UOX
MCID: URT049
MIFTS: 26

Urate Oxidase, Pseudogene (UOX)

Aliases & Classifications for Urate Oxidase, Pseudogene

MalaCards integrated aliases for Urate Oxidase, Pseudogene:

Name: Urate Oxidase, Pseudogene 57 13
Uricase 57
Uox 57

External Ids:

OMIM 57 191540

Summaries for Urate Oxidase, Pseudogene

OMIM : 57 In most mammals, the activity of urate oxidase (EC 1.7.3.3) catalyzes the oxidation of uric acid to allantoin; humans and some primates lack this enzyme activity. The loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia, a metabolic disturbance that can lead to gouty arthritis and renal stones (summary by Wu et al., 1994). (191540)

MalaCards based summary : Urate Oxidase, Pseudogene, also known as uricase, is related to gout and hyperuricemia. An important gene associated with Urate Oxidase, Pseudogene is UOX (Urate Oxidase (Pseudogene)). The drugs Febuxostat and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and endothelial.

Related Diseases for Urate Oxidase, Pseudogene

Diseases related to Urate Oxidase, Pseudogene via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 16, show less)
# Related Disease Score Top Affiliating Genes
1 gout 10.9
2 hyperuricemia 10.8
3 diabetes insipidus, nephrogenic, autosomal 10.2
4 lymphoma, hodgkin, classic 10.2
5 lymphoma, non-hodgkin, familial 10.2
6 diabetes insipidus 10.2
7 burkitt lymphoma 10.1
8 hepatocellular carcinoma 10.1
9 nephrolithiasis, calcium oxalate 10.1
10 wilms tumor 5 10.1
11 hyperglycemia 10.1
12 uremia 10.1
13 severe combined immunodeficiency 10.1
14 fatty liver disease 10.1
15 acute respiratory distress syndrome 10.1
16 rapidly involuting congenital hemangioma 10.1

Graphical network of the top 20 diseases related to Urate Oxidase, Pseudogene:



Diseases related to Urate Oxidase, Pseudogene

Symptoms & Phenotypes for Urate Oxidase, Pseudogene

Clinical features from OMIM:

191540

Drugs & Therapeutics for Urate Oxidase, Pseudogene

Drugs for Urate Oxidase, Pseudogene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 48, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Febuxostat Approved Phase 4 144060-53-7 134018
2
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
3
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
4
Norethindrone Approved Phase 4 68-22-4 6230
5
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
6
Polyestradiol phosphate Approved Phase 4 28014-46-2
7
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
8
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
9
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
10
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
11
Uric acid Investigational Phase 4 69-93-2 1175
12 Tocotrienol Investigational Phase 4 6829-55-6
13 Antirheumatic Agents Phase 4
14 Antioxidants Phase 4
15 Protective Agents Phase 4
16 Pharmaceutical Solutions Phase 4
17 Angiotensinogen Phase 4
18 Giapreza Phase 4
19 Contraceptives, Oral Phase 4
20 Sodium Chloride Symporter Inhibitors Phase 4
21 Antihypertensive Agents Phase 4
22 Estrogens Phase 4
23 Progestins Phase 4
24 Natriuretic Agents Phase 4
25 HIV Protease Inhibitors Phase 4
26 Hormones Phase 4
27 diuretics Phase 4
28 Contraceptive Agents Phase 4
29
protease inhibitors Phase 4
30 Norethindrone Acetate Phase 4
31 Estradiol 17 beta-cypionate Phase 4
32 Angiotensin-Converting Enzyme Inhibitors Phase 4
33 Hormone Antagonists Phase 4
34 Estradiol 3-benzoate Phase 4
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
36 Antineoplastic Agents, Phytogenic Phase 4
37 insulin Phase 4
38 Silybin Phase 4
39 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
40 Tocopherols Phase 4
41 Insulin, Globin Zinc Phase 4
42 Tocotrienols Phase 4
43 Vitamins Phase 4
44 Lecithin Phase 4
45
Allopurinol Approved Phase 2 315-30-0 2094
46
Sirolimus Approved, Investigational Phase 2 53123-88-9 6436030 5284616 46835353
47
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
48
Rasburicase Approved, Investigational Phase 1 134774-45-1

Interventional clinical trials:

(showing 19, show less)
# Name Status NCT ID Phase Drugs
1 Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS) Completed NCT01328769 Phase 4 Febuxostat;Placebo
2 Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women. Completed NCT03921736 Phase 4 Perindopril;Hydrochlorothiazide;Estracomb TTS
3 Metabolic and Vascular Effects of Silybin in Hypertensive Patients With High One-hour Post-load Plasma Glucose: a Single Arm Pilot Study Completed NCT03538327 Phase 4 Silybin
4 Randomized, Multicenter, Double-blind, Placebo-controlled Efficacy and Safety Study of 8 mg PEG-uricase in Two Dose Regimens in Hyperuricemic Subjects With Symptomatic Gout Completed NCT00325195 Phase 3
5 Multicenter, Open Label Extension Study of 8 mg PEG-uricase in Subjects Who Completed Protocols C0405 or C0406 for Symptomatic Gout Completed NCT01356498 Phase 3
6 A Phase II Multidose Study of Intravenous PEG-uricase in Patients With Refractory Gout Completed NCT00111657 Phase 2
7 An Open Label Phase II Multiple Dose Safety, Pharmacokinetic and Pharmacodynamics Study of SEL-212 Followed by Open Label Administration of SEL-037 in Subjects With Symptomatic Gout and Elevated Blood Uric Acid Completed NCT02959918 Phase 2 SEL-212;SEL-037;SVP-rapamycin (SEL-110)
8 A Study to Compare the Efficacy of SEL-212 to KRYSTEXXA® in Gout Patients Refractory to Conventional Therapy Recruiting NCT03905512 Phase 2 SEL-212;SEL-037;SEL-110;KRYSTEXXA®
9 ULTRA-T2D Study: Uric Acid Lowering Trial in Youth Onset T2D Not yet recruiting NCT03899883 Phase 2 Pegloticase 8 MG/ML [Krystexxa]
10 A Cohort Dose-Escalation Phase 1 Study of Intramuscular Injection of Uricase-PEG 20 Unknown status NCT01038947 Phase 1
11 A Cohort Dose-Escalation Phase 1 Study of Intravenous Infusion of Uricase-PEG 20 Unknown status NCT01021241 Phase 1
12 An Open-Label, Sequential, Ascending Single-Dose Safety, Tolerability, Pharmacokinetic and Pharmacodynamics Study of an Intravenous Infusion of SEL-037 in Subjects With Elevated Blood Uric Acid Levels Completed NCT02464605 Phase 1
13 A Phase I Single Ascending Dose Safety, Pharmacokinetic and Pharmacodynamics Study of SEL-212 in Subjects With Elevated Blood Uric Acid Completed NCT02648269 Phase 1 SEL-110
14 The Relationship Between Uric Acid and Inflammatory Markers Completed NCT01323335 Phase 1 IV Uric Acid;IV Rasburicase
15 A Randomized, Double-blinded, Placebo-controlled, Single-dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SSS11 Administered Intravenously in Healthy Volunteers. Recruiting NCT03388515 Phase 1
16 An Open Label, Single-dose, Dose-increasing Study to Assess the Safety, Tolerability, PK and Preliminary PD of PEGylated Recombinant Candida Urate Oxidase (SSS11) for Injection in Chinese Healthy Adult Volunteers Not yet recruiting NCT04047394 Phase 1 PEGylated recombinant candida urate oxidase
17 Association of Maternal Uric Acid With Maternal Condition and Fetal Outcome in Pregnant Women With Hypertension Unknown status NCT01523327
18 Differential Effects of Uric Acid and Xanthine Oxidoreductase on Endothelial Function and Oxydative Stress Recruiting NCT03395977 Placebos;Febuxostat;Rasburicase
19 Paediatric Obesity and Cardiovascular Dysfunction: Searching for Early Markers of Damage Active, not recruiting NCT03169257

Search NIH Clinical Center for Urate Oxidase, Pseudogene

Genetic Tests for Urate Oxidase, Pseudogene

Anatomical Context for Urate Oxidase, Pseudogene

MalaCards organs/tissues related to Urate Oxidase, Pseudogene:

41
Liver, Kidney, Endothelial, Testes, Brain, Heart, Retina

Publications for Urate Oxidase, Pseudogene

Articles related to Urate Oxidase, Pseudogene:

