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MCID: URT014
MIFTS: 38

Ureterolithiasis

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ureterolithiasis

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MalaCards integrated aliases for Ureterolithiasis:

Name: Ureterolithiasis 12 44 15 73
Calculus of Ureter 12
Ureteric Calculus 12
Ureteral Calculi 73
Ureteric Stone 12

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:14146
ICD9CM 35 592.1
MeSH 44 D053039
NCIt 50 C114696
SNOMED-CT 68 31054009 95573009
ICD10 33 N20.1
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Summaries for Ureterolithiasis

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MalaCards based summary : Ureterolithiasis, also known as calculus of ureter, is related to nephrolithiasis, calcium oxalate and nephrolithiasis. An important gene associated with Ureterolithiasis is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Calcium signaling pathway and Salivary secretion. The drugs Tamsulosin and Alfuzosin have been mentioned in the context of this disorder. Affiliated tissues include kidney and adrenal gland, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 76 Kidney stone disease, also known as urolithiasis, is when a solid piece of material (kidney stone)... more...

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Related Diseases for Ureterolithiasis

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Diseases related to Ureterolithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 nephrolithiasis, calcium oxalate 11.1
2 nephrolithiasis 10.3
3 ureterocele 9.9
4 hydronephrosis 9.9
5 perinephritis 9.9
6 appendicitis 9.9
7 transitional cell carcinoma 9.8
8 cystinuria 9.8
9 adenine phosphoribosyltransferase deficiency 9.8
10 atrial fibrillation 9.8
11 mucositis 9.8
12 endometriosis 9.8
13 anuria 9.8
14 ureteral obstruction 9.8
15 dihydroxyadeninuria 9.8
16 renal dysplasia 9.8
17 bladder disease 9.7 CHRM3 TRPV1
18 pulmonary disease, chronic obstructive 9.4 CHRM3 TRPV1

Comorbidity relations with Ureterolithiasis via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Bladder Neck Obstruction
Hydronephrosis Nephrolithiasis, Uric Acid
Nephrolithiasis, X-Linked Recessive, with Renal Failure Paralytic Ileus
Prostate Cancer Prostatic Hypertrophy
Pyelonephritis Urethral Calculus
Urethral Stricture Urinary Tract Obstruction

Graphical network of the top 20 diseases related to Ureterolithiasis:



Diseases related to Ureterolithiasis
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Symptoms & Phenotypes for Ureterolithiasis

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MGI Mouse Phenotypes related to Ureterolithiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 ADRA1A AKAP5 APRT CHRM3 TRPV1
2 homeostasis/metabolism MP:0005376 9.43 TRPV1 ADRA1A AKAP5 APRT CHRM3 SLC12A3
3 renal/urinary system MP:0005367 9.02 ADRA1A APRT CHRM3 SLC12A3 TRPV1
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Drugs & Therapeutics for Ureterolithiasis

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Drugs for Ureterolithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamsulosin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 106133-20-4 129211
2
Alfuzosin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 81403-80-7 2092
3
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
4
Morphine Approved, Investigational Phase 4 57-27-2 5288826
5 Nefopam Approved, Investigational Phase 4 13669-70-0
6
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
7
Silodosin Approved Phase 4,Phase 3,Phase 2 160970-54-7
8
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
9
Diclofenac Approved, Vet_approved Phase 4,Not Applicable 15307-86-5 3033
10
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
11
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
12 Naftopidil Investigational Phase 4,Phase 3 57149-07-2
13 Adrenergic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
14 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
15 Adrenergic alpha-Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
16 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
17 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
18 Antihypertensive Agents Phase 4,Phase 3
19 calcium channel blockers Phase 4,Phase 3
20 Calcium, Dietary Phase 4,Phase 3
21 Platelet Aggregation Inhibitors Phase 4,Phase 3
22 Analgesics Phase 4,Phase 3,Not Applicable
23 Analgesics, Non-Narcotic Phase 4,Not Applicable
24 Analgesics, Opioid Phase 4,Not Applicable
25 Anti-Inflammatory Agents Phase 4,Not Applicable
26 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Not Applicable
27 Antirheumatic Agents Phase 4,Not Applicable
28 Central Nervous System Depressants Phase 4,Not Applicable
29 Cyclooxygenase Inhibitors Phase 4,Not Applicable
30 Ketorolac Tromethamine Phase 4
31 Narcotics Phase 4,Not Applicable
32 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
33 Vasodilator Agents Phase 4,Phase 3
34 Antipyretics Phase 4
35 Pharmaceutical Solutions Phase 4,Not Applicable
36 Phosphodiesterase 5 Inhibitors Phase 4
37 Phosphodiesterase Inhibitors Phase 4
38 Sildenafil Citrate Phase 4 171599-83-0
39 Citrate Nutraceutical Phase 4
40
Doxazosin Approved Phase 3 74191-85-8 3157
41
Nifedipine Approved Phase 3 21829-25-4 4485
42
Prazosin Approved Phase 3 19216-56-9 4893
43
Aceclofenac Approved, Investigational Phase 3 89796-99-6
44
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
45 Tocolytic Agents Phase 3
46 Mirabegron Approved Phase 2 223673-61-8 9865528
47 Adrenergic Agonists Phase 2
48 Adrenergic beta-3 Receptor Agonists Phase 2
49 Adrenergic beta-Agonists Phase 2
50
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676

