Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
UOX
MCID: URT049
MIFTS: 20

Urate Oxidase, Pseudogene (UOX)

Genes Tissues Related diseases Publications Drugs
Sources

Aliases & Classifications for Urate Oxidase, Pseudogene

About this section

MalaCards integrated aliases for Urate Oxidase, Pseudogene:

Name: Urate Oxidase, Pseudogene 57 13
Uricase 57
Uox 57

External Ids:

OMIM 57 191540
Sources

Summaries for Urate Oxidase, Pseudogene

About this section
OMIM : 57 In most mammals, the activity of urate oxidase (EC 1.7.3.3) catalyzes the oxidation of uric acid to allantoin; humans and some primates lack this enzyme activity. The loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia, a metabolic disturbance that can lead to gouty arthritis and renal stones (summary by Wu et al., 1994). (191540)

MalaCards based summary : Urate Oxidase, Pseudogene, also known as uricase, is related to gout and hyperuricemia. An important gene associated with Urate Oxidase, Pseudogene is UOX (Urate Oxidase (Pseudogene)). The drugs Rasburicase and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lung.

Sources

Related Diseases for Urate Oxidase, Pseudogene

About this section

Diseases related to Urate Oxidase, Pseudogene via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 gout 10.5
2 hyperuricemia 10.4
3 lymphoma, hodgkin, classic 10.1
4 lymphoma, non-hodgkin, familial 10.1
5 lymphoma 10.1
6 diabetes insipidus 10.1
7 nephrolithiasis, calcium oxalate 10.0
8 nephrolithiasis 10.0
9 spinal muscular atrophy 10.0
10 proximal spinal muscular atrophy 10.0

Graphical network of the top 20 diseases related to Urate Oxidase, Pseudogene:



Diseases related to Urate Oxidase, Pseudogene
Sources

Symptoms & Phenotypes for Urate Oxidase, Pseudogene

About this section

Clinical features from OMIM:

191540
Sources

Drugs & Therapeutics for Urate Oxidase, Pseudogene

About this section

Drugs for Urate Oxidase, Pseudogene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rasburicase Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 134774-45-1
2 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
3
Allopurinol Approved Phase 2 315-30-0 2094
4
Uric Acid Experimental, Investigational Phase 2,Phase 1,Not Applicable 69-93-2 1175
5 Antioxidants Phase 1,Not Applicable
6 Protective Agents Phase 1,Not Applicable
7
Febuxostat Approved Not Applicable 144060-53-7 134018
8 insulin Not Applicable
9 Insulin, Globin Zinc Not Applicable
10 Hypoglycemic Agents Not Applicable
11 Flax Not Applicable
12 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of PEG-uricase in the Treatment of Hyperuricemic Patients With Symptomatic Gout Completed NCT00325195 Phase 3
2 Open-Label Extension Study for Patients Who Completed a Phase 3 Double-blind Study of PEG-uricase for Symptomatic Gout Completed NCT01356498 Phase 3
3 Pegylated Recombinant Mammalian Uricase (PEG-uricase) as Treatment for Refractory Gout Completed NCT00111657 Phase 2
4 Safety and Efficacy Study of Intramuscular Uricase-PEG 20 Unknown status NCT01038947 Phase 1
5 Safety and Efficacy Study of Intravenous Uricase-PEG 20 Unknown status NCT01021241 Phase 1
6 Safety and Pharmacodynamics of SEL-037 (Pegsiticase) in Subjects With Elevated Blood Uric Acid Levels Completed NCT02464605 Phase 1
7 Safety and Pharmacodynamics of SEL-212 (Pegsiticase + SEL-110) in Subjects With Elevated Blood Uric Acid Levels Completed NCT02648269 Phase 1 SEL-110
8 A Study to Assess the Safety and Tolerability of SSS11 in Healthy Subjects. Recruiting NCT03388515 Phase 1
9 Study of Association Between Maternal Uric Acid , Maternal and Fetal Outcome in Pregnant Women With Hypertension Unknown status NCT01523327
10 Study of the Reliability of a Device (HumanSens Plus) Allowing Immediate Measurement Uric Acid in the Blood Obtained by Finger Tip Puncture. Unknown status NCT02671656
11 Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status Completed NCT01931527 Not Applicable Rasburicase
12 Impact of Flaxseed on the Syndrome Metabolic Inflammation Completed NCT02132728 Not Applicable
13 Uric Acid Effects on Endothelium and Oxydative Stress Recruiting NCT03395977 Not Applicable Placebos;Febuxostat;Rasburicase

