MCID: URT018
MIFTS: 24

Urethra Transitional Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Urethra Transitional Cell Carcinoma

MalaCards integrated aliases for Urethra Transitional Cell Carcinoma:

Name: Urethra Transitional Cell Carcinoma 12 15
Urethral Transitional Cell Carcinoma 12
Urethral Urothelial Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4013
NCIt 49 C6166
UMLS 71 C0863015

Summaries for Urethra Transitional Cell Carcinoma

Disease Ontology : 12 An urethra cancer that is characterized by cancer cells forming in the renal pelvis and ureter.

MalaCards based summary : Urethra Transitional Cell Carcinoma, also known as urethral transitional cell carcinoma, is related to papillary transitional carcinoma and glandular cystitis. An important gene associated with Urethra Transitional Cell Carcinoma is UPK3A (Uroplakin 3A), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and Fluid shear stress and atherosclerosis. Related phenotypes are cardiovascular system and digestive/alimentary

Related Diseases for Urethra Transitional Cell Carcinoma

Diseases related to Urethra Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 papillary transitional carcinoma 10.3 UPK3A TP53
2 glandular cystitis 10.3 UPK3A TP53
3 urinary tract papillary transitional cell benign neoplasm 10.3 UPK3A TP53
4 bladder papillary transitional cell neoplasm 10.3 UPK3A TP53
5 bladder clear cell adenocarcinoma 10.3 UPK3A TP53
6 ovarian benign neoplasm 10.3 UPK3A TP53
7 urethra clear cell adenocarcinoma 10.3 UPK3A TP53
8 spinal cord oligodendroglioma 10.3 TP53 GFAP
9 gemistocytic astrocytoma 10.3 TP53 GFAP
10 gliofibroma 10.3 TP53 GFAP
11 cerebrovascular benign neoplasm 10.3 TP53 GFAP
12 cerebellum cancer 10.3 TP53 GFAP
13 transitional cell carcinoma 10.3
14 central nervous system primitive neuroectodermal neoplasm 10.2 TP53 GFAP
15 mixed glioma 10.2 TP53 GFAP
16 chordoid glioma 10.2 TP53 GFAP
17 sweat gland neoplasm 10.2 TP53 GFAP
18 cerebral ventricle cancer 10.2 TP53 GFAP
19 pituitary carcinoma 10.2 TP53 GFAP
20 cerebrum cancer 10.2 TP53 GFAP
21 supratentorial cancer 10.2 TP53 GFAP
22 papilloma of choroid plexus 10.2 TP53 GFAP
23 focal cortical dysplasia, type ii 10.2 TP53 GFAP
24 pleomorphic xanthoastrocytoma 10.2 TP53 GFAP
25 pediatric angiosarcoma 10.2 TP53 PECAM1
26 gliomatosis cerebri 10.2 TP53 GFAP
27 myoepithelial carcinoma 10.2 TP53 GFAP
28 breast hemangioma 10.2 TP53 PECAM1
29 fibrillary astrocytoma 10.2 TP53 GFAP
30 breast sarcoma 10.2 TP53 PECAM1
31 middle ear adenocarcinoma 10.2 PECAM1 GFAP
32 choroid plexus cancer 10.1 TP53 GFAP
33 gallbladder adenocarcinoma 10.1 TP53 PROM1
34 cystic teratoma 10.1 TP53 GFAP
35 central nervous system benign neoplasm 10.1 TP53 GFAP
36 nervous system benign neoplasm 10.1 TP53 GFAP
37 connective tissue benign neoplasm 10.1 TP53 PECAM1
38 mesenchymal cell neoplasm 10.1 TP53 PECAM1
39 cardiovascular cancer 10.1 TP53 PECAM1
40 vascular cancer 10.1 TP53 PECAM1
41 capillary disease 10.1 PROM1 PECAM1
42 capillary hemangioma 10.1 PROM1 PECAM1
43 lichen disease 10.0 TP53 ICAM1
44 fasciitis 10.0 TP53 GFAP
45 bladder cancer 10.0
46 primitive neuroectodermal tumor of the cervix uteri 9.9 PTPRC GFAP
47 prostate neuroendocrine neoplasm 9.9 TP53 PTPRC
48 cerebellopontine angle primitive neuroectodermal 9.9 PTPRC GFAP
49 infratentorial cancer 9.9 TP53 PROM1 GFAP
50 keratopathy 9.9 TP53 ICAM1

Graphical network of the top 20 diseases related to Urethra Transitional Cell Carcinoma:



Diseases related to Urethra Transitional Cell Carcinoma

Symptoms & Phenotypes for Urethra Transitional Cell Carcinoma

MGI Mouse Phenotypes related to Urethra Transitional Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 GFAP ICAM1 PECAM1 PROM1 PTPRC TP53
2 digestive/alimentary MP:0005381 9.02 GFAP ICAM1 PECAM1 PTPRC TP53

Drugs & Therapeutics for Urethra Transitional Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Urethra Transitional Cell Carcinoma

Genetic Tests for Urethra Transitional Cell Carcinoma

Anatomical Context for Urethra Transitional Cell Carcinoma

Publications for Urethra Transitional Cell Carcinoma

Articles related to Urethra Transitional Cell Carcinoma:

# Title Authors PMID Year
1
The dog as an animal model for bladder and urethral urothelial carcinoma: Comparative epidemiology and histology. 61
30008848 2018
2
Muscle-invasive bladder and urethral cancer recurrence after surgical management of upper tract urothelial carcinoma: A review of 305 patients. 61
29733795 2018
3
Management of the male urethra after cystectomy. 61
20674702 2010
4
Pathological guidelines for orthotopic urinary diversion in women with bladder cancer: a review of the literature. 61
17631333 2007

Variations for Urethra Transitional Cell Carcinoma

Expression for Urethra Transitional Cell Carcinoma

Search GEO for disease gene expression data for Urethra Transitional Cell Carcinoma.

Pathways for Urethra Transitional Cell Carcinoma

Pathways related to Urethra Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.5 PTPRC PECAM1 ICAM1
2 11.27 TP53 PECAM1 ICAM1
3 10.96 PECAM1 ICAM1
4 10.88 TP53 ICAM1 GFAP

GO Terms for Urethra Transitional Cell Carcinoma

Cellular components related to Urethra Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.86 UPK3A TP53 PTPRC PROM1 PECAM1 ICAM1
2 extracellular exosome GO:0070062 9.43 UPK3A PTPRC PROM1 PECAM1 ICAM1 ANXA5
3 membrane raft GO:0045121 9.33 PTPRC PECAM1 ICAM1
4 external side of plasma membrane GO:0009897 8.92 PTPRC PECAM1 ICAM1 ANXA5

Biological processes related to Urethra Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.58 PECAM1 ICAM1 GFAP
2 response to amino acid GO:0043200 9.43 TP53 ICAM1
3 cell aging GO:0007569 9.37 TP53 ICAM1
4 response to gamma radiation GO:0010332 9.32 TP53 PTPRC
5 establishment of endothelial barrier GO:0061028 9.26 PECAM1 ICAM1
6 bone marrow development GO:0048539 9.16 TP53 PTPRC
7 leukocyte cell-cell adhesion GO:0007159 9.13 PTPRC PECAM1 ICAM1
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 8.92 TP53 PTPRC PECAM1 ICAM1

Molecular functions related to Urethra Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 8.62 TP53 ANXA5

Sources for Urethra Transitional Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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