UOX
MCID: URT049
MIFTS: 25

Urate Oxidase, Pseudogene (UOX)

Aliases & Classifications for Urate Oxidase, Pseudogene

MalaCards integrated aliases for Urate Oxidase, Pseudogene:

Name: Urate Oxidase, Pseudogene 56 13
Uricase 56
Uox 56

External Ids:

OMIM 56 191540

Summaries for Urate Oxidase, Pseudogene

OMIM : 56 In most mammals, the activity of urate oxidase (EC 1.7.3.3) catalyzes the oxidation of uric acid to allantoin; humans and some primates lack this enzyme activity. The loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia, a metabolic disturbance that can lead to gouty arthritis and renal stones (summary by Wu et al., 1994). (191540)

MalaCards based summary : Urate Oxidase, Pseudogene, also known as uricase, is related to gout and hyperuricemia. An important gene associated with Urate Oxidase, Pseudogene is UOX (Urate Oxidase (Pseudogene)). The drugs Febuxostat and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and endothelial.

Related Diseases for Urate Oxidase, Pseudogene

Diseases related to Urate Oxidase, Pseudogene via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 18, show less)
# Related Disease Score Top Affiliating Genes
1 gout 10.9
2 hyperuricemia 10.9
3 diabetes insipidus, nephrogenic, autosomal 10.2
4 lymphoma, hodgkin, classic 10.2
5 lymphoma, non-hodgkin, familial 10.2
6 nephrolithiasis 10.2
7 diabetes insipidus 10.2
8 burkitt lymphoma 10.1
9 hepatocellular carcinoma 10.1
10 nephrolithiasis, calcium oxalate 10.1
11 wilms tumor 5 10.1
12 urolithiasis 10.1
13 glucose intolerance 10.1
14 hyperglycemia 10.1
15 uremia 10.1
16 severe combined immunodeficiency 10.1
17 fatty liver disease 10.1
18 rapidly involuting congenital hemangioma 10.1

Graphical network of the top 20 diseases related to Urate Oxidase, Pseudogene:



Diseases related to Urate Oxidase, Pseudogene

Symptoms & Phenotypes for Urate Oxidase, Pseudogene

Clinical features from OMIM:

191540

Drugs & Therapeutics for Urate Oxidase, Pseudogene

Drugs for Urate Oxidase, Pseudogene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 46, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Febuxostat Approved Phase 4 144060-53-7 134018
2
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
3
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
4
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
5
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
8
Polyestradiol phosphate Approved Phase 4 28014-46-2
9
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
10
Uric acid Investigational Phase 4 69-93-2 1175
11 Tocotrienol Investigational Phase 4 6829-55-6
12 Antirheumatic Agents Phase 4
13 Pharmaceutical Solutions Phase 4
14 Protective Agents Phase 4
15 Angiotensinogen Phase 4
16 Giapreza Phase 4
17 Vitamins Phase 4
18 Insulin, Globin Zinc Phase 4
19 Lecithin Phase 4
20 Antihypertensive Agents Phase 4
21 insulin Phase 4
22 Silybin Phase 4
23 Tocopherols Phase 4
24 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
25 Tocotrienols Phase 4
26 Sodium Chloride Symporter Inhibitors Phase 4
27 Progestins Phase 4
28 Estradiol 17 beta-cypionate Phase 4
29 Angiotensin-Converting Enzyme Inhibitors Phase 4
30
protease inhibitors Phase 4
31 Estradiol 3-benzoate Phase 4
32 diuretics Phase 4
33 HIV Protease Inhibitors Phase 4
34 Estrogens Phase 4
35
Allopurinol Approved Phase 2 315-30-0 2094
36
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
37
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
38
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
39 Anti-Infective Agents Phase 2
40 Immunologic Factors Phase 2
41 Immunosuppressive Agents Phase 2
42 Anti-Bacterial Agents Phase 2
43 Antifungal Agents Phase 2
44 Antibiotics, Antitubercular Phase 2
45
Rasburicase Approved, Investigational Phase 1 134774-45-1
46 Antioxidants Phase 1

Interventional clinical trials:

(showing 19, show less)
# Name Status NCT ID Phase Drugs
1 Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS) Completed NCT01328769 Phase 4 Febuxostat;Placebo
2 Metabolic and Vascular Effects of Silybin in Hypertensive Patients With High One-hour Post-load Plasma Glucose: a Single Arm Pilot Study Completed NCT03538327 Phase 4 Silybin
3 Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women. Completed NCT03921736 Phase 4 Perindopril;Hydrochlorothiazide;Estracomb TTS
4 Randomized, Multicenter, Double-blind, Placebo-controlled Efficacy and Safety Study of 8 mg PEG-uricase in Two Dose Regimens in Hyperuricemic Subjects With Symptomatic Gout Completed NCT00325195 Phase 3
5 Multicenter, Open Label Extension Study of 8 mg PEG-uricase in Subjects Who Completed Protocols C0405 or C0406 for Symptomatic Gout Completed NCT01356498 Phase 3
6 A Phase II Multidose Study of Intravenous PEG-uricase in Patients With Refractory Gout Completed NCT00111657 Phase 2
7 An Open Label Phase II Multiple Dose Safety, Pharmacokinetic and Pharmacodynamics Study of SEL-212 Followed by Open Label Administration of SEL-037 in Subjects With Symptomatic Gout and Elevated Blood Uric Acid Completed NCT02959918 Phase 2 SEL-212;SEL-037;SVP-rapamycin (SEL-110)
8 ULTRA-T2D Study: Uric Acid Lowering Trial in Youth Onset T2D Recruiting NCT03899883 Phase 2 Pegloticase 8 MG/ML [Krystexxa]
9 A Study to Compare the Efficacy of SEL-212 to KRYSTEXXA® in Gout Patients Refractory to Conventional Therapy Active, not recruiting NCT03905512 Phase 2 SEL-212;SEL-037;SEL-110;KRYSTEXXA®
10 A Cohort Dose-Escalation Phase 1 Study of Intramuscular Injection of Uricase-PEG 20 Unknown status NCT01038947 Phase 1
11 A Cohort Dose-Escalation Phase 1 Study of Intravenous Infusion of Uricase-PEG 20 Unknown status NCT01021241 Phase 1
12 A Randomized, Double-blinded, Placebo-controlled, Single-dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SSS11 Administered Intravenously in Healthy Volunteers. Unknown status NCT03388515 Phase 1
13 An Open-Label, Sequential, Ascending Single-Dose Safety, Tolerability, Pharmacokinetic and Pharmacodynamics Study of an Intravenous Infusion of SEL-037 in Subjects With Elevated Blood Uric Acid Levels Completed NCT02464605 Phase 1
14 A Phase I Single Ascending Dose Safety, Pharmacokinetic and Pharmacodynamics Study of SEL-212 in Subjects With Elevated Blood Uric Acid Completed NCT02648269 Phase 1 SEL-110
15 The Relationship Between Uric Acid and Inflammatory Markers Completed NCT01323335 Phase 1 IV Uric Acid;IV Rasburicase
16 An Open Label, Single-dose, Dose-increasing Study to Assess the Safety, Tolerability, PK and Preliminary PD of PEGylated Recombinant Candida Urate Oxidase (SSS11) for Injection in Chinese Healthy Adult Volunteers Not yet recruiting NCT04047394 Phase 1 PEGylated recombinant candida urate oxidase
17 Association of Maternal Uric Acid With Maternal Condition and Fetal Outcome in Pregnant Women With Hypertension Unknown status NCT01523327
18 Differential Effects of Uric Acid and Xanthine Oxidoreductase on Endothelial Function and Oxydative Stress Completed NCT03395977 Placebos;Febuxostat;Rasburicase
19 Paediatric Obesity and Cardiovascular Dysfunction: Searching for Early Markers of Damage Active, not recruiting NCT03169257

Search NIH Clinical Center for Urate Oxidase, Pseudogene

Genetic Tests for Urate Oxidase, Pseudogene

Anatomical Context for Urate Oxidase, Pseudogene

MalaCards organs/tissues related to Urate Oxidase, Pseudogene:

40
Liver, Kidney, Endothelial, Testes, Heart, Brain, Retina

Publications for Urate Oxidase, Pseudogene

Articles related to Urate Oxidase, Pseudogene:

(showing 1050, show less)
# Title Authors PMID Year
1
Evolutionary history and metabolic insights of ancient mammalian uricases. 56 61
24550457 2014
2
Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. 61 56
8290593 1994
3
Structural analysis of the gene encoding rat uricase. 61 56
1783398 1991
4
Urate oxidase: primary structure and evolutionary implications. 61 56
2594778 1989
5
A human genomic sequence highly homologous to the 3'-untranslated region of rat uricase mRNA. 56 61
3178807 1988
6
Localization of the human urate oxidase gene (UOX) to 1p22. 56
1395718 1992
7
Human urate oxidase gene: cloning and partial sequence analysis reveal a stop codon within the fifth exon. 56
2403354 1990
8
Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase. 56
3344434 1988
9
HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. 56
3821905 1987
10
A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. 56
3029599 1987
11
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? 56
13937884 1962
12
Species and sex differences in the blood clearance and immunogenicity of PEGylated uricase: A comparative 26-week toxicity study in rats and monkeys. 61
31610209 2020
13
The role of uric acid in inflammasome-mediated kidney injury. 61
32452918 2020
14
Cardio-renal protective effect of the xanthine oxidase inhibitor febuxostat in the 5/6 nephrectomy model with hyperuricemia. 61
32518351 2020
15
Hyperuricemia Predisposes to the Onset of Diabetes via Promoting Pancreatic β-Cell Death in Uricase-Deficient Male Mice. 61
32312870 2020
16
Construction and expression of recombinant uricase‑expressing genetically engineered bacteria and its application in rat model of hyperuricemia. 61
32323736 2020
17
Perfecting a high hypoxanthine phosphoribosyltransferase activity-uricase KO mice to test the effects of purine- and non-purine-type xanthine dehydrogenase (XDH) inhibitors. 61
31971609 2020
18
The consequences of altered microbiota in immune-related chronic kidney disease. 61
32437554 2020
19
J-shaped relationship between serum uric acid levels and the risk of ischemic stroke in high-risk individuals: A hospital-based observational study. 61
32447150 2020
20
Multimodal Enzyme Delivery and Therapy Enabled by Cell Membrane-Coated Metal-Organic Framework Nanoparticles. 61
32352801 2020
21
De novo design of functional zwitterionic biomimetic material for immunomodulation. 61
32523997 2020
22
Associations of serum iron and ferritin with hyperuricemia and serum uric acid. 61
32458239 2020
23
High-Dose IV Administration of Rasburicase Suppresses Anti-rasburicase Antibodies, Depletes Rasburicase-Specific Lymphocytes, and Upregulates Treg Cells. 61
32462555 2020
24
Development of Uric Acid Biosensor Using Gold Nanoparticles and Graphene Oxide Functionalized Micro-Ball Fiber Sensor Probe. 61
31831430 2020
25
Structure-Based Immunogenicity Prediction of Uricase from Fungal (Aspergillus flavus), Bacterial (Bacillus subtillis) and Mammalian Sources Using Immunoinformatic Approach. 61
32221804 2020
26
A ''naked-eye'' colorimetric and ratiometric fluorescence probe for uric acid based on Ti3C2 MXene quantum dots. 61
32081178 2020
27
Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. 61
31996020 2020
28
Pharmacokinetics of Polyethylene Glycol-Modified Canine Uricase Following Single and Multiple Intravenous Injections in Cynomolgus Monkeys. 61
32162270 2020
29
A natural complex product Yaocha reduces uric acid level in a live zebrafish model. 61
32087362 2020
30
Potential of a sensitive uric acid biosensor fabricated using hydroxyapatite nanowire/reduced graphene oxide/gold nanoparticle. 61
31729094 2020
31
Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts. 61
31621967 2020
32
Electrochemical determination of uric acid in urine and serum with uricase/carbon nanotube /carboxymethylcellulose electrode. 61
31836385 2020
33
Uricase-deficient rat is generated with CRISPR/Cas9 technique. 61
32368418 2020
34
Metabolic Acidosis Alters Expression of Slc22 Transporters in Mouse Kidney. 61
32062662 2020
35
Arterial hypertension associated with hyperuricemia: features of heart damage. 61
32386373 2020
36
Hypouricemia: what the practicing rheumatologist should know about this condition. 61
31650389 2020
37
Brushing the surface: cascade reactions between immobilized nanoreactors. 61
31859312 2020
38
Development of ImmTOR Tolerogenic Nanoparticles for the Mitigation of Anti-drug Antibodies. 61
32508839 2020
39
Comparison of Two Corticosteroid Pre-Infusion Regimens for Pegloticase in the United States: A Retrospective Analysis in Community Rheumatology Practices. 61
31673974 2019
40
Severe Hypouricemia Impairs Endothelium-Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo-Controlled, and Crossover Study. 61
31752638 2019
41
Enhanced Performance of Reagent-Less Carbon Nanodots Based Enzyme Electrochemical Biosensors. 61
31861148 2019
42
A ratiometric fluorescent probe for detection of uric acid based on the gold nanoclusters-quantum dots nanohybrid. 61
31176998 2019
43
A dual-signal colorimetric and ratiometric fluorescent nanoprobe for enzymatic determination of uric acid by using silicon nanoparticles. 61
31705210 2019
44
Uricase-containing coacervate microdroplets as enzyme active membrane-free protocells for detoxification of uric acid in serum. 61
31675031 2019
45
Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy. 61
31253939 2019
46
The value of serum uric acid levels to differentiate causes of transient loss of consciousness. 61
31476728 2019
47
Application of cyclic voltammetry to analyse uric acid and reducing agents in commercial milks. 61
31151606 2019
48
Screening of single or combined administration of 9 probiotics to reduce ammonia emissions from laying hens. 61
30982063 2019
49
Fabrication of an efficient and sensitive colorimetric biosensor based on Uricase/ Th-MOF for uric acid sensing in biological samples. 61
31220726 2019
50
Mathematical modeling for bioprocess optimization of a protein drug, uricase, production by Aspergillus welwitschiae strain 1-4. 61
31506445 2019
51
Antioxidant capacities in various animal sera as measured with multiple free-radical scavenging method. 61
31272792 2019
52
Toxicity assessment of wearable wound sensor constituents on keratinocytes. 61
30928693 2019
53
Nanozymes: From New Concepts, Mechanisms, and Standards to Applications. 61
31276379 2019
54
Pegloticase Treatment Significantly Decreases Blood Pressure in Patients With Chronic Gout. 61
31079535 2019
55
Mouse models for human hyperuricaemia: a critical review. 61
31118497 2019
56
Serum Urate, Uricase, and Blood Pressure Control in Gout. 61
31079534 2019
57
Uricase grafted nanoconducting matrix based electrochemical biosensor for ultrafast uric acid detection in human serum samples. 61
30797811 2019
58
A nanocomposite prepared from copper(II) and nitrogen-doped graphene quantum dots with peroxidase mimicking properties for chemiluminescent determination of uric acid. 61
31161235 2019
59
Uricase and Horseradish Peroxidase Hybrid CaHPO₄ Nanoflower Integrated with Transcutaneous Patches for Treatment of Hyperuricemia. 61
30890227 2019
60
Statistical media optimization for the production of clinical uricase from Bacillus subtilis strain SP6. 61
31193400 2019
61
Urate-lowering therapy alleviates atherosclerosis inflammatory response factors and neointimal lesions in a mouse model of induced carotid atherosclerosis. 61
30690853 2019
62
Association between Serum Uric Acid Level with Presence and Severity of Coronary Artery Disease. 61
31311215 2019
63
Uric acid analogue as a possible xenobiotic marker of uric acid transporter Urat1 in rats. 61
30826184 2019
64
Uric acid therapy for vasculoprotection in acute ischemic stroke. 61
31334357 2019
65
Advanced Colorimetric Paper Sensors Using Color Focusing Effect Based on Asymmetric Flow of Fluid. 61
30950270 2019
66
Potential Dangers of Serum Urate-Lowering Therapy. 61
30611833 2019
67
Nonenzymatic Serum Antioxidant Capacity in IBD and Its Association with the Severity of Bowel Inflammation and Corticosteroids Treatment. 61
30986917 2019
68
Pharmacological urate-lowering approaches in chronic kidney disease. 61
30769179 2019
69
Production and Characterization of Recombinant Wild Type Uricase from Indonesian Coelacanth (L. menadoensis) and Improvement of Its Thermostability by In Silico Rational Design and Disulphide Bridges Engineering. 61
30871218 2019
70
An electrochemical biosensor based on novel butylamine capped CZTS nanoparticles immobilized by uricase for uric acid detection. 61
30597431 2019
71
Antioxidant properties of citric acid interfere with the uricase-based measurement of circulating uric acid. 61
30447534 2019
72
Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease. 61
29847340 2019
73
A highly selective and sensitive colorimetric detection of uric acid in human serum based on MoS2-catalyzed oxidation TMB. 61
30542813 2019
74
Zwitterionic Hydrogels Based on a Degradable Disulfide Carboxybetaine Cross-Linker. 61
30119608 2019
75
Electrochemical Detection for Uric Acid Based on β-Lactoglobulin-Functionalized Multiwall Carbon Nanotubes Synthesis with PtNPs Nanocomposite. 61
30634585 2019
76
Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia. 61
30951542 2019
77
Selection of High Producers From Combinatorial Libraries for the Production of Recombinant Proteins in Escherichia coli and Vibrio natriegens. 61
31637238 2019
78
U-Shaped Association Between Serum Uric Acid Levels and Cognitive Functions in Patients with Type 2 Diabetes: A Cross-Sectional Study. 61
30958355 2019
79
Review of the Literature Examining the Association of Serum Uric Acid with Osteoporosis and Mechanistic Insights into Its Effect on Bone Metabolism. 61
30387405 2019
80
A Chromatin-Mimetic Nanomedicine for Therapeutic Tolerance Induction. 61
30412375 2018
81
A Case Report of Immunosuppressant Medication‒Associated Polyarticular Tophaceous Gout Successfully Treated Using the Polyethylene Glycol‒Conjugated Uricase Enzyme Pegloticase. 61
30577324 2018
82
Hypouricemic and Antioxidant Effects of Soy Vinegar Extracts in Hyperuricemic Mice. 61
30132721 2018
83
Tophus resolution in patients with chronic refractory gout who have persistent urate-lowering responses to pegloticase. 61
30594229 2018
84
Investigation on uric acid biosensor model for enzyme layer thickness for the application of arthritis disease diagnosis. 61
29713461 2018
85
Enzymatic determination of uric acid using water-soluble CuInS/ZnS quantum dots as a fluorescent probe. 61
30291453 2018
86
Comparative genomics of the Erwinia and Enterobacter olive fly endosymbionts. 61
30374192 2018
87
Adaptive effect of sericin on hepatic mitochondrial conformation through its regulation of apoptosis, autophagy and energy maintenance: a proteomics approach. 61
30297713 2018
88
Nanoscale Enzymatic Compartments in Tandem Support Cascade Reactions in Vitro. 61
30180548 2018
89
[Recent advances in gout: pathogenesis, diagnosis, comorbidities, treatment]. 61
30277413 2018
90
Expert opinion on emerging urate-lowering therapies. 61
30244605 2018
91
Evaluation of two sterically directed attachments of biomolecules on a coaxial nanofibre membrane to improve the development of optical biosensors. 61
29853069 2018
92
Efficient purification of a recombinant tag-free thermostable Kluyveromyces marxianus uricase by pH-induced self-cleavage of intein and expression in Escherichia coli. 61
30221113 2018
93
Uricase-free on-demand colorimetric biosensing of uric acid enabled by integrated CoP nanosheet arrays as a monolithic peroxidase mimic. 61
29681277 2018
94
Emergent nanotherapies in microcrystal-induced arthritis. 61
29890413 2018
95
Reduced graphene oxide-ZnO nanocomposite based electrochemical sensor for sensitive and selective monitoring of 8-hydroxy-2'-deoxyguanosine. 61
29759240 2018
96
Different Catabolism Pathways Triggered by Various Methylxanthines in Caffeine-Tolerant Bacterium Pseudomonas putida CT25 Isolated from Tea Garden Soil. 61
29926702 2018
97
Spatial Confined Synergistic Enzymes with Enhanced Uricolytic Performance and Reduced Toxicity for Effective Gout Treatment. 61
30035856 2018
98
A multifunctional material based on co-electrospinning for developing biosensors with optical oxygen transduction. 61
29530253 2018
99
Synovial fluid uric acid level aids diagnosis of gout. 61
29930806 2018
100
Ultrasound assisted process intensification of uricase and alkaline protease enzyme co-production in Bacillus licheniformis. 61
29705310 2018
101
Polypeptides with High Zwitterion Density for Safe and Effective Therapeutics. 61
29707870 2018
102
Dextrin-uricase conjugate: Preparation, characterization, and enzymatic properties. 61
29292142 2018
103
Investigational drugs for hyperuricemia, an update on recent developments. 61
29718730 2018
104
Zwitterionic Nanocages Overcome the Efficacy Loss of Biologic Drugs. 61
29457278 2018
105
Sensitive colorimetric assay for uric acid and glucose detection based on multilayer-modified paper with smartphone as signal readout. 61
29455281 2018
106
Association between serum uric acid concentrations and grip strength: Is there effect modification by age? 61
28139280 2018
107
Self-Catalyzing Chemiluminescence of Luminol-Diazonium Ion and Its Application for Catalyst-Free Hydrogen Peroxide Detection and Rat Arthritis Imaging. 61
29285924 2018
108
Earliest evidence of caries lesion in hominids reveal sugar-rich diet for a Middle Miocene dryopithecine from Europe. 61
30161214 2018
109
Evaluation of ADA activity as a potential marker of disease severity in psoriasis patients. 61
30234006 2018
110
Preparation, Characterization, and Application of Enzyme Nanoparticles. 61
30244789 2018
111
Impact of pegloticase on patient outcomes in refractory gout: current perspectives. 61
30425593 2018
112
CeO2-x/C/rGO nanocomposites derived from Ce-MOF and graphene oxide as a robust platform for highly sensitive uric acid detection. 61
29319098 2018
113
Serum Uric Acid as an Independent Risk Factor for the Presence and Severity of Early-Onset Coronary Artery Disease: A Case-Control Study. 61
30425752 2018
114
Hypertension as Determinant of Hyperuricemia: A Case Control Study from the Sub-Himalayan Region in North India. 61
