Aliases & Classifications for Uremic Pruritus

MalaCards integrated aliases for Uremic Pruritus:

Name: Uremic Pruritus 59 73

Characteristics:

Orphanet epidemiological data:

59
uremic pruritus
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

Orphanet 59 ORPHA94059
UMLS via Orphanet 74 C1262019
UMLS 73 C1262019

Summaries for Uremic Pruritus

MalaCards based summary : Uremic Pruritus is related to peritonitis and systemic onset juvenile idiopathic arthritis. An important gene associated with Uremic Pruritus is IL18 (Interleukin 18), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Gabapentin and Fexofenadine have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and lymph node, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 76 Uremic pruritus (also known as uraemic pruritus or renal pruritus) is caused by chronic kidney failure... more...

Related Diseases for Uremic Pruritus

Diseases related to Uremic Pruritus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 peritonitis 30.3 CRP IL1B IL6
2 systemic onset juvenile idiopathic arthritis 10.8 IL18 IL1B
3 schnitzler syndrome 10.8 IL18 IL1B
4 pericoronitis 10.6 CRP IL1B
5 suppurative otitis media 10.6 CRP IL1B
6 autoimmune myocarditis 10.6 IL1B IL2
7 familial cold autoinflammatory syndrome 10.6 IL18 IL1B
8 t-cell large granular lymphocyte leukemia 10.6 IL18 IL2
9 crohn's colitis 10.6 IL1B IL2
10 pharyngitis 10.6 CRP IL1B
11 muckle-wells syndrome 10.6 CRP IL1B
12 recurrent corneal erosion 10.5 IL1B IL6
13 bagassosis 10.5 IL1B IL6
14 periodontitis, chronic 10.5 IL1B IL6
15 pleural disease 10.5 CRP IL1B
16 funisitis 10.5 IL1B IL6
17 glossitis 10.5 IL1B IL6
18 euthyroid sick syndrome 10.5 IL1B IL6
19 laryngitis 10.5 IL1B IL6
20 lung sarcoma 10.5 IL18 IL2
21 ascaris lumbricoides infection 10.5 IL1B IL6
22 acute vascular insufficiency of intestine 10.5 IL1B IL6
23 cyclic vomiting syndrome 10.5 CNR1 IL6
24 poems syndrome 10.5 IL1B IL6
25 periapical periodontitis 10.5 IL1B IL6
26 osteosclerotic myeloma 10.5 IL1B IL6
27 vaginal disease 10.5 IL1B IL6
28 endometrial disease 10.5 IL1B IL6
29 cold agglutinin disease 10.5 CRP IL6
30 vaginitis 10.5 IL1B IL6
31 palindromic rheumatism 10.5 CRP IL1B
32 primary amebic meningoencephalitis 10.5 IL1B IL6
33 cryopyrin-associated periodic syndrome 10.5 CRP IL6
34 cardiogenic shock 10.5 CRP IL6
35 hydrarthrosis 10.4 IL1B IL6
36 acute cholangitis 10.4 CRP IL6
37 eales disease 10.4 IL1B IL6
38 neutrophilia, hereditary 10.4 CRP IL6
39 spinal disease 10.4 CRP IL6
40 castleman disease 10.4 CRP IL6
41 angina pectoris 10.4 CRP IL6
42 viral pneumonia 10.4 CRP IL6
43 joint disorders 10.4 IL1B IL6
44 cecal disease 10.4 CRP IL6
45 relapsing polychondritis 10.4 CRP IL6
46 pulpitis 10.4 IL1B IL6
47 subacute thyroiditis 10.4 CRP IL6
48 intussusception 10.4 CRP IL6
49 gingival disease 10.4 IL1B IL6
50 louse-borne relapsing fever 10.4 CRP IL6

Graphical network of the top 20 diseases related to Uremic Pruritus:



Diseases related to Uremic Pruritus

Symptoms & Phenotypes for Uremic Pruritus

MGI Mouse Phenotypes related to Uremic Pruritus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 CNR1 IL18 IL2 IL6 OPRK1
2 homeostasis/metabolism MP:0005376 9.23 IL6 OPRK1 SLC17A5 CNR1 CRP IL18

