MCID: URM002
MIFTS: 49

Uremia

Categories: Nephrological diseases

Aliases & Classifications for Uremia

MalaCards integrated aliases for Uremia:

Name: Uremia 12 74 54 43 15 17 71
Uremia of Renal Origin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4676
MeSH 43 D014511
SNOMED-CT 67 44730006
ICD10 32 N19
UMLS 71 C0041948

Summaries for Uremia

MalaCards based summary : Uremia, also known as uremia of renal origin, is related to end stage renal disease and hyperparathyroidism. An important gene associated with Uremia is EPO (Erythropoietin), and among its related pathways/superpathways are Adipogenesis and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Histamine and Fexofenadine have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and liver, and related phenotypes are cardiovascular system and cellular

Wikipedia : 74 Uremia is the condition of having high levels of urea in the blood. Urea is one of the primary... more...

Related Diseases for Uremia

Diseases related to Uremia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 551)
# Related Disease Score Top Affiliating Genes
1 end stage renal disease 33.0 PTH PON1 EPO CRP ALB
2 hyperparathyroidism 31.5 VDR TNFRSF11B PTH EPO CASR ALB
3 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 31.5 EPO CRP ALB
4 secondary hyperparathyroidism 31.2 VDR TNFRSF11B PTH EPO CASR B2M
5 chronic pyelonephritis 31.2 CRP B2M ALB
6 deficiency anemia 31.1 PTH PON1 EPO CRP ALB
7 homocysteinemia 31.1 VWF PON1 CRP ALB
8 osteitis fibrosa 31.1 PTH CASR B2M
9 uremic neuropathy 31.1 PTH EPO B2M
10 osteomalacia 31.1 VDR PTH CASR
11 pericarditis 31.1 RETN LEP CRP ALB
12 glomerulonephritis 31.1 SPP1 NOS2 B2M ALB
13 renal osteodystrophy 31.1 VDR TNFRSF11B PTH EPO CASR
14 peripheral nervous system disease 30.9 LEP EPO CRP B2M ALB
15 hyperphosphatemia 30.9 VDR TNFRSF11B SPP1 PTH CRP CASR
16 pulmonary tuberculosis 30.9 VDR CRP ALB
17 bone disease 30.9 VDR TNFRSF11B SPP1 PTH EPO CASR
18 hypercholesterolemia, familial, 1 30.8 LPL GHR CRP
19 interstitial nephritis 30.8 CRP B2M ALB
20 renal hypertension 30.8 EPO CRP ALB
21 urinary tract obstruction 30.8 CRP B2M ALB
22 active peptic ulcer disease 30.8 VWF CRP ALB
23 polyneuropathy 30.8 EPO CRP B2M ALB
24 rickets 30.8 VDR SPP1 PTH CASR ALB
25 arteriosclerosis 30.7 SPP1 PON1 LPL CRP
26 peritonitis 30.7 NOS2 CRP B2M ALB
27 arteries, anomalies of 30.7 VWF LEP CRP ALB
28 pulmonary edema 30.7 NOS2 EPO CRP
29 acute pancreatitis 30.6 RETN LPL CRP ALB
30 primary hyperparathyroidism 30.6 VDR TNFRSF11B PTH CASR ALB
31 parathyroid adenoma 30.6 VDR PTH CASR
32 hypophosphatemia 30.6 VDR SPP1 PTH B2M ALB
33 aortic atherosclerosis 30.6 SPP1 PON1 LPL
34 hyperuricemia 30.6 PTH LEP CRP ALB
35 lipoprotein quantitative trait locus 30.5 VWF PON1 CRP ALB
36 glucose intolerance 30.5 RETN LPL LEP GH1 CRP ALB
37 iron deficiency anemia 30.5 PON1 EPO CRP
38 insulin-like growth factor i 30.5 LEP GHR GH1
39 miliary tuberculosis 30.4 EPO CRP ALB
40 nephrocalcinosis 30.4 SPP1 PTH CASR ALB
41 hydronephrosis 30.4 VWF CRP B2M ALB
42 lipid metabolism disorder 30.4 RETN PON1 LPL LEP CRP APOC3
43 thrombophlebitis 30.4 VWF CRP ALB
44 hypoparathyroidism 30.3 VDR PTH CASR
45 pulmonary embolism 30.3 VWF CRP ALB
46 acute cystitis 30.3 OXA1L CRP ALB
47 fanconi syndrome 30.3 PTH B2M ALB
48 hyperinsulinism 30.3 RETN LPL LEP GHR GH1
49 sickle cell anemia 30.3 VWF EPO CRP ALB
50 analbuminemia 30.2 OXA1L EPO CRP ALB