(showing 1014, show less)
# Title Authors PMID Year
1
Evolutionary history and metabolic insights of ancient mammalian uricases. 38 8
24550457 2014
2
Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. 38 8
8290593 1994
3
Structural analysis of the gene encoding rat uricase. 38 8
1783398 1991
4
Urate oxidase: primary structure and evolutionary implications. 38 8
2594778 1989
5
A human genomic sequence highly homologous to the 3'-untranslated region of rat uricase mRNA. 38 8
3178807 1988
6
Localization of the human urate oxidase gene (UOX) to 1p22. 8
1395718 1992
7
Human urate oxidase gene: cloning and partial sequence analysis reveal a stop codon within the fifth exon. 8
2403354 1990
8
Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase. 8
3344434 1988
9
A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. 8
3029599 1987
10
HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. 8
3821905 1987
11
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? 8
13937884 1962
12
A ratiometric fluorescent probe for detection of uric acid based on the gold nanoclusters-quantum dots nanohybrid. 38
31176998 2019
13
Screening of single or combined administration of 9 probiotics to reduce ammonia emissions from laying hens. 38
30982063 2019
14
Application of cyclic voltammetry to analyse uric acid and reducing agents in commercial milks. 38
31151606 2019
15
Toxicity assessment of wearable wound sensor constituents on keratinocytes. 38
30928693 2019
16
Antioxidant capacities in various animal sera as measured with multiple free-radical scavenging method. 38
31272792 2019
17
Nanozymes: From New Concepts, Mechanisms, and Standards to Applications. 38
31276379 2019
18
Pegloticase Treatment Significantly Decreases Blood Pressure in Patients With Chronic Gout. 38
31079535 2019
19
Mouse models for human hyperuricaemia: a critical review. 38
31118497 2019
20
Serum Urate, Uricase, and Blood Pressure Control in Gout. 38
31079534 2019
21
Uricase grafted nanoconducting matrix based electrochemical biosensor for ultrafast uric acid detection in human serum samples. 38
30797811 2019
22
Fabrication of an efficient and sensitive colorimetric biosensor based on Uricase/ Th-MOF for uric acid sensing in biological samples. 38
31220726 2019
23
Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy. 38
31253939 2019
24
A nanocomposite prepared from copper(II) and nitrogen-doped graphene quantum dots with peroxidase mimicking properties for chemiluminescent determination of uric acid. 38
31161235 2019
25
Uricase and Horseradish Peroxidase Hybrid CaHPO₄ Nanoflower Integrated with Transcutaneous Patches for Treatment of Hyperuricemia. 38
30890227 2019
26
Statistical media optimization for the production of clinical uricase from Bacillus subtilis strain SP6. 38
31193400 2019
27
Association between Serum Uric Acid Level with Presence and Severity of Coronary Artery Disease. 38
31311215 2019
28
Urate-lowering therapy alleviates atherosclerosis inflammatory response factors and neointimal lesions in a mouse model of induced carotid atherosclerosis. 38
30690853 2019
29
Uric acid analogue as a possible xenobiotic marker of uric acid transporter Urat1 in rats. 38
30826184 2019
30
Uric acid therapy for vasculoprotection in acute ischemic stroke. 38
31334357 2019
31
Advanced Colorimetric Paper Sensors Using Color Focusing Effect Based on Asymmetric Flow of Fluid. 38
30950270 2019
32
Potential Dangers of Serum Urate-Lowering Therapy. 38
30611833 2019
33
Nonenzymatic Serum Antioxidant Capacity in IBD and Its Association with the Severity of Bowel Inflammation and Corticosteroids Treatment. 38
30986917 2019
34
Pharmacological urate-lowering approaches in chronic kidney disease. 38
30769179 2019
35
Production and Characterization of Recombinant Wild Type Uricase from Indonesian Coelacanth (L. menadoensis) and Improvement of Its Thermostability by In Silico Rational Design and Disulphide Bridges Engineering. 38
30871218 2019
36
An electrochemical biosensor based on novel butylamine capped CZTS nanoparticles immobilized by uricase for uric acid detection. 38
30597431 2019
37
Antioxidant properties of citric acid interfere with the uricase-based measurement of circulating uric acid. 38
30447534 2019
38
A highly selective and sensitive colorimetric detection of uric acid in human serum based on MoS2-catalyzed oxidation TMB. 38
30542813 2019
39
Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease. 38
29847340 2019
40
Zwitterionic Hydrogels Based on a Degradable Disulfide Carboxybetaine Cross-Linker. 38
30119608 2019
41
Electrochemical Detection for Uric Acid Based on β-Lactoglobulin-Functionalized Multiwall Carbon Nanotubes Synthesis with PtNPs Nanocomposite. 38
30634585 2019
42
Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia. 38
30951542 2019
43
U-Shaped Association Between Serum Uric Acid Levels and Cognitive Functions in Patients with Type 2 Diabetes: A Cross-Sectional Study. 38
30958355 2019
44
Review of the Literature Examining the Association of Serum Uric Acid with Osteoporosis and Mechanistic Insights into Its Effect on Bone Metabolism. 38
30387405 2019
45
A Chromatin-Mimetic Nanomedicine for Therapeutic Tolerance Induction. 38
30412375 2018
46
A Case Report of Immunosuppressant Medication‒Associated Polyarticular Tophaceous Gout Successfully Treated Using the Polyethylene Glycol‒Conjugated Uricase Enzyme Pegloticase. 38
30577324 2018
47
Tophus resolution in patients with chronic refractory gout who have persistent urate-lowering responses to pegloticase. 38
30594229 2018
48
Investigation on uric acid biosensor model for enzyme layer thickness for the application of arthritis disease diagnosis. 38
29713461 2018
49
Enzymatic determination of uric acid using water-soluble CuInS/ZnS quantum dots as a fluorescent probe. 38
30291453 2018
50
Adaptive effect of sericin on hepatic mitochondrial conformation through its regulation of apoptosis, autophagy and energy maintenance: a proteomics approach. 38
30297713 2018
51
[Recent advances in gout: pathogenesis, diagnosis, comorbidities, treatment]. 38
30277413 2018
52
Comparative genomics of the Erwinia and Enterobacter olive fly endosymbionts. 38
30374192 2018
53
Nanoscale Enzymatic Compartments in Tandem Support Cascade Reactions in Vitro. 38
30180548 2018
54
Expert opinion on emerging urate-lowering therapies. 38
30244605 2018
55
Evaluation of two sterically directed attachments of biomolecules on a coaxial nanofibre membrane to improve the development of optical biosensors. 38
29853069 2018
56
Efficient purification of a recombinant tag-free thermostable Kluyveromyces marxianus uricase by pH-induced self-cleavage of intein and expression in Escherichia coli. 38
30221113 2018
57
Uricase-free on-demand colorimetric biosensing of uric acid enabled by integrated CoP nanosheet arrays as a monolithic peroxidase mimic. 38
29681277 2018
58
Hypouricemic and Antioxidant Effects of Soy Vinegar Extracts in Hyperuricemic Mice. 38
30132721 2018
59
Emergent nanotherapies in microcrystal-induced arthritis. 38
29890413 2018
60
Reduced graphene oxide-ZnO nanocomposite based electrochemical sensor for sensitive and selective monitoring of 8-hydroxy-2'-deoxyguanosine. 38
29759240 2018
61
Different Catabolism Pathways Triggered by Various Methylxanthines in Caffeine-Tolerant Bacterium Pseudomonas putida CT25 Isolated from Tea Garden Soil. 38
29926702 2018
62
Spatial Confined Synergistic Enzymes with Enhanced Uricolytic Performance and Reduced Toxicity for Effective Gout Treatment. 38
30035856 2018
63
A multifunctional material based on co-electrospinning for developing biosensors with optical oxygen transduction. 38
29530253 2018
64
Synovial fluid uric acid level aids diagnosis of gout. 38
29930806 2018
65
Ultrasound assisted process intensification of uricase and alkaline protease enzyme co-production in Bacillus licheniformis. 38
29705310 2018
66
Polypeptides with High Zwitterion Density for Safe and Effective Therapeutics. 38
29707870 2018
67
Dextrin-uricase conjugate: Preparation, characterization, and enzymatic properties. 38
29292142 2018
68
Investigational drugs for hyperuricemia, an update on recent developments. 38
29718730 2018
69
Zwitterionic Nanocages Overcome the Efficacy Loss of Biologic Drugs. 38
29457278 2018
70
Sensitive colorimetric assay for uric acid and glucose detection based on multilayer-modified paper with smartphone as signal readout. 38
29455281 2018
71
Association between serum uric acid concentrations and grip strength: Is there effect modification by age? 38
28139280 2018
72
Self-Catalyzing Chemiluminescence of Luminol-Diazonium Ion and Its Application for Catalyst-Free Hydrogen Peroxide Detection and Rat Arthritis Imaging. 38
29285924 2018
73
Earliest evidence of caries lesion in hominids reveal sugar-rich diet for a Middle Miocene dryopithecine from Europe. 38
30161214 2018
74
Evaluation of ADA activity as a potential marker of disease severity in psoriasis patients. 38
30234006 2018
75
Preparation, Characterization, and Application of Enzyme Nanoparticles. 38
30244789 2018
76
Impact of pegloticase on patient outcomes in refractory gout: current perspectives. 38
30425593 2018
77
CeO2-x/C/rGO nanocomposites derived from Ce-MOF and graphene oxide as a robust platform for highly sensitive uric acid detection. 38
29319098 2018
78
Serum Uric Acid as an Independent Risk Factor for the Presence and Severity of Early-Onset Coronary Artery Disease: A Case-Control Study. 38
30425752 2018
79
Hypertension as Determinant of Hyperuricemia: A Case Control Study from the Sub-Himalayan Region in North India. 38
30341839 2018
80
Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders. 38
28729031 2018
81
Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate. 38
30391956 2018
82
Optimization of novel and greener approach for the coproduction of uricase and alkaline protease in Bacillus licheniformis by Box-Behnken model. 38
28976246 2018
83
Uricase based fluorometric determination of uric acid based on the use of graphene quantum dot@silver core-shell nanocomposites. 38
29594655 2017
84
Uric acid contributes greatly to hepatic antioxidant capacity besides protein. 38
28937257 2017
85
Bioengineered robust hybrid hydrogels enrich the stability and efficacy of biological drugs. 38
28412223 2017
86
Pegloticase in gout treatment - safety issues, latest evidence and clinical considerations. 38
29204266 2017
87
The association between serum uric acid and blood pressure in different age groups in a healthy Chinese cohort. 38
29390287 2017
88
Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China. 38
29275349 2017
89
A facile strategy for enzyme immobilization with highly stable hierarchically porous metal-organic frameworks. 38
29112218 2017
90
Designing a mutant Candida uricase with improved polymerization state and enzymatic activity. 38
29161434 2017
91
Data for high-throughput estimation of specific activities of enzyme/mutants in cell lysates through immunoturbidimetric assay of proteins. 38
28795101 2017
92
Nanomolar Level Detection of Uric Acid in Blood Serum and Pest-Infested Grain Samples by an Amphiphilic Probe. 38
28795801 2017
93
High-throughput estimation of specific activities of enzyme/mutants in cell lysates through immunoturbidimetric assay of proteins. 38
28526525 2017
94
Significance of Serum Uric Acid in Pregnancy Induced Hypertension. 38
28987249 2017
95
Novel lipidic and bienzymatic nanosomes for efficient delivery and enhanced bioactivity of catalase. 38
28888973 2017
96
Allantoin contributes to the stress response in cadmium-treated Arabidopsis roots. 38
28858669 2017
97
Low serum uric acid levels in chronic insomnia patients: A case-control study. 38
28801272 2017
98
Acute effects of thermally processed pili (Canarium ovatum, Engl.) pomace drink on plasma antioxidant and polyphenol status in humans. 38
29062808 2017
99
Uric acid in plants and microorganisms: Biological applications and genetics - A review. 38
28748114 2017
100
A rapid and high-throughput method for the determination of serum uric acid based on microarray technology and nanomaterial. 38
27862937 2017
101
Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis). 38
28302963 2017
102
Catalase increases ethanol oxidation through the purine catabolism in rat liver. 38
28527616 2017
103
Electrochromic Sensor for Multiplex Detection of Metabolites Enabled by Closed Bipolar Electrode Coupling. 38
28750540 2017
104
Evaluating the urate-lowering effects of different microbial fermented extracts in hyperuricemic models accompanied with a safety study. 38
28911646 2017
105
Recombinant production of Aspergillus Flavus uricase and investigation of its thermal stability in the presence of raffinose and lactose. 38
28667645 2017
106
Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid. 38
28890842 2017
107
Erratum: Uricase alkaline enzymosomes with enhanced stabilities and anti-hyperuricemia effects induced by favorable microenvironmental changes. 38
28664903 2017
108
Gold nanoclusters as switch-off fluorescent probe for detection of uric acid based on the inner filter effect of hydrogen peroxide-mediated enlargement of gold nanoparticles. 38
28130993 2017
109
Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes. 38
28507007 2017
110
Biosensing platform for the detection of uric acid based on graphene quantum dots and G-quadruplex/hemin DNAzyme. 38
28366217 2017
111
Study of ZnS Nanostructures Based Electrochemical and Photoelectrochemical Biosensors for Uric Acid Detection. 38
28555028 2017
112
Physiological concentrations of soluble uric acid are chondroprotective and anti-inflammatory. 38
28539647 2017
113
Surface plasmon resonance biosensor for enzymatic detection of small analytes. 38
28287081 2017
114
Time to target uric acid to retard CKD progression. 38
27339448 2017
115
