Urethral Cancer

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Urethral Cancer

MalaCards integrated aliases for Urethral Cancer:

Name: Urethral Cancer 52
Urethral Carcinoma 71


External Ids:

UMLS 71 C0700101

Summaries for Urethral Cancer

MalaCards based summary : Urethral Cancer, also known as urethral carcinoma, is related to male urethral cancer and female urethral cancer. The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include prostate, kidney and liver.

Wikipedia : 74 Urethral cancer is cancer originating from the urethra. Cancer in this location is rare, and the most... more...

Related Diseases for Urethral Cancer

Graphical network of the top 20 diseases related to Urethral Cancer:

Diseases related to Urethral Cancer

Symptoms & Phenotypes for Urethral Cancer

Drugs & Therapeutics for Urethral Cancer

Drugs for Urethral Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
4 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
5 Albumin-Bound Paclitaxel Phase 3
6 Cola Phase 3
7 Liver Extracts Phase 3
8 Narcotics Phase 3
9 Anesthetics Phase 3
10 Analgesics Phase 3
11 Analgesics, Opioid Phase 3
12 Anesthetics, General Phase 3
13 Central Nervous System Depressants Phase 3
14 Adjuvants, Anesthesia Phase 3
15 Anesthetics, Intravenous Phase 3
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
Ifosfamide Approved Phase 2 3778-73-2 3690
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
Pemetrexed Approved, Investigational Phase 2 150399-23-8, 137281-23-3 60843 446556
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177 70789204
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
Atezolizumab Approved, Investigational Phase 2 1380723-44-3
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
afatinib Approved Phase 2 439081-18-2, 850140-72-6 10184653
Fluorouracil Approved Phase 2 51-21-8 3385
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057
Rubitecan Investigational Phase 2 91421-42-0
Camptothecin Experimental Phase 2 7689-03-4
Lonafarnib Investigational Phase 2 193275-84-2 148195
37 Piritrexim Investigational Phase 2 72732-56-0
38 Guadecitabine Investigational Phase 2 929901-49-5
39 Alkylating Agents Phase 2
Isophosphamide mustard Phase 2 0
41 Angiogenesis Inhibitors Phase 2
42 Fluorodeoxyglucose F18 Phase 2
43 Radiopharmaceuticals Phase 2
44 topoisomerase I inhibitors Phase 2
45 Antifungal Agents Phase 1, Phase 2
46 Epothilone B Phase 2
47 Epothilones Phase 2
48 Lactams Phase 2
49 Protein Kinase Inhibitors Phase 2
50 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Phase III Trial of Methotrexate, Vinblastine, Doxorubicin and Cisplatin vs Carboplatin and Paclitaxel in Advanced Carcinoma of the Urothelium Completed NCT00003376 Phase 3 carboplatin;cisplatin;doxorubicin hydrochloride;methotrexate;paclitaxel;vinblastine
2 Randomized Phase II/III Study Assessing Gemcitabine/Carboplatin And Methotrexate/Carboplatin/Vinblastine In Previously Untreated Patients With Advanced Urothelial Cancer Ineligible For Cisplatin Based Chemotherapy Completed NCT00014274 Phase 2, Phase 3 carboplatin;gemcitabine hydrochloride;methotrexate;vinblastine sulfate
3 A Phase III Randomized Trial of Either M-VAC or Paclitaxel + Carboplatin as Postoperative Adjuvant Therapy in Patients With Muscle-Invasive Transitional Cell Carcinoma of the Bladder at High-Risk for Relapse Completed NCT00003701 Phase 3 carboplatin;cisplatin;doxorubicin hydrochloride;methotrexate;paclitaxel;vinblastine sulfate
4 Randomized Phase III Study Comparing Paclitaxel/Cisplatin/Gemcitabine and Cisplatin/Gemcitabine in Patients With Metastatic or Locally Advanced Urothelial Cancer Without Prior Systemic Therapy Completed NCT00022191 Phase 3 cisplatin;gemcitabine hydrochloride;paclitaxel
5 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
6 A Phase II Study Assessing SU-011248 in Previously Untreated Patients With Advanced Urothelial Cancer Ineligible for Cisplatin-Based Chemotherapy Unknown status NCT01118039 Phase 2 sunitinib malate
7 Multicenter Study of the Quality of Life of Patients With Invasive Urothelial Cancer Treated With Conservative Surgery Followed by Cisplatin, Fluorouracil and Radiotherapy Unknown status NCT00006111 Phase 2 cisplatin;fluorouracil