30341839 2018
115
Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders. 61
28729031 2018
116
Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate. 61
30391956 2018
117
Optimization of novel and greener approach for the coproduction of uricase and alkaline protease in Bacillus licheniformis by Box-Behnken model. 61
28976246 2018
118
Uricase based fluorometric determination of uric acid based on the use of graphene quantum dot@silver core-shell nanocomposites. 61
29594655 2017
119
Uric acid contributes greatly to hepatic antioxidant capacity besides protein. 61
28937257 2017
120
Bioengineered robust hybrid hydrogels enrich the stability and efficacy of biological drugs. 61
28412223 2017
121
Pegloticase in gout treatment - safety issues, latest evidence and clinical considerations. 61
29204266 2017
122
Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China. 61
29275349 2017
123
The association between serum uric acid and blood pressure in different age groups in a healthy Chinese cohort. 61
29390287 2017
124
A facile strategy for enzyme immobilization with highly stable hierarchically porous metal-organic frameworks. 61
29112218 2017
125
Designing a mutant Candida uricase with improved polymerization state and enzymatic activity. 61
29161434 2017
126
Data for high-throughput estimation of specific activities of enzyme/mutants in cell lysates through immunoturbidimetric assay of proteins. 61
28795101 2017
127
Nanomolar Level Detection of Uric Acid in Blood Serum and Pest-Infested Grain Samples by an Amphiphilic Probe. 61
28795801 2017
128
Significance of Serum Uric Acid in Pregnancy Induced Hypertension. 61
28987249 2017
129
Novel lipidic and bienzymatic nanosomes for efficient delivery and enhanced bioactivity of catalase. 61
28888973 2017
130
High-throughput estimation of specific activities of enzyme/mutants in cell lysates through immunoturbidimetric assay of proteins. 61
28526525 2017
131
Allantoin contributes to the stress response in cadmium-treated Arabidopsis roots. 61
28858669 2017
132
Acute effects of thermally processed pili (Canarium ovatum, Engl.) pomace drink on plasma antioxidant and polyphenol status in humans. 61
29062808 2017
133
Low serum uric acid levels in chronic insomnia patients: A case-control study. 61
28801272 2017
134
Uric acid in plants and microorganisms: Biological applications and genetics - A review. 61
28748114 2017
135
A rapid and high-throughput method for the determination of serum uric acid based on microarray technology and nanomaterial. 61
27862937 2017
136
Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis). 61
28302963 2017
137
Catalase increases ethanol oxidation through the purine catabolism in rat liver. 61
28527616 2017
138
Electrochromic Sensor for Multiplex Detection of Metabolites Enabled by Closed Bipolar Electrode Coupling. 61
28750540 2017
139
Evaluating the urate-lowering effects of different microbial fermented extracts in hyperuricemic models accompanied with a safety study. 61
28911646 2017
140
Recombinant production of Aspergillus Flavus uricase and investigation of its thermal stability in the presence of raffinose and lactose. 61
28667645 2017
141
Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid. 61
28890842 2017
142
Erratum: Uricase alkaline enzymosomes with enhanced stabilities and anti-hyperuricemia effects induced by favorable microenvironmental changes. 61
28664903 2017
143
Gold nanoclusters as switch-off fluorescent probe for detection of uric acid based on the inner filter effect of hydrogen peroxide-mediated enlargement of gold nanoparticles. 61
28130993 2017
144
Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes. 61
28507007 2017
145
Biosensing platform for the detection of uric acid based on graphene quantum dots and G-quadruplex/hemin DNAzyme. 61
28366217 2017
146
Physiological concentrations of soluble uric acid are chondroprotective and anti-inflammatory. 61
28539647 2017
147
Study of ZnS Nanostructures Based Electrochemical and Photoelectrochemical Biosensors for Uric Acid Detection. 61
28555028 2017
148
Surface plasmon resonance biosensor for enzymatic detection of small analytes. 61
28287081 2017
149
Time to target uric acid to retard CKD progression. 61
27339448 2017
150
Solution Process Synthesis of High Aspect Ratio ZnO Nanorods on Electrode Surface for Sensitive Electrochemical Detection of Uric Acid. 61
28418039 2017
151
Impact of Mutations on the Higher Order Structure and Activity of a Recombinant Uricase. 61
28063825 2017
152
Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia. 61
28511370 2017
153
A Practical System for High-Throughput Screening of Mutants of Bacillus fastidiosus Uricase. 61
27614625 2017
154
Effect of surfactants and inducers on increased uricase production under submerged fermentations by Bacillus cereus. 61
27071031 2017
155
Oral uricase eliminates blood uric acid in the hyperuricemic pig model. 61
28594873 2017
156
[The phylogenetic theory of general pathology. The development of seven biological functions, seven specific ones and etiological factors of metabolic epidemics, millions years' common pathogenesis and basics of prevention.] 61
30802390 2017
157
Size-selective QD@MOF core-shell nanocomposites for the highly sensitive monitoring of oxidase activities. 61
27573301 2017
158
Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats. 61
28337250 2017
159
Upconversion ratiometric fluorescence and colorimetric dual-readout assay for uric acid. 61
27471157 2016
160
Allantoin Increases Cadmium Tolerance in Arabidopsis via Activation of Antioxidant Mechanisms. 61
27742885 2016
161
Rapid and highly-sensitive uric acid sensing based on enzymatic catalysis-induced upconversion inner filter effect. 61
27341137 2016
162
Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury. 61
27906636 2016
163
Urinary excretion of uric acid, allantoin, and 8-OH-Deoxyguanosine in uricase-knockout mice. 61
27906613 2016
164
Angiogenic factors are associated with multiple sclerosis. 61
27887749 2016
165
Utilizing intein-mediated protein cleaving for purification of uricase, a multimeric enzyme. 61
27702489 2016
166
Modification with polysialic acid-PEG copolymer as a new method for improving the therapeutic efficacy of proteins. 61
26829568 2016
167
Uric Acid Induces Cognitive Dysfunction through Hippocampal Inflammation in Rodents and Humans. 61
27798180 2016
168
Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles. 61
27479756 2016
169
Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout. 61
27352852 2016
170
Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism. 61
27465529 2016
171
Electrochemical detection of uric acid via uricase-immobilized graphene oxide. 61
27402177 2016
172
A Numerical Approach for Kinetic Analysis of the Nonexponential Thermoinactivation Process of Uricase. 61
27480193 2016
173
Nanocapsule assemblies as effective enzyme delivery systems against hyperuricemia. 61
27013130 2016
174
High fluorescence S, N co-doped carbon dots as an ultra-sensitive fluorescent probe for the determination of uric acid. 61
27216657 2016
175
Extracorporeal delivery of a therapeutic enzyme. 61
27477538 2016
176
Sodium butyrate mitigates in vitro ammonia generation in cecal content of laying hens. 61
27154844 2016
177
Iterative Outlier Removal: A Method for Identifying Outliers in Laboratory Recalibration Studies. 61
27197675 2016
178
Regulation of uric acid metabolism and excretion. 61
26316329 2016
179
Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization. 61
26509876 2016
180
Label-free and selective sensing of uric acid with gold nanoclusters as optical probe. 61
26992526 2016
181
Development of Therapeutic Chimeric Uricase by Exon Replacement/Restoration and Site-Directed Mutagenesis. 61
27213357 2016
182
Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone. 61
26907620 2016
183
Quantitative determination of uric acid using CdTe nanoparticles as fluorescence probes. 61
26433069 2016
184
Uric Acid and Coronary Artery Disease, Two Sides of a Single Coin: A Determinant of Antioxidant System or a Factor in Metabolic Syndrome. 61
27042498 2016
185
Uricase alkaline enzymosomes with enhanced stabilities and anti-hyperuricemia effects induced by favorable microenvironmental changes. 61
26823332 2016
186
A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties. 61
28002433 2016
187
DNA shuffling of uricase gene leads to a more "human like" chimeric uricase with increased uricolytic activity. 61
26526169 2016
188
Economic analysis of uricase production under uncertainty: Contrast of chromatographic purification and aqueous two-phase extraction (with and without PEG recycle). 61
26561271 2016
189
The Effect of the Mediterranean Diet on Serum Total Antioxidant Capacity in Obese Patients: A Randomized Controlled Trial. 61
25989426 2016
190
An analytical comparison between point-of-care uric acid testing meters. 61
26689648 2016
191
Fungal Community Associated with Dactylopius (Hemiptera: Coccoidea: Dactylopiidae) and Its Role in Uric Acid Metabolism. 61
27446001 2016
192
Horseradish peroxidase-catalyzed polymerization of L-DOPA for mono-/bi-enzyme immobilization and amperometric biosensing of H2O2 and uric acid. 61
26717822 2016
193
Uricosuric agents decrease the plasma urate level in rats by concomitant treatment with topiroxostat, a novel xanthine oxidoreductase inhibitor. 61
26589240 2016
194
Melamine Nephrotoxicity is Mediated by Hyperuricemia. 61
26777910 2015
195
Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics. 61
26276541 2015
196
Low Serum Levels of Uric Acid are Associated With Development of Poststroke Depression. 61
26559256 2015
197
Compound Tufuling Granules ([characters: see text]) regulate glucose transporter 9 expression in kidney to influence serum uric acid level in hyperuricemia mice. 61
25864117 2015
198
Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice. 61
26100496 2015
199
Crystal structure of Bacillus fastidious uricase reveals an unexpected folding of the C-terminus residues crucial for thermostability under physiological conditions. 61
25786739 2015
200
Purification and characterization of an extracellular uricase from a new isolate of Sphingobacterium thalpophilum (VITPCB5). 61
26145833 2015
201
[The Pharmacokinetics and Pharmacodynamics of Intravenous Uricase Multivesicular Liposomes]. 61
26619536 2015
202
Nanosomal Microassemblies for Highly Efficient and Safe Delivery of Therapeutic Enzymes. 61
26325262 2015
203
Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity. 61
26371311 2015
204
Uric acid as a modulator of glucose and lipid metabolism. 61
26133655 2015
205
Relationship of serum uric acid, serum creatinine and serum cystatin C with maternal and fetal outcomes in rural Indian pregnant women. 61
26583159 2015
206
The Chronic Kidney Disease - Colonic Axis. 61
25855516 2015
207
The Urinary Uric Acid/Creatinine Ratio is An Adjuvant Marker for Perinatal Asphyxia. 61
26998526 2015
208
[The Association Between Serum Uric Acid and Creatinine in Patients with Hypothyroidism]. 61
26619549 2015
209
Urate crystal degradation for treatment of gout: a nanoparticulate combination therapy approach. 61
25787730 2015
210
Cloning, Expression, and Purification of Recombinant Uricase Enzyme from Pseudomonas aeruginosa Ps43 Using Escherichia coli. 61
25588559 2015
211
A simple and sensitive fluorescence based biosensor for the determination of uric acid using H2O2-sensitive quantum dots/dual enzymes. 61
25113659 2015
212
Pharmacokinetics and pharmacodynamics of pegloticase in patients with end-stage renal failure receiving hemodialysis. 61
25816806 2015
213
No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse. 61
25565311 2015
214
Immobilization of Enzymes by Electrochemical and Chemical Oxidative Polymerization of L-DOPA to Fabricate Amperometric Biosensors and Biofuel Cells. 61
25938891 2015
215
Electrochemical performance and detection of 8-Hydroxy-2'-deoxyguanosine at single-stranded DNA functionalized graphene modified glassy carbon electrode. 61
25128367 2015
216
A novel third generation uric acid biosensor using uricase electro-activated with ferrocene on a Nafion coated glassy carbon electrode. 61
25461755 2015
217
Purification, characterization and in vitro application of a thermostable oxidant- and SDS-stable uricase from a newly isolated Bacillus firmus DWD-33. 61
25742044 2015
218
Amperometric uric acid biosensor based on poly(vinylferrocene)-gelatin-carboxylated multiwalled carbon nanotube modified glassy carbon electrode. 61
25618698 2015
219
[Preparation and characterization of uricase in uricase-catalase liposomes prepared using borate buffer]. 61
25736127 2015
220
Characterization of a Thermostable Uricase Isolated from Bacillus firmus DWD-33 and its Application for Uric Acid Quantification in Human Serum. 61
25981580 2015
221
Enhancement of a novel extracellular uricase production by media optimization and partial purification by aqueous three-phase system. 61
25674929 2015
222
A cytosolic thioredoxin acts as a molecular chaperone for peroxisome matrix proteins as well as antioxidant in peroxisome. 61
26013260 2015
223
Hyperuricemia, urate deposition and the association with hypertension. 61
26414732 2015
224
[Hyperuricemia and cardiovascular diseases: from phylogenesys to patogenetic mechanisms]. 61
26005870 2015
225
Optimization of pH values to formulate the bireagent kit for serum uric acid assay. 61
24673428 2015
226
Engineering Human Urate Oxidase: Towards Reactivating It as an Important Therapeutic Enzyme. 61
26343133 2015
227
[Anti-hyperuricemia effect and mechanism of polydatin in mice]. 61
25920206 2014
228
Poly(brilliant green) and poly(thionine) modified carbon nanotube coated carbon film electrodes for glucose and uric acid biosensors. 61
25159399 2014
229
Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase. 61
25314114 2014
230
Low circulating insulin-like growth factor-1 levels are associated with high serum uric acid in nondiabetic adult subjects. 61
25149895 2014
231
Infusion-related reactions with pegloticase, a recombinant uricase for the treatment of chronic gout refractory to conventional therapy. 61
