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MCID: URT021
MIFTS: 20

Ureter Squamous Cell Carcinoma

Categories: Cancer diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Ureter Squamous Cell Carcinoma

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MalaCards integrated aliases for Ureter Squamous Cell Carcinoma:

Name: Ureter Squamous Cell Carcinoma 12 15 71
Ureteral Epidermoid Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5539
NCIt 49 C6154
UMLS 71 C1336879
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Summaries for Ureter Squamous Cell Carcinoma

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Disease Ontology : 12 A squamous cell carcinoma that is located in the ureter.

MalaCards based summary : Ureter Squamous Cell Carcinoma, also known as ureteral epidermoid carcinoma, is related to squamous cell carcinoma and hydronephrosis, and has symptoms including flank pain An important gene associated with Ureter Squamous Cell Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include ureter, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Ureter Squamous Cell Carcinoma

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Diseases related to Ureter Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.2
2 hydronephrosis 10.0
3 ureter inverted papilloma 10.0
4 inverted transitional papilloma 9.9 KRT7 KRT5
5 papilloma 9.9 KRT7 KRT5
6 ureter adenocarcinoma 9.9 KRT7 KRT5
7 ceruminoma 9.9 KRT7 KRT5
8 malignant acrospiroma 9.9 KRT7 KRT5
9 microinvasive cervical squamous cell carcinoma 9.9 KRT7 KRT5
10 subareolar duct papillomatosis 9.9 KRT7 KRT5
11 cutaneous mucoepidermoid carcinoma 9.9 KRT7 KRT5
12 mucoepidermoid carcinoma 9.9 KRT7 KRT5
13 nipple benign neoplasm 9.9 KRT7 KRT5
14 benign breast adenomyoepithelioma 9.9 KRT7 KRT5
15 auditory system benign neoplasm 9.9 KRT7 KRT5
16 ceruminous adenocarcinoma 9.9 KRT7 KRT5
17 eccrine adenocarcinoma 9.9 KRT7 KRT5
18 external ear carcinoma 9.8 KRT7 KRT5
19 vulvar apocrine adenocarcinoma 9.8 KRT7 KRT5
20 apocrine adenocarcinoma 9.8 KRT7 KRT5
21 middle ear adenoma 9.8 KRT7 KRT5
22 lung clear cell carcinoma 9.8 KRT7 KRT5
23 gastric squamous cell carcinoma 9.8 KRT7 KRT5
24 necrotizing sialometaplasia 9.8 KRT7 KRT5
25 sensory organ benign neoplasm 9.8 KRT7 KRT5
26 squamous cell bile duct carcinoma 9.8 KRT7 KRT5
27 bile duct mucoepidermoid carcinoma 9.8 KRT7 KRT5
28 breast mucinous carcinoma 9.8 KRT7 KRT5
29 clear cell hidradenoma 9.8 KRT7 KRT5
30 hidradenoma 9.8 KRT7 KRT5
31 middle ear adenocarcinoma 9.8 KRT7 KRT5
32 malignant biphasic mesothelioma 9.8 KRT7 KRT5
33 benign mesothelioma 9.8 KRT7 KRT5
34 pericardium cancer 9.8 KRT7 KRT5
35 eccrine sweat gland cancer 9.8 KRT7 KRT5
36 sweat gland cancer 9.8 KRT7 KRT5
37 papillary squamous carcinoma 9.8 KRT7 KRT5
38 large cell acanthoma 9.8 KRT7 KRT5
39 balloon cell malignant melanoma 9.8 KRT7 KRT5
40 nephrogenic adenoma of the urethra 9.8 KRT7 KRT5
41 cystadenofibroma 9.8 KRT7 KRT5
42 eccrine acrospiroma 9.8 KRT7 KRT5
43 liver leiomyosarcoma 9.8 KRT7 KRT5
44 eccrine sweat gland neoplasm 9.8 KRT7 KRT5
45 solid adenocarcinoma with mucin production 9.8 KRT7 KRT5
46 thymus clear cell carcinoma 9.8 KRT7 KRT5
47 eccrine porocarcinoma 9.8 KRT7 KRT5
48 eccrine papillary adenocarcinoma 9.8 KRT7 KRT5
49 cutaneous adenocystic carcinoma 9.8 KRT7 KRT5
50 nasal cavity olfactory neuroblastoma 9.8 KRT7 KRT5

Graphical network of the top 20 diseases related to Ureter Squamous Cell Carcinoma:



Diseases related to Ureter Squamous Cell Carcinoma
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Symptoms & Phenotypes for Ureter Squamous Cell Carcinoma

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UMLS symptoms related to Ureter Squamous Cell Carcinoma:


flank pain

GenomeRNAi Phenotypes related to Ureter Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.23 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.23 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.23 KRT5 KRT7
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Drugs & Therapeutics for Ureter Squamous Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Ureter Squamous Cell Carcinoma

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Genetic Tests for Ureter Squamous Cell Carcinoma

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Anatomical Context for Ureter Squamous Cell Carcinoma

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The Foundational Model of Anatomy Ontology organs/tissues related to Ureter Squamous Cell Carcinoma:

19
Ureter
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Publications for Ureter Squamous Cell Carcinoma

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Articles related to Ureter Squamous Cell Carcinoma:

# Title Authors PMID Year
1
Primary renal pelvis and ureter squamous cell carcinoma (SCC): a rare case report and review of literature. 61
31303798 2019
2
[Primary squamous cell carcinoma of the ureter: a case report]. 61
7645455 1995
3
An inherited form of large bowel cancer: Muir's syndrome. 61
7357506 1980
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Variations for Ureter Squamous Cell Carcinoma

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Expression for Ureter Squamous Cell Carcinoma

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Search GEO for disease gene expression data for Ureter Squamous Cell Carcinoma.
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Pathways for Ureter Squamous Cell Carcinoma

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Pathways related to Ureter Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
11.64 KRT7 KRT5
2
Keratinization 65
Show member pathways
 11.41 KRT7 KRT5
3
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 10.66 KRT7 KRT5
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GO Terms for Ureter Squamous Cell Carcinoma

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Cellular components related to Ureter Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.96 KRT7 KRT5
2 keratin filament GO:0045095 8.62 KRT7 KRT5

Biological processes related to Ureter Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 8.96 KRT7 KRT5
2 cornification GO:0070268 8.62 KRT7 KRT5
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Sources for Ureter Squamous Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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