UOX
MCID: URT049
MIFTS: 24

Urate Oxidase, Pseudogene (UOX)

Aliases & Classifications for Urate Oxidase, Pseudogene

MalaCards integrated aliases for Urate Oxidase, Pseudogene:

Name: Urate Oxidase, Pseudogene 58 13
Uricase 58
Uox 58

External Ids:

OMIM 58 191540

Summaries for Urate Oxidase, Pseudogene

OMIM : 58 In most mammals, the activity of urate oxidase (EC 1.7.3.3) catalyzes the oxidation of uric acid to allantoin; humans and some primates lack this enzyme activity. The loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia, a metabolic disturbance that can lead to gouty arthritis and renal stones (summary by Wu et al., 1994). (191540)

MalaCards based summary : Urate Oxidase, Pseudogene, also known as uricase, is related to gout and hyperuricemia. An important gene associated with Urate Oxidase, Pseudogene is UOX (Urate Oxidase (Pseudogene)). The drugs Rasburicase and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney and testes.

Related Diseases for Urate Oxidase, Pseudogene

Diseases related to Urate Oxidase, Pseudogene via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 gout 10.5
2 hyperuricemia 10.5
3 lymphoma, hodgkin, classic 10.1
4 lymphoma, non-hodgkin, familial 10.1
5 lymphoma 10.1
6 diabetes insipidus 10.1
7 nephrolithiasis, calcium oxalate 10.0
8 nephrolithiasis 10.0
9 spinal muscular atrophy 10.0
10 proximal spinal muscular atrophy 10.0

Graphical network of the top 20 diseases related to Urate Oxidase, Pseudogene:



Diseases related to Urate Oxidase, Pseudogene

Symptoms & Phenotypes for Urate Oxidase, Pseudogene

Clinical features from OMIM:

191540

Drugs & Therapeutics for Urate Oxidase, Pseudogene

Drugs for Urate Oxidase, Pseudogene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rasburicase Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 134774-45-1
2 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
3
Allopurinol Approved Phase 2 315-30-0 2094
4
Uric Acid Experimental, Investigational Phase 2,Phase 1,Not Applicable 69-93-2 1175
5 Protective Agents Phase 1,Not Applicable
6 Antioxidants Phase 1,Not Applicable
7
Febuxostat Approved Not Applicable 144060-53-7 134018
8 Insulin, Globin Zinc Not Applicable
9 insulin Not Applicable
10 Hypoglycemic Agents Not Applicable
11 Flax Not Applicable
12 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of PEG-uricase in the Treatment of Hyperuricemic Patients With Symptomatic Gout Completed NCT00325195 Phase 3
2 Open-Label Extension Study for Patients Who Completed a Phase 3 Double-blind Study of PEG-uricase for Symptomatic Gout Completed NCT01356498 Phase 3
3 Pegylated Recombinant Mammalian Uricase (PEG-uricase) as Treatment for Refractory Gout Completed NCT00111657 Phase 2
4 Uric Acid Lowering Trial in Youth Onset T2D Not yet recruiting NCT03899883 Phase 2 Pegloticase 8 MG/ML [Krystexxa]
5 Safety and Efficacy Study of Intramuscular Uricase-PEG 20 Unknown status NCT01038947 Phase 1
6 Safety and Efficacy Study of Intravenous Uricase-PEG 20 Unknown status NCT01021241 Phase 1
7 Safety and Pharmacodynamics of SEL-037 (Pegsiticase) in Subjects With Elevated Blood Uric Acid Levels Completed NCT02464605 Phase 1
8 Safety and Pharmacodynamics of SEL-212 (Pegsiticase + SEL-110) in Subjects With Elevated Blood Uric Acid Levels Completed NCT02648269 Phase 1 SEL-110
9 A Study to Assess the Safety and Tolerability of SSS11 in Healthy Subjects. Recruiting NCT03388515 Phase 1
10 Study of Association Between Maternal Uric Acid , Maternal and Fetal Outcome in Pregnant Women With Hypertension Unknown status NCT01523327
11 Study of the Reliability of a Device (HumanSens Plus) Allowing Immediate Measurement Uric Acid in the Blood Obtained by Finger Tip Puncture. Unknown status NCT02671656
12 Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status Completed NCT01931527 Not Applicable Rasburicase
13 Impact of Flaxseed on the Syndrome Metabolic Inflammation Completed NCT02132728 Not Applicable
14 Uric Acid Effects on Endothelium and Oxydative Stress Recruiting NCT03395977 Not Applicable Placebos;Febuxostat;Rasburicase

