MCID: URT024
MIFTS: 31

Urethra Clear Cell Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Urethra Clear Cell Adenocarcinoma

MalaCards integrated aliases for Urethra Clear Cell Adenocarcinoma:

Name: Urethra Clear Cell Adenocarcinoma 12 15
Clear Cell Adenocarcinoma of the Urethra 12
Urethral Clear Cell Adenocarcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5307
NCIt 49 C6172
UMLS 71 C1336886

Summaries for Urethra Clear Cell Adenocarcinoma

Disease Ontology : 12 A clear cell adenocarcinoma that is located in the urethra.

MalaCards based summary : Urethra Clear Cell Adenocarcinoma, also known as clear cell adenocarcinoma of the urethra, is related to nephrogenic adenoma and urethral diverticulum. An important gene associated with Urethra Clear Cell Adenocarcinoma is ANKRD28 (Ankyrin Repeat Domain 28), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include urethra, breast and lung, and related phenotypes are cellular and renal/urinary system

Related Diseases for Urethra Clear Cell Adenocarcinoma

Diseases related to Urethra Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 329)
# Related Disease Score Top Affiliating Genes
1 nephrogenic adenoma 30.7 PAX8 PAX2 KRT7 KLK3 AMACR
2 urethral diverticulum 30.6 UPK3A PAX8 KRT7 KLK3 AMACR
3 adenoma 30.4 TP53 SMAD4 KRT7 CDKN2A
4 adenocarcinoma 29.9 TP53 SMAD4 KRT7 KRT20 CDKN2A ALK
5 clear cell adenocarcinoma 29.2 TP53 SMAD4 PAX8 PAX2 KRT7 KRT20
6 male urethral cancer 10.6 KLK3 AMACR
7 transitional papilloma 10.5 UPK3A KRT7
8 ovarian mesodermal adenosarcoma 10.5 PAX8 KRT7
9 renal pelvis adenocarcinoma 10.5 PAX8 KRT7
10 cervical basaloid squamous cell carcinoma 10.5 KRT7 CDKN2A
11 endometrial transitional cell carcinoma 10.5 KRT7 CDKN2A
12 renal pelvis transitional cell carcinoma 10.5 UPK3A KRT7
13 anal canal paget's disease 10.5 KRT7 CDKN2A
14 adenosquamous prostate carcinoma 10.5 KLK3 AMACR
15 anus basaloid carcinoma 10.5 KRT7 CDKN2A
16 prostate lymphoma 10.5 KLK3 AMACR
17 cervical adenoid cystic carcinoma 10.5 KRT7 CDKN2A
18 vulval paget's disease 10.5 UPK3A KRT7
19 clear cell papillary renal cell carcinoma 10.5 KRT7 AMACR
20 chromophil adenoma of the kidney 10.4 KRT7 AMACR
21 mucinous intrahepatic cholangiocarcinoma 10.4 SMAD4 KRT7
22 submandibular gland cancer 10.4 KRT7 KLK3
23 thymus basaloid carcinoma 10.4 PAX8 KRT5
24 ceruminoma 10.4 KRT7 KRT5
25 ureter adenocarcinoma 10.4 KRT7 KRT5
26 benign breast adenomyoepithelioma 10.4 KRT7 KRT5
27 breast adenomyoepithelioma 10.4 KRT7 KRT5
28 subareolar duct papillomatosis 10.4 KRT7 KRT5
29 bone leiomyosarcoma 10.4 KRT7 KRT5
30 nipple neoplasm 10.4 KRT7 KRT5
31 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
32 radiation cystitis 10.4 UPK3A KLK3
33 ceruminous adenocarcinoma 10.4 KRT7 KRT5
34 external ear carcinoma 10.4 KRT7 KRT5
35 ureteral benign neoplasm 10.4 UPK3A KRT7
36 prostatic acinar adenocarcinoma 10.4 PAX8 KLK3 AMACR
37 gastric squamous cell carcinoma 10.4 KRT7 KRT5
38 middle ear adenoma 10.4 KRT7 KRT5
39 breast myoepithelial neoplasm 10.4 KRT7 KRT5
40 mediastinum liposarcoma 10.4 CDKN2A ATM
41 pancreatic foamy gland adenocarcinoma 10.4 TP53 KRT7
42 ureterocele 10.4 PAX8 PAX2
43 eccrine papillary adenocarcinoma 10.3 KRT7 KRT5
44 sensory organ benign neoplasm 10.3 KRT7 KRT5
45 inflammatory liposarcoma 10.3 CDKN2A ALK
46 urethral villous adenoma 10.3 KRT7 KRT20
47 bile duct mucoepidermoid carcinoma 10.3 KRT7 KRT5
48 breast metaplastic carcinoma 10.3 KRT7 KRT5
49 breast mucinous carcinoma 10.3 KRT7 KRT5
50 pancreatic serous cystadenocarcinoma 10.3 KRT7 KRT20