Search NIH Clinical Center for Urate Oxidase, Pseudogene

Sources

Genetic Tests for Urate Oxidase, Pseudogene

About this section
Sources

Anatomical Context for Urate Oxidase, Pseudogene

About this section

MalaCards organs/tissues related to Urate Oxidase, Pseudogene:

41
Liver, Kidney, Lung, Testes
Sources

Publications for Urate Oxidase, Pseudogene

About this section

Articles related to Urate Oxidase, Pseudogene:

(show top 50) (show all 287)
# Title Authors Year
1
Optimization of novel and greener approach for the coproduction of uricase and alkaline protease in Bacillus licheniformis by Box-Behnken model. ( 28976246 )
2018
2
Dextrin-uricase conjugate: Preparation, characterization, and enzymatic properties. ( 29292142 )
2018
3
Uricase-free on-demand colorimetric biosensing of uric acid enabled by integrated CoP nanosheet arrays as a monolithic peroxidase mimic. ( 29681277 )
2018
4
Ultrasound assisted process intensification of uricase and alkaline protease enzyme co-production in Bacillus licheniformis. ( 29705310 )
2018
5
Efficient purification of a recombinant tag-free thermostable Kluyveromyces marxianus uricase by pH-induced self-cleavage of intein and expression in Escherichia coli. ( 30221113 )
2018
6
Antioxidant properties of citric acid interfere with the uricase-based measurement of circulating uric acid. ( 30447534 )
2018
7
Erratum: Uricase alkaline enzymosomes with enhanced stabilities and anti-hyperuricemia effects induced by favorable microenvironmental changes. ( 28664903 )
2017
8
Effect of surfactants and inducers on increased uricase production under submerged fermentations by Bacillus cereus. ( 27071031 )
2017
9
A Practical System for High-Throughput Screening of Mutants of Bacillus fastidiosus Uricase. ( 27614625 )
2017
10
Impact of Mutations on the Higher Order Structure and Activity of a Recombinant Uricase. ( 28063825 )
2017
11
Oral uricase eliminates blood uric acid in the hyperuricemic pig model. ( 28594873 )
2017
12
Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid. ( 28890842 )
2017
13
Designing a mutant Candida uricase with improved polymerization state and enzymatic activity. ( 29161434 )
2017
14
Uricase based fluorometric determination of uric acid based on the use of graphene quantum dot@silver core-shell nanocomposites. ( 29594655 )
2017
15
Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout. ( 27352852 )
2016
16
Uricase alkaline enzymosomes with enhanced stabilities and anti-hyperuricemia effects induced by favorable microenvironmental changes. ( 26823332 )
2016
17
DNA shuffling of uricase gene leads to a more "human like" chimeric uricase with increased uricolytic activity. ( 26526169 )
2016
18
Economic analysis of uricase production under uncertainty: Contrast of chromatographic purification and aqueous two-phase extraction (with and without PEG recycle). ( 26561271 )
2016
19
Development of Therapeutic Chimeric Uricase by Exon Replacement/Restoration and Site-Directed Mutagenesis. ( 27213357 )
2016
20
Electrochemical detection of uric acid via uricase-immobilized graphene oxide. ( 27402177 )
2016
21
Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism. ( 27465529 )
2016
22
A Numerical Approach for Kinetic Analysis of the Nonexponential Thermoinactivation Process of Uricase. ( 27480193 )
2016
23
Utilizing intein-mediated protein cleaving for purification of uricase, a multimeric enzyme. ( 27702489 )
2016
24
Urinary excretion of uric acid, allantoin, and 8-OH-Deoxyguanosine in uricase-knockout mice. ( 27906613 )
2016
25
A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties. ( 28002433 )
2016
26
A novel third generation uric acid biosensor using uricase electro-activated with ferrocene on a Nafion coated glassy carbon electrode. ( 25461755 )
2015
27
