MCID: URM005
MIFTS: 39

Uremic Pruritus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Uremic Pruritus

MalaCards integrated aliases for Uremic Pruritus:

Name: Uremic Pruritus 58 71

Characteristics:

Orphanet epidemiological data:

58
uremic pruritus
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

UMLS via Orphanet 72 C1262019
Orphanet 58 ORPHA94059
UMLS 71 C1262019

Summaries for Uremic Pruritus

MalaCards based summary : Uremic Pruritus is related to end stage renal failure and lipid metabolism disorder. An important gene associated with Uremic Pruritus is CNR1 (Cannabinoid Receptor 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Measles. The drugs Pregabalin and Fexofenadine have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and bone, and related phenotype is homeostasis/metabolism.

Wikipedia : 74 Uremic pruritus is caused by chronic kidney failure and is the most common internal systemic cause of... more...

Related Diseases for Uremic Pruritus

Diseases related to Uremic Pruritus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 354)
# Related Disease Score Top Affiliating Genes
1 end stage renal failure 30.7 IL6 IL2 CRP
2 lipid metabolism disorder 29.8 IL6 CRP CNR1
3 leprosy 3 29.6 IL6 IL2 IL1B
4 viral hepatitis 29.5 SLC17A5 IL6 IL2 CRP
5 peripheral nervous system disease 29.4 IL6 IL2 IL1B CRP
6 proteasome-associated autoinflammatory syndrome 1 29.3 IL6 IL1B IL18 CRP
7 skin disease 29.1 IL6 IL31 IL2 IL18 CRP
8 contact dermatitis 28.6 IL6 IL31 IL2 IL1B IL18
9 chronic kidney disease 10.5
10 uremia 10.4
11 renal infectious disease 10.4 IL18 CRP
12 systemic onset juvenile idiopathic arthritis 10.3 IL1B IL18
13 hyperparathyroidism 10.3
14 kidney disease 10.3
15 cervical adenitis 10.3 IL1B CRP
16 gingival recession 10.3 IL1B CRP
17 secondary hyperparathyroidism 10.3
18 suppurative otitis media 10.3 IL1B CRP
19 subacute lymphocytic thyroiditis 10.3 IL2 CRP
20 paratyphoid fever 10.3 IL1B CRP
21 clostridium difficile colitis 10.3 IL1B CRP
22 kwashiorkor 10.2 SLC17A5 CRP
23 autoimmune vasculitis 10.2 IL2 IL1B
24 analbuminemia 10.2 SLC17A5 CRP
25 acute graft versus host disease 10.2 IL2 IL18
26 cyclic vomiting syndrome 10.2 IL6 CNR1
27 cold agglutinin disease 10.2 IL6 CRP
28 cardiogenic shock 10.2 IL6 CRP
29 cryopyrin-associated periodic syndrome 10.2 IL6 CRP
30 restless legs syndrome 10.2
31 systemic autoimmune disease 10.2 IL6 CRP
32 idiopathic hypercalciuria 10.2 SLC17A5 IL1B
33 pleural tuberculosis 10.2 IL2 IL18
34 generalized atherosclerosis 10.2 IL6 CRP
35 aortitis 10.2 IL6 CRP
36 hypopyon 10.2 IL6 CRP
37 acute cholangitis 10.2 IL6 CRP
38 tenosynovitis 10.1 IL6 CRP
39 pyuria 10.1 IL6 CRP
40 lung abscess 10.1 IL6 CRP
41 chlamydia pneumonia 10.1 IL6 CRP
42 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.1 IL6 CRP
43 polyclonal hypergammaglobulinemia 10.1 IL6 CRP
44 iritis 10.1 IL6 CRP
45 osteosclerotic myeloma 10.1 IL6 IL1B
46 periodontitis, chronic 10.1 IL6 IL1B
47 iridocyclitis 10.1 IL6 CRP
48 vaginal discharge 10.1 IL6 CRP
49 epididymis disease 10.1 IL6 CRP
50 neutrophilia, hereditary 10.1 IL6 CRP

Graphical network of the top 20 diseases related to Uremic Pruritus:



Diseases related to Uremic Pruritus

Symptoms & Phenotypes for Uremic Pruritus

MGI Mouse Phenotypes related to Uremic Pruritus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 CNR1 CRP IL18 IL1B IL2 IL6

