MCID: URM005
MIFTS: 37

Uremic Pruritus

Categories: Rare diseases

Aliases & Classifications for Uremic Pruritus

MalaCards integrated aliases for Uremic Pruritus:

Name: Uremic Pruritus 60 74

Characteristics:

Orphanet epidemiological data:

60
uremic pruritus
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

UMLS via Orphanet 75 C1262019
Orphanet 60 ORPHA94059
UMLS 74 C1262019

Summaries for Uremic Pruritus

MalaCards based summary : Uremic Pruritus is related to pleurisy and pericoronitis. An important gene associated with Uremic Pruritus is CRP (C-Reactive Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. Affiliated tissues include kidney, lymph node and skin, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 77 Uremic pruritus is caused by chronic kidney failure and is the most common internal systemic cause of... more...

Related Diseases for Uremic Pruritus

Diseases related to Uremic Pruritus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 pleurisy 10.4 CRP IL2
2 pericoronitis 10.3 CRP IL1B
3 suppurative otitis media 10.2 CRP IL1B
4 intermittent claudication 10.2 CRP IL6
5 hemorrhagic fever with renal syndrome 10.2 CRP IL6
6 collagen disease 10.2 CRP IL6
7 analbuminemia 10.2 CRP SLC17A5
8 autoimmune vasculitis 10.2 IL1B IL2
9 pain agnosia 10.2 CNR1 OPRK1
10 crohn's colitis 10.2 IL1B IL2
11 agnosia 10.2 CNR1 OPRK1
12 paracoccidioidomycosis 10.2 IL2 IL6
13 pharyngitis 10.2 CRP IL1B
14 cold agglutinin disease 10.2 CRP IL6
15 muckle-wells syndrome 10.2 CRP IL1B
16 cryopyrin-associated periodic syndrome 10.2 CRP IL6
17 acute cholangitis 10.2 CRP IL6
18 neutrophilia, hereditary 10.2 CRP IL6
19 spinal disease 10.2 CRP IL6
20 cyclic vomiting syndrome 10.2 CNR1 IL6
21 viral pneumonia 10.2 CRP IL6
22 multicentric castleman disease 10.2 CRP IL6
23 castleman disease 10.2 CRP IL6
24 relapsing polychondritis 10.2 CRP IL6
25 subacute thyroiditis 10.2 CRP IL6
26 intussusception 10.2 CRP IL6
27 louse-borne relapsing fever 10.2 CRP IL6
28 cecal disease 10.2 CRP IL6
29 streptococcal toxic-shock syndrome 10.2 IL2 IL6
30 extramedullary plasmacytoma 10.2 IL2 IL6
31 pyelitis 10.2 CRP IL6
32 ischemic heart disease 10.2 CRP IL6
33 mesenteric lymphadenitis 10.2 CRP IL6
34 meningoencephalitis 10.2 IL6 SLC17A5
35 viral meningitis 10.2 CRP IL6
36 hypersensitivity reaction type iii disease 10.2 CRP IL6
37 capillary leak syndrome 10.2 IL2 IL6
38 intermittent explosive disorder 10.2 CRP IL6
39 intermediate coronary syndrome 10.1 CRP IL6
40 burning mouth syndrome 10.1 IL2 IL6
41 fascioliasis 10.1 IL1B SLC17A5
42 systolic heart failure 10.1 CRP IL6
43 prediabetes syndrome 10.1 CRP IL6
44 intermediate uveitis 10.1 IL2 IL6
45 posterior uveitis 10.1 IL2 IL6
46 palindromic rheumatism 10.1 CRP IL1B
47 acute pyelonephritis 10.1 CRP IL6
48 bacterial vaginosis 10.1 IL1B IL6
49 apnea, obstructive sleep 10.1 CRP IL6
50 hematopoietic stem cell transplantation 10.1 IL2 IL6

Graphical network of the top 20 diseases related to Uremic Pruritus:



Diseases related to Uremic Pruritus

Symptoms & Phenotypes for Uremic Pruritus

MGI Mouse Phenotypes related to Uremic Pruritus:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 CNR1 IL18 IL2 IL6 OPRK1
2 homeostasis/metabolism MP:0005376 9.23 CNR1 CRP IL18 IL1B IL2 IL6

Drugs & Therapeutics for Uremic Pruritus

Search Clinical Trials , NIH Clinical Center for Uremic Pruritus

Genetic Tests for Uremic Pruritus

Anatomical Context for Uremic Pruritus

MalaCards organs/tissues related to Uremic Pruritus:

42
Kidney, Lymph Node, Skin, Thyroid, T Cells, Tonsil

Publications for Uremic Pruritus

Articles related to Uremic Pruritus:

(show top 50) (show all 153)
# Title Authors Year
1
Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients. ( 30799944 )
2019
2
A successful case of dupilumab treatment for severe uremic pruritus. ( 30993160 )
2019
3
Chinese herbal bath therapy for the treatment of uremic pruritus: meta-analysis of randomized controlled trials. ( 31077221 )
2019
4
A Systematic Review and Meta-analysis of Using Acupuncture and Acupressure for Uremic Pruritus. ( 29507269 )
2018
5
UPLC-QTOF MS-Based Serum Metabolomic Profiling Analysis Reveals the Molecular Perturbations Underlying Uremic Pruritus. ( 29546058 )
2018
6
The Effect of Increasing Blood Flow Rate on Severity of Uremic Pruritus in Hemodialysis Patients: A Single Clinical Trial. ( 29778130 )
2018
7
Uremic Pruritus is Associated with Two-Year Cardiovascular Mortality in Long Term Hemodialysis Patients. ( 29913453 )
2018
8
Uremic pruritus and associated factors in hemodialysis patients: A multi-center study. ( 29971209 )
2018
9
Gabapentin versus dexchlorpheniramine as treatment for uremic pruritus: a randomised controlled trial. ( 29976533 )
2018
10
Role of narrow band ultra violet radiation as an add-on therapy in peritoneal dialysis patients with refractory uremic pruritus. ( 30090706 )
2018
11
Treatments of uremic pruritus: A systematic review. ( 30141218 )
2018
12
Prognostic importance and determinants of uremic pruritus in patients receiving peritoneal dialysis: A prospective cohort study. ( 30183756 )
2018
13
Vegetarian diet may ameliorate uremic pruritus in hemodialysis patients. ( 30396306 )
2018
14
Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients. ( 30467375 )
2018
15
Sertraline can reduce uremic pruritus in hemodialysis patient: A double blind randomized clinical trial from Southern Iran. ( 28263039 )
2018
16
Clinical interpretation of the Uremic Pruritus in Dialysis Patients (UP-Dial) scale: a novel instrument for the assessment of uremic pruritus. ( 28960570 )
2018
17
Sleep Disorders, Restless Legs Syndrome, and Uremic Pruritus: Diagnosis and Treatment of Common Symptoms in Dialysis Patients. ( 27693261 )
2017
18
Uremic Pruritus: An Itch with Ominous Consequences. ( 29183013 )
2017
19
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Nalbuphine ER Tablets for Uremic Pruritus. ( 29253847 )
2017
20
Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial. ( 27397522 )
2017
21
Reply to: Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature. ( 27687138 )
2017
22
A controlled trial of narrowband ultraviolet B phototherapy for the treatment of uremic pruritus. ( 28164894 )
2017
23