Solution Process Synthesis of High Aspect Ratio ZnO Nanorods on Electrode Surface for Sensitive Electrochemical Detection of Uric Acid. 38
28418039 2017
116
Impact of Mutations on the Higher Order Structure and Activity of a Recombinant Uricase. 38
28063825 2017
117
Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia. 38
28511370 2017
118
A Practical System for High-Throughput Screening of Mutants of Bacillus fastidiosus Uricase. 38
27614625 2017
119
Oral uricase eliminates blood uric acid in the hyperuricemic pig model. 38
28594873 2017
120
Effect of surfactants and inducers on increased uricase production under submerged fermentations by Bacillus cereus. 38
27071031 2017
121
[The phylogenetic theory of general pathology. The development of seven biological functions, seven specific ones and etiological factors of metabolic epidemics, millions years' common pathogenesis and basics of prevention.] 38
30802390 2017
122
Size-selective QD@MOF core-shell nanocomposites for the highly sensitive monitoring of oxidase activities. 38
27573301 2017
123
Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats. 38
28337250 2017
124
Upconversion ratiometric fluorescence and colorimetric dual-readout assay for uric acid. 38
27471157 2016
125
Allantoin Increases Cadmium Tolerance in Arabidopsis via Activation of Antioxidant Mechanisms. 38
27742885 2016
126
Rapid and highly-sensitive uric acid sensing based on enzymatic catalysis-induced upconversion inner filter effect. 38
27341137 2016
127
Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury. 38
27906636 2016
128
Urinary excretion of uric acid, allantoin, and 8-OH-Deoxyguanosine in uricase-knockout mice. 38
27906613 2016
129
Angiogenic factors are associated with multiple sclerosis. 38
27887749 2016
130
Utilizing intein-mediated protein cleaving for purification of uricase, a multimeric enzyme. 38
27702489 2016
131
Modification with polysialic acid-PEG copolymer as a new method for improving the therapeutic efficacy of proteins. 38
26829568 2016
132
Uric Acid Induces Cognitive Dysfunction through Hippocampal Inflammation in Rodents and Humans. 38
27798180 2016
133
Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles. 38
27479756 2016
134
Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism. 38
27465529 2016
135
Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout. 38
27352852 2016
136
Electrochemical detection of uric acid via uricase-immobilized graphene oxide. 38
27402177 2016
137
A Numerical Approach for Kinetic Analysis of the Nonexponential Thermoinactivation Process of Uricase. 38
27480193 2016
138
Nanocapsule assemblies as effective enzyme delivery systems against hyperuricemia. 38
27013130 2016
139
High fluorescence S, N co-doped carbon dots as an ultra-sensitive fluorescent probe for the determination of uric acid. 38
27216657 2016
140
Sodium butyrate mitigates in vitro ammonia generation in cecal content of laying hens. 38
27154844 2016
141
Extracorporeal delivery of a therapeutic enzyme. 38
27477538 2016
142
Iterative Outlier Removal: A Method for Identifying Outliers in Laboratory Recalibration Studies. 38
27197675 2016
143
Regulation of uric acid metabolism and excretion. 38
26316329 2016
144
Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization. 38
26509876 2016
145
Label-free and selective sensing of uric acid with gold nanoclusters as optical probe. 38
26992526 2016
146
Development of Therapeutic Chimeric Uricase by Exon Replacement/Restoration and Site-Directed Mutagenesis. 38
27213357 2016
147
Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone. 38
26907620 2016
148
Quantitative determination of uric acid using CdTe nanoparticles as fluorescence probes. 38
26433069 2016
149
Uric Acid and Coronary Artery Disease, Two Sides of a Single Coin: A Determinant of Antioxidant System or a Factor in Metabolic Syndrome. 38
27042498 2016
150
A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties. 38
28002433 2016
151
Uricase alkaline enzymosomes with enhanced stabilities and anti-hyperuricemia effects induced by favorable microenvironmental changes. 38
26823332 2016
152
DNA shuffling of uricase gene leads to a more "human like" chimeric uricase with increased uricolytic activity. 38
26526169 2016
153
Economic analysis of uricase production under uncertainty: Contrast of chromatographic purification and aqueous two-phase extraction (with and without PEG recycle). 38
26561271 2016
154
The Effect of the Mediterranean Diet on Serum Total Antioxidant Capacity in Obese Patients: A Randomized Controlled Trial. 38
25989426 2016
155
An analytical comparison between point-of-care uric acid testing meters. 38
26689648 2016
156
Fungal Community Associated with Dactylopius (Hemiptera: Coccoidea: Dactylopiidae) and Its Role in Uric Acid Metabolism. 38
27446001 2016
157
Horseradish peroxidase-catalyzed polymerization of L-DOPA for mono-/bi-enzyme immobilization and amperometric biosensing of H2O2 and uric acid. 38
26717822 2016
158
Uricosuric agents decrease the plasma urate level in rats by concomitant treatment with topiroxostat, a novel xanthine oxidoreductase inhibitor. 38
26589240 2016
159
Melamine Nephrotoxicity is Mediated by Hyperuricemia. 38
26777910 2015
160
Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics. 38
26276541 2015
161
Compound Tufuling Granules ([characters: see text]) regulate glucose transporter 9 expression in kidney to influence serum uric acid level in hyperuricemia mice. 38
25864117 2015
162
Low Serum Levels of Uric Acid are Associated With Development of Poststroke Depression. 38
26559256 2015
163
Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice. 38
26100496 2015
164
Crystal structure of Bacillus fastidious uricase reveals an unexpected folding of the C-terminus residues crucial for thermostability under physiological conditions. 38
25786739 2015
165
Purification and characterization of an extracellular uricase from a new isolate of Sphingobacterium thalpophilum (VITPCB5). 38
26145833 2015
166
[The Pharmacokinetics and Pharmacodynamics of Intravenous Uricase Multivesicular Liposomes]. 38
26619536 2015
167
Nanosomal Microassemblies for Highly Efficient and Safe Delivery of Therapeutic Enzymes. 38
26325262 2015
168
Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity. 38
26371311 2015
169
The Chronic Kidney Disease - Colonic Axis. 38
25855516 2015
170
Relationship of serum uric acid, serum creatinine and serum cystatin C with maternal and fetal outcomes in rural Indian pregnant women. 38
26583159 2015
171
The Urinary Uric Acid/Creatinine Ratio is An Adjuvant Marker for Perinatal Asphyxia. 38
26998526 2015
172
Uric acid as a modulator of glucose and lipid metabolism. 38
26133655 2015
173
[The Association Between Serum Uric Acid and Creatinine in Patients with Hypothyroidism]. 38
26619549 2015
174
Urate crystal degradation for treatment of gout: a nanoparticulate combination therapy approach. 38
25787730 2015
175
Cloning, Expression, and Purification of Recombinant Uricase Enzyme from Pseudomonas aeruginosa Ps43 Using Escherichia coli. 38
25588559 2015
176
A simple and sensitive fluorescence based biosensor for the determination of uric acid using H2O2-sensitive quantum dots/dual enzymes. 38
25113659 2015
177
Pharmacokinetics and pharmacodynamics of pegloticase in patients with end-stage renal failure receiving hemodialysis. 38
25816806 2015
178
No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse. 38
25565311 2015
179
Immobilization of Enzymes by Electrochemical and Chemical Oxidative Polymerization of L-DOPA to Fabricate Amperometric Biosensors and Biofuel Cells. 38
25938891 2015
180
Electrochemical performance and detection of 8-Hydroxy-2'-deoxyguanosine at single-stranded DNA functionalized graphene modified glassy carbon electrode. 38
25128367 2015
181
A novel third generation uric acid biosensor using uricase electro-activated with ferrocene on a Nafion coated glassy carbon electrode. 38
25461755 2015
182
Purification, characterization and in vitro application of a thermostable oxidant- and SDS-stable uricase from a newly isolated Bacillus firmus DWD-33. 38
25742044 2015
183
Amperometric uric acid biosensor based on poly(vinylferrocene)-gelatin-carboxylated multiwalled carbon nanotube modified glassy carbon electrode. 38
25618698 2015
184
[Preparation and characterization of uricase in uricase-catalase liposomes prepared using borate buffer]. 38
25736127 2015
185
Characterization of a Thermostable Uricase Isolated from Bacillus firmus DWD-33 and its Application for Uric Acid Quantification in Human Serum. 38
25981580 2015
186
Enhancement of a novel extracellular uricase production by media optimization and partial purification by aqueous three-phase system. 38
25674929 2015
187
Hyperuricemia, urate deposition and the association with hypertension. 38
26414732 2015
188
[Hyperuricemia and cardiovascular diseases: from phylogenesys to patogenetic mechanisms]. 38
26005870 2015
189
A cytosolic thioredoxin acts as a molecular chaperone for peroxisome matrix proteins as well as antioxidant in peroxisome. 38
26013260 2015
190
Engineering Human Urate Oxidase: Towards Reactivating It as an Important Therapeutic Enzyme. 38
26343133 2015
191
Optimization of pH values to formulate the bireagent kit for serum uric acid assay. 38
24673428 2015
192
Low circulating insulin-like growth factor-1 levels are associated with high serum uric acid in nondiabetic adult subjects. 38
25149895 2014
193
Poly(brilliant green) and poly(thionine) modified carbon nanotube coated carbon film electrodes for glucose and uric acid biosensors. 38
25159399 2014
194
Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase. 38
25314114 2014
195
[Anti-hyperuricemia effect and mechanism of polydatin in mice]. 38
25920206 2014
196
Infusion-related reactions with pegloticase, a recombinant uricase for the treatment of chronic gout refractory to conventional therapy. 38
25417679 2014
197
Isolation of a novel uric-acid-degrading microbe Comamonas sp. BT UA and rapid biosensing of uric acid from extracted uricase enzyme. 38
25431410 2014
198
Comparison of modification of a bacterial uricase with N-hydroxysuccinimide esters of succinate and carbonate of monomethoxyl poly(ethylene glycol). 38
24512141 2014
199
Pharmacodynamic analysis of intravenous recombinant urate oxidase using an indirect pharmacological response model in healthy subjects. 38
25283504 2014
200
Enhancing performance of uricase using multiwalled carbon nanotube doped polyaniline. 38
24928549 2014
201
Construction of an uricase nanoparticles modified au electrode for amperometric determination of uric acid. 38
25141984 2014
202
Reagentless uric acid biosensor based on Ni microdiscs-loaded NiO thin film matrix. 38
25046556 2014
203
Characterization of purine catabolic pathway genes in coelacanths. 38
23733620 2014
204
Confined multiple enzymatic (cascade) reactions within poly(dopamine)-based capsosomes. 38
24968314 2014
205
Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids. 38
24755741 2014
206
Consumption of strawberries on a daily basis increases the non-urate 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity of fasting plasma in healthy subjects. 38
25120279 2014
207
A general strategy to prepare homogeneous and reagentless GO/lucigenin&enzyme biosensors for detection of small biomolecules. 38
24549137 2014
208
Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. 38
24652948 2014
209
Pegloticase. An excessively dangerous and inadequately evaluated hypouricaemic drug. 38
25162087 2014
210
Comparison of two plasma urate assays in patients receiving vitamin C supplementation. 38
24798153 2014
211
An amperometric uric acid biosensor based on chitosan-carbon nanotubes electrospun nanofiber on silver nanoparticles. 38
24718436 2014
212
Inducing electrocatalytic functionality in ZnO thin film by N doping to realize a third generation uric acid biosensor. 38
24362079 2014
213
Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. 38
24663677 2014
214
Very fast electrophoretic determination of creatinine and uric acid in human urine using a combination of two capillaries with different internal diameters. 38
24114779 2014
215
Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients. 38
24602182 2014
216
Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout. 38
24588936 2014
217
Glassy carbon electrodes sequentially modified by cysteamine-capped gold nanoparticles and poly(amidoamine) dendrimers generation 4.5 for detecting uric acid in human serum without ascorbic acid interference. 38
24491759 2014
218
Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease. 38
23584883 2014
219
Effect of processing parameters for electrocatalytic properties of SnO(2) thin film matrix for uric acid biosensor. 38
24396852 2014
220
Real-time in vivo uric acid biosensor system for biophysical monitoring of birds. 38
24326318 2014
221
Determination of uric acid level by polyaniline and poly (allylamine): Based biosensor. 38
24696812 2014
222
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD. 38
24643131 2014
223
Activity and stability of uricase from Lactobacillus plantarum immobilizated on natural zeolite for uric acid biosensor. 38
24783814 2014
224
Covalent immobilization of uricase inside a plastic vial for uric acid determination in serum and urine. 38
24717661 2014
225
Isolation, screening and production studies of uricase producing bacteria from poultry sources. 38
24279683 2014
226
Preparing a new biosensor for hypoxanthine determination by immobilization of xanthine oxidase and uricase in polypyrrole-polyvinyl sulphonate film. 38
23305069 2013
227
Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP). 38
23665398 2013
228
Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice. 38
23804456 2013
229
Nitrogen-doped zinc oxide thin films biosensor for determination of uric acid. 38
23730688 2013
230
New developments in gout. 38
