Urate Oxidase, Pseudogene disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Urate Oxidase, Pseudogene

MalaCards integrated aliases for Urate Oxidase, Pseudogene:

Name: Urate Oxidase, Pseudogene ⁵⁸ ¹³

Uricase ⁵⁸

Uox ⁵⁸

External Ids:

OMIM ⁵⁸ 191540

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Summaries for Urate Oxidase, Pseudogene

OMIM : ⁵⁸ In most mammals, the activity of urate oxidase (EC 1.7.3.3) catalyzes the oxidation of uric acid to allantoin; humans and some primates lack this enzyme activity. The loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia, a metabolic disturbance that can lead to gouty arthritis and renal stones (summary by Wu et al., 1994). (191540)

MalaCards based summary : Urate Oxidase, Pseudogene, also known as uricase, is related to gout and hyperuricemia. An important gene associated with Urate Oxidase, Pseudogene is UOX (Urate Oxidase (Pseudogene)). The drugs Rasburicase and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney.

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Related Diseases for Urate Oxidase, Pseudogene

Diseases related to Urate Oxidase, Pseudogene via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	gout	10.5
2	hyperuricemia	10.5
3	lymphoma, hodgkin, classic	10.2
4	lymphoma, non-hodgkin, familial	10.2
5	lymphoma	10.2
6	diabetes insipidus	10.2
7	nephrolithiasis, calcium oxalate	10.0
8	nephrolithiasis	10.0
9	spinal muscular atrophy	10.0
10	proximal spinal muscular atrophy	10.0

Graphical network of the top 20 diseases related to Urate Oxidase, Pseudogene:

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Symptoms & Phenotypes for Urate Oxidase, Pseudogene

Clinical features from OMIM:

191540

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Drugs & Therapeutics for Urate Oxidase, Pseudogene

Drugs for Urate Oxidase, Pseudogene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Rasburicase

Approved, Investigational

Phase 3,Phase 2,Phase 1,Not Applicable

134774-45-1

2

Antirheumatic Agents

Phase 3,Phase 2,Phase 1,Not Applicable

3

Allopurinol

Approved

Phase 2

315-30-0

2094

Synonyms:

1,5-dihydro-4H-pyrazolo(3,4-D)Pyrimidin-4-one

1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one

1,5-dihydro-4H-pyrazolo(3,4-D)Pyrimidine-4-one

1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidine-4-one

184856-42-6

1H-pyrazolo(3,4-D)Pyrimidin-4-ol

1H-Pyrazolo(3,4-d)pyrimidin-4-ol

22767-92-6

315-30-0

39464-14-7

4-HPP

4H-pyrazolo(3,4-D)Pyrimidin-4-one

4H-Pyrazolo(3,4-d)pyrimidin-4-one

4-Hydroxy-1H-pyrazolo(3,4-d)pyrimidine

4-Hydroxy-1H-pyrazolo(3,4-D)pyrimidine

4-Hydroxy-3,4-pyrazolopyrimidine

4-hydroxypyrazolo(3,4-D)Pyrimidine

4-Hydroxypyrazolo(3,4-d)pyrimidine

4'-Hydroxypyrazolol(3,4-d)pyrimidine

4'-Hydroxypyrazolol(3,4-D)pyrimidine

4-Hydroxypyrazolopyrimidine

4-Hydroxypyrazolyl(3,4-d)pyrimidine

4-Hydroxypyrazolyl(3,4-D)pyrimidine

7HP

A 8003

A0907

A8003_SIGMA

AC-019

AC1L1CWL

AC1Q6FWV

AC1Q6GP7

Adenock

Ailural

Ailurial

AKOS000267490

AKOS000269759

AL-100

Allohexal

Allohexan

Alloprin

Allopur

Allo-Puren

Allopurin

allopurinol

Allopurinol

Allopurinol alphapharm brand

Allopurinol amrad brand

Allopurinol aps brand

Allopurinol ashbourne brand

Allopurinol azupharma brand

Allopurinol basf brand

Allopurinol bicther brand

Allopurinol boots brand

Allopurinol clonmel brand

Allopurinol dorsch brand

Allopurinol douglas brand

Allopurinol gepepharm brand

Allopurinol hennig brand

Allopurinol hexal brand

Allopurinol horner brand

Allopurinol icn brand

Allopurinol jenapharm brand

Allopurinol merckle brand

Allopurinol merz brand

Allopurinol multipharma brand

Allopurinol nicholas brand

Allopurinol novopharm brand

Allopurinol pharmafarm brand

Allopurinol pinewood brand

Allopurinol protea brand

Allopurinol r.a.n. brand

Allopurinol rima brand

Allopurinol roche brand

Allopurinol rosen brand

Allopurinol rougier brand

Allopurinol Sodium

Allopurinol tad brand

Allopurinol thiemann brand

Allopurinol wellcome brand

Allopurinol(I)