Graphical network of the top 20 diseases related to Uremia:



Diseases related to Uremia

Symptoms & Phenotypes for Uremia

MGI Mouse Phenotypes related to Uremia:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 ALB B2M CRP EPO GHR LEP
2 cellular MP:0005384 10.32 ALB B2M CASR EPO GHR LEP
3 homeostasis/metabolism MP:0005376 10.31 AHSG ALB B2M CASR CRP EPO
4 immune system MP:0005387 10.25 ALB B2M CASR CRP EPO GHR
5 hematopoietic system MP:0005397 10.2 B2M CASR EPO GHR LEP NOS2
6 integument MP:0010771 10.02 B2M CASR EPO GHR LEP LPL
7 mortality/aging MP:0010768 10 ALB B2M CASR EPO GHR LEP
8 liver/biliary system MP:0005370 9.91 ALB B2M EPO GHR LEP LPL
9 limbs/digits/tail MP:0005371 9.87 AHSG EPO GHR LEP PTH TNFRSF11B
10 muscle MP:0005369 9.65 AHSG ALB CASR EPO GHR LEP
11 skeleton MP:0005390 9.32 AHSG CASR EPO GHR LEP NOS2

Drugs & Therapeutics for Uremia

Drugs for Uremia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 192)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6 774
2
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
3
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
4
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
5
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
6
Hydralazine Approved Phase 4 86-54-4 3637
7
Enalaprilat Approved Phase 4 76420-72-9 6917719
8
Cefazolin Approved Phase 4 25953-19-9 656510 33255
9
leucovorin Approved Phase 4 58-05-9 6006 143
10
Metformin Approved Phase 4 657-24-9 14219 4091
11
Glipizide Approved, Investigational Phase 4 29094-61-9 3478
12
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7, 161973-10-0 9568614 4594
13
tannic acid Approved Phase 4 1401-55-4
14
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
15
carbamide peroxide Approved Phase 4 124-43-6
16
Liraglutide Approved Phase 4 204656-20-2 44147092
17
Pamidronate Approved Phase 4 40391-99-9 4674
18
Pantoprazole Approved Phase 4 102625-70-7 4679
19
Amlodipine Approved Phase 4 88150-42-9 2162
20
Terlipressin Approved, Investigational Phase 4 14636-12-5 72081
21
Somatostatin Approved, Investigational Phase 4 38916-34-6, 51110-01-1 53481605
22
Zinc Approved, Investigational Phase 4 7440-66-6 32051
23
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
24
Losartan Approved Phase 4 114798-26-4 3961
25
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
26
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
27
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
28 Psychotropic Drugs Phase 4
29 HIV Protease Inhibitors Phase 4
30
protease inhibitors Phase 4
31 Anti-Anxiety Agents Phase 4
32 Anti-Allergic Agents Phase 4
33 Histamine H1 Antagonists Phase 4
34 Histamine H1 Antagonists, Non-Sedating Phase 4
35 Histamine Antagonists Phase 4
36
Histamine Phosphate Phase 4 51-74-1 65513
37 Analgesics Phase 4
38 Anticonvulsants Phase 4
39 Adrenergic beta-Antagonists Phase 4
40 Pharmaceutical Solutions Phase 4
41 Dialysis Solutions Phase 4
42 Vitamin B Complex Phase 4
43 Folate Phase 4
44 Vitamin B9 Phase 4
45 Micronutrients Phase 4
46 Vitamins Phase 4
47 Trace Elements Phase 4
48 Nutrients Phase 4
49 Incretins Phase 4
50 Hormones Phase 4