25417679 2014
232
Isolation of a novel uric-acid-degrading microbe Comamonas sp. BT UA and rapid biosensing of uric acid from extracted uricase enzyme. 61
25431410 2014
233
Pharmacodynamic analysis of intravenous recombinant urate oxidase using an indirect pharmacological response model in healthy subjects. 61
25283504 2014
234
Comparison of modification of a bacterial uricase with N-hydroxysuccinimide esters of succinate and carbonate of monomethoxyl poly(ethylene glycol). 61
24512141 2014
235
Enhancing performance of uricase using multiwalled carbon nanotube doped polyaniline. 61
24928549 2014
236
Construction of an uricase nanoparticles modified au electrode for amperometric determination of uric acid. 61
25141984 2014
237
Characterization of purine catabolic pathway genes in coelacanths. 61
23733620 2014
238
Reagentless uric acid biosensor based on Ni microdiscs-loaded NiO thin film matrix. 61
25046556 2014
239
Confined multiple enzymatic (cascade) reactions within poly(dopamine)-based capsosomes. 61
24968314 2014
240
Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids. 61
24755741 2014
241
Consumption of strawberries on a daily basis increases the non-urate 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity of fasting plasma in healthy subjects. 61
25120279 2014
242
A general strategy to prepare homogeneous and reagentless GO/lucigenin&enzyme biosensors for detection of small biomolecules. 61
24549137 2014
243
Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. 61
24652948 2014
244
Pegloticase. An excessively dangerous and inadequately evaluated hypouricaemic drug. 61
25162087 2014
245
Comparison of two plasma urate assays in patients receiving vitamin C supplementation. 61
24798153 2014
246
An amperometric uric acid biosensor based on chitosan-carbon nanotubes electrospun nanofiber on silver nanoparticles. 61
24718436 2014
247
Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. 61
24663677 2014
248
Inducing electrocatalytic functionality in ZnO thin film by N doping to realize a third generation uric acid biosensor. 61
24362079 2014
249
Very fast electrophoretic determination of creatinine and uric acid in human urine using a combination of two capillaries with different internal diameters. 61
24114779 2014
250
Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients. 61
24602182 2014
251
Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout. 61
24588936 2014
252
Effect of processing parameters for electrocatalytic properties of SnO(2) thin film matrix for uric acid biosensor. 61
24396852 2014
253
Glassy carbon electrodes sequentially modified by cysteamine-capped gold nanoparticles and poly(amidoamine) dendrimers generation 4.5 for detecting uric acid in human serum without ascorbic acid interference. 61
24491759 2014
254
Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease. 61
23584883 2014
255
Real-time in vivo uric acid biosensor system for biophysical monitoring of birds. 61
24326318 2014
256
Determination of uric acid level by polyaniline and poly (allylamine): Based biosensor. 61
24696812 2014
257
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD. 61
24643131 2014
258
Activity and stability of uricase from Lactobacillus plantarum immobilizated on natural zeolite for uric acid biosensor. 61
24783814 2014
259
Covalent immobilization of uricase inside a plastic vial for uric acid determination in serum and urine. 61
24717661 2014
260
Isolation, screening and production studies of uricase producing bacteria from poultry sources. 61
24279683 2014
261
Preparing a new biosensor for hypoxanthine determination by immobilization of xanthine oxidase and uricase in polypyrrole-polyvinyl sulphonate film. 61
23305069 2013
262
Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP). 61
23665398 2013
263
Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice. 61
23804456 2013
264
Nitrogen-doped zinc oxide thin films biosensor for determination of uric acid. 61
23730688 2013
265
New developments in gout. 61
23466959 2013
266
Enzyme-entrapped mesoporous silica for treatment of uric acid disorders. 61
23802423 2013
267
A novel zwitterionic copolymer with a short poly(methyl acrylic acid) block for improving both conjugation and separation efficiency of a protein without losing its bioactivity. 61
32261048 2013
268
Disposable biosensor based on cathodic electrochemiluminescence of tris(2,2-bipyridine)ruthenium(II) for uric acid determination. 61
23498698 2013
269
Comparison of activity indexes for recognizing enzyme mutants of higher activity with uricase as model. 61
23594729 2013
270
Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology. 61
23401356 2013
271
Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. 61
22648289 2013
272
Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. 61
23303409 2013
273
Novel drug discovery strategies for gout. 61
23231400 2013
274
Enzyme-modified indium tin oxide microelectrode array-based electrochemical uric acid biosensor. 61
29470786 2013
275
Classification of difference between inhibition constants of an inhibitor to facilitate identifying the inhibition type. 61
22224402 2013
276
New therapies for gout. 61
23327525 2013
277
Associations of serum uric acid and SLC2A9 variant with depressive and anxiety disorders: a population-based study. 61
24204615 2013
278
Oral findings in end-stage renal disease. 61
24566019 2013
279
Is there association between uric acid and inflammation in hemodialysis patients? 61
23394103 2013
280
PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation. 61
23215688 2013
281
Thermal inactivation of uricase (urate oxidase): mechanism and effects of additives. 61
23237426 2013
282
Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents. 61
22931049 2012
283
Anti-inflammatory and immunomodulatory effects of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats. 61
22910180 2012
284
Protection of dopaminergic cells by urate requires its accumulation in astrocytes. 61
22671773 2012
285
CuO thin film based uric acid biosensor with enhanced response characteristics. 61
22647533 2012
286
Development of a sandwich format, amperometric screen-printed uric acid biosensor for urine analysis. 61
22705172 2012
287
Uricase from Bacillus fastidious loaded in alkaline enzymosomes: enhanced biochemical and pharmacological characteristics in hypouricemic rats. 61
22705639 2012
288
Pegloticase and the patient with treatment-failure gout. 61
23121270 2012
289
Gold nanoparticle-enzyme conjugates based FRET for highly sensitive determination of hydrogen peroxide, glucose and uric acid using tyramide reaction. 61
22745932 2012
290
Pegloticase for treating refractory chronic gout. 61
22844655 2012
291
Characterization, efficacy, pharmacokinetics, and biodistribution of 5kDa mPEG modified tetrameric canine uricase variant. 61
22503989 2012
292
Supplementation of poultry feeds with dietary zinc and other minerals and compounds to mitigate nitrogen emissions--a review. 61
22215283 2012
293
Comparative structural modeling and docking studies of uricase: possible implication in enzyme supplementation therapy for hyperuricemic disorders. 61
22537975 2012
294
Structure-based characterization of canine-human chimeric uricases and its evolutionary implications. 61
22481018 2012
295
Immbolization of uricase enzyme in Langmuir and Langmuir-Blodgett films of fatty acids: possible use as a uric acid sensor. 61
21875709 2012
296
[Gout: an overview of available urate lowering therapies]. 61
22655581 2012
297
Genome-wide analysis of the response of Dickeya dadantii 3937 to plant antimicrobial peptides. 61
22204647 2012
298
[The hyperiricosuria as an indicator of derangement of biologic functions of endoecology and adaptation, biologic reactions of excretion, inflammation and arterial tension]. 61
22768707 2012
299
Effect of lovastatin therapy and withdrawal on serum uric acid level in people with type 2 diabetic nephropathy. 61
22444196 2012
300
Up-to-date management of gout. 61
22301867 2012
301
Uricases as therapeutic agents to treat refractory gout: Current states and future directions. 61
22665944 2012
302
Pegloticase: a novel agent for treatment-refractory gout. 61
22395256 2012
303
Role of the methoxy group in immune responses to mPEG-protein conjugates. 61
22332808 2012
304
The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus. 61
22301198 2012
305
Recent advances in renal urate transport: characterization of candidate transporters indicated by genome-wide association studies. 61
22038265 2012
306
Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations. 61
23235493 2012
307
The influence of oxonate-induced hyperuricemia and allopurinol on behavioral reactions of random-bred mice. 61
23023694 2012
308
[New and emerging drugs for uric arthritis]. 61
23745467 2012
309
Multicenter uric acid biosensor based on tetrapod-shaped ZnO nanostructures. 61
22524012 2012
310
Critical appraisal of the role of pegloticase in the management of gout. 61
27790013 2012
311
Uric acid is more strongly associated with impaired glucose regulation in women than in men from the general population: the KORA F4-Study. 61
22615932 2012
312
Reproductive factors and serum uric acid levels in females from the general population: the KORA F4 study. 61
22427861 2012
313
Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury. 61
23226314 2012
314
Uricase-adsorbed carbon-felt reactor coupled with a peroxidase-modified carbon-felt-based H2O2 detector for highly sensitive amperometric flow determination of uric acid. 61
21906900 2012
315
Construction of amperometric uric acid biosensor based on uricase immobilized on PBNPs/cMWCNT/PANI/Au composite. 61
22020190 2012
316
Impact of large aggregated uricases and PEG diol on accelerated blood clearance of PEGylated canine uricase. 61
22745806 2012
317
A potentiometric indirect uric acid sensor based on ZnO nanoflakes and immobilized uricase. 61
22736977 2012
318
Improved biological properties and hypouricemic effects of uricase from Candida utilis loaded in novel alkaline enzymosomes. 61
22915844 2012
319
Highly sensitive and selective uric acid biosensor based on RF sputtered NiO thin film. 61
21996325 2011
320
Apical voltage-driven urate efflux transporter NPT4 in renal proximal tubule. 61
22132991 2011
321
Pegloticase: in treatment-refractory chronic gout. 61
22035516 2011
322
Association of serum uric acid with incident atrial fibrillation (from the Atherosclerosis Risk in Communities [ARIC] study). 61
21855838 2011
323
High-yield expression, purification, characterization, and structure determination of tag-free Candida utilis uricase. 61
21573940 2011
324
Egg yolk and serum antibody titers of broiler breeder hens immunized with uricase and or urease. 61
21933996 2011
325
Designing and engineering of a site-specific incorporation of a keto group in uricase. 61
21585711 2011
326
Long-term adherence to the Mediterranean diet reduces the prevalence of hyperuricaemia in elderly individuals, without known cardiovascular disease: the Ikaria study. 61
21724344 2011
327
Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations. 61
22000645 2011
328
[Current management of gout]. 61
22525631 2011
329
Disposable luminol copolymer-based biosensor for uric acid in urine. 61
21839206 2011
330
[New therapeutic options for gout]. 61
21684104 2011
331
Urate transporters: an evolving field. 61
22000646 2011
332
Biochemical measurement of neonatal hypoxia. 61
21897351 2011
333
Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials. 61
21846852 2011
334
Simple and rapid method for the determination of uric acid-independent antioxidant capacity. 61
21849933 2011
335
Difficult-to-treat gouty arthritis: a disease warranting better management. 61
21812506 2011
336
An amperometric uric acid biosensor based on multiwalled carbon nanotube-gold nanoparticle composite. 61
21315682 2011
337
Immobilization of uricase enzyme on self-assembled gold nanoparticles for application in uric acid biosensor. 61
21770094 2011
338
Polyoxazoline: chemistry, properties, and applications in drug delivery. 61
21452890 2011
339
Construction of uricase-overproducing strains of Hansenula polymorpha and its application as biological recognition element in microbial urate biosensor. 61
21612631 2011
340
Nano-sized platinum as a mimic of uricase catalyzing the oxidative degradation of uric acid. 61
21359394 2011
341
MarR homologs with urate-binding signature. 61
21432936 2011
342
Reversible immobilization of uricase on conductive polyaniline brushes grafted on polyacrylonitrile film. 61
20652599 2011
343
Production and partial characterization of uric acid degrading enzyme from new source Saccharopolyspora sp. PNR11. 61
21870646 2011
344
Conductimetric biosensor for the detection of uric Acid by immobilization uricase on nata de coco membrane-pt electrode. 61
21792276 2011
345
Gender-specific association of serum uric acid with metabolic syndrome and its components in juvenile obesity. 61
20961193 2011
346
MicroRNA expression patterns of the kidney in hyperuricemia mice treated with Xiezhuo Chubi Decoction. 61
21258895 2011
347
Estimation of serum uric acid in cases of hyperuricaemia and gout. 61
22335090 2011
348
Influence of physical activity intensity and aerobic fitness on the anthropometric index and serum uric acid concentration in people with obesity. 61
21963729 2011
349
Gout therapeutics: new drugs for an old disease. 61
20719377 2011
350
Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study. 61
21625475 2011
351
Adenosine A2A receptors and uric acid mediate protective effects of inosine against TNBS-induced colitis in rats. 61
20868668 2010
352
One-chip biosensor for simultaneous disease marker/calibration substance measurement in human urine by electrochemical surface plasmon resonance method. 61
20888212 2010
353
Fluorometric determination of uric acid in bovine milk. 61
20822564 2010
354
Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. 61
20810651 2010
355
A new practical system for evaluating the pharmacological properties of uricase as a potential drug for hyperuricemia. 61
21116779 2010
356
Uric acid and evolution. 61