Allopurinolum

Allopurinolum [INN-Latin]

Allorin

Allozym

Allpargin

Allural

Aloprim

Alopurinol

Alopurinol [INN-Spanish]

Aloral

Alositol

Alphapharm brand OF allopurinol

Aluline

Amrad brand OF allopurinol

Anoprolin

Anzief

Apo-Allopurinol

APS brand OF allopurinol

Apulonga

Apurin

Apurol

Ashbourne brand OF allopurinol

Atisuril

Azupharma brand OF allopurinol

B. W. 56-158

BASF brand OF allopurinol

BB_SC-5394

Bicther brand OF allopurinol

BIM-0061756.0001

Bio-0799

Bleminol

Bloxanth

Boehringer mannheim brand OF allopurinol

Boots brand OF allopurinol

BSPBio_001798

BW 56158

BW 56-158

BW-56-158

Byk gulden brand OF allopurinol

C5H4N4O

Caplenal

Capurate

CCRIS 626

Cellidrin

CHEBI:40279

CHEBI:495607

CHEMBL1467

CID2094

Clonmel brand OF allopurinol

Cosuric

CPD000059083

CPD-9024

D000493

Dabrosin

Dabroson

DB00437

DivK1c_000685

Dorsch brand OF allopurinol

Douglas brand OF allopurinol

Dura Al

EINECS 206-250-9

Embarin

EN000932

Epidropal

Epuric

EU-0100102

Fawns and mcallan brand OF allopurinol

Foligan

Geapur

Gepepharm brand OF allopurinol

Gichtex

glaxo Wellcome brand OF allopurinol

Gotax

Hamarin

Hennig brand OF allopurinol

Henning berlin brand OF allopurinol

Hexal brand OF allopurinol

Hexanuret

HMS1920A15

HMS2091G15

HMS502C07

Horner brand OF allopurinol

HPP

HSDB 3004

I03-0052

ICN brand OF allopurinol

IDI1_000685

Jenapharm brand OF allopurinol

Jenapurinol

Jsp005881

KBio1_000685

KBio2_000386

KBio2_002954

KBio2_005522

KBio3_001298

KBioGR_000550

KBioSS_000386

Ketanrift

Ketobun-A

Ledopur

Lopac0_000102

Lopac-A-8003

Lopurin

LS-1180

Lysuron

Merckle brand OF allopurinol

Merz brand OF allopurinol

Milurit

Milurite

Miniplanor

MLS000069453

MLS001148183

MolPort-000-141-383

MolPort-000-870-337

MolPort-004-758-159

MolPort-004-758-166

MolPort-004-758-167

MolPort-004-758-643

Monarch

Multipharma brand OF allopurinol

NCGC00015094-01

NCGC00015094-03

NCGC00015094-06

NCGC00091134-01

NCGC00091134-02

NCGC00091134-03

NCGC00094580-01

NCGC00094580-02

nchembio.92-comp3

nchembio732-comp4

NCIOpen2_001825

Nektrohan

Nicholas brand OF allopurinol

NINDS_000685

Novopharm brand OF allopurinol

Novopurol

NSC 101655

NSC 1390

NSC101655

NSC1390

NSC-1390

Pan quimica

Pan Quimica

Pharmafarm brand OF allopurinol

Pinewood brand OF allopurinol

Prestwick_511

Progout

Protea brand OF allopurinol

Pureduct

Purinol

Quimica, pan

Quimica, Pan

R.A.N. brand OF allopurinol

Reig jofre brand OF allopurinol

Remid

Rhône poulenc rorer brand OF allopurinol

Rhône-poulenc rorer brand OF allopurinol

Riball

Rima brand OF allopurinol

Rimapurinol

Roche brand OF allopurinol

Rosen brand OF allopurinol

Roucol

Rougier brand OF allopurinol

S1630_Selleck

SAM002554884

Sigapurol

SMR000059083

SPBio_000056

Spectrum_000026

SPECTRUM1500108

Spectrum2_000098

Spectrum3_000289

Spectrum4_000135

Spectrum5_000768

STK378584

STK711106

Suspendol

TAD brand OF allopurinol

Takanarumin

Thiemann brand OF allopurinol

Tipuric

UNII-63CZ7GJN5I

Urbol

Uribenz

Uricemil

Uridocid

Uriprim

Uripurinol

Uritas

Urobenyl

Urolit

Urosin

Urtias

Urtias 100

Wellcome brand OF allopurinol

Xanthomax

Xanturat

Xanturic

Zygout

Zyloprim

Zyloric

4

Uric acid

Investigational

Phase 2,Phase 1,Not Applicable

69-93-2

1175

Synonyms:

1H-Purine-2,6,8-triol

2,6,8-trihydroxypurine

2,6,8-Trihydroxypurine

2,6,8-trioxopurine

2,6,8-Trioxopurine

2,6,8-trioxypurine

2,6,8-Trioxypurine

7,9-dihydro-1H-purine-2,6,8(3H)-trione

Acid urate, ammonium

Acid urate, sodium

Acid, uric

Ammonium acid urate

Lithate

Lithic acid

Monohydrate, monosodium urate

Monohydrate, sodium urate

Monosodium urate

Monosodium urate monohydrate

Potassium urate

Purine-2,6,8(1H,3H,9H)-trione

Sodium acid urate

Sodium acid urate monohydrate

Sodium urate

Sodium urate monohydrate

Trioxopurine

Urate

Urate monohydrate, monosodium

Urate monohydrate, sodium

Urate, ammonium acid

Urate, monosodium

Urate, potassium

Urate, sodium

Urate, sodium acid

Uricum acidum

5

Protective Agents

Phase 2,Phase 1,Not Applicable

6

Antioxidants

Phase 2,Phase 1,Not Applicable

7

Febuxostat

Approved

Not Applicable

144060-53-7

134018

Synonyms:

111GE013

144060-53-7

2-(3-Cyano-4-(2-methylpropoxy)phenyl)-4-methylthiazole-5-carboxylic acid

2-(3-cyano-4-isobutoxyphenyl)-4-methyl- 1,3-thiazole-5-carboxylic acid

2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic acid

2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID

2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid

AC1L33UC

AC-425

Adenuric

C16H16N2O3S

CHEBI:45943

CHEBI:747206

CHEMBL1164729

CID134018

D01206

DB03786

Febuxostat

Fébuxostat

Febuxostat (JAN/USAN/INN)

Febuxostat [USAN]

Febuxostatum

FT-0081351

LS-173202

MolPort-005-940-740

S1547

S1547_Selleck

TEI

Tei 6720

Tei-6720

TMX 67

TMX-67

TMX-67, Adenuric, Uloric, Febuxostat

Uloric

UNII-101V0R1N2E

8

Hypoglycemic Agents

Not Applicable

9

Insulin, Globin Zinc

Not Applicable

10

insulin

Not Applicable

11

Flax

Not Applicable

12

Pharmaceutical Solutions

Not Applicable

Interventional clinical trials:

(show all 15)

#	Name	Status	NCT ID	Phase	Drugs
1	Safety and Efficacy Study of PEG-uricase in the Treatment of Hyperuricemic Patients With Symptomatic Gout	Completed	NCT00325195	Phase 3
2	Open-Label Extension Study for Patients Who Completed a Phase 3 Double-blind Study of PEG-uricase for Symptomatic Gout	Completed	NCT01356498	Phase 3
3	Pegylated Recombinant Mammalian Uricase (PEG-uricase) as Treatment for Refractory Gout	Completed	NCT00111657	Phase 2
4	A Study to Compare the Efficacy of SEL-212 to KRYSTEXXA® in Gout Patients Refractory to Conventional Therapy	Recruiting	NCT03905512	Phase 2	SEL-212;SEL-037;SEL-110;KRYSTEXXA®
5	Uric Acid Lowering Trial in Youth Onset T2D	Not yet recruiting	NCT03899883	Phase 2	Pegloticase 8 MG/ML [Krystexxa]
6	Safety and Efficacy Study of Intramuscular Uricase-PEG 20	Unknown status	NCT01038947	Phase 1
7	Safety and Efficacy Study of Intravenous Uricase-PEG 20	Unknown status	NCT01021241	Phase 1
8	Safety and Pharmacodynamics of SEL-037 (Pegsiticase) in Subjects With Elevated Blood Uric Acid Levels	Completed	NCT02464605	Phase 1
9	Safety and Pharmacodynamics of SEL-212 (Pegsiticase + SEL-110) in Subjects With Elevated Blood Uric Acid Levels	Completed	NCT02648269	Phase 1	SEL-110
10	A Study to Assess the Safety and Tolerability of SSS11 in Healthy Subjects.	Recruiting	NCT03388515	Phase 1
11	Study of Association Between Maternal Uric Acid , Maternal and Fetal Outcome in Pregnant Women With Hypertension	Unknown status	NCT01523327
12	Study of the Reliability of a Device (HumanSens Plus) Allowing Immediate Measurement Uric Acid in the Blood Obtained by Finger Tip Puncture.	Unknown status	NCT02671656
13	Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status	Completed	NCT01931527	Not Applicable	Rasburicase
14	Impact of Flaxseed on the Syndrome Metabolic Inflammation	Completed	NCT02132728	Not Applicable
15	Uric Acid Effects on Endothelium and Oxydative Stress	Recruiting	NCT03395977	Not Applicable	Placebos;Febuxostat;Rasburicase