Drugs & Therapeutics for Uremic Pruritus

Drugs for Uremic Pruritus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
2
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
3
Histamine Approved, Investigational Phase 4 51-45-6 774
4
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
5
Doxepin Approved, Investigational Phase 4 1668-19-5 667477 667468
6
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
7
Promethazine Approved, Investigational Phase 4 60-87-7 4927
8
Ethanol Approved Phase 4 64-17-5 702
9
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
10
Sodium citrate Approved, Investigational Phase 4 68-04-2
11
Petrolatum Approved, Investigational Phase 4 8009-03-8
12
Benzyl alcohol Approved Phase 4 100-51-6 244
13
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
14
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
15
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
16 Hormones Phase 4
17 Calcium, Dietary Phase 4
18 calcium channel blockers Phase 4
19 Histamine H1 Antagonists Phase 4
20 Histamine H1 Antagonists, Non-Sedating Phase 4
21 Anti-Allergic Agents Phase 4
22 Vasodilator Agents Phase 4
23 Polymethyl Methacrylate Phase 4
24 Protective Agents Phase 4
25 Central Nervous System Depressants Phase 4
26 Analgesics Phase 4
27 Tranquilizing Agents Phase 4
28 Anti-Anxiety Agents Phase 4
29 Neurotransmitter Agents Phase 4
30 Psychotropic Drugs Phase 4
31 Hypnotics and Sedatives Phase 4
32 Histamine Antagonists Phase 4
33 Anticonvulsants Phase 4
34 Antimanic Agents Phase 4
35
Histamine Phosphate Phase 4 51-74-1 65513
36 Antidepressive Agents Phase 4
37 Excitatory Amino Acid Antagonists Phase 4
38 Excitatory Amino Acids Phase 4
39 Antidepressive Agents, Tricyclic Phase 4
40 Anesthetics, Local Phase 4
41 Tocopherols Phase 4
42 Anesthetics Phase 4
43 Pramoxine Phase 4
44 Citrate Phase 4
45 Carbopol 940 Phase 4
46
Nalbuphine Approved Phase 2, Phase 3 20594-83-6 5360630 5311304
47 Narcotics Phase 2, Phase 3
48 Analgesics, Opioid Phase 2, Phase 3
49 Antipruritics Phase 2, Phase 3
50 Dermatologic Agents Phase 3