Interventional clinical trials:

(show top 50) (show all 135)
# Name Status NCT ID Phase Drugs
1 The Clinical Use of Probiotics in the Uremia Patients Under Chronic Peritoneal Dialysis Unknown status NCT01076426 Phase 4 Pro-biotics
2 A Multicenter, Double-blind, Randomized, Placebo and Active-controlled Study of Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
3 The Effect of Enalapril and Losartan on Peritoneal Membrane in Continuous Ambulatory Peritoneal Dialysis Patients Unknown status NCT01041963 Phase 4 Enalapril;Enalapril plus Losartan;Placebo
4 The Effect of Aliskiren and Losartan on Peritoneal Membrane in Continuous Ambulatory Peritoneal Dialysis Patients Unknown status NCT01305850 Phase 4 placebo;Aliskiren;Aliskiren plus Losartan;Enalapril plus Losartan
5 The Impact of Early Feeding Following Ligation of the Acute Bleeding Varices Unknown status NCT01287702 Phase 4
6 Gut-kidney Axis: Renal Effects of Meditarranean Diet and Low-protein Diet With Ketoacids to Restore Physiological Intestinal Mibrobiota in Chronic Kidney Disease Unknown status NCT02302287 Phase 4
7 Prophylactic Administration of Antibiotics Before Radiofrequency Ablation for Hepatocellular Carcinoma: A Randomized Trial Unknown status NCT02534961 Phase 4 Cefazolin
8 Randomized Clinical Trial of Folate Therapy/Placebo for Reduction of Homocysteine Serum Levels in Uremic Patients and Influence on Cardiovascular Mortality Completed NCT00317005 Phase 4 folate treatment
9 Phase 4 Study on the Prognosis and Effect of Anti-diabetic Drugs on Type-2 Diabetes Mellitus With Coronary Artery Disease Completed NCT00513630 Phase 4 Glipizide;Metformin
10 PHASE 4 STUDY OT THE EFFECT OF GLUCOSE ADDED TO THE DIALYSIS FLUID ON BLOOD PRESSURE, BLOOD GLUCOSE AND QUALITY OF LIFE IN HEMODIALYSIS PATIENTS. Completed NCT00278057 Phase 4 dialysisis with and without glucose in the dialysis
11 Effect of Heat Disinfection of HD Water Treatment System on Cardiovascular Events and Outcome in Hemodialysis Patients Completed NCT01138280 Phase 4
12 The Rates of Complete Symptom Relief,Prevetion of Symptom Relapse and Maintenance of Esophagitis Healing for 4-week Versus 8-week Esomeprazole Therapy Among Los Angeles Grades A and B Erosive Esophagitis Completed NCT01874535 Phase 4 Esomeprazole 40 mg
13 Uremic Pruritus, Cytokines and Polymethylmethacrylate Artificial Kidney Completed NCT00442819 Phase 4
14 The Hannover-Dialysis-Outcome (HAN-D-OUT)-Study: Comparison of Standard Versus Intensified Extended Dialysis in Treatment of Patients With Acute Kidney Injury in the Intensive-Care Unit Completed NCT00529139 Phase 4
15 An Open Label, Multi-Center Study of the Effect of Paricalcitol on Markers of Inflammation in Patients With Stage 5 Chronic Kidney Disease on Hemodialysis. Completed NCT00294866 Phase 4 Paricalcitol
16 Safety and Effect of Liraglutide in Patients With Type 2 Diabetes and Severe Renal Insufficiency Completed NCT01394341 Phase 4 Liraglutide
