MCID: URT023
MIFTS: 28

Ureteric Orifice Cancer

Categories: Cancer diseases, Nephrological diseases
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Aliases & Classifications for Ureteric Orifice Cancer

MalaCards integrated aliases for Ureteric Orifice Cancer:

Name: Ureteric Orifice Cancer 11 14
Malignant Neoplasm of Ureteric Orifice of Urinary Bladder 11
Malignant Tumor of Ureteric Orifice 11
Orifice of the Ureter 11

Classifications:



External Ids:

Disease Ontology 11 DOID:11818
ICD9CM 34 188.6
NCIt 49 C12337
SNOMED-CT 68 188245008
ICD10 31 C67.6
UMLS 71 C0153614

Summaries for Ureteric Orifice Cancer

MalaCards based summary: Ureteric Orifice Cancer, also known as malignant neoplasm of ureteric orifice of urinary bladder, is related to tibialis tendinitis and autosomal recessive cutis laxa type iii. An important gene associated with Ureteric Orifice Cancer is CLEC3B (C-Type Lectin Domain Family 3 Member B), and among its related pathways/superpathways are Phospholipase-C Pathway and Signaling by Receptor Tyrosine Kinases. Affiliated tissues include kidney, and related phenotypes are homeostasis/metabolism and muscle

Related Diseases for Ureteric Orifice Cancer

Diseases related to Ureteric Orifice Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 tibialis tendinitis 10.3 TNXB FBLN5
2 autosomal recessive cutis laxa type iii 10.3 FBLN5 EFEMP2
3 cutis laxa, autosomal dominant 2 10.3 FBLN5 EFEMP2
4 cutis laxa, autosomal recessive, type iia 10.3 FBLN5 EFEMP2
5 cutis laxa, autosomal recessive, type iib 10.3 FBLN5 EFEMP2
6 achenbach syndrome 10.2 F3 F2
7 synovial angioma 10.2 F3 F2
8 emphysematous cholecystitis 10.2 F3 F2
9 femoral neuropathy 10.2 F3 F2
10 blue toe syndrome 10.2 F3 F2
11 dic in newborn 10.2 F3 F2
12 giant hemangioma 10.2 F3 F2
13 renal pelvis squamous cell carcinoma 10.2 F3 F2
14 subclavian steal syndrome 10.2 F3 F2
15 waterhouse-friderichsen syndrome 10.2 F3 F2
16 nonbacterial thrombotic endocarditis 10.2 F3 F2
17 livedoid vasculitis 10.2 F3 F2
18 acalculous cholecystitis 10.2 F3 F2
19 hepatic infarction 10.2 F3 F2
20 epidural abscess 10.2 F3 F2
21 lemierre's syndrome 10.2 F3 F2
22 qualitative platelet defect 10.2 F3 F2
23 leech infestation 10.2 F3 F2
24 hemopneumothorax 10.2 F3 F2
25 splenic abscess 10.2 F3 F2
26 branch retinal artery occlusion 10.2 F3 F2
27 retinal drusen 10.2 FBLN5 EFEMP2
28 acute cor pulmonale 10.2 F3 F2
29 acute pulmonary heart disease 10.2 F3 F2
30 kidney cortex necrosis 10.2 F3 F2
31 prothrombin deficiency 10.2 F3 F2
32 cholesterol embolism 10.2 F3 F2
33 acquired von willebrand syndrome 10.2 F3 F2
34 heparin-induced thrombocytopenia 10.2 F3 F2
35 gastric hemangioma 10.2 F3 F2
36 hepatic coma 10.2 F3 F2
37 ankylosing spondylitis 1 10.2 F3 F2
38 sagittal sinus thrombosis 10.2 F3 F2
39 mastoiditis 10.2 F3 F2
40 intracranial embolism 10.2 F3 F2
41 post-thrombotic syndrome 10.2 F3 F2
42 central retinal artery occlusion 10.2 F3 F2
43 splenic sequestration 10.2 F3 F2
44 cauda equina syndrome 10.2 F3 F2
45 tricuspid valve prolapse 10.2 FBN1 EFEMP2
46 intracranial hypotension 10.2 F3 F2
47 splenic infarction 10.2 F3 F2
48 ischemic colitis 10.2 F3 F2
49 active peptic ulcer disease 10.2 F3 F2
50 hypermobile ehlers-danlos syndrome 10.2 TNXB FBN1

Graphical network of the top 20 diseases related to Ureteric Orifice Cancer:



Diseases related to Ureteric Orifice Cancer

Symptoms & Phenotypes for Ureteric Orifice Cancer

MGI Mouse Phenotypes related to Ureteric Orifice Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 ELN F2 F3 FBLN5 FBN1 INS
2 muscle MP:0005369 10.09 EFEMP2 ELN F2 F3 FBLN5 FBN1
3 growth/size/body region MP:0005378 10.07 EFEMP2 F2 F3 FBLN5 FBN1 INS
4 cardiovascular system MP:0005385 10.06 EFEMP2 ELN F2 F3 FBLN5 FBN1
5 respiratory system MP:0005388 9.8 EFEMP2 ELN F2 F3 FBLN5 FBN1
6 skeleton MP:0005390 9.7 CLEC3B EFEMP2 ELN F2 FBN1 INS
7 mortality/aging MP:0010768 9.65 EFEMP2 ELN F2 F3 FBN1 INS
8 integument MP:0010771 9.28 EFEMP2 F2 F3 FBLN5 FBN1 INS

Drugs & Therapeutics for Ureteric Orifice Cancer

Search Clinical Trials, NIH Clinical Center for Ureteric Orifice Cancer

Genetic Tests for Ureteric Orifice Cancer

Anatomical Context for Ureteric Orifice Cancer

Organs/tissues related to Ureteric Orifice Cancer:

MalaCards : Kidney

Publications for Ureteric Orifice Cancer

Articles related to Ureteric Orifice Cancer:

# Title Authors PMID Year
1
[Urinary dribbling in girls: which investigations in 2012?]. 62
23639836 2013
2
Unilateral vesicoureteral reflux and history of contralateral vesicoureteral reflux warranting routine bilateral endoscopic correction. 62
18710733 2008
3
Performing flexible ureteroscopy through a cystoscopy introducer sheath. 62
10475372 1999
4
[Evaluation of the results of surgical treatment of ectopic cysts of the vesical orifice of the ureter in infants as based on the radiologic examination]. 62
6364062 1983
5
[Case report on ectopic orifice of the ureter into the seminal vesicle]. 62
4783645 1973
6
[Double kidney left with ectopic orifice of the ureter coming from the upper kidney pole into the urethra]. 62
5063481 1972
7
[Arterial hypertension as the cause of insufficiency of the orifice of the ureter]. 62
13859267 1962
8
[Ectopic orifice of the ureter in a little girl. Unsuccessful attempt at conservative surgery. Possible role of rubella in the malfortion]. 62
13695612 1960
9
[Incontinence of urine caused by abnormal orifice of the ureter]. 62
14357685 1954
10
[Case of extravesical orifice of the ureter]. 62
15437630 1950

Variations for Ureteric Orifice Cancer

Expression for Ureteric Orifice Cancer

Search GEO for disease gene expression data for Ureteric Orifice Cancer.

Pathways for Ureteric Orifice Cancer

Pathways related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 VEGFB NGF FBN1 ELN EFEMP2
2 12.39 VEGFB NGF INS F3
3
Show member pathways
12.08 TNXB LOX FBN1 FBLN5 ELN EFEMP2
4 11.36 FBN1 FBLN5 ELN
5
Show member pathways
10.93 LOX FBN1 FBLN5 ELN EFEMP2
6 10.46 VEGFB NGF FBN1 ELN EFEMP2

GO Terms for Ureteric Orifice Cancer

Cellular components related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.18 CLEC3B EFEMP2 F2 F3 FBLN5 FBN1
2 extracellular matrix GO:0031012 10.06 TNXB LOX FBN1 FBLN5 ELN EFEMP2
3 extracellular region GO:0005576 10.02 CLEC3B EFEMP2 ELN F2 F3 FBLN5
4 Golgi lumen GO:0005796 9.88 NGF INS F2
5 elastic fiber GO:0071953 9.73 FBLN5 ELN EFEMP2
6 microfibril GO:0001527 9.67 FBN1 EFEMP2
7 collagen-containing extracellular matrix GO:0062023 9.58 TNXB LOX FBN1 FBLN5 F3 F2

Biological processes related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of collagen fibril organization GO:1904028 9.26 TNXB EFEMP2
2 elastic fiber assembly GO:0048251 9.23 TNXB LOX FBLN5 EFEMP2

Molecular functions related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.76 TNXB FBN1 ELN EFEMP2
2 extracellular matrix constituent conferring elasticity GO:0030023 9.43 FBN1 FBLN5 ELN
3 heparin binding GO:0008201 9.4 VEGFB TNXB FBN1 F2 EFEMP2 CLEC3B

Sources for Ureteric Orifice Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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