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
2 A Multicenter, Double-blind, Randomized, Placebo and Active-controlled Study of Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
3 Uremic Pruritus, Cytokines and Polymethylmethacrylate Artificial Kidney Completed NCT00442819 Phase 4
4 Comparison of Gabapentin With Doxepin in the Management of Uremic Pruritus: Pilot Study Completed NCT03758079 Phase 4 Doxepin;Gabapentin
5 A Controlled Comparative Study of the Efficacy of SARNA Sensitive Lotion for Treatment of Uremic Pruritus in Adult Hemodialysis Patients Completed NCT00693654 Phase 4 Sarna;Cetaphil
6 A Randomized-Withdrawal Phase 3 Study Evaluation the Safety and Efficacy of Oral Nalfurafine HCl (AC-820)in Subjects on Hemodialysis With Uremic Pruritus (Renal Itch) Unknown status NCT00793156 Phase 3 Nalfurafine HCl 2.5 µg;Nalfurafine HCl 5.0 µg
7 Clinical Study of Combined Western Medicine and Traditional Chinese Medicine Daycare Model for Chronic Kidney Disease Patients Unknown status NCT02545036 Phase 3
8 An Open Label Extension Study of the Safety and Anti-Pruritic Efficacy of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus Completed NCT02143973 Phase 2, Phase 3 nalbuphine HCl ER 60mg BID;nalbuphine HCl ER 90mg BID;nalbuphine HCl ER 120mg BID
9 A Randomized, Double-Blind, Placebo-Controlled, Parallel, 3-Arm Study of the Safety and Anti-Pruritic Efficacy of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus Completed NCT02143648 Phase 2, Phase 3 nalbuphine HCl ER tablets 60 mg BID;nalbuphine HCl ER tablets 120mg BID;Placebo tablets BID
10 Efficacy, Local Tolerance and Patient Acceptability of a Moisturizing Emollient in Patients Undergoing Maintenance Renal Dialysis With Uremic Xerosis (MRD) Completed NCT01084720 Phase 3 V0034 CR
11 A Two-Part, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Intravenous CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Completed NCT02858726 Phase 2, Phase 3 CR845 0.5 mcg/kg;CR845 1 mcg/kg;CR845 1.5mcg/kg;Placebo
12 A Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Safety and Efficacy of Intravenous CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus, With a 52-Week Open Label Extension Recruiting NCT03636269 Phase 3 CR845 0.5 mcg/kg;Placebo
13 An Open-Label, Multicenter Study to Evaluate the Safety and Effectiveness of Intravenous CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Recruiting NCT03998163 Phase 3 CR845 0.5 mcg/kg
14 A Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Safety and Efficacy of Intravenous CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus, With a 52-Week Open Label Extension Active, not recruiting NCT03422653 Phase 3 CR845 0.5 mcg/kg;Placebo
15 An Open-Label, Multicenter, Extension Study to Evaluate the Long Term Safety of Intravenous CR845 in Hemodialysis Patients With Chronic Kidney Disease-Associated Pruritus Active, not recruiting NCT03281538 Phase 3 CR845
16 Treatment of Uremic Pruritus by Olive-omega 3 Ointment Unknown status NCT01447693 Phase 1, Phase 2
17 A Phase II, Double-Blind, Randomized, Placebo-Controlled Study of SK-1405 in Hemodialysis Patients With Uremic Pruritus Completed NCT03218501 Phase 2 SK-1405 high dose;SK-1405 low dose;Placebo
18 Evaluation the Effect of Fumaria Parviflora L. on Uremic Pruritus of End-stage Renal Disease Patients: A Randomized Double- Blind Placebo-controlled Clinical Trial Completed NCT02671162 Phase 2 Wheat;Fumaria
19 Treatment of Uremic Pruritus With Inhaled PA101B in Patients With End-Stage Renal Disease Requiring Hemodialysis Completed NCT02696499 Phase 2 PA101B;Placebo