17 Effect of Oral Vitamin C on The Inflammatory Biomarkers in Hemodialysis Completed NCT01356433 Phase 4 oral vitamin C;oral vitamin C
18 Effects of Neutral pH and Low Glucose Degradation Product-containing Peritoneal Dialysis Fluid on Systemic Markers of Inflammation and Endothelial Dysfunction: a Randomized, Controlled 1-year Follow-up Study Completed NCT01315314 Phase 4 Balance, Fresenius Medical Care, Germany
19 Osteopenia and Renal Osteodystrophy: Evaluation and Management Completed NCT00108394 Phase 4 pamidronate
20 1-deamino 8-d-arginine Vasopressin in Percutaneous Ultrasound-guided Renal Biopsy: a Randomized Controlled Trial Completed NCT00748072 Phase 4 DDAVP;saline solution
21 Efficacy and Safety of a Very Low Protein Diet in Postponing Dialysis in Elderly: a Prospective Randomized Multicenter Controlled Study Completed NCT00388648 Phase 4 mixture of amino and keto acids
22 Ivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan Completed NCT02241044 Phase 4
23 Influence of Amlodipine on the Mortality of Patients With End-Stage Renal Failure (ADAM [Amlodipine and Dialysis Patients, Action on Mortality]) Completed NCT00124969 Phase 4 Amlodipine;Placebo
24 Short-course Somatostatin Versus Terlipressin Infusion in Combination With Endoscopic Variceal Ligation for the Prevention of Early Esophageal Variceal Rebleeding Completed NCT02757703 Phase 4 Somatostatin;Terlipressin;Pantoprazole
25 Effect of Replacement Volume and AST-120 (Kremezin) on Protein-bound Toxins, Oxidative Stress and MicroInflammation in Patients Receiving Online Hemodiafiltration Completed NCT01458652 Phase 4 Kremezin
26 A Comparison of Insulin Sensitivity and Management in Hyperglycemic Patients in the Perioperative Period: ESRD vs. Non-ESRD Recruiting NCT03526536 Phase 4 IV Novolin R human insulin
27 Effect of Add-on Spironolactone to Losartan Versus Losartan Alone on Peritoneal Membrane Among Continuous Ambulatory Peritoneal Dialysis Patients: An Open-Label Randomized-Controlled Trial Not yet recruiting NCT03953950 Phase 4 Spironolactone;Losartan
28 Circuit Survival and Efficacy for Middle Molecular-weight Solute Elimination Between Nafamostat Infusion and Heparinized Saline Priming Unknown status NCT01486485 Phase 3 heparinized saline priming group;nafamostat infusion after heparinized saline priming
29 Effects of Short-chain Fatty Acids, Here Sodium Propionate, a Metabolism Product of the Human Gut-microbiome, on Inflammatory and Metabolic Parameters in Patients on Maintenance Hemodialysis - a Pilot Study Unknown status NCT02976688 Phase 2, Phase 3
30 Effects of Convective Therapies in Dialysis Patients Completed NCT01583309 Phase 3
31 The Effect and Safety of Combination Hemodialysis and Hemoperfusion on Severe Renal Osteopathy and Itching in Uremia Patients Completed NCT02747979 Phase 2, Phase 3
32 Plasma Exchange and Glucocorticoid Dosing in the Treatment of Anti-neutrophil Cytoplasm Antibody Associated Vasculitis: an International Randomized Controlled Trial Completed NCT00987389 Phase 3 Glucocorticoids [Standard Dose];Glucocorticoids [Reduced Dose]