20627967 2010
357
New advances in the treatment of gout: review of pegloticase. 61
21127695 2010
358
Urate is a ligand for the transcriptional regulator PecS. 61
20678501 2010
359
An amperomertic uric acid biosensor based on immobilization of uricase onto polyaniline-multiwalled carbon nanotube composite film. 61
20367113 2010
360
[Plasma antioxidant activity--a test for impaired biological functions of endoecology, exotrophy, and inflammation reactions]. 61
20799406 2010
361
Effect of plasma uric acid on pharmacokinetics of cyclosporine A in living-related renal transplant recipients and pharmacokinetic study in rats with experimental hyperuricaemia. 61
20831533 2010
362
Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese men. 61
20158446 2010
363
Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand. 61
20516624 2010
364
Uric acid does not affect the acetylcholine-induced relaxation of aorta from normotensive and deoxycorticosterone acetate-salt hypertensive rats. 61
20215410 2010
365
Identification of uricase as a potential target of plant thioredoxin: Implication in the regulation of nodule development. 61
20470756 2010
366
Serum uric acid in top-level alpine skiers over four consecutive competitive seasons. 61
20100473 2010
367
Association of cognitive function with serum uric acid level among Chinese nonagenarians and centenarians. 61
20080169 2010
368
Low-potential detection of endogenous and physiological uric acid at uricase-thionine-single-walled carbon nanotube modified electrodes. 61
20163156 2010
369
Biochemical and biopharmaceutical properties of PEGylated uricase. 61
19969053 2010
370
Construction of uric acid biosensor based on biomimetic titanate nanotubes. 61
20352728 2010
371
Effects of modification of amino groups with poly(ethylene glycol) on a recombinant uricase from Bacillus fastidiosus. 61
20530883 2010
372
Preparation and characterization of lipid vesicles containing uricase. 61
22747073 2010
373
Characterization, stabilization and activity of uricase loaded in lipid vesicles. 61
19782743 2010
374
Update on gout: new therapeutic strategies and options. 61
20046204 2010
375
Theodore E. Woodward award. The evolution of obesity: insights from the mid-Miocene. 61
20697570 2010
376
Exercise-induced changes in renal URAT1 activity and expression in rats. 61
20662700 2010
377
[Gout and comorbidities associated with hyperuricemia]. 61
21365938 2010
378
New and improved strategies for the treatment of gout. 61
21694941 2010
379
Recent insights into the pathogenesis of hyperuricaemia and gout. 61
19808794 2009
380
Reversible inactivation of an intracellular uricase from Bacillus fastidiosus via dissociation of homotetramer into homodimers in solutions of low ionic strength. 61
19734651 2009
381
Fabrication of dissolved O2 metric uric acid biosensor using uricase epoxy resin biocomposite membrane. 61
19591705 2009
382
Uric acid attenuates trophoblast invasion and integration into endothelial cell monolayers. 61
19535510 2009
383
Highly sensitive and selective uric acid biosensor based on direct electron transfer of hemoglobin-encapsulated chitosan-modified glassy carbon electrode. 61
19667479 2009
384
Urinary uric acid : creatinine ratios in healthy Turkish children. 61
19674364 2009
385
Electrochemical detection for paper-based microfluidics. 61
19485415 2009
386
Mechanism for attenuation of DNA binding by MarR family transcriptional regulators by small molecule ligands. 61
19501097 2009
387
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. 61
19218193 2009
388
A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout. 61
19296886 2009
389
Update on emerging urate-lowering therapies. 61
19339925 2009
390
Purine nucleotide catabolism in rat liver. Certain preliminary aspects of uricase reaction. 61
19333858 2009
391
Uric acid is a mediator of the Plasmodium falciparum-induced inflammatory response. 61
19381275 2009
392
Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society? 61
18649082 2009
393
An integration strategy to estimate the initial rates of enzyme reactions with much expanded linear ranges using uricases as models. 61
19046674 2009
394
The determination of uric acid in urine--forgotten problems rediscovered in an external quality assessment scheme. 61
20099570 2009
395
Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry. 61
19081307 2009
396
Strengthening intersubunit hydrogen bonds for enhanced stability of recombinant urate oxidase from Aspergillus flavus: molecular simulations and experimental validation. 61
19088989 2009
397
Fully reversible optical biosensors for uric acid using oxygen transduction. 61
18815025 2008
398
Serum uric acid levels correlate with plasma hydrogen peroxide and protein carbonyl levels in preeclampsia. 61
18802427 2008
399
Uric acid: bystander or culprit in hypertension and progressive renal disease? 61
18854744 2008
400
Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. 61
18701632 2008
401
An Amperometric Biosensor for Uric Acid Determination Prepared From Uricase Immobilized in Polyaniline-Polypyrrole Film. 61
27873826 2008
402
Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: results of a phase II randomized study. 61
18759308 2008
403
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. 61
18728266 2008
404
Uricase production by a recombinant Hansenula polymorpha strain harboring Candida utilis uricase gene. 61
18437374 2008
405
An electrochemiluminescent biosensor for uric acid based on the electrochemiluminescence of bis-[3,4,6-trichloro-2-(pentyloxycarbonyl)-phenyl] oxalate on an ITO electrode modified by an electropolymerized nickel phthalocyanine film. 61
18493682 2008
406
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. 61
18362170 2008
407
[Molecular mechanisms of urate transport in renal tubules: localization and function of urate transporters]. 61
18409511 2008
408
Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia. 61
18048425 2008
409
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. 61
18327257 2008
410
Pegloticase, a polyethylene glycol conjugate of uricase for the potential intravenous treatment of gout. 61
18393109 2008
411
[New antihyperuricemic medicine: febuxostat, Puricase, etc]. 61
18409528 2008
412
[How do we set the standard value of serum uric acid levels?]. 61
18409522 2008
413
Production of a thermostable uricase by a novel Bacillus thermocatenulatus strain. 61
17395458 2008
414
Refractory gout: what is it and what to do about it? 61
18349751 2008
415
Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice. 61
18306458 2008
416
The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease. 61
18331782 2008
417
Prevention of oxidative stress to the retina by pyruvate. A preliminary report. 61
18497529 2008
418
The impact of PEGylation on biological therapies. 61
18778113 2008
419
Developments in the scientific and clinical understanding of gout. 61
18947374 2008
420
PEG-uricase in the management of treatment-resistant gout and hyperuricemia. 61
17826865 2008
421
Uric acid determination using uricase and the autotransducer molecular absorption properties of peroxidase. 61
18190810 2008
422
Update on gout: pathophysiology and potential treatments. 61
18173979 2007
423
Assessment of outcome in clinical trials of gout--a review of current measures. 61
17650521 2007
424
Mercaptoethylpyrazine promoted electrochemistry of redox protein and amperometric biosensing of uric acid. 61
17719217 2007
425
Learning how and when to employ uricase as bridge therapy in refractory gout. 61
17924606 2007
426
Morphine enhances purine nucleotide catabolism in vivo and in vitro. 61
17640470 2007
427
Tumor lysis syndrome. 61
17525897 2007
428
Uricase and other novel agents for the management of patients with treatment-failure gout. 61
17531181 2007
429
Improved performance of polyaniline-uricase biosensor. 61
17560380 2007
430
Uric acid heralds ischemic tissue injury to mobilize endothelial progenitor cells. 61
17409313 2007
431
Dehydrogenase based reagentless biosensor for monitoring phenylketonuria. 61
17029777 2007
432
Emerging therapies in the long-term management of hyperuricaemia and gout. 61
17388867 2007
433
Therapeutic advances in gout. 61
17278926 2007
434
Development and analytical application of an uric acid biosensor using an uricase-immobilized eggshell membrane. 61
17023154 2007
435
Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout. 61
17328081 2007
436
Immobilization of uricase within polystyrene using polymaleimidostyrene as a stabilizer and its application to uric acid sensor. 61
17386751 2007
437
Hyperuricemia and gout: new insights into pathogenesis and treatment. 61
17922673 2007
438
Immobilization of uricase upon polypyrrole-ferrocenium film. 61
18097787 2007
439
The endogenous danger signal uric Acid augments contact hypersensitivity responses in mice. 61
17643063 2007
440
Enzymatic assay of allantoin in serum using allantoinase and allantoate amidohydrolase. 61
17081493 2006
441
Serum uric acid is a determinant of metabolic syndrome in a population-based study. 61
17027827 2006
442
An amperometric uric acid biosensor based on modified Ir-C electrode. 61
16908130 2006
443
Mouse transthyretin-related protein is a hydrolase which degrades 5-hydroxyisourate, the end product of the uricase reaction. 61
17085964 2006
444
High-level expression, purification, and characterization of non-tagged Aspergillus flavus urate oxidase in Escherichia coli. 61
16545578 2006
445
Rasburicase treatment in severe tophaceous gout: a novel therapeutic option. 61
16247589 2006
446
Characterization of a uricase from Bacillus fastidious A.T.C.C. 26904 and its application to serum uric acid assay by a patented kinetic uricase method. 61
16689679 2006
447
Uric acid recycling in the shield bug, Parastrachia japonensis (Hemiptera: Parastrachiidae), during diapause. 61
16797581 2006
448
Preliminary investigations on a new disposable potentiometric biosensor for uric acid. 61
16830944 2006
449
Advances in the management of gout and hyperuricaemia. 61
16882587 2006
450
Evaluation of a kinetic uricase method for serum uric acid assay by predicting background absorbance of uricase reaction solution with an integrated method. 61
16691645 2006
451
The crystal structure of the transcriptional regulator HucR from Deinococcus radiodurans reveals a repressor preconfigured for DNA binding. 61
16750221 2006
452
Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family. 61
16782815 2006
453
New developments in clinically relevant mechanisms and treatment of hyperuricemia. 61
16901081 2006
454
[The hydrogen peroxide paradox]. 61
16784144 2006
455
The occurrence and nature of electrochemical activity in milk from a herd of dairy cows. 61
16433970 2006
456
A clinical assessment of direct electrochemical urate measurements. 61
18970486 2006
457
ZnS quantum dots derived a reagentless uric acid biosensor. 61
18970471 2006
458
Newer therapeutic approaches: gout. 61
16504833 2006
459
Combined approach to the analysis of recombinant protein drugs using hollow-fiber flow field-flow fractionation, mass spectrometry, and chemiluminescence detection. 61
16478098 2006
460
[Gout]. 61
16463802 2006
461
Allopurinol/uricase and ibuprofen enhance engraftment of cardiomyocyte-enriched human embryonic stem cells and improve cardiac function following myocardial injury. 61
16337396 2006
462
Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase. 61
16356199 2006
463
An amperometric biosensor for uric acid determination prepared from uricase immobilized in polypyrrole film. 61
16809136 2006
464
[Role of uric acid in hypertension and in the progression of chronic renal disease]. 61
16521070 2006
465
Purification, and properties of a bovine uricase. 61
16712512 2006
466
Salivary cortisol-marker of stress response to different dental treatment. 61
17236287 2006
467
Purine catabolism in advanced carotid artery plaque. 61
17065109 2006
468
Gout in 2006: the perfect storm. 61
17121496 2006
469
Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics. 61
16820043 2006
470
Isolation of glyoxysomes from pumpkin cotyledons. 61
18228487 2006
471
Uric acid--a uremic toxin? 61
16361844 2006
472
Pathophysiology, clinical presentation and treatment of gout. 61
16956303 2006
473
Plasma antioxidant capacity among middle-aged men: the contribution of uric acid. 61
16714252 2006
474
[Multifactorial disorder: molecular and evolutionary insights of uric acid nephrolithiasis]. 61
16518303 2005
475
Hypouricemic effects of acacetin and 4,5-o-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats. 61
16327155 2005
476
Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. 61
16098976 2005
477
Nitrogen-responsive genes are differentially regulated in planta during Fusarium oxyspsorum f. sp. lycopersici infection. 61
20565671 2005
478
Negative cooperativity of uric acid binding to the transcriptional regulator HucR from Deinococcus radiodurans. 61
15967460 2005
479
Renal urate handling: clinical relevance of recent advances. 61
15919000 2005
480
Hyperuricemia induces endothelial dysfunction. 61
15840020 2005
481
An increase of uricogenesis in the Kuruma shrimp Marsupenaeus japonicus under nitrite stress. 61
15776415 2005
482
Serum uric acid levels and leukocyte nitric oxide production in multiple sclerosis patients outside relapses. 61
15792819 2005
483
[Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats]. 61
15738631 2005
484
Urate oxidase from Aspergillus flavus: new crystal-packing contacts in relation to the content of the active site. 61
15735331 2005
485
Uric acid, evolution and primitive cultures. 61
15660328 2005
486
Hemodynamics of hyperuricemia. 61
15660330 2005
487
Overview of hyperuricaemia and gout. 61
16375732 2005
488
Study of carbon nanotube modified biosensors for monitoring uric acid and total cholesterol in blood. 61
17282161 2005
489
The comparison of the estimation of enzyme kinetic parameters by fitting reaction curve to the integrated Michaelis-Menten rate equations of different predictor variables. 61
15656940 2005
490
Production of the carbonate radical anion during xanthine oxidase turnover in the presence of bicarbonate. 61
15448145 2004
491