Drugs & Therapeutics for Uremic Pruritus

Drugs for Uremic Pruritus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4,Not Applicable 60142-96-3 3446
2
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
3
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
4
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
5
Benzyl alcohol Approved Phase 4 100-51-6 244
6
Ethanol Approved Phase 4 64-17-5 702
7
Petrolatum Approved, Investigational Phase 4 8009-03-8
8
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
9
Tocopherol Approved, Investigational, Nutraceutical Phase 4 1406-66-2 14986
10
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
11
Histamine Phosphate Phase 4 51-74-1 65513
12 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
13 calcium channel blockers Phase 4,Not Applicable
14 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
15 Neurotransmitter Agents Phase 4,Not Applicable
16 Histamine Antagonists Phase 4
17 Histamine H1 Antagonists Phase 4
18 Histamine H1 Antagonists, Non-Sedating Phase 4
19 Tranquilizing Agents Phase 4,Not Applicable
20 Anti-Allergic Agents Phase 4
21 Anti-Anxiety Agents Phase 4,Not Applicable
22 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
23 Anticonvulsants Phase 4,Not Applicable
24 Psychotropic Drugs Phase 4,Not Applicable
25 Calcium, Dietary Phase 4,Not Applicable
26 Tocopherols Phase 4
27 Anesthetics Phase 4
28 Anesthetics, Local Phase 4
29 Vasodilator Agents Phase 4
30 Polymethyl Methacrylate Phase 4
31 Pramoxine Phase 4
32 Protective Agents Phase 4
33 Carbopol 940 Phase 4
34 Citrate Nutraceutical Phase 4
35
Nalbuphine Approved Phase 2, Phase 3,Phase 3,Phase 1 20594-83-6 5360630 5311304
36
Diphenhydramine Approved, Investigational Phase 2, Phase 3 147-24-0, 58-73-1 3100
37
Promethazine Approved, Investigational Phase 2, Phase 3 60-87-7 4927
38 Emollients Phase 3,Not Applicable
39 Narcotic Antagonists Phase 2, Phase 3,Phase 3,Phase 1
40 Narcotics Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
41 Analgesics, Opioid Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
42 Dermatologic Agents Phase 3
43 Antipruritics Phase 2, Phase 3,Phase 3
44 Respiratory System Agents Phase 2,Not Applicable
45 Cromolyn Sodium Phase 2
46 Anti-Asthmatic Agents Phase 2,Not Applicable
47 Olive Nutraceutical Phase 1, Phase 2
48 Omega 3 Fatty Acid Nutraceutical Phase 1, Phase 2
49 Fumitory Nutraceutical Phase 2
50
gamma-Aminobutyric acid Approved, Investigational Not Applicable 56-12-2 119

