Ureteric Orifice Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ureteric Orifice Cancer

MalaCards integrated aliases for Ureteric Orifice Cancer:

Name: Ureteric Orifice Cancer ¹² ¹⁵

Malignant Neoplasm of Ureteric Orifice of Urinary Bladder ¹²

Malignant Tumor of Ureteric Orifice ¹²

Orifice of the Ureter ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Nephrological diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Malignant neoplasms of urinary tract

Malignant neoplasm of bladder

Malignant neoplasm: Ureteric orifice

External Ids:

Disease Ontology ¹² DOID:11818

ICD9CM ³⁴ 188.6

NCIt ⁴⁹ C12337

SNOMED-CT ⁶⁷ 188245008

ICD10 ³² C67.6

UMLS ⁷¹ C0153614

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Summaries for Ureteric Orifice Cancer

MalaCards based summary : Ureteric Orifice Cancer, also known as malignant neoplasm of ureteric orifice of urinary bladder, is related to autosomal recessive cutis laxa type iii and cutis laxa, autosomal recessive, type ib. An important gene associated with Ureteric Orifice Cancer is EFEMP2 (EGF Containing Fibulin Extracellular Matrix Protein 2), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. Affiliated tissues include kidney, and related phenotypes are cardiovascular system and integument

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Related Diseases for Ureteric Orifice Cancer

Diseases related to Ureteric Orifice Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)

#	Related Disease	Score	Top Affiliating Genes
1	autosomal recessive cutis laxa type iii	10.3	FBLN5 EFEMP2
2	cutis laxa, autosomal recessive, type ib	10.2	FBLN5 EFEMP2
3	cutis laxa, autosomal recessive, type iia	10.2	FBLN5 EFEMP2
4	cutis laxa, autosomal recessive, type ic	10.2	FBLN5 EFEMP2
5	cutis laxa, autosomal recessive, type iib	10.2	FBLN5 EFEMP2
6	geroderma osteodysplasticum	10.2	FBLN5 EFEMP2
7	doyne honeycomb retinal dystrophy	10.2	FBLN5 EFEMP2
8	loeys-dietz syndrome 3	10.1	FBN1 EFEMP2
9	hypermobile ehlers-danlos syndrome	10.1	TNXB FBN1
10	hypermobility syndrome	10.1	TNXB FBN1
11	pyuria	10.0
12	rubella	10.0
13	decubitus ulcer	10.0	SLC7A1 NGF
14	chronic ulcer of skin	9.9	SLC7A1 NGF
15	tricuspid valve prolapse	9.9	FBN1 FBLN5 EFEMP2
16	cutis laxa, autosomal recessive, type ia	9.9	FBN1 FBLN5 EFEMP2
17	acquired cutis laxa	9.9	FBLN5 ELN
18	fbln5-related cutis laxa	9.9	FBLN5 ELN
19	heritable thoracic aortic disease	9.9	LOX FBN1
20	late-onset focal dermal elastosis	9.8	FBN1 ELN
21	pseudoxanthoma elasticum-like papillary dermal elastolysis	9.8	FBN1 ELN
22	chronic actinic dermatitis	9.8	FBN1 ELN
23	familial abdominal aortic aneurysm	9.8	FBN1 ELN
24	iris disease	9.6	FBN1 ELN
25	mitral valve insufficiency	9.6	FBN1 ELN
26	sorsby fundus dystrophy	9.6	FBN1 ELN
27	aortic valve insufficiency	9.6	FBN1 ELN EFEMP2
28	mid-dermal elastolysis	9.5	FBN1 FBLN5 ELN
29	collagen disease	9.5	TNXB FBN1 ELN
30	telangiectasis	9.5	FBN1 ELN
31	aortic aneurysm, familial abdominal, 1	9.5	TNXB FBN1 ELN
32	bladder diverticulum	9.5	LOX ELN EFEMP2
33	pneumothorax	9.5	FBN1 FBLN5 ELN
34	oral submucous fibrosis	9.5	LOX ELN
35	weill-marchesani syndrome	9.5	FBN1 ELN
36	ehlers-danlos syndrome	9.5	TNXB FBN1 ELN
37	mitral valve disease	9.4	FBN1 ELN
38	aneurysm	9.4	LOX FBN1 ELN
39	aortic dissection	9.3	LOX FBN1 ELN
40	autosomal recessive cutis laxa type i	9.3	FBN1 FBLN5 ELN EFEMP2
41	autosomal recessive cutis laxa type ii classic type	9.3	FBN1 FBLN5 ELN EFEMP2
42	exfoliation syndrome	9.3	LOX FBN1 ELN
43	arterial tortuosity syndrome	9.3	FBN1 FBLN5 ELN EFEMP2
44	familial thoracic aortic aneurysm and aortic dissection	9.3	LOX FBN1 ELN
45	supravalvular aortic stenosis	9.3	FBN1 FBLN5 ELN EFEMP2
46	cutis laxa, autosomal dominant 1	9.3	FBN1 FBLN5 ELN EFEMP2
47	loeys-dietz syndrome	9.3	FBN1 FBLN5 ELN EFEMP2
48	aortic disease	9.3	LOX FBN1 ELN
49	marfan syndrome	9.3	LOX FBN1 ELN
50	orthostatic intolerance	9.2	TNXB SLC7A1 FBN1 ELN

