MCID: URT023
MIFTS: 26

Ureteric Orifice Cancer

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Ureteric Orifice Cancer

MalaCards integrated aliases for Ureteric Orifice Cancer:

Name: Ureteric Orifice Cancer 12 15
Malignant Neoplasm of Ureteric Orifice of Urinary Bladder 12
Malignant Tumor of Ureteric Orifice 12
Orifice of the Ureter 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11818
ICD9CM 34 188.6
NCIt 49 C12337
SNOMED-CT 67 188245008
ICD10 32 C67.6
UMLS 71 C0153614

Summaries for Ureteric Orifice Cancer

MalaCards based summary : Ureteric Orifice Cancer, also known as malignant neoplasm of ureteric orifice of urinary bladder, is related to autosomal recessive cutis laxa type iii and cutis laxa, autosomal recessive, type ib. An important gene associated with Ureteric Orifice Cancer is EFEMP2 (EGF Containing Fibulin Extracellular Matrix Protein 2), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. Affiliated tissues include kidney, and related phenotypes are cardiovascular system and integument

Related Diseases for Ureteric Orifice Cancer

Diseases related to Ureteric Orifice Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 autosomal recessive cutis laxa type iii 10.3 FBLN5 EFEMP2
2 cutis laxa, autosomal recessive, type ib 10.2 FBLN5 EFEMP2
3 cutis laxa, autosomal recessive, type iia 10.2 FBLN5 EFEMP2
4 cutis laxa, autosomal recessive, type ic 10.2 FBLN5 EFEMP2
5 cutis laxa, autosomal recessive, type iib 10.2 FBLN5 EFEMP2
6 geroderma osteodysplasticum 10.2 FBLN5 EFEMP2
7 doyne honeycomb retinal dystrophy 10.2 FBLN5 EFEMP2
8 loeys-dietz syndrome 3 10.1 FBN1 EFEMP2
9 hypermobile ehlers-danlos syndrome 10.1 TNXB FBN1
10 hypermobility syndrome 10.1 TNXB FBN1
11 pyuria 10.0
12 rubella 10.0
13 decubitus ulcer 10.0 SLC7A1 NGF
14 chronic ulcer of skin 9.9 SLC7A1 NGF
15 tricuspid valve prolapse 9.9 FBN1 FBLN5 EFEMP2
16 cutis laxa, autosomal recessive, type ia 9.9 FBN1 FBLN5 EFEMP2
17 acquired cutis laxa 9.9 FBLN5 ELN
18 fbln5-related cutis laxa 9.9 FBLN5 ELN
19 heritable thoracic aortic disease 9.9 LOX FBN1
20 late-onset focal dermal elastosis 9.8 FBN1 ELN
21 pseudoxanthoma elasticum-like papillary dermal elastolysis 9.8 FBN1 ELN
22 chronic actinic dermatitis 9.8 FBN1 ELN
23 familial abdominal aortic aneurysm 9.8 FBN1 ELN
24 iris disease 9.6 FBN1 ELN
25 mitral valve insufficiency 9.6 FBN1 ELN
26 sorsby fundus dystrophy 9.6 FBN1 ELN
27 aortic valve insufficiency 9.6 FBN1 ELN EFEMP2
28 mid-dermal elastolysis 9.5 FBN1 FBLN5 ELN
29 collagen disease 9.5 TNXB FBN1 ELN
30 telangiectasis 9.5 FBN1 ELN
31 aortic aneurysm, familial abdominal, 1 9.5 TNXB FBN1 ELN
32 bladder diverticulum 9.5 LOX ELN EFEMP2
33 pneumothorax 9.5 FBN1 FBLN5 ELN
34 oral submucous fibrosis 9.5 LOX ELN
35 weill-marchesani syndrome 9.5 FBN1 ELN
36 ehlers-danlos syndrome 9.5 TNXB FBN1 ELN
37 mitral valve disease 9.4 FBN1 ELN
38 aneurysm 9.4 LOX FBN1 ELN
39 aortic dissection 9.3 LOX FBN1 ELN
40 autosomal recessive cutis laxa type i 9.3 FBN1 FBLN5 ELN EFEMP2
41 autosomal recessive cutis laxa type ii classic type 9.3 FBN1 FBLN5 ELN EFEMP2
42 exfoliation syndrome 9.3 LOX FBN1 ELN
43 arterial tortuosity syndrome 9.3 FBN1 FBLN5 ELN EFEMP2
44 familial thoracic aortic aneurysm and aortic dissection 9.3 LOX FBN1 ELN
45 supravalvular aortic stenosis 9.3 FBN1 FBLN5 ELN EFEMP2
46 cutis laxa, autosomal dominant 1 9.3 FBN1 FBLN5 ELN EFEMP2
47 loeys-dietz syndrome 9.3 FBN1 FBLN5 ELN EFEMP2
48 aortic disease 9.3 LOX FBN1 ELN
49 marfan syndrome 9.3 LOX FBN1 ELN
50 orthostatic intolerance 9.2 TNXB SLC7A1 FBN1 ELN