8 Phase II Trial of Paclitaxel, Cisplatin and Ifosfamide in Patients With Advanced Urothelial Tumors Completed NCT00002684 Phase 2 cisplatin;ifosfamide;paclitaxel
9 Phase II Study of Sunitinib in Metastatic Transitional Cell Carcinoma of the Urothelium Completed NCT00397488 Phase 2 sunitinib malate
10 Phase 2 Study With the Multi-Targeted Tyrosine-Kinase Inhibitor Pazopanib (GW786034) for Patients With Relapsed or Refractory Urothelial Cancer Completed NCT01031875 Phase 2 pazopanib hydrochloride
11 Open Label Phase II Study on RFS 2000 (9-Nitro-Camptothecin, 9-NC) Administered as a "5 Days On-2 Days Off" Oral Treatment in Advanced/Metastatic Urothelial Tract Tumors Completed NCT00006026 Phase 2 rubitecan
12 Phase II Trial of Paclitaxel Plus Gemcitabine in Patients With Advanced Urothelial Carcinoma With Renal Insufficiency Completed NCT00005644 Phase 2 gemcitabine hydrochloride;paclitaxel
13 Evaluation of ZD1839 (NSC #715055) for Advanced Transitional Cell Carcinoma of the Urothelium, Phase II Completed NCT00014144 Phase 2 gefitinib
14 Phase II Study on SCH 66336 (Farnesyl Protein Transferase Inhibitor) and Gemcitabine as Second Line Treatment in Advanced Metastatic Urothelial Cancer - EORTC Study 16997 Completed NCT00006351 Phase 2 gemcitabine hydrochloride;lonafarnib
15 Phase II Study of Irinotecan in Patients With Advanced Transitional Cell Carcinoma of the Urothelium Completed NCT00066612 Phase 2 irinotecan hydrochloride
16 Phase II Trial Of Pemetrexed Disodium And Gemcitabine In Advanced Urothelial Cancer Completed NCT00053209 Phase 2 gemcitabine hydrochloride;pemetrexed disodium
17 Phase II Trial of Neoadjuvant, Multi-Agent Chemotherapy For Locally Advanced Urothelial Cancer Completed NCT00080795 Phase 2 cisplatin;doxorubicin hydrochloride;gemcitabine hydrochloride;ifosfamide
18 A Phase II Single-Arm Trial to Evaluate Cisplatin and Gemcitabine Chemotherapy in Combination With Sunitinib for First-Line Treatment of Patients With Advanced Transitional Carcinoma of the Urothelium Completed NCT01089088 Phase 2 cisplatin;gemcitabine hydrochloride;sunitinib malate
19 A Phase I/II Single-Arm Trial to Evaluate the Combination of Cisplatin and Gemcitabine With the mTOR Inhibitor Temsirolimus for First-Line Treatment of Patients With Advanced Transitional Cell Carcinoma of the Urothelium Completed NCT01090466 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;temsirolimus
20 A Sequential Approach to the Treatment of Muscle Invasive, Non-Metastatic Urothelial Carcinoma of the Bladder: A Phase II Trial of Neoadjuvant Gemcitabine, Paclitaxel and Carboplatin With Molecular Correlates Completed NCT00045630 Phase 2 carboplatin;gemcitabine;paclitaxel
21 Phase II Evaluation of Carboplatin, Paclitaxel and Gemcitabine Followed by Concurrent Cisplatin and Radiation Therapy in Patients With Locally Advanced or Recurrent Urothelial Malignancy Completed NCT00055835 Phase 2 carboplatin;cisplatin;gemcitabine hydrochloride;paclitaxel
22 A Randomized Phase II Trial of Carboplatin and Gemcitabine +/- Vandetanib in First Line Treatment of Advanced Urothelial Cell Cancer in Patients Who Are Not Suitable to Receive Cisplatin Completed NCT01191892 Phase 2 carboplatin;gemcitabine hydrochloride;vandetanib;Placebo
23 A Phase II Safety and Efficacy Study With the VEGF Receptor Tyrosine Kinase Inhibitor GW786034 in Patients With Metastatic Urothelial Cancer Completed NCT00471536 Phase 2 pazopanib hydrochloride
25 A Phase II Study of Continuous 5-Fluorouracil (5-FU) in Recurrent Locally Advanced or Metastatic Transitional Cell Carcinoma of the Urinary Tract Completed NCT00003175 Phase 2 fluorouracil
26 A Phase II Study Of Epothilone B Analogue BMS-247550 (NSC #710428) q21 Days In Advanced Carcinoma Of The Urothelium Completed NCT00021099 Phase 2 ixabepilone
27 Phase II Trial of Gemcitabine and Docetaxel in Advanced Carcinoma of the Urothelium Completed NCT00004223 Phase 2 docetaxel;gemcitabine hydrochloride