33 Application of the Biological Fibrin Based Adhesive for the Prevention of Surgical Complications in the Kidney Transplant Completed NCT01631448 Phase 3
34 Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis (Sleep-HD) Recruiting NCT03534284 Phase 3 Trazodone;Placebo
35 Micro-elimination of Hepatitis C Virus Infection With Pan-genotypic DAA Regimen in Hepatitis C Highly Endemic and Contagious Community (ERASE-C) Recruiting NCT03891550 Phase 3 Epclusa
36 Forced Diuresis Vs Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients (Fodorefh) Terminated NCT00298454 Phase 3 Furosemide
37 Effect of Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cell in Kidney Transplantation From Chinese Donation After Citizen Death (DCD): A Randomized Controlled Trial Unknown status NCT02492490 Phase 1, Phase 2 Basiliximab
38 Randomized Cross-over Trial of Oral L-Glutamine vs Maltodextrin on Mitochondrial Function in Chronic Kidney Disease Unknown status NCT02838979 Phase 2
39 The Efficacy and Safety of Bone Marrow-derived Mesenchymal Stem Cells in Kidney Transplantation From Chinese Donation After Citizen Death (DCD): A Multi-center Randomized Controlled Trial Unknown status NCT02561767 Phase 1, Phase 2 Induction therapy (ATG or Basiliximab);Maintenance therapy (Low-dose CNI + MPA + steroids)
40 Phase 1 RCT of Progressive Resistance Training on Small Solute Clearance, Functional Capacity and Quality of Life in Intradialysis Patients Unknown status NCT01065389 Phase 2
41 A Prospective, Open-Label, Pilot Study of Clonal Deletion on Living-Relative Donor Kidney Transplantation Unknown status NCT01408797 Phase 1, Phase 2 MMF, Bortezomib
42 Effect of Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cell in Living-Related Kidney Transplants: A Randomized Controlled Trial Unknown status NCT02492308 Phase 1, Phase 2 Basiliximab induction
43 Treatment of Uremic Pruritus by Olive-omega 3 Ointment Unknown status NCT01447693 Phase 1, Phase 2
44 A Randomised Trial of Prednisone and Tamoxifen in Patients With Idiopathic Retroperitoneal Fibrosis Unknown status NCT00440349 Phase 2 Tamoxifen;Prednisone
45 Clinical and Biochemical Effects of Multipass Hemodialysis Completed NCT01267760 Phase 2
46 Omega-3 Fatty Acid Administration in Dialysis Patients Completed NCT00655525 Phase 2
47 A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, CROSS-OVER STUDY TO EVALUATE THE RENAL AND BIOHUMORAL EFFECTS OF L-CYSTEINE COMPARED TO PLACEBO IN STABLE PERITONEAL DIALYSIS PATIENTS WITH RESIDUAL DIURESIS Completed NCT02050139 Phase 2
48 Vitamin D, Insulin Resistance and Inflammation in ESRD Completed NCT00656032 Phase 2
49 Evaluate the Effects of Turmeric on Oxidative Stress Markers in HD Patients Completed NCT01906840 Phase 1, Phase 2 Turmeric;placebo
50 An Exploratory/Proof of Concept Investigation of the Safety and Pharmacodynamics of LY2127399 in HLA-Presensitized Patients With End-Stage Renal Disease Awaiting Transplantation Completed NCT01200290 Phase 2 LY2127399

