MCID: URC004
MIFTS: 18

Urachal Cancer

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Urachal Cancer

MalaCards integrated aliases for Urachal Cancer:

Name: Urachal Cancer 53 73
Urachal Carcinoma 53

Classifications:



External Ids:

UMLS 73 C2931202

Summaries for Urachal Cancer

NIH Rare Diseases : 53 Urachal cancer is a type of bladder cancer, making up less than 1% of all bladder cancers. The urachus is a structure normally only present during development in the womb that connects the bellybutton and the bladder. This connection normally disappears before birth, but in some people remains. Urachal cancers are usually diagnosed in adults in their 50's and 60's and may develop at the dome or anterior wall of the bladder, along the midline of the body (including the belly button), and between the pubis symphasis and the bladder. Most urachal cancers are adenocarcinomas (cancers that develop from gland cells). Others may be sarcomas (which develop from connective tissue - such as leiomyosarcoma, rhabdomyosarcoma, and malignant fibrous histiocytoma), small cell carcinomas, transitional cell cancer, and mixed neoplasias. Most individuals with urachal cancer have symptoms of with hematuria (blood in urine). Other symptoms may include abdominal pain, a palpable abdominal mass, mucinuria, and bacteriuria. Treatment usually involved surgery to remove the cancer.

MalaCards based summary : Urachal Cancer, also known as urachal carcinoma, is related to bladder urachal carcinoma and adenocarcinoma. An important gene associated with Urachal Cancer is CEACAM5 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 5). The drugs Gemcitabine and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include colon.

Wikipedia : 76 Urachal cancer is a very rare type of cancer arising from the urachus or its remnants. The disease might... more...

Related Diseases for Urachal Cancer

Diseases related to Urachal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 bladder urachal carcinoma 12.0
2 adenocarcinoma 9.7
3 fasciitis 9.7
4 urachal diverticulum 9.7

Symptoms & Phenotypes for Urachal Cancer

Drugs & Therapeutics for Urachal Cancer

Drugs for Urachal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 2 95058-81-4 60750
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
Fluorouracil Approved Phase 2 51-21-8 3385
4
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
5
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
6 Immunosuppressive Agents Phase 2
7 Anti-Infective Agents Phase 2
8 Antimetabolites Phase 2
9 Antiviral Agents Phase 2
10 Antimetabolites, Antineoplastic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fluorouracil, Leucovorin, Gemcitabine, and Cisplatin in Treating Patients With Metastatic or Unresectable Adenocarcinoma of the Urothelium or Urachal Remnant Active, not recruiting NCT00082706 Phase 2 5-Fluorouracil (5-FU);Leucovorin;Cisplatin;Gemcitabine

Search NIH Clinical Center for Urachal Cancer

Genetic Tests for Urachal Cancer

Anatomical Context for Urachal Cancer

MalaCards organs/tissues related to Urachal Cancer:

41
Colon

Publications for Urachal Cancer

Articles related to Urachal Cancer:

(show all 19)
# Title Authors Year
1
Biomarkers in Urachal Cancer and Adenocarcinomas in the Bladder: A Comprehensive Review Supplemented by Own Data. ( 29721106 )
2018
2
Telomerase reverse transcriptase (TERT) promoter mutations are rare in urachal cancer. ( 29047227 )
2017
3
Incidentally discovered urachal cancer in a patient with necrotising fasciitis of the abdominal wall. ( 27118740 )
2016
4
Genetics and biological markers in urachal cancer. ( 27785422 )
2016
5
A Case of Metastatic Urachal Cancer Including a Neuroendocrine Component Treated with Gemcitabine, Cisplatin and Paclitaxel Combination Chemotherapy. ( 27339213 )
2016
6
Clinical outcome of urachal cancer in Japanese patients. ( 26138265 )
2015
7
Urachal Cancer: contemporary review of the pathological, surgical, and prognostic aspects of this rare disease. ( 26583595 )
2015
8
A Case of Urachal Malacoplakia that Seems Like Urachal Cancer. ( 25759783 )
2015
9
Urachal cancer with direct caecal invasion: differential diagnosis from primary colon cancer. ( 24903722 )
2014
10
Prognostic factors for urachal cancer: a bayesian model-averaging approach. ( 25237458 )
2014
11
Treatment outcome and relevance of palliative chemotherapy in urachal cancer. ( 25471123 )
2014
12
Modified FOLFOX6 chemotherapy in patients with metastatic urachal cancer. ( 24969043 )
2013
13
Response of recurrent urachal cancer to gemcitabine and cisplatin therapy: a case report and literature review. ( 21737660 )
2011
14
Metastatic urachal cancer responding to FOLFOX chemotherapy. ( 20398453 )
2010
15
Predictors of survival from urachal cancer: a Mayo Clinic study of 49 cases. ( 17932892 )
2007
16
Irinotecan as a new agent for urachal cancer. ( 16601395 )
2006
17
Urachal cancer: role of conservative surgery. ( 8256396 )
1993
18
Urachal cancer. ( 3842640 )
1985
19
Computed tomography and ultrasound of a urachal cancer. ( 2998529 )
1985

