MCID: URT033
MIFTS: 23

Urethra Cancer

Categories: Cancer diseases

Aliases & Classifications for Urethra Cancer

MalaCards integrated aliases for Urethra Cancer:

Name: Urethra Cancer 12 15
Malignant Tumour of Urethra 12
Malignant Urethral Neoplasm 12
Cancer of Urethra 12
Urethral Ca 12

Classifications:



External Ids:

Disease Ontology 12 DOID:734
ICD9CM 34 189.3
MeSH 44 D014523
NCIt 50 C7507 C9106
SNOMED-CT 67 363459007 94123008
ICD10 32 C68.0
UMLS 70 C0153620 C0700101

Summaries for Urethra Cancer

Disease Ontology : 12 An urinary tract cancer that derives from the tissues of the urethra.

MalaCards based summary : Urethra Cancer, also known as malignant tumour of urethra, is related to urethra adenocarcinoma and posterior urethra cancer. An important gene associated with Urethra Cancer is ANKRD28 (Ankyrin Repeat Domain 28). The drugs Cisplatin and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include prostate and kidney.

Related Diseases for Urethra Cancer

Diseases in the Urethra Cancer family:

Posterior Urethra Cancer Anterior Urethra Cancer

Diseases related to Urethra Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 urethra adenocarcinoma 30.0 KLK3 FNDC3B ARID2 ANKRD28 AMACR
2 posterior urethra cancer 11.1
3 anterior urethra cancer 11.1
4 urethra squamous cell carcinoma 11.0
5 urethra transitional cell carcinoma 11.0
6 radiation cystitis 10.0 UPK3A KLK3
7 transitional cell carcinoma 9.9 UPK3A KLK3
8 pyuria 9.9 UPK3A KLK3
9 bladder sarcoma 9.9 UPK3A KLK3
10 neurogenic bladder 9.8 UPK3A KLK3
11 glandular cystitis 9.8 UPK3A AMACR
12 urethral cancer 9.8
13 bladder clear cell adenocarcinoma 9.8 UPK3A AMACR
14 acute cystitis 9.8 UPK3A KLK3
15 clear cell adenocarcinoma 9.8 KLK3 AMACR
16 male urethral cancer 9.8 KLK3 AMACR
17 wolffian duct adenoma 9.8 KLK3 AMACR
18 female urethral cancer 9.8 KLK3 AMACR
19 prostatic acinar adenocarcinoma 9.8 KLK3 AMACR
20 nephrogenic adenoma 9.7 KLK3 AMACR
21 nephrogenic adenoma of the urethra 9.7 KLK3 AMACR
22 bladder lateral wall cancer 9.7 KLK3 AMACR
23 urinary tract obstruction 9.7 UPK3A KLK3
24 urethral benign neoplasm 9.7 KLK3 AMACR
25 prostate transitional cell carcinoma 9.7 KLK3 AMACR
26 seminal vesicle adenocarcinoma 9.7 KLK3 AMACR
27 urethral syndrome 9.6 KLK3 AMACR
28 urethral diverticulum 9.5 UPK3A KLK3 AMACR
29 bladder adenocarcinoma 9.5 UPK3A KLK3 AMACR
30 suppression of tumorigenicity 12 9.4 KLK3 AMACR
31 urethra clear cell adenocarcinoma 8.8 UPK3A KLK3 FNDC3B ARID2 ANKRD28 AMACR

Graphical network of the top 20 diseases related to Urethra Cancer:



Diseases related to Urethra Cancer

Symptoms & Phenotypes for Urethra Cancer

Drugs & Therapeutics for Urethra Cancer

Drugs for Urethra Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 1, Phase 2 15663-27-1 84093 441203 2767
2
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
3 Anti-Infective Agents Phase 1, Phase 2
4 Immunosuppressive Agents Phase 1, Phase 2
5 Antiviral Agents Phase 1, Phase 2
6 Immunologic Factors Phase 1, Phase 2
7 Interleukin-2 Phase 1, Phase 2
8 Antimetabolites Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase Ib/II Trial of ALT-801 in Combination With Cisplatin and Gemcitabine in Muscle Invasive or Metastatic Urothelial Cancer Unknown status NCT01326871 Phase 1, Phase 2 Cisplatin;Gemcitabine
2 Phase I/II Study of Avelumab in Combination With AXL Inhibitor AVB-S6-500 in Patients With Advanced Urothelial Carcinoma Recruiting NCT04004442 Phase 2 Avelumab;AVB-S6-500

Search NIH Clinical Center for Urethra Cancer

Genetic Tests for Urethra Cancer

Anatomical Context for Urethra Cancer

MalaCards organs/tissues related to Urethra Cancer:

40
Prostate, Kidney

Publications for Urethra Cancer

Articles related to Urethra Cancer:

(show all 15)
# Title Authors PMID Year
1
Update on the Medical and Surgical Management of Urethral Condyloma. 61
33752995 2021
2
Primary Squamous Cell Carcinoma of the Male Proximal Urethra: Outcomes from a Single Centre. 61
30853605 2021
3
Condyloma Acuminata of the Urethra in a Male Renal Transplant Recipient: A Case Report. 61
30316397 2018
4
Treatment and Outcomes of Primary Urethra Cancer. 61
28537991 2018
5
Cancer Risk After Midurethral Sling Surgery Using Polypropylene Mesh. 61
29420401 2018
6
HPV type 45-positive condyloma acuminata of the bladder in a renal transplant recipient. 61
28100036 2017
7
[Extra peritoneal anterior pelvic exenteration with total urethrectomy and vaginectomy for bladder and urethra cancer - clinical case and review of literature]. 61
24505640 2013
8
Second malignancies after prostate brachytherapy: incidence of bladder and colorectal cancers in patients with 15 years of potential follow-up. 61
16887293 2006
9
Prostate cancer detected by uPM3: radical prostatectomy findings. 61
16528369 2006
10
[Ultrasonographic assessment of urethral condyloma acuminatum in men]. 61
15949386 2005
11
[Diagnosis and treatment of urethral condyloma acuminatum in male patients]. 61
12479023 2002
12
Proximity of prostate cancer to the urethra: implications for minimally invasive ablative therapies. 61
11068288 2000
13
Kidney cancer mortality in The Netherlands, 1950-94: prediction of a decreasing trend. 61
10764244 1999
14
[Transitional cell carcinoma of the urethra in patients after cystectomy for bladder carcinoma]. 61
1492273 1992
15
[Carcinoma of the urethra in patients having undergone cystectomy for neoplasm of the bladder]. 61
2529636 1989

Variations for Urethra Cancer

Expression for Urethra Cancer

Search GEO for disease gene expression data for Urethra Cancer.

Pathways for Urethra Cancer

GO Terms for Urethra Cancer

Sources for Urethra Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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