20 Phase II Study of the Effect of Oral Cromolyn Sodium on Uremic Pruritus and Serum Tryptase Levels of Hemodialysed Patients Completed NCT00745199 Phase 2 cromolyn sodium;placebo
21 A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety and Pharmacokinetics of Intravenous CR845 in Hemodialysis Patients, and Its Safety and Efficacy in Hemodialysis Patients With Uremic Pruritus Completed NCT02229929 Phase 2 Part A: Placebo;Part A: CR845 0.5 mcg/kg;Part A: CR845 1.0 mcg/kg;Part A: CR845 2.5 mcg/kg;Part B: Placebo;Part B: CR845 1.0 mcg/kg
22 A Phase II Clinical Study of MR13A9 in Hemodialysis Patients With Pruritus. Active, not recruiting NCT03802617 Phase 2 MR13A9;Placebo
23 A Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus Active, not recruiting NCT03617536 Phase 2 CR845 0.25 mg Oral Tablet;CR845 0.5 mg Oral Tablet;CR845 1 mg Oral Tablet;Placebo Oral Tablet
24 A Phase 2, Randomized, Double-blind, Placebo-controlled, Fixed-dose, Parallel-group, Multicenter, Efficacy, and Safety Study of MT-9938 for Treatment of Uremic Pruritus in Subjects With End-stage Renal Disease Receiving Hemodialysis Terminated NCT01660243 Phase 2 Nalfurafine hydrochloride(MT-9938) 2.5μg;Nalfurafine hydrochloride(MT-9938) 5μg;Nalfurafine hydrochloride(MT-9938) 10μg;Placebo
25 A Phase 1 Study to Observe Safety and Tolerability of Single and Multiple Doses of TRK-820 in Subjects on Hemodialysis and to Observe the Effect on Uremic Pruritus Completed NCT03002233 Phase 1 TRK-820
26 A Phase 1, Open-Label, Non-Randomized, Parallel-Group Study to Characterize and Compare the Pharmacokinetics, Safety, and Tolerability of Escalating Oral Doses of Nalbuphine Hydrochloride Extended Release Tablets in End-Stage Renal Disease Patients on Hemodialysis and Matched Healthy Control Subjects Completed NCT02373215 Phase 1 Nalbuphine HCL ER
27 Gabapentin - A Solution to Uremic Pruritus? A Prospective, Randomized, Placebo-controlled, Double-blind Study Unknown status NCT00577967 Gabapentin
28 Efficacy of Laser Acupuncture on Pruritus in Patients With Chronic Kidney Disease Undergoing Hemodialysis: A Multiple Centers, Randomized, Assessor- and Participant-blind, Controlled, Cross-over Clinical Trial Unknown status NCT02432508
29 Efficacy of Calmmax Cream in the Management of Chronic Uremic Pruritus Unknown status NCT02032537 Callmax cream application over affected skin;Placebo
30 A Multicenter, Prospective, Observational Study of Pruritus Amongst Hemodialysis Patients: The ITCH National Registry Unknown status NCT00715260
31 Phase II Study of the Effect of Senna Alexandrina Mill. on Uremic Pruritus and Serum IL-2, INF-δ and TNF-α Levels of Hemodialysed Patients Completed NCT02008864 Senna;Placebo
32 Safety and Efficacy of PG102P for the coNtrol of prUritus in Patients underGoing Hemodialysis (SNUG Trial): Study Protocol for a Randomized Control Trial Completed NCT03576235 PG102P;Placebo
33 Pruritus in Patients With Chronic Kidney Disease Completed NCT01727180
34 The Effect of Phototherapy on Pruritus of Patients With Chronic Kidney Disease Completed NCT00494975
35 Effect of Turmeric on Pruritus in Hemodialysis Patients Completed NCT01037595 Early Phase 1 turmeric;placebo;turmeric
36 Assessment of Montelukast Efficacy in the Treatment of Refractive Uremic Pruritus Completed NCT02559388 Montelukast;placebo
37 Gabapentin for Prophylaxis Intrathecal Morphine-Induced Pruritus After Orthopedics Surgery Completed NCT01236859 Gabapentin
38 Using of the Skin as a Third Spare Kidney for Patients With Chronic Renal Failure Not yet recruiting NCT03810989
39 Klotho and Fibroblast Growth Factor 23 in Chronic Kidney Disease-associated Pruritus and Their Response to Narrowband Ultraviolet B Not yet recruiting NCT03532568