Interventional clinical trials:

(show top 50) (show all 72)
# Name Status NCT ID Phase Drugs
1 The Use of Medical-Expulsive Therapy With Alfuzocine xl 10mg x1/d for Distal Ureterolithiasis.a Randomized Prospective Study Unknown status NCT00489112 Phase 4 Alfuzocine XL 10 mg once a day
2 Efficacy of Tamsulosin Oral-controlled Absorption System (OCAS) in the Treatment of Distal Ureteral Stones Unknown status NCT01167062 Phase 4 Tamsulosin Hydrochloride OCAS 0.4 mg
3 The Efficacy of Alpha-blockers for Expulsion of Distal Ureteral Stones Unknown status NCT00451061 Phase 4 Alfuzosin;Tamsulosin
4 Naftopidil 75mg for Improving Clearance of Urinary Stones Unknown status NCT02011737 Phase 4 naftopidil 75mg
5 Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic Unknown status NCT01543165 Phase 4 Ketorolac and nefopam balanced analgesia;Balanced analgesia using ketorolac and morphine;Pain control with single analgesics (ketorolac)
6 Nefopam and Morphine Consumption in the Treatment of Ureteral Calculi Completed NCT00639574 Phase 4 Néfopam
7 Efficacy and Safety of Silodosin in the Treatment of Natural Expulsion in Patients With Ureteral Stones Completed NCT01533389 Phase 4 Silodosin;Placebo
8 Tamsulosin for Urolithiasis in the Emergency Dept Completed NCT00382265 Phase 4 tamsulosin
9 Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management Completed NCT02187614 Phase 4 Diclofenac;Morphine;Paracetamol;Placebos
10 Treatment of Upper Ureteric Stones Recruiting NCT02469766 Phase 4
11 Phosphodiesterase 5 Inhibitors (PDE5i) (Sildenafil) as Medical Expulsive Therapy in Distal Ureteral Stones Active, not recruiting NCT02519153 Phase 4 Sildenafil
12 Trial of Tadalafil, Tamsulosin and Combination for Access Sheath Deployment Enrolling by invitation NCT03229889 Phase 4 Cialis 5Mg Tablet;Flomax 0.4Mg Capsule;Placebo
13 Silodosin Versus Tamsulosin for Treatment of Ureteral Stones Terminated NCT02369744 Phase 4 Silodosin;Tamsulosin
14 Celecoxib (Celebrex) in the Management of Acute Renal Colic Withdrawn NCT00304317 Phase 4 celecoxib
15 Alfuzosin for Medical Expulsion Therapy of Ureteral Stones Unknown status NCT00713739 Phase 3 Alfuzosin;nifedipine;doxazosin;prazosin
16 Evaluation of Tamsulosin in the Treatment of Ureteral Stones Completed NCT00151567 Phase 3 Tamsulosin;Placebo
17 Medical Expulsive Therapy for Ureter Stone Using Naftopidil Completed NCT01952314 Phase 3 Naftopidil 75mg;Placebo for Naftopidil;Standard treatment
18 Alfuzosin Hydrochloride to Promote Passage of Distal Ureteral Calculi Completed NCT00177086 Phase 3
19 Effectiveness of Silodosin in Medical Expulsive Therapy for Ureteral Pelvic Stone From 4 to 10 mm. Terminated NCT02090439 Phase 3 Silodosin
20 Use of Alfuzosin in Stone Treatment With ESWL Withdrawn NCT00388271 Phase 3 Alfuzosin (Xatral);standard treatment
21 Comparing Patients After ESWL Treated With Ureteral Stents Versus Expulsion Therapy With Tamsulosin Unknown status NCT00478998 Phase 2 Tamsulosin
22 Does Treatment With Alfuzosin Increase Success Rates of (SWL) Shock Wave Lithotripsy Unknown status NCT00409227 Phase 2 Alpha blocker-alfuzosin;placebo
23 Study of Silodosin to Facilitate Passage of Urinary Stones Completed NCT01144949 Phase 2 silodosin;placebo
