritoneal carcinomatosis secondary to urachal adenocarcinoma. ( 22271499 )
2012
32
Urachal adenocarcinoma. Case report and bibliographic review. ( 22619143 )
2012
33
Urachal adenocarcinoma: a clinician's guide for treatment. ( 23040259 )
2012
34
Prostatic urethral recurrence of urachal adenocarcinoma. ( 21900110 )
2011
35
Urachal adenocarcinoma metastatic to the ovaries resembling primary ovarian mucinous carcinoma: a case report with the immunohistochemical study. ( 21228934 )
2010
36
Alpha-methylacyl-coenzyme a racemase-expressing urachal adenocarcinoma of the abdominal wall. ( 20664785 )
2010
37
Urachal adenocarcinoma with late brain metastases. ( 20945591 )
2010
38
Robotic-assisted partial cystectomy with en bloc excision of the urachus and the umbilicus for urachal adenocarcinoma. ( 27628636 )
2010
39
Urachal adenocarcinoma following kidney transplantation: the first case report. ( 19545760 )
2009
40
Enteric type urachal adenocarcinoma: a case report. ( 19671231 )
2009
41
Laparoscopic treatment of mucinous urachal adenocarcinoma with mucocele. ( 19238053 )
2009
42
Treatment of metastatic urachal adenocarcinoma in a young woman: a case report. ( 20062662 )
2009
43
Robotic assisted laparoscopic partial cystectomy and urachal resection for urachal adenocarcinoma. ( 19860941 )
2009
44
Urachal adenocarcinoma masquerading as an urachal cyst. ( 23133041 )
2008
45
Urachal adenocarcinoma. ( 18554640 )
2008
46
Preliminary report of multimodal treatment with ifosfamide, 5-fluorouracil, etoposide and cisplatin (IFEP chemotherapy) against metastatic adenocarcinoma of the urachus. ( 18786207 )
2008
47
Laparoscopic partial cystectomy with en bloc resection of the urachus for urachal adenocarcinoma. ( 17880303 )
2007
48
Laparoscopic en bloc partial cystectomy with bilateral pelvic lymphadenectomy for urachal adenocarcinoma. ( 16618570 )
2006
49
Urachal adenocarcinoma: incidental finding at the time of surgery for ruptured appendicitis. ( 17212903 )
2006
50
Ovarian metastases from an urachal adenocarcinoma. ( 16257483 )
2006

Variations for Urachal Adenocarcinoma

Expression for Urachal Adenocarcinoma

Search GEO for disease gene expression data for Urachal Adenocarcinoma.

Pathways for Urachal Adenocarcinoma

Pathways related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1 12.56 BRAF GNAS KRAS
2
Show member pathways
12.53 BRAF GNAS KRAS
3 12.49 BRAF KRAS NF1
4
Show member pathways
12.44 BRAF GNAS KRAS
5
Show member pathways
12.39 BRAF GNAS KRAS
6
Show member pathways
12.38 BRAF GNAS KRAS
7
Show member pathways
12.23 BRAF GNAS KRAS NF1
8
Show member pathways
12.14 BRAF GNAS KRAS
9
Show member pathways
12.11 BRAF KRAS NF1
10
Show member pathways
11.99 BRAF KRAS NF1
11
Show member pathways
11.9 BRAF GNAS KRAS NF1
12
Show member pathways
11.87 BRAF GNAS KRAS
13 11.85 BRAF GNAS KRAS
14 11.8 BRAF KRAS NF1
15
Show member pathways
11.71 BRAF KRAS NF1
16 11.6 BRAF GNAS KRAS
17
Show member pathways
11.58 BRAF KRAS
18 11.55 BRAF KRAS NF1
19 11.51 BRAF KRAS
20 11.47 BRAF GNAS
21
Show member pathways
11.45 BRAF KRAS
22 11.45 BRAF GNAS KRAS
23 11.38 BRAF KRAS NF1
24 11.31 BRAF GNAS
25 11.29 BRAF NF1
26 11.29 KRAS NF1
27 11.24 AFP NF1
28 11.21 BRAF KRAS
29 11.12 BRAF GNAS KRAS
30 11.11 BRAF KRAS
31 10.97 BRAF KRAS
32 10.89 BRAF GNAS
33 10.77 BRAF GNAS
34 10.58 BRAF GNAS KRAS

GO Terms for Urachal Adenocarcinoma

Biological processes related to Urachal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.5 BRAF KRAS NF1
2 liver development GO:0001889 9.43 KRAS NF1
3 Ras protein signal transduction GO:0007265 9.4 KRAS NF1
4 cognition GO:0050890 9.37 GNAS NF1
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.26 KRAS NF1
6 regulation of synaptic transmission, GABAergic GO:0032228 9.16 KRAS NF1
7 visual learning GO:0008542 9.13 BRAF KRAS NF1
8 forebrain astrocyte development GO:0021897 8.62 KRAS NF1

Sources for Urachal Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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