HucR, a novel uric acid-responsive member of the MarR family of transcriptional regulators from Deinococcus radiodurans. 61
15448166 2004
492
Simultaneous determination of renal clinical analytes in serum using hydrolase- and oxidase-encapsulated optical array biosensors. 61
15464967 2004
493
EPR spin trapping of a radical intermediate in the urate oxidase reaction. 61
15571216 2004
494
[Physiology and biochemistry of uric acid]. 61
15493112 2004
495
Emergence of Talanin protein associated with human uric acid nephrolithiasis in the Hominidae lineage. 61
15363853 2004
496
In vivo and in vitro degradation of urea and uric acid by encapsulated genetically modified microorganisms. 61
15588404 2004
497
Exclusion of galectin 9 as a candidate gene for hyperuricosuria in the Dalmatian dog. 61
15265074 2004
498
Uric acid promotes tumor immune rejection. 61
15289304 2004
499
Detection of serum uric acid using the optical polymeric enzyme biochip system. 61
15142596 2004
500
Polyaniline-uricase biosensor prepared with template process. 61
15142597 2004
501
Volatiles production and attractiveness to the Mexican fruit fly of Enterobacter agglomerans isolated from apple maggot and Mexican fruit flies. 61
15503523 2004
502
Increase of uricogenesis in the kuruma shrimp Marsupenaeus japonicus reared under hyper-osmotic conditions. 61
15253873 2004
503
Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase. 61
15134605 2004
504
Ureide biosynthesis in legume nodules. 61
14977553 2004
505
Degradation of low molecular weight uremic solutes by oral delivery of encapsulated enzymes. 61
15171478 2004
506
Development of an HPLC method with electrochemical detection of femtomoles of 8-oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine in the presence of uric acid. 61
18969435 2004
507
Flow-injection assay of catalase activity. 61
15068290 2004
508
2,8-Dihydroxyadenine renal stones in a 41-year-old man. 61
15025810 2004
509
Modified colorimetric assay for uricase activity and a screen for mutant Bacillus subtilis uricase genes following StEP mutagenesis. 61
14728678 2004
510
Identification, cloning and expression of Pseudomonas aeruginosa Ps-x putative urate oxidase gene in Escherichia coli. 61
15790071 2004
511
Purification and characterization of extracellular Pseudomonas aeruginosa urate oxidase enzyme. 61
15330267 2004
512
Molecular cloning and expression of uricase gene from Arthrobacter globiformis in Escherichia coli and characterization of the gene product. 61
16233683 2004
513
Peroxynitrite delivery methods for toxicity studies. 61
14727917 2004
514
A reagent less fluorescent sol-gel biosensor for uric acid detection in biological fluids. 61
14596833 2003
515
Amperometric uric acid sensors based on polyelectrolyte multilayer films. 61
18969195 2003
516
Production of an egg yolk antibody specific to microbial uricase and its inhibitory effects on uricase activity. 61
14601732 2003
517
[Urate transporter and renal hypouricemia]. 61
14560659 2003
518
The case for uricase in gout. 61
12744813 2003
519
The epidemiology of hyperuricemia in children of Taiwan aborigines. 61
12672209 2003
520
Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid. 61
12562831 2003
521
The transthyretin-related protein family. 61
12542701 2003
522
Effect of minerals on activity of microbial uricase to reduce ammonia volatilization in poultry manure. 61
12619798 2003
523
Quantification of urinary urate with alkylamine glass-bound uricase and arylamine glass-bound peroxidase. 61
23105367 2003
524
Hyperuricemia causes glomerular hypertrophy in the rat. 61
12373074 2003
525
A role for uric acid in the progression of renal disease. 61
12444207 2002
526
[Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice]. 61
12776538 2002
527
Modified high amylose starch for immobilization of uricase for therapeutic application. 61
12452799 2002
528
Regulation of expression of the Rhizopus oryzae uricase and urease enzymes. 61
12619824 2002
529
Urate produced during hypoxia protects heart proteins from peroxynitrite-mediated protein nitration. 61
12398932 2002
530
A colorimetric 96-well microtiter plate assay for the determination of urate oxidase activity and its kinetic parameters. 61
12413448 2002
531
Microarray analysis of gene expression in rat hippocampus after chronic ethanol treatment. 61
12462420 2002
532
Emergency care: the tumor lysis syndrome. 61
14974215 2002
533
Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies. 61
12233890 2002
534
Chemiluminescence biosensor chip based on a microreactor using carrier air flow for determination of uric acid in human serum. 61
12375839 2002
535
Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. 61
12215479 2002
536
Modulation of gene and protein expression by carbon tetrachloride in the rat liver. 61
12217644 2002
537
A purification method of the diagnostic enzyme Bacillus uricase using magnetic beads and non-specific protease. 61
12182822 2002
538
Modification of a reactive cysteine explains differences between rasburicase and Uricozyme, a natural Aspergillus flavus uricase. 61
12149119 2002
539
Purine metabolizing capability of Enterobacter agglomerans affects volatiles production and attractiveness to Mexican fruit fly. 61
12371809 2002
540
Effect of short-term N(2) deficiency on expression of the ureide pathway in cowpea root nodules. 61
12114575 2002
541
Molecular identification of a renal urate anion exchanger that regulates blood urate levels. 61
12024214 2002
542
Urate oxidase from the rust Puccinia recondita is a heterotetramer with two different-sized monomers. 61
11910495 2002
543
Uric acid is a genuine metabolite of Penicillium cyclopium and stimulates the expression of alkaloid biosynthesis in this fungus. 61
11916664 2002
544
The analysis of uric acid in urine using microchip capillary electrophoresis with electrochemical detection. 61
11891710 2002
545
Host plant nodule parameters associated with nitrogen fixation efficiency in French bean (Phaseolus vulgaris L) cultivars. 61
12635706 2002
546
Chemiluminometric sensor for simultaneous determination of L-glutamate and L-lysine with immobilized oxidases in a flow injection system. 61
11922293 2002
547
Morphologic phenotyping with MR microscopy: the visible mouse. 61
11867802 2002
548
Bioconversion of poultry wastes. I--Factors influencing the assay and productivity of crude uricase by three uricolytic filamentous fungi. 61
12512254 2002
549
Bioconversion of poultry wastes I-factors influencing the assay and productivity of crude uricase by three uricolytic filamentous fungi. 61
11837392 2002
550
Temperature induced alterations in the liver of wall lizard (Hemidactylus frenatus): morphological and biochemical parameters. 61
12475563 2002
551
Estimation of allantoin flux using continuous infusion of [14C]allantoin: sensitivity to plasma loading with unlabelled allantoin. 61
11749678 2001
552
Expression of the urate transporter/channel is developmentally regulated in human kidneys. 61
11592946 2001
553
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. 61
11711505 2001
554
Flow-through chemiluminescence sensor using immobilized oxidases for the selective determination of L-glutamate in a flow-injection system. 61
11708095 2001
555
Immunological properties of uricase conjugated to neutral soluble polymers. 61
11459455 2001
556
Direct determination of uric acid in serum by a fluorometric-enzymatic method based on uricase. 61
18968307 2001
557
Functional analysis of 14 genes that constitute the purine catabolic pathway in Bacillus subtilis and evidence for a novel regulon controlled by the PucR transcription activator. 61
11344136 2001
558
Pathways for urea production during early life of an air-breathing teleost, the African catfish Clarias gariepinus Burchell. 61
11441057 2001
559
Voltammetric biosensors for the determination of formate and glucose-6-phosphate based on the measurement of dehydrogenase-generated NADH and NADPH. 61
11340000 2001
560
The cloning, genomic structure, localization, and expression of human deoxyribonuclease IIbeta. 61
11376952 2001
561
Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase. 61
11316859 2001
562
Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors. 61
11294382 2001
563
Hyperuricemia exacerbates chronic cyclosporine nephropathy. 61
11349724 2001
564
Purine nucleotide catabolism in rat liver: labelling of uric acid and allantoin after treatment with oxonic acid and allopurinol. 61
11228097 2001
565
Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. 61
11474184 2001
566
Potassium citrate administration ameliorates tubulointerstitial lesions in rats with uric acid nephropathy. 61
11200869 2001
567
[Cloning and expression of urate oxidase and its application in serum uric acid analysis]. 61
11330191 2001
568
Structural and expression analysis of uricase mRNA from Lotus japonicus. 61
11043477 2000
569
Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathy. 61
11126199 2000
570
Fully-automated spectrophotometric method for measurement of antioxidant activity of catalase. 61
11124337 2000
571
Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization. 61
11054555 2000
572
Evolutionary studies on uricases of fungal endosymbionts of aphids and planthoppers. 61
11029071 2000
573
Effect of tea and coffee consumption on serum uric acid levels by liquid-chromatographic and uricase methods. 61
10903352 2000
574
Xenopus allantoicase: molecular cloning, enzymatic activity and developmental expression. 61
10864446 2000
575
Interaction of hypoxanthine/xanthine oxidase with nitrergic relaxation in the porcine gastric fundus. 61
10807674 2000
576
Therapeutic proteins: a comparison of chemical and biological properties of uricase conjugated to linear or branched poly(ethylene glycol) and poly(N-acryloylmorpholine). 61
10966157 2000
577
Determination of urinary urate with alkylamine glass-bound uricase. 61
10983426 2000
578
Cloning, sequence analysis and expression in Escherichia coli of the gene encoding a uricase from the yeast-like symbiont of the brown planthopper, Nilaparvata lugens. 61
10696593 2000
579
Nonenzymatic elimination of ascorbic acid in clinical samples. 61
10693983 2000
580
Evolution of urate-degrading enzymes in animal peroxisomes. 61
11330038 2000
581
Expression of two uricase (Nodulin-35 genes in a non-ureide type legume, Medicago sativa. 61
10750714 2000
582
A biomimetic phospholipid/alkanethiolate bilayer immobilizing uricase and an electron mediator on an Au electrode for amperometric determination of uric acid. 61
10517148 1999
583
Degradation of overexpressed wild-type and mutant uricase proteins in cultured cells. 61
10449534 1999
584
Biopharmaceutical properties of uricase conjugated to neutral and amphiphilic polymers. 61
10411462 1999
585
'Pseudohypouricosuria' in alcaptonuria: homogentisic acid interference in the measurement of urinary uric acid with the uricase-peroxidase reaction. 61
10456213 1999
586
Nigrostriatal catecholamine metabolism in guinea pigs is altered by purine enzyme inhibition. 61
10442406 1999
587
Xanthine degradation and related enzyme activities in leaves and fruits of two coffea species differing in caffeine catabolism. 61
10552461 1999
588
Uricase-catalyzed oxidation of uric acid using an artificial electron acceptor and fabrication of amperometric uric acid sensors with use of a redox ladder polymer. 61
10361492 1999
589
Functional analysis and molecular modeling of a cloned urate transporter/channel. 61
10227848 1999
590
Discrete analysis of serum uric acid with immobilized uricase and peroxidase. 61
10392568 1999
591
[Biochemical efficacy of homeopathic and electronic preparations of D8 potassium cyanate]. 61
10213876 1999
592
A comparative study on the hypouricemic activity and potency in renal xanthine calculus formation of two xanthine oxidase/xanthine dehydrogenase inhibitors: TEI-6720 and allopurinol in rats. 61
10741381 1999
593
Interference of IgM paraproteins in the Olympus AU800 uric acid assay. 61
9812170 1998
594
Trimethylamine oxide and urea synthesis in rainbow smelt and some other northern fishes. 61
9754528 1998
595
Highly sensitive flow detection of uric acid based on an intermediate regeneration of uricase. 61
10071392 1998
596
Determination of uric acid in scalp hair for non-invasive evaluation of uricemic controls in hyperuricemia. 61
9586580 1998
597
The epidemiology study of hyperuricemia and gout in a community population of Huangpu District in Shanghai. 61
10374422 1998
598
Determination of 15N isotopic enrichment and concentrations of allantoin and uric acid in urine by gas chromatography/mass spectrometry. 61
9487687 1998
599
Characterization of the common bean uricase II and its expression in organs other than nodules. 61
9414545 1997
600
Enzymatic method for assaying uric acid in serum with a new tetrazolium salt produces water-soluble formazan dye. 61
9455611 1997
601
[Determination of uric acid in scalp hair for non-invasive estimation of uricemic control in hyperuricemia]. 61
9396346 1997
602
Two distinct uricase II (nodulin 35) genes are differentially expressed in soybean plants. 61
9245835 1997
603
Immobilization of uricase to gas diffusion carbon felt by electropolymerization of aniline and its application as an enzyme reactor for uric acid sensor. 61
18966880 1997
604
Reference values of common blood chemistry analytes in healthy population of Rawalpindi-Islamabad area. 61
9301167 1997
605
Quantification of urinary uric acid in the presence of thymol and thimerosal by high-performance liquid chromatography. 61
9129322 1997
606
Expression of a gene for uricase II (nodulin-35) in cotyledons of soybean plants. 61
9097481 1997
607
Gout is on the increase in New Zealand. 61
9059136 1997
608
Preparation of a monoclonal antibody against soybean nodule uricase (nod-35), and immunoblot analysis of the expression of nod-35 in tissues of various legumes. 61
9032970 1996
609
Cloning, sequence analysis, and expression in Escherichia coli of the gene encoding the Candida utilis urate oxidase (uricase). 61
8982864 1996
610
[Development of drug delivery systems for macromolecular drugs]. 61
8831257 1996
611