28 A Phase II Study of Gemcitabine, Paclitaxel, and Doxorubicin, With Pegfilgrastim for the Treatment of Patients With Metastatic Transitional Cell Carcinoma and Renal Insufficiency Completed NCT00478361 Phase 2 Gemcitabine hydrochloride;Paclitaxel;Doxorubicin hydrochloride;Pegfilgrastim
29 GU-114: Overcoming Checkpoint Inhibitor Resistance With Epigenetic Therapy in Urothelial Cancer Recruiting NCT03179943 Phase 2 Atezolizumab;Guadecitabine
30 Afatinib Dimaleate in Treating Patients With Advanced Refractory Urothelial Cancer Recruiting NCT02122172 Phase 2 afatinib dimaleate
31 Phase II Trial of 5-FU, Leucovorin, Gemcitabine, and Cisplatin for Adenocarcinomas of the Urothelial Tract and Urachal Remnant Active, not recruiting NCT00082706 Phase 2 5-Fluorouracil (5-FU);Leucovorin;Cisplatin;Gemcitabine
32 A Phase II Study of Depsipeptide (NSC-630176) In Patients With Advanced Transitional Cell Carcinoma Of The Urinary Tract Who Have Progressed After Receiving One Prior Chemotherapy Regimen For Advanced Disease Terminated NCT00087295 Phase 2 Depsipeptide
33 Protocol for Assessment of Gemcitabine and Paclitaxel for Metastatic Urothelial Cancer in Patients Aged 70 Years or Older (and in a Cohort of Patients Younger Than 60 Years) Terminated NCT00022633 Phase 2 gemcitabine hydrochloride;paclitaxel
34 A Phase II Trial of Trastuzumab (Herceptin; NSC #688097, IND #6667) in Patients With Previously Treated Advanced Urothelial Tract Transitional Cell Carcinoma Terminated NCT00004856 Phase 2
35 Phase II Trial of Neoadjuvant Dose Dense Gemcitabine and Cisplatin In Muscle Invasive Bladder Cancer Terminated NCT01611662 Phase 2 gemcitabine hydrochloride;cisplatin
36 A Randomized, Phase 2, Open-label Study Evaluating DN24-02 as Adjuvant Therapy in Subjects With High Risk HER2+ Urothelial Carcinoma Terminated NCT01353222 Phase 2
37 Randomized Phase II Trial Of Adjuvant Chemotherapy For Urothelial Carcinoma Comparing GC To Dose-Dense MVAC Withdrawn NCT01639521 Phase 2 cisplatin;gemcitabine hydrochloride;methotrexate;vinblastine;doxorubicin hydrochloride
38 A Phase I Clinical Trial of Intrapleural Adenoviral-Mediated Interferon-beta (IFN-ß) Gene Transfer for Pleural Malignancies Unknown status NCT00066404 Phase 1
39 Modulation of Death Effector Expression By Short-Term Exposure to Low-Dose Interferon Completed NCT00082719 Phase 1
40 Phase I Study of Oral Capecitabine (Xeloda) as a Radiation Enhancer in Locally Unresectable, Residual, or Recurrent Colorectal Cancer Localized in the Pelvis Completed NCT00003704 Phase 1 capecitabine
41 An Open Label, Sequential Cohort Dose-Escalation Safety, Tolerability and Pharmacokinetic Study of VEGF Trap Administered Intravenously in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00083213 Phase 1
42 An Open-Label, Long-Term, Safety and Tolerability Study of VEGF Trap Administered Intravenously in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00082823 Phase 1
43 A Phase I, Pharmacokinetic, and Biologic Correlative Study of R115777 (NSC 702818) and Herceptin in Patients With Advanced Cancer Completed NCT00005842 Phase 1 tipifarnib
44 Phase I Pharmacokinetic Trial of Thalidomide and Docetaxel: A Regimen Based on Anti-Angiogenic Therapeutic Principles Completed NCT00049296 Phase 1 docetaxel;thalidomide
45 A Phase I Study of an Oral Histone Deacetylase Inhibitor, MS-275, in Refractory Solid Tumors and Lymphomas Completed NCT00020579 Phase 1 entinostat
46 A Phase I Study of Gemcitabine, Carboplatin and Lenalidomide (GCL) for Treatment of Patients With Advanced/Metastatic Urothelial Carcinoma (UC) and Other Solid Tumors Completed NCT01352962 Phase 1 Gemcitabine;Carboplatin;Lenalidomide
47 Phase I Two-Dimensional Dose-Finding Study of Bortezomib in Combination With Gemcitabine/Doxorubicin in Metastatic Surgically Unresectable Urothelial Cancer or Other Solid Tumors Active, not recruiting NCT00479128 Phase 1 Bortezomib;Gemcitabine;Doxorubicin
48 BARC: A Secreted Marker of Kidney Cancer Completed NCT00900276
49 Improving Palliative Care for Patients With Cancer Completed NCT00253383
50 Videoscopic Versus Open Inguinal Lymphadenectomy for Sentinel Node Positive Cutaneous Malignancies and Genitourinary Staging Procedures Completed NCT01526486