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
2 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
3 Uremic Pruritus, Cytokines and Polymethylmethacrylate Artificial Kidney Completed NCT00442819 Phase 4
4 Comparative Study of the Efficacy of SARNA Sensitive Lotion for Treatment of Uremic Itch in Adult Hemodialysis Patients Completed NCT00693654 Phase 4 Sarna;Cetaphil
5 A Randomized-Withdrawal Phase 3 Study Evaluating the Safety and Efficacy of Oral Nalfurafine HCl (AC-820)in Subjects on Hemodialysis With Uremic Pruritus (Renal Itch) Unknown status NCT00793156 Phase 3 Nalfurafine HCl 2.5 µg;Nalfurafine HCl 5.0 µg
6 Combined Western and Traditional Chinese Medicine Daycare for CKD Patients Unknown status NCT02545036 Phase 3
7 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus Completed NCT02143648 Phase 2, Phase 3 nalbuphine HCl ER tablets 60 mg BID;nalbuphine HCl ER tablets 120mg BID;Placebo tablets BID
8 Open Label Extension Study of Nalbuphine HCl ER in Hemodialysis Patients With Uremic Pruritus Completed NCT02143973 Phase 2, Phase 3 nalbuphine HCl ER 60mg BID;nalbuphine HCl ER 90mg BID;nalbuphine HCl ER 120mg BID
9 Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Completed NCT02858726 Phase 2, Phase 3 CR845 0.5 mcg/kg;CR845 1 mcg/kg;CR845 1.5mcg/kg;Placebo
10 Efficacy, Local Tolerance and Patient Acceptability of a Moisturizing Emollient in Patients With Uremic Xerosis Completed NCT01084720 Phase 3 V0034 CR
11 A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Recruiting NCT03422653 Phase 3 CR845 0.5 mcg/kg;Placebo
12 Extension Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Recruiting NCT03281538 Phase 3 CR845
13 Treatment of Uremic Pruritus by Olive-omega 3 Ointment Unknown status NCT01447693 Phase 1, Phase 2
14 Treatment of Uremic Pruritus With PA101B Completed NCT02696499 Phase 2 PA101B;Placebo
15 Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pruritus Completed NCT02229929 Phase 2 Part A: Placebo;Part A: CR845 0.5 mcg/kg;Part A: CR845 1.0 mcg/kg;Part A: CR845 2.5 mcg/kg;Part B: Placebo;Part B: CR845 1.0 mcg/kg
16 Evaluating the Effect of Cromolyn Sodium in Uremic Pruritus Completed NCT00745199 Phase 2 cromolyn sodium;placebo
17 Evaluating the Effect of Fumaria Parviflora L. in Uremic Pruritus Completed NCT02671162 Phase 2 Wheat;Fumaria
18 A Study of SK-1405 in Hemodialysis Patients With Uremic Pruritus Recruiting NCT03218501 Phase 2 SK-1405 high dose;SK-1405 low dose;Placebo
19 Efficacy and Safety of MT-9938 for Treatment of Uremic Pruritus in Subjects With End-stage Renal Disease Receiving Hemodialysis Terminated NCT01660243 Phase 2 Nalfurafine hydrochloride(MT-9938) 2.5μg;Nalfurafine hydrochloride(MT-9938) 5μg;Nalfurafine hydrochloride(MT-9938) 10μg;Placebo
20 TRK-820 Study in Subjects on Hemodialysis With or Without Uremic Pruritus Completed NCT03002233 Phase 1 TRK-820
21 Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus Completed NCT02373215 Phase 1 Nalbuphine HCL ER
22 Efficacy of Calmmax Cream in the Management of Chronic Uremic Pruritus Unknown status NCT02032537 Not Applicable Callmax cream application over affected skin;Placebo
23 Gabapentin - A Solution to Uremic Pruritus? Unknown status NCT00577967 Not Applicable Gabapentin
24 Efficacy of Laser Acupuncture on Pruritus in Patients With Chronic Kidney Disease Undergoing Hemodialysis Unknown status NCT02432508 Not Applicable
25 An Observational Study of Pruritus Amongst Hemodialysis Patients Unknown status NCT00715260
26 Evaluating the Effect of Senna in Uremic Pruritus Completed NCT02008864 Not Applicable Senna;Placebo
27 Montelukast for Treatment of Uremic Pruritus Completed NCT02559388 Not Applicable Montelukast;placebo
28 The Effect of Phototherapy on Pruritus of Patients With Chronic Kidney Disease Completed NCT00494975 Not Applicable
29 Pruritus in Patients With Chronic Kidney Disease Completed NCT01727180
30 Gabapentin for Prophylaxis Intrathecal Morphine-Induced Pruritus Completed NCT01236859 Not Applicable Gabapentin
31 Safety and Efficacy of PG102P for Uremic Pruritus in HD Patients Recruiting NCT03576235 Not Applicable PG102P;Placebo

Search NIH Clinical Center for Uremic Pruritus

Genetic Tests for Uremic Pruritus

Anatomical Context for Uremic Pruritus

MalaCards organs/tissues related to Uremic Pruritus:

41
Kidney, Skin, Lymph Node

Publications for Uremic Pruritus

Articles related to Uremic Pruritus:

(show top 50) (show all 144)
# Title Authors Year
1
Uremic Pruritus is Associated with Two-Year Cardiovascular Mortality in Long Term Hemodialysis Patients. ( 29913453 )
2018
2
A Systematic Review and Meta-analysis of Using Acupuncture and Acupressure for Uremic Pruritus. ( 29507269 )
2018
3
UPLC-QTOF MS-Based Serum Metabolomic Profiling Analysis Reveals the Molecular Perturbations Underlying Uremic Pruritus. ( 29546058 )
2018
4
Uremic pruritus and associated factors in hemodialysis patients: A multi-center study. ( 29971209 )
2018
5
Gabapentin versus dexchlorpheniramine as treatment for uremic pruritus: a randomised controlled trial. ( 29976533 )
2018
6
The Effect of Increasing Blood Flow Rate on Severity of Uremic Pruritus in Hemodialysis Patients: A Single Clinical Trial. ( 29778130 )
2018
7
Pregabalin and Uremic Pruritus. ( 28717339 )
2017
8
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Nalbuphine ER Tablets for Uremic Pruritus. ( 29253847 )
2017
9
A controlled trial of narrowband ultraviolet B phototherapy for the treatment of uremic pruritus. ( 28164894 )
2017
10
Sleep Disorders, Restless Legs Syndrome, and Uremic Pruritus: Diagnosis and Treatment of Common Symptoms in DialysisA Patients. ( 27693261 )
2017
11
Therapeutic Effect of Montelukast for Treatment of Uremic Pruritus in Hemodialysis Patients. ( 28174353 )
2017
12
Uremic Pruritus: An Itch with Ominous Consequences. ( 29183013 )
2017
13
Sertraline can reduce the uremic pruritus in hemodialysis patient: A double blind randomized clinical trial from Southern Iran. ( 28263039 )
2017
14
Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 I1m. ( 28260912 )
2017
15
Blood lead level is a positive predictor of uremic pruritus in patients undergoing hemodialysis. ( 28652758 )
2017
16
Curative effect of neutral macroporous resin hemoperfusion on treating hemodialysis patients with refractory uremic pruritus. ( 28328802 )
2017
17
Treatment of Uremic Pruritus: A Systematic Review. ( 28720208 )
2017
18
Clinical interpretation of the Uremic Pruritus in Dialysis Patients (UP-Dial) scale: a novel instrument for the assessment of uremic pruritus. ( 28960570 )
2017
19
A Comparison of Uremic Pruritus in Patients Receiving Peritoneal Dialysis and Hemodialysis. ( 26945400 )
2016
20
Comparison of Gabapentin and Ketotifen in Treatment of Uremic Pruritus in Hemodialysis Patients. ( 27022338 )
2016
21
Gabapentin for uremic pruritus in hemodialysis patients: a qualitative systematic review. ( 27022475 )
2016
22
Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature. ( 27043168 )
2016
23
Targeting the Opioid Pathway for Uremic Pruritus: A Systematic Review and Meta-analysis. ( 28270926 )
2016
24
An Observational Longitudinal Study Investigating the Effectiveness of 75a88mg Pregabalin Post-Hemodialysis among Uremic Pruritus Patients. ( 27824127 )
2016
25
Loss of Papillary Dermal Calcitonin Gene Related Peptide-Expressing Neurons Significantly Correlates with Uremic Pruritus. ( 27448750 )
2016
26
Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene Polymorphisms. ( 27034934 )
2016
27
Acupressure and Transcutaneous Electrical Acupoint Stimulation for Improving Uremic Pruritus: A Randomized, Controlled Trial. ( 27228268 )
2016
28
Reply to: Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature. ( 27687138 )
2016
29
Environmental NO2 and CO Exposure: Ignored Factors Associated with Uremic Pruritus in Patients Undergoing Hemodialysis. ( 27507591 )
2016
30
Comparison of uremic pruritus between patients undergoing hemodialysis and peritoneal dialysis. ( 27366666 )
2016
31
Development of a Multidimensional Assessment Tool for Uremic Pruritus in Dialysis Patients (UP-Dial). ( 28012182 )
2016
32
Uremic pruritus treated successfully with the Goeckerman Program. ( 27617950 )
2016
33
Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial. ( 27397522 )
2016
34
Effect of Auricular Acupressure on Uremic Pruritus in Patients Receiving Hemodialysis Treatment: A Randomized Controlled Trial. ( 26495017 )
2015
35
Role of Interleukin-2 in Uremic Pruritus Among Attendants of AL-Zahraa Hospital Dialysis Unit. ( 25814728 )
2015
36
Comparison of Avena sativa, vinegar, and hydroxyzine for uremic pruritus of hemodialysis patients: a crossover randomized clinical trial. ( 26174460 )
2015
37
Safety of pregabalin among hemodialysis patients suffering from uremic pruritus. ( 26702255 )
2015
38
Is uremic pruritus still an important clinical problem in maintenance hemodialysis patients? ( 26616469 )
2015
39
Association of high-sensitive C-reactive protein and dialysis adequacy with uremic pruritus. ( 26354559 )
2015
40
Uremic pruritus. ( 24402092 )
2014
41
Quiz page August 2014: pruritus in a dialysis patient. Mycosis fungoides (folliculotropic variant) in a dialysis patient, with rare presentation of persistent generalized pruritus with characteristics of uremic pruritus without skin lesions. ( 25060007 )
2014
42
Efficacy and Safety of Gabapentin for Uremic Pruritus and Restless Legs Syndrome in Conservatively Managed Patients With Chronic Kidney Disease. ( 25220049 )
2014
43
Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial. ( 24482090 )
2014
44
Uremic pruritus is improved by gabapentin. ( 24898738 )
2014
45
Uremic pruritus pathogenesis, revisited. ( 25366503 )
2014
46
Interleukin-31 is associated with uremic pruritus in patients receiving hemodialysis. ( 25270263 )
2014
47
Effective treatment of uremic pruritus and acquired perforating dermatosis with amitriptyline. ( 23425115 )
2013
48
Longitudinal predictors of uremic pruritus. ( 24209894 )
2013
49
Uremic pruritus, dialysis adequacy, and metabolic profiles in hemodialysis patients: a prospective 5-year cohort study. ( 23940749 )
2013
50
Effect of acupressure on patients in Turkey receiving hemodialysis treatment for uremic pruritus. ( 23981400 )
2013

Variations for Uremic Pruritus

Expression for Uremic Pruritus

Search GEO for disease gene expression data for Uremic Pruritus.