Search NIH Clinical Center for Uremic Pruritus

Genetic Tests for Uremic Pruritus

Anatomical Context for Uremic Pruritus

MalaCards organs/tissues related to Uremic Pruritus:

40
Kidney, Skin, Bone, Liver, Lung, Thyroid, Lymph Node

Publications for Uremic Pruritus

Articles related to Uremic Pruritus:

(show top 50) (show all 271)
# Title Authors PMID Year
1
Development and Validation of a Uremic Pruritus Treatment Algorithm and Patient Information Toolkit in Patients With Chronic Kidney Disease and End Stage Kidney Disease. 61
31610269 2020
2
Charcoal for the management of pruritus and uremic toxins in patients with chronic kidney disease. 61
31725009 2020
3
Skin Cutibacterium acnes Mediates Fermentation to Suppress the Calcium Phosphate-Induced Itching: A Butyric Acid Derivative with Potential for Uremic Pruritus. 61
31979095 2020
4
Cannabinoids for the Treatment of Chronic Pruritus: A Review. 61
31987788 2020
5
Difelikefalin for the Treatment of Uremic Pruritus. 61
31940704 2020
6
Factors Associated with Uremic Pruritus in Patients Undergoing Peritoneal Dialysis. 61
32021382 2020
7
Association between Uremic Pruritus and Long-Term Outcomes in Patients Undergoing Dialysis. 61
31940463 2020
8
Itch and Ache on Dialysis: New Approaches to Manage Uremic Pruritus and Restless Legs. 61
31851986 2019
9
Bioactive: A new era of bioactive ingredients in topical formulations for inflammatory dermatoses. 61
31583790 2019
10
Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine. 61
31492823 2019
11
IL-6/p-BTK/p-ERK signaling mediates calcium phosphate-induced pruritus. 61
31365830 2019
12
Gabapentin for uremic pruritus: a systematic review of randomized controlled trials. 61
31777066 2019
13
Randomized trial of two after-dialysis gabapentin regimens for severe uremic pruritus in hemodialysis patients. 61
31494816 2019
14
Safety and efficacy of PG102P for the control of pruritus in patients undergoing hemodialysis (SNUG trial): study protocol for a randomized controlled trial. 61
31779697 2019
15
Reasons for Underreporting of Uremic Pruritus in People With Chronic Kidney Disease: A Qualitative Study. 61
31228535 2019
16
The effect of massage and topical violet oil on the severity of pruritus and dry skin in hemodialysis patients: A randomized controlled trial. 61
31331569 2019
17
Pruritus Associated With Chronic Kidney Disease: A Comprehensive Literature Review. 61
31572641 2019
18
Uremic Pruritus: Prevalence and Impact on Quality of Life and Depressive Symptoms in Hemodialysis Patients. 61
31565588 2019
19
Chronic Pruritus Responding to Dupilumab-A Case Series. 61
31261951 2019
20
Chinese herbal bath therapy for the treatment of uremic pruritus: meta-analysis of randomized controlled trials. 61
31077221 2019
21
A successful case of dupilumab treatment for severe uremic pruritus. 61
30993160 2019
22
Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1. 61
30588658 2019
23
Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review. 61
30484835 2019
24
Multidimensional pruritus assessment in hemodialysis patients. 61
30727999 2019
25
Insulin Resistance and Hepatitis C Virus-Associated Subclinical Inflammation Are Hidden Causes of Pruritus in Egyptian Hemodialysis Patients: A Multicenter Prospective Observational Study. 61
31311030 2019
26
Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients. 61
30799944 2019
27
Prevalence and Severity of Itching in Patients with End-Stage Renal Disease: Treatment with Nalfurafine Hydrochloride. 61
30943482 2019
28
Restless legs syndrome in end-stage renal disease patients undergoing hemodialysis. 61
30698206 2018
29
Vegetarian diet may ameliorate uremic pruritus in hemodialysis patients. 61
30396306 2018
30
Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients. 61
30467375 2018
31
Treatments of uremic pruritus: A systematic review. 61
30141218 2018
32
Role of narrow band ultra violet radiation as an add-on therapy in peritoneal dialysis patients with refractory uremic pruritus. 61
30090706 2018
33
Gabapentin versus dexchlorpheniramine as treatment for uremic pruritus: a randomised controlled trial. 61
29976533 2018
34
Clinical interpretation of the Uremic Pruritus in Dialysis Patients (UP-Dial) scale: a novel instrument for the assessment of uremic pruritus. 61
28960570 2018
35
Drugs on the Horizon for Chronic Pruritus. 61
29929605 2018
36
Uremic pruritus and associated factors in hemodialysis patients: A multi-center study. 61
29971209 2018
37
The Effect of Increasing Blood Flow Rate on Severity of Uremic Pruritus in Hemodialysis Patients: A Single Clinical Trial. 61
29778130 2018
38
Does nalbuphine have a niche in managing pain? 61
29733100 2018
39
A Systematic Review and Meta-analysis of Using Acupuncture and Acupressure for Uremic Pruritus. 61
29507269 2018
40
Acupuncture Application in Chronic Kidney Disease and its Potential Mechanisms. 61
30286626 2018
41
Sertraline can reduce uremic pruritus in hemodialysis patient: A double blind randomized clinical trial from Southern Iran. 61
28263039 2018
42
UPLC-QTOF MS-Based Serum Metabolomic Profiling Analysis Reveals the Molecular Perturbations Underlying Uremic Pruritus. 61
29546058 2018
43
Dissociable effects of the kappa opioid receptor agonist nalfurafine on pain/itch-stimulated and pain/itch-depressed behaviors in male rats. 61
29063139 2018
44
Prognostic importance and determinants of uremic pruritus in patients receiving peritoneal dialysis: A prospective cohort study. 61
30183756 2018
45
Uremic Pruritus is Associated with Two-Year Cardiovascular Mortality in Long Term Hemodialysis Patients. 61
29913453 2018
46
International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis. 61
28923831 2017
47
Use of oral antidepressants in patients with chronic pruritus: A systematic review. 61
29033248 2017
48
Interleukin 31 and skin diseases: A systematic review. 61
29046191 2017
49
Treatment of Uremic Pruritus: A Systematic Review. 61
28720208 2017
50
β2-Microglobulin elicits itch-related responses in mice through the direct activation of primary afferent neurons expressing transient receptor potential vanilloid 1. 61
28687195 2017

Variations for Uremic Pruritus

Expression for Uremic Pruritus

Search GEO for disease gene expression data for Uremic Pruritus.

