MCID: URT014
MIFTS: 34

Ureterolithiasis

Categories: Nephrological diseases

Aliases & Classifications for Ureterolithiasis

MalaCards integrated aliases for Ureterolithiasis:

Name: Ureterolithiasis 12 44 15 73
Calculus of Ureter 12
Ureteric Calculus 12
Ureteral Calculi 73
Ureteric Stone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14146
ICD9CM 35 592.1
MeSH 44 D053039
NCIt 50 C114696
SNOMED-CT 68 31054009 95573009
ICD10 33 N20.1

Summaries for Ureterolithiasis

MalaCards based summary : Ureterolithiasis, also known as calculus of ureter, is related to nephrolithiasis, calcium oxalate and nephrolithiasis. An important gene associated with Ureterolithiasis is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). The drugs Tamsulosin and Alfuzosin have been mentioned in the context of this disorder. Affiliated tissues include kidney, adrenal gland and bone, and related phenotypes are behavior/neurological and renal/urinary system

Wikipedia : 76 Kidney stone disease, also known as urolithiasis, is when a solid piece of material (kidney stone)... more...

Related Diseases for Ureterolithiasis

Diseases related to Ureterolithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 nephrolithiasis, calcium oxalate 11.5
2 nephrolithiasis 10.4
3 appendicitis 10.2
4 urinary tract obstruction 10.1
5 hydronephrosis 10.1
6 pyelonephritis 10.0
7 exstrophy of bladder 9.9
8 transitional cell carcinoma 9.9
9 angiomyolipoma 9.9
10 embryoma 9.9
11 ureterocele 9.9
12 cystinuria 9.9
13 adenine phosphoribosyltransferase deficiency 9.9
14 atrial fibrillation 9.9
15 papilloma 9.9
16 endometriosis 9.9
17 anuria 9.9
18 ureteral obstruction 9.9
19 dihydroxyadeninuria 9.9
20 renal dysplasia 9.9
21 fibromuscular dysplasia 9.9
22 thrombocytopenic purpura, autoimmune 9.9
23 vesicoureteral reflux 1 9.9
24 horns in sheep 9.9
25 brittle bone disorder 9.9
26 end stage renal failure 9.9
27 morbid obesity 9.9
28 systemic mastocytosis 9.9
29 small cell carcinoma 9.9
30 thrombosis 9.9
31 azoospermia 9.9
32 cystitis 9.9
33 ankylosis 9.9
34 gastroenteritis 9.9
35 glandular cystitis 9.9
36 teratoma 9.9
37 purpura 9.9
38 mastocytosis 9.9
39 uremia 9.9
40 acute pyelonephritis 9.9
41 adenoma 9.9
42 nephrogenic adenoma 9.9
43 actinomycosis 9.9

Comorbidity relations with Ureterolithiasis via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Bladder Neck Obstruction
Hydronephrosis Nephrolithiasis, Uric Acid
Nephrolithiasis, X-Linked Recessive, with Renal Failure Paralytic Ileus
Prostate Cancer Prostatic Hypertrophy
Pyelonephritis Urethral Calculus
Urethral Stricture Urinary Tract Obstruction

Graphical network of the top 20 diseases related to Ureterolithiasis:



Diseases related to Ureterolithiasis

Symptoms & Phenotypes for Ureterolithiasis

MGI Mouse Phenotypes related to Ureterolithiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 ADRA1A AKAP5 APBB1 APRT TRPV1
2 renal/urinary system MP:0005367 8.92 ADRA1A APRT SLC12A3 TRPV1

