MCID: URT031
MIFTS: 42

Ureteral Disease

Categories: Nephrological diseases

Aliases & Classifications for Ureteral Disease

MalaCards integrated aliases for Ureteral Disease:

Name: Ureteral Disease 12 15
Ureteral Diseases 43 71
Ureteral Disorders 42
Disorder of Ureter 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1426
MeSH 43 D014515
NCIt 49 C27148
UMLS 71 C0041954 C0403608

Summaries for Ureteral Disease

MedlinePlus : 42 Your kidneys make urine by filtering wastes and extra water from your blood. The urine travels from the kidneys to the bladder in two thin tubes called ureters. The ureters are about 8 to 10 inches long. Muscles in the ureter walls tighten and relax to force urine down and away from the kidneys. Small amounts of urine flow from the ureters into the bladder about every 10 to 15 seconds. Sometimes the ureters can become blocked or injured. This can block the flow of urine to the bladder. If urine stands still or backs up the ureter, you may get a urinary tract infections. Doctors diagnose problems with the ureters using different tests. These include urine tests, x-rays, and examination of the ureter with a scope called a cystoscope. Treatment depends on the cause of the problem. It may include medicines and, in severe cases, surgery. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Ureteral Disease, also known as ureteral diseases, is related to ureterocele and vesicoureteral reflux 1. An important gene associated with Ureteral Disease is SLC3A1 (Solute Carrier Family 3 Member 1), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Tamsulosin and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include ureter, kidney and testes, and related phenotypes are cardiovascular system and growth/size/body region

Disease Ontology : 12 A urinary system disease that is located in the ureter.

Wikipedia : 74 The ureters are tubes made of smooth muscle fibers that propel urine from the kidneys to the urinary... more...

Related Diseases for Ureteral Disease

Diseases related to Ureteral Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 ureterocele 32.8 PAX2 MCU
2 vesicoureteral reflux 1 32.2 UPK3A TGFB1 REN PAX2 MCU
3 glomerulonephritis 30.1 TGFB1 SMAD2 FN1 CCN2 CCL2
4 hydronephrosis 29.9 UPK3A TGFB1 REN PAX2 MCU CCL2
5 myasthenic syndrome, congenital, 22 10.6 SLC3A1 PREPL
6 keloid disorder 10.6 TGFB1 SMAD3
7 multicystic dysplastic kidney 10.6 REN PAX2
8 hypertrophic scars 10.6 TGFB1 SMAD3 SMAD2
9 compensatory emphysema 10.6 CCN2 BMP7
10 urethra cancer 10.5 UPK3A PAX2
11 pauci-immune glomerulonephritis 10.5 SMAD2 CCN2 BMP7
12 microvascular complications of diabetes 3 10.5 TGFB1 REN CCN2
13 clear cell adenocarcinoma 10.5 SMAD3 SMAD2 PAX2
14 congenital anomalies of kidney and urinary tract 2 10.5 UPK3A REN PAX2
15 amino acid metabolic disorder 10.5 SLC7A9 SLC3A1 SLC1A7
16 posterior urethral valves 10.5 TGFB1 SLC3A1
17 urethral stricture 10.5 TGFB1 MCU CCN2
18 diffuse pulmonary fibrosis 10.5 FN1 BMP7
19 kidney hypertrophy 10.5 TGFB1 REN FN1 CCN2
20 hypotonia-cystinuria syndrome 10.5 SLC7A9 SLC3A1 SLC1A7 PREPL
21 cystinuria 10.5 SLC7A9 SLC3A1 SLC1A7 PREPL
22 autosomal dominant non-syndromic intellectual disability 19 10.5 SMAD3 SMAD2
23 pustulosis palmaris et plantaris 10.5 TGFB1 SMAD7 CCR6
24 pyelitis 10.5 UPK3A REN CCR6
25 vitreous disease 10.5 SMAD2 FN1 CCN2 CCL2
26 gingival fibromatosis 10.5 TGFB1 FN1 CCN2
27 carpal tunnel syndrome 10.5 TGFB1 CCN2 CCL2
28 localized scleroderma 10.5 TGFB1 SMAD7 SMAD3 CCN2
29 urethral diverticulum 10.5 UPK3A MCU
30 collagen disease 10.5 SMAD3 FN1 CCR6 CCN2
31 crescentic glomerulonephritis 10.4 SERPINE1 CCN2 CCL2
32 vitreoretinopathy, neovascular inflammatory 10.4 TGFB1 FN1 CCN2 CCL2
33 hepatic vascular disease 10.4 SERPINE1 REN CCR6
34 retinal vascular disease 10.4 REN FN1 CCN2 CCL2
35 extrinsic cardiomyopathy 10.4 REN CCR6 CCL2
36 peyronie's disease 10.4 TGFB1 SMAD7 SMAD3 CCL2
37 paranasal sinus disease 10.4 TGFB1 SERPINE1 CCR6
38 extrinsic allergic alveolitis 10.4 FN1 CCR6 CCL2
39 cakut 10.4 UPK3A REN PAX2
40 ureteral obstruction 10.4 TGFB1 BMP7 AQP2
41 nephrosclerosis 10.4 TGFB1 CCN2 CCL2 BMP7
42 inherited metabolic disorder 10.4 SLC3A1 REN CCR6 CCL2
43 nephrogenic systemic fibrosis 10.4 TGFB1 SMAD7 SMAD3 SMAD2 CCN2
44 obstructive nephropathy 10.4 TGFB1 SMAD3 SMAD2 REN CCL2
45 portal hypertension 10.4 TGFB1 SERPINE1 CCN2
46 loeys-dietz syndrome 10.4 SMAD3 SMAD2 CCN2
47 nephrolithiasis, calcium oxalate 10.4 SLC7A9 SLC3A1 REN CCL2 AQP2
48 stiff skin syndrome 10.4 TGFB1 CCN2
49 pneumoconiosis 10.3 TGFB1 SERPINE1 FN1 CCN2 CCL2
50 overnutrition 10.3 SERPINE1 REN CCR6 CCL2