Graphical network of the top 20 diseases related to Urethra Clear Cell Adenocarcinoma:



Diseases related to Urethra Clear Cell Adenocarcinoma

Symptoms & Phenotypes for Urethra Clear Cell Adenocarcinoma

MGI Mouse Phenotypes related to Urethra Clear Cell Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 ARID2 ATM CDKN2A FNDC3B FUT4 KRT7
2 renal/urinary system MP:0005367 9.17 KRT7 PAX2 PAX8 SMAD4 THBD TP53

Drugs & Therapeutics for Urethra Clear Cell Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Urethra Clear Cell Adenocarcinoma

Genetic Tests for Urethra Clear Cell Adenocarcinoma

Anatomical Context for Urethra Clear Cell Adenocarcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Urethra Clear Cell Adenocarcinoma:

19
Urethra

MalaCards organs/tissues related to Urethra Clear Cell Adenocarcinoma:

40
Breast, Lung, Thymus, Kidney, Prostate, Colon, Liver

Publications for Urethra Clear Cell Adenocarcinoma

Articles related to Urethra Clear Cell Adenocarcinoma:

# Title Authors PMID Year
1
[Two Cases of Urethral Clear Cell Adenocarcinoma with Suspected Recurrence of Uterine Cancer]. 61
28889719 2017
2
Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. 61
24389164 2014
3
Clear cell adenocarcinoma of the male urethra. 61
12757608 2003
4
Clear cell adenocarcinoma of the urethra: a clinicopathologic analysis of 19 cases. 61
8733766 1996
5
MR and CT appearance of urethral clear cell adenocarcinoma in a woman. 61
8537508 1995
6
Clear cell adenocarcinoma of the female urethra. A case report. 61
3389150 1988

Variations for Urethra Clear Cell Adenocarcinoma

Expression for Urethra Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Urethra Clear Cell Adenocarcinoma.

Pathways for Urethra Clear Cell Adenocarcinoma

GO Terms for Urethra Clear Cell Adenocarcinoma

Biological processes related to Urethra Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.87 TP53 PAX8 ATM ALK
2 branching involved in ureteric bud morphogenesis GO:0001658 9.67 SMAD4 PAX8 PAX2
3 mesonephros development GO:0001823 9.56 PAX8 PAX2
4 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.55 PAX8 PAX2
5 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.54 PAX8 PAX2
6 pronephros development GO:0048793 9.52 PAX8 PAX2
7 metanephric epithelium development GO:0072207 9.51 PAX8 PAX2
8 metanephric nephron tubule formation GO:0072289 9.48 PAX8 PAX2
9 metanephric distal convoluted tubule development GO:0072221 9.46 PAX8 PAX2
10 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.43 PAX8 PAX2
11 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.4 PAX8 PAX2
12 positive regulation of metanephric DCT cell differentiation GO:2000594 9.37 PAX8 PAX2
13 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.32 PAX8 PAX2
14 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.26 PAX8 PAX2
15 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX8 PAX2
16 pronephric field specification GO:0039003 8.96 PAX8 PAX2
17 replicative senescence GO:0090399 8.8 TP53 CDKN2A ATM

Molecular functions related to Urethra Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 8.92 TP53 SMAD4 PAX8 PAX2

Sources for Urethra Clear Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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