23466959 2013
231
Enzyme-entrapped mesoporous silica for treatment of uric acid disorders. 38
23802423 2013
232
Disposable biosensor based on cathodic electrochemiluminescence of tris(2,2-bipyridine)ruthenium(II) for uric acid determination. 38
23498698 2013
233
Comparison of activity indexes for recognizing enzyme mutants of higher activity with uricase as model. 38
23594729 2013
234
Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. 38
22648289 2013
235
Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology. 38
23401356 2013
236
Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. 38
23303409 2013
237
Novel drug discovery strategies for gout. 38
23231400 2013
238
Enzyme-modified indium tin oxide microelectrode array-based electrochemical uric acid biosensor. 38
29470786 2013
239
Classification of difference between inhibition constants of an inhibitor to facilitate identifying the inhibition type. 38
22224402 2013
240
New therapies for gout. 38
23327525 2013
241
Associations of serum uric acid and SLC2A9 variant with depressive and anxiety disorders: a population-based study. 38
24204615 2013
242
Oral findings in end-stage renal disease. 38
24566019 2013
243
Is there association between uric acid and inflammation in hemodialysis patients? 38
23394103 2013
244
Thermal inactivation of uricase (urate oxidase): mechanism and effects of additives. 38
23237426 2013
245
PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation. 38
23215688 2013
246
Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents. 38
22931049 2012
247
Protection of dopaminergic cells by urate requires its accumulation in astrocytes. 38
22671773 2012
248
Anti-inflammatory and immunomodulatory effects of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats. 38
22910180 2012
249
CuO thin film based uric acid biosensor with enhanced response characteristics. 38
22647533 2012
250
Uricase from Bacillus fastidious loaded in alkaline enzymosomes: enhanced biochemical and pharmacological characteristics in hypouricemic rats. 38
22705639 2012
251
Pegloticase and the patient with treatment-failure gout. 38
23121270 2012
252
Development of a sandwich format, amperometric screen-printed uric acid biosensor for urine analysis. 38
22705172 2012
253
Gold nanoparticle-enzyme conjugates based FRET for highly sensitive determination of hydrogen peroxide, glucose and uric acid using tyramide reaction. 38
22745932 2012
254
Pegloticase for treating refractory chronic gout. 38
22844655 2012
255
Characterization, efficacy, pharmacokinetics, and biodistribution of 5kDa mPEG modified tetrameric canine uricase variant. 38
22503989 2012
256
Comparative structural modeling and docking studies of uricase: possible implication in enzyme supplementation therapy for hyperuricemic disorders. 38
22537975 2012
257
Supplementation of poultry feeds with dietary zinc and other minerals and compounds to mitigate nitrogen emissions--a review. 38
22215283 2012
258
Structure-based characterization of canine-human chimeric uricases and its evolutionary implications. 38
22481018 2012
259
Immbolization of uricase enzyme in Langmuir and Langmuir-Blodgett films of fatty acids: possible use as a uric acid sensor. 38
21875709 2012
260
[Gout: an overview of available urate lowering therapies]. 38
22655581 2012
261
[The hyperiricosuria as an indicator of derangement of biologic functions of endoecology and adaptation, biologic reactions of excretion, inflammation and arterial tension]. 38
22768707 2012
262
Genome-wide analysis of the response of Dickeya dadantii 3937 to plant antimicrobial peptides. 38
22204647 2012
263
Effect of lovastatin therapy and withdrawal on serum uric acid level in people with type 2 diabetic nephropathy. 38
22444196 2012
264
Up-to-date management of gout. 38
22301867 2012
265
Pegloticase: a novel agent for treatment-refractory gout. 38
22395256 2012
266
Role of the methoxy group in immune responses to mPEG-protein conjugates. 38
22332808 2012
267
Uricases as therapeutic agents to treat refractory gout: Current states and future directions. 38
22665944 2012
268
Recent advances in renal urate transport: characterization of candidate transporters indicated by genome-wide association studies. 38
22038265 2012
269
The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus. 38
22301198 2012
270
Multicenter uric acid biosensor based on tetrapod-shaped ZnO nanostructures. 38
22524012 2012
271
Critical appraisal of the role of pegloticase in the management of gout. 38
27790013 2012
272
Reproductive factors and serum uric acid levels in females from the general population: the KORA F4 study. 38
22427861 2012
273
Uric acid is more strongly associated with impaired glucose regulation in women than in men from the general population: the KORA F4-Study. 38
22615932 2012
274
The influence of oxonate-induced hyperuricemia and allopurinol on behavioral reactions of random-bred mice. 38
23023694 2012
275
[New and emerging drugs for uric arthritis]. 38
23745467 2012
276
Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations. 38
23235493 2012
277
Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury. 38
23226314 2012
278
Uricase-adsorbed carbon-felt reactor coupled with a peroxidase-modified carbon-felt-based H2O2 detector for highly sensitive amperometric flow determination of uric acid. 38
21906900 2012
279
Construction of amperometric uric acid biosensor based on uricase immobilized on PBNPs/cMWCNT/PANI/Au composite. 38
22020190 2012
280
Improved biological properties and hypouricemic effects of uricase from Candida utilis loaded in novel alkaline enzymosomes. 38
22915844 2012
281
Impact of large aggregated uricases and PEG diol on accelerated blood clearance of PEGylated canine uricase. 38
22745806 2012
282
A potentiometric indirect uric acid sensor based on ZnO nanoflakes and immobilized uricase. 38
22736977 2012
283
Highly sensitive and selective uric acid biosensor based on RF sputtered NiO thin film. 38
21996325 2011
284
Apical voltage-driven urate efflux transporter NPT4 in renal proximal tubule. 38
22132991 2011
285
Pegloticase: in treatment-refractory chronic gout. 38
22035516 2011
286
High-yield expression, purification, characterization, and structure determination of tag-free Candida utilis uricase. 38
21573940 2011
287
Association of serum uric acid with incident atrial fibrillation (from the Atherosclerosis Risk in Communities [ARIC] study). 38
21855838 2011
288
Egg yolk and serum antibody titers of broiler breeder hens immunized with uricase and or urease. 38
21933996 2011
289
Designing and engineering of a site-specific incorporation of a keto group in uricase. 38
21585711 2011
290
Long-term adherence to the Mediterranean diet reduces the prevalence of hyperuricaemia in elderly individuals, without known cardiovascular disease: the Ikaria study. 38
21724344 2011
291
[Current management of gout]. 38
22525631 2011
292
Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations. 38
22000645 2011
293
Disposable luminol copolymer-based biosensor for uric acid in urine. 38
21839206 2011
294
Urate transporters: an evolving field. 38
22000646 2011
295
[New therapeutic options for gout]. 38
21684104 2011
296
Biochemical measurement of neonatal hypoxia. 38
21897351 2011
297
Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials. 38
21846852 2011
298
Simple and rapid method for the determination of uric acid-independent antioxidant capacity. 38
21849933 2011
299
Difficult-to-treat gouty arthritis: a disease warranting better management. 38
21812506 2011
300
An amperometric uric acid biosensor based on multiwalled carbon nanotube-gold nanoparticle composite. 38
21315682 2011
301
Immobilization of uricase enzyme on self-assembled gold nanoparticles for application in uric acid biosensor. 38
21770094 2011
302
Polyoxazoline: chemistry, properties, and applications in drug delivery. 38
21452890 2011
303
Construction of uricase-overproducing strains of Hansenula polymorpha and its application as biological recognition element in microbial urate biosensor. 38
21612631 2011
304
Nano-sized platinum as a mimic of uricase catalyzing the oxidative degradation of uric acid. 38
21359394 2011
305
MarR homologs with urate-binding signature. 38
21432936 2011
306
Reversible immobilization of uricase on conductive polyaniline brushes grafted on polyacrylonitrile film. 38
20652599 2011
307
Production and partial characterization of uric acid degrading enzyme from new source Saccharopolyspora sp. PNR11. 38
21870646 2011
308
Conductimetric biosensor for the detection of uric Acid by immobilization uricase on nata de coco membrane-pt electrode. 38
21792276 2011
309
Gender-specific association of serum uric acid with metabolic syndrome and its components in juvenile obesity. 38
20961193 2011
310
MicroRNA expression patterns of the kidney in hyperuricemia mice treated with Xiezhuo Chubi Decoction. 38
21258895 2011
311
Gout therapeutics: new drugs for an old disease. 38
20719377 2011
312
Estimation of serum uric acid in cases of hyperuricaemia and gout. 38
22335090 2011
313
Influence of physical activity intensity and aerobic fitness on the anthropometric index and serum uric acid concentration in people with obesity. 38
21963729 2011
314
Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study. 38
21625475 2011
315
Adenosine A2A receptors and uric acid mediate protective effects of inosine against TNBS-induced colitis in rats. 38
20868668 2010
316
One-chip biosensor for simultaneous disease marker/calibration substance measurement in human urine by electrochemical surface plasmon resonance method. 38
20888212 2010
317
Fluorometric determination of uric acid in bovine milk. 38
20822564 2010
318
Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. 38
20810651 2010
319
A new practical system for evaluating the pharmacological properties of uricase as a potential drug for hyperuricemia. 38
21116779 2010
320
Uric acid and evolution. 38
20627967 2010
321
New advances in the treatment of gout: review of pegloticase. 38
21127695 2010
322
Urate is a ligand for the transcriptional regulator PecS. 38
20678501 2010
323
An amperomertic uric acid biosensor based on immobilization of uricase onto polyaniline-multiwalled carbon nanotube composite film. 38
20367113 2010
324
[Plasma antioxidant activity--a test for impaired biological functions of endoecology, exotrophy, and inflammation reactions]. 38
20799406 2010
325
Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese men. 38
20158446 2010
326
Effect of plasma uric acid on pharmacokinetics of cyclosporine A in living-related renal transplant recipients and pharmacokinetic study in rats with experimental hyperuricaemia. 38
20831533 2010
327
Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand. 38
20516624 2010
328
Uric acid does not affect the acetylcholine-induced relaxation of aorta from normotensive and deoxycorticosterone acetate-salt hypertensive rats. 38
20215410 2010
329
Identification of uricase as a potential target of plant thioredoxin: Implication in the regulation of nodule development. 38
20470756 2010
330
Association of cognitive function with serum uric acid level among Chinese nonagenarians and centenarians. 38
20080169 2010
331
Serum uric acid in top-level alpine skiers over four consecutive competitive seasons. 38
20100473 2010
332
Low-potential detection of endogenous and physiological uric acid at uricase-thionine-single-walled carbon nanotube modified electrodes. 38
20163156 2010
333
Biochemical and biopharmaceutical properties of PEGylated uricase. 38
19969053 2010
334
Construction of uric acid biosensor based on biomimetic titanate nanotubes. 38
20352728 2010
335
Effects of modification of amino groups with poly(ethylene glycol) on a recombinant uricase from Bacillus fastidiosus. 38
20530883 2010
336
Preparation and characterization of lipid vesicles containing uricase. 38
22747073 2010
337
Characterization, stabilization and activity of uricase loaded in lipid vesicles. 38
19782743 2010
338
Update on gout: new therapeutic strategies and options. 38
20046204 2010
339
Theodore E. Woodward award. The evolution of obesity: insights from the mid-Miocene. 38
20697570 2010
340
Exercise-induced changes in renal URAT1 activity and expression in rats. 38
20662700 2010
341
[Gout and comorbidities associated with hyperuricemia]. 38
21365938 2010
342
New and improved strategies for the treatment of gout. 38
21694941 2010
343
Recent insights into the pathogenesis of hyperuricaemia and gout. 38
19808794 2009
344
Reversible inactivation of an intracellular uricase from Bacillus fastidiosus via dissociation of homotetramer into homodimers in solutions of low ionic strength. 38
19734651 2009
345
Fabrication of dissolved O2 metric uric acid biosensor using uricase epoxy resin biocomposite membrane. 38
19591705 2009
346
Uric acid attenuates trophoblast invasion and integration into endothelial cell monolayers. 38
19535510 2009
347
Highly sensitive and selective uric acid biosensor based on direct electron transfer of hemoglobin-encapsulated chitosan-modified glassy carbon electrode. 38
19667479 2009
348
Urinary uric acid : creatinine ratios in healthy Turkish children. 38
19674364 2009
349
Electrochemical detection for paper-based microfluidics. 38
19485415 2009
350
Mechanism for attenuation of DNA binding by MarR family transcriptional regulators by small molecule ligands. 38
19501097 2009
351
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. 38
19218193 2009
352
A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout. 38
19296886 2009
353
Purine nucleotide catabolism in rat liver. Certain preliminary aspects of uricase reaction. 38
19333858 2009
354
Update on emerging urate-lowering therapies. 38
19339925 2009
355
Uric acid is a mediator of the Plasmodium falciparum-induced inflammatory response. 38
19381275 2009