Search NIH Clinical Center for Urate Oxidase, Pseudogene

Genetic Tests for Urate Oxidase, Pseudogene

Anatomical Context for Urate Oxidase, Pseudogene

MalaCards organs/tissues related to Urate Oxidase, Pseudogene:

42
Kidney, Testes

Publications for Urate Oxidase, Pseudogene

Articles related to Urate Oxidase, Pseudogene:

(show top 50) (show all 289)
# Title Authors Year
1
Uricase and Horseradish Peroxidase Hybrid CaHPO₄ Nanoflower Integrated with Transcutaneous Patches for Treatment of Hyperuricemia. ( 30890227 )
2019
2
Uricase grafted nanoconducting matrix based electrochemical biosensor for ultrafast uric acid detection in human serum samples. ( 30797811 )
2019
3
Production and Characterization of Recombinant Wild Type Uricase from Indonesian Coelacanth (L. menadoensis) and Improvement of Its Thermostability by In Silico Rational Design and Disulphide Bridges Engineering. ( 30871218 )
2019
4
A Case Report of Immunosuppressant Medication‒Associated Polyarticular Tophaceous Gout Successfully Treated Using the Polyethylene Glycol‒Conjugated Uricase Enzyme Pegloticase. ( 30577324 )
2018
5
Dextrin-uricase conjugate: Preparation, characterization, and enzymatic properties. ( 29292142 )
2018
6
Uricase-free on-demand colorimetric biosensing of uric acid enabled by integrated CoP nanosheet arrays as a monolithic peroxidase mimic. ( 29681277 )
2018
7
Ultrasound assisted process intensification of uricase and alkaline protease enzyme co-production in Bacillus licheniformis. ( 29705310 )
2018
8
Efficient purification of a recombinant tag-free thermostable Kluyveromyces marxianus uricase by pH-induced self-cleavage of intein and expression in Escherichia coli. ( 30221113 )
2018
9
Antioxidant properties of citric acid interfere with the uricase-based measurement of circulating uric acid. ( 30447534 )
2018
10
An electrochemical biosensor based on novel butylamine capped CZTS nanoparticles immobilized by uricase for uric acid detection. ( 30597431 )
2018
11
Optimization of novel and greener approach for the coproduction of uricase and alkaline protease in Bacillus licheniformis by Box-Behnken model. ( 28976246 )
2018
12
Erratum: Uricase alkaline enzymosomes with enhanced stabilities and anti-hyperuricemia effects induced by favorable microenvironmental changes. ( 28664903 )
2017
13
Uricase based fluorometric determination of uric acid based on the use of graphene quantum dot@silver core-shell nanocomposites. ( 29594655 )
2017
14
Effect of surfactants and inducers on increased uricase production under submerged fermentations by Bacillus cereus. ( 27071031 )
2017
15
A Practical System for High-Throughput Screening of Mutants of Bacillus fastidiosus Uricase. ( 27614625 )
2017
16
Impact of Mutations on the Higher Order Structure and Activity of a Recombinant Uricase. ( 28063825 )
2017
17
Oral uricase eliminates blood uric acid in the hyperuricemic pig model. ( 28594873 )
2017
18
Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid. ( 28890842 )
2017
19
Designing a mutant Candida uricase with improved polymerization state and enzymatic activity. ( 29161434 )
2017
20
Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout. ( 27352852 )
2016
21
Uricase alkaline enzymosomes with enhanced stabilities and anti-hyperuricemia effects induced by favorable microenvironmental changes. ( 26823332 )
2016
22
DNA shuffling of uricase gene leads to a more "human like" chimeric uricase with increased uricolytic activity. ( 26526169 )
2016
23
Economic analysis of uricase production under uncertainty: Contrast of chromatographic purification and aqueous two-phase extraction (with and without PEG recycle). ( 26561271 )
2016
24
Development of Therapeutic Chimeric Uricase by Exon Replacement/Restoration and Site-Directed Mutagenesis. ( 27213357 )
2016
25
Electrochemical detection of uric acid via uricase-immobilized graphene oxide. ( 27402177 )