Graphical network of the top 20 diseases related to Ureteral Disease:



Diseases related to Ureteral Disease

Symptoms & Phenotypes for Ureteral Disease

MGI Mouse Phenotypes related to Ureteral Disease:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.31 BMP7 CCN2 CCR6 CDH1 FN1 MCU
2 growth/size/body region MP:0005378 10.28 AQP2 BMP7 CCN2 CDH1 FN1 MCU
3 homeostasis/metabolism MP:0005376 10.24 AQP2 CCN2 CCR6 CDH1 FN1 MCU
4 hematopoietic system MP:0005397 10.14 AQP2 BMP7 CCR6 FN1 REN SERPINE1
5 immune system MP:0005387 10.13 BMP7 CCL2 CCR6 CDH1 FN1 REN
6 embryo MP:0005380 10.11 BMP7 CCN2 CDH1 FN1 PAX2 SMAD2
7 craniofacial MP:0005382 10.02 BMP7 CCN2 FN1 SMAD2 SMAD3 SMAD7
8 mortality/aging MP:0010768 10 AQP2 BMP7 CCN2 CDH1 FN1 MCU
9 integument MP:0010771 9.96 AQP2 BMP7 CCN2 CDH1 FN1 SERPINE1
10 renal/urinary system MP:0005367 9.65 AQP2 BMP7 PAX2 REN SERPINE1 SLC3A1
11 reproductive system MP:0005389 9.32 AQP2 BMP7 CDH1 FN1 PAX2 REN