Search NIH Clinical Center for Uremia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Activated Charcoal
Charcoal
CHARCOAL,ACTIVATED PWDR

Cochrane evidence based reviews: uremia

Genetic Tests for Uremia

Anatomical Context for Uremia

MalaCards organs/tissues related to Uremia:

40
Kidney, Bone, Liver, Endothelial, Testes, Brain, Heart

Publications for Uremia

Articles related to Uremia:

(show top 50) (show all 8644)
# Title Authors PMID Year
1
The emerging pleiotrophic role of adipokines in the uremic phenotype. 61 54
19823084 2010
2
Serum-soluble Fas and serum levels of erythropoietin in chronic kidney disease. 54 61
20040346 2010
3
Antioxidant properties of some different molecular weight chitosans. 61 54
19559405 2009
4
Lipoprotein lipase disturbances induced by uremia and hemodialysis. 54 61
19708998 2009
5
Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease. 54 61
19212416 2009
6
Serum albumin fragmentation in end-stage renal disease patients--a pilot study. 61 54
19778290 2009
7
Antioxidant effects of a dietary supplement: reduction of indices of oxidative stress in normal subjects by water-soluble chitosan. 54 61
18996432 2009
8
Antioxidant protection of human serum albumin by chitosan. 54 61
18514811 2008
9
Effect of simvastatin in apolipoprotein E deficient mice with surgically induced chronic renal failure. 61 54
18295249 2008
10
[Effects of metal-catalyzed oxidation on the formation of advanced oxidation protein products]. 61 54
18642767 2008
11
[Relationship between cardiovascular complication and inflammation, oxidative stress of patient with maintenance hemodialysis]. 54 61
18390217 2008
12
Response of the growth plate of uremic rats to human growth hormone and corticosteroids. 61 54
17665047 2007
13
Oxidative stress and delta-ALA-D activity in chronic renal failure patients. 54 61
17383846 2007
14
Osteoprotegerin and RANKL serum levels and their relationship with serum ghrelin in children with chronic renal failure and on dialysis. 61 54
17259742 2007
15
Alteration of serum semicarbazide-sensitive amine oxidase activity in chronic renal failure. 54 61
17431736 2007
16
Mechanisms of disease: Cytokine and adipokine signaling in uremic cachexia. 54 61
16941045 2006
17
Circulating osteoprotegerin affects bone metabolism in dialysis patients with mild secondary hyperparathyroidism. 54 61
16817791 2006
18
Drug-associated disease: hematologic dysfunction. 54 61
16678004 2006
19
Circulating growth hormone binding protein levels and mononuclear cell growth hormone receptor expression in uremia. 61 54
16567271 2006
20
Direct in vitro evidence of the suppressive effect of cinacalcet HCl on parathyroid hormone secretion in human parathyroid cells with pathologically reduced calcium-sensing receptor levels. 61 54
16816924 2006
21
Hyperleptinemia is not responsible for decreased paraoxonase activity in hemodialysis patients. 61 54
16534235 2006
22
[Inflammatoin, oxidative stress and carbonyl stress in uremic patients]. 54 61
16468659 2006
23
Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1. 54 61
16291838 2006
24
Oxidation and carboxy methyl lysine-modification of albumin: possible involvement in the progression of oxidative stress in hemodialysis patients. 54 61
16671336 2005
25
Maxacalcitol therapy decreases circulating osteoprotegerin levels in dialysis patients with secondary hyperparathyroidism. 54 61
16047647 2005
26
Role of leptin and melanocortin signaling in uremia-associated cachexia. 54 61
15931394 2005
27
Quotidian nocturnal hemodialysis improves cytokine profile and enhances erythropoietin responsiveness. 61 54
15968953 2005
28
Growth hormone resistance in uremia, a role for impaired JAK/STAT signaling. 54 61
15692835 2005
29
The John F. Maher Recipient Lecture 2004: Rage in the peritoneum. 54 61
15770917 2005
30
Lymphocyte 5'-nucleotidase and aminopeptidase N activity in patients on maintenance hemodialysis treated with human recombinant erythropoietin and 1-alpha-D3. 54 61
15957544 2005
31
Serum paraoxonase activity in uremic predialysis and hemodialysis patients. 54 61
15593056 2004
32
Regulation of PTH1 receptor expression by uremic ultrafiltrate in UMR 106-01 osteoblast-like cells. 61 54
14871409 2004
33
Plasma cell membrane glycoprotein 1 (PC-1): a marker of insulin resistance in obesity, uremia and diabetes mellitus. 61 54
15209435 2004
34
Leptin, ghrelin, and proinflammatory cytokines: compounds with nutritional impact in chronic kidney disease? 54 61
14681862 2003
35
Involution of the parathyroid glands after renal transplantation. 54 61
12815332 2003
36
Paraoxonase activity and paraoxonase 1 gene polymorphism in patients with uremia. 54 61
12790379 2003
37
Contribution of quinolinic acid in the development of anemia in renal insufficiency. 54 61
12620922 2003
38
[Atherosclerosis and uremia: signifance of non-traditional risk factors]. 61 54
12778774 2003
39
[Renal bone disease and osteoprotegerin]. 54 61
15775096 2003
40
New markers of accelerated atherosclerosis in end-stage renal disease. 54 61
12649530 2003
41
Impaired protein binding of Chinese medicine DanShen in uremic sera and sera with hyperbilirubinemia: rapid assessment of total and free DanShen concentrations using the fluorescence polarization immunoassay for digoxin. 61 54
12938147 2003
42
Chronic liver and renal diseases differently affect structure of human serum albumin. 54 61
12485604 2002
43
The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. 61 54
12371953 2002
44
[The skeletal resistance to PTH and osteoprotegerin]. 61 54
15775364 2002
45
Novel erythropoiesis stimulating protein exerts an effect on platelet function in uremia equivalent to that exerted by recombinant human erythropoietin. 54 61
12010672 2002
46
Relationship of paraoxonase and serum lipids in Taiwan. 61 54
12149827 2002
47
[Some parameters of platelet activation in patients with uremia before and after hemodialysis (HD)]. 61 54
12731371 2002
48
Metabolic consequences of hyperhomocysteinemia in uremia. 54 61
11576929 2001
49
Osteoprotegerin levels before and after renal transplantation. 54 61
11576949 2001
50
Carnitine metabolism in uremia. 54 61
11576925 2001