356
Strengthening intersubunit hydrogen bonds for enhanced stability of recombinant urate oxidase from Aspergillus flavus: molecular simulations and experimental validation. 38
19088989 2009
357
Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry. 38
19081307 2009
358
Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society? 38
18649082 2009
359
The determination of uric acid in urine--forgotten problems rediscovered in an external quality assessment scheme. 38
20099570 2009
360
An integration strategy to estimate the initial rates of enzyme reactions with much expanded linear ranges using uricases as models. 38
19046674 2009
361
Fully reversible optical biosensors for uric acid using oxygen transduction. 38
18815025 2008
362
Serum uric acid levels correlate with plasma hydrogen peroxide and protein carbonyl levels in preeclampsia. 38
18802427 2008
363
Uric acid: bystander or culprit in hypertension and progressive renal disease? 38
18854744 2008
364
Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. 38
18701632 2008
365
Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: results of a phase II randomized study. 38
18759308 2008
366
An Amperometric Biosensor for Uric Acid Determination Prepared From Uricase Immobilized in Polyaniline-Polypyrrole Film. 38
27873826 2008
367
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. 38
18728266 2008
368
Uricase production by a recombinant Hansenula polymorpha strain harboring Candida utilis uricase gene. 38
18437374 2008
369
An electrochemiluminescent biosensor for uric acid based on the electrochemiluminescence of bis-[3,4,6-trichloro-2-(pentyloxycarbonyl)-phenyl] oxalate on an ITO electrode modified by an electropolymerized nickel phthalocyanine film. 38
18493682 2008
370
[Molecular mechanisms of urate transport in renal tubules: localization and function of urate transporters]. 38
18409511 2008
371
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. 38
18362170 2008
372
Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia. 38
18048425 2008
373
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. 38
18327257 2008
374
Pegloticase, a polyethylene glycol conjugate of uricase for the potential intravenous treatment of gout. 38
18393109 2008
375
[New antihyperuricemic medicine: febuxostat, Puricase, etc]. 38
18409528 2008
376
[How do we set the standard value of serum uric acid levels?]. 38
18409522 2008
377
Production of a thermostable uricase by a novel Bacillus thermocatenulatus strain. 38
17395458 2008
378
Refractory gout: what is it and what to do about it? 38
18349751 2008
379
Developments in the scientific and clinical understanding of gout. 38
18947374 2008
380
Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice. 38
18306458 2008
381
The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease. 38
18331782 2008
382
The impact of PEGylation on biological therapies. 38
18778113 2008
383
Prevention of oxidative stress to the retina by pyruvate. A preliminary report. 38
18497529 2008
384
PEG-uricase in the management of treatment-resistant gout and hyperuricemia. 38
17826865 2008
385
Uric acid determination using uricase and the autotransducer molecular absorption properties of peroxidase. 38
18190810 2008
386
Update on gout: pathophysiology and potential treatments. 38
18173979 2007
387
Assessment of outcome in clinical trials of gout--a review of current measures. 38
17650521 2007
388
Mercaptoethylpyrazine promoted electrochemistry of redox protein and amperometric biosensing of uric acid. 38
17719217 2007
389
Learning how and when to employ uricase as bridge therapy in refractory gout. 38
17924606 2007
390
Morphine enhances purine nucleotide catabolism in vivo and in vitro. 38
17640470 2007
391
Tumor lysis syndrome. 38
17525897 2007
392
Uricase and other novel agents for the management of patients with treatment-failure gout. 38
17531181 2007
393
Improved performance of polyaniline-uricase biosensor. 38
17560380 2007
394
Uric acid heralds ischemic tissue injury to mobilize endothelial progenitor cells. 38
17409313 2007
395
Dehydrogenase based reagentless biosensor for monitoring phenylketonuria. 38
17029777 2007
396
Emerging therapies in the long-term management of hyperuricaemia and gout. 38
17388867 2007
397
Therapeutic advances in gout. 38
17278926 2007
398
Development and analytical application of an uric acid biosensor using an uricase-immobilized eggshell membrane. 38
17023154 2007
399
Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout. 38
17328081 2007
400
Immobilization of uricase within polystyrene using polymaleimidostyrene as a stabilizer and its application to uric acid sensor. 38
17386751 2007
401
Hyperuricemia and gout: new insights into pathogenesis and treatment. 38
17922673 2007
402
Immobilization of uricase upon polypyrrole-ferrocenium film. 38
18097787 2007
403
The endogenous danger signal uric Acid augments contact hypersensitivity responses in mice. 38
17643063 2007
404
Enzymatic assay of allantoin in serum using allantoinase and allantoate amidohydrolase. 38
17081493 2006
405
Serum uric acid is a determinant of metabolic syndrome in a population-based study. 38
17027827 2006
406
An amperometric uric acid biosensor based on modified Ir-C electrode. 38
16908130 2006
407
Mouse transthyretin-related protein is a hydrolase which degrades 5-hydroxyisourate, the end product of the uricase reaction. 38
17085964 2006
408
High-level expression, purification, and characterization of non-tagged Aspergillus flavus urate oxidase in Escherichia coli. 38
16545578 2006
409
Rasburicase treatment in severe tophaceous gout: a novel therapeutic option. 38
16247589 2006
410
Characterization of a uricase from Bacillus fastidious A.T.C.C. 26904 and its application to serum uric acid assay by a patented kinetic uricase method. 38
16689679 2006
411
Uric acid recycling in the shield bug, Parastrachia japonensis (Hemiptera: Parastrachiidae), during diapause. 38
16797581 2006
412
Preliminary investigations on a new disposable potentiometric biosensor for uric acid. 38
16830944 2006
413
Advances in the management of gout and hyperuricaemia. 38
16882587 2006
414
Evaluation of a kinetic uricase method for serum uric acid assay by predicting background absorbance of uricase reaction solution with an integrated method. 38
16691645 2006
415
The crystal structure of the transcriptional regulator HucR from Deinococcus radiodurans reveals a repressor preconfigured for DNA binding. 38
16750221 2006
416
New developments in clinically relevant mechanisms and treatment of hyperuricemia. 38
16901081 2006
417
Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family. 38
16782815 2006
418
[The hydrogen peroxide paradox]. 38
16784144 2006
419
The occurrence and nature of electrochemical activity in milk from a herd of dairy cows. 38
16433970 2006
420
A clinical assessment of direct electrochemical urate measurements. 38
18970486 2006
421
ZnS quantum dots derived a reagentless uric acid biosensor. 38
18970471 2006
422
Newer therapeutic approaches: gout. 38
16504833 2006
423
Combined approach to the analysis of recombinant protein drugs using hollow-fiber flow field-flow fractionation, mass spectrometry, and chemiluminescence detection. 38
16478098 2006
424
[Gout]. 38
16463802 2006
425
Allopurinol/uricase and ibuprofen enhance engraftment of cardiomyocyte-enriched human embryonic stem cells and improve cardiac function following myocardial injury. 38
16337396 2006
426
Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase. 38
16356199 2006
427
An amperometric biosensor for uric acid determination prepared from uricase immobilized in polypyrrole film. 38
16809136 2006
428
[Role of uric acid in hypertension and in the progression of chronic renal disease]. 38
16521070 2006
429
Purification, and properties of a bovine uricase. 38
16712512 2006
430
Pathophysiology, clinical presentation and treatment of gout. 38
16956303 2006
431
Salivary cortisol-marker of stress response to different dental treatment. 38
17236287 2006
432
Plasma antioxidant capacity among middle-aged men: the contribution of uric acid. 38
16714252 2006
433
Gout in 2006: the perfect storm. 38
17121496 2006
434
Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics. 38
16820043 2006
435
Uric acid--a uremic toxin? 38
16361844 2006
436
Purine catabolism in advanced carotid artery plaque. 38
17065109 2006
437
Isolation of glyoxysomes from pumpkin cotyledons. 38
18228487 2006
438
Hypouricemic effects of acacetin and 4,5-o-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats. 38
16327155 2005
439
[Multifactorial disorder: molecular and evolutionary insights of uric acid nephrolithiasis]. 38
16518303 2005
440
Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. 38
16098976 2005
441
Nitrogen-responsive genes are differentially regulated in planta during Fusarium oxyspsorum f. sp. lycopersici infection. 38
20565671 2005
442
Negative cooperativity of uric acid binding to the transcriptional regulator HucR from Deinococcus radiodurans. 38
15967460 2005
443
Renal urate handling: clinical relevance of recent advances. 38
15919000 2005
444
Hyperuricemia induces endothelial dysfunction. 38
15840020 2005
445
Serum uric acid levels and leukocyte nitric oxide production in multiple sclerosis patients outside relapses. 38
15792819 2005
446
An increase of uricogenesis in the Kuruma shrimp Marsupenaeus japonicus under nitrite stress. 38
15776415 2005
447
[Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats]. 38
15738631 2005
448
Urate oxidase from Aspergillus flavus: new crystal-packing contacts in relation to the content of the active site. 38
15735331 2005
449
Uric acid, evolution and primitive cultures. 38
15660328 2005
450
Hemodynamics of hyperuricemia. 38
15660330 2005
451
Overview of hyperuricaemia and gout. 38
16375732 2005
452
The comparison of the estimation of enzyme kinetic parameters by fitting reaction curve to the integrated Michaelis-Menten rate equations of different predictor variables. 38
15656940 2005
453
Study of carbon nanotube modified biosensors for monitoring uric acid and total cholesterol in blood. 38
17282161 2005
454
Production of the carbonate radical anion during xanthine oxidase turnover in the presence of bicarbonate. 38
15448145 2004
455
HucR, a novel uric acid-responsive member of the MarR family of transcriptional regulators from Deinococcus radiodurans. 38
15448166 2004
456
Simultaneous determination of renal clinical analytes in serum using hydrolase- and oxidase-encapsulated optical array biosensors. 38
15464967 2004
457
EPR spin trapping of a radical intermediate in the urate oxidase reaction. 38
15571216 2004
458
Emergence of Talanin protein associated with human uric acid nephrolithiasis in the Hominidae lineage. 38
15363853 2004
459
[Physiology and biochemistry of uric acid]. 38
15493112 2004
460
In vivo and in vitro degradation of urea and uric acid by encapsulated genetically modified microorganisms. 38
15588404 2004
461
Uric acid promotes tumor immune rejection. 38
15289304 2004
462
Exclusion of galectin 9 as a candidate gene for hyperuricosuria in the Dalmatian dog. 38
15265074 2004
463
Detection of serum uric acid using the optical polymeric enzyme biochip system. 38
15142596 2004
464
Polyaniline-uricase biosensor prepared with template process. 38
15142597 2004
465
Volatiles production and attractiveness to the Mexican fruit fly of Enterobacter agglomerans isolated from apple maggot and Mexican fruit flies. 38
15503523 2004
466
Increase of uricogenesis in the kuruma shrimp Marsupenaeus japonicus reared under hyper-osmotic conditions. 38
15253873 2004
467
Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase. 38
15134605 2004
468
Ureide biosynthesis in legume nodules. 38
14977553 2004
469
Development of an HPLC method with electrochemical detection of femtomoles of 8-oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine in the presence of uric acid. 38
18969435 2004
470
Degradation of low molecular weight uremic solutes by oral delivery of encapsulated enzymes. 38
15171478 2004
471
2,8-Dihydroxyadenine renal stones in a 41-year-old man. 38
15025810 2004
472
Flow-injection assay of catalase activity. 38
15068290 2004
473
Modified colorimetric assay for uricase activity and a screen for mutant Bacillus subtilis uricase genes following StEP mutagenesis. 38
14728678 2004
474
Identification, cloning and expression of Pseudomonas aeruginosa Ps-x putative urate oxidase gene in Escherichia coli. 38
15790071 2004
475
Purification and characterization of extracellular Pseudomonas aeruginosa urate oxidase enzyme. 38
15330267 2004
476
Molecular cloning and expression of uricase gene from Arthrobacter globiformis in Escherichia coli and characterization of the gene product. 38
16233683 2004
477
Peroxynitrite delivery methods for toxicity studies. 38
14727917 2004
478
A reagent less fluorescent sol-gel biosensor for uric acid detection in biological fluids. 38
14596833 2003
479
Amperometric uric acid sensors based on polyelectrolyte multilayer films. 38
18969195 2003
480
Production of an egg yolk antibody specific to microbial uricase and its inhibitory effects on uricase activity. 38
14601732 2003
481
[Urate transporter and renal hypouricemia]. 38
14560659 2003
482
The case for uricase in gout. 38
12744813 2003
483
The epidemiology of hyperuricemia in children of Taiwan aborigines. 38
12672209 2003
484
Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid. 38
12562831 2003
485
The transthyretin-related protein family. 38
12542701 2003
486
Effect of minerals on activity of microbial uricase to reduce ammonia volatilization in poultry manure. 38
12619798 2003
487
Quantification of urinary urate with alkylamine glass-bound uricase and arylamine glass-bound peroxidase. 38
23105367 2003
488
Hyperuricemia causes glomerular hypertrophy in the rat. 38
12373074 2003