Search NIH Clinical Center for Urethral Cancer

Genetic Tests for Urethral Cancer

Anatomical Context for Urethral Cancer

MalaCards organs/tissues related to Urethral Cancer:

Prostate, Kidney, Liver, Lymph Node, Bone, Colon, Lung

Publications for Urethral Cancer

Articles related to Urethral Cancer:

(show top 50) (show all 334)
# Title Authors PMID Year
Organ-sparing procedures in GU cancer: part 3-organ-sparing procedures in urothelial cancer of upper tract, bladder and urethra. 61
31352580 2019
MRI of the penis. 61
31701192 2019
Primary urethral carcinoma - unexpected cause of urethral stricture. Case report and review of the literature. 61
31765461 2019
Advanced primary urethral cancer: a case report. 61
31779706 2019
Nomograms for predicting long-term overall survival and cancer-specific survival in patients with primary urethral carcinoma: a population-based study. 61
31612421 2019
Current Disease Management of Primary Urethral Carcinoma. 61
31307949 2019
Primary adenocarcinoma of bulbomembranous urethra: An exceedingly rare carcinoma in a male patient. 61
31297328 2019
[A Case of Urethral Carcinoma in Situ Resected by Urethrectomy of Anterior Urethra]. 61
31501403 2019
Metastatic primary urothelial carcinoma of the prostatic urethra: A case report. 61
30373476 2019
Pathologic Complete Response After Chemoradiation of a Massive Primary Urethral Carcinoma. 61
31360804 2019
A Case of Metastatic Prostate Cancer to the Urethra That Resolved After Androgen Deprivation Therapy. 61
30935936 2019
Robotic-assisted Intraoperative High-dose Rate Remote Brachytherapy Following Laparoscopic Robotic-assisted Resection of Pelvic Recurrence of Urethral Carcinoma. 61
31360797 2019
Urothelial carcinoma of the bladder, lipid cell variant: A case report and literature review. 61
31308313 2019
Primary Urethral Carcinoma With Nodal Metastasis. 61
30867633 2019
Primary urothelial carcinoma of the prostate: A rare case report. 61
30653154 2019
The role of inguinal lymph node dissection in men with urethral squamous cell carcinoma. 61
30446445 2018
Optimizing the Role of Surgery and Radiation Therapy in Urethral Cancer Based on Histology and Disease Extent. 61
29908944 2018
Survival Outcomes Associated With Female Primary Urethral Carcinoma: Review of a Single Institutional Experience. 61
29859736 2018
Treatment and Outcomes of Primary Urethra Cancer. 61
28537991 2018
Skin flap squamous cell carcinoma developed after urethroplasty. 61
29974731 2018
Muscle-invasive bladder and urethral cancer recurrence after surgical management of upper tract urothelial carcinoma: A review of 305 patients. 61
29733795 2018
Novel Treatment Setup for Urethral Cancer: Use of the Prone Technique for Radiotherapy of the Penis. 61
29867434 2018
IMP1 regulates UCA1-mediated cell invasion through facilitating UCA1 decay and decreasing the sponge effect of UCA1 for miR-122-5p. 61
29669595 2018
Primary urethral carcinoma: A Surveillance, Epidemiology, and End Results data analysis identifying predictors of cancer-specific survival. 61
29719329 2018
Skene duct adenocarcinoma in a patient with an elevated serum prostate-specific antigen level: a case report. 61