Variations for Uremia

Expression for Uremia

Search GEO for disease gene expression data for Uremia.

Pathways for Uremia

GO Terms for Uremia

Cellular components related to Uremia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 VWF TNFRSF11B SPP1 RETN PTH PON1
2 extracellular space GO:0005615 9.5 TNFRSF11B SPP1 RETN PTH PON1 LPL
3 platelet alpha granule lumen GO:0031093 9.43 VWF ALB AHSG
4 chylomicron GO:0042627 9.37 LPL APOC3
5 spherical high-density lipoprotein particle GO:0034366 9.32 PON1 APOC3
6 growth hormone receptor complex GO:0070195 9.16 GHR GH1

Biological processes related to Uremia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.8 SPP1 B2M ALB AHSG
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.73 LEP GH1 EPO
3 skeletal system development GO:0001501 9.73 VDR TNFRSF11B PTH AHSG
4 response to nutrient GO:0007584 9.71 TNFRSF11B LEP EPO
5 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.58 GHR GH1
6 intestinal absorption GO:0050892 9.57 VDR LEP
7 growth hormone receptor signaling pathway GO:0060396 9.55 GHR GH1
8 regulation of cytokine production involved in inflammatory response GO:1900015 9.52 NOS2 LEP
9 negative regulation of lipid storage GO:0010888 9.51 LEP CRP
10 acute-phase response GO:0006953 9.5 EPO CRP AHSG
11 chylomicron remodeling GO:0034371 9.48 LPL APOC3
12 response to fibroblast growth factor GO:0071774 9.46 PTH CASR
13 interleukin-8 secretion GO:0072606 9.4 NOS2 LEP
14 interleukin-6 secretion GO:0072604 9.37 NOS2 LEP
15 positive regulation of JAK-STAT cascade GO:0046427 9.33 LEP GHR GH1
16 prostaglandin secretion GO:0032310 9.26 NOS2 LEP
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.26 LEP GHR GH1 EPO
18 response to nutrient levels GO:0031667 8.92 PTH PON1 LEP GH1

Molecular functions related to Uremia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.5 PON1 OXA1L NOS2 LPL GHR CASR
2 peptide hormone receptor binding GO:0051428 9.16 PTH LEP
3 hormone activity GO:0005179 9.02 RETN PTH LEP GH1 EPO

Sources for Uremia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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