MCID: URT032
MIFTS: 31

Urethra Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Urethra Adenocarcinoma

MalaCards integrated aliases for Urethra Adenocarcinoma:

Name: Urethra Adenocarcinoma 12 15
Adenocarcinoma of the Urethra 12
Urethral Adenocarcinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4910
NCIt 51 C6167
UMLS 74 C1336885

Summaries for Urethra Adenocarcinoma

Disease Ontology : 12 An urethra cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Urethra Adenocarcinoma, also known as adenocarcinoma of the urethra, is related to urethra clear cell adenocarcinoma and clear cell adenocarcinoma. An important gene associated with Urethra Adenocarcinoma is FNDC3B (Fibronectin Type III Domain Containing 3B), and among its related pathways/superpathways are Pathways in cancer and Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex. The drugs Ipilimumab and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include lymph node, kidney and testis, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Urethra Adenocarcinoma

Graphical network of the top 20 diseases related to Urethra Adenocarcinoma:



Diseases related to Urethra Adenocarcinoma

Symptoms & Phenotypes for Urethra Adenocarcinoma

MGI Mouse Phenotypes related to Urethra Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 ALK AMACR APP ARID2 ATM FNDC3B
2 mortality/aging MP:0010768 9.23 ALK AMACR APP ARID2 ATM FNDC3B

Drugs & Therapeutics for Urethra Adenocarcinoma

Drugs for Urethra Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ipilimumab Approved Phase 2 477202-00-9
2
nivolumab Approved Phase 2 946414-94-4
3 Immunoglobulins Phase 2
4 Antibodies Phase 2
5 Antineoplastic Agents, Immunological Phase 2
6 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Urethra Adenocarcinoma

Genetic Tests for Urethra Adenocarcinoma

Anatomical Context for Urethra Adenocarcinoma

MalaCards organs/tissues related to Urethra Adenocarcinoma:

42
Lymph Node, Kidney, Testis, Appendix

Publications for Urethra Adenocarcinoma

Articles related to Urethra Adenocarcinoma:

(show all 22)
# Title Authors Year
1
Clear cell adenocarcinoma of the urethra with inguinal lymph node metastases: A rare case report and review of literature. ( 29516944 )
2018
2
Female Urethra Adenocarcinoma. ( 29113768 )
2018
3
Clear Cell Adenocarcinoma of the Urethra in Women: Distinctive MRI Findings for Differentiation From Nonadenocarcinoma and Non-Clear Cell Adenocarcinoma of the Urethra. ( 28140610 )
2017
4
Clear cell adenocarcinoma of the urethra: 18F-FDG PET/CT imaging. ( 25140553 )
2015
5
Clear cell adenocarcinoma of the urethra: review of the literature. ( 25685552 )
2015
6
Adenocarcinoma of the urethra with mucinous features. ( 26029002 )
2015
7
Primary Adenocarcinoma of the Urethra: A Case Report and Review of the Literature. ( 27579397 )
2015
8
Primary enteric-type mucinous adenocarcinoma of the urethra in a patient with ulcerative colitis. ( 25216440 )
2014
9
Female urethra adenocarcinoma: report of two cases and bibliographic review. ( 25306993 )
2014
10
Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems. ( 23307189 )
2013
11
Metastatic clear cell adenocarcinoma of the urethra in a male patient: report of a case. ( 22056213 )
2012
12
Cytologic findings of clear cell adenocarcinoma of the urethra: a case report. ( 23110004 )
2012
13
Primary adenocarcinoma of the urethra with metastasis to the glans penis: successful treatment with chemotherapy and radiation therapy. ( 9730476 )
1998
14
Clear cell adenocarcinoma of the urethra: a clinicopathologic analysis of 19 cases. ( 8733766 )
1996
15
Colloid adenocarcinoma of the urethra associated with mucosal in situ carcinoma. ( 1326256 )
1992
16
Clear cell adenocarcinoma of the urethra: evidence for origin within paraurethral ducts. ( 2294240 )
1990
17
Adenocarcinoma of the urethra in women. A clinicopathologic study. ( 3038294 )
1987
18
Clear cell adenocarcinoma of the urethra. ( 6700000 )
1984
19
Clear cell adenocarcinoma of the urethra. A case report. ( 7323759 )
1981
20
Mesonephric adenocarcinoma of the urethra in a woman: report of a case. ( 568184 )
1978
21
Adenocarcinoma of the urethra during pregnancy: report of a case. ( 559986 )
1977
22
Mucinous adenocarcinoma of the urethra: report of a case associated with urethritis glandularis. ( 13737402 )
1961

Variations for Urethra Adenocarcinoma

Expression for Urethra Adenocarcinoma

Search GEO for disease gene expression data for Urethra Adenocarcinoma.

Pathways for Urethra Adenocarcinoma

Pathways related to Urethra Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.98 ALK KLK3 PAX8 SMAD4
2 9.97 ATM SMAD4

GO Terms for Urethra Adenocarcinoma

Biological processes related to Urethra Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.33 ALK ATM PAX8
2 branching involved in ureteric bud morphogenesis GO:0001658 8.96 PAX8 SMAD4
3 kidney development GO:0001822 8.8 PAX8 SMAD4 UPK3A

Sources for Urethra Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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