MCID: URT018
MIFTS: 16

Urethra Transitional Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Urethra Transitional Cell Carcinoma

MalaCards integrated aliases for Urethra Transitional Cell Carcinoma:

Name: Urethra Transitional Cell Carcinoma 12
Urethral Transitional Cell Carcinoma 12
Urethral Urothelial Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4013
NCIt 50 C6166
UMLS 73 C0863015

Summaries for Urethra Transitional Cell Carcinoma

Disease Ontology : 12 An urethra cancer that is characterized by cancer cells forming in the renal pelvis and ureter.

MalaCards based summary : Urethra Transitional Cell Carcinoma, also known as urethral transitional cell carcinoma, is related to bladder cancer and urethritis. The drugs Gemcitabine and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include prostate and kidney.

Related Diseases for Urethra Transitional Cell Carcinoma

Diseases related to Urethra Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 bladder cancer 9.8
2 urethritis 9.8
3 transitional cell carcinoma 9.8

Symptoms & Phenotypes for Urethra Transitional Cell Carcinoma

Drugs & Therapeutics for Urethra Transitional Cell Carcinoma

Drugs for Urethra Transitional Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 2,Phase 1 95058-81-4 60750
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3 Antibodies Phase 2,Phase 1
4 Antibodies, Monoclonal Phase 2,Phase 1
5 Immunoglobulins Phase 2,Phase 1
6 Anti-Infective Agents Phase 2,Phase 1
7 Antimetabolites Phase 2,Phase 1
8 Antimetabolites, Antineoplastic Phase 2,Phase 1
9 Antiviral Agents Phase 2,Phase 1
10 Immunosuppressive Agents Phase 2,Phase 1
11
nivolumab Approved Phase 1 946414-94-4
12
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
13
Pembrolizumab Approved Phase 1 1374853-91-4
14 Antimitotic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Atezolizumab With or Without Eribulin Mesylate in Treating Patients With Recurrent Locally Advanced or Metastatic Urothelial Cancer Recruiting NCT03237780 Phase 2 Atezolizumab;Eribulin Mesylate
2 Gemcitabine Hydrochloride and Eribulin Mesylate in Treating Patients With Bladder Cancer That is Advanced or Cannot Be Removed by Surgery Active, not recruiting NCT02178241 Phase 2 Eribulin Mesylate;Gemcitabine Hydrochloride
3 Eribulin Mesylate in Treating Patients With Locally Advanced or Metastatic Cancer of the Urothelium and Kidney Dysfunction Active, not recruiting NCT00365157 Phase 1, Phase 2 Eribulin Mesylate
4 Atezolizumab and CYT107 in Treating Participants With Locally Advanced, Inoperable, or Metastatic Urothelial Carcinoma Not yet recruiting NCT03513952 Phase 2 Atezolizumab
5 Cabozantinib-s-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors Recruiting NCT02496208 Phase 1 Cabozantinib S-malate
6 Pembrolizumab and Docetaxel or Gemcitabine Hydrochloride in Treating Patients Urothelial Cancer Recruiting NCT02437370 Phase 1 Pembrolizumab;Docetaxel;Gemcitabine Hydrochloride
7 Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate Not yet recruiting NCT03582475 Phase 1 Carboplatin;Cisplatin;Docetaxel;Etoposide

Search NIH Clinical Center for Urethra Transitional Cell Carcinoma

Genetic Tests for Urethra Transitional Cell Carcinoma

Anatomical Context for Urethra Transitional Cell Carcinoma

MalaCards organs/tissues related to Urethra Transitional Cell Carcinoma:

41
Prostate, Kidney

Publications for Urethra Transitional Cell Carcinoma

Articles related to Urethra Transitional Cell Carcinoma:

# Title Authors Year
1
The management of urethral transitional cell carcinoma after radical cystectomy for invasive bladder cancer. ( 15371837 )
2004

Variations for Urethra Transitional Cell Carcinoma

Cosmic variations for Urethra Transitional Cell Carcinoma:

9
(show all 27)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10724 TP53 urinary tract,urethra,carcinoma,transitional cell carcinoma c.839G>C p.R280T 17:7673781-7673781 10
2 COSM10704 TP53 urinary tract,urethra,carcinoma,transitional cell carcinoma c.844C>T p.R282W 17:7673776-7673776 10
3 COSM6906866 PBRM1 urinary tract,urethra,carcinoma,transitional cell carcinoma c.1619G>A p.R540K 3:52617461-52617461 10
4 COSM6906863 PBRM1 urinary tract,urethra,carcinoma,transitional cell carcinoma c.1669G>A p.D557N 3:52617411-52617411 10
5 COSM6911013 NOTCH3 urinary tract,urethra,carcinoma,transitional cell carcinoma c.1606+1G>C p.? 19:15187880-15187880 10
6 COSM6906861 NOTCH2 urinary tract,urethra,carcinoma,transitional cell carcinoma c.4428C>G p.I1476M 1:119925388-119925388 10
7 COSM124736 NFE2L2 urinary tract,urethra,carcinoma,transitional cell carcinoma c.85G>C p.D29H 2:177234232-177234232 10
8 COSM6906860 MTOR urinary tract,urethra,carcinoma,transitional cell carcinoma c.6571G>T p.D2191Y 1:11124589-11124589 10
9 COSM6954768 KMT2D urinary tract,urethra,carcinoma,transitional cell carcinoma c.9088G>A p.E3030K 12:49037458-49037458 10
10 COSM221070 KMT2D urinary tract,urethra,carcinoma,transitional cell carcinoma c.7994C>G p.S2665* 12:49038552-49038552 10
11 COSM6906872 KMT2C urinary tract,urethra,carcinoma,transitional cell carcinoma c.6925C>T p.Q2309* 7:152180935-152180935 10
12 COSM6911007 KMT2C urinary tract,urethra,carcinoma,transitional cell carcinoma c.13816G>C p.D4606H 7:152148111-152148111 10
13 COSM6911008 ETV6 urinary tract,urethra,carcinoma,transitional cell carcinoma c.410G>T p.G137V 12:11853508-11853508 10
14 COSM6906869 ESR1 urinary tract,urethra,carcinoma,transitional cell carcinoma c.640C>G p.Q214E 6:151842784-151842784 10
15 COSM48358 ERBB2 urinary tract,urethra,carcinoma,transitional cell carcinoma c.929C>T p.S310F 17:39711955-39711955 10
16 COSM6911012 DIS3 urinary tract,urethra,carcinoma,transitional cell carcinoma c.1756-1G>T p.? 13:72768913-72768913 10
17 COSM6906875 CREBBP urinary tract,urethra,carcinoma,transitional cell carcinoma c.3857G>A p.C1286Y 16:3745334-3745334 10
18 COSM6911011 BRCA2 urinary tract,urethra,carcinoma,transitional cell carcinoma c.8983G>A p.D2995N 13:32379779-32379779 10
19 COSM6906874 ATM urinary tract,urethra,carcinoma,transitional cell carcinoma c.8787-1G>C p.? 11:108354810-108354810 10
20 COSM1636702 urinary tract,urethra,carcinoma,transitional cell carcinoma c.844C>T p.R282W 17:7673776-7673776 10
21 COSM6911010 urinary tract,urethra,carcinoma,transitional cell carcinoma c.8983G>A p.D2995N 13:32379779-32379779 10
22 COSM6911006 urinary tract,urethra,carcinoma,transitional cell carcinoma c.13987G>C p.D4663H 7:152148111-152148111 10
23 COSM6911014 urinary tract,urethra,carcinoma,transitional cell carcinoma c.1606+1G>C p.? 19:15187880-15187880 10
24 COSM99925 urinary tract,urethra,carcinoma,transitional cell carcinoma c.844C>T p.R282W 17:7673776-7673776 10
25 COSM6954767 urinary tract,urethra,carcinoma,transitional cell carcinoma c.9898G>A p.E3300K 12:49037458-49037458 10
26 COSM221071 urinary tract,urethra,carcinoma,transitional cell carcinoma c.8804C>G p.S2935* 12:49038552-49038552 10
27 COSM3378339 urinary tract,urethra,carcinoma,transitional cell carcinoma c.844C>T p.R282W 17:7673776-7673776 10

Expression for Urethra Transitional Cell Carcinoma

Search GEO for disease gene expression data for Urethra Transitional Cell Carcinoma.

Pathways for Urethra Transitional Cell Carcinoma

GO Terms for Urethra Transitional Cell Carcinoma

Sources for Urethra Transitional Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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