Graphical network of the top 20 diseases related to Ureteric Orifice Cancer:



Diseases related to Ureteric Orifice Cancer

Symptoms & Phenotypes for Ureteric Orifice Cancer

MGI Mouse Phenotypes related to Ureteric Orifice Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 EFEMP2 FBLN5 FBN1 LOX NGF TNXB
2 integument MP:0010771 9.43 EFEMP2 FBLN5 FBN1 LOX NGF TNXB
3 muscle MP:0005369 9.02 EFEMP2 FBLN5 FBN1 LOX NGF

Drugs & Therapeutics for Ureteric Orifice Cancer

Search Clinical Trials , NIH Clinical Center for Ureteric Orifice Cancer

Genetic Tests for Ureteric Orifice Cancer

Anatomical Context for Ureteric Orifice Cancer

MalaCards organs/tissues related to Ureteric Orifice Cancer:

40
Kidney

Publications for Ureteric Orifice Cancer

Articles related to Ureteric Orifice Cancer:

# Title Authors PMID Year
1
[Urinary dribbling in girls: which investigations in 2012?]. 61
23639836 2013
2
Unilateral vesicoureteral reflux and history of contralateral vesicoureteral reflux warranting routine bilateral endoscopic correction. 61
18710733 2008
3
Performing flexible ureteroscopy through a cystoscopy introducer sheath. 61
10475372 1999
4
[Evaluation of the results of surgical treatment of ectopic cysts of the vesical orifice of the ureter in infants as based on the radiologic examination]. 61
6364062 1983
5
[Case report on ectopic orifice of the ureter into the seminal vesicle]. 61
4783645 1973
6
[Double kidney left with ectopic orifice of the ureter coming from the upper kidney pole into the urethra]. 61
5063481 1972
7
[Arterial hypertension as the cause of insufficiency of the orifice of the ureter]. 61
13859267 1962
8
[Ectopic orifice of the ureter in a little girl. Unsuccessful attempt at conservative surgery. Possible role of rubella in the malfortion]. 61
13695612 1960
9
[Incontinence of urine caused by abnormal orifice of the ureter]. 61
14357685 1954
10
[Case of extravesical orifice of the ureter]. 61
15437630 1950

Variations for Ureteric Orifice Cancer

Expression for Ureteric Orifice Cancer

Search GEO for disease gene expression data for Ureteric Orifice Cancer.

Pathways for Ureteric Orifice Cancer

Pathways related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.55 VEGFB NGF FBN1 ELN EFEMP2
2
Show member pathways
12.09 TNXB LOX FBN1 FBLN5 ELN EFEMP2
3
Show member pathways
10.88 LOX FBN1 FBLN5 ELN EFEMP2
4 10.46 VEGFB NGF FBN1 ELN EFEMP2

GO Terms for Ureteric Orifice Cancer

Cellular components related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 VEGFB TNXB NGF LOX FBN1 FBLN5
2 extracellular matrix GO:0031012 9.65 TNXB LOX FBN1 FBLN5 ELN
3 extracellular region GO:0005576 9.61 VEGFB TNXB NGF LOX FBN1 FBLN5
4 elastic fiber GO:0071953 9.32 FBLN5 ELN
5 collagen-containing extracellular matrix GO:0062023 9.1 TNXB FBN1 FBLN5 ELN EFEMP2 CLEC3B

Biological processes related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.43 VEGFB LOX FBN1
2 cellular response to transforming growth factor beta stimulus GO:0071560 9.4 FBN1 CLEC3B
3 collagen fibril organization GO:0030199 9.37 TNXB LOX
4 extracellular matrix organization GO:0030198 9.35 TNXB LOX FBN1 FBLN5 ELN
5 bone mineralization GO:0030282 9.32 LOX CLEC3B
6 cellular response to organic substance GO:0071310 9.16 LOX CLEC3B
7 elastic fiber assembly GO:0048251 8.92 TNXB LOX FBLN5 EFEMP2

Molecular functions related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.62 FBN1 FBLN5 EFEMP2 CLEC3B
2 heparin binding GO:0008201 9.46 VEGFB TNXB FBN1 CLEC3B
3 integrin binding GO:0005178 9.43 TNXB FBN1 FBLN5
4 extracellular matrix structural constituent GO:0005201 9.26 TNXB FBN1 ELN EFEMP2
5 extracellular matrix constituent conferring elasticity GO:0030023 8.8 FBN1 FBLN5 ELN

Sources for Ureteric Orifice Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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