24 A Dose-finding Study of Silodosin in Patients With Urinary Calculi Completed NCT01539265 Phase 2 silodosin;silodosin;placebo
25 Mirabegron as Medical Expulsive Therapy (MET) for Ureteral Stones and Ureteral Stent Pain Not yet recruiting NCT02744430 Phase 2 Mirabegron
26 Feasibility Study of the Uriprene Stent Following Uncomplicated Ureteroscopy Completed NCT02032316 Phase 1
27 Silent Ureteral Stone: Impact on Renal Function and Kidney Anatomy Unknown status NCT01884870 Not Applicable
28 US-Non Contrast Computed Tomography Real-time Fusion for Urinary Stones Follow up Unknown status NCT02539004
29 Comparative Treatment Study in Patients With Lower Ureteral Stones Unknown status NCT00397397
30 Shockwave Lithotripsy (SWL) Under Selective, General Anesthesia. Unknown status NCT01008267
31 Prospective Comparison Between Different Laser Settings for Ureteral \ Kidney Stones Treatment During Ureteroscopy Unknown status NCT02279927 Not Applicable
32 Intraureteral Lidocaine for Post-Ureteroscopy Pain Unknown status NCT01450566 Not Applicable Lidocaine;Saline
33 Delayed or Direct Ureteroscopy in the Treatment of Pediatric Calcular Anuria Unknown status NCT02139059 Not Applicable
34 ESWL vs URS in Management of Upper Third Ureteric Calculi Completed NCT03559738
35 The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients Completed NCT00600405 Not Applicable tamsulosin;Standard therapy with ibuprofen and oxycodone.
36 Study on 'The Use of Non-contrast Helical Computerized Tomogram in Predicting Treatment Outcomes of Upper Ureteric Stone by Extracorporeal Shock Wave Lithotripsy Using the Sonolith 4000+ Lithotripter' Completed NCT00517205
37 Medical Expulsive Therapy of Single Distal Ureteral Stones Completed NCT00831701 Not Applicable Tamsulosin;Placebo
38 The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients Completed NCT00448123 Not Applicable Tamsulosin;Placebo
39 Management of Ureteral Calculi Using Ultrasound Guidance: A Radiation Free Approach Completed NCT01792765 Not Applicable
40 Effect of Tamsulosin on Stone Expulsion and Pain Resolution in ED Patients With Ureterolithiasis Completed NCT00762424 Not Applicable Flowmax;placebo
41 Is Prophylactic Antibiotics Necessary In Otherwise Healthy Adult Patients Undergoing Ureteroscopic Procedures for Ureteral Stones? Completed NCT02635490
42 Use of the PercSys MicroStent Device to Alleviate Ureteral Stone Symptoms and Hydronephrosis Completed NCT01637519
43 Ureteral Stents Versus Percutaneous Nephrostomy for Initial Urinary Drainage Completed NCT02055430 Not Applicable
44 Role of Flexible Cystoscopy in Laparoscopic Stone Surgery Completed NCT01277198
45 The Usefulness of Flexible Cystoscopy for Preventing Double-J Stent Malposition After Laparoscopic Ureterolithotomy Completed NCT03150446 Not Applicable
46 Conditional Imaging Prescription Strategy for Exploration of Acute Uncomplicated Renal Colic Completed NCT02878148 Not Applicable
47 Management of Fragments During Ureteroscopy Completed NCT00637650 Not Applicable
48 Evaluating Ureteral Length Using Computed Tomography (CT) Completed NCT01542593 Not Applicable
49 Analysis the Relationship Between the Abdomen CT and Outcomes in Acute Urinary Stone Patients Completed NCT02983409
50 Escalating, Constant and Reduction Energy Output in SWL for Renal Stones Completed NCT02037906 Not Applicable