Therapeutic Effect of Montelukast for Treatment of Uremic Pruritus in Hemodialysis Patients. ( 28174353 )
2017
24
Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm. ( 28260912 )
2017
25
Curative effect of neutral macroporous resin hemoperfusion on treating hemodialysis patients with refractory uremic pruritus. ( 28328802 )
2017
26
Blood lead level is a positive predictor of uremic pruritus in patients undergoing hemodialysis. ( 28652758 )
2017
27
Pregabalin and Uremic Pruritus. ( 28717339 )
2017
28
Treatment of Uremic Pruritus: A Systematic Review. ( 28720208 )
2017
29
Is uremic pruritus still an important clinical problem in maintenance hemodialysis patients? ( 26616469 )
2016
30
A Comparison of Uremic Pruritus in Patients Receiving Peritoneal Dialysis and Hemodialysis. ( 26945400 )
2016
31
Comparison of Gabapentin and Ketotifen in Treatment of Uremic Pruritus in Hemodialysis Patients. ( 27022338 )
2016
32
Gabapentin for uremic pruritus in hemodialysis patients: a qualitative systematic review. ( 27022475 )
2016
33
Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene Polymorphisms. ( 27034934 )
2016
34
Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature. ( 27043168 )
2016
35
Acupressure and Transcutaneous Electrical Acupoint Stimulation for Improving Uremic Pruritus: A Randomized, Controlled Trial. ( 27228268 )
2016
36
Comparison of uremic pruritus between patients undergoing hemodialysis and peritoneal dialysis. ( 27366666 )
2016
37
Loss of Papillary Dermal Calcitonin Gene Related Peptide-Expressing Neurons Significantly Correlates with Uremic Pruritus. ( 27448750 )
2016
38
Environmental NO2 and CO Exposure: Ignored Factors Associated with Uremic Pruritus in Patients Undergoing Hemodialysis. ( 27507591 )
2016
39
Uremic pruritus treated successfully with the Goeckerman Program. ( 27617950 )
2016
40
An Observational Longitudinal Study Investigating the Effectiveness of 75 mg Pregabalin Post-Hemodialysis among Uremic Pruritus Patients. ( 27824127 )
2016
41
Targeting the Opioid Pathway for Uremic Pruritus: A Systematic Review and Meta-analysis. ( 28270926 )
2016
42
Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease. ( 25220049 )
2015
43
Uremic pruritus. ( 24402092 )
2015
44
Role of Interleukin-2 in Uremic Pruritus Among Attendants of AL-Zahraa Hospital Dialysis Unit. ( 25814728 )
2015
45
Comparison of Avena sativa, vinegar, and hydroxyzine for uremic pruritus of hemodialysis patients: a crossover randomized clinical trial. ( 26174460 )
2015
46
Association of high-sensitive C-reactive protein and dialysis adequacy with uremic pruritus. ( 26354559 )
2015
47
Effect of Auricular Acupressure on Uremic Pruritus in Patients Receiving Hemodialysis Treatment: A Randomized Controlled Trial. ( 26495017 )
2015
48
Safety of pregabalin among hemodialysis patients suffering from uremic pruritus. ( 26702255 )
2015
49
Quiz page August 2014: pruritus in a dialysis patient. Mycosis fungoides (folliculotropic variant) in a dialysis patient, with rare presentation of persistent generalized pruritus with characteristics of uremic pruritus without skin lesions. ( 25060007 )
2014
50
Effective treatment of uremic pruritus and acquired perforating dermatosis with amitriptyline. ( 23425115 )
2014