489
A role for uric acid in the progression of renal disease. 38
12444207 2002
490
[Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice]. 38
12776538 2002
491
Modified high amylose starch for immobilization of uricase for therapeutic application. 38
12452799 2002
492
Regulation of expression of the Rhizopus oryzae uricase and urease enzymes. 38
12619824 2002
493
Urate produced during hypoxia protects heart proteins from peroxynitrite-mediated protein nitration. 38
12398932 2002
494
Microarray analysis of gene expression in rat hippocampus after chronic ethanol treatment. 38
12462420 2002
495
A colorimetric 96-well microtiter plate assay for the determination of urate oxidase activity and its kinetic parameters. 38
12413448 2002
496
Emergency care: the tumor lysis syndrome. 38
14974215 2002
497
Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies. 38
12233890 2002
498
Chemiluminescence biosensor chip based on a microreactor using carrier air flow for determination of uric acid in human serum. 38
12375839 2002
499
Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. 38
12215479 2002
500
Modulation of gene and protein expression by carbon tetrachloride in the rat liver. 38
12217644 2002
501
Modification of a reactive cysteine explains differences between rasburicase and Uricozyme, a natural Aspergillus flavus uricase. 38
12149119 2002
502
A purification method of the diagnostic enzyme Bacillus uricase using magnetic beads and non-specific protease. 38
12182822 2002
503
Purine metabolizing capability of Enterobacter agglomerans affects volatiles production and attractiveness to Mexican fruit fly. 38
12371809 2002
504
Effect of short-term N(2) deficiency on expression of the ureide pathway in cowpea root nodules. 38
12114575 2002
505
Molecular identification of a renal urate anion exchanger that regulates blood urate levels. 38
12024214 2002
506
Urate oxidase from the rust Puccinia recondita is a heterotetramer with two different-sized monomers. 38
11910495 2002
507
Uric acid is a genuine metabolite of Penicillium cyclopium and stimulates the expression of alkaloid biosynthesis in this fungus. 38
11916664 2002
508
Chemiluminometric sensor for simultaneous determination of L-glutamate and L-lysine with immobilized oxidases in a flow injection system. 38
11922293 2002
509
Host plant nodule parameters associated with nitrogen fixation efficiency in French bean (Phaseolus vulgaris L) cultivars. 38
12635706 2002
510
The analysis of uric acid in urine using microchip capillary electrophoresis with electrochemical detection. 38
11891710 2002
511
Morphologic phenotyping with MR microscopy: the visible mouse. 38
11867802 2002
512
Bioconversion of poultry wastes. I--Factors influencing the assay and productivity of crude uricase by three uricolytic filamentous fungi. 38
12512254 2002
513
Bioconversion of poultry wastes I-factors influencing the assay and productivity of crude uricase by three uricolytic filamentous fungi. 38
11837392 2002
514
Temperature induced alterations in the liver of wall lizard (Hemidactylus frenatus): morphological and biochemical parameters. 38
12475563 2002
515
Estimation of allantoin flux using continuous infusion of [14C]allantoin: sensitivity to plasma loading with unlabelled allantoin. 38
11749678 2001
516
Expression of the urate transporter/channel is developmentally regulated in human kidneys. 38
11592946 2001
517
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. 38
11711505 2001
518
Flow-through chemiluminescence sensor using immobilized oxidases for the selective determination of L-glutamate in a flow-injection system. 38
11708095 2001
519
Immunological properties of uricase conjugated to neutral soluble polymers. 38
11459455 2001
520
Direct determination of uric acid in serum by a fluorometric-enzymatic method based on uricase. 38
18968307 2001
521
Functional analysis of 14 genes that constitute the purine catabolic pathway in Bacillus subtilis and evidence for a novel regulon controlled by the PucR transcription activator. 38
11344136 2001
522
Pathways for urea production during early life of an air-breathing teleost, the African catfish Clarias gariepinus Burchell. 38
11441057 2001
523
Voltammetric biosensors for the determination of formate and glucose-6-phosphate based on the measurement of dehydrogenase-generated NADH and NADPH. 38
11340000 2001
524
The cloning, genomic structure, localization, and expression of human deoxyribonuclease IIbeta. 38
11376952 2001
525
Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase. 38
11316859 2001
526
Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors. 38
11294382 2001
527
Hyperuricemia exacerbates chronic cyclosporine nephropathy. 38
11349724 2001
528
Purine nucleotide catabolism in rat liver: labelling of uric acid and allantoin after treatment with oxonic acid and allopurinol. 38
11228097 2001
529
Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. 38
11474184 2001
530
[Cloning and expression of urate oxidase and its application in serum uric acid analysis]. 38
11330191 2001
531
Potassium citrate administration ameliorates tubulointerstitial lesions in rats with uric acid nephropathy. 38
11200869 2001
532
Structural and expression analysis of uricase mRNA from Lotus japonicus. 38
11043477 2000
533
Fully-automated spectrophotometric method for measurement of antioxidant activity of catalase. 38
11124337 2000
534
Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathy. 38
11126199 2000
535
Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization. 38
11054555 2000
536
Effect of tea and coffee consumption on serum uric acid levels by liquid-chromatographic and uricase methods. 38
10903352 2000
537
Evolutionary studies on uricases of fungal endosymbionts of aphids and planthoppers. 38
11029071 2000
538
Xenopus allantoicase: molecular cloning, enzymatic activity and developmental expression. 38
10864446 2000
539
Interaction of hypoxanthine/xanthine oxidase with nitrergic relaxation in the porcine gastric fundus. 38
10807674 2000
540
Therapeutic proteins: a comparison of chemical and biological properties of uricase conjugated to linear or branched poly(ethylene glycol) and poly(N-acryloylmorpholine). 38
10966157 2000
541
Determination of urinary urate with alkylamine glass-bound uricase. 38
10983426 2000
542
Cloning, sequence analysis and expression in Escherichia coli of the gene encoding a uricase from the yeast-like symbiont of the brown planthopper, Nilaparvata lugens. 38
10696593 2000
543
Nonenzymatic elimination of ascorbic acid in clinical samples. 38
10693983 2000
544
Evolution of urate-degrading enzymes in animal peroxisomes. 38
11330038 2000
545
Expression of two uricase (Nodulin-35 genes in a non-ureide type legume, Medicago sativa. 38
10750714 2000
546
A biomimetic phospholipid/alkanethiolate bilayer immobilizing uricase and an electron mediator on an Au electrode for amperometric determination of uric acid. 38
10517148 1999
547
Degradation of overexpressed wild-type and mutant uricase proteins in cultured cells. 38
10449534 1999
548
Biopharmaceutical properties of uricase conjugated to neutral and amphiphilic polymers. 38
10411462 1999
549
'Pseudohypouricosuria' in alcaptonuria: homogentisic acid interference in the measurement of urinary uric acid with the uricase-peroxidase reaction. 38
10456213 1999
550
Nigrostriatal catecholamine metabolism in guinea pigs is altered by purine enzyme inhibition. 38
10442406 1999
551
Xanthine degradation and related enzyme activities in leaves and fruits of two coffea species differing in caffeine catabolism. 38
10552461 1999
552
Uricase-catalyzed oxidation of uric acid using an artificial electron acceptor and fabrication of amperometric uric acid sensors with use of a redox ladder polymer. 38
10361492 1999
553
Functional analysis and molecular modeling of a cloned urate transporter/channel. 38
10227848 1999
554
Discrete analysis of serum uric acid with immobilized uricase and peroxidase. 38
10392568 1999
555
[Biochemical efficacy of homeopathic and electronic preparations of D8 potassium cyanate]. 38
10213876 1999
556
A comparative study on the hypouricemic activity and potency in renal xanthine calculus formation of two xanthine oxidase/xanthine dehydrogenase inhibitors: TEI-6720 and allopurinol in rats. 38
10741381 1999
557
Interference of IgM paraproteins in the Olympus AU800 uric acid assay. 38
9812170 1998
558
Trimethylamine oxide and urea synthesis in rainbow smelt and some other northern fishes. 38
9754528 1998
559
Highly sensitive flow detection of uric acid based on an intermediate regeneration of uricase. 38
10071392 1998
560
Determination of uric acid in scalp hair for non-invasive evaluation of uricemic controls in hyperuricemia. 38
9586580 1998
561
The epidemiology study of hyperuricemia and gout in a community population of Huangpu District in Shanghai. 38
10374422 1998
562
Determination of 15N isotopic enrichment and concentrations of allantoin and uric acid in urine by gas chromatography/mass spectrometry. 38
9487687 1998
563
Characterization of the common bean uricase II and its expression in organs other than nodules. 38
9414545 1997
564
Enzymatic method for assaying uric acid in serum with a new tetrazolium salt produces water-soluble formazan dye. 38
9455611 1997
565
[Determination of uric acid in scalp hair for non-invasive estimation of uricemic control in hyperuricemia]. 38
9396346 1997
566
Immobilization of uricase to gas diffusion carbon felt by electropolymerization of aniline and its application as an enzyme reactor for uric acid sensor. 38
18966880 1997
567
Two distinct uricase II (nodulin 35) genes are differentially expressed in soybean plants. 38
9245835 1997
568
Reference values of common blood chemistry analytes in healthy population of Rawalpindi-Islamabad area. 38
9301167 1997
569
Quantification of urinary uric acid in the presence of thymol and thimerosal by high-performance liquid chromatography. 38
9129322 1997
570
Expression of a gene for uricase II (nodulin-35) in cotyledons of soybean plants. 38
9097481 1997
571
Gout is on the increase in New Zealand. 38
9059136 1997
572
Preparation of a monoclonal antibody against soybean nodule uricase (nod-35), and immunoblot analysis of the expression of nod-35 in tissues of various legumes. 38
9032970 1996
573
Cloning, sequence analysis, and expression in Escherichia coli of the gene encoding the Candida utilis urate oxidase (uricase). 38
8982864 1996
574
[Development of drug delivery systems for macromolecular drugs]. 38
8831257 1996
575
Poly(o-aminophenol)-modified bienzyme carbon paste electrode for the detection of uric acid. 38
18966549 1996
576
Peroxynitrite-mediated formation of free radicals in human plasma: EPR detection of ascorbyl, albumin-thiyl and uric acid-derived free radicals. 38
8615782 1996
577
Construction of catalase deficient Escherichia coli strains for the production of uricase. 38
8901098 1996
578
[Level of uric acid in aqueous and vitreous humor of man]. 38
9026580 1996
579
[Level of uric acid in aqueous humor of patients with cataract]. 38
9026581 1996
580
[Uric acid level in human aqueous and vitreous humor]. 38
9463115 1996
581
[Uric acid level in aqueous humor of patients with cataract]. 38
9463116 1996
582
Nucleotide sequence of the uricase gene from Bacillus sp. TB-90. 38
8907179 1996
583
Characterization of differing effects caused by homeopathically prepared and conventional dilutions using cytochrome P450 2E1 and other enzymes as detection systems. 38
9395660 1996
584
Hydrogen peroxide metabolism during peroxisome proliferation by fenofibrate. 38
8541349 1995
585
High cell density cultivation and high recombinant protein production of Escherichia coli strain expressing uricase. 38
8611749 1995
586
Transcription of the rat liver uricase-encoding gene is regulated via a cis-acting element responsive to cAMP. 38
8566790 1995
587
NO2 reactive absorption substrates in rat pulmonary surface lining fluids. 38
8529914 1995
588
Effect of chronic experimental renal insufficiency on urate metabolism. 38
8589304 1995
589
Morphological and Molecular Characteristics of Host-Conditioned Ineffective Root Nodules in Cowpea. 38
12228592 1995
590
Use of azure-D2 for the measurement of uric acid in serum. 38
8611669 1995
591
Reconstitution of hepatic uricase in planar lipid bilayer reveals a functional organic anion channel. 38
7473683 1995
592
Peroxyoxalate chemiluminescent assay for oxidase activities based on detecting enzymatically formed hydrogen peroxide. 38
7676861 1995
593
Purification and properties of uricase from Candida sp. and its application in uric acid analysis in serum. 38
7785878 1995
594
Biosensor based on chemiluminescence for serum uric acid determination. 38
8679934 1995
595
Expression pattern of uricase II gene during root nodule development in Phaseolus vulgaris. 38
7843336 1995
596
Separation and determination of liver uric acid and allantoin. 38
7704201 1995
597
Chromium toxicity in Neurospora crassa. 38
7798896 1994
598
Factitiously low urate recoveries in control sera with the Beckman Synchron Systems. 38
7809582 1994
599
Novel, reagentless, amperometric biosensor for uric acid based on a chemically modified screen-printed carbon electrode coated with cellulose acetate and uricase. 38
8067535 1994
600
Purification and properties of uricase from Candida sp. and its application in uric acid analysis in serum. 38
8203871 1994
601
A sensitive determination of uric acid in serum using uricase/catalase/formaldehyde dehydrogenase coupled with formate dehydrogenase. 38
8070073 1994
602
Isolation and immunolocalization of a rat renal cortical membrane urate transporter. 38
8120036 1994
603
Preparation of fibre-entrapped enzyme using cellulose acetate-titanium-iso-propoxide composite as gel matrix. 38
7764733 1994
604
Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation. 38