29439715 2018
Prognosis of rare pathological primary urethral carcinoma. 61
30584373 2018
The prognostic effect of salvage surgery and radiotherapy in patients with recurrent primary urethral carcinoma. 61
29055518 2018
Clear cell adenocarcinoma of the urethra with inguinal lymph node metastases: A rare case report and review of literature. 61
29516944 2018
A rare case of primary female urethral adenocarcinoma: Columnar type with colonic adenocarcinoma features. 61
29567902 2018
Secondary Urethral Malignancies Following Prostate Brachytherapy. 61
28882777 2017
Contemporary practice patterns and survival outcomes for locally advanced urethral malignancies: A National Cancer Database Analysis. 61
28803701 2017
Magnetic Resonance Imaging of a Urethral Caruncle and the Pathologic Correlation: A Report of 3 Cases. 61
29135706 2017
Skene's gland adenocarcinoma with intestinal differentiation: A case report and literature review. 61
28872768 2017
Primary Adenocarcinoma of the Bulbomembranous Urethra in a 33-Year-Old Male Patient. 61
29207776 2017
Venous Thromboembolism Risk in Patients With Locoregional Urothelial Tract Tumors. 61
28923700 2017
Augmented perineal urethrostomy using a dorsal buccal mucosal graft, bi-institutional study. 61
28108798 2017
Priapism with penile gangrene: An unusual presentation of multiple myeloma. 61
28717280 2017
Impact of the Level of Urothelial Carcinoma Involvement of the Prostate on Survival after Radical Cystectomy. 61
28824943 2017
Unusual asymptomatic presentation of bladder cancer metastatic to the penis. 61
28476381 2017
Association of Smoking, Alcohol Use, and Betel Quid Chewing with Epigenetic Aberrations in Cancers. 61
28587272 2017
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Caused by Carboplatin After Switching from Cisplatin in a Metastatic Urethral Cancer Patient. 61
28271051 2017
Urethral carcinoma in situ: recognition and management. 61
28101735 2017
Outcomes and Prognostic Factors of Primary Urethral Cancer. 61
27720774 2017
Sex-related differences in clinicopathological features and survival of patients with primary urethral carcinoma: a population-based study. 61
28744142 2017
[Urethral ectropion may hide a carcinoma!] 61
28979650 2017
Advances in Surgical Reconstructive Techniques in the Management of Penile, Urethral, and Scrotal Cancer. 61
27717440 2016
Contemporary Management of Primary Distal Urethral Cancer. 61
27717435 2016
Robot-Assisted Simultaneous Bilateral Radical Inguinal Lymphadenectomy Along with Robotic Bilateral Pelvic Lymphadenectomy: A Feasibility Study. 61
27243665 2016
Management of Urethral Recurrences: Urothelial and Nonurothelial. 61
27717437 2016
Management of Proximal Primary Urethral Cancer: Should Multidisciplinary Therapy Be the Gold Standard? 61
27717436 2016

Variations for Urethral Cancer

Expression for Urethral Cancer

Search GEO for disease gene expression data for Urethral Cancer.

Pathways for Urethral Cancer

GO Terms for Urethral Cancer

Sources for Urethral Cancer

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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