Variations for Urachal Cancer

Cosmic variations for Urachal Cancer:

9
(show all 32)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6191549 WT1 urinary tract,urachus,carcinoma,adenocarcinoma c.1282T>C p.S428P 11:32389126-32389126 5
2 COSM2114555 WT1 urinary tract,urachus,carcinoma,adenocarcinoma c.847G>A p.G283R 11:32399995-32399995 5
3 COSM10659 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.817C>T p.R273C 17:7673803-7673803 5
4 COSM10834 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.711G>A p.M237I 17:7674252-7674252 5
5 COSM10870 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.523C>G p.R175G 17:7675089-7675089 5
6 COSM10656 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 5
7 COSM10663 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 5
8 COSM11496 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.476C>A p.A159D 17:7675136-7675136 5
9 COSM10648 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.524G>A p.R175H 17:7675088-7675088 5
10 COSM14122 SMAD4 urinary tract,urachus,carcinoma,adenocarcinoma c.1082G>A p.R361H 18:51065549-51065549 5
11 COSM14169 SMAD4 urinary tract,urachus,carcinoma,adenocarcinoma c.988G>A p.E330K 18:51065455-51065455 5
12 COSM373800 SMAD4 urinary tract,urachus,carcinoma,adenocarcinoma c.1052A>G p.D351G 18:51065519-51065519 5
13 COSM585 NRAS urinary tract,urachus,carcinoma,adenocarcinoma c.183A>T p.Q61H 1:114713907-114713907 5
14 COSM6930558 NOTCH1 urinary tract,urachus,carcinoma,adenocarcinoma c.298A>T p.T100S 9:136523822-136523822 5
15 COSM6191423 LRP1B urinary tract,urachus,carcinoma,adenocarcinoma c.6256A>G p.M2086V 2:140702187-140702187 5
16 COSM532 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 5
17 COSM19404 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.436G>A p.A146T 12:25225628-25225628 5
18 COSM19900 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.437C>T p.A146V 12:25225627-25225627 5
19 COSM521 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 5
20 COSM520 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 5
21 COSM518 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.34G>C p.G12R 12:25245351-25245351 5
22 COSM517 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.34G>A p.G12S 12:25245351-25245351 5
23 COSM553 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.182A>T p.Q61L 12:25227342-25227342 5
24 COSM6191368 CBL urinary tract,urachus,carcinoma,adenocarcinoma c.2520T>G p.C840W 11:119299580-119299580 5
25 COSM476 BRAF urinary tract,urachus,carcinoma,adenocarcinoma c.1799T>A p.V600E 7:140753336-140753336 5
26 COSM6168530 APC urinary tract,urachus,carcinoma,adenocarcinoma c.1252G>A p.E418K 5:112819284-112819284 5
27 COSM6191422 APC urinary tract,urachus,carcinoma,adenocarcinoma c.3331G>T p.E1111* 5:112838925-112838925 5
28 COSM6191379 APC urinary tract,urachus,carcinoma,adenocarcinoma c.1249T>A p.C417S 5:112819281-112819281 5
29 COSM6191378 APC urinary tract,urachus,carcinoma,adenocarcinoma c.1061C>G p.P354R 5:112819093-112819093 5
30 COSM1165198 urinary tract,urachus,carcinoma,adenocarcinoma c.436G>A p.A146T 12:25225628-25225628 5
31 COSM6930557 urinary tract,urachus,carcinoma,adenocarcinoma c.298A>T p.T100S 9:136523822-136523822 5
32 COSM13016 PTPN11 soft tissue,bladder,rhabdomyosarcoma,embryonal c.226G>C p.E76Q 12:112450406-112450406 3

Expression for Urachal Cancer

Search GEO for disease gene expression data for Urachal Cancer.

Pathways for Urachal Cancer

GO Terms for Urachal Cancer

Sources for Urachal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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