Drugs & Therapeutics for Ureterolithiasis

Drugs for Ureterolithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamsulosin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 106133-20-4 129211
2
Alfuzosin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 81403-80-7 2092
3
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
4
Morphine Approved, Investigational Phase 4 57-27-2 5288826
5 Nefopam Approved, Investigational Phase 4 13669-70-0
6
Diclofenac Approved, Vet_approved Phase 4,Not Applicable 15307-86-5 3033
7
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
8
Silodosin Approved Phase 4,Phase 3,Phase 2 160970-54-7
9
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
10
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
11
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
12
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
13 Naftopidil Investigational Phase 4,Phase 3 57149-07-2
14 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
15 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
16 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
17 Adrenergic alpha-Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
18 Adrenergic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
19 calcium channel blockers Phase 4,Phase 3
20 Antihypertensive Agents Phase 4,Phase 3
21 Calcium, Dietary Phase 4,Phase 3
22 Platelet Aggregation Inhibitors Phase 4,Phase 3
23 Ketorolac Tromethamine Phase 4
24 Analgesics, Non-Narcotic Phase 4,Not Applicable
25 Analgesics, Opioid Phase 4,Not Applicable
26 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Not Applicable
27 Central Nervous System Depressants Phase 4,Not Applicable
28 Analgesics Phase 4,Phase 3,Not Applicable
29 Narcotics Phase 4,Not Applicable
30 Antirheumatic Agents Phase 4,Not Applicable
31 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
32 Anti-Inflammatory Agents Phase 4,Not Applicable
33 Cyclooxygenase Inhibitors Phase 4,Not Applicable
34 Vasodilator Agents Phase 4,Phase 3
35 Pharmaceutical Solutions Phase 4,Not Applicable
36 Antipyretics Phase 4,Not Applicable
37 Anti-Infective Agents Phase 4,Not Applicable
38 Antibiotics, Antitubercular Phase 4,Not Applicable
39 Anti-Bacterial Agents Phase 4,Not Applicable
40 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
41 Cytochrome P-450 Enzyme Inhibitors Phase 4
42 Topoisomerase Inhibitors Phase 4
43 Cyclooxygenase 2 Inhibitors Phase 4,Not Applicable
44 Sildenafil Citrate Phase 4 171599-83-0
45 Phosphodiesterase Inhibitors Phase 4
46 Phosphodiesterase 5 Inhibitors Phase 4
47 Citrate Phase 4
48
Prazosin Approved Phase 3 19216-56-9 4893
49
Nifedipine Approved Phase 3 21829-25-4 4485
50
Doxazosin Approved Phase 3 74191-85-8 3157

Interventional clinical trials:

(show top 50) (show all 81)
# Name Status NCT ID Phase Drugs
1 Treatment of Upper Ureteric Stones Unknown status NCT02469766 Phase 4
2 The Use of Medical-Expulsive Therapy With Alfuzocine xl 10mg x1/d for Distal Ureterolithiasis.a Randomized Prospective Study Unknown status NCT00489112 Phase 4 Alfuzocine XL 10 mg once a day
3 Efficacy of Tamsulosin Oral-controlled Absorption System (OCAS) in the Treatment of Distal Ureteral Stones Unknown status NCT01167062 Phase 4 Tamsulosin Hydrochloride OCAS 0.4 mg
4 The Efficacy of Alpha-blockers for Expulsion of Distal Ureteral Stones Unknown status NCT00451061 Phase 4 Alfuzosin;Tamsulosin
5 Naftopidil 75mg for Improving Clearance of Urinary Stones Unknown status NCT02011737 Phase 4 naftopidil 75mg
6 Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic Unknown status NCT01543165 Phase 4 Ketorolac and nefopam balanced analgesia;Balanced analgesia using ketorolac and morphine;Pain control with single analgesics (ketorolac)
7 Nefopam and Morphine Consumption in the Treatment of Ureteral Calculi Completed NCT00639574 Phase 4 Néfopam
8 Efficacy and Safety of Silodosin in the Treatment of Natural Expulsion in Patients With Ureteral Stones Completed NCT01533389 Phase 4 Silodosin;Placebo
9 Tamsulosin for Urolithiasis in the Emergency Dept Completed NCT00382265 Phase 4 tamsulosin
10 Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management Completed NCT02187614 Phase 4 Diclofenac;Morphine;Paracetamol;Placebos
11 Antibiotic Prophylaxis Before Shock Wave Lithotripsy Recruiting NCT03692715 Phase 4 Ciprofloxacin;Placebo
12 Tamsulosin as Adjuvant Treatment Prior to Endoscopic Ureterolithotomy Recruiting NCT03614052 Phase 4 Tamsulosin Hydrochloride 0.4 MG;Placebo Oral Tablet
13 Phosphodiesterase 5 Inhibitors (PDE5i) (Sildenafil) as Medical Expulsive Therapy in Distal Ureteral Stones Active, not recruiting NCT02519153 Phase 4 Sildenafil
14 Trial of Tadalafil, Tamsulosin and Combination for Access Sheath Deployment Enrolling by invitation NCT03229889 Phase 4 Cialis 5Mg Tablet;Flomax 0.4Mg Capsule;Placebo
15 Silodosin Versus Tamsulosin for Treatment of Ureteral Stones Terminated NCT02369744 Phase 4 Silodosin;Tamsulosin
16 Celecoxib (Celebrex) in the Management of Acute Renal Colic Withdrawn NCT00304317 Phase 4 celecoxib
17 Alfuzosin for Medical Expulsion Therapy of Ureteral Stones Unknown status NCT00713739 Phase 3 Alfuzosin;nifedipine;doxazosin;prazosin
18 Evaluation of Tamsulosin in the Treatment of Ureteral Stones Completed NCT00151567 Phase 3 Tamsulosin;Placebo
19 Medical Expulsive Therapy for Ureter Stone Using Naftopidil Completed NCT01952314 Phase 3 Naftopidil 75mg;Placebo for Naftopidil;Standard treatment
20 Alfuzosin Hydrochloride to Promote Passage of Distal Ureteral Calculi Completed NCT00177086 Phase 3
21 Effectiveness of Silodosin in Medical Expulsive Therapy for Ureteral Pelvic Stone From 4 to 10 mm. Terminated NCT02090439 Phase 3 Silodosin
22 Use of Alfuzosin in Stone Treatment With ESWL Withdrawn NCT00388271 Phase 3 Alfuzosin (Xatral);standard treatment
23 Comparing Patients After ESWL Treated With Ureteral Stents Versus Expulsion Therapy With Tamsulosin Unknown status NCT00478998 Phase 2 Tamsulosin
24 Does Treatment With Alfuzosin Increase Success Rates of (SWL) Shock Wave Lithotripsy Unknown status NCT00409227 Phase 2 Alpha blocker-alfuzosin;placebo
25 Study of Silodosin to Facilitate Passage of Urinary Stones Completed NCT01144949 Phase 2 silodosin;placebo
26 A Dose-finding Study of Silodosin in Patients With Urinary Calculi Completed NCT01539265 Phase 2 silodosin;silodosin;placebo
27 Mirabegron as Medical Expulsive Therapy (MET) for Ureteral Stones and Ureteral Stent Pain Recruiting NCT02744430 Phase 2 Mirabegron
28 Feasibility Study of the Uriprene Stent Following Uncomplicated Ureteroscopy Completed NCT02032316 Phase 1
29 Sterile Water Injections for Relieving Ureterolithiasis Pain Unknown status NCT01412840 Not Applicable
30 Silent Ureteral Stone: Impact on Renal Function and Kidney Anatomy Unknown status NCT01884870 Not Applicable
31 US-Non Contrast Computed Tomography Real-time Fusion for Urinary Stones Follow up Unknown status NCT02539004
32 Comparative Treatment Study in Patients With Lower Ureteral Stones Unknown status NCT00397397
33 Impact of Low Dose Fluoroscopy in Ureteroscopy Unknown status NCT02704949 Not Applicable
34 Shockwave Lithotripsy (SWL) Under Selective, General Anesthesia. Unknown status NCT01008267
35 Prospective Comparison Between Different Laser Settings for Ureteral \ Kidney Stones Treatment During Ureteroscopy Unknown status NCT02279927 Not Applicable
36 Intraureteral Lidocaine for Post-Ureteroscopy Pain Unknown status NCT01450566 Not Applicable Lidocaine;Saline
37 Delayed or Direct Ureteroscopy in the Treatment of Pediatric Calcular Anuria Unknown status NCT02139059 Not Applicable
38 ESWL vs URS in Management of Upper Third Ureteric Calculi Completed NCT03559738
39 Comparing Uretersocopy With Versus Without Use of Guide-wire in Treatment of Ureteral Stone Completed NCT03726502 Not Applicable
40 The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients Completed NCT00600405 Not Applicable tamsulosin;Standard therapy with ibuprofen and oxycodone.
41 Study on 'The Use of Non-contrast Helical Computerized Tomogram in Predicting Treatment Outcomes of Upper Ureteric Stone by Extracorporeal Shock Wave Lithotripsy Using the Sonolith 4000+ Lithotripter' Completed NCT00517205
42 Medical Expulsive Therapy of Single Distal Ureteral Stones Completed NCT00831701 Not Applicable Tamsulosin;Placebo
43 The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients Completed NCT00448123 Not Applicable Tamsulosin;Placebo
44 Management of Ureteral Calculi Using Ultrasound Guidance: A Radiation Free Approach Completed NCT01792765 Not Applicable
45 Effect of Tamsulosin on Stone Expulsion and Pain Resolution in ED Patients With Ureterolithiasis Completed NCT00762424 Not Applicable Flowmax;placebo
46 Is Prophylactic Antibiotics Necessary In Otherwise Healthy Adult Patients Undergoing Ureteroscopic Procedures for Ureteral Stones? Completed NCT02635490
47 Use of the PercSys MicroStent Device to Alleviate Ureteral Stone Symptoms and Hydronephrosis Completed NCT01637519
48 Ureteral Stents Versus Percutaneous Nephrostomy for Initial Urinary Drainage Completed NCT02055430 Not Applicable
49 Role of Flexible Cystoscopy in Laparoscopic Stone Surgery Completed NCT01277198
50 The Usefulness of Flexible Cystoscopy for Preventing Double-J Stent Malposition After Laparoscopic Ureterolithotomy Completed NCT03150446 Not Applicable

Search NIH Clinical Center for Ureterolithiasis

Cochrane evidence based reviews: ureterolithiasis

Genetic Tests for Ureterolithiasis

Anatomical Context for Ureterolithiasis

MalaCards organs/tissues related to Ureterolithiasis:

41
Kidney, Adrenal Gland, Bone

Publications for Ureterolithiasis

Articles related to Ureterolithiasis:

(show top 50) (show all 99)
# Title Authors Year
1
Bilateral ureterolithiasis: A true positive and false negative PoCUS exam in a patient with renal colic. ( 29606152 )
2018
2
Perinephric fat stranding is associated with elevated creatinine among patients with acutely obstructing ureterolithiasis. ( 29943669 )
2018
3
Acute synchronous appendicitis and obstructing ureterolithiasis. ( 30108673 )
2018
4
CONTACT ULTRASOUND LITHOTRIPSY DURING URETEROLITHIASIS THERAPY. AN ANALYSIS OF LATE POSTOPERATIVE COMPLICATIONS. ( 30358535 )
2018
5
Narcotic Pain Control for Ureterolithiasis Is Associated With Unnecessary Repeat Imaging in the Emergency Department. ( 30358635 )
2018
6
Epidemiological and imaging features that can affect the detection of ureterolithiasis on ultrasound. ( 30369654 )
2018
7
Spontaneous proximal ureteric rupture secondary to ureterolithiasis. ( 28069871 )
2017
8
Ureterolithiasis: Management in an environment with limited facilities. ( 28513524 )
2017
9
Comparison between double-pigtail ureteral stents and ureteral bypass devices for treatment of ureterolithiasis in cats. ( 28763282 )
2017
10
Comparison of prone vs. supineA unenhanced CT imaging in patients with clinically suspected ureterolithiasis. ( 27670877 )
2016
11
Medical Expulsive Therapy for Ureterolithiasis: The EAU Recommendations in 2016. ( 27506951 )
2016
12
Beyond ureterolithiasis: gamut of abnormalities affecting the ureter. ( 27317212 )
2016
13
Is hydronephrosis on ultrasound predictive of ureterolithiasis in patients with renal colic? ( 27154825 )
2016
14
Management of Ureterolithiasis in a Patient with Crossed Unfused Renal Ectopia. ( 27403369 )
2016
15
Clinical relevance of seasonal changes in the prevalence of ureterolithiasis in the diagnosis of renal colic. ( 27314408 )
2016
16
Long-term Adverse Effects of Extracorporeal Shock-wave Lithotripsy for Nephrolithiasis and Ureterolithiasis: A Systematic Review. ( 25917723 )
2015
17
The use of alpha-1 adrenergic blockers in children with distal ureterolithiasis: a systematic review and meta-analysis. ( 26717117 )
2015
18
Tamsulosin for treatment of unilateral distal ureterolithiasis: a systematic review and meta-analysis. ( 24852587 )
2014
19
Indwelling double pigtail ureteral stent combined or not with surgery for feline ureterolithiasis: complications and outcome in 15 cases. ( 24305471 )
2013
20
Pyeloduodenal fistula due to proximal ureterolithiasis and its successful conservative management. ( 24051966 )
2013
21
Terpene compound drug as medical expulsive therapy for ureterolithiasis: a meta-analysis. ( 23503876 )
2013
22
Re: terpene compound drug as medical expulsive therapy for ureterolithiasis: a meta-analysis. ( 23421365 )
2013
23
Tamsulosin for treatment of unilateral distal ureterolithiasis: a systematic review and meta-analysis. ( 23870675 )
2013
24
Anuria and abdominal pain induced by ceftriaxone-associated ureterolithiasis in adults. ( 23180444 )
2013
25
Bladder bulge: unifying old and new sonographic bladder wall abnormalities in ureterolithiasis. ( 23358632 )
2012
26
Bedside renal ultrasound in the evaluation of suspected ureterolithiasis. ( 21185667 )
2012
27
Unusual presentation of bilateral ureteroceles with ureterolithiasis in a patient after robotic prostatectomy. ( 22546412 )
2012
28
Synchronous obstructive ureterolithiasis and acute appendicitis. ( 24960802 )
2012
29
Endoscopic holmium laser treatment for ureterolithiasis. ( 24578918 )
2012
30
Health related quality of life in ureteral stone patients: post-ureterolithiasis. ( 21461963 )
2011
31
Ureterolithiasis in children. ( 21585171 )
2011
32
The effect of alpha-blockade in emergency department patients with ureterolithiasis. ( 19217243 )
2010
33
The sensitivity of transabdominal ultrasound in the diagnosis of ureterolithiasis. ( 21203595 )
2010
34
A case of calcified ureteritis cystica: an indiscernible condition from ureterolithiasis. ( 19655701 )
2009
35
Acute onset of renal colic from bilateral ureterolithiasis: a case report. ( 19829794 )
2009
36
Type IV ureteral triplication associated with ipsilateral ureterocele with ureterolithiasis and contralateral duplication with an ectopic ureteral orifice. ( 19138195 )
2008
37
Conventional and reduced radiation dose of 16-MDCT for detection of nephrolithiasis and ureterolithiasis. ( 18094305 )
2008
38
Usefulness of urinalysis in following patients with distal ureterolithiasis. ( 18578655 )
2008
39
The utility of unenhanced helical CT in assessing the frequency of ureterolithiasis in Saudi patients. ( 18246228 )
2008
40
Cost-effectiveness analysis (CEA) of intravenous urography (IVU) and unenhanced multidetector computed tomography (MDCT) for initial investigation of suspected acute ureterolithiasis. ( 18300151 )
2008
41
Comparison between ultrasound and noncontrast helical computed tomography for identification of acute ureterolithiasis in a teaching hospital setting. ( 17625708 )
2007
42
Ureteroscopical treatment of ureterolithiasis in childhood. Our experience. ( 16752883 )
2006
43
Electro-acupuncture treatment for the upper segment ureterolithiasis under B-ultrasonography. ( 15889513 )
2005
44
Medical-expulsive therapy for distal ureterolithiasis: randomized prospective study on role of corticosteroids used in combination with tamsulosin-simplified treatment regimen and health-related quality of life. ( 16230122 )
2005
45
Ureterolithiasis after Cohen re-implantation--case report. ( 15070415 )
2004
46
Diagnostic value of attenuation measurements of the kidney on unenhanced helical CT of obstructive ureterolithiasis. ( 15100127 )
2004
47
Unenhanced helical CT of ureterolithiasis: incidence of secondary urinary tract findings. ( 15058632 )
2004
48
Unenhanced helical CT scan for ureterolithiasis. ( 15321049 )
2004
49
Pneumatic lithotripsy for ureterolithiasis: clinical analysis of 512 cases. ( 12865242 )
2003
50
Helical CT for nephrolithiasis and ureterolithiasis: comparison of conventional and reduced radiation-dose techniques. ( 14526095 )
2003

Variations for Ureterolithiasis

Expression for Ureterolithiasis

Search GEO for disease gene expression data for Ureterolithiasis.

Pathways for Ureterolithiasis

GO Terms for Ureterolithiasis

Cellular components related to Ureterolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendritic spine GO:0043197 8.62 AKAP5 APBB1

Biological processes related to Ureterolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 8.62 ADRA1A TRPV1

Molecular functions related to Ureterolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 8.62 AKAP5 TRPV1

Sources for Ureterolithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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