Pathways for Uremic Pruritus

Pathways related to Uremic Pruritus according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 IL18 IL1B IL2 IL31 IL6
2
Show member pathways
12.82 IL18 IL1B IL2 IL6
3
Show member pathways
12.69 IL18 IL1B IL2 IL6
4
Show member pathways
12.59 IL18 IL1B IL2 IL6
5
Show member pathways
12.41 IL18 IL1B IL2 IL6
6
Show member pathways
12.4 IL18 IL1B IL2 IL6
7
Show member pathways
12.25 IL1B IL2 IL6
8
Show member pathways
12.2 IL18 IL1B IL2 IL6
9 12.06 IL18 IL1B IL6
10
Show member pathways
12.05 IL18 IL1B IL6
11
Show member pathways
12.04 CRP IL1B IL2 IL6
12
Show member pathways
12.03 IL1B IL2 IL6
13
Show member pathways
11.89 IL18 IL1B IL2 IL6
14 11.85 IL1B IL2 IL6
15
Show member pathways
11.83 IL18 IL1B IL2 IL6
16 11.82 IL18 IL1B IL6
17
Show member pathways
11.81 IL18 IL1B IL2
18 11.69 IL18 IL1B IL6
19 11.66 IL18 IL1B IL6
20 11.6 IL18 IL1B IL2
21 11.54 IL1B IL2 IL6
22
Show member pathways
11.43 IL1B IL2 IL6
23 11.35 IL18 IL1B IL6
24 11.29 IL18 IL1B
25 11.23 IL18 IL1B IL6
26 11.21 IL1B IL6
27 11.2 IL1B IL6
28 11.19 IL18 IL1B IL6
29 11.15 IL1B IL6
30 11.09 IL18 IL2
31 11.04 IL18 IL1B
32 10.97 IL18 IL1B
33 10.89 CRP IL6
34 10.88 IL18 IL1B IL6
35 10.64 IL18 IL1B IL6
36 10.38 IL18 IL1B
37 10.28 IL1B IL2 IL6

GO Terms for Uremic Pruritus

Cellular components related to Uremic Pruritus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CRP IL18 IL1B IL2 IL31 IL6
2 extracellular space GO:0005615 9.1 CRP IL18 IL1B IL2 IL31 IL6

Biological processes related to Uremic Pruritus according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 CRP IL18 IL1B IL6
2 positive regulation of gene expression GO:0010628 9.81 CRP IL18 IL1B IL6
3 MAPK cascade GO:0000165 9.8 IL18 IL1B IL2
4 response to ethanol GO:0045471 9.7 CNR1 IL2 OPRK1
5 response to cocaine GO:0042220 9.62 CNR1 OPRK1
6 acute-phase response GO:0006953 9.61 CRP IL6
7 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.61 IL1B IL2
8 lipopolysaccharide-mediated signaling pathway GO:0031663 9.6 IL18 IL1B
9 response to morphine GO:0043278 9.59 CNR1 OPRK1
10 positive regulation of activated T cell proliferation GO:0042104 9.58 IL18 IL2
11 positive regulation of p38MAPK cascade GO:1900745 9.58 IL1B OPRK1
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IL18 IL2 IL6
13 natural killer cell activation GO:0030101 9.57 IL18 IL2
14 positive regulation of interleukin-17 production GO:0032740 9.56 IL18 IL2
15 immune response GO:0006955 9.55 IL18 IL1B IL2 IL6 OPRK1
16 positive regulation of immunoglobulin secretion GO:0051024 9.54 IL2 IL6
17 positive regulation of T cell proliferation GO:0042102 9.5 IL1B IL2 IL6
18 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.49 IL18 IL1B
19 negative regulation of lipid storage GO:0010888 9.48 CRP IL6
20 interleukin-6 production GO:0032635 9.46 IL18 IL1B
21 positive regulation of tissue remodeling GO:0034105 9.43 IL18 IL2
22 positive regulation of interferon-gamma production GO:0032729 9.43 IL18 IL1B IL2
23 positive regulation of fever generation GO:0031622 9.37 CNR1 IL1B
24 regulation of signaling receptor activity GO:0010469 9.35 IL18 IL1B IL2 IL31 IL6
25 cytokine-mediated signaling pathway GO:0019221 9.02 IL18 IL1B IL2 IL31 IL6

Molecular functions related to Uremic Pruritus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IL18 IL1B IL2 IL31 IL6

Sources for Uremic Pruritus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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