Graphical network of the top 20 diseases related to Ureteric Orifice Cancer:

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Symptoms & Phenotypes for Ureteric Orifice Cancer

MGI Mouse Phenotypes related to Ureteric Orifice Cancer:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.7	EFEMP2 FBLN5 FBN1 LOX NGF TNXB
2	integument	MP:0010771	9.43	EFEMP2 FBLN5 FBN1 LOX NGF TNXB
3	muscle	MP:0005369	9.02	EFEMP2 FBLN5 FBN1 LOX NGF

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Drugs & Therapeutics for Ureteric Orifice Cancer

Search Clinical Trials , NIH Clinical Center for Ureteric Orifice Cancer

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Genetic Tests for Ureteric Orifice Cancer

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Anatomical Context for Ureteric Orifice Cancer

MalaCards organs/tissues related to Ureteric Orifice Cancer:

⁴⁰

Kidney

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Publications for Ureteric Orifice Cancer

Articles related to Ureteric Orifice Cancer:

#	Title	Authors	PMID	Year
1	[Urinary dribbling in girls: which investigations in 2012?]. ⁶¹	Grimaldi C...Petit P	23639836	2013
2	Unilateral vesicoureteral reflux and history of contralateral vesicoureteral reflux warranting routine bilateral endoscopic correction. ⁶¹	Chertin B...Farkas A	18710733	2008
3	Performing flexible ureteroscopy through a cystoscopy introducer sheath. ⁶¹	Kim HL...Gerber GS	10475372	1999
4	[Evaluation of the results of surgical treatment of ectopic cysts of the vesical orifice of the ureter in infants as based on the radiologic examination]. ⁶¹	Kaniewska A...Grabowski K	6364062	1983
5	[Case report on ectopic orifice of the ureter into the seminal vesicle]. ⁶¹	Chladt J	4783645	1973
6	[Double kidney left with ectopic orifice of the ureter coming from the upper kidney pole into the urethra]. ⁶¹	Cremer HJ	5063481	1972
7	[Arterial hypertension as the cause of insufficiency of the orifice of the ureter]. ⁶¹	ADAMKIEWICZ K	13859267	1962
8	[Ectopic orifice of the ureter in a little girl. Unsuccessful attempt at conservative surgery. Possible role of rubella in the malfortion]. ⁶¹	CORNUT P...DEFERENNE P	13695612	1960
9	[Incontinence of urine caused by abnormal orifice of the ureter]. ⁶¹	SINGER B	14357685	1954
10	[Case of extravesical orifice of the ureter]. ⁶¹	BUNDIKOV VV	15437630	1950