8124580 1994
605
[Spectrophotometric determination of uric acid in serum using a titanium (IV)-porphyrin complex]. 38
8133459 1994
606
Hypouricemic and uricosuric actions of AA-193 in a hyperuricemic rat model. 38
8289669 1994
607
Polymers for delivering peptides and proteins. 38
8160672 1994
608
Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. 38
8243554 1993
609
[The postnatal development of porcine purine catabolism and the effect of the environmental temperature on turnover]. 38
8237173 1993
610
Expression of antisense nodulin-35 RNA in Vigna aconitifolia transgenic root nodules retards peroxisome development and affects nitrogen availability to the plant. 38
8220465 1993
611
Genetic improvements of an industrial strain of Aspergillus flavus for urate oxidase production. 38
7763466 1993
612
High-level production of a peroxisomal enzyme: Aspergillus flavus uricase accumulates intracellularly and is active in Saccharomyces cerevisiae. 38
1452020 1992
613
Red blood cells as an antigen-delivery system. 38
1457052 1992
614
Identification of an amino acid residue involved in the substrate-binding site of rat liver uricase by site-directed mutagenesis. 38
1520291 1992
615
Effects of serum bilirubin on determination of uric acid by the uricase-peroxidase coupled reaction. 38
1320471 1992
616
Quantitative separation of uric acid and allantoin from rat liver tissue. 38
1627585 1992
617
Dissection of Nodule Development by Supplementation of Rhizobium leguminosarum biovar phaseoli Purine Auxotrophs with 4-Aminoimidazole-5-Carboxamide Riboside. 38
16668898 1992
618
Influence of triglycerides and urate on methods for determination of fructosamine. 38
1591869 1992
619
Cloning and expression in Escherichia coli of the gene encoding Aspergillus flavus urate oxidase. 38
1339455 1992
620
Evidence for malonyl-CoA-sensitive carnitine acyl-CoA transferase activity in sarcoplasmic reticulum of canine heart. 38
1625348 1992
621
Colostral antioxidants: separation and characterization of two activities in human colostrum. 38
1573513 1992
622
Adapting the uricase/peroxidase procedure for plasma urate to reduce interference due to haemolysis, icterus or lipaemia. 38
1536532 1992
623
Comparison of uricase-bound and uricase-loaded erythrocytes as bioreactors for uric acid degradation. 38
1295305 1992
624
Tissue distribution of 111In-labeled uricase conjugated with charged dextrans and polyethylene glycol. 38
1725532 1991
625
Use of the o-phenylenediamine fluorescence system in the enzymatic assay of serum uric acid. 38
1806295 1991
626
Uricase-like catalytic activity of ion-exchange resins modified with metalloporphyrins. 38
18965220 1991
627
Anomalously high concentrations of brain extracellular uric acid detected with chronically implanted probes: implications for in vivo sampling techniques. 38
2051164 1991
628
Oxygen regulation of uricase and sucrose synthase synthesis in soybean callus tissue is exerted at the mRNA level. 38
1830495 1991
629
Fructosamine Test-Plus, a modified fructosamine assay evaluated. 38
2015670 1991
630
Induction of biotransformation in the liver of Eel (Anguilla anguilla L.) by sublethal exposure to dinitro-o-cresol: an ultrastructural and biochemical study. 38
2065626 1991
631
Soybean Nodule-Specific Uricase (Nodulin-35) Is Expressed and Assembled into a Functional Tetrameric Holoenzyme in Escherichia coli. 38
16667995 1991
632
Structural analysis of the rat uricase gene and evidence that lysine 164 is involved in the substrate-binding site of the enzyme. 38
1789248 1991
633
Effect of bilirubin on uricase-peroxidase coupled reactions. Implications for urate measurement in clinical samples and external quality assessment schemes. 38
2024944 1991
634
Reperfusion-induced arrhythmias are not prevented by uric acid in the isolated rat heart. 38
1937149 1991
635
Determination of urate in undiluted whole blood by enzyme electrode. 38
1910669 1991
636
Two rabbit uricase mRNAs and their tissue-specific expression. 38
2269363 1990
637
Characterization of liver-specific expression of rat uricase using monoclonal antibodies and cloned cDNAs. 38
2248979 1990
638
Effect of oxygen pressure on synthesis and export of nitrogenous solutes by nodules of cowpea. 38
24197378 1990
639
Molecular characterization of the Drosophila melanogaster urate oxidase gene, an ecdysone-repressible gene expressed only in the malpighian tubules. 38
2118989 1990
640
Uric acid is a major antioxidant in human nasal airway secretions. 38
2217195 1990
641
An improved colorimetric assay for fructosamine. 38
2121089 1990
642
Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol. 38
1702692 1990
643
Organization of rat uricase chromosomal gene differs greatly from that of the corresponding plant gene. 38
2338140 1990
644
The effect of decreasing the concentration of urinary urate on the crystallization of calcium oxalate in undiluted human urine. 38
2329597 1990
645
An enzymatic assay for the colorimetric and fluorimetric determination of uric acid in sera. 38
2360868 1990
646
[Significance of blood uric acid determination. Review of the literature]. 38
2195627 1990
647
[Electron microscopic morphometric studies of the development of peroxisomes in healthy piglets during the first 4 weeks of life]. 38
2114713 1990
648
Purification of nodule-specific uricase from soybean by arginine-sepharose affinity chromatography. 38
2367346 1990
649
[Clinical laboratory application of HPLC]. 38
2308225 1990
650
Excretion of purine derivatives by ruminants: endogenous excretion, differences between cattle and sheep. 38
2317473 1990
651
[A new fructosamine test--as a routine parameter in the control of diabetes]. 38
2181784 1990
652
Purification of microbial uricase. 38
2625463 1989
653
Cloning of rabbit uricase cDNA reveals a conserved carboxy-terminal tripeptide in three species. 38
2719958 1989
654
An enzymic assay for uric acid in serum and urine compared with HPLC. 38
2708944 1989
655
Degradation of uric acid in fish liver peroxisomes. Intraperoxisomal localization of hepatic allantoicase and purification of its peroxisomal membrane-bound form. 38
2492531 1989
656
Nonenzymatic stopped-flow fluorimetric method for direct determination of uric acid in serum and urine. 38
2914366 1989
657
[Culture conditions for uricase formation of Candida utilis]. 38
2800538 1989
658
A radiochemical-high-performance liquid chromatographic assay for urate oxidase in human plasma. 38
2742121 1989
659
[A recommended method for determination of uric acid in serum]. 38
2782673 1989
660
Sequence analysis of rat liver uricase-cDNA and the possible presence of the homologous cDNA sequences in chicken embryo. 38
2624231 1989
661
Comparative immunology of mammalian uricase using anti-hog liver uricase. 38
2495886 1989
662
Liver uricase in Camelus dromedarius: purification and properties. 38
2620492 1989
663
Morphological and functional modifications of rat liver peroxisomal subpopulations during cold exposure. 38
2721643 1989
664
Effects of 3,5,3'-triiodothyronine (T3) on rat liver peroxisomal compartment during cold exposure. 38
2721644 1989
665
Uricase protein sequences: conserved during vertebrate evolution but absent in humans. 38
3192041 1988
666
Cloning and sequence analysis of cDNA for rat liver uricase. 38
3182808 1988
667
Selective induction of peroxisomal enzymes by the hypolipidemic drug bezafibrate. Detection of modulations by automatic image analysis in conjunction with immunoelectron microscopy and immunoblotting. 38
2903052 1988
668
Use of polyethylene glycol-modified uricase (PEG-uricase) to treat hyperuricemia in a patient with non-Hodgkin lymphoma. 38
3289428 1988
669
Nucleotide sequence of cDNA and predicted amino acid sequence of rat liver uricase. 38
3267221 1988
670
Localization of urate oxidase in the crystalline cores of rat liver peroxisomes by immunocytochemistry and immunoblotting. 38
3346536 1988
671
Interference of the chemotherapeutic agent etoposide with the direct phosphotungstic acid method for uric acid. 38
3479271 1987
672
Expression of nodule-specific genes in Phaseolus vulgaris L. 38
24277190 1987
673
Interstitial ascorbate in turtle brain is modulated by release and extracellular volume change. 38
3625202 1987
674
A cytochemical study of the livers of rats treated with diethylnitrosamine/phenobarbital, with benzidine/phenobarbital, with phenobarbital, or with clofibrate. 38
2823419 1987
675
Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. 38
3689345 1987
676
Cellular compartmentation of ureide biogenesis in root nodules of cowpea (Vigna unguiculata (L.) Walp.). 38
24225867 1987
677
Appearance of purine-catabolizing enzymes in fix and fix root nodules on soybean and effect of oxygen on the expression of the enzymes in callus tissue. 38
16665719 1987
678
Evidence for the transport function of uricase, an oxidative enzyme. 38
3661720 1987
679
Purification, cDNA Cloning, and Developmental Expression of the Nodule-Specific Uricase from Phaseolus vulgaris L. 38
16665575 1987
680
Deproteinizing methods evaluated for determination of uric acid in serum by reversed-phase liquid chromatography with ultraviolet detection. 38
3608161 1987
681
Biogenesis of peroxisomes in regenerating rat liver. I. Sequential changes of catalase and urate oxidase detected by ultrastructural cytochemistry. 38
3622522 1987
682
Induction and de novo synthesis of uricase, a nitrogen-regulated enzyme in Neurospora crassa. 38
2952636 1987
683
Does morphine enhance the release of 5-hydroxytryptamine in the rat spinal cord? An in vivo differential pulse voltammetry study. 38
2440518 1987
684
Transient response of encapsulated enzymes in hollow-fiber reactor. 38
18576482 1987
685
[Circadian rhythm of uric acid levels of the serum in gout]. 38
3589998 1987
686
Comparison of intraperoxisomal localization form and properties of amphibian (Rana catesbeiana) uricase with those of other animal uricases. 38
3493879 1987
687
Insoluble uricase in liver peroxisomes of Old World monkeys. 38
3427896 1987
688
Postnatal development of hepatic uricase and peroxisomes in baby pigs. 38
3427926 1987
689
Spectrophotometric assay of xanthine oxidase with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen. 38
3802544 1987
690
Generation of allantoin from the oxidation of urate by cytochrome c and its possible role in Reye's syndrome. 38
3028263 1987
691
Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation. 38
3026367 1986
692
2,8-Dihydroxyadenine lithiasis. 38
3780004 1986
693
Evaluation of the spectrophotometric assay of guanase with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen. 38
3746203 1986
694
Genetic locus in Rhizobium japonicum (fredii) affecting soybean root nodule differentiation. 38
3009416 1986
695
Immunogold localization of nodule-specific uricase in developing soybean root nodules. 38
24240357 1986
696
Enzymes of ammonia assimilation and ureide biosynthesis in soybean nodules: effect of nitrate. 38
16664678 1986
697
Ultrastructural cytochemical localization of uricase in peroxisomes of rat liver. 38
3080517 1986
698
Immobilization of uricase on protamine bound to glass beads and its application to determination of uric acid. 38
3963371 1986
699
[An enzymatic color test for determining uric acid by the uricase-phenol-aminoantipyrine method]. 38
3727742 1986
700
H2O2 formation during nucleotide degradation in the hypoxic rat liver: a quantitative approach. 38
2850267 1986
701
Ocular hyperuricosis in the rabbit following hyperuricemia and topical epinephrine. 38
3503097 1986
702
Expression of nodule-specific uricase in soybean callus tissue is regulated by oxygen. 38
16453663 1986
703
Comments on the uricase/peroxidase--phenol--4--aminoantipyrine reaction. 38
3000645 1986
704
Amber nonsense mutations in regulatory and structural genes of the nitrogen control circuit of Neurospora crassa. 38
2965995 1986
705
Biphasic contraction of isolated guinea pig tracheal chains by superoxide radical. 38
2995255 1985
706
Primary structure of the soybean nodulin-35 gene encoding uricase II localized in the peroxisomes of uninfected cells of nodules. 38
16593585 1985
707
Inhibition of uricase by pyrimidine and purine drugs. 38
4042322 1985
708
Acute monoarthritis associated with lipid liquid crystals. 38
2992399 1985
709
Role of uricase in the triggering of germination of Bacillus fastidiosus spores. 38
4038258 1985
710
In vivo voltammetric evidence of production of uric acid by rat caudate. 38
4005552 1985
711
The all2 gene is required for the induction of the purine deamination pathway in Schizosaccharomyces pombe. 38
4020341 1985
712
Effects of antilipolytic agents on rat liver peroxisomes and peroxisomal oxidative activities. 38
3978124 1985
713
Characterization of Peroxisomes from the Alga Bumilleriopsis filiformis. 38
16664045 1985
714
[Why Dalmatians excrete uric acid. Causes and consequences of a classical metabolic disorder]. 38
4071531 1985
715
Conservation of vitamin C by uric acid in blood. 38
3836238 1985
716
Studies on antigenicity of the polyethylene glycol (PEG)-modified uricase. 38
2412977 1985
717
Uricase from fish liver: isolation and some properties. 38
4092430 1985
718
Hyperuricaemia in sickle cell disease. 38
6528354 1984
719
Defect of uric acid uptake in Dalmatian dog liver. 38
6510499 1984
720
Uptake of uric acid, xanthine and hypoxanthine by brush-border membrane vesicles from mouse small intestine. 38
6509051 1984
721
Differential pulse voltammetry: simultaneous in vivo measurement of ascorbic acid, catechols and 5-hydroxyindoles in the rat striatum. 38
6083820 1984
722
Evaluation of the enzymatic assay of serum uric acid with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen. 38
6517491 1984
723
The determination of molecular weight of proteins by gel permeation chromatography in organic solvents. 38
6480578 1984
724
