UOX
MCID: URT049
MIFTS: 18

Urate Oxidase, Pseudogene (UOX)

Aliases & Classifications for Urate Oxidase, Pseudogene

MalaCards integrated aliases for Urate Oxidase, Pseudogene:

Name: Urate Oxidase, Pseudogene 58 13
Uricase 58
Uox 58

External Ids:

OMIM 58 191540

Summaries for Urate Oxidase, Pseudogene

OMIM : 58 In most mammals, the activity of urate oxidase (EC 1.7.3.3) catalyzes the oxidation of uric acid to allantoin; humans and some primates lack this enzyme activity. The loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia, a metabolic disturbance that can lead to gouty arthritis and renal stones (summary by Wu et al., 1994). (191540)

MalaCards based summary : Urate Oxidase, Pseudogene, also known as uricase, is related to gout and hyperuricemia. An important gene associated with Urate Oxidase, Pseudogene is UOX (Urate Oxidase (Pseudogene)). The drugs Rasburicase and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney.

Related Diseases for Urate Oxidase, Pseudogene

Diseases related to Urate Oxidase, Pseudogene via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 gout 10.5
2 hyperuricemia 10.5
3 lymphoma, hodgkin, classic 10.2
4 lymphoma, non-hodgkin, familial 10.2
5 lymphoma 10.2
6 diabetes insipidus 10.2
7 nephrolithiasis, calcium oxalate 10.0
8 nephrolithiasis 10.0
9 spinal muscular atrophy 10.0
10 proximal spinal muscular atrophy 10.0

Graphical network of the top 20 diseases related to Urate Oxidase, Pseudogene:



Diseases related to Urate Oxidase, Pseudogene

Symptoms & Phenotypes for Urate Oxidase, Pseudogene

Clinical features from OMIM:

191540

Drugs & Therapeutics for Urate Oxidase, Pseudogene

Drugs for Urate Oxidase, Pseudogene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rasburicase Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 134774-45-1
2 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
3
Allopurinol Approved Phase 2 315-30-0 2094
4
Uric acid Investigational Phase 2,Phase 1,Not Applicable 69-93-2 1175
5 Protective Agents Phase 2,Phase 1,Not Applicable
6 Antioxidants Phase 2,Phase 1,Not Applicable
7
Febuxostat Approved Not Applicable 144060-53-7 134018
8 Hypoglycemic Agents Not Applicable
9 Insulin, Globin Zinc Not Applicable
10 insulin Not Applicable
11 Flax Not Applicable
12 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of PEG-uricase in the Treatment of Hyperuricemic Patients With Symptomatic Gout Completed NCT00325195 Phase 3
2 Open-Label Extension Study for Patients Who Completed a Phase 3 Double-blind Study of PEG-uricase for Symptomatic Gout Completed NCT01356498 Phase 3
3 Pegylated Recombinant Mammalian Uricase (PEG-uricase) as Treatment for Refractory Gout Completed NCT00111657 Phase 2
4 A Study to Compare the Efficacy of SEL-212 to KRYSTEXXA® in Gout Patients Refractory to Conventional Therapy Recruiting NCT03905512 Phase 2 SEL-212;SEL-037;SEL-110;KRYSTEXXA®
5 Uric Acid Lowering Trial in Youth Onset T2D Not yet recruiting NCT03899883 Phase 2 Pegloticase 8 MG/ML [Krystexxa]
6 Safety and Efficacy Study of Intramuscular Uricase-PEG 20 Unknown status NCT01038947 Phase 1
7 Safety and Efficacy Study of Intravenous Uricase-PEG 20 Unknown status NCT01021241 Phase 1
8 Safety and Pharmacodynamics of SEL-037 (Pegsiticase) in Subjects With Elevated Blood Uric Acid Levels Completed NCT02464605 Phase 1
9 Safety and Pharmacodynamics of SEL-212 (Pegsiticase + SEL-110) in Subjects With Elevated Blood Uric Acid Levels Completed NCT02648269 Phase 1 SEL-110
10 A Study to Assess the Safety and Tolerability of SSS11 in Healthy Subjects. Recruiting NCT03388515 Phase 1
11 Study of Association Between Maternal Uric Acid , Maternal and Fetal Outcome in Pregnant Women With Hypertension Unknown status NCT01523327
12 Study of the Reliability of a Device (HumanSens Plus) Allowing Immediate Measurement Uric Acid in the Blood Obtained by Finger Tip Puncture. Unknown status NCT02671656
13 Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status Completed NCT01931527 Not Applicable Rasburicase
14 Impact of Flaxseed on the Syndrome Metabolic Inflammation Completed NCT02132728 Not Applicable
15 Uric Acid Effects on Endothelium and Oxydative Stress Recruiting NCT03395977 Not Applicable Placebos;Febuxostat;Rasburicase

Search NIH Clinical Center for Urate Oxidase, Pseudogene

Genetic Tests for Urate Oxidase, Pseudogene

Anatomical Context for Urate Oxidase, Pseudogene

MalaCards organs/tissues related to Urate Oxidase, Pseudogene:

42
Kidney

Publications for Urate Oxidase, Pseudogene

Articles related to Urate Oxidase, Pseudogene:

# Title Authors Year
1
Probing the Electronic Structure and Chemical Bonding of Mono-Uranium Oxides with Different Oxidation States: UOx(-) and UOx (x = 3-5). ( 26825216 )
2016
2
Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury. ( 27906636 )
2016
3
Complexed and ligand-free high-resolution structures of urate oxidase (Uox) from Aspergillus flavus: a reassignment of the active-site binding mode. ( 14993669 )
2004
4
The mouse urate oxidase gene, Uox, maps to distal chromosome 3. ( 9250879 )
1997
5
Study of pH and temperature-induced transitions in urate oxidase (Uox-EC1.7.3.3) by microcalorimetry (DSC), size exclusion chromatography (SEC) and enzymatic activity experiments. ( 17020862 )
1995
6
Localization of the human urate oxidase gene (UOX) to 1p22. ( 1395718 )
1992

Variations for Urate Oxidase, Pseudogene

Expression for Urate Oxidase, Pseudogene

Search GEO for disease gene expression data for Urate Oxidase, Pseudogene.

Pathways for Urate Oxidase, Pseudogene

GO Terms for Urate Oxidase, Pseudogene

Sources for Urate Oxidase, Pseudogene

3 CDC
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63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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