Pathways for Uremic Pruritus

Pathways related to Uremic Pruritus according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 IL6 IL31 IL2 IL1B IL18
2
Show member pathways
12.62 IL6 IL2 IL1B IL18
3
Show member pathways
12.41 IL6 IL2 IL1B IL18
4
Show member pathways
12.39 IL6 IL2 IL1B IL18
5
Show member pathways
12.18 IL6 IL2 IL18
6 12.14 IL6 IL1B IL18
7 12.08 IL6 IL1B IL18
8
Show member pathways
12.08 IL6 IL2 IL1B IL18
9 12.07 IL6 IL1B IL18
10
Show member pathways
12.07 IL6 IL2 IL1B CRP
11
Show member pathways
12.05 IL6 IL1B IL18
12
Show member pathways
12.04 IL6 IL2 IL1B
13 11.86 IL6 IL2 IL1B
14 11.83 IL6 IL1B IL18
15
Show member pathways
11.82 IL2 IL1B IL18
16 11.73 IL6 IL1B IL18
17 11.62 IL6 IL1B IL18
18 11.6 IL2 IL1B IL18
19
Show member pathways
11.57 IL6 IL2 IL1B IL18
20 11.56 IL6 IL2 IL1B
21
Show member pathways
11.47 IL6 IL2 IL1B
22 11.41 IL6 IL1B IL18
23 11.34 IL6 IL2 IL1B IL18
24 11.33 IL6 IL1B IL18
25 11.27 IL6 IL1B IL18
26 11.16 IL6 IL1B
27 11.11 IL2 IL18
28 11.11 IL6 IL1B IL18
29 11.05 IL1B IL18
30 11 IL6 IL1B IL18
31 10.98 IL1B IL18
32 10.9 IL6 CRP
33 10.9 IL6 IL2 IL1B
34 10.83 IL6 IL2 IL1B IL18
35 10.78 IL6 IL2 IL1B IL18
36 10.39 IL1B IL18

GO Terms for Uremic Pruritus

Cellular components related to Uremic Pruritus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 IL6 IL31 IL2 IL1B IL18 CRP
2 extracellular space GO:0005615 9.1 IL6 IL31 IL2 IL1B IL18 CRP

Biological processes related to Uremic Pruritus according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.87 IL6 IL1B IL18 CRP
2 inflammatory response GO:0006954 9.83 IL6 IL1B IL18 CRP
3 cell-cell signaling GO:0007267 9.79 IL2 IL1B IL18
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.75 IL6 IL1B IL18
5 positive regulation of inflammatory response GO:0050729 9.67 IL2 IL1B IL18
6 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 IL1B IL18
7 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.62 IL2 IL1B
8 positive regulation of vascular endothelial growth factor production GO:0010575 9.61 IL6 IL1B
9 negative regulation of neurogenesis GO:0050768 9.61 IL6 IL1B
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 IL6 IL2 IL18
11 positive regulation of activated T cell proliferation GO:0042104 9.6 IL2 IL18
12 natural killer cell activation GO:0030101 9.59 IL2 IL18
13 positive regulation of glial cell proliferation GO:0060252 9.58 IL6 IL1B
14 positive regulation of interleukin-17 production GO:0032740 9.56 IL2 IL18
15 positive regulation of immunoglobulin secretion GO:0051024 9.55 IL6 IL2
16 immune response GO:0006955 9.55 OPRK1 IL6 IL2 IL1B IL18
17 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.54 IL1B IL18
18 negative regulation of lipid storage GO:0010888 9.51 IL6 CRP
19 positive regulation of T cell proliferation GO:0042102 9.5 IL6 IL2 IL1B
20 interleukin-6 production GO:0032635 9.48 IL1B IL18
21 positive regulation of tissue remodeling GO:0034105 9.46 IL2 IL18
22 positive regulation of interferon-gamma production GO:0032729 9.43 IL2 IL1B IL18
23 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.4 IL1B IL18
24 positive regulation of fever generation GO:0031622 9.37 IL1B CNR1
25 cytokine-mediated signaling pathway GO:0019221 9.35 IL6 IL31 IL2 IL1B IL18
26 positive regulation of neuroinflammatory response GO:0150078 8.8 IL6 IL1B IL18

Molecular functions related to Uremic Pruritus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IL6 IL31 IL2 IL1B IL18

Sources for Uremic Pruritus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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