Drugs & Therapeutics for Ureteral Disease

Drugs for Ureteral Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
2 Neurotransmitter Agents Phase 4
3 Adrenergic alpha-Antagonists Phase 4
4 Adrenergic Antagonists Phase 4
5 Adrenergic Agents Phase 4
6
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
7 Anesthetics, Local Phase 2
8 Anti-Arrhythmia Agents Phase 2
9 Anesthetics Phase 2
10 Sodium Channel Blockers Phase 2
11 Central Nervous System Depressants Phase 2
12 Diuretics, Potassium Sparing Phase 2
13
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
14
Gemcitabine Approved Phase 1 95058-81-4 60750
15 Immunologic Factors Phase 1
16 Anti-Infective Agents Phase 1
17 Antiviral Agents Phase 1
18 Antimetabolites Phase 1
19 Immunosuppressive Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Daily Versus Twice Per Day Tamsulosin on Ureteral Stent Symptoms Following Ureteroscopy for Nephrolithiasis Enrolling by invitation NCT03799120 Phase 4 Tamsulosin BID
2 A Randomized Control Trial Comparing Single to Multiple Application Lidocaine Analgesia Prior to Urethral Catheterization Procedures Completed NCT00142064 Phase 2
3 A Phase I/1b Study of Enzalutamide in Combination With Gemcitabine and Cisplatin in Bladder Cancer Completed NCT02300610 Phase 1 Enzalutamide;Cisplatin;Gemcitabine

Search NIH Clinical Center for Ureteral Disease

Cochrane evidence based reviews: ureteral diseases

Genetic Tests for Ureteral Disease

Anatomical Context for Ureteral Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Ureteral Disease:

19
Ureter

MalaCards organs/tissues related to Ureteral Disease:

40
Kidney, Testes, Smooth Muscle, Liver, Prostate, Cervix, Skin

Publications for Ureteral Disease

Articles related to Ureteral Disease:

(show top 50) (show all 75)
# Title Authors PMID Year
1
Kidney and Ureteral Stones. 42
31563199 2019
2
Pediatric urolithiasis. 42
31630712 2019
3
Permanent Implantable Medical Devices in Exotic Pet Medicine. 42
31395329 2019
4
Does Early Ureteroneocystostomy After Iatrogenic Ureteral Injury Jeopardize Outcome? 61
31751624 2020
5
Highly Stable and Bright NIR-II AIE Dots for Intraoperative Identification of Ureter. 61
31970976 2020
6
Robot-assisted laparoscopic ureteroneocystostomy in adults: A single surgeon experience and literature review. 61
31970070 2020
7
Interventional Radiology and Interventional Endoscopy in Treatment of Nephroureteral Disease in the Dog and Cat. 61
29909932 2018
8
In vitro, in vivo, and clinical tests of a novel flexible ureteroscope for the diagnosis and treatment of kidney and ureteral diseases. 61
30182078 2018
9
Therapeutic strategies for upper tract urothelial carcinoma. 61
29848133 2018
10
Feline ureteral obstructions Part 2: surgical management. 61
29781101 2018
11
Numerical analysis of urine flow through the side holes of a double J stent in a ureteral stenosis. 61
28582893 2017
12
Long-Term Outcomes of Laparoscopic Nephroureterectomy with Transurethral Circumferential Excision of the Ureteral Orifice for Urothelial Carcinoma. 61
28385045 2017
13
Analysis of Urine Flow in Three Different Ureter Models. 61
28659992 2017
14
The effect of tumor location on oncologic outcomes in patients with upper urinary tract urothelial carcinoma stratified by pathologic stage. 61
26351152 2016
15
Deep infiltrating endometriosis affecting the urinary tract-surgical treatment and fertility outcomes in 2004-2013. 61
28003801 2016
16
Renal Autotransplantation: 27-Year Experience at 2 Institutions. 61
26055825 2015
17
MULTIDETECTOR-ROW COMPUTED TOMOGRAPHIC CHARACTERISTICS OF PRESUMED PREURETERAL VENA CAVA IN CATS. 61
25786990 2015
18
Oncologic outcomes and prognostic impact of urothelial recurrences in patients undergoing segmental and total ureterectomy for upper tract urothelial carcinoma. 61
26085878 2015
19
Robotic-assisted laparoscopic surgery: recent advances in urology. 61
24993800 2014
20
Effects of furosemide on ureteral diameter and attenuation using computed tomographic excretory urography in normal dogs. 61
22963173 2013
21
Role of routine transurethral biopsy and isolated upper tract cytology after intravesical treatment of high-grade non-muscle invasive bladder cancer. 61
22762480 2012
22
Practical value of intravenous urography combined with add-on CT in diagnosing ureteral abnormalities. 61
22613603 2012
23
Bilateral hydronephrosis secondary to endometriosis managed by endoscopic ureteral stent placement in a captive Guinea baboon (Papio papio). 61
22204076 2011
24
Incidence and survival of patients with carcinoma of the ureter and renal pelvis in the USA, 1973-2005. 61
20825397 2011
25
Wegener's granulomatosis: a rare cause of hydronephrosis. 61
21577265 2011
26
Laparoscopic conservative management of ureteral endometriosis. 61
20610998 2010
27
Laparoscopic management of ureteral endometriosis: the Stanford University hospital experience with 96 consecutive cases. 61
19837436 2009
28
Techniques for laparoscopic and robotic localization of intraluminal ureteral pathology. 61
19147208 2009
29
Arteriovenous fistula in an autotransplanted kidney segment: successful angiographic management. 61
19921990 2009
30
[Bilateral multiple ureteral polyps causing intermittent hydronephrosis: a case report]. 61
18260348 2008
31
Reno-ureteral diseases inducing hypertension in children. 61
19480305 2008
32
Ureteral intussusception due to a polyp. 61
17151895 2007
33
[Holmium: YAG laser lithotripsy under ureteroscopy for treating urinary caluli combined with acute renal failure]. 61
16568567 2006
34
[Radical operative treatment (nephrectomy and nephroureterectomy) in urology. Aspects and opinions]. 61
16042068 2004
35
Evaluation of the ureter and ureterovesicular junction using helical computed tomographic excretory urography in healthy dogs. 61
12718349 2003
36
Endometriosis of the urinary tract. 61
12476526 2002
37
[Spiral CT urography and CT virtual endoscopy in detecting urological diseases]. 61
12133345 2002
38
[Technical solution for single kidney patients with multiple ureteral neoplasms]. 61
11822068 2001
39
In vitro contractile effects of neurokinin receptor blockade in the human ureter. 61
11547127 2001
40
A new generation of semirigid fiberoptic ureteroscopes. 61
10102126 1999
41
Upper ureteral reconstructive surgery. 61
10086059 1999
42
Demonstration of a "renogastric reflex" after rapid distension of renal pelvis and ureter in nonanesthetized patients. 61
9886585 1999
43
A study of the effect of renal pelvic and ureteric distention on the anorectal function with identification of the "reno-anal reflex". 61
9563975 1998
44
Ipsilateral ureteroureterostomy for single ureteral reflux or obstruction in a duplicate system. 61
9474221 1998
45
Subcutaneous ureteral replacement: a canine model. 61
9659639 1998
46
Use of small and large bowel in renal transplantation. 61
9391535 1997
47
[Long-term follow up of patients surgically treated for pyelo-ureteral disease by the Anderson-Hynes technique]. 61
9181916 1997
48
[Damage to the lumbosacral plexus in psoas hitch operation]. 61
8851298 1996
49
Transurethral ureteroscopic ureterotomy assisted by a prior balloon dilation for relieving ureteral strictures. 61
7714955 1995
50
Extensive dilation of distal ureter for endoscopic treatment of large volume ureteral disease. 61
7869503 1995

Variations for Ureteral Disease

Expression for Ureteral Disease

Search GEO for disease gene expression data for Ureteral Disease.