Cloning, Expression, and Purification of Recombinant Uricase Enzyme from Pseudomonas aeruginosa Ps43 Using Escherichia coli. ( 25588559 )
2015
28
Enhancement of a novel extracellular uricase production by media optimization and partial purification by aqueous three-phase system. ( 25674929 )
2015
29
Purification, characterization and in vitro application of a thermostable oxidant- and SDS-stable uricase from a newly isolated Bacillus firmus DWD-33. ( 25742044 )
2015
30
Crystal structure of Bacillus fastidious uricase reveals an unexpected folding of the C-terminus residues crucial for thermostability under physiological conditions. ( 25786739 )
2015
31
Characterization of a Thermostable Uricase Isolated from Bacillus firmus DWD-33 and its Application for Uric Acid Quantification in Human Serum. ( 25981580 )
2015
32
Purification and characterization of an extracellular uricase from a new isolate of Sphingobacterium thalpophilum (VITPCB5). ( 26145833 )
2015
33
Isolation, screening and production studies of uricase producing bacteria from poultry sources. ( 24279683 )
2014
34
Comparison of modification of a bacterial uricase with N-hydroxysuccinimide esters of succinate and carbonate of monomethoxyl poly(ethylene glycol). ( 24512141 )
2014
35
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD. ( 24643131 )
2014
36
Covalent immobilization of uricase inside a plastic vial for uric acid determination in serum and urine. ( 24717661 )
2014
37
Activity and stability of uricase from Lactobacillus plantarum immobilizated on natural zeolite for uric acid biosensor. ( 24783814 )
2014
38
Enhancing performance of uricase using multiwalled carbon nanotube doped polyaniline. ( 24928549 )
2014
39
Construction of an uricase nanoparticles modified au electrode for amperometric determination of uric acid. ( 25141984 )
2014
40
Infusion-related reactions with pegloticase, a recombinant uricase for the treatment of chronic gout refractory to conventional therapy. ( 25417679 )
2014
41
Isolation of a novel uric-acid-degrading microbe Comamonas sp. BT UA and rapid biosensing of uric acid from extracted uricase enzyme. ( 25431410 )
2014
42
PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation. ( 23215688 )
2013
43
Thermal inactivation of uricase (urate oxidase): mechanism and effects of additives. ( 23237426 )
2013
44
Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. ( 23303409 )
2013
45
Preparing a new biosensor for hypoxanthine determination by immobilization of xanthine oxidase and uricase in polypyrrole-polyvinyl sulphonate film. ( 23305069 )
2013
46
Comparison of activity indexes for recognizing enzyme mutants of higher activity with uricase as model. ( 23594729 )
2013
47
Immbolization of uricase enzyme in Langmuir and Langmuir-Blodgett films of fatty acids: possible use as a uric acid sensor. ( 21875709 )
2012
48
Uricase-adsorbed carbon-felt reactor coupled with a peroxidase-modified carbon-felt-based H2O2 detector for highly sensitive amperometric flow determination of uric acid. ( 21906900 )
2012
49
Construction of amperometric uric acid biosensor based on uricase immobilized on PBNPs/cMWCNT/PANI/Au composite. ( 22020190 )
2012
50
Characterization, efficacy, pharmacokinetics, and biodistribution of 5kDa mPEG modified tetrameric canine uricase variant. ( 22503989 )
2012
Sources

Variations for Urate Oxidase, Pseudogene

About this section
Sources

Expression for Urate Oxidase, Pseudogene

About this section
Search GEO for disease gene expression data for Urate Oxidase, Pseudogene.
Sources

Pathways for Urate Oxidase, Pseudogene

About this section
Sources

GO Terms for Urate Oxidase, Pseudogene

About this section
Sources

Sources for Urate Oxidase, Pseudogene

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....