Interference in colorimetric reactions for measuring hydrogen peroxide. 38
6210015 1984
725
Problems associated with the measurement of uric acid using two enzyme-mediated reaction systems. 38
6508211 1984
726
Highly sensitive flow injection analysis of glucose and uric acid in serum using an immobilized enzyme column and chemiluminescence. 38
6520074 1984
727
Purine synthesis and catabolism in soybean seedlings : the biogenesis of ureides. 38
16663743 1984
728
[A problem on the uric acid value of rats for clinical evaluation]. 38
6499936 1984
729
Technicon SMAC methods for uric acid: uricase and phosphotungstate compared. 38
6733923 1984
730
Induction and origin of hepatocytes in rat pancreas. 38
6202703 1984
731
Hypouricaemic effect after oral administration in chickens of polyethylene glycol-modified uricase entrapped in liposomes. 38
6145782 1984
732
Voltammetric carbon paste electrodes monitor uric acid and not 5-HIAA at the 5-hydroxyindole potential in the rat brain. 38
6203061 1984
733
Genetic studies of purine breakdown in the fission yeast Schizosaccharomyces pombe. 38
24177583 1984
734
Role of hyperuricaemia in critically ill patients especially newborns. 38
6383436 1984
735
Induction of tolerance in mice by uricase and monomethoxypolyethylene glycol-modified uricase. 38
6746105 1984
736
Differential pulse voltammetry in vivo--evidence that uric acid contributes to the indole oxidation peak. 38
6200805 1983
737
Measuring urate in the Technicon SMAC by using unbound uricase and omitting dialysis. 38
6627647 1983
738
Uricase from soybean root nodules: purification, properties, and comparison with the enzyme from cowpea. 38
6685457 1983
739
Separation and quantitation of oxypurines by isocratic high-pressure liquid chromatography: application to xanthinuria and the Lesch-Nyhan syndrome. 38
6651793 1983
740
Reversible alteration of hepatic messenger RNA species for peroxisomal and non-peroxisomal proteins induced by the hypolipidaemic drug Wy-14,643. 38
6626161 1983
741
Ontogeny of hepatic peroxisomal uricase activity in the mongrel puppy. 38
6622104 1983
742
Automated analysis of flour extracts for uric acid and its correlation with degree of insect defilement. 38
6863185 1983
743
Enzymes of ureide synthesis in pea and soybean. 38
16662981 1983
744
Isolation and characterization of infected and uninfected cells from soybean nodules : role of uninfected cells in ureide synthesis. 38
16662921 1983
745
Enzymes of purine metabolism in cancer. 38
6861338 1983
746
Status of glutathione in the rat liver. Enhanced formation of oxygen radicals at low oxygen tension. 38
6670997 1983
747
Nodulin-35: a subunit of specific uricase (uricase II) induced and localized in the uninfected cells of soybean nodules. 38
16453488 1983
748
[Uric acid determination in dilute serum with an enzyme electrochemical and enzyme-free sensor]. 38
6670996 1983
749
Kinetic method having a linear range for substrate concentrations that exceed Michaelis-Menten constants. 38
7139915 1982
750
Phthalate esters as peroxisome proliferator carcinogens. 38
6754363 1982
751
Four methods for determining uric acid compared with a candidate reference method. 38
7127737 1982
752
Cluster bean-a ureide- or amide-producing legume? 38
16662600 1982
753
[Cold adaptation and changes in peroxisome enzyme in various organs of the rat]. 38
6128006 1982
754
Enzymes of amide and ureide biogenesis in developing soybean nodules. 38
16662397 1982
755
Evaluation of the Technicon bound uricase method for the determination of uric acid in urine. 38
7108450 1982
756
Urate does not influence the formation of calcium oxalate crystals in whole human urine at pH 5.3. 38
7067361 1982
757
Uric acid determinations: reversed-phase liquid chromatography with ultraviolet detection compared with kinetic and equilibrium adaptations of the uricase method. 38
7067092 1982
758
Screening procedure for uric acid as indicator of infestation in spices. 38
7085543 1982
759
A candidate reference method for uric acid in serum. I. Optimization and evaluation. 38
7055949 1982
760
Urate uptake in membrane vesicles of rat renal cortex: effect of copper. 38
7065132 1982
761
A candidate reference method for uric acid in serum. II. Interlaboratory testing. 38
7055950 1982
762
Detection of uric acid in aqueous humor by high pressure liquid chromatography. 38
7186433 1982
763
Two-point kinetic determination of uric acid in serum with uricase, catalase and aldehyde dehydrogenase on the KONE CD analyser. 38
18927832 1982
764
Physicochemical properties and states of sulfhydryl groups of uricase from Candida utilis. 38
7200091 1982
765
Immobilized uricase for automated assay of uric acid in serum. 38
18927827 1982
766
Peroxisomal enzyme activities in regenerating liver of rats. 38
6131509 1982
767
Ultrastructural localization of urate oxidase in nodules of Sesbania exaltata, Glycine max, and Medicago sativa. 38
7201988 1982
768
[Effect of temperature increase on some aspects of nitrogen catabolism in rainbow trout (Salmo gairdneri Rich.)]. 38
7156505 1982
769
Ontogeny of renal uric acid excretion in the mongrel puppy. 38
7322672 1981
770
Enzymes of Purine Biosynthesis and Catabolism in Glycine max: I. COMPARISON OF ACTIVITIES WITH N(2) FIXATION AND COMPOSITION OF XYLEM EXUDATE DURING NODULE DEVELOPMENT. 38
16662061 1981
771
Modification of amino groups in Candida utilis uricase with naphthoquinone disulfonic acid in relation to the enzymic activity. 38
9222322 1981
772
The application of a sensitive uricase-peroxidase couple reaction to a centrifugal fast analyser for the determination of uric acid. 38
7296893 1981
773
Reduction of plasma urate levels in the cockerel with polyethylene glycol-uricase. 38
7288624 1981
774
Uricase immobilized onto nylon tube for use in automated analysis of serum urate. 38
7304984 1981
775
Localization of enzymes of ureide biosynthesis in peroxisomes and microsomes of nodules. 38
16661891 1981
776
Gut bacteria recycle uric acid nitrogen in termites: A strategy for nutrient conservation. 38
16593064 1981
777
Ureide Synthesis in a Cell-Free System from Cowpea (Vigna unguiculata [L.] Walp.) Nodules : STUDIES WITH O(2), pH, AND PURINE METABOLITES. 38
16661827 1981
778
The analysis of serum urate utilizing immobilized uricase. 38
24233654 1981
779
The acute effects of furosemide, ethacrynic acid and chlorothiazide on the renal tubular handling of uric acid in the chicken. 38
7205623 1981
780
[Study of crystals in synovial exudations with simultaneous determination of adequate enzymes]. 38
7223082 1981
781
Some kinetic studies on immobilized uricase. 38
7297747 1981
782
Improved modification of yeast uricase with polyethylene glycol, accompanied with nonimmunoreactivity towards anti-uricase serum and high enzymic activity. 38
7194181 1981
783
Uricase immobilized on walls of glass tubes used as reactors in continuous-flow analyses. 38
7449106 1981
784
Continuous-flow analysis for uric acid in biological fluids, with immobilized uricase in a closed-loop system. 38
7457889 1980
785
A new method for the determination of serum uric acid by measuring allantoid produced by the action of uricase. 38
7214610 1980
786
Uric Acid-Degrading Bacteria in Guts of Termites [Reticulitermes flavipes (Kollar)]. 38
16345587 1980
787
Thermodynamics and stoicheiometry of the binding of substrate analogues to uricase. 38
6821367 1980
788
Non-classical inhibition of uricase by cyanide. 38
6821368 1980
789
Purification and characterization of yeast protease B. 38
6993457 1980
790
Purification and characterization of uricase, a nitrogen-regulated enzyme, from Neurospora crassa. 38
6446884 1980
791
Determination of uric acid with uricase and peroxidase. 38
7357749 1980
792
Use of 3,5-dichloro-2-hydroxybenzenesulfonic acid/4-aminophenazone chromogenic system in direct enzymic assay of uric acid in serum and urine. 38
7353268 1980
793
[Nitrogen excretion of Helix aspersa Müller (Mollusca Gastropoda Pulmonata)]. 38
7224493 1980
794
Fibrin membrane endowed with biological function. V. Multienzyme complex of uricase, catalase, allantoinase and allantoicase. 38
6985799 1980
795
A new spectrophotometric assay for enzymes of purine metabolism. IV. Determination of adenosine deaminase. 38
7363876 1980
796
Nitrogen regulation of uricase synthesis in Neurospora crassa. 38
160493 1979
797
The use of immobilized enzyme reactors in continuous-flow analyzers for the determination of glucose, urea, and uric acid. 38
476924 1979
798
A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment. 38
518562 1979
799
Hyperxanthinemia interferes with serum uric acid determinations by the uricase method. 38
455692 1979
800
Serum uric acid. 38
474510 1979
801
A micromethod for plasma uric acid determinations in companion birds. 38
526210 1979
802
Main properties of ox kidney uricase. 38
42632 1979
803
Ox kidney uricase: a new method of purification. 38
521256 1979
804
Evaluation of three clinical chemical routine methods for the determination of serum uric acid, by mass fragmentography. 38
527221 1979
805
Fluorometric determination of xanthine and hypoxanthine in tissue. 38
583329 1979
806
Use of immobilized enzymes in automated clinical analysis: determination of uric acid and glucose using immobilized enzymes in column form. 38
527227 1979
807
Degradation of uric acid to urea and glyoxylate in peroxisomes. 38
447647 1979
808
Positive interference of catecholamine metabolites with quantitation of urinary uric acid by the direct acid ferric-reduction method. 38
436251 1979
809
Improved automated kinetic determination of uric acid in serum by use of uricase/catalase/aldehyde dehydrogenase. 38
466770 1979
810
Mechanism of uricase action. 38
36153 1979
811
Adrenal epinephrine in hyperuricemia induced by hypothalamic stimulation of the rat. 38
426051 1979
812
Thymol is a suitable preservative for uric acid standards in the uricase technique. 38
759034 1979
813
Purification of uricase from mammalian tissue. 38
35787 1979
814
Modification of yeast uricase with polyethylene glycol: disappearance of binding ability towards anti-uricase serum. 38
573687 1979
815
Immobilized enzymes in continuous-flow analysis. 38
761373 1979
816
A new spectrophotometric assay for enzymes of purine metabolism. I. Determination of xanthine oxidase activity. 38
488056 1979
817
A new spectrophotometric assay for enzymes of purine metabolism. II. Determination of guanase activity. 38
488057 1979
818
In vitro and in vivo activity of soluble cross-linked uricase-albumin polymers: a model for enzyme therapy. 38
763074 1979
819
Uricase of Bacillus fastidiosus. Properties and regulation of synthesis. 38
728443 1978
820
Allantoxanamide: a potent new uricase inhibitor in vivo. 38
723476 1978
821
Immobilized-enzyme membrane sandwich reactor used in automated micro-scale assay of plasma uric acid. 38
709842 1978
822
Chromosomal location of genes participating in the degradation of purines in Pseudomonas aeruginosa. 38
104142 1978
823
New enzymatic method for serum uric acid at 500 nm. 38
709818 1978
824
Isolation and biochemical properties of two types of microbody from Neurospora crassa cells. 38
152214 1978
825
Allantoin and Allantoic Acid in the Nitrogen Economy of the Cowpea (Vigna unguiculata [L.] Walp.). 38
16660546 1978
826
Immobilized-enzyme nylon-tube reactor for routine determination of uric acid in serum. 38
699291 1978
827
Biogenesis of peroxisomes: intracellular site of synthesis of catalase and uricase. 38
368807 1978
828
[Enzymatic determination of uric acid in serum with the trinder reaction (author's transl)]. 38
752830 1978
829
Immunogenicity and antigenicity of soluble cross-linked enzyme/albumin polymers: Advantages for enzyme therapy. 38
78296 1978
830
A two-stage enzymatic method for determination of uric acid and hypoxanthine/xanthine. 38
657544 1978
831
[Adaptation of the SMAC for the determination of uric acid with an uricase/perioxidase procedure (author's transl)]. 38
641455 1978
832
New ultraviolet (340 nm) method for assay of uric acid in serum or plasma. 38
639259 1978
833
Uric acid metabolism in homozygous and heterozygous muscular dystrophic mice. 38
645859 1978
834
Platelet aggregation in rats in relation to hyperuricaemia induced by dietary single-cell protein and to protein deficiency. 38
580986 1978
835
Portacaval shunt in the rat: an animal model for evaluation of uricase activity. 38
684028 1978
836
Determination of uric acid on continuous-flow (AutoAnalyzer II and SMA) systems with a uricase/phenol/4-aminophenazone color test. 38
627057 1978
837
Use of the uricase-inhibited rat as an animal model in toxicology. 38
367691 1978
838
A purine N1-C6 hydrolase activity in the chicken egg yolk: a vestigial enzyme? 38
564265 1978
839
Values for uric acid in patients' sera as measured with SMAC (phosphotungstate) and AutoAnalyzer (uricase) 38
618654 1978
840
Production of uricase by Candida tropicalis using n-alkane as a substrate. 38
200173 1977
841
Enzyme-coupled measurement of uric acid in serum with a centrifugal analyzer. 38
890896 1977
842
Purine degradation in Pseudomonas aeruginosa and Pseudomonas testosteroni. 38
407941 1977
843
The defect of uric acid metabolism in Eck-fistula rats. 38
17644 1977
844
[Globulinopathy and hyperuricemia]. 38
899299 1977
845
Determination of uric acid by the uricase-catalase system using the ABA 100. 38
859379 1977
846
Inhibition of uricase by substituted pyrimidines. 38
851446 1977
847
Properties of enzymes immobilized by the diazotized m-diaminobenzene method. 38
14749 1977
848
A precise semi-automated uricase method for determining uric acid in serum or urine. 38
837524 1977
849
Calorimetric enzymic measurement of uric acid in serum. 38
832382 1977
850
[Evidence of an excretion of uric acid by a caecal pouch in the rabbit (author's transl)]. 38
879677 1977
851
Purification of uricase by biospecific adsorption-desorption. 38