Pathways for Ureteral Disease

Pathways related to Ureteral Disease according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 TGFB1 SMAD3 SMAD2 FN1 CDH1 CCR6
2
Show member pathways
13.47 TGFB1 SMAD7 SMAD3 SMAD2 CDH1 CCN2
3
Show member pathways
13.22 TGFB1 SMAD3 CDH1 CCR6 CCN2 CCL2
4 12.77 TGFB1 SMAD3 SMAD2 FN1 CDH1
5
Show member pathways
12.67 TGFB1 SERPINE1 FN1 CDH1 BMP7
6
Show member pathways
12.4 TGFB1 SMAD3 SMAD2 BMP7
7 12.28 TGFB1 SMAD3 SMAD2 CDH1
8
Show member pathways
12.26 TGFB1 SMAD7 SMAD3 SMAD2 SERPINE1
9 12.13 TGFB1 SMAD3 SMAD2 SERPINE1 MCU
10 12.12 TGFB1 SMAD3 SMAD2 CDH1
11 12.04 SMAD3 SMAD2 SERPINE1 CDH1 CCN2
12 12.02 TGFB1 SMAD7 SMAD3 SMAD2 FN1
13 11.96 TGFB1 SMAD3 SMAD2 SERPINE1 PAX2 CCN2
14 11.9 TGFB1 SMAD3 SERPINE1 FN1
15 11.85 TGFB1 SMAD7 SMAD3 SMAD2
16 11.85 TGFB1 SMAD7 SMAD3 SMAD2 BMP7
17
Show member pathways
11.8 TGFB1 SMAD3 SMAD2
18 11.77 TGFB1 REN CCL2
19 11.74 SMAD7 SMAD3 SMAD2 SERPINE1
20 11.73 TGFB1 SMAD3 SMAD2 SERPINE1 FN1 CCL2
21
Show member pathways
11.69 TGFB1 SMAD3 SMAD2
22 11.69 TGFB1 SMAD7 SMAD3 SMAD2 SERPINE1
23
Show member pathways
11.68 TGFB1 SMAD7 SMAD3 SMAD2
24 11.64 TGFB1 SMAD3 SMAD2 BMP7
25 11.6 TGFB1 SMAD7 CCN2 CCL2 BMP7
26 11.53 TGFB1 SMAD7 SMAD3 SMAD2 SERPINE1
27 11.43 TGFB1 SMAD7 SMAD3 SMAD2 CCN2
28 11.41 TGFB1 SMAD7 SMAD3 SMAD2 SERPINE1 CDH1
29 11.24 TGFB1 SMAD3 SMAD2
30 11.16 SMAD3 SMAD2 SERPINE1 CCN2
31 10.97 TGFB1 FN1 CDH1 CCN2 CCL2 BMP7
32 10.61 TGFB1 SMAD3 SMAD2 FN1 CDH1

GO Terms for Ureteral Disease

Cellular components related to Ureteral Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.97 UPK3A TGFB1 SMAD7 SMAD3 SLC7A9 SLC3A1
2 platelet alpha granule lumen GO:0031093 9.5 TGFB1 SERPINE1 FN1
3 collagen-containing extracellular matrix GO:0062023 9.35 TGFB1 SERPINE1 FN1 CCN2 BMP7
4 SMAD protein complex GO:0071141 9.26 SMAD3 SMAD2
5 heteromeric SMAD protein complex GO:0071144 8.62 SMAD3 SMAD2

