MCID: URC004
MIFTS: 25

Urachal Cancer

Categories: Cancer diseases, Endocrine diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Urachal Cancer

MalaCards integrated aliases for Urachal Cancer:

Name: Urachal Cancer 53 73
Urachal Carcinoma 53

Classifications:



External Ids:

UMLS 73 C2931202

Summaries for Urachal Cancer

NIH Rare Diseases : 53 Urachal cancer is a type of bladder cancer, making up less than 1% of all bladder cancers. The urachus is a structure normally only present during development in the womb that connects the bellybutton and the bladder. This connection normally disappears before birth, but in some people remains. Urachal cancers are usually diagnosed in adults in their 50's and 60's and may develop at the dome or anterior wall of the bladder, along the midline of the body (including the belly button), and between the pubis symphasis and the bladder. Most urachal cancers are adenocarcinomas (cancers that develop from gland cells). Others may be sarcomas (which develop from connective tissue - such as leiomyosarcoma, rhabdomyosarcoma, and malignant fibrous histiocytoma), small cell carcinomas, transitional cell cancer, and mixed neoplasias. Most individuals with urachal cancer have symptoms of with hematuria (blood in urine). Other symptoms may include abdominal pain, a palpable abdominal mass, mucinuria, and bacteriuria. Treatment usually involved surgery to remove the cancer.

MalaCards based summary : Urachal Cancer, also known as urachal carcinoma, is related to bladder urachal carcinoma and mixed ductal-endocrine carcinoma. An important gene associated with Urachal Cancer is TERT (Telomerase Reverse Transcriptase). The drugs leucovorin and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include bone, colon and lung.

Wikipedia : 76 Urachal cancer is a very rare type of cancer arising from the urachus or its remnants. The disease might... more...

Related Diseases for Urachal Cancer

Graphical network of the top 20 diseases related to Urachal Cancer:



Diseases related to Urachal Cancer

Symptoms & Phenotypes for Urachal Cancer

Drugs & Therapeutics for Urachal Cancer

Drugs for Urachal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 2 58-05-9 6006 143
2
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
3
Fluorouracil Approved Phase 2 51-21-8 3385
4
Gemcitabine Approved Phase 2 95058-81-4 60750
5
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
6 Anti-Infective Agents Phase 2
7 Antimetabolites, Antineoplastic Phase 2
8 Immunologic Factors Phase 2
9 Antiviral Agents Phase 2
10 Antimetabolites Phase 2
11 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fluorouracil, Leucovorin, Gemcitabine, and Cisplatin in Treating Patients With Metastatic or Unresectable Adenocarcinoma of the Urothelium or Urachal Remnant Active, not recruiting NCT00082706 Phase 2 5-Fluorouracil (5-FU);Leucovorin;Cisplatin;Gemcitabine

Search NIH Clinical Center for Urachal Cancer

Genetic Tests for Urachal Cancer

Anatomical Context for Urachal Cancer

MalaCards organs/tissues related to Urachal Cancer:

41
Bone, Colon, Lung, Thyroid, Brain, Kidney, Lymph Node

Publications for Urachal Cancer

Articles related to Urachal Cancer:

(show top 50) (show all 109)
# Title Authors Year
1
Biomarkers in Urachal Cancer and Adenocarcinomas in the Bladder: A Comprehensive Review Supplemented by Own Data. ( 29721106 )
2018
2
A Large Urinary Bladder Hemangioma Mimicking Urachal Cancer: A Case Report and Literature Review. ( 30308263 )
2018
3
Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence. ( 30009079 )
2018
4
A rare inflammatory myofibroblastic bladder tumor masquerading urachal carcinoma. ( 30089997 )
2018
5
Urachal carcinoma: from gross specimen to morphologic, immunohistochemical, and molecular analysis. ( 30302546 )
2018
6
Telomerase reverse transcriptase (TERT) promoter mutations are rare in urachal cancer. ( 29047227 )
2017
7
Urachal carcinoma: Report of two cases and review of the literature. ( 28123739 )
2017
8
Comprehensive somatic genome alterations of urachal carcinoma. ( 28348108 )
2017
9
A Rare Case of Urachal Carcinoma Metastatic to Thoracic Vertebra Detected by FDG PET/CT. ( 28481799 )
2017
10
A Case of Urachal Carcinoma of the Abdominal Wall in a Kidney Transplant Recipient. ( 28546813 )
2017
11
Mucinous Signet-Ring Urachal Carcinoma of the Bladder: Case Report and Review of the Literature. ( 28571826 )
2017
12
Pulmonary Recurrence of Urachal Carcinoma. ( 28657266 )
2017
13
Incidentally discovered urachal cancer in a patient with necrotising fasciitis of the abdominal wall. ( 27118740 )
2016
14
Genetics and biological markers in urachal cancer. ( 27785422 )
2016
15
A Case of Metastatic Urachal Cancer Including a Neuroendocrine Component Treated with Gemcitabine, Cisplatin and Paclitaxel Combination Chemotherapy. ( 27339213 )
2016
16
Combined Extraperitoneal and Transperitoneal Laparoscopic Extended Partial Cystectomy for the Treatment of Urachal Carcinoma. ( 26531333 )
2016
17
Urachal Carcinoma of the Bladder: Impact of Clinical and Immunohistochemical Parameters on Prognosis. ( 26678957 )
2016
18
Targeted Therapy Based on Tumor Genomic Analyses in Metastatic Urachal Carcinoma. ( 27102403 )
2016
19
Urachal Carcinoma with Choroidal, Lung, Lymph Node, Adrenal, Mammary, and Bone Metastases and Peritoneal Carcinomatosis Showing Partial Response after Chemotherapy Treatment with a Modified Docetaxel, Cisplatin and 5-Fluorouracil Regimen. ( 27194981 )
2016
20
Clinical, prognostic, and therapeutic aspects of urachal carcinoma-A comprehensive review with meta-analysis of 1,010 cases. ( 27267737 )
2016
21
Mutations of KRAS, NRAS, BRAF, EGFR, and PIK3CA genes in urachal carcinoma: Occurence and prognostic significance. ( 27283768 )
2016
22
Clinical Sequencing-guided Therapy of Urachal Carcinoma: New Perspective for a Rare Cancer. ( 27423504 )
2016
23
National Incidence, Management and Survival of Urachal Carcinoma. ( 27746878 )
2016
24
Surgical treatment of recurrent urachal carcinoma with liver metastasis: a case report and literature review. ( 27894318 )
2016
25
Clinical outcome of urachal cancer in Japanese patients. ( 26138265 )
2015
26
Urachal Cancer: contemporary review of the pathological, surgical, and prognostic aspects of this rare disease. ( 26583595 )
2015
27
A Case of Urachal Malacoplakia that Seems Like Urachal Cancer. ( 25759783 )
2015
28
The Youngest Korean Case of Urachal Carcinoma. ( 26146584 )
2015
29
Urachal carcinoma: a pathologic and clinical study of 46 cases. ( 26364859 )
2015
30
A Case of Metastatic Urachal Carcinoma Treated With FOLFIRI (irinotecan and 5-Fluorouracil/leucovorin) Plus Bevacizumab. ( 26793485 )
2015
31
Urachal cancer with direct caecal invasion: differential diagnosis from primary colon cancer. ( 24903722 )
2014
32
Prognostic factors for urachal cancer: a bayesian model-averaging approach. ( 25237458 )
2014
33
Treatment Outcome and Relevance of Palliative Chemotherapy in Urachal Cancer. ( 25471123 )
2014
34
Organized urachal abscess mimicking urachal carcinoma on FDG PET/CT. ( 24217540 )
2014
35
Investigating urachal carcinoma for more than 15 years. ( 25295114 )
2014
36
Urachal carcinoma: clinicopathological features, treatment and outcome. ( 25313741 )
2014
37
Rare use of robotic surgery for removal of large urachal carcinoma. ( 27637529 )
2014
38
Modified FOLFOX6 chemotherapy in patients with metastatic urachal cancer. ( 24969043 )
2013
39
Options for diagnosis and treatment of urachal carcinoma. ( 23046343 )
2013
40
Urachal carcinoma. ( 23563388 )
2013
41
Metastatic urachal carcinoma in bronchial brush cytology. ( 23599720 )
2013
42
A rare case of metastatic squamous urachal carcinoma. ( 23618584 )
2013
43
Commentary on "The clinical epidemiology of urachal carcinoma: results of a large, population based study." Bruins HM, Visser O, Ploeg M, Hulsbergen-van de Kaa CA, Kiemeney LA, Witjes JA, Department of Urology, Radboud University Medical Centre, Utrecht, The Netherlands: J Urol 2012;188(4):1102-7 [Epub 2012 Aug 15]. ( 23796205 )
2013
44
Surgical and chemotherapeutic experience regarding a urachal carcinoma with repeated relapse: case report and literature review. ( 23914849 )
2013
45
Surgical and chemotherapeutic options for urachal carcinoma: report of ten cases and literature review. ( 22143067 )
2012
46
Brain metastasis from urachal carcinoma: the importance of locally aggressive treatment. ( 22532915 )
2012
47
The clinical epidemiology of urachal carcinoma: results of a large, population based study. ( 22901574 )
2012
48
Urachal carcinoma: imaging findings. ( 23986824 )
2012
49
Response of recurrent urachal cancer to gemcitabine and cisplatin therapy: a case report and literature review. ( 21737660 )
2011
50
Polypoid endometriosis of the bladder during pregnancy mimicking urachal carcinoma. ( 21374752 )
2011

Variations for Urachal Cancer

Cosmic variations for Urachal Cancer:

9 (show all 34)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6191549 WT1 urinary tract,urachus,carcinoma,adenocarcinoma c.1282T>C p.S428P 11:32389126-32389126 5
2 COSM2114555 WT1 urinary tract,urachus,carcinoma,adenocarcinoma c.847G>A p.G283R 11:32399995-32399995 5
3 COSM10659 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.817C>T p.R273C 17:7673803-7673803 5
4 COSM10870 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.523C>G p.R175G 17:7675089-7675089 5
5 COSM10656 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 5
6 COSM10663 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 5
7 COSM11496 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.476C>A p.A159D 17:7675136-7675136 5
8 COSM10648 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.524G>A p.R175H 17:7675088-7675088 5
9 COSM10834 TP53 urinary tract,urachus,carcinoma,adenocarcinoma c.711G>A p.M237I 17:7674252-7674252 5
10 COSM14122 SMAD4 urinary tract,urachus,carcinoma,adenocarcinoma c.1082G>A p.R361H 18:51065549-51065549 5
11 COSM14169 SMAD4 urinary tract,urachus,carcinoma,adenocarcinoma c.988G>A p.E330K 18:51065455-51065455 5
12 COSM373800 SMAD4 urinary tract,urachus,carcinoma,adenocarcinoma c.1052A>G p.D351G 18:51065519-51065519 5
13 COSM585 NRAS urinary tract,urachus,carcinoma,adenocarcinoma c.183A>T p.Q61H 1:114713907-114713907 5
14 COSM6930558 NOTCH1 urinary tract,urachus,carcinoma,adenocarcinoma c.298A>T p.T100S 9:136523822-136523822 5
15 COSM6191423 LRP1B urinary tract,urachus,carcinoma,adenocarcinoma c.6256A>G p.M2086V 2:140702187-140702187 5
16 COSM532 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 5
17 COSM19404 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.436G>A p.A146T 12:25225628-25225628 5
18 COSM19900 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.437C>T p.A146V 12:25225627-25225627 5
19 COSM521 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 5
20 COSM520 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 5
21 COSM518 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.34G>C p.G12R 12:25245351-25245351 5
22 COSM517 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.34G>A p.G12S 12:25245351-25245351 5
23 COSM553 KRAS urinary tract,urachus,carcinoma,adenocarcinoma c.182A>T p.Q61L 12:25227342-25227342 5
24 COSM1586686 CHD4 urinary tract,urachus,carcinoma,adenocarcinoma c.1040G>A p.R347Q 12:6600557-6600557 5
25 COSM2098512 CHD4 urinary tract,urachus,carcinoma,adenocarcinoma c.2870G>A p.R957Q 12:6592471-6592471 5
26 COSM6191368 CBL urinary tract,urachus,carcinoma,adenocarcinoma c.2520T>G p.C840W 11:119299580-119299580 5
27 COSM476 BRAF urinary tract,urachus,carcinoma,adenocarcinoma c.1799T>A p.V600E 7:140753336-140753336 5
28 COSM6168530 APC urinary tract,urachus,carcinoma,adenocarcinoma c.1252G>A p.E418K 5:112819284-112819284 5
29 COSM6191422 APC urinary tract,urachus,carcinoma,adenocarcinoma c.3331G>T p.E1111* 5:112838925-112838925 5
30 COSM6191379 APC urinary tract,urachus,carcinoma,adenocarcinoma c.1249T>A p.C417S 5:112819281-112819281 5
31 COSM6191378 APC urinary tract,urachus,carcinoma,adenocarcinoma c.1061C>G p.P354R 5:112819093-112819093 5
32 COSM1165198 urinary tract,urachus,carcinoma,adenocarcinoma c.436G>A p.A146T 12:25225628-25225628 5
33 COSM6930557 urinary tract,urachus,carcinoma,adenocarcinoma c.298A>T p.T100S 9:136523822-136523822 5
34 COSM13016 PTPN11 soft tissue,bladder,rhabdomyosarcoma,embryonal c.226G>C p.E76Q 12:112450406-112450406 3

Expression for Urachal Cancer

Search GEO for disease gene expression data for Urachal Cancer.

Pathways for Urachal Cancer

GO Terms for Urachal Cancer

Biological processes related to Urachal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 8.62 CEACAM5 TERT

Molecular functions related to Urachal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.96 CEACAM5 TERT
2 protein homodimerization activity GO:0042803 8.62 CEACAM5 TERT

Sources for Urachal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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