Poly(o-aminophenol)-modified bienzyme carbon paste electrode for the detection of uric acid. 61
18966549 1996
612
Peroxynitrite-mediated formation of free radicals in human plasma: EPR detection of ascorbyl, albumin-thiyl and uric acid-derived free radicals. 61
8615782 1996
613
Construction of catalase deficient Escherichia coli strains for the production of uricase. 61
8901098 1996
614
[Level of uric acid in aqueous and vitreous humor of man]. 61
9026580 1996
615
[Level of uric acid in aqueous humor of patients with cataract]. 61
9026581 1996
616
[Uric acid level in human aqueous and vitreous humor]. 61
9463115 1996
617
[Uric acid level in aqueous humor of patients with cataract]. 61
9463116 1996
618
Nucleotide sequence of the uricase gene from Bacillus sp. TB-90. 61
8907179 1996
619
Characterization of differing effects caused by homeopathically prepared and conventional dilutions using cytochrome P450 2E1 and other enzymes as detection systems. 61
9395660 1996
620
Hydrogen peroxide metabolism during peroxisome proliferation by fenofibrate. 61
8541349 1995
621
High cell density cultivation and high recombinant protein production of Escherichia coli strain expressing uricase. 61
8611749 1995
622
Transcription of the rat liver uricase-encoding gene is regulated via a cis-acting element responsive to cAMP. 61
8566790 1995
623
NO2 reactive absorption substrates in rat pulmonary surface lining fluids. 61
8529914 1995
624
Effect of chronic experimental renal insufficiency on urate metabolism. 61
8589304 1995
625
Use of azure-D2 for the measurement of uric acid in serum. 61
8611669 1995
626
Morphological and Molecular Characteristics of Host-Conditioned Ineffective Root Nodules in Cowpea. 61
12228592 1995
627
Reconstitution of hepatic uricase in planar lipid bilayer reveals a functional organic anion channel. 61
7473683 1995
628
Peroxyoxalate chemiluminescent assay for oxidase activities based on detecting enzymatically formed hydrogen peroxide. 61
7676861 1995
629
Purification and properties of uricase from Candida sp. and its application in uric acid analysis in serum. 61
7785878 1995
630
Biosensor based on chemiluminescence for serum uric acid determination. 61
8679934 1995
631
Expression pattern of uricase II gene during root nodule development in Phaseolus vulgaris. 61
7843336 1995
632
Separation and determination of liver uric acid and allantoin. 61
7704201 1995
633
Chromium toxicity in Neurospora crassa. 61
7798896 1994
634
Factitiously low urate recoveries in control sera with the Beckman Synchron Systems. 61
7809582 1994
635
Novel, reagentless, amperometric biosensor for uric acid based on a chemically modified screen-printed carbon electrode coated with cellulose acetate and uricase. 61
8067535 1994
636
Purification and properties of uricase from Candida sp. and its application in uric acid analysis in serum. 61
8203871 1994
637
A sensitive determination of uric acid in serum using uricase/catalase/formaldehyde dehydrogenase coupled with formate dehydrogenase. 61
8070073 1994
638
Isolation and immunolocalization of a rat renal cortical membrane urate transporter. 61
8120036 1994
639
Preparation of fibre-entrapped enzyme using cellulose acetate-titanium-iso-propoxide composite as gel matrix. 61
7764733 1994
640
Polymers for delivering peptides and proteins. 61
8160672 1994
641
[Spectrophotometric determination of uric acid in serum using a titanium (IV)-porphyrin complex]. 61
8133459 1994
642
Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation. 61
8124580 1994
643
Hypouricemic and uricosuric actions of AA-193 in a hyperuricemic rat model. 61
8289669 1994
644
Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. 61
8243554 1993
645
[The postnatal development of porcine purine catabolism and the effect of the environmental temperature on turnover]. 61
8237173 1993
646
Expression of antisense nodulin-35 RNA in Vigna aconitifolia transgenic root nodules retards peroxisome development and affects nitrogen availability to the plant. 61
8220465 1993
647
Genetic improvements of an industrial strain of Aspergillus flavus for urate oxidase production. 61
7763466 1993
648
High-level production of a peroxisomal enzyme: Aspergillus flavus uricase accumulates intracellularly and is active in Saccharomyces cerevisiae. 61
1452020 1992
649
Red blood cells as an antigen-delivery system. 61
1457052 1992
650
Identification of an amino acid residue involved in the substrate-binding site of rat liver uricase by site-directed mutagenesis. 61
1520291 1992
651
Effects of serum bilirubin on determination of uric acid by the uricase-peroxidase coupled reaction. 61
1320471 1992
652
Quantitative separation of uric acid and allantoin from rat liver tissue. 61
1627585 1992
653
Dissection of Nodule Development by Supplementation of Rhizobium leguminosarum biovar phaseoli Purine Auxotrophs with 4-Aminoimidazole-5-Carboxamide Riboside. 61
16668898 1992
654
Influence of triglycerides and urate on methods for determination of fructosamine. 61
1591869 1992
655
Cloning and expression in Escherichia coli of the gene encoding Aspergillus flavus urate oxidase. 61
1339455 1992
656
Evidence for malonyl-CoA-sensitive carnitine acyl-CoA transferase activity in sarcoplasmic reticulum of canine heart. 61
1625348 1992
657
Colostral antioxidants: separation and characterization of two activities in human colostrum. 61
1573513 1992
658
Adapting the uricase/peroxidase procedure for plasma urate to reduce interference due to haemolysis, icterus or lipaemia. 61
1536532 1992
659
Comparison of uricase-bound and uricase-loaded erythrocytes as bioreactors for uric acid degradation. 61
1295305 1992
660
Tissue distribution of 111In-labeled uricase conjugated with charged dextrans and polyethylene glycol. 61
1725532 1991
661
Use of the o-phenylenediamine fluorescence system in the enzymatic assay of serum uric acid. 61
1806295 1991
662
Uricase-like catalytic activity of ion-exchange resins modified with metalloporphyrins. 61
18965220 1991
663
Anomalously high concentrations of brain extracellular uric acid detected with chronically implanted probes: implications for in vivo sampling techniques. 61
2051164 1991
664
Oxygen regulation of uricase and sucrose synthase synthesis in soybean callus tissue is exerted at the mRNA level. 61
1830495 1991
665
Induction of biotransformation in the liver of Eel (Anguilla anguilla L.) by sublethal exposure to dinitro-o-cresol: an ultrastructural and biochemical study. 61
2065626 1991
666
Fructosamine Test-Plus, a modified fructosamine assay evaluated. 61
2015670 1991
667
Soybean Nodule-Specific Uricase (Nodulin-35) Is Expressed and Assembled into a Functional Tetrameric Holoenzyme in Escherichia coli. 61
16667995 1991
668
Effect of bilirubin on uricase-peroxidase coupled reactions. Implications for urate measurement in clinical samples and external quality assessment schemes. 61
2024944 1991
669
Structural analysis of the rat uricase gene and evidence that lysine 164 is involved in the substrate-binding site of the enzyme. 61
1789248 1991
670
Determination of urate in undiluted whole blood by enzyme electrode. 61
1910669 1991
671
Reperfusion-induced arrhythmias are not prevented by uric acid in the isolated rat heart. 61
1937149 1991
672
Two rabbit uricase mRNAs and their tissue-specific expression. 61
2269363 1990
673
Characterization of liver-specific expression of rat uricase using monoclonal antibodies and cloned cDNAs. 61
2248979 1990
674
Effect of oxygen pressure on synthesis and export of nitrogenous solutes by nodules of cowpea. 61
24197378 1990
675
Molecular characterization of the Drosophila melanogaster urate oxidase gene, an ecdysone-repressible gene expressed only in the malpighian tubules. 61
2118989 1990
676
Uric acid is a major antioxidant in human nasal airway secretions. 61
2217195 1990
677
An improved colorimetric assay for fructosamine. 61
2121089 1990
678
Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol. 61
1702692 1990
679
Organization of rat uricase chromosomal gene differs greatly from that of the corresponding plant gene. 61
2338140 1990
680
The effect of decreasing the concentration of urinary urate on the crystallization of calcium oxalate in undiluted human urine. 61
2329597 1990
681
An enzymatic assay for the colorimetric and fluorimetric determination of uric acid in sera. 61
2360868 1990
682
[Significance of blood uric acid determination. Review of the literature]. 61
2195627 1990
683
[Electron microscopic morphometric studies of the development of peroxisomes in healthy piglets during the first 4 weeks of life]. 61
2114713 1990
684
Purification of nodule-specific uricase from soybean by arginine-sepharose affinity chromatography. 61
2367346 1990
685
[Clinical laboratory application of HPLC]. 61
2308225 1990
686
Excretion of purine derivatives by ruminants: endogenous excretion, differences between cattle and sheep. 61
2317473 1990
687
[A new fructosamine test--as a routine parameter in the control of diabetes]. 61
2181784 1990
688
Purification of microbial uricase. 61
2625463 1989
689
Cloning of rabbit uricase cDNA reveals a conserved carboxy-terminal tripeptide in three species. 61
2719958 1989
690
An enzymic assay for uric acid in serum and urine compared with HPLC. 61
2708944 1989
691
Degradation of uric acid in fish liver peroxisomes. Intraperoxisomal localization of hepatic allantoicase and purification of its peroxisomal membrane-bound form. 61
2492531 1989
692
Nonenzymatic stopped-flow fluorimetric method for direct determination of uric acid in serum and urine. 61
2914366 1989
693
[Culture conditions for uricase formation of Candida utilis]. 61
2800538 1989
694
A radiochemical-high-performance liquid chromatographic assay for urate oxidase in human plasma. 61
2742121 1989
695
[A recommended method for determination of uric acid in serum]. 61
2782673 1989
696
Sequence analysis of rat liver uricase-cDNA and the possible presence of the homologous cDNA sequences in chicken embryo. 61
2624231 1989
697
Liver uricase in Camelus dromedarius: purification and properties. 61
2620492 1989
698
Comparative immunology of mammalian uricase using anti-hog liver uricase. 61
2495886 1989
699
Morphological and functional modifications of rat liver peroxisomal subpopulations during cold exposure. 61
2721643 1989
700
Effects of 3,5,3'-triiodothyronine (T3) on rat liver peroxisomal compartment during cold exposure. 61
2721644 1989
701
Uricase protein sequences: conserved during vertebrate evolution but absent in humans. 61
3192041 1988
702
Cloning and sequence analysis of cDNA for rat liver uricase. 61
3182808 1988
703
Selective induction of peroxisomal enzymes by the hypolipidemic drug bezafibrate. Detection of modulations by automatic image analysis in conjunction with immunoelectron microscopy and immunoblotting. 61
2903052 1988
704
Use of polyethylene glycol-modified uricase (PEG-uricase) to treat hyperuricemia in a patient with non-Hodgkin lymphoma. 61
3289428 1988
705
Nucleotide sequence of cDNA and predicted amino acid sequence of rat liver uricase. 61
3267221 1988
706
Localization of urate oxidase in the crystalline cores of rat liver peroxisomes by immunocytochemistry and immunoblotting. 61
3346536 1988
707
Interference of the chemotherapeutic agent etoposide with the direct phosphotungstic acid method for uric acid. 61
3479271 1987
708
Expression of nodule-specific genes in Phaseolus vulgaris L. 61
24277190 1987
709
A cytochemical study of the livers of rats treated with diethylnitrosamine/phenobarbital, with benzidine/phenobarbital, with phenobarbital, or with clofibrate. 61
2823419 1987
710
Interstitial ascorbate in turtle brain is modulated by release and extracellular volume change. 61
3625202 1987
711
Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. 61
3689345 1987
712
Cellular compartmentation of ureide biogenesis in root nodules of cowpea (Vigna unguiculata (L.) Walp.). 61
24225867 1987
713
Appearance of purine-catabolizing enzymes in fix and fix root nodules on soybean and effect of oxygen on the expression of the enzymes in callus tissue. 61
16665719 1987
714
Evidence for the transport function of uricase, an oxidative enzyme. 61
3661720 1987
715
Purification, cDNA Cloning, and Developmental Expression of the Nodule-Specific Uricase from Phaseolus vulgaris L. 61
16665575 1987
716
Deproteinizing methods evaluated for determination of uric acid in serum by reversed-phase liquid chromatography with ultraviolet detection. 61
3608161 1987
717
Biogenesis of peroxisomes in regenerating rat liver. I. Sequential changes of catalase and urate oxidase detected by ultrastructural cytochemistry. 61
3622522 1987
718
Induction and de novo synthesis of uricase, a nitrogen-regulated enzyme in Neurospora crassa. 61
2952636 1987
719
Does morphine enhance the release of 5-hydroxytryptamine in the rat spinal cord? An in vivo differential pulse voltammetry study. 61
2440518 1987
720
Transient response of encapsulated enzymes in hollow-fiber reactor. 61
18576482 1987
721
[Circadian rhythm of uric acid levels of the serum in gout]. 61
3589998 1987
722
Comparison of intraperoxisomal localization form and properties of amphibian (Rana catesbeiana) uricase with those of other animal uricases. 61
3493879 1987
723
Insoluble uricase in liver peroxisomes of Old World monkeys. 61
3427896 1987
724
Postnatal development of hepatic uricase and peroxisomes in baby pigs. 61
3427926 1987
725
Spectrophotometric assay of xanthine oxidase with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen. 61
3802544 1987
726
Generation of allantoin from the oxidation of urate by cytochrome c and its possible role in Reye's syndrome. 61
3028263 1987
727
Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation. 61
3026367 1986
728
2,8-Dihydroxyadenine lithiasis. 61
3780004 1986
729
Evaluation of the spectrophotometric assay of guanase with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen. 61
3746203 1986
730
Genetic locus in Rhizobium japonicum (fredii) affecting soybean root nodule differentiation. 61
3009416 1986
731
Immunogold localization of nodule-specific uricase in developing soybean root nodules. 61
24240357 1986
732
Enzymes of ammonia assimilation and ureide biosynthesis in soybean nodules: effect of nitrate. 61
