Aliases & Classifications for Urate Oxidase, Pseudogene

MalaCards integrated aliases for Urate Oxidase, Pseudogene:

Name: Urate Oxidase, Pseudogene 57 13
Uricase 57
Uox 57

External Ids:

OMIM 57 191540
MedGen 42 C3887994
SNOMED-CT via HPO 69 35885006

Summaries for Urate Oxidase, Pseudogene

OMIM : 57 In most mammals, the activity of urate oxidase (EC 1.7.3.3) catalyzes the oxidation of uric acid to allantoin; humans and some primates lack this enzyme activity. The loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia, a metabolic disturbance that can lead to gouty arthritis and renal stones (summary by Wu et al., 1994). (191540)

MalaCards based summary : Urate Oxidase, Pseudogene, also known as uricase, is related to gout and hyperuricemia. An important gene associated with Urate Oxidase, Pseudogene is UOX (Urate Oxidase (Pseudogene)). The drugs Rasburicase and Antirheumatic Agents have been mentioned in the context of this disorder. Related phenotype is hyperuricemia.

Related Diseases for Urate Oxidase, Pseudogene

Diseases related to Urate Oxidase, Pseudogene via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 gout 10.3
2 hyperuricemia 10.1
3 diabetes insipidus 10.0
4 hepatitis 9.9

Symptoms & Phenotypes for Urate Oxidase, Pseudogene

Clinical features from OMIM:

191540

Human phenotypes related to Urate Oxidase, Pseudogene:

32
# Description HPO Frequency HPO Source Accession
1 hyperuricemia 32 HP:0002149

Drugs & Therapeutics for Urate Oxidase, Pseudogene

Drugs for Urate Oxidase, Pseudogene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rasburicase Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 134774-45-1
2 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
3
Allopurinol Approved Phase 2 315-30-0 2094
4
Uric Acid Experimental, Investigational Phase 2,Phase 1,Not Applicable 69-93-2 1175
5 Antioxidants Phase 1,Not Applicable
6 Protective Agents Phase 1,Not Applicable
7
Febuxostat Approved Not Applicable 144060-53-7 134018
8 Hypoglycemic Agents Not Applicable
9 insulin Not Applicable
10 Insulin, Globin Zinc Not Applicable
11 Pharmaceutical Solutions Not Applicable
12 Flax Nutraceutical Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of PEG-uricase in the Treatment of Hyperuricemic Patients With Symptomatic Gout Completed NCT00325195 Phase 3
2 Open-Label Extension Study for Patients Who Completed a Phase 3 Double-blind Study of PEG-uricase for Symptomatic Gout Completed NCT01356498 Phase 3
3 Pegylated Recombinant Mammalian Uricase (PEG-uricase) as Treatment for Refractory Gout Completed NCT00111657 Phase 2
4 Safety and Efficacy Study of Intramuscular Uricase-PEG 20 Unknown status NCT01038947 Phase 1
5 Safety and Efficacy Study of Intravenous Uricase-PEG 20 Unknown status NCT01021241 Phase 1
6 Safety and Pharmacodynamics of SEL-037 (Pegsiticase) in Subjects With Elevated Blood Uric Acid Levels Completed NCT02464605 Phase 1
7 Safety and Pharmacodynamics of SEL-212 (Pegsiticase + SEL-110) in Subjects With Elevated Blood Uric Acid Levels Completed NCT02648269 Phase 1 SEL-110
8 A Study to Assess the Safety and Tolerability of SSS11 in Healthy Subjects. Recruiting NCT03388515 Phase 1
9 Study of Association Between Maternal Uric Acid , Maternal and Fetal Outcome in Pregnant Women With Hypertension Unknown status NCT01523327
10 Study of the Reliability of a Device (HumanSens Plus) Allowing Immediate Measurement Uric Acid in the Blood Obtained by Finger Tip Puncture. Unknown status NCT02671656
11 Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status Completed NCT01931527 Not Applicable Rasburicase
12 Impact of Flaxseed on the Syndrome Metabolic Inflammation Completed NCT02132728 Not Applicable
13 Uric Acid Effects on Endothelium and Oxydative Stress Recruiting NCT03395977 Not Applicable Placebos;Febuxostat;Rasburicase

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Genetic Tests for Urate Oxidase, Pseudogene

Anatomical Context for Urate Oxidase, Pseudogene

Publications for Urate Oxidase, Pseudogene

Variations for Urate Oxidase, Pseudogene

Expression for Urate Oxidase, Pseudogene

Search GEO for disease gene expression data for Urate Oxidase, Pseudogene.

Pathways for Urate Oxidase, Pseudogene

GO Terms for Urate Oxidase, Pseudogene

Sources for Urate Oxidase, Pseudogene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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