Variations for Uremic Pruritus

Expression for Uremic Pruritus

Search GEO for disease gene expression data for Uremic Pruritus.

Pathways for Uremic Pruritus

Pathways related to Uremic Pruritus according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 IL18 IL1B IL2 IL31 IL6
2
Show member pathways
12.9 IL18 IL1B IL2 IL6
3
Show member pathways
12.7 IL18 IL1B IL2 IL6
4
Show member pathways
12.42 IL18 IL1B IL2 IL6
5
Show member pathways
12.4 IL18 IL1B IL2 IL6
6
Show member pathways
12.39 IL1B IL2 IL6
7
Show member pathways
12.09 IL18 IL1B IL2 IL6
8
Show member pathways
12.09 CRP IL1B IL2 IL6
9 12.07 IL18 IL1B IL6
10
Show member pathways
12.05 IL18 IL1B IL6
11
Show member pathways
12.04 IL1B IL2 IL6
12
Show member pathways
11.91 IL18 IL1B IL2 IL6
13 11.87 IL1B IL2 IL6
14 11.84 IL18 IL1B IL6
15
Show member pathways
11.83 IL18 IL1B IL2
16 11.69 IL18 IL1B IL6
17 11.66 IL18 IL1B IL6
18 11.6 IL18 IL1B IL2
19 11.56 IL1B IL2 IL6
20
Show member pathways
11.47 IL1B IL2 IL6
21 11.39 IL18 IL1B IL6
22
Show member pathways
11.37 IL18 IL1B IL2 IL6
23 11.3 IL18 IL1B IL6
24 11.29 IL18 IL1B
25 11.27 IL18 IL1B IL6
26 11.22 IL1B IL6
27 11.21 IL1B IL6
28 11.15 IL1B IL6
29 11.11 IL18 IL2
30 11.07 IL18 IL1B IL6
31 11.05 IL18 IL1B
32 10.98 IL18 IL1B
33 10.94 IL18 IL1B IL6
34 10.9 CRP IL6
35 10.9 IL18 IL1B IL2 IL6
36 10.83 IL18 IL1B IL2 IL6
37 10.79 IL1B IL2 IL6
38 10.78 IL18 IL1B IL2 IL6
39 10.38 IL18 IL1B

GO Terms for Uremic Pruritus

Cellular components related to Uremic Pruritus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CRP IL18 IL1B IL2 IL31 IL6
2 extracellular space GO:0005615 9.1 CRP IL18 IL1B IL2 IL31 IL6

Biological processes related to Uremic Pruritus according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.88 CRP IL18 IL1B IL6
2 inflammatory response GO:0006954 9.85 CRP IL18 IL1B IL6
3 cell-cell signaling GO:0007267 9.82 IL18 IL1B IL2
4 MAPK cascade GO:0000165 9.81 IL18 IL1B IL2
5 cellular response to lipopolysaccharide GO:0071222 9.78 IL1B IL6 OPRK1
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 IL18 IL1B IL6
7 immune response GO:0006955 9.77 IL18 IL1B IL2 IL6 OPRK1
8 regulation of signaling receptor activity GO:0010469 9.72 IL18 IL1B IL2 IL31 IL6
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 IL18 IL2 IL6
10 response to cocaine GO:0042220 9.65 CNR1 OPRK1
11 acute-phase response GO:0006953 9.65 CRP IL6
12 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 IL18 IL1B
13 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.64 IL1B IL2
14 positive regulation of p38MAPK cascade GO:1900745 9.63 IL1B OPRK1
15 natural killer cell activation GO:0030101 9.62 IL18 IL2
16 positive regulation of activated T cell proliferation GO:0042104 9.62 IL18 IL2
17 negative regulation of neurogenesis GO:0050768 9.61 IL1B IL6
18 positive regulation of T cell proliferation GO:0042102 9.61 IL1B IL2 IL6
19 positive regulation of glial cell proliferation GO:0060252 9.6 IL1B IL6
20 positive regulation of interleukin-17 production GO:0032740 9.58 IL18 IL2
21 positive regulation of interferon-gamma production GO:0032729 9.58 IL18 IL1B IL2
22 positive regulation of immunoglobulin secretion GO:0051024 9.57 IL2 IL6
23 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.56 IL18 IL1B
24 negative regulation of lipid storage GO:0010888 9.54 CRP IL6
25 interleukin-6 production GO:0032635 9.52 IL18 IL1B
26 positive regulation of tissue remodeling GO:0034105 9.51 IL18 IL2
27 positive regulation of fever generation GO:0031622 9.48 CNR1 IL1B
28 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.46 IL18 IL1B
29 cytokine-mediated signaling pathway GO:0019221 9.35 IL18 IL1B IL2 IL31 IL6
30 response to ethanol GO:0045471 9.33 CNR1 IL2 OPRK1
31 response to morphine GO:0043278 9.26 CNR1 OPRK1
32 positive regulation of neuroinflammatory response GO:0150078 8.8 IL18 IL1B IL6

Molecular functions related to Uremic Pruritus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IL18 IL1B IL2 IL31 IL6

Sources for Uremic Pruritus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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