16664678 1986
733
Ultrastructural cytochemical localization of uricase in peroxisomes of rat liver. 61
3080517 1986
734
Immobilization of uricase on protamine bound to glass beads and its application to determination of uric acid. 61
3963371 1986
735
Ocular hyperuricosis in the rabbit following hyperuricemia and topical epinephrine. 61
3503097 1986
736
H2O2 formation during nucleotide degradation in the hypoxic rat liver: a quantitative approach. 61
2850267 1986
737
Comments on the uricase/peroxidase--phenol--4--aminoantipyrine reaction. 61
3000645 1986
738
Expression of nodule-specific uricase in soybean callus tissue is regulated by oxygen. 61
16453663 1986
739
[An enzymatic color test for determining uric acid by the uricase-phenol-aminoantipyrine method]. 61
3727742 1986
740
Amber nonsense mutations in regulatory and structural genes of the nitrogen control circuit of Neurospora crassa. 61
2965995 1986
741
Biphasic contraction of isolated guinea pig tracheal chains by superoxide radical. 61
2995255 1985
742
Primary structure of the soybean nodulin-35 gene encoding uricase II localized in the peroxisomes of uninfected cells of nodules. 61
16593585 1985
743
Inhibition of uricase by pyrimidine and purine drugs. 61
4042322 1985
744
Acute monoarthritis associated with lipid liquid crystals. 61
2992399 1985
745
Role of uricase in the triggering of germination of Bacillus fastidiosus spores. 61
4038258 1985
746
In vivo voltammetric evidence of production of uric acid by rat caudate. 61
4005552 1985
747
The all2 gene is required for the induction of the purine deamination pathway in Schizosaccharomyces pombe. 61
4020341 1985
748
Effects of antilipolytic agents on rat liver peroxisomes and peroxisomal oxidative activities. 61
3978124 1985
749
Characterization of Peroxisomes from the Alga Bumilleriopsis filiformis. 61
16664045 1985
750
[Why Dalmatians excrete uric acid. Causes and consequences of a classical metabolic disorder]. 61
4071531 1985
751
Conservation of vitamin C by uric acid in blood. 61
3836238 1985
752
Studies on antigenicity of the polyethylene glycol (PEG)-modified uricase. 61
2412977 1985
753
Uricase from fish liver: isolation and some properties. 61
4092430 1985
754
Hyperuricaemia in sickle cell disease. 61
6528354 1984
755
Defect of uric acid uptake in Dalmatian dog liver. 61
6510499 1984
756
Uptake of uric acid, xanthine and hypoxanthine by brush-border membrane vesicles from mouse small intestine. 61
6509051 1984
757
Differential pulse voltammetry: simultaneous in vivo measurement of ascorbic acid, catechols and 5-hydroxyindoles in the rat striatum. 61
6083820 1984
758
Evaluation of the enzymatic assay of serum uric acid with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen. 61
6517491 1984
759
The determination of molecular weight of proteins by gel permeation chromatography in organic solvents. 61
6480578 1984
760
Interference in colorimetric reactions for measuring hydrogen peroxide. 61
6210015 1984
761
Problems associated with the measurement of uric acid using two enzyme-mediated reaction systems. 61
6508211 1984
762
Highly sensitive flow injection analysis of glucose and uric acid in serum using an immobilized enzyme column and chemiluminescence. 61
6520074 1984
763
Purine synthesis and catabolism in soybean seedlings : the biogenesis of ureides. 61
16663743 1984
764
[A problem on the uric acid value of rats for clinical evaluation]. 61
6499936 1984
765
Technicon SMAC methods for uric acid: uricase and phosphotungstate compared. 61
6733923 1984
766
Induction and origin of hepatocytes in rat pancreas. 61
6202703 1984
767
Hypouricaemic effect after oral administration in chickens of polyethylene glycol-modified uricase entrapped in liposomes. 61
6145782 1984
768
Voltammetric carbon paste electrodes monitor uric acid and not 5-HIAA at the 5-hydroxyindole potential in the rat brain. 61
6203061 1984
769
Genetic studies of purine breakdown in the fission yeast Schizosaccharomyces pombe. 61
24177583 1984
770
Role of hyperuricaemia in critically ill patients especially newborns. 61
6383436 1984
771
Induction of tolerance in mice by uricase and monomethoxypolyethylene glycol-modified uricase. 61
6746105 1984
772
Differential pulse voltammetry in vivo--evidence that uric acid contributes to the indole oxidation peak. 61
6200805 1983
773
Measuring urate in the Technicon SMAC by using unbound uricase and omitting dialysis. 61
6627647 1983
774
Uricase from soybean root nodules: purification, properties, and comparison with the enzyme from cowpea. 61
6685457 1983
775
Separation and quantitation of oxypurines by isocratic high-pressure liquid chromatography: application to xanthinuria and the Lesch-Nyhan syndrome. 61
6651793 1983
776
Reversible alteration of hepatic messenger RNA species for peroxisomal and non-peroxisomal proteins induced by the hypolipidaemic drug Wy-14,643. 61
6626161 1983
777
Ontogeny of hepatic peroxisomal uricase activity in the mongrel puppy. 61
6622104 1983
778
Automated analysis of flour extracts for uric acid and its correlation with degree of insect defilement. 61
6863185 1983
779
Enzymes of ureide synthesis in pea and soybean. 61
16662981 1983
780
Isolation and characterization of infected and uninfected cells from soybean nodules : role of uninfected cells in ureide synthesis. 61
16662921 1983
781
Enzymes of purine metabolism in cancer. 61
6861338 1983
782
Status of glutathione in the rat liver. Enhanced formation of oxygen radicals at low oxygen tension. 61
6670997 1983
783
Nodulin-35: a subunit of specific uricase (uricase II) induced and localized in the uninfected cells of soybean nodules. 61
16453488 1983
784
[Uric acid determination in dilute serum with an enzyme electrochemical and enzyme-free sensor]. 61
6670996 1983
785
Kinetic method having a linear range for substrate concentrations that exceed Michaelis-Menten constants. 61
7139915 1982
786
Phthalate esters as peroxisome proliferator carcinogens. 61
6754363 1982
787
Four methods for determining uric acid compared with a candidate reference method. 61
7127737 1982
788
Cluster bean-a ureide- or amide-producing legume? 61
16662600 1982
789
[Cold adaptation and changes in peroxisome enzyme in various organs of the rat]. 61
6128006 1982
790
Enzymes of amide and ureide biogenesis in developing soybean nodules. 61
16662397 1982
791
Evaluation of the Technicon bound uricase method for the determination of uric acid in urine. 61
7108450 1982
792
Urate does not influence the formation of calcium oxalate crystals in whole human urine at pH 5.3. 61
7067361 1982
793
Screening procedure for uric acid as indicator of infestation in spices. 61
7085543 1982
794
Uric acid determinations: reversed-phase liquid chromatography with ultraviolet detection compared with kinetic and equilibrium adaptations of the uricase method. 61
7067092 1982
795
Urate uptake in membrane vesicles of rat renal cortex: effect of copper. 61
7065132 1982
796
A candidate reference method for uric acid in serum. I. Optimization and evaluation. 61
7055949 1982
797
A candidate reference method for uric acid in serum. II. Interlaboratory testing. 61
7055950 1982
798
Detection of uric acid in aqueous humor by high pressure liquid chromatography. 61
7186433 1982
799
Two-point kinetic determination of uric acid in serum with uricase, catalase and aldehyde dehydrogenase on the KONE CD analyser. 61
18927832 1982
800
Physicochemical properties and states of sulfhydryl groups of uricase from Candida utilis. 61
7200091 1982
801
Immobilized uricase for automated assay of uric acid in serum. 61
18927827 1982
802
Ultrastructural localization of urate oxidase in nodules of Sesbania exaltata, Glycine max, and Medicago sativa. 61
7201988 1982
803
[Effect of temperature increase on some aspects of nitrogen catabolism in rainbow trout (Salmo gairdneri Rich.)]. 61
7156505 1982
804
Peroxisomal enzyme activities in regenerating liver of rats. 61
6131509 1982
805
Ontogeny of renal uric acid excretion in the mongrel puppy. 61
7322672 1981
806
Enzymes of Purine Biosynthesis and Catabolism in Glycine max: I. COMPARISON OF ACTIVITIES WITH N(2) FIXATION AND COMPOSITION OF XYLEM EXUDATE DURING NODULE DEVELOPMENT. 61
16662061 1981
807
Reduction of plasma urate levels in the cockerel with polyethylene glycol-uricase. 61
7288624 1981
808
The application of a sensitive uricase-peroxidase couple reaction to a centrifugal fast analyser for the determination of uric acid. 61
7296893 1981
809
Modification of amino groups in Candida utilis uricase with naphthoquinone disulfonic acid in relation to the enzymic activity. 61
9222322 1981
810
Uricase immobilized onto nylon tube for use in automated analysis of serum urate. 61
7304984 1981
811
Localization of enzymes of ureide biosynthesis in peroxisomes and microsomes of nodules. 61
16661891 1981
812
Gut bacteria recycle uric acid nitrogen in termites: A strategy for nutrient conservation. 61
16593064 1981
813
Ureide Synthesis in a Cell-Free System from Cowpea (Vigna unguiculata [L.] Walp.) Nodules : STUDIES WITH O(2), pH, AND PURINE METABOLITES. 61
16661827 1981
814
The analysis of serum urate utilizing immobilized uricase. 61
24233654 1981
815
The acute effects of furosemide, ethacrynic acid and chlorothiazide on the renal tubular handling of uric acid in the chicken. 61
7205623 1981
816
[Study of crystals in synovial exudations with simultaneous determination of adequate enzymes]. 61
7223082 1981
817
Some kinetic studies on immobilized uricase. 61
7297747 1981
818
Uricase immobilized on walls of glass tubes used as reactors in continuous-flow analyses. 61
7449106 1981
819
Improved modification of yeast uricase with polyethylene glycol, accompanied with nonimmunoreactivity towards anti-uricase serum and high enzymic activity. 61
7194181 1981
820
Continuous-flow analysis for uric acid in biological fluids, with immobilized uricase in a closed-loop system. 61
7457889 1980
821
A new method for the determination of serum uric acid by measuring allantoid produced by the action of uricase. 61
7214610 1980
822
Uric Acid-Degrading Bacteria in Guts of Termites [Reticulitermes flavipes (Kollar)]. 61
16345587 1980
823
Thermodynamics and stoicheiometry of the binding of substrate analogues to uricase. 61
6821367 1980
824
Non-classical inhibition of uricase by cyanide. 61
6821368 1980
825
Purification and characterization of yeast protease B. 61
6993457 1980
826
Purification and characterization of uricase, a nitrogen-regulated enzyme, from Neurospora crassa. 61
6446884 1980
827
Determination of uric acid with uricase and peroxidase. 61
7357749 1980
828
Use of 3,5-dichloro-2-hydroxybenzenesulfonic acid/4-aminophenazone chromogenic system in direct enzymic assay of uric acid in serum and urine. 61
7353268 1980
829
[Nitrogen excretion of Helix aspersa Müller (Mollusca Gastropoda Pulmonata)]. 61
7224493 1980
830
Fibrin membrane endowed with biological function. V. Multienzyme complex of uricase, catalase, allantoinase and allantoicase. 61
6985799 1980
831
A new spectrophotometric assay for enzymes of purine metabolism. IV. Determination of adenosine deaminase. 61
7363876 1980
832
Nitrogen regulation of uricase synthesis in Neurospora crassa. 61
160493 1979
833
The use of immobilized enzyme reactors in continuous-flow analyzers for the determination of glucose, urea, and uric acid. 61
476924 1979
834
A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment. 61
518562 1979
835
Hyperxanthinemia interferes with serum uric acid determinations by the uricase method. 61
455692 1979
836
Serum uric acid. 61
474510 1979
837
A micromethod for plasma uric acid determinations in companion birds. 61
526210 1979
838
Ox kidney uricase: a new method of purification. 61
521256 1979
839
Main properties of ox kidney uricase. 61
42632 1979
840
Use of immobilized enzymes in automated clinical analysis: determination of uric acid and glucose using immobilized enzymes in column form. 61
527227 1979
841
Evaluation of three clinical chemical routine methods for the determination of serum uric acid, by mass fragmentography. 61
527221 1979
842
Fluorometric determination of xanthine and hypoxanthine in tissue. 61
583329 1979
843
Degradation of uric acid to urea and glyoxylate in peroxisomes. 61
447647 1979
844
Positive interference of catecholamine metabolites with quantitation of urinary uric acid by the direct acid ferric-reduction method. 61
436251 1979
845
Improved automated kinetic determination of uric acid in serum by use of uricase/catalase/aldehyde dehydrogenase. 61
466770 1979
846
Mechanism of uricase action. 61
36153 1979
847
Adrenal epinephrine in hyperuricemia induced by hypothalamic stimulation of the rat. 61
426051 1979
848
Thymol is a suitable preservative for uric acid standards in the uricase technique. 61
759034 1979
849
In vitro and in vivo activity of soluble cross-linked uricase-albumin polymers: a model for enzyme therapy. 61
763074 1979
850
Immobilized enzymes in continuous-flow analysis. 61
761373 1979
851
A new spectrophotometric assay for enzymes of purine metabolism. I. Determination of xanthine oxidase activity. 61
488056 1979
852
A new spectrophotometric assay for enzymes of purine metabolism. II. Determination of guanase activity. 61
488057 1979
853
Purification of uricase from mammalian tissue. 61
35787 1979
854
Modification of yeast uricase with polyethylene glycol: disappearance of binding ability towards anti-uricase serum. 61
573687 1979
855
Uricase of Bacillus fastidiosus. Properties and regulation of synthesis. 61
728443 1978
856
Allantoxanamide: a potent new uricase inhibitor in vivo. 61
723476 1978
857
Chromosomal location of genes participating in the degradation of purines in Pseudomonas aeruginosa. 61
104142 1978
858
Immobilized-enzyme membrane sandwich reactor used in automated micro-scale assay of plasma uric acid. 61
709842 1978
859
New enzymatic method for serum uric acid at 500 nm. 61
709818 1978
860
Isolation and biochemical properties of two types of microbody from Neurospora crassa cells. 61
152214 1978
861
Allantoin and Allantoic Acid in the Nitrogen Economy of the Cowpea (Vigna unguiculata [L.] Walp.). 61