Search NIH Clinical Center for Urate Oxidase, Pseudogene

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Genetic Tests for Urate Oxidase, Pseudogene

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Anatomical Context for Urate Oxidase, Pseudogene

MalaCards organs/tissues related to Urate Oxidase, Pseudogene:

⁴²

Kidney

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Publications for Urate Oxidase, Pseudogene

Articles related to Urate Oxidase, Pseudogene:

#	Title	Authors	Year
1	Probing the Electronic Structure and Chemical Bonding of Mono-Uranium Oxides with Different Oxidation States: UOx(-) and UOx (x = 3-5). ( 26825216 )	Su J...Li J	2016
2	Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury. ( 27906636 )	Hosoyamada M...Uchida S	2016
3	Complexed and ligand-free high-resolution structures of urate oxidase (Uox) from Aspergillus flavus: a reassignment of the active-site binding mode. ( 14993669 )	Retailleau P...Prang? T	2004
4	The mouse urate oxidase gene, Uox, maps to distal chromosome 3. ( 9250879 )	Cook S...Davisson M	1997
5	Study of pH and temperature-induced transitions in urate oxidase (Uox-EC1.7.3.3) by microcalorimetry (DSC), size exclusion chromatography (SEC) and enzymatic activity experiments. ( 17020862 )	Bayol A...L?toff? JM	1995
6	Localization of the human urate oxidase gene (UOX) to 1p22. ( 1395718 )	Yeldandi AV...Le Beau MM	1992

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Genes for Urate Oxidase, Pseudogene

Genes related to Urate Oxidase, Pseudogene (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	UOX	Urate Oxidase (Pseudogene)	Pseudogene	66.96	Typically genetic variations that lead to apparently abnormal laboratory test values ⁵⁸ GeneCards inferred via : Gene name Transcripts (show sections)

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Variations for Urate Oxidase, Pseudogene

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Expression for Urate Oxidase, Pseudogene

Search GEO for disease gene expression data for Urate Oxidase, Pseudogene.

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Pathways for Urate Oxidase, Pseudogene

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GO Terms for Urate Oxidase, Pseudogene

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Urate Oxidase, Pseudogene (UOX)

Aliases & Classifications for Urate Oxidase, Pseudogene

MalaCards integrated aliases for Urate Oxidase, Pseudogene:

External Ids:

Summaries for Urate Oxidase, Pseudogene

Related Diseases for Urate Oxidase, Pseudogene

Diseases related to Urate Oxidase, Pseudogene via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Urate Oxidase, Pseudogene:

Symptoms & Phenotypes for Urate Oxidase, Pseudogene

Clinical features from OMIM:

Drugs & Therapeutics for Urate Oxidase, Pseudogene

Drugs for Urate Oxidase, Pseudogene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Urate Oxidase, Pseudogene

Anatomical Context for Urate Oxidase, Pseudogene

MalaCards organs/tissues related to Urate Oxidase, Pseudogene:

Publications for Urate Oxidase, Pseudogene

Articles related to Urate Oxidase, Pseudogene:

Genes for Urate Oxidase, Pseudogene

Genes related to Urate Oxidase, Pseudogene (1 elite genes):

Variations for Urate Oxidase, Pseudogene

Expression for Urate Oxidase, Pseudogene

Pathways for Urate Oxidase, Pseudogene

GO Terms for Urate Oxidase, Pseudogene

Sources for Urate Oxidase, Pseudogene