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Genes for Ureteric Orifice Cancer

Genes related to Ureteric Orifice Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	EFEMP2	EGF Containing Fibulin Extracellular Matrix Protein 2	Protein Coding	5.46	DISEASES inferred ¹⁵
2	CLEC3B	C-Type Lectin Domain Family 3 Member B	Protein Coding	5.26	DISEASES inferred ¹⁵
3	TNXB	Tenascin XB	Protein Coding	5.2	DISEASES inferred ¹⁵
4	FBLN5	Fibulin 5	Protein Coding	5.07	DISEASES inferred ¹⁵
5	SLC7A1	Solute Carrier Family 7 Member 1	Protein Coding	4.66	DISEASES inferred ¹⁵
6	VEGFB	Vascular Endothelial Growth Factor B	Protein Coding	4.57	DISEASES inferred ¹⁵
7	FBN1	Fibrillin 1	Protein Coding	4.42	DISEASES inferred ¹⁵
8	LOX	Lysyl Oxidase	Protein Coding	3.9	DISEASES inferred ¹⁵
9	ELN	Elastin	Protein Coding	3.86	DISEASES inferred ¹⁵
10	NGF	Nerve Growth Factor	Protein Coding	3.6	DISEASES inferred ¹⁵

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Variations for Ureteric Orifice Cancer

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Expression for Ureteric Orifice Cancer

Search GEO for disease gene expression data for Ureteric Orifice Cancer.

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Pathways for Ureteric Orifice Cancer

Pathways related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Phospholipase-C Pathway ⁶³ Show member pathways PTEN Pathway ⁶³	12.55	VEGFB NGF FBN1 ELN EFEMP2
2	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	12.09	TNXB LOX FBN1 FBLN5 ELN EFEMP2
3	Elastic fibre formation ⁶⁵ Show member pathways Molecules associated with elastic fibres ⁶⁵	10.88	LOX FBN1 FBLN5 ELN EFEMP2
4	G-protein signaling_Rap2B regulation pathway ²²	10.46	VEGFB NGF FBN1 ELN EFEMP2

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GO Terms for Ureteric Orifice Cancer

Cellular components related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.76	VEGFB TNXB NGF LOX FBN1 FBLN5
2	extracellular matrix	GO:0031012	9.65	TNXB LOX FBN1 FBLN5 ELN
3	extracellular region	GO:0005576	9.61	VEGFB TNXB NGF LOX FBN1 FBLN5
4	elastic fiber	GO:0071953	9.32	FBLN5 ELN
5	collagen-containing extracellular matrix	GO:0062023	9.1	TNXB FBN1 FBLN5 ELN EFEMP2 CLEC3B

Biological processes related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heart development	GO:0007507	9.43	VEGFB LOX FBN1
2	cellular response to transforming growth factor beta stimulus	GO:0071560	9.4	FBN1 CLEC3B
3	collagen fibril organization	GO:0030199	9.37	TNXB LOX
4	extracellular matrix organization	GO:0030198	9.35	TNXB LOX FBN1 FBLN5 ELN
5	bone mineralization	GO:0030282	9.32	LOX CLEC3B
6	cellular response to organic substance	GO:0071310	9.16	LOX CLEC3B
7	elastic fiber assembly	GO:0048251	8.92	TNXB LOX FBLN5 EFEMP2

Molecular functions related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium ion binding	GO:0005509	9.62	FBN1 FBLN5 EFEMP2 CLEC3B
2	heparin binding	GO:0008201	9.46	VEGFB TNXB FBN1 CLEC3B
3	integrin binding	GO:0005178	9.43	TNXB FBN1 FBLN5
4	extracellular matrix structural constituent	GO:0005201	9.26	TNXB FBN1 ELN EFEMP2
5	extracellular matrix constituent conferring elasticity	GO:0030023	8.8	FBN1 FBLN5 ELN

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Sources for Ureteric Orifice Cancer

¹ BioSystems

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²⁰ GeneAnalytics

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