Search NIH Clinical Center for Ureterolithiasis

Cochrane evidence based reviews: ureterolithiasis

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Genetic Tests for Ureterolithiasis

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Anatomical Context for Ureterolithiasis

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MalaCards organs/tissues related to Ureterolithiasis:

41
Kidney, Adrenal Gland
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Publications for Ureterolithiasis

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Articles related to Ureterolithiasis:

(show top 50) (show all 96)
# Title Authors Year
1
Bilateral ureterolithiasis: A true positive and false negative PoCUS exam in a patient with renal colic. ( 29606152 )
2018
2
Perinephric fat stranding is associated with elevated creatinine among patients with acutely obstructing ureterolithiasis. ( 29943669 )
2018
3
Spontaneous proximal ureteric rupture secondary to ureterolithiasis. ( 28069871 )
2017
4
Ureterolithiasis: Management in an environment with limited facilities. ( 28513524 )
2017
5
Comparison between double-pigtail ureteral stents and ureteral bypass devices for treatment of ureterolithiasis in cats. ( 28763282 )
2017
6
Comparison of prone vs. supineA unenhanced CT imaging in patients with clinically suspected ureterolithiasis. ( 27670877 )
2016
7
Medical Expulsive Therapy for Ureterolithiasis: The EAU Recommendations in 2016. ( 27506951 )
2016
8
Beyond ureterolithiasis: gamut of abnormalities affecting the ureter. ( 27317212 )
2016
9
Is hydronephrosis on ultrasound predictive of ureterolithiasis in patients with renal colic? ( 27154825 )
2016
10
Management of Ureterolithiasis in a Patient with Crossed Unfused Renal Ectopia. ( 27403369 )
2016
11
Clinical relevance of seasonal changes in the prevalence of ureterolithiasis in the diagnosis of renal colic. ( 27314408 )
2016
12
Long-term Adverse Effects of Extracorporeal Shock-wave Lithotripsy for Nephrolithiasis and Ureterolithiasis: A Systematic Review. ( 25917723 )
2015
13
The use of alpha-1 adrenergic blockers in children with distal ureterolithiasis: a systematic review and meta-analysis. ( 26717117 )
2015
14
Tamsulosin for treatment of unilateral distal ureterolithiasis: a systematic review and meta-analysis. ( 24852587 )
2014
15
Indwelling double pigtail ureteral stent combined or not with surgery for feline ureterolithiasis: complications and outcome in 15 cases. ( 24305471 )
2013
16
Pyeloduodenal fistula due to proximal ureterolithiasis and its successful conservative management. ( 24051966 )
2013
17
Terpene compound drug as medical expulsive therapy for ureterolithiasis: a meta-analysis. ( 23503876 )
2013
18
Re: terpene compound drug as medical expulsive therapy for ureterolithiasis: a meta-analysis. ( 23421365 )
2013
19
Tamsulosin for treatment of unilateral distal ureterolithiasis: a systematic review and meta-analysis. ( 23870675 )
2013
20
Anuria and abdominal pain induced by ceftriaxone-associated ureterolithiasis in adults. ( 23180444 )
2013
21
Bladder bulge: unifying old and new sonographic bladder wall abnormalities in ureterolithiasis. ( 23358632 )
2012
22
Bedside renal ultrasound in the evaluation of suspected ureterolithiasis. ( 21185667 )
2012
23
Unusual presentation of bilateral ureteroceles with ureterolithiasis in a patient after robotic prostatectomy. ( 22546412 )
2012
24
Synchronous obstructive ureterolithiasis and acute appendicitis. ( 24960802 )
2012
25
Endoscopic holmium laser treatment for ureterolithiasis. ( 24578918 )
2012
26
Health related quality of life in ureteral stone patients: post-ureterolithiasis. ( 21461963 )
2011
27
Extracorporeal shock wave lithotripsy-induced retroperitoneal hemorrhage in a case of upper ureteral calculus with angiomyolipoma. ( 21404208 )
2011
28
Ureterolithiasis in children. ( 21585171 )
2011
29
The effect of alpha-blockade in emergency department patients with ureterolithiasis. ( 19217243 )
2010
30
Submucosal ureteric calculus mimicking transitional cell carcinoma. ( 20089036 )
2010
31
The sensitivity of transabdominal ultrasound in the diagnosis of ureterolithiasis. ( 21203595 )
2010
32
A case of calcified ureteritis cystica: an indiscernible condition from ureterolithiasis. ( 19655701 )
2009
33
Acute onset of renal colic from bilateral ureterolithiasis: a case report. ( 19829794 )
2009
34
Type IV ureteral triplication associated with ipsilateral ureterocele with ureterolithiasis and contralateral duplication with an ectopic ureteral orifice. ( 19138195 )
2008
35
Conventional and reduced radiation dose of 16-MDCT for detection of nephrolithiasis and ureterolithiasis. ( 18094305 )
2008
36
Usefulness of urinalysis in following patients with distal ureterolithiasis. ( 18578655 )
2008
37
The utility of unenhanced helical CT in assessing the frequency of ureterolithiasis in Saudi patients. ( 18246228 )
2008
38
Cost-effectiveness analysis (CEA) of intravenous urography (IVU) and unenhanced multidetector computed tomography (MDCT) for initial investigation of suspected acute ureterolithiasis. ( 18300151 )
2008
39
Comparison between ultrasound and noncontrast helical computed tomography for identification of acute ureterolithiasis in a teaching hospital setting. ( 17625708 )
2007
40
Ureteroscopical treatment of ureterolithiasis in childhood. Our experience. ( 16752883 )
2006
41
Electro-acupuncture treatment for the upper segment ureterolithiasis under B-ultrasonography. ( 15889513 )
2005
42
Medical-expulsive therapy for distal ureterolithiasis: randomized prospective study on role of corticosteroids used in combination with tamsulosin-simplified treatment regimen and health-related quality of life. ( 16230122 )
2005
43
Ureterolithiasis after Cohen re-implantation--case report. ( 15070415 )
2004
44
Diagnostic value of attenuation measurements of the kidney on unenhanced helical CT of obstructive ureterolithiasis. ( 15100127 )
2004
45
Unenhanced helical CT of ureterolithiasis: incidence of secondary urinary tract findings. ( 15058632 )
2004
46
Unenhanced helical CT scan for ureterolithiasis. ( 15321049 )
2004
47
Pneumatic lithotripsy for ureterolithiasis: clinical analysis of 512 cases. ( 12865242 )
2003
48
Helical CT for nephrolithiasis and ureterolithiasis: comparison of conventional and reduced radiation-dose techniques. ( 14526095 )
2003
49
Acute ureterolithiasis: incidence of secondary signs on unenhanced helical CT and influence on patient management. ( 14654033 )
2003
50
Speedy elimination of ureterolithiasis in lower part of ureters with the alpha 1-blocker--Tamsulosin. ( 12549635 )
2002
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Variations for Ureterolithiasis

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Expression for Ureterolithiasis

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Search GEO for disease gene expression data for Ureterolithiasis.
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Pathways for Ureterolithiasis

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Pathways related to Ureterolithiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Calcium signaling pathway 37
Show member pathways
 11.43 ADRA1A CHRM3
2
Salivary secretion 37
Show member pathways
 11.17 ADRA1A CHRM3
3
Monoamine GPCRs 1
Show member pathways
 10.68 ADRA1A CHRM3
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GO Terms for Ureterolithiasis

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Cellular components related to Ureterolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.92 ADRA1A CHRM3 SLC12A3 TRPV1

Biological processes related to Ureterolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.26 ADRA1A TRPV1
2 regulation of vasoconstriction GO:0019229 9.16 ADRA1A CHRM3
3 positive regulation of smooth muscle contraction GO:0045987 8.96 ADRA1A CHRM3
4 smooth muscle contraction GO:0006939 8.62 ADRA1A CHRM3
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Sources for Ureterolithiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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