Ureteric Orifice Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Ureteric Orifice Cancer, also known as malignant neoplasm of ureteric orifice of urinary bladder, is related to tibialis tendinitis and autosomal recessive cutis laxa type iii. An important gene associated with Ureteric Orifice Cancer is CLEC3B (C-Type Lectin Domain Family 3 Member B), and among its related pathways/superpathways are Phospholipase-C Pathway and Signaling by Receptor Tyrosine Kinases. Affiliated tissues include kidney, and related phenotypes are homeostasis/metabolism and muscle

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Related Diseases for Ureteric Orifice Cancer

Diseases related to Ureteric Orifice Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)

#	Related Disease	Score	Top Affiliating Genes
1	tibialis tendinitis	10.3	TNXB FBLN5
2	autosomal recessive cutis laxa type iii	10.3	FBLN5 EFEMP2
3	cutis laxa, autosomal dominant 2	10.3	FBLN5 EFEMP2
4	cutis laxa, autosomal recessive, type iia	10.3	FBLN5 EFEMP2
5	cutis laxa, autosomal recessive, type iib	10.3	FBLN5 EFEMP2
6	achenbach syndrome	10.2	F3 F2
7	synovial angioma	10.2	F3 F2
8	emphysematous cholecystitis	10.2	F3 F2
9	femoral neuropathy	10.2	F3 F2
10	blue toe syndrome	10.2	F3 F2
11	dic in newborn	10.2	F3 F2
12	giant hemangioma	10.2	F3 F2
13	renal pelvis squamous cell carcinoma	10.2	F3 F2
14	subclavian steal syndrome	10.2	F3 F2
15	waterhouse-friderichsen syndrome	10.2	F3 F2
16	nonbacterial thrombotic endocarditis	10.2	F3 F2
17	livedoid vasculitis	10.2	F3 F2
18	acalculous cholecystitis	10.2	F3 F2
19	hepatic infarction	10.2	F3 F2
20	epidural abscess	10.2	F3 F2
21	lemierre's syndrome	10.2	F3 F2
22	qualitative platelet defect	10.2	F3 F2
23	leech infestation	10.2	F3 F2
24	hemopneumothorax	10.2	F3 F2
25	splenic abscess	10.2	F3 F2
26	branch retinal artery occlusion	10.2	F3 F2
27	retinal drusen	10.2	FBLN5 EFEMP2
28	acute cor pulmonale	10.2	F3 F2
29	acute pulmonary heart disease	10.2	F3 F2
30	kidney cortex necrosis	10.2	F3 F2
31	prothrombin deficiency	10.2	F3 F2
32	cholesterol embolism	10.2	F3 F2
33	acquired von willebrand syndrome	10.2	F3 F2
34	heparin-induced thrombocytopenia	10.2	F3 F2
35	gastric hemangioma	10.2	F3 F2
36	hepatic coma	10.2	F3 F2
37	ankylosing spondylitis 1	10.2	F3 F2
38	sagittal sinus thrombosis	10.2	F3 F2
39	mastoiditis	10.2	F3 F2
40	intracranial embolism	10.2	F3 F2
41	post-thrombotic syndrome	10.2	F3 F2
42	central retinal artery occlusion	10.2	F3 F2
43	splenic sequestration	10.2	F3 F2
44	cauda equina syndrome	10.2	F3 F2
45	tricuspid valve prolapse	10.2	FBN1 EFEMP2
46	intracranial hypotension	10.2	F3 F2
47	splenic infarction	10.2	F3 F2
48	ischemic colitis	10.2	F3 F2
49	active peptic ulcer disease	10.2	F3 F2
50	hypermobile ehlers-danlos syndrome	10.2	TNXB FBN1

Graphical network of the top 20 diseases related to Ureteric Orifice Cancer:

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Symptoms & Phenotypes for Ureteric Orifice Cancer

MGI Mouse Phenotypes related to Ureteric Orifice Cancer:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.1	ELN F2 F3 FBLN5 FBN1 INS
2	muscle	MP:0005369	10.09	EFEMP2 ELN F2 F3 FBLN5 FBN1
3	growth/size/body region	MP:0005378	10.07	EFEMP2 F2 F3 FBLN5 FBN1 INS
4	cardiovascular system	MP:0005385	10.06	EFEMP2 ELN F2 F3 FBLN5 FBN1
5	respiratory system	MP:0005388	9.8	EFEMP2 ELN F2 F3 FBLN5 FBN1
6	skeleton	MP:0005390	9.7	CLEC3B EFEMP2 ELN F2 FBN1 INS
7	mortality/aging	MP:0010768	9.65	EFEMP2 ELN F2 F3 FBN1 INS
8	integument	MP:0010771	9.28	EFEMP2 F2 F3 FBLN5 FBN1 INS

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Drugs & Therapeutics for Ureteric Orifice Cancer

Search Clinical Trials, NIH Clinical Center for Ureteric Orifice Cancer

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Genetic Tests for Ureteric Orifice Cancer

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Anatomical Context for Ureteric Orifice Cancer

Organs/tissues related to Ureteric Orifice Cancer:

MalaCards : Kidney

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Publications for Ureteric Orifice Cancer

Articles related to Ureteric Orifice Cancer:

#	Title	Authors	PMID	Year
1	[Urinary dribbling in girls: which investigations in 2012?]. ⁶²	Grimaldi C...Petit P	23639836	2013
2	Unilateral vesicoureteral reflux and history of contralateral vesicoureteral reflux warranting routine bilateral endoscopic correction. ⁶²	Chertin B...Farkas A	18710733	2008
3	Performing flexible ureteroscopy through a cystoscopy introducer sheath. ⁶²	Kim HL...Gerber GS	10475372	1999
4	[Evaluation of the results of surgical treatment of ectopic cysts of the vesical orifice of the ureter in infants as based on the radiologic examination]. ⁶²	Kaniewska A...Grabowski K	6364062	1983
5	[Case report on ectopic orifice of the ureter into the seminal vesicle]. ⁶²	Chladt J	4783645	1973
6	[Double kidney left with ectopic orifice of the ureter coming from the upper kidney pole into the urethra]. ⁶²	Cremer HJ	5063481	1972
7	[Arterial hypertension as the cause of insufficiency of the orifice of the ureter]. ⁶²	ADAMKIEWICZ K	13859267	1962
8	[Ectopic orifice of the ureter in a little girl. Unsuccessful attempt at conservative surgery. Possible role of rubella in the malfortion]. ⁶²	CORNUT P...DEFERENNE P	13695612	1960
9	[Incontinence of urine caused by abnormal orifice of the ureter]. ⁶²	SINGER B	14357685	1954
10	[Case of extravesical orifice of the ureter]. ⁶²	BUNDIKOV VV	15437630	1950

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Genes for Ureteric Orifice Cancer

Genes related to Ureteric Orifice Cancer (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CLEC3B	C-Type Lectin Domain Family 3 Member B	Protein Coding	4.82	DISEASES inferred ¹⁴
2	EFEMP2	EGF Containing Fibulin Extracellular Matrix Protein 2	Protein Coding	4.74	DISEASES inferred ¹⁴
3	TNXB	Tenascin XB	Protein Coding	4.53	DISEASES inferred ¹⁴
4	FBLN5	Fibulin 5	Protein Coding	4.45	DISEASES inferred ¹⁴
5	F3	Coagulation Factor III, Tissue Factor	Protein Coding	4.02	DISEASES inferred ¹⁴
6	F2	Coagulation Factor II, Thrombin	Protein Coding	3.94	DISEASES inferred ¹⁴
7	VEGFB	Vascular Endothelial Growth Factor B	Protein Coding	3.82	DISEASES inferred ¹⁴
8	FBN1	Fibrillin 1	Protein Coding	3.66	DISEASES inferred ¹⁴
9	LOX	Lysyl Oxidase	Protein Coding	3.13	DISEASES inferred ¹⁴
10	ELN	Elastin	Protein Coding	3.11	DISEASES inferred ¹⁴
11	NGF	Nerve Growth Factor	Protein Coding	2.92	DISEASES inferred ¹⁴
12	INS	Insulin	Protein Coding	2.89	DISEASES inferred ¹⁴

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Variations for Ureteric Orifice Cancer

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Expression for Ureteric Orifice Cancer

Search GEO for disease gene expression data for Ureteric Orifice Cancer.

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Pathways for Ureteric Orifice Cancer

Pathways related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	12.61	VEGFB NGF FBN1 ELN EFEMP2
2	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.39	VEGFB NGF INS F3
3	Extracellular matrix organization ⁶⁶ Show member pathways Degradation of the extracellular matrix ⁶⁶	12.08	TNXB LOX FBN1 FBLN5 ELN EFEMP2
4	7q11.23 copy number variation syndrome ⁷⁴	11.36	FBN1 FBLN5 ELN
5	Elastic fibre formation ⁶⁶ Show member pathways Molecules associated with elastic fibres ⁶⁶	10.93	LOX FBN1 FBLN5 ELN EFEMP2
6	G-protein signaling_Rap2B regulation pathway ²²	10.46	VEGFB NGF FBN1 ELN EFEMP2

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GO Terms for Ureteric Orifice Cancer

Cellular components related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	10.18	CLEC3B EFEMP2 F2 F3 FBLN5 FBN1
2	extracellular matrix	GO:0031012	10.06	TNXB LOX FBN1 FBLN5 ELN EFEMP2
3	extracellular region	GO:0005576	10.02	CLEC3B EFEMP2 ELN F2 F3 FBLN5
4	Golgi lumen	GO:0005796	9.88	NGF INS F2
5	elastic fiber	GO:0071953	9.73	FBLN5 ELN EFEMP2
6	microfibril	GO:0001527	9.67	FBN1 EFEMP2
7	collagen-containing extracellular matrix	GO:0062023	9.58	TNXB LOX FBN1 FBLN5 F3 F2

Biological processes related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of collagen fibril organization	GO:1904028	9.26	TNXB EFEMP2
2	elastic fiber assembly	GO:0048251	9.23	TNXB LOX FBLN5 EFEMP2

Molecular functions related to Ureteric Orifice Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent	GO:0005201	9.76	TNXB FBN1 ELN EFEMP2
2	extracellular matrix constituent conferring elasticity	GO:0030023	9.43	FBN1 FBLN5 ELN
3	heparin binding	GO:0008201	9.4	VEGFB TNXB FBN1 F2 EFEMP2 CLEC3B

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Sources for Ureteric Orifice Cancer

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

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⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

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¹¹ Disease Ontology

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¹⁵ DrugBank

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¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: URT023 MIFTS: 28	Ureteric Orifice Cancer Categories: Cancer diseases, Nephrological diseases	Data Licensing For inquiries, contact: [email protected]
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