Biological processes related to Ureteral Disease according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.19 TGFB1 SMAD7 SMAD3 SMAD2 SERPINE1 PAX2
2 positive regulation of transcription, DNA-templated GO:0045893 10.08 TGFB1 SMAD3 SMAD2 PAX2 CDH1 BMP7
3 angiogenesis GO:0001525 9.98 SERPINE1 FN1 CCN2 CCL2
4 positive regulation of gene expression GO:0010628 9.97 TGFB1 SMAD3 SMAD2 FN1 CCN2 BMP7
5 response to organic substance GO:0010033 9.87 TGFB1 REN CDH1
6 BMP signaling pathway GO:0030509 9.86 TGFB1 SMAD7 BMP7
7 response to wounding GO:0009611 9.85 TGFB1 FN1 CCN2
8 response to glucose GO:0009749 9.84 TGFB1 SMAD2 CCN2
9 transforming growth factor beta receptor signaling pathway GO:0007179 9.84 TGFB1 SMAD7 SMAD3 SMAD2
10 cellular response to transforming growth factor beta stimulus GO:0071560 9.81 TGFB1 SMAD7 SMAD3
11 regulation of MAPK cascade GO:0043408 9.81 TGFB1 REN BMP7
12 wound healing GO:0042060 9.78 TGFB1 SMAD3 SMAD2 FN1
13 protein kinase B signaling GO:0043491 9.76 TGFB1 PAX2 CCL2
14 positive regulation of protein import into nucleus GO:0042307 9.75 TGFB1 SMAD3 CDH1
15 positive regulation of bone mineralization GO:0030501 9.74 TGFB1 SMAD3 BMP7
16 mesoderm formation GO:0001707 9.73 SMAD3 SMAD2 BMP7
17 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.73 TGFB1 SMAD7 SMAD3 SMAD2
18 endoderm development GO:0007492 9.72 TGFB1 SMAD3 SMAD2
19 negative regulation of wound healing GO:0061045 9.7 SMAD3 SERPINE1
20 negative regulation of cell-cell adhesion GO:0022408 9.7 TGFB1 CDH1
21 pathway-restricted SMAD protein phosphorylation GO:0060389 9.69 TGFB1 SMAD7
22 lens fiber cell differentiation GO:0070306 9.68 TGFB1 SMAD3
23 response to cholesterol GO:0070723 9.68 TGFB1 SMAD2
24 nodal signaling pathway GO:0038092 9.67 SMAD3 SMAD2
25 salivary gland morphogenesis GO:0007435 9.67 TGFB1 BMP7
26 SMAD protein signal transduction GO:0060395 9.67 TGFB1 SMAD3 SMAD2 BMP7
27 pericardium development GO:0060039 9.66 SMAD3 SMAD2
28 embryonic foregut morphogenesis GO:0048617 9.66 SMAD3 SMAD2
29 primary miRNA processing GO:0031053 9.65 SMAD3 SMAD2
30 metanephric collecting duct development GO:0072205 9.65 PAX2 AQP2
31 response to laminar fluid shear stress GO:0034616 9.65 TGFB1 SMAD7
32 common-partner SMAD protein phosphorylation GO:0007182 9.63 TGFB1 SMAD2
33 embryonic pattern specification GO:0009880 9.63 SMAD3 SMAD2 BMP7
34 positive regulation of extracellular matrix assembly GO:1901203 9.62 TGFB1 SMAD3
35 connective tissue development GO:0061448 9.62 TGFB1 CCN2
36 positive regulation of epithelial to mesenchymal transition GO:0010718 9.62 TGFB1 SMAD3 SMAD2 BMP7
37 regulation of striated muscle tissue development GO:0016202 9.61 TGFB1 SMAD3
38 negative regulation of cytolysis GO:0045918 9.6 TGFB1 PAX2
39 L-cystine transport GO:0015811 9.59 SLC7A9 SLC3A1
40 mesonephros development GO:0001823 9.58 REN PAX2 BMP7
41 paraxial mesoderm morphogenesis GO:0048340 9.52 SMAD3 SMAD2
42 evasion or tolerance of host defenses by virus GO:0019049 9.51 TGFB1 SMAD3
43 SMAD protein complex assembly GO:0007183 9.43 TGFB1 SMAD3 SMAD2
44 regulation of binding GO:0051098 9.33 TGFB1 SMAD3 SMAD2
45 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.26 TGFB1 SMAD7 SMAD3 SMAD2
46 ureteric bud development GO:0001657 9.02 TGFB1 SMAD7 SMAD3 SMAD2 BMP7

Molecular functions related to Ureteral Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.28 UPK3A TGFB1 SMAD7 SMAD3 SMAD2 SLC7A9
2 beta-catenin binding GO:0008013 9.63 SMAD7 SMAD3 CDH1
3 collagen binding GO:0005518 9.58 SMAD7 SMAD3 FN1
4 enhancer binding GO:0035326 9.49 SMAD3 SMAD2
5 co-SMAD binding GO:0070410 9.48 SMAD3 SMAD2
6 I-SMAD binding GO:0070411 9.43 SMAD7 SMAD2
7 primary miRNA binding GO:0070878 9.37 SMAD3 SMAD2
8 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.26 SMAD3 SMAD2
9 L-cystine transmembrane transporter activity GO:0015184 9.16 SLC7A9 SLC3A1
10 type I transforming growth factor beta receptor binding GO:0034713 9.13 TGFB1 SMAD7 SMAD2
11 transforming growth factor beta receptor binding GO:0005160 8.92 TGFB1 SMAD3 SMAD2 BMP7

Sources for Ureteral Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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