2016
26
Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism. ( 27465529 )
2016
27
A Numerical Approach for Kinetic Analysis of the Nonexponential Thermoinactivation Process of Uricase. ( 27480193 )
2016
28
Utilizing intein-mediated protein cleaving for purification of uricase, a multimeric enzyme. ( 27702489 )
2016
29
Urinary excretion of uric acid, allantoin, and 8-OH-Deoxyguanosine in uricase-knockout mice. ( 27906613 )
2016
30
A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties. ( 28002433 )
2016
31
A novel third generation uric acid biosensor using uricase electro-activated with ferrocene on a Nafion coated glassy carbon electrode. ( 25461755 )
2015
32
Cloning, Expression, and Purification of Recombinant Uricase Enzyme from Pseudomonas aeruginosa Ps43 Using Escherichia coli. ( 25588559 )
2015
33
Enhancement of a novel extracellular uricase production by media optimization and partial purification by aqueous three-phase system. ( 25674929 )
2015
34
Purification, characterization and in vitro application of a thermostable oxidant- and SDS-stable uricase from a newly isolated Bacillus firmus DWD-33. ( 25742044 )
2015
35
Crystal structure of Bacillus fastidious uricase reveals an unexpected folding of the C-terminus residues crucial for thermostability under physiological conditions. ( 25786739 )
2015
36
Characterization of a Thermostable Uricase Isolated from Bacillus firmus DWD-33 and its Application for Uric Acid Quantification in Human Serum. ( 25981580 )
2015
37
Purification and characterization of an extracellular uricase from a new isolate of Sphingobacterium thalpophilum (VITPCB5). ( 26145833 )
2015
38
Infusion-related reactions with pegloticase, a recombinant uricase for the treatment of chronic gout refractory to conventional therapy. ( 25417679 )
2014
39
Isolation, screening and production studies of uricase producing bacteria from poultry sources. ( 24279683 )
2014
40
Comparison of modification of a bacterial uricase with N-hydroxysuccinimide esters of succinate and carbonate of monomethoxyl poly(ethylene glycol). ( 24512141 )
2014
41
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD. ( 24643131 )
2014
42
Covalent immobilization of uricase inside a plastic vial for uric acid determination in serum and urine. ( 24717661 )
2014
43
Activity and stability of uricase from Lactobacillus plantarum immobilizated on natural zeolite for uric acid biosensor. ( 24783814 )
2014
44
Enhancing performance of uricase using multiwalled carbon nanotube doped polyaniline. ( 24928549 )
2014
45
Construction of an uricase nanoparticles modified au electrode for amperometric determination of uric acid. ( 25141984 )
2014
46
Isolation of a novel uric-acid-degrading microbe Comamonas sp. BT UA and rapid biosensing of uric acid from extracted uricase enzyme. ( 25431410 )
2014
47
PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation. ( 23215688 )
2013
48
Thermal inactivation of uricase (urate oxidase): mechanism and effects of additives. ( 23237426 )
2013
49
Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. ( 23303409 )
2013
50
Preparing a new biosensor for hypoxanthine determination by immobilization of xanthine oxidase and uricase in polypyrrole-polyvinyl sulphonate film. ( 23305069 )
2013

Variations for Urate Oxidase, Pseudogene

Expression for Urate Oxidase, Pseudogene

Search GEO for disease gene expression data for Urate Oxidase, Pseudogene.

Pathways for Urate Oxidase, Pseudogene

GO Terms for Urate Oxidase, Pseudogene

Sources for Urate Oxidase, Pseudogene

3 CDC
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10 dbSNP
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63 PubMed
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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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