MCID: URT018
MIFTS: 22

Urethra Transitional Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Urethra Transitional Cell Carcinoma

MalaCards integrated aliases for Urethra Transitional Cell Carcinoma:

Name: Urethra Transitional Cell Carcinoma 12 15
Urethral Transitional Cell Carcinoma 12
Urethral Urothelial Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4013
NCIt 49 C6166
UMLS 71 C0863015

Summaries for Urethra Transitional Cell Carcinoma

Disease Ontology : 12 An urethra cancer that is characterized by cancer cells forming in the renal pelvis and ureter.

MalaCards based summary : Urethra Transitional Cell Carcinoma, also known as urethral transitional cell carcinoma, is related to papillary transitional carcinoma and non-invasive bladder papillary urothelial neoplasm. An important gene associated with Urethra Transitional Cell Carcinoma is UPK3A (Uroplakin 3A), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and Fluid shear stress and atherosclerosis. Related phenotype is digestive/alimentary.

Related Diseases for Urethra Transitional Cell Carcinoma

Diseases related to Urethra Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 papillary transitional carcinoma 10.3 UPK3A TP53
2 non-invasive bladder papillary urothelial neoplasm 10.3 UPK3A TP53
3 glandular cystitis 10.3 UPK3A TP53
4 urinary tract papillary transitional cell benign neoplasm 10.3 UPK3A TP53
5 bladder papillary transitional cell neoplasm 10.3 UPK3A TP53
6 transitional cell carcinoma 10.3
7 invasive bladder transitional cell carcinoma 10.3 UPK3A TP53
8 bladder clear cell adenocarcinoma 10.3 UPK3A TP53
9 skin papilloma 10.3 TP53 HBZ
10 spinal cord oligodendroglioma 10.3 TP53 GFAP
11 t-cell adult acute lymphocytic leukemia 10.2 TP53 HBZ
12 gemistocytic astrocytoma 10.2 TP53 GFAP
13 cerebrovascular benign neoplasm 10.2 TP53 GFAP
14 cerebellum cancer 10.2 TP53 GFAP
15 cerebellar medulloblastoma 10.2 TP53 GFAP
16 central nervous system primitive neuroectodermal neoplasm 10.2 TP53 GFAP
17 mixed glioma 10.2 TP53 GFAP
18 chordoid glioma 10.2 TP53 GFAP
19 spinal cancer 10.2 TP53 GFAP
20 sweat gland benign neoplasm 10.2 TP53 GFAP
21 malignant ependymoma 10.2 TP53 GFAP
22 cerebrum cancer 10.2 TP53 GFAP
23 cerebral ventricle cancer 10.2 TP53 GFAP
24 supratentorial cancer 10.2 TP53 GFAP
25 focal cortical dysplasia, type ii 10.2 TP53 GFAP
26 papilloma of choroid plexus 10.2 TP53 GFAP
27 pediatric angiosarcoma 10.2 TP53 PECAM1
28 laryngeal benign neoplasm 10.2 TP53 PROM1
29 gliomatosis cerebri 10.2 TP53 GFAP
30 breast hemangioma 10.2 TP53 PECAM1
31 pleomorphic xanthoastrocytoma 10.2 TP53 GFAP
32 liver angiosarcoma 10.2 TP53 PECAM1
33 fibrillary astrocytoma 10.2 TP53 GFAP
34 myoepithelial carcinoma 10.2 TP53 GFAP
35 breast sarcoma 10.2 TP53 PECAM1
36 middle ear adenocarcinoma 10.1 PECAM1 GFAP
37 cystic teratoma 10.1 TP53 GFAP
38 vulva cancer 10.1 UPK3A TP53
39 choroid plexus cancer 10.1 TP53 GFAP
40 mesenchymal cell neoplasm 10.0 TP53 PECAM1
41 capillary hemangioma 10.0 PROM1 PECAM1
42 cardiovascular cancer 10.0 TP53 PECAM1
43 connective tissue benign neoplasm 10.0 TP53 PECAM1
44 capillary disease 10.0 PROM1 PECAM1
45 central nervous system benign neoplasm 10.0 TP53 GFAP
46 lichen disease 10.0 TP53 ICAM1
47 bladder cancer 10.0
48 multifocal osteogenic sarcoma 10.0 TP53 PTPRC
49 primitive neuroectodermal tumor of the cervix uteri 9.9 PTPRC GFAP
50 prostate neuroendocrine neoplasm 9.9 TP53 PTPRC

Graphical network of the top 20 diseases related to Urethra Transitional Cell Carcinoma:



Diseases related to Urethra Transitional Cell Carcinoma

Symptoms & Phenotypes for Urethra Transitional Cell Carcinoma

MGI Mouse Phenotypes related to Urethra Transitional Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 GFAP ICAM1 PECAM1 PTPRC TP53

Drugs & Therapeutics for Urethra Transitional Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Urethra Transitional Cell Carcinoma

Genetic Tests for Urethra Transitional Cell Carcinoma

Anatomical Context for Urethra Transitional Cell Carcinoma

Publications for Urethra Transitional Cell Carcinoma

Articles related to Urethra Transitional Cell Carcinoma:

# Title Authors PMID Year
1
The dog as an animal model for bladder and urethral urothelial carcinoma: Comparative epidemiology and histology. 61
30008848 2018
2
Muscle-invasive bladder and urethral cancer recurrence after surgical management of upper tract urothelial carcinoma: A review of 305 patients. 61
29733795 2018
3
Management of the male urethra after cystectomy. 61
20674702 2010
4
Pathological guidelines for orthotopic urinary diversion in women with bladder cancer: a review of the literature. 61
17631333 2007

Variations for Urethra Transitional Cell Carcinoma

Expression for Urethra Transitional Cell Carcinoma

Search GEO for disease gene expression data for Urethra Transitional Cell Carcinoma.

Pathways for Urethra Transitional Cell Carcinoma

Pathways related to Urethra Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.5 PTPRC PECAM1 ICAM1
2 11.27 TP53 PECAM1 ICAM1
3 10.96 PECAM1 ICAM1
4 10.88 TP53 ICAM1 GFAP

GO Terms for Urethra Transitional Cell Carcinoma

Cellular components related to Urethra Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.33 PTPRC PECAM1 ICAM1
2 external side of plasma membrane GO:0009897 9.26 PTPRC PECAM1 ICAM1 ANXA5
3 extracellular exosome GO:0070062 9.17 UPK3A PTPRC PROM1 PECAM1 ICAM1 HBZ

Biological processes related to Urethra Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.58 PECAM1 ICAM1 GFAP
2 cell aging GO:0007569 9.37 TP53 ICAM1
3 response to gamma radiation GO:0010332 9.32 TP53 PTPRC
4 establishment of endothelial barrier GO:0061028 9.26 PECAM1 ICAM1
5 bone marrow development GO:0048539 9.16 TP53 PTPRC
6 leukocyte cell-cell adhesion GO:0007159 9.13 PTPRC PECAM1 ICAM1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 8.92 TP53 PTPRC PECAM1